A 70-year-old gentleman underwent prostatectomy for bladder outlet obstruction due to enlarged prostate and was found to have primary extragastrointestinal stromal tumour (EGIST). He has been started on imatinib therapy and is presently on follow-up. Prostatic EGIST should be one of the differential diagnoses in patients with enlarged prostate with normal prostate-specific antigen levels.Key words: Prostate, gastrointestinal stromal tumour, PSA
{"title":"PRIMARY GASTROINTESTINAL STROMAL TUMOUR OF THE PROSTATE: A CASE REPORT OF A RARE TUMOUR","authors":"M. A. I. Khalil, N. Khan, Azfar Ali, K. Mir","doi":"10.37029/jcas.v4i2.161","DOIUrl":"https://doi.org/10.37029/jcas.v4i2.161","url":null,"abstract":"A 70-year-old gentleman underwent prostatectomy for bladder outlet obstruction due to enlarged prostate and was found to have primary extragastrointestinal stromal tumour (EGIST). He has been started on imatinib therapy and is presently on follow-up. Prostatic EGIST should be one of the differential diagnoses in patients with enlarged prostate with normal prostate-specific antigen levels.Key words: Prostate, gastrointestinal stromal tumour, PSA ","PeriodicalId":73631,"journal":{"name":"Journal of cancer & allied specialties","volume":"5 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80252971","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
N. Muhammad, Ramsha Nawaz, F. Khan, H. Naeemi, M. U. Rashid
Breast cancer is a heterogeneous disease. Several genetic, environmental and lifestyle factors are involved in the aetiology of this disease. Genetic risk factors include alterations (mutations) in genes conferring risks to develop breast cancer. Depending on the associated lifetime risks of this malignancy, these genes are categorised into high-, moderate- and low-risk genes. Women carrying mutations in these genes are at an increased risk to develop breast cancer, ovarian cancer and several other malignancies. Breast carcinoma is the most reported malignancy in Pakistani females. Pakistan is a developing country with most of its population living in rural areas; hence, optimal healthcare facilities are inadequate for the early diagnosis and prevention of this disease. Hence, identification of individuals carrying mutations is clinically relevant as different strategies are available for the early detection, risk reduction and better management of this malignancy. This review summarises the findings of the major studies conducted in Pakistan to investigate the contribution of breast cancer predisposing genes. Furthermore, implications of the current studies and future research potentials are discussed.Key words: Breast cancer gene 1/2, breast cancer, checkpoint kinase 2, genetic susceptibility, Pakistan, RAD51C, tumour Protein p53, Vitamin D receptor
{"title":"INHERITED GENETIC SUSCEPTIBILITY TO BREAST CANCER IN PAKISTAN","authors":"N. Muhammad, Ramsha Nawaz, F. Khan, H. Naeemi, M. U. Rashid","doi":"10.37029/JCAS.V4I2.179","DOIUrl":"https://doi.org/10.37029/JCAS.V4I2.179","url":null,"abstract":"Breast cancer is a heterogeneous disease. Several genetic, environmental and lifestyle factors are involved in the aetiology of this disease. Genetic risk factors include alterations (mutations) in genes conferring risks to develop breast cancer. Depending on the associated lifetime risks of this malignancy, these genes are categorised into high-, moderate- and low-risk genes. Women carrying mutations in these genes are at an increased risk to develop breast cancer, ovarian cancer and several other malignancies. Breast carcinoma is the most reported malignancy in Pakistani females. Pakistan is a developing country with most of its population living in rural areas; hence, optimal healthcare facilities are inadequate for the early diagnosis and prevention of this disease. Hence, identification of individuals carrying mutations is clinically relevant as different strategies are available for the early detection, risk reduction and better management of this malignancy. This review summarises the findings of the major studies conducted in Pakistan to investigate the contribution of breast cancer predisposing genes. Furthermore, implications of the current studies and future research potentials are discussed.Key words: Breast cancer gene 1/2, breast cancer, checkpoint kinase 2, genetic susceptibility, Pakistan, RAD51C, tumour Protein