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SMART Trigger versus Flow and Pressure trigger performance during auto-PEEP 智能触发与流量和压力触发性能在自动peep
Pub Date : 2023-09-15 DOI: 10.53097/jmv.10083
Bradley Fujiuchi, Ehab Daoud
Background Intrinsic positive end-expiratory pressure (auto-PEEP) is a common problem in mechanically ventilated patients, which can lead to adverse effects on patients comfort, hemodynamics, lung mechanics and gas exchange. Triggering systems play a crucial role in the delivery of mechanical ventilation, and advancements in smart triggering technology aim to optimize patient-ventilator synchrony. This bench study aims to compare the performance of the novel SMART Trigger to traditional pressure and flow triggers in the context of auto-PEEP. Methods A lung model simulating severe obstructive pattern with high compliance (80 ml/cmH2O) and high resistance 30 cmH2O/L/s was connected to the Panther 5 ventilator (Origin Medical, California, USA). The mode was set at Volume Controlled with a tidal volume of 700 ml and mandatory breath per min (BPM) of 10/min and Inspiratory time of 2 seconds to intentionally create auto-PEEP. Simulated spontaneous breaths set at 20 BPM with increasing muscle pressure (Pmus) from -1 to maximum of -25 or till full trigger of all breaths. Three different triggering systems were evaluated: SMART Trigger (ST sensitivity 1 to 7), pressure trigger (-1 cmH2O), and flow trigger (1 l/min). The range of auto-PEEP levels induced increased incrementally with the increase in the respiratory rate ranging from 3 cmH2O for 10 BPM, 8 for 15 BPM, to 13 for 20 BPM. The following parameters were assessed for each triggering system: trigger sensitivity (defined as the number of breaths triggered above the mandatory breaths), and the trigger response time (time it takes from the beginning of muscle effort to the initiation of the breath. Results 100% of the breaths were triggered at Pmus (cmH2O) of -15 in the pressure trigger, -25 in flow trigger, -3 for ST1, -9 for ST2, -10 for ST3, -10 for ST4, -12 for ST5, -18 for ST 6, and -22 for ST 7. Trigger time (msec) for flow was 0.135 ± 0.02, for pressure 0.141 ± 0.04, for ST 1-4: 0.076 ± 0.03, for ST 5-7: 0.104 ± 0.04. Multivariate analysis of variance test showed significant difference between the time to trigger P <0.001. Conclusion This bench study highlights the potential advantages of SMART Trigger technology over conventional pressure and flow triggers during auto-PEEP. The SMART Trigger enhanced sensitivity and rapid response might contribute to improved patient-ventilator synchrony. Further research and clinical studies are warranted to validate these findings and explore the impact of smart trigger technology on patient outcomes in real-world scenarios. Keywords: SMART Trigger, Auto-PEEP, Trigger time
