Pub Date : 2019-10-31DOI: 10.23937/2572-3286.1510048
Menye Hermine Danielle Fouda, W. Gilles, F KazeFrancois, G TeuwafeuDenis, Kane Yaya, Halle Marie Patrice, M. Maimouna, Djantio Hilaire, A. Gloria
Background: Studies in Cameroon reported high prevalence of urinary abnormalities in sickle cell anemia (SCA). There is a lack of data in this setting on the prevalence of chronic kidney disease (CKD) in SCA and Sickle cell trait (SCT). Objective: Assess the prevalence and associate factors of CKD in people with sickle cell disease. Patients and method: This was a cross-sectional study of six months durations (April-September 2017) involving SCA (HB SS) and SCT (HBAS) subjects at Douala Laquintinie hospital. CKD was diagnosed and classified according to 2012 Kidney Disease Improving Global Outcomes (KDIGO) criteria. Only patients with persistent urinary anomalies or decreased eGFR at 3 months were considered to have CKD. Results: We included 107 subjects among which 81 SCA (62% males) and 26 SCT (46% males) with a mean age of 19.5 ± 10 and 35.8 ± 7.8 years (p < 0.001) respectively. Compare to SCT, SCA subjects had lower body mass index and systolic blood pressure. Overall, CKD was found in 16 patients (15%): 13 (16%) patients in the SCA group and 3 patients (11%) in the SCT group. CKD frequency was comparable in both groups (p = 0.76). CKD was found in 37% of adult SCA patients. Albuminuria was more common in the SCA group [12 (15%) vs. 1 (4%) patient, p = 0.018]. Age ≤ 25 years was protective factor for both CKD (OR = 0.20 [0.003-0.135], p < 0.001) and albuminuria (OR = 0.23 [0.004-0.124], p < 0.001) in SCD group. Conclusion: CKD in sickle cell disease is highly prevalent young adult in our setting.
{"title":"Chronic Kidney Disease in Sickle Cell Disease: Prevalence and Associated Factors in Cameroon","authors":"Menye Hermine Danielle Fouda, W. Gilles, F KazeFrancois, G TeuwafeuDenis, Kane Yaya, Halle Marie Patrice, M. Maimouna, Djantio Hilaire, A. Gloria","doi":"10.23937/2572-3286.1510048","DOIUrl":"https://doi.org/10.23937/2572-3286.1510048","url":null,"abstract":"Background: Studies in Cameroon reported high prevalence of urinary abnormalities in sickle cell anemia (SCA). There is a lack of data in this setting on the prevalence of chronic kidney disease (CKD) in SCA and Sickle cell trait (SCT). Objective: Assess the prevalence and associate factors of CKD in people with sickle cell disease. Patients and method: This was a cross-sectional study of six months durations (April-September 2017) involving SCA (HB SS) and SCT (HBAS) subjects at Douala Laquintinie hospital. CKD was diagnosed and classified according to 2012 Kidney Disease Improving Global Outcomes (KDIGO) criteria. Only patients with persistent urinary anomalies or decreased eGFR at 3 months were considered to have CKD. Results: We included 107 subjects among which 81 SCA (62% males) and 26 SCT (46% males) with a mean age of 19.5 ± 10 and 35.8 ± 7.8 years (p < 0.001) respectively. Compare to SCT, SCA subjects had lower body mass index and systolic blood pressure. Overall, CKD was found in 16 patients (15%): 13 (16%) patients in the SCA group and 3 patients (11%) in the SCT group. CKD frequency was comparable in both groups (p = 0.76). CKD was found in 37% of adult SCA patients. Albuminuria was more common in the SCA group [12 (15%) vs. 1 (4%) patient, p = 0.018]. Age ≤ 25 years was protective factor for both CKD (OR = 0.20 [0.003-0.135], p < 0.001) and albuminuria (OR = 0.23 [0.004-0.124], p < 0.001) in SCD group. Conclusion: CKD in sickle cell disease is highly prevalent young adult in our setting.","PeriodicalId":73669,"journal":{"name":"Journal of clinical nephrology and renal care","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-10-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47188591","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-09-27DOI: 10.23937/2572-3286.1510047
Kennedy Amy D, Liu Alex J, Seipp Regan M, Ryan Margaret S, Yang Shaun K, Thomas Leslie F
This case report examines two rare mechanisms of acute renal failure in a patient with metastatic melanoma treated with high-dose vitamin C. The first is oxalate nephropathy, which is an uncommon but known complication of highdose vitamin C therapy in naturopathic medicine. The second is due to melanuria and renal melanosis, which has been described in metastatic melanoma; however, acute renal failure requiring renal replacement therapy has not been reported previously.