p53, Vitamin D receptor","PeriodicalId":73631,"journal":{"name":"Journal of cancer & allied specialties","volume":"85 4 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76195440","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"THERANOSTICS- NEUROENDOCRINE TUMOURS","authors":"M. Younis, H. Bashir","doi":"10.37029/JCAS.V4I2.184","DOIUrl":"https://doi.org/10.37029/JCAS.V4I2.184","url":null,"abstract":"<jats:p>-</jats:p>","PeriodicalId":73631,"journal":{"name":"Journal of cancer & allied specialties","volume":"89 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88123016","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"AIR BRONCHOGRAM: THE UNTRUSTWORTHY SIGN","authors":"Qurat-ul-Ain Shah, U. Masood, I. Niazi","doi":"10.37029/JCAS.V4I2.180","DOIUrl":"https://doi.org/10.37029/JCAS.V4I2.180","url":null,"abstract":"<jats:p>-</jats:p>","PeriodicalId":73631,"journal":{"name":"Journal of cancer & allied specialties","volume":"12 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74319387","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Background: The practice of spinal and epidural anaesthesia is well established the world over for a number of years. Sighting of spinal or epidural is conducted through various approaches at various levels of the spinal column. The number of attempts has its correlation with the post-spinal and epidural complications.Aim: The aim is to gather information about the understanding among the anaesthetists about the spinal/epidural attempt.Materials and Methods: A pro forma comprising of nine closed-loop questions was distributed to all the participants in the study, and they were requested to fill it anonymously and placed it back in a designated sealed box in anaesthetic office.Results: A total of 20 pro formas were distributed, and all of them received back with 100% responses. All the participants accepted universally that attempting through another space makes it a second attempt. One of the respondents thought any backward movement means 2nd attempt, the majority of the responders thought it does not count as an attempt. Almost everyone considered another attempt if a needle is completely withdrawn and enters through another puncture site whether through a midline or paramedian approach.Conclusion: Most of the complications after neuraxial blockade are associated with the number of attempts alongside other factors that may play a role. A universal definition of a spinal and epidural attempt may decrease the complications associated with the central neuraxial blockade.Key words: Epidural, single attempt, spinal
{"title":"WHAT IS YOUR UNDERSTANDING OF SPINAL AND EPIDURAL ATTEMPT?","authors":"S. Yahya, A. Siddiqui","doi":"10.37029/JCAS.V4I2.165","DOIUrl":"https://doi.org/10.37029/JCAS.V4I2.165","url":null,"abstract":"Background: The practice of spinal and epidural anaesthesia is well established the world over for a number of years. Sighting of spinal or epidural is conducted through various approaches at various levels of the spinal column. The number of attempts has its correlation with the post-spinal and epidural complications.Aim: The aim is to gather information about the understanding among the anaesthetists about the spinal/epidural attempt.Materials and Methods: A pro forma comprising of nine closed-loop questions was distributed to all the participants in the study, and they were requested to fill it anonymously and placed it back in a designated sealed box in anaesthetic office.Results: A total of 20 pro formas were distributed, and all of them received back with 100% responses. All the participants accepted universally that attempting through another space makes it a second attempt. One of the respondents thought any backward movement means 2nd attempt, the majority of the responders thought it does not count as an attempt. Almost everyone considered another attempt if a needle is completely withdrawn and enters through another puncture site whether through a midline or paramedian approach.Conclusion: Most of the complications after neuraxial blockade are associated with the number of attempts alongside other factors that may play a role. A universal definition of a spinal and epidural attempt may decrease the complications associated with the central neuraxial blockade.Key words: Epidural, single attempt, spinal","PeriodicalId":73631,"journal":{"name":"Journal of cancer & allied specialties","volume":"22 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84489298","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