本征呼气末正压(auto-PEEP)是机械通气患者的常见问题,可对患者的舒适度、血流动力学、肺力学和气体交换产生不良影响。触发系统在机械通气中起着至关重要的作用,智能触发技术的进步旨在优化患者与呼吸机的同步。本实验旨在比较新型SMART触发器与传统压力和流量触发器在自动peep环境下的性能。方法将高顺应性(80 ml/cmH2O)、高阻力(30 cmH2O/L/s)模拟严重阻塞性肺模型与Panther 5呼吸机(美国加州Origin Medical)连接。模式设置为音量控制,潮汐量为700毫升,每分钟强制呼吸(BPM)为10次/分钟,吸气时间为2秒,有意创建自动peep。模拟自发呼吸,设定为每分钟20次,肌肉压力(Pmus)从-1增加到最大-25,或直到所有呼吸完全触发。评估了三种不同的触发系统:SMART触发器(ST灵敏度1至7),压力触发器(-1 cmH2O)和流量触发器(1 l/min)。随着呼吸频率的增加,诱导的自动peep水平范围逐渐增加,从3 cmH2O为10 BPM, 8 cmH2O为15 BPM, 13 cmH2O为20 BPM。评估每个触发系统的以下参数:触发灵敏度(定义为触发高于强制呼吸的呼吸次数)和触发反应时间(从肌肉开始努力到开始呼吸所需的时间)。结果100%的呼吸在压力触发的Pmus (cmH2O)为-15,流量触发的Pmus为-25,ST1为-3,ST2为-9,ST3为-10,ST4为-10,ST5为-12,st6为-18,st7为-22时触发。流量触发时间(msec)为0.135±0.02,压力触发时间为0.141±0.04,ST 1-4触发时间为0.076±0.03,ST 5-7触发时间为0.104±0.04。多因素方差分析检验显示触发时间P <0.001有显著性差异。本实验强调了SMART触发器技术在自动peep过程中相对于传统压力和流量触发器的潜在优势。SMART Trigger增强的灵敏度和快速反应可能有助于改善患者与呼吸机的同步。需要进一步的研究和临床研究来验证这些发现,并探索智能触发技术在现实世界中对患者预后的影响。关键词:智能触发,自动窥视,触发时间
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引用次数: 0
Identifying asynchronies: Expiratory work 识别异步:过期工作
Pub Date : 2023-09-15 DOI: 10.53097/jmv.10086
Victor Perez, Jamille Pasco
Mechanical ventilation is used to improve gas exchange and unload the respiratory muscles allowing for their rest and recovery, which require good synchronization between the patient and the ventilator. Spontaneous respiratory effort is generally preferred because it reduces atelectasis, improves oxygenation, and may prevent disuse diaphragm atrophy. Nevertheless, vigorous spontaneous effort can cause both lung injury and diaphragm injury (myotrauma). These injuries lead to prolonged ventilation, difficult weaning, and increased morbidity and mortality. Normal expiration is passive due to the recoil of the lungs and chest wall. In mechanical ventilation, during expiration the ventilator controls the pressure (ie, the target value is PEEP), therefore, we must look at the flow and volume waveforms to see the physiology and patient-ventilator interactions. In expiration the patient-ventilation interaction is not characterized by timing but by work. Expiratory effort (ie, negative Pmus) will deform the flow waveform in a negative direction (away from baseline). Keywords: synchronization, spontaneous effort, lung injury, myotrauma, expiratory effort
机械通气用于改善气体交换并卸载呼吸肌,以使其休息和恢复,这需要患者和呼吸机之间的良好同步。自然呼吸通常是首选,因为它可以减少肺不张,改善氧合,并可以防止废用性膈肌萎缩。尽管如此,剧烈的自发努力可能会导致肺损伤和膈肌损伤(肌肉创伤)。这些损伤导致通气时间延长,断奶困难,发病率和死亡率增加。正常呼气是被动的,因为肺部和胸壁会发生反冲。在机械通气中,在呼气期间,呼吸机控制压力(即,目标值为PEEP),因此,我们必须查看流量和体积波形,以了解生理学和患者与呼吸机的相互作用。在呼气中,患者通气的相互作用不是以时间为特征,而是以工作为特征。呼气力(即负Pmus)会使血流波形向负方向(远离基线)变形。关键词:同步性、自发用力、肺损伤、肌肉创伤、呼气用力
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引用次数: 0
Biofilm producer multi drug resistance alert bugs in ventilator associated pneumonia patients. Threat to antibiotic era and future concern 呼吸机相关性肺炎患者的生物膜生产者多重耐药警报细菌。对抗生素时代的威胁和未来的关注
Pub Date : 2023-09-15 DOI: 10.53097/jmv.10082
Karvi Agarwal, RK Verma, DP Singh, Sonal Jindal
Background Emerging threat of drug resistance among Bacteria causing ventilator-associated pneumonia (VAP) has resulted in higher hospital costs, longer hospital stays, and increased hospital mortality. Biofilms in the endotracheal tube of ventilated patients act as protective shield from host immunity for bacterial growth and emerge them as multidrug resistant. Aim To know the prevalence of various bacterial isolates causing VAP, ability to form biofilm and their antibiotic susceptibility pattern. Material & Methods This study was conducted