{"title":"Two Rare Mechanisms for Acute Anuric Renal Failure in a Patient with Metastatic Malignant Melanoma - A Case Report","authors":"Kennedy Amy D, Liu Alex J, Seipp Regan M, Ryan Margaret S, Yang Shaun K, Thomas Leslie F","doi":"10.23937/2572-3286.1510047","DOIUrl":"https://doi.org/10.23937/2572-3286.1510047","url":null,"abstract":"This case report examines two rare mechanisms of acute renal failure in a patient with metastatic melanoma treated with high-dose vitamin C. The first is oxalate nephropathy, which is an uncommon but known complication of highdose vitamin C therapy in naturopathic medicine. The second is due to melanuria and renal melanosis, which has been described in metastatic melanoma; however, acute renal failure requiring renal replacement therapy has not been reported previously.","PeriodicalId":73669,"journal":{"name":"Journal of clinical nephrology and renal care","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44900647","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-09-25DOI: 10.23937/2572-3286.1510046
Dias Joana Monteiro, Alves Rita Valério, G. Mário, Viana Helena, N. Fernando
Background: Diabetic nephropathy (DN) has been historically the major cause of kidney disease in diabetic patients. However, recent studies have found a high proportion of diabetic patients with biopsy proven Non-diabetic renal disease (NDRD) or NDRD superimposed on DN. These findings have resurfaced the interest in establishing which of these patients may benefit most from a kidney biopsy. Our study aims to enlighten the prevalence and etiology of biopsy proven NDRD and to explore clinical and morphologic differences encountered in the diabetic patient with NDRD. Methods: Medical records of all diabetic patients who underwent native kidney biopsy for suspected NDRD from January 2016 to December 2018 at Hospital Curry Cabral Centro Hospitalar Universitário de Lisboa Central, EPE, were analysed retrospectively. Results: We review medical records of 67 patients. All patients had a diabetes mellitus diagnosis at the time of biopsy and were biopsied for NDRD suspicion. In our population, 55.2% had DN (7.5% presented simultaneously DN and NDRD) and 41.8% had isolated NDRD. The most frequent causes of NDRD were IgA nephropathy (25%) and Chronic Interstitial Nephritis (10.8%). A shorter duration of diabetes had a statistically significant association with NDRD. Conclusions: Nearly half diabetic patients proposed to kidney biopsy have a NDRD. Since kidney biopsy is essential to establish the diagnosis and subsequently provide adequate treatment, this resource should be used in the diabetic diabetic patient with NDRD suspicion, especially in those with a shorter duration of diabetes. Additional data is necessary to establish which patients should be proposed to earlier kidney biopsies.
背景:糖尿病肾病(DN)历来是糖尿病患者肾脏疾病的主要原因。然而，最近的研究发现，高比例的糖尿病患者活检证实非糖尿病性肾病(NDRD)或NDRD叠加在DN。这些发现重新引起了人们的兴趣，即确定哪些患者可能从肾活检中获益最多。我们的研究旨在揭示活检证实的NDRD的患病率和病因，并探讨糖尿病合并NDRD患者的临床和形态学差异。方法:回顾性分析2016年1月至2018年12月在里斯本中心医院(Universitário de Lisboa Central Hospital Curry Cabral Centro Hospital)接受疑似NDRD肾活检的所有糖尿病患者的病历。结果:我们回顾了67例患者的病历。所有患者在活检时都诊断为糖尿病，并对NDRD进行了活检。在我们的人群中，55.2%的人患有DN(7.5%的人同时患有DN和NDRD)， 41.8%的人患有孤立性NDRD。NDRD最常见的病因是IgA肾病(25%)和慢性间质性肾炎(10.8%)。较短的糖尿病病程与NDRD有统计学上显著的关联。结论:近一半接受肾活检的糖尿病患者存在NDRD。由于肾脏活检对于确定诊断并随后提供适当的治疗至关重要，因此该方法应用于怀疑患有NDRD的糖尿病患者，特别是那些糖尿病病程较短的糖尿病患者。需要额外的数据来确定哪些患者应该建议进行早期肾活检。
{"title":"Prevalence, Etiology and Clinical Characteristics of Biopsy Proven Non-Diabetic Renal Disease in a Population of 67 Diabetic Patients","authors":"Dias Joana Monteiro, Alves Rita Valério, G. Mário, Viana Helena, N. Fernando","doi":"10.23937/2572-3286.1510046","DOIUrl":"https://doi.org/10.23937/2572-3286.1510046","url":null,"abstract":"Background: Diabetic nephropathy (DN) has been historically the major cause of kidney disease in diabetic patients. However, recent studies have found a high proportion of diabetic patients with biopsy proven Non-diabetic renal disease (NDRD) or NDRD superimposed on DN. These findings have resurfaced the interest in establishing which of these patients may benefit most from a kidney biopsy. Our study aims to enlighten