Pub Date : 2023-01-01Epub Date: 2023-07-10DOI: 10.47363/jnrrr/2023(5)178
Javed Iqbal, Abdullah Naeem, Kainat Jahangir, Yumna Ali, Yusra Mashkoor, Ahmer Ashraf, Dalia Mehmood, Maria Mehmood, Lucke-Wold Brandon
Introduction: Hyperbaric oxygen therapy (HBO2) aims to address ischemia resulting from brain injury by subjecting patients to an atmosphere that dramatically raises the concentration of inspired oxygen (100% O2 at greater than 1 ATA). This results in elevated levels of oxygen in the plasma, which in turn boosts the delivery of oxygen for diffusion to the brain tissue.
Objective: To study the efficacy of hyperbaric oxygen (HBO)-based modalities in brain injury.
Method: Preferred reporting items for systematic reviews protocol was applied to perform literature search regarding this analytical review.
Results: In our study, fifteen studies are included in this review, involving 1067 people. The mean age group of patients enrolled was 57.0±11.6 and the mean NIHSS score was 10.5±8.7, of which 21 participants had moderate to severe neurological impairment. The total number of HBO treatments was 8 to 70 times (28.3±17.9), at the end of the 6-month follow-up period. mRS (modified Rankin scale) ≤3 was found in 25 cases, of which 12 patients with high-grade aSAH recovered. Poor prognosis was prevalent in patients who experienced delayed cerebral ischemia, this was true for 22.7% of patients in this study. In 3 studies conducted by Rockswold, ICP (mm Hg) was significantly lower in the HBO2 group after the treatment than pretreatment. (p<0.05). 4 studies showed an improvement in GCS score after HBO2 therapy.One trial (Imai 2006) reported that three patients in the HBO group died due to pneumonia (two) and heart failure (one) and one patient died in the control group due to heart failure. Overall, it is relatively safe to use HBO in the treatment of brain-related haemorrhage, strokes, and injury as there were no major complications reported.
Conclusion: This systematic review demonstrates that HBO2 has significant clinical potential in treatment of brain related haemorrhages, stroke and injury.
{"title":"Hyperbaric Oxygen and Outcomes Following the Brain Injury: A Systematic Review.","authors":"Javed Iqbal, Abdullah Naeem, Kainat Jahangir, Yumna Ali, Yusra Mashkoor, Ahmer Ashraf, Dalia Mehmood, Maria Mehmood, Lucke-Wold Brandon","doi":"10.47363/jnrrr/2023(5)178","DOIUrl":"10.47363/jnrrr/2023(5)178","url":null,"abstract":"<p><strong>Introduction: </strong>Hyperbaric oxygen therapy (HBO2) aims to address ischemia resulting from brain injury by subjecting patients to an atmosphere that dramatically raises the concentration of inspired oxygen (100% O2 at greater than 1 ATA). This results in elevated levels of oxygen in the plasma, which in turn boosts the delivery of oxygen for diffusion to the brain tissue.</p><p><strong>Objective: </strong>To study the efficacy of hyperbaric oxygen (HBO)-based modalities in brain injury.</p><p><strong>Method: </strong>Preferred reporting items for systematic reviews protocol was applied to perform literature search regarding this analytical review.</p><p><strong>Results: </strong>In our study, fifteen studies are included in this review, involving 1067 people. The mean age group of patients enrolled was 57.0±11.6 and the mean NIHSS score was 10.5±8.7, of which 21 participants had moderate to severe neurological impairment. The total number of HBO treatments was 8 to 70 times (28.3±17.9), at the end of the 6-month follow-up period. mRS (modified Rankin scale) ≤3 was found in 25 cases, of which 12 patients with high-grade aSAH recovered. Poor prognosis was prevalent in patients who experienced delayed cerebral ischemia, this was true for 22.7% of patients in this study. In 3 studies conducted by Rockswold, ICP (mm Hg) was significantly lower in the HBO2 group after the treatment than pretreatment. (p<0.05). 4 studies showed an improvement in GCS score after HBO2 therapy.One trial (Imai 2006) reported that three patients in the HBO group died due to pneumonia (two) and heart failure (one) and one patient died in the control group due to heart failure. Overall, it is relatively safe to use HBO in the treatment of brain-related haemorrhage, strokes, and injury as there were no major complications reported.</p><p><strong>Conclusion: </strong>This systematic review demonstrates that HBO2 has significant clinical potential in treatment of brain related haemorrhages, stroke and injury.</p>","PeriodicalId":73862,"journal":{"name":"Journal of neurology research, reviews & reports","volume":"5 7","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9996729","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-02-28DOI: 10.47363/jnrrr/2022(4)150