in the department of Microbiology in collaboration with the Respiratory Medicine department for a period of one year (November 2018-19). Endotracheal aspirate (ETA) along with 1 cm tube tip from clinically confirmed VAP patients were processed as per the standard microbiological procedure for the detection of bacterial biofilm formation and their antimicrobial resistance pattern. Statistical Analysis: Data was statistically evaluated using SPSS-PC-20 version. ‘P’ value less than 0.05, considered statistically significant. Results 72 patients with CPIS score > 6 were clinically confirmed as VAP. Various Bacteria isolated were Klebsiella pneumoniae in 52 (53%), Escherichia coli 16 (16.3%), Pseudomonas aeruginosa 14 (14.2%), Acinetobacter spp. 8 (8.1%), Proteus mirabilis 6 (6.1%) and Pseudomonas luteola 2 (2%). All bacterial isolates were processed for their ability to form biofilm, 86 (87.7%) were biofilm producers (BFP) while 12 (12.2%) were biofilm non-producers (BFNP). Conclusion Bacterial etiology, prolonged intubation, biofilm formation, and drug resistance have ramification on outcome of VAP. Keywords: Ventilator associated pneumonia (VAP), CPIS score, Biofilm formation, Tissue culture plate method (TCP), Antimicrobial drug resistance (AMR)
背景:引起呼吸机相关性肺炎(VAP)细菌耐药性的新威胁已导致医院费用增加、住院时间延长和医院死亡率增加。通气患者气管内的生物膜对细菌生长具有宿主免疫的保护作用,并产生多重耐药。目的了解引起VAP的各种分离菌的流行程度、形成生物膜的能力及其对抗生素的敏感性。材料与方法本研究在微生物科与呼吸内科合作进行,为期一年(2018年11月-19日)。根据标准微生物学程序对临床确诊VAP患者的气管内抽吸(ETA)及1 cm管尖进行处理,检测细菌生物膜的形成及其耐药性模式。统计分析:采用SPSS-PC-20版本对数据进行统计分析。“P”值小于0.05,认为具有统计学意义。结果72例CPIS评分bbbb6的患者临床确诊为VAP。分离到的细菌有肺炎克雷伯菌52株(53%)、大肠杆菌16株(16.3%)、铜绿假单胞菌14株(14.2%)、不动杆菌8株(8.1%)、奇异变形杆菌6株(6.1%)和黄苔假单胞菌2株(2%)。对所有分离菌株进行生物膜形成能力分析,86株(87.7%)为生物膜产生菌(BFP), 12株(12.2%)为非生物膜产生菌(BFNP)。结论细菌性病因、插管时间延长、生物膜形成及耐药性对VAP的预后有影响。关键词:呼吸机相关性肺炎(VAP), CPIS评分,生物膜形成,组织培养平板法(TCP),抗微生物药物耐药性(AMR)
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引用次数: 0
The vanishing threat: Stealthy malfunction of closed suction system 消失的威胁:封闭吸入系统的隐形故障
Pub Date : 2023-09-15 DOI: 10.53097/jmv.10085
Akshaya Das, Faisal Qureshi, Surinder Kumar, Nikhil Kothari
This case report presents a rare case of a mechanical ventilation leak that was initially missed by clinicians in a patient with a myxoedema coma. Despite all efforts to investigate the causes of the leak, including a bedside lung ultrasound and chest radiograph, the leak persisted. It was eventually discovered that the rhythmic inflation and deflation of the polythene covering the closed suction system was causing the leak. The closed suction system was replaced with a new one, and the tidal volume was restored, resulting in the resolution of the leak alarm. The volume leak alarm and low volume alarm are important indicators of potential problems during mechanical ventilation, and close suction system malfunction is a potential cause of volume leak that should be considered in mechanically ventilated patients. Regular monitoring and appropriate management of these alarms and potential causes can help prevent complications and optimize patient care. Keywords: Mechanical ventilation, volume leak alarm, closed suction system, and myxoedema coma.
