Asif Bilal, Muhammad Imran Anjum, Nimra Naveed, M. Saif-ur-Rehman, Umer Ali, Anisa Iftikhar
Alcohol, heroin, inhalants and similar are considered as drug of abuse in our society. These can ruin the lives of everyone. Infact these are slow poisons. Mostly teen agers are big victims of these drugs. They may be more likely to engage in harmful behavior. Alcohol, cigarettes, and crack cocaine are the most often consumed drugs by young people. Our objectives are to identify the effects of abusing drugs in our society and play a role to stop it. The study was done in the Faisalabad division by the interviews of people who were drug addicts through the questionnaire. This survey research was completed in March 2020 to June 2020. We interviewed about 450 drug addicts and we have found about six abusing drugs among those. The drugs were alcohol, heroin, marijuana, allergic injection, inhalant and opium and the percentage of addicts were 24, 30, 15, 14, 10 and 07 respectively. We also found 9% females and 91% males were involve and 25% were teen ager, 60% were between 20 to 40 years and 15% were above 40 years. It is concluded that authorities should play their role to stop this sin and it should be established a number of centers for treatment of the drug addicts.
{"title":"Impacts of Abusing Drugs on Our Society","authors":"Asif Bilal, Muhammad Imran Anjum, Nimra Naveed, M. Saif-ur-Rehman, Umer Ali, Anisa Iftikhar","doi":"10.52916/JMRS214049","DOIUrl":"https://doi.org/10.52916/JMRS214049","url":null,"abstract":"Alcohol, heroin, inhalants and similar are considered as drug of abuse in our society. These can ruin the lives of everyone. Infact these are slow poisons. Mostly teen agers are big victims of these drugs. They may be more likely to engage in harmful behavior. Alcohol, cigarettes, and crack cocaine are the most often consumed drugs by young people. Our objectives are to identify the effects of abusing drugs in our society and play a role to stop it. The study was done in the Faisalabad division by the interviews of people who were drug addicts through the questionnaire. This survey research was completed in March 2020 to June 2020. We interviewed about 450 drug addicts and we have found about six abusing drugs among those. The drugs were alcohol, heroin, marijuana, allergic injection, inhalant and opium and the percentage of addicts were 24, 30, 15, 14, 10 and 07 respectively. We also found 9% females and 91% males were involve and 25% were teen ager, 60% were between 20 to 40 years and 15% were above 40 years. It is concluded that authorities should play their role to stop this sin and it should be established a number of centers for treatment of the drug addicts.","PeriodicalId":73820,"journal":{"name":"Journal of medical research and surgery","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44879295","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-04-01Epub Date: 2021-04-12DOI: 10.52916/jmrs214042
Bobby Garcia, Afiba Arthur, Bansari Patel, Jenny Chang, Dongbao Chen, Felicia Lane
Objectives: The aim of this study was to determine if lysyl oxidase-like 1 (LOXL1) and Fibulin-5 (Fib-5), two crucial proteins in the elastin metabolism pathway, are detectable in the vaginal secretions of women with and without pelvic organ prolapse (POP). We then sought to quantify levels of these proteins in relation to prolapse.
Methods: Vaginal secretions were obtained from 48 subjects (13 (27.1%) without and 35 (72.9%) with POP-Q Stage 2-4 prolapse). Eleven (22.9%) subjects were premenopausal and 37 (77.1%) were postmenopausal. Presence of LOXL-1 and Fibulin-5 within specimens were first identified via western blotting. Enzyme-Linked Immunosorbent Assays specific for LOXL1 and Fibulin-5 were conducted to quantify total protein secretion.
Results: LOXL1 was detected in 45/48 (93.8%) and Fibulin-5 was seen in 24/48 (50%) of subjects. LOXL1 values were lower in women without prolapse (13.3 ng/100 mg median, 24.4 IQR) vs. those with prolapse (26.4 ng/100 mg, 102.2 IQR). On multivariate analysis controlling for age, women with prolapse had a 544% (p=0.0042 higher LOXL1 protein level compared to those without. There was no significant differences in LOXL1 or Fibulin-5 protein detection with relation to menopausal status in bivariate analysis.
Conclusions: This is the first published report of non-invasively measuring urogenital LOXL1 and Fibulin-5. In vaginal secretions, LOXL1 protein is higher in subjects with POP than those without.