the prevalence and etiology of biopsy proven NDRD and to explore clinical and morphologic differences encountered in the diabetic patient with NDRD. Methods: Medical records of all diabetic patients who underwent native kidney biopsy for suspected NDRD from January 2016 to December 2018 at Hospital Curry Cabral Centro Hospitalar Universitário de Lisboa Central, EPE, were analysed retrospectively. Results: We review medical records of 67 patients. All patients had a diabetes mellitus diagnosis at the time of biopsy and were biopsied for NDRD suspicion. In our population, 55.2% had DN (7.5% presented simultaneously DN and NDRD) and 41.8% had isolated NDRD. The most frequent causes of NDRD were IgA nephropathy (25%) and Chronic Interstitial Nephritis (10.8%). A shorter duration of diabetes had a statistically significant association with NDRD. Conclusions: Nearly half diabetic patients proposed to kidney biopsy have a NDRD. Since kidney biopsy is essential to establish the diagnosis and subsequently provide adequate treatment, this resource should be used in the diabetic diabetic patient with NDRD suspicion, especially in those with a shorter duration of diabetes. Additional data is necessary to establish which patients should be proposed to earlier kidney biopsies.","PeriodicalId":73669,"journal":{"name":"Journal of clinical nephrology and renal care","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42022788","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-08-26DOI: 10.23937/2572-3286.1510045
Y. Kane, B. Hermann, M. Faye, Ibrahim Hamat, A TallLemrabott, M. Faye, Diama Sakho, Selly Camara Mame, M MoustaphaCisse, S MohamedSeck, Fary Ka El, A. Niang, B. Diouf
{"title":"Quality of Life in Chronic Hemodialysed Patients: Observational Study in Three Hemodialysis Units in Semi-Urban Areas of Senegal (West Africa)","authors":"Y. Kane, B. Hermann, M. Faye, Ibrahim Hamat, A TallLemrabott, M. Faye, Diama Sakho, Selly Camara Mame, M MoustaphaCisse, S MohamedSeck, Fary Ka El, A. Niang, B. Diouf","doi":"10.23937/2572-3286.1510045","DOIUrl":"https://doi.org/10.23937/2572-3286.1510045","url":null,"abstract":"","PeriodicalId":73669,"journal":{"name":"Journal of clinical nephrology and renal care","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47492469","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-05-29DOI: 10.23937/2572-3286.1510043
Rui-Hong Chen, Fengling Song, Yu Gan, Ting-ting Li, L. Ye, Wei Jing Liu, Hua-feng Liu
Transforming growth factor beta1 (TGF-β1) is regarded as the important factor in many fibrotic kidney diseases. Autophagy is a vital mechanism which maintains intracellular homeostasis in eukaryotic cells and involves in various renal physiologic and pathological processes. Current studies indicate that autophagy in renal tubular epithelial cells serves as a renoprotective mechanism which modulates the course of diverse kidney disease. Thus, this review aims to show the possible linkage between TGF-β1 and autophagy in the renal tubular epithelial cells. RevieW ARTiCLe
{"title":"Autophagy and Transforming Growth Factor Beta1 in Renal Tubular Epithelia Cells","authors":"Rui-Hong Chen, Fengling Song, Yu Gan, Ting-ting Li, L. Ye, Wei Jing Liu, Hua-feng Liu","doi":"10.23937/2572-3286.1510043","DOIUrl":"https://doi.org/10.23937/2572-3286.1510043","url":null,"abstract":"Transforming growth factor beta1 (TGF-β1) is regarded as the important factor in many fibrotic kidney diseases. Autophagy is a vital mechanism which maintains intracellular homeostasis in eukaryotic cells and involves in various renal physiologic and pathological processes. Current studies indicate that autophagy in renal tubular epithelial cells serves as a renoprotective mechanism which modulates the course of diverse kidney disease. Thus, this review aims to show the possible linkage between TGF-β1 and autophagy in the renal tubular epithelial cells. RevieW ARTiCLe","PeriodicalId":73669,"journal":{"name":"Journal of clinical nephrology and renal care","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43113230","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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