本病例报告介绍了一例罕见的机械通气泄漏病例,临床医生最初在一名黏液水肿昏迷患者中遗漏了该病例。尽管尽了一切努力调查泄漏的原因,包括床边肺部超声和胸部x线片,但泄漏仍然存在。最终发现,覆盖在封闭抽吸系统上的聚乙烯有节奏的膨胀和放气导致了泄漏。将封闭式吸入系统更换为新系统,并恢复了潮气量,从而解决了泄漏警报。容量泄漏警报和低容量警报是机械通气过程中潜在问题的重要指标,闭式抽吸系统故障是机械通气患者应考虑的容量泄漏的潜在原因。对这些警报和潜在原因进行定期监测和适当管理有助于预防并发症并优化患者护理。关键词:机械通气,容量泄漏报警,闭式抽吸系统,黏液水肿昏迷。
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引用次数: 0
The forgotten tale of spontaneous plateau pressure 被遗忘的高原自发压力的故事
Pub Date : 2023-09-15 DOI: 10.53097/jmv.10084
A. Anand
This article highlights the significance of measuring plateau pressure in spontaneously breathing patients as it provides valuable information about PMI (Pmusc Index), which serves as a surrogate for the patient's efforts during mechanical ventilation. The PMI value obtained from the difference between the end-inspiratory occlusion plateau pressure and the airway pressure before the occlusion (PEEP + PS) enables clinicians to estimate the patient's inspiratory effort accurately. The accurate measurement of patient efforts is crucial in optimizing pressure support during lung protective weaning strategies. By titrating pressure support based on PMI values, clinicians can provide personalized care to patients, reducing the risk of ventilator-induced lung injury and enhancing the likelihood of successful weaning. Keywords: PMI, Pmus, Plateau pressure
本文强调了在自主呼吸患者中测量平台压的重要性,因为它提供了关于PMI (Pmusc指数)的有价值的信息,PMI (Pmusc指数)可以替代患者在机械通气期间的努力。通过吸气末闭塞平台压与闭塞前气道压之差(PEEP + PS)得到的PMI值,使临床医生能够准确估计患者的吸气力。在肺保护性脱机策略中,准确测量患者的努力对于优化压力支持至关重要。通过基于PMI值的压力支持滴定,临床医生可以为患者提供个性化护理,降低呼吸机所致肺损伤的风险,提高成功脱机的可能性。关键词:PMI, Pmus,平台压力
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引用次数: 0
Analysis of mechanical power during pressure-controlled ventilation in patients with severe burns 严重烧伤患者压力控制通气过程中的机械功率分析
Pub Date : 2023-06-15 DOI: 10.53097/jmv.10076
Arthur Simonete, Natalia Alberti da Silva, C. Franck
Introduction The clinical evolution of severe burns can lead to Acute Respiratory Distress Syndrome (ARDS) with increased requirements for mechanical ventilation, which may lead to the development of Ventilator-Induced Lung Injury (VILI). Together, ARDS and VILI may cause irreversible lung damage. Mechanical power measures the amount of energy transferred from the ventilator to the respiratory system and is considered to be a unifying concept of the etiology VILI. However, doubts are still to be clarified. The goals of this study were to analyze pressure-controlled ventilation (PCV) in severe burn injury patients, to associate the mechanical power values over time with the outcome of burn patients (death or survival) and to associate the components of ventilation with the outcome of burn patients. Methods A longitudinal, observational and analytical study of 172 measurements of parameters collected daily from the ventilators of 26 severe burn patients undergoing mechanical ventilation with PCV. Statistical analysis was performed on the obtained values and the components of mechanical ventilation in relation to the outcome of the patients. Results The mechanical power calculated daily in burn patients was 22.83 ± SD joule per minute (J/min). Higher values of mechanical power were significantly related to the mortality (P 0.029) regardless of ventilation time, as well as higher values of PEEP, peak pressure, plateau pressure and driving pressure ( P <0.001), respiratory rate (P 0.01), variation of inspiratory pressure (P 0.03) and lower values of tidal volume (P 0.005). Conclusion In this analysis of mechanical ventilation, mean values of mechanical power in burn patients were elevated and that, regardless of mechanical ventilation time, these values are related to mortality, as well as higher values of pressures, driving pressure, respiratory rate and lower values of tidal volume, indicating the importance of stress frequency and propulsion force to overcome lung elastance.