{"title":"A Non-Invasive Determination of LOXL1 and Fibulin-5 Levels in the Vaginal Secretions of Women with and Without Pelvic Organ Prolapse.","authors":"Bobby Garcia, Afiba Arthur, Bansari Patel, Jenny Chang, Dongbao Chen, Felicia Lane","doi":"10.52916/jmrs214042","DOIUrl":"https://doi.org/10.52916/jmrs214042","url":null,"abstract":"<p><strong>Objectives: </strong>The aim of this study was to determine if lysyl oxidase-like 1 (LOXL1) and Fibulin-5 (Fib-5), two crucial proteins in the elastin metabolism pathway, are detectable in the vaginal secretions of women with and without pelvic organ prolapse (POP). We then sought to quantify levels of these proteins in relation to prolapse.</p><p><strong>Methods: </strong>Vaginal secretions were obtained from 48 subjects (13 (27.1%) without and 35 (72.9%) with POP-Q Stage 2-4 prolapse). Eleven (22.9%) subjects were premenopausal and 37 (77.1%) were postmenopausal. Presence of LOXL-1 and Fibulin-5 within specimens were first identified via western blotting. Enzyme-Linked Immunosorbent Assays specific for LOXL1 and Fibulin-5 were conducted to quantify total protein secretion.</p><p><strong>Results: </strong>LOXL1 was detected in 45/48 (93.8%) and Fibulin-5 was seen in 24/48 (50%) of subjects. LOXL1 values were lower in women without prolapse (13.3 ng/100 mg median, 24.4 IQR) vs. those with prolapse (26.4 ng/100 mg, 102.2 IQR). On multivariate analysis controlling for age, women with prolapse had a 544% (p=0.0042 higher LOXL1 protein level compared to those without. There was no significant differences in LOXL1 or Fibulin-5 protein detection with relation to menopausal status in bivariate analysis.</p><p><strong>Conclusions: </strong>This is the first published report of non-invasively measuring urogenital LOXL1 and Fibulin-5. In vaginal secretions, LOXL1 protein is higher in subjects with POP than those without.</p>","PeriodicalId":73820,"journal":{"name":"Journal of medical research and surgery","volume":"2 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8312730/pdf/nihms-1698263.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39229222","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
This paper discusses the statistical measurement of the impact of COVID-19 major emergencies on farmers’ economic income in Hubei Province. Hubei Province was selected as the object of analysis, and five data of total output value of agriculture, forestry, animal husbandry, fishery and per capita disposable income of farmers in Hubei Province from the first quarter of 2013 to the second quarter of 2020 were collected by using the Internet. Since all the collected data were macroeconomic data, these data were taken the logarithm to meet the economic significance. The per capita disposable income of farmers was taken as the response variable, and the main factors affecting farmers’ income were obtained by factor analysis. Livestock husbandry and fishery industries were the main industries in Hubei Province. Then the score of factor analysis were taken as explained variable to establish a regression model composed of influencing factors. This paper uses the multiple linear regression, support vector regression to fitting and forecasting data, ARIMA model of time series analysis, introduced at the same time, through the AIC model choice, with the first quarter of 2013 to 2019 in the second quarter fitting training, backward prediction two quarters, and three or four quarter of 2019 compared with the real data, through to the predicted results of the sequence diagram and evaluation index model to compare the mean square error (RMSE). Three models predict per capita disposable income of farmers in the first and second quarter of 2020. It has been found that performance better ARIMA model in the model compare is worse than before, and three kinds of predicted values are higher than the real value of the model, showed the outbreak to the influence of the agricultural economy in Hubei province is serious. On this basis, taking into account the characteristics of geomorphic climate in Hubei province, constructive suggestions are put forward.