N. Khan, M. A. I. Khalil, Azfar Ali, A. Naeem, A. Rehman, K. Mir
Background: A high number of clinical T1 (cT1) stage renal cell carcinoma (RCC) is upstaged to pathological T3a (pT3a) stage on histopathological findings. Several study results show that there is no survival difference among those cT1 stage who are upstaged on histopathological findings to those who remain pT1 stage RCC.Objectives: The objectives of this study were to assess any survival difference for cT1 stage renal cell carcinoma (RCC) which is upstaged to pT3a stage as compared to those which remain pT1 stage RCC on histopathological findings.Materials and Methods: It was a retrospective cohort study looking at patient aged ≥18 years with cT1 RCC who underwent nephrectomy between January 2006 and December 2016. Patients were divided into two groups based on histopathological findings (pT1 vs. pT3a). Survival was analysed for the two groups using Kaplan–Meier method, and the difference in survival was calculated using log-rank model.Results: The study included 187 patients. The mean age at presentation was 52.56 years, with 58.3% of the patients being male while 41.7% were female. The most common presentation was incidental diagnosis (50.3%). Overall5-year survival for cT1a and pT1a RCC was 68% while that for cT1a and pT3a RCC was 100%. There was no significant survival difference among the two groups (P = 0.316). The overall 5-year survival for cT1b and pT1b RCC was 81% while that for cT1b and pT3a was 65%. There was no significant survival difference among the two groups (P = 0.136).Conclusion: We found no survival difference in cT1 RCC who were upstaged to pT3a on histopathology as compared to cT1 RCC-staged pT1 on histopathology.Key words: Clinical T1 stage, pathological T3a stage, radical nephrectomy, renal cell carcinoma, survival
{"title":"DOES PATHOLOGICAL T3A UPSTAGING OF CLINICAL T1 STAGE HAS ANY DIFFERENCE ON LONG-TERM SURVIVAL WHEN COMPARED TO PATHOLOGICAL AND CLINICAL T1 STAGE RENAL CELL CARCINOMA","authors":"N. Khan, M. A. I. Khalil, Azfar Ali, A. Naeem, A. Rehman, K. Mir","doi":"10.37029/jcas.v4i2.164","DOIUrl":"https://doi.org/10.37029/jcas.v4i2.164","url":null,"abstract":"Background: A high number of clinical T1 (cT1) stage renal cell carcinoma (RCC) is upstaged to pathological T3a (pT3a) stage on histopathological findings. Several study results show that there is no survival difference among those cT1 stage who are upstaged on histopathological findings to those who remain pT1 stage RCC.Objectives: The objectives of this study were to assess any survival difference for cT1 stage renal cell carcinoma (RCC) which is upstaged to pT3a stage as compared to those which remain pT1 stage RCC on histopathological findings.Materials and Methods: It was a retrospective cohort study looking at patient aged ≥18 years with cT1 RCC who underwent nephrectomy between January 2006 and December 2016. Patients were divided into two groups based on histopathological findings (pT1 vs. pT3a). Survival was analysed for the two groups using Kaplan–Meier method, and the difference in survival was calculated using log-rank model.Results: The study included 187 patients. The mean age at presentation was 52.56 years, with 58.3% of the patients being male while 41.7% were female. The most common presentation was incidental diagnosis (50.3%). Overall5-year survival for cT1a and pT1a RCC was 68% while that for cT1a and pT3a RCC was 100%. There was no significant survival difference among the two groups (P = 0.316). The overall 5-year survival for cT1b and pT1b RCC was 81% while that for cT1b and pT3a was 65%. There was no significant survival difference among the two groups (P = 0.136).Conclusion: We found no survival difference in cT1 RCC who were upstaged to pT3a on histopathology as compared to cT1 RCC-staged pT1 on histopathology.Key words: Clinical T1 stage, pathological T3a stage, radical nephrectomy, renal cell carcinoma, survival","PeriodicalId":73631,"journal":{"name":"Journal of cancer & allied specialties","volume":"58 6","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72453203","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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