严重烧伤的临床发展可导致急性呼吸窘迫综合征(ARDS),对机械通气的需求增加,这可能导致呼吸机诱导肺损伤(VILI)的发展。ARDS和VILI可能共同造成不可逆的肺损伤。机械功率测量从呼吸机转移到呼吸系统的能量,被认为是VILI病因学的统一概念。然而,仍有疑问有待澄清。本研究的目的是分析严重烧伤患者的压力控制通气(PCV),将机械功率值随时间的变化与烧伤患者的预后(死亡或生存)联系起来,并将通气的组成与烧伤患者的预后联系起来。方法对26例重型烧伤合并PCV机械通气患者呼吸机每日采集的172项参数进行纵向、观察和分析研究。统计分析所得数值及机械通气各组成部分与患者预后的关系。结果烧伤患者每日计算的机械功率为22.83±SD焦耳/分钟(J/min)。与通气时间无关,较高的机械功率与死亡率显著相关(P 0.029);较高的PEEP、峰值压、平台压、驱动压(P <0.001)、呼吸频率(P 0.01)、吸气压力变化(P 0.03)、潮气量较低(P 0.005)。结论在本次机械通气分析中,烧伤患者机械功率平均值升高,且与机械通气时间无关,与死亡率相关,与压力、驱动压力、呼吸频率升高、潮气量降低有关,提示应力频率和推进力对克服肺弹性的重要性。
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引用次数: 1
Exploring clinicians' beliefs and practices regarding Non-Invasive Ventilation devices: An international survey study 探讨临床医生对无创通气装置的信念和实践:一项国际调查研究
Pub Date : 2023-06-15 DOI: 10.53097/jmv.10078
K. Benavente, E. Robbins, Bradley Fujiuchi, K. Manzoor
Introduction Non-invasive ventilation (NIV) has a significant role in supporting patients with respiratory failure with the goal of avoiding mechanical ventilation. Traditionally, NIV has been applied using dedicated NIV-specific devices but over the last decade, newer generation critical care ventilators have updated their capabilities to include NIV options with improved synchrony and leak compensation. No recent trials have compared the efficacy of new generation critical care ventilators to NIV ventilators. The purpose of this study was to evaluate clinicians attitudes and perceptions toward the use of NIV between the dedicated NIV and critical care ventilators. Methods An online survey of clinicians with seven questions regarding their thoughts and experience in using NIV in acute care settings was posted online and promoted through emails and social media. The survey was anonymous and an exemption of consent was obtained from the Institutional Review Board. Analysis of variants (ANOVA) was done for the total responses in each question, followed by multivariate analysis of variants (MANOVA) for responses per occupation. Results 514 responses from 54 countries were recorded. 151 from North America, 109 from South America, 125 from Europe, 97 from Asia, 21 from Africa, and 11 from Australia. 218 responders were physicians, 218 were respiratory therapists, 28 were nurses, and 50 were reported as other professionals (engineers, biomedical technicians). 346 (67.3%) reported using both types of ventilators for NIV, 91 (17.7%) use only NIV -specific devices, and 77 (15%) only use critical care ventilators (P 0.097), responses per occupation (P < 0.001). 290 (56.4%) have automatic synchronization software on either of their ventilators, 113 (22%) do not, while 111 (21.6%) are unsure if they do (P 0.22), with significant variation by occupation (P 0.008). Regarding synchrony, 233 (45.3%) said NIV ventilators are better, and 165 (32.1%) said critical care ventilators are better, while 116 (22.5%) said both are similar (P 0.59) with significant variation by occupation (P 0.04). Regarding leak compensation, 241 (46.9%) said NIV ventilators are better, and 146 (284%) said critical care ventilators are better, while 127 (24.7%) said both are similar (P 0.6) without significant variation by occupation (P 0.07). Regarding the general opinion of superiority, 273 (53.1%) said NIV ventilators are better, 131 (25.5%) said critical care ventilators are better, and 110 (21.4%) said both are similar (P 0.42) without significant variation by occupation (P 0.098). Conclusion Despite the lack of evidence, there is wide variability in opinion with no clear consensus regarding the clinicians’ attitude towards which ventilators are superior to use during NIV, especially according to surveyed occupation.