{"title":"On farmers’ Economic Income in Hubei Province of China During the COVID-19 Epidemic","authors":"Bin Zhao, Jinming Cao","doi":"10.52916/JMRS214038","DOIUrl":"https://doi.org/10.52916/JMRS214038","url":null,"abstract":"This paper discusses the statistical measurement of the impact of COVID-19 major emergencies on farmers’ economic income in Hubei Province. Hubei Province was selected as the object of analysis, and five data of total output value of agriculture, forestry, animal husbandry, fishery and per capita disposable income of farmers in Hubei Province from the first quarter of 2013 to the second quarter of 2020 were collected by using the Internet. Since all the collected data were macroeconomic data, these data were taken the logarithm to meet the economic significance. The per capita disposable income of farmers was taken as the response variable, and the main factors affecting farmers’ income were obtained by factor analysis. Livestock husbandry and fishery industries were the main industries in Hubei Province. Then the score of factor analysis were taken as explained variable to establish a regression model composed of influencing factors. This paper uses the multiple linear regression, support vector regression to fitting and forecasting data, ARIMA model of time series analysis, introduced at the same time, through the AIC model choice, with the first quarter of 2013 to 2019 in the second quarter fitting training, backward prediction two quarters, and three or four quarter of 2019 compared with the real data, through to the predicted results of the sequence diagram and evaluation index model to compare the mean square error (RMSE). Three models predict per capita disposable income of farmers in the first and second quarter of 2020. It has been found that performance better ARIMA model in the model compare is worse than before, and three kinds of predicted values are higher than the real value of the model, showed the outbreak to the influence of the agricultural economy in Hubei province is serious. On this basis, taking into account the characteristics of geomorphic climate in Hubei province, constructive suggestions are put forward.","PeriodicalId":73820,"journal":{"name":"Journal of medical research and surgery","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-02-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43588077","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
“Diarrhea” is an alteration in a normal bowel movement characterized by an increase in the water content, volume or frequency of stools. Acute diarrhea of infectious etiology often referred to as gastroenteritis and is typically associated with clinical signs and symptoms including nausea, vomiting, abdominal pain and cramps, bloating, flatulence, fever, the passage of bloody stools, tenesmus, and fecal urgency. Infectious diarrheal diseases are the second leading cause of morbidity and mortality worldwide. It is diarrhea we have also found out during a large 3 years study 2017-2020 in TransylvaniaRomania. 3577 number of cases were transmitted during this time by the 12 territory sanitary policies to the Epidemiology Department from the Public Health Center Cluj. Those were mostly diagnosed by the territorial family doctors in the region and more than 20%, needed hospitalization for several days because of the mentioned disease disorders 3 children died during this time because of severe complications. The detected infectious microbial etiology were determined in authorized laboratories in which it was identified as Shigella spp., Salmonella spp., Campylobacter spp. and Yersinia spp. or Rotavirus Giardia and Fungi species. Most numbers of cases appeared in children, followed by elderly or adult people, as quantified number of determination. In light of these data, acute diarrheal illness had to be considered a major public health issue against which control efforts are needed. Public health surveillance and response in the field of infectious acute diarrhea include obligatory strategies of infection control.
{"title":"Study of Infectious Diarrheas in Transylvania-Romania","authors":"L. Deac","doi":"10.52916/jmrs214039","DOIUrl":"https://doi.org/10.52916/jmrs214039","url":null,"abstract":"“Diarrhea” is an alteration in a normal bowel movement characterized by an increase in the water content, volume or frequency of stools. Acute diarrhea of infectious etiology often referred to as gastroenteritis and is typically associated with clinical signs and symptoms including nausea, vomiting, abdominal pain and cramps, bloating, flatulence, fever, the passage of bloody stools, tenesmus, and fecal urgency. Infectious diarrheal diseases are the second leading cause of morbidity and mortality worldwide. It is diarrhea we have also found out during a large 3 years study 2017-2020 in TransylvaniaRomania. 3577 number of cases were transmitted during this time by the 12 territory sanitary policies to the Epidemiology Department from the Public Health Center Cluj. Those were mostly diagnosed by the territorial family doctors in the region and more than 20%, needed hospitalization for several days because of the mentioned disease disorders 3 children died during this time because of severe complications. The detected infectious microbial etiology were determined in authorized laboratories in which it was identified as Shigella spp., Salmonella spp., Campylobacter spp. and Yersinia spp. or Rotavirus Giardia and Fungi species. Most numbers of cases appeared in children, followed by elderly or adult people, as quantified number of determination. In light of these data, acute diarrheal illness had to be considered a major public health issue against which control efforts are needed. Public health surveillance and response in the field of infectious acute diarrhea include obligatory strategies of infection control.","PeriodicalId":73820,"journal":{"name":"Journal of medical research and surgery","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42398145","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The thrombosis in areas of the superficial truncal varicose veins and cutaneous veins is not a rare complication; it requires drug or surgical therapy if the thrombosis grows in the direction of deep veins. This situation is particularly striking in the case of thromboses of the great saphenous vein GSV and small saphenous vein SSV as well as other saphenous veins and leads to deep vein thrombosis in around 20% of cases. We will report about a case of SSV thrombosis and the catheter-based therapy of thrombosis following the therapy of truncal varicose vein SSV with VenaSeal® in one session.