引言无创通气(NIV)在支持呼吸衰竭患者避免机械通气方面发挥着重要作用。传统上,NIV是使用专用的NIV专用设备应用的,但在过去十年中,新一代重症监护呼吸机已经更新了其功能,包括具有改进的同步性和泄漏补偿的NIV选项。最近没有试验将新一代重症监护呼吸机与NIV呼吸机的疗效进行比较。本研究的目的是评估临床医生对专用NIV和重症监护呼吸机之间使用NIV的态度和看法。方法将一项针对临床医生的在线调查发布在网上,并通过电子邮件和社交媒体进行推广,其中有七个问题涉及他们在急性护理环境中使用NIV的想法和经验。这项调查是匿名的,并获得了机构审查委员会的豁免同意。对每个问题的总回答进行变异分析(ANOVA),然后对每个职业的回答进行变异多变量分析(MANOVA)。结果记录了来自54个国家的514份答复。北美151人,南美109人,欧洲125人,亚洲97人,非洲21人,澳大利亚11人。218名响应者是医生,218名是呼吸治疗师,28名是护士,50名是其他专业人员(工程师、生物医学技术人员)。346例(67.3%)报告使用两种类型的呼吸机治疗NIV,91例(17.7%)仅使用NIV特异性设备,77例(15%)仅使用重症监护呼吸机(P 0.097),每种职业的反应(P<0.001)。290例(56.4%)的呼吸机上有自动同步软件,113例(22%)没有,111例(21.6%)不确定是否有(P 0.22),不同职业的差异显著(P 0.008)。关于同步性,233台(45.3%)表示NIV呼吸机更好,165台(32.1%)表示重症监护呼吸机更好,116台(22.5%)表示两者相似(P 0.59),不同职业的变化显著(P 0.04)。关于泄漏补偿,241台(46.9%)表示NIF呼吸机更好,146台(284%)表示重症监护呼吸机更好,127台(24.7%)表示两者相似(P 0.6),没有职业差异(P 0.07)。关于优势的普遍看法,273台(53.1%)表示NIV呼吸机更好,131台(25.5%)表示危重监护呼吸机更好,110人(21.4%)表示两者相似(P 0.42),但职业差异不显著(P 0.098)。
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引用次数: 0
High Flow Oxygen Therapy – Risks and Rewards 高流量氧气治疗——风险与回报
Pub Date : 2023-06-15 DOI: 10.53097/jmv.10077
Stephen Tunnell
Introduction High Flow Oxygen Therapy via Nasal Cannula (HFNC) has documented advantages over conventional oxygen therapy (COT). It’s been noted to improve the survival rate among patients with acute hypoxemic respiratory failure, and potentially reduce the incidence of more invasive care. Adjustable oxygen concentration and higher flows that match the inspiratory demand of the patient with respiratory distress result in less entrainment of room air, which dilutes the fraction of inspired oxygen (FiO2) and therefore reduces effectiveness of intended use. Higher flows have been demanded by the clinical community and are associated with a reduction of both PaCO2 and metabolic work. Newer High Flow devices offer higher flow rates up to 80 liters per minute. We examined whether the use of 60 and 80 liters per minute set flows would create an increased risk of gastric insufflation and possibly aspiration. Methods Bench study to compare the pressures generated using different flow rates in two commercially available HFNC devices in three different conditions: Open and closed system (mouth) breathing, breathing against active exhalation, and complete downstream occlusion. Results Our bench study found that high flow rate therapy did not elevate airway pressures to a level that would result in gastric distention and potential aspiration. In the open mouth test, the pressure ranged from minimum 0.2 to maximum of 1.3 cmH2O, and from minimum of 0.52 to 5.27 cmH2O in the closed mouth test. In the active breathing test, the pressures ranged from minimum 1.5 to 6 cmH2O. In the complete occlusion test, the pressures ranged from minimum 0.37 to 4.49 cmH2O. Conclusion Flows provided during HFNC therapy do not pose a hazard of creating high pressures which exceed esophageal opening pressure and pose a risk of gastric distention. The higher flow rates may reduce the risk associated with the potential false positive prediction of HFNC failure when therapy is not set to match the patient’s inspiratory peak flow demand. The benefit of higher flows to match the inspiratory demand provides a rarely recognized additional benefit of improving the accuracy of predictive indices such as the ROX index and allows for high flow therapy to more fully achieve its intended use.