{"title":"Vein Glue VenaSeal® for the Therapy in Case of Varicose Vein Thrombosis: A Case Report","authors":"Zierau Ut","doi":"10.52916/JMRS214037","DOIUrl":"https://doi.org/10.52916/JMRS214037","url":null,"abstract":"The thrombosis in areas of the superficial truncal varicose veins and cutaneous veins is not a rare complication; it requires drug or surgical therapy if the thrombosis grows in the direction of deep veins. This situation is particularly striking in the case of thromboses of the great saphenous vein GSV and small saphenous vein SSV as well as other saphenous veins and leads to deep vein thrombosis in around 20% of cases. We will report about a case of SSV thrombosis and the catheter-based therapy of thrombosis following the therapy of truncal varicose vein SSV with VenaSeal® in one session.","PeriodicalId":73820,"journal":{"name":"Journal of medical research and surgery","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44559814","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The suprascapular notch, a depression on the lateral part of the superior border of the scapula, medial to the coracoid process, is covered by the superior transverse scapular ligament, which is converted into a foramen. Sometimes it might be ossified forming a complete osseous foramen. The Suprascapular Notch (SN) served as a passage for the Suprascapular Nerve (SSN). Study the morphology of the suprascapular notch and the suprascapular transverse ligament based on MRI, variations in shape and dimensions of the suprascapular notch. A group of 100 patients underwent MRI examination of the scapular region through the period from 10th July 2019 to 15th Feb 2020. Different morphological types of the suprascapular notch were encountered in the study, the most common type was type III, while type I was less common in the study. The symmetry of the morphological feature of SN bilaterally was seen in 51% of the cases. Conclusively, the symmetry of the suprascapular notch is not a constant feature bilaterally.
{"title":"MRI-Evaluation of Suprascapular Notch Morphometry and Its Clinical Applications","authors":"Thaer M Farhan, Huda R. Kamoona","doi":"10.52916/JMRS214036","DOIUrl":"https://doi.org/10.52916/JMRS214036","url":null,"abstract":"The suprascapular notch, a depression on the lateral part of the superior border of the scapula, medial to the coracoid process, is covered by the superior transverse scapular ligament, which is converted into a foramen. Sometimes it might be ossified forming a complete osseous foramen. The Suprascapular Notch (SN) served as a passage for the Suprascapular Nerve (SSN). Study the morphology of the suprascapular notch and the suprascapular transverse ligament based on MRI, variations in shape and dimensions of the suprascapular notch. A group of 100 patients underwent MRI examination of the scapular region through the period from 10th July 2019 to 15th Feb 2020. Different morphological types of the suprascapular notch were encountered in the study, the most common type was type III, while type I was less common in the study. The symmetry of the morphological feature of SN bilaterally was seen in 51% of the cases. Conclusively, the symmetry of the suprascapular notch is not a constant feature bilaterally.","PeriodicalId":73820,"journal":{"name":"Journal of medical research and surgery","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42267153","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Background: A surge of cases of Coronavirus Disease 2019 (COVID-19)-Associated Mucormycosis (CAM) was recently observed. Objective: To determine the contribution of diabetes and glucocorticoid therapy in predisposing to CAM. Methods: Pubmed search until July 2nd, 2021. Search terms included mucormycosis, diabetes, glucocorticoids, corticosteroids, coronavirus disease 2019, mortality. Randomized trials, case series, retrospective, pre-print studies, meta-analysis, professional guidelines are reviewed. Pertinent in vitro and animal studies are also included. Results: Diabetes mellitus was reported in 78-85% of cases of CAM worldwide, with the highest rates present in India. Diabetic Ketoacidosis (DKA) was observed in 3.5-41% of cases of CAM. Glucocorticoid therapy emerged as another predisposing factor occurring in 85% of cases of CAM. Injudicious use of glucocorticoids may be a contributing factor in a substantial proportion of subjects with CAM. Majority of patients develop symptoms of CAM between day 10 and 15 from the diagnosis of COVID-19. However, some cases of CAM may present up to 3 months after COVID-19 or following recovery from COVID-19. Mortality rates of CAM overall ranges from 34-48%. Surgical debridement may be associated with improved survival. Conclusions: High index of suspicion for CAM should be present in patients with diabetes and those receiving corticosteroids. Effective glycemic control and judicious use of glucocorticoids should be implemented to decrease incidence of CAM.
{"title":"Diabetes Mellitus and Glucocorticoid Use As Risk Factors for COVID-19 Associated Mucormycosis","authors":"N. Mikhail, Soma Wali","doi":"10.52916/jmrs214051","DOIUrl":"https://doi.org/10.52916/jmrs214051","url":null,"abstract":"Background: A surge of cases of Coronavirus Disease 2019 (COVID-19)-Associated Mucormycosis (CAM) was recently observed. Objective: To determine the contribution of diabetes and glucocorticoid therapy in predisposing to CAM. Methods: Pubmed search until July 2nd, 2021. Search terms included mucormycosis, diabetes, glucocorticoids, corticosteroids, coronavirus disease 2019, mortality. Randomized trials, case series, retrospective, pre-print studies, meta-analysis, professional guidelines are reviewed. Pertinent in vitro and animal studies are also included. Results: Diabetes mellitus was reported in 78-85% of cases of CAM worldwide, with the highest rates present in India. Diabetic Ketoacidosis (DKA) was observed in 3.5-41% of cases of CAM. Glucocorticoid therapy emerged as another predisposing factor occurring in 85% of cases of CAM. Injudicious use of glucocorticoids may be a contributing factor in a substantial proportion of subjects with CAM. Majority of patients develop symptoms of CAM between day 10 and 15 from the diagnosis of COVID-19. However, some cases of CAM may present up to 3 months after COVID-19 or following recovery from COVID-19. Mortality rates of CAM overall ranges from 34-48%. Surgical debridement may be associated with improved survival. Conclusions: High index of suspicion for CAM should be present in patients with diabetes and those receiving corticosteroids. Effective glycemic control and judicious use of glucocorticoids should be implemented to decrease incidence of CAM.","PeriodicalId":73820,"journal":{"name":"Journal of medical research and surgery","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71107700","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pulsed Electromagnetic Field (PEMF) therapy is a non-invasive and non-thermal treatment widely used nowadays to treat various types of disorders and traumas, both in humans and animals. Initially applied only for wound healing, today it finds many applications in medicine for the treatment of bone fractures, arthritis, inflammation, edema, and pain. Although their mechanisms of action are still being studied today, and mainly related to the calcium signaling pathway, they are effective in the adjuvant treatment of many human diseases in different medical specialties. This work aims to report the main evidence and research in the medical field with particular reference to the application of PEMF to some medical specialties as regenerative medicine (wound care), sports medicine, orthopedics, and physiotherapy. Finally, this work also wanted to deepen one of the most recent applications of PEMF in the field of complex diseases, i.e. in the adjuvant treatment of cancer. Pulsed electromagnetic field therapy may play an important role in medicine as a complementary treatment for various human diseases and, by deepening the studies in the future, it will be possible not only to understand the exact mechanisms of action but also to extend its application to other pathologies both in the medical and veterinary fields.