经鼻插管的高流量氧疗(HFNC)比传统氧疗(COT)有明显的优势。人们注意到,它可以提高急性低氧性呼吸衰竭患者的存活率,并可能减少更多侵入性护理的发生率。可调节的氧浓度和更高的流量与呼吸窘迫患者的吸气需求相匹配,导致较少的室内空气夹带,这稀释了吸入氧(FiO2)的比例,因此降低了预期使用的有效性。临床社区需要更高的血流,这与PaCO2和代谢工作的减少有关。较新的高流量设备提供更高的流速高达每分钟80升。我们研究了每分钟60升和80升的固定流量是否会增加胃误吸的风险。方法通过台架研究,比较两种市售HFNC设备在开闭系统(口)呼吸、主动呼气呼吸和完全下游闭塞三种不同情况下,不同流量下产生的压力。结果我们的实验研究发现,高流量治疗不会将气道压力升高到导致胃膨胀和潜在误吸的水平。在开口试验中,压力范围从最小0.2到最大1.3 cmH2O,在闭口试验中压力范围从最小0.52到5.27 cmH2O。在主动呼吸试验中,压力范围从最低1.5到6 cmH2O。在完全闭塞试验中,压力范围从最小0.37到4.49 cmH2O。结论HFNC治疗过程中提供的流量不会产生超过食管开口压力的高压和胃膨胀的危险。当治疗设置不符合患者吸气峰值流量需求时,较高的流量可能降低与HFNC失败的潜在假阳性预测相关的风险。与吸气需求相匹配的高流量的好处提供了一个很少被认识到的额外好处,即提高预测指标(如ROX指数)的准确性,并允许高流量治疗更充分地实现其预期用途。
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引用次数: 0
Prone position in pregnant woman with major burns with severe ARDS on mechanical ventilation 重度烧伤合并严重急性呼吸窘迫综合征孕妇俯卧位机械通气
Pub Date : 2023-06-15 DOI: 10.53097/jmv.10079
C. Franck
Burns are skin lesions determined by the thermal energy of heat transfer with cellular protein denaturation. Although infrequent during pregnancy, they can be fatal for both the mother and fetus. The outcome depends on factors related to the burns themselves, such as depth and percentage of body surface burned. Burns that affect more than 20% of the body surface can cause systemic inflammatory response syndrome (SIRS) and acute respiratory distress syndrome (ARDS) with high rates of fetal death and asphyxia. In ARDS, the prone position has been used for over 40 years to promote homogenization of stress distribution and pulmonary strain with improved ventilation/perfusion. However, pregnancy and major burns may constitute relative contraindications related to the prone position due to abdominal and pelvic compression, difficulty in monitoring fetal heartbeats and complications in face and belly burns. The set of contraindications associated with the need for the prone position guided the objective of this case report, which aimed to describe and review the literature to discuss the clinical case, as well as demonstrate the favorable results of gas exchange and ventilatory mechanics in relation to the prone position in pregnant woman with major burns without complications.
烧伤是由细胞蛋白质变性的热传递热能决定的皮肤损伤。尽管在怀孕期间很少发生,但它们对母亲和胎儿都可能致命。结果取决于与烧伤本身相关的因素,如烧伤深度和体表百分比。影响体表20%以上的烧伤可导致全身炎症反应综合征(SIRS)和急性呼吸窘迫综合征(ARDS),胎儿死亡率和窒息率很高。在ARDS中,俯卧位已经使用了40多年,通过改善通气/灌注来促进应力分布和肺部应变的均匀化。然而,由于腹部和骨盆受压、难以监测胎儿心跳以及面部和腹部烧伤并发症,妊娠和严重烧伤可能构成与俯卧位相关的相对禁忌症。与俯卧位需求相关的一组禁忌症指导了本病例报告的目的,该报告旨在描述和回顾文献,以讨论临床病例,并证明气体交换和通气机制在严重烧伤孕妇俯卧位方面的良好效果,没有并发症。
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引用次数: 0
Identifying asynchronies: Delayed triggering 识别异步:延迟触发
Pub Date : 2023-06-15 DOI: 10.53097/jmv.10080
Victor Perez, Jamille Pasco
Patient-ventilator asynchronies can occur at any phase throughout the respiratory cycle. Because it has been associated with patient outcomes, it is important to recognize and address these asynchronies. Bedside interpretation of air flow and airway pressure waveforms are helpful for recognizing patient–ventilator asynchronies and optimizing ventilator settings. Patient effort is sensed by either a drop in circuit pressure (pressure trigger) or circuit bias flow (flow trigger). Triggering delay is the time interval between the start of the neural and mechanical inspiration. Triggers must be sensitive enough to recognize patient effort to avoid imposing an additional load but not too sensitive to avoid auto-triggering. Despite improvements in triggering technology, triggering asynchronies continue to occur and are manifest, among others, by delayed triggering. Keywords: asynchrony, patient effort, trigger, delayed triggering
患者呼吸机不同步可能发生在整个呼吸周期的任何阶段。因为它与患者的结果有关,所以识别和解决这些异步性很重要。对气流和气道压力波形的床边解释有助于识别患者-呼吸机的异步性并优化呼吸机设置。通过回路压力下降(压力触发)或回路偏置流量(流量触发)来感知患者的努力。触发延迟是神经和机械吸气开始之间的时间间隔。触发器必须足够灵敏,能够识别患者的努力,以避免施加额外的负载,但不能过于灵敏,以避免自动触发。尽管触发技术有所改进,但触发异步仍在继续发生,并且通过延迟触发等方式表现出来。关键词:异步、患者努力、触发、延迟触发
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Journal of mechanical ventilation
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