{"title":"Mechanisms of Action And Effects of Pulsed Electromagnetic Fields (PEMF) in Medicine","authors":"Cristiano Luigi, P. Tiziano","doi":"10.52916/JMRS204033","DOIUrl":"https://doi.org/10.52916/JMRS204033","url":null,"abstract":"Pulsed Electromagnetic Field (PEMF) therapy is a non-invasive and non-thermal treatment widely used nowadays to treat various types of disorders and traumas, both in humans and animals. Initially applied only for wound healing, today it finds many applications in medicine for the treatment of bone fractures, arthritis, inflammation, edema, and pain. Although their mechanisms of action are still being studied today, and mainly related to the calcium signaling pathway, they are effective in the adjuvant treatment of many human diseases in different medical specialties. This work aims to report the main evidence and research in the medical field with particular reference to the application of PEMF to some medical specialties as regenerative medicine (wound care), sports medicine, orthopedics, and physiotherapy. Finally, this work also wanted to deepen one of the most recent applications of PEMF in the field of complex diseases, i.e. in the adjuvant treatment of cancer. Pulsed electromagnetic field therapy may play an important role in medicine as a complementary treatment for various human diseases and, by deepening the studies in the future, it will be possible not only to understand the exact mechanisms of action but also to extend its application to other pathologies both in the medical and veterinary fields.","PeriodicalId":73820,"journal":{"name":"Journal of medical research and surgery","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-12-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41686189","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Objective: To evaluate the incidence of Microsatellite Instability (MSI) in patients with Colon Cancer in stage II & III in the Mexican population. Methods: This is a descriptive, retrospective and cross-sectional study performed through a review of 30 clinical charts of patients with the diagnosis of Colorectal Cancer and evaluation of Microsatellite Instability in surgical pathology specimens. Results: Males with 53.3% had a higher incidence than females. The most frequent site was the left colon (53%), followed by the right colon (16.6%), higher rectum (10%), mid rectum (10%), and lower rectum (10%). The majority of the patient were classified as moderately differentiated (86.7%), with 6.7% being poorly differentiated and the rest 6.7% well differentiated. For the presence of MSI in repair genes (MLH1, MSH2, PMS2), this was positive in 33% of the population studied. The clinical-stage most frequently affected was IIA with 36.7% of the positive cases followed by stage IIB with 20%, stage IIIA 20%, and finally, stage IIC and IIIB with 13% and 10% respectively. Among histologic subtypes, adenocarcinoma was found in 90% of the cases, mucinous carcinoma in 6.7%, and signet ring cell carcinoma in 3.3%. In regards to treatment, 50 % of patients underwent only surgery while the other 50% were treated with surgery followed by adjuvant chemotherapy. Clean surgical margins were achieved in 93.7% after initial surgery and the rest were taken back to surgery for a wider resection. The predominant tumor size was T2 (50%), T3 (33%), and T4a (16.7%). The most commonly found lymph node involvement was N1a with 63.3% of the cases followed by N1b with 16.7%. In terms of recurrent metastatic disease, M1a was the most frequent, found in 73.3% of the cases. Conclusion: In our study population in contrast with current literature from the rest of the world we found a higher presence of microsatellite instability (33% vs 15%) and a higher incidence in the left colon with a definitive impact in the survival of patients.
{"title":"Microsatellite Instability Incidence in Recurrent Colon Cancer Stage II and III","authors":"Guzmán-Casta Jordi","doi":"10.52916/JMRS204034","DOIUrl":"https://doi.org/10.52916/JMRS204034","url":null,"abstract":"Objective: To evaluate the incidence of Microsatellite Instability (MSI) in patients with Colon Cancer in stage II & III in the Mexican population. Methods: This is a descriptive, retrospective and cross-sectional study performed through a review of 30 clinical charts of patients with the diagnosis of Colorectal Cancer and evaluation of Microsatellite Instability in surgical pathology specimens. Results: Males with 53.3% had a higher incidence than females. The most frequent site was the left colon (53%), followed by the right colon (16.6%), higher rectum (10%), mid rectum (10%), and lower rectum (10%). The majority of the patient were classified as moderately differentiated (86.7%), with 6.7% being poorly differentiated and the rest 6.7% well differentiated. For the presence of MSI in repair genes (MLH1, MSH2, PMS2), this was positive in 33% of the population studied. The clinical-stage most frequently affected was IIA with 36.7% of the positive cases followed by stage IIB with 20%, stage IIIA 20%, and finally, stage IIC and IIIB with 13% and 10% respectively. Among histologic subtypes, adenocarcinoma was found in 90% of the cases, mucinous carcinoma in 6.7%, and signet ring cell carcinoma in 3.3%. In regards to treatment, 50 % of patients underwent only surgery while the other 50% were treated with surgery followed by adjuvant chemotherapy. Clean surgical margins were achieved in 93.7% after initial surgery and the rest were taken back to surgery for a wider resection. The predominant tumor size was T2 (50%), T3 (33%), and T4a (16.7%). The most commonly found lymph node involvement was N1a with 63.3% of the cases followed by N1b with 16.7%. In terms of recurrent metastatic disease, M1a was the most frequent, found in 73.3% of the cases. Conclusion: In our study population in contrast with current literature from the rest of the world we found a higher presence of microsatellite instability (33% vs 15%) and a higher incidence in the left colon with a definitive impact in the survival of patients.","PeriodicalId":73820,"journal":{"name":"Journal of medical research and surgery","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-11-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48075775","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Guzmán-Casta Jordi, Alatorre-Alexander Jorge Arturo, Carrasco-CaraChards Sonia, Guzmán-Huesca Jorge, Riera-Sala Rodrigo, S. Paola, Peña-Mirabal Erika Sagrario, Hernández-Dehesa Itzel Ariadna, Baltazar-Contreras Rocíodel Carmen, Martínez-Barrera Luis Manuel, Rodríguez-Cid Jerónimo Rafael
Primary sarcomas of the thorax are rare. They are classified according to their histologic features and constitute a large group of tumors that occur in the lung, mediastinum, pleura, and chest wall. Although primary thoracic sarcomas commonly manifest as large, heterogeneous masses, they have a wide spectrum of radiologic manifestations, including solitary pulmonary nodules, central endobronchial tumors, and intraluminal masses within the pulmonary arteries. Angiosarcomas are rare, malignant vascular tumors, representing about 2% of all soft tissue sarcomas. The most frequently primarily affected sites include the heart, liver, breast, skin, and scalp, and they have a high rate of metastases to the lungs and, less commonly, liver, regional lymph nodes, and bone. Definitive diagnosis is made based on histopathological and immunohistochemical findings. No standard treatment regimen has been established for pulmonary angiosarcoma. Radiation therapy, chemotherapy, surgical resection, and immunotherapy have been attempted. The use of radiation therapy in conjunction with surgery has resulted in local control and excellent functional and cosmetic outcome, for patients with angiosarcoma of the head and neck, but not the lung. For advanced-stage disease, other than the combination of doxorubicin and ifosfamide-based regimens, there have been few other chemotherapeutic options for the treatment of local or metastatic angiosarcoma.
{"title":"Primary Pulmonary Angiosarcoma: A Case Report and Literature Review","authors":"Guzmán-Casta Jordi, Alatorre-Alexander Jorge Arturo, Carrasco-CaraChards Sonia, Guzmán-Huesca Jorge, Riera-Sala Rodrigo, S. Paola, Peña-Mirabal Erika Sagrario, Hernández-Dehesa Itzel Ariadna, Baltazar-Contreras Rocíodel Carmen, Martínez-Barrera Luis Manuel, Rodríguez-Cid Jerónimo Rafael","doi":"10.52916/jmrs204028","DOIUrl":"https://doi.org/10.52916/jmrs204028","url":null,"abstract":"Primary sarcomas of the thorax are rare. They are classified according to their histologic features and constitute a large group of tumors that occur in the lung, mediastinum, pleura, and chest wall. Although primary thoracic sarcomas commonly manifest as large, heterogeneous masses, they have a wide spectrum of radiologic manifestations, including solitary pulmonary nodules, central endobronchial tumors, and intraluminal masses within the pulmonary arteries. Angiosarcomas are rare, malignant vascular tumors, representing about 2% of all soft tissue sarcomas. The most frequently primarily affected sites include the heart, liver, breast, skin, and scalp, and they have a high rate of metastases to the lungs and, less commonly, liver, regional lymph nodes, and bone. Definitive diagnosis is made based on histopathological and immunohistochemical findings. No standard treatment regimen has been established for pulmonary angiosarcoma. Radiation therapy, chemotherapy, surgical resection, and immunotherapy have been attempted. The use of radiation therapy in conjunction with surgery has resulted in local control and excellent functional and cosmetic outcome, for patients with angiosarcoma of the head and neck, but not the lung. For advanced-stage disease, other than the combination of doxorubicin and ifosfamide-based regimens, there have been few other chemotherapeutic options for the treatment of local or metastatic angiosarcoma.","PeriodicalId":73820,"journal":{"name":"Journal of medical research and surgery","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48418680","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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