Anna Ma Gabrielle S. de Castro, Criscely L. Go
Background: During the COVID-19 pandemic, there is an increase in demand of telemedicine for safer consultations to minimize potential exposure for both patient and healthcare providers. it is important to determine the patient satisfaction level to continuously improve this experience. Methods: In this study, descriptive statistics using summary measures were used to describe the socio-demographic profiles of neurology patients who sought consultation through telemedicine in the Jose R. Reyes Memorial Medical Center, Department of Neurology from September 2021 to October 2021. T-tests and analysis of variance (ANOVA) were used to determine statistically significant differences between the type of visit and amongst the top four diagnosis seen, respectively. Results: The respondents are composed of 54% females and 46% males with ages ranging from 19 to 83 years old. One-third of the respondents are new patients, and the rest are follow-up visits. Conclusion: The t-test and ANOVA showed that there are no significant differences in the mean level of overall satisfaction between the type of visit (p-value = 0.9117) and among the top four diagnosis (p-value = 0.3371)
背景:在2019冠状病毒病大流行期间，为了更安全的会诊，对远程医疗的需求有所增加，以尽量减少患者和医疗保健提供者的潜在暴露。确定患者满意度对于持续改善这种体验非常重要。方法:本研究采用描述性统计方法，对2021年9月至2021年10月在Jose R. Reyes纪念医疗中心神经内科通过远程医疗就诊的神经病学患者的社会人口特征进行汇总统计。t检验和方差分析(ANOVA)分别用于确定就诊类型和前四种诊断之间的统计学显著差异。结果:受访者中女性占54%，男性占46%，年龄在19 ~ 83岁之间。三分之一的受访者是新患者，其余是随访者。结论:经t检验和方差分析，就诊类型与前4种诊断之间的总体满意度均值差异无统计学意义(p值= 0.9117)，p值= 0.3371。
{"title":"Satisfaction Rates on Telemedicine Consultations among Neurology Patients Seen at A Tertiary Hospital: A Cross- Sectional Study","authors":"Anna Ma Gabrielle S. de Castro, Criscely L. Go","doi":"10.47363/jnrrr/2022(4)150","DOIUrl":"https://doi.org/10.47363/jnrrr/2022(4)150","url":null,"abstract":"Background: During the COVID-19 pandemic, there is an increase in demand of telemedicine for safer consultations to minimize potential exposure for both patient and healthcare providers. it is important to determine the patient satisfaction level to continuously improve this experience. Methods: In this study, descriptive statistics using summary measures were used to describe the socio-demographic profiles of neurology patients who sought consultation through telemedicine in the Jose R. Reyes Memorial Medical Center, Department of Neurology from September 2021 to October 2021. T-tests and analysis of variance (ANOVA) were used to determine statistically significant differences between the type of visit and amongst the top four diagnosis seen, respectively. Results: The respondents are composed of 54% females and 46% males with ages ranging from 19 to 83 years old. One-third of the respondents are new patients, and the rest are follow-up visits. Conclusion: The t-test and ANOVA showed that there are no significant differences in the mean level of overall satisfaction between the type of visit (p-value = 0.9117) and among the top four diagnosis (p-value = 0.3371)","PeriodicalId":73862,"journal":{"name":"Journal of neurology research, reviews & reports","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45834249","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-12-31DOI: 10.47363/jnrrr/2021(3)147
Ven Sumedh Thero, Kataria Hb, Aditya Suman
In general it has been observed that the Preparedness levels against the corona virus disease 2019 (COVID-19) pandemic were relatively poor in South Asian countries. However, South Asian countries have lower mortality levels compared with other world countries. COVID-19 has revealed the vulnerabilities of the health system as a whole. In addition, the high burden of non-communicable diseases in South Asia multiplies the complexities in combating present and future health crises. The advantage offered by the younger population demographics in South Asia may not be sustained with the rising burden of noncommunicable diseases and lack of priority setting for improving health systems. Thus the COVID-19 pandemic has provided a window for introspection, scaling up preparedness for future pandemics, and improving the health of the population overall. The COVID pandemic arrived in South Asia at a much later stage compared with other countries. As such, the South Asian countries may have been able to learn from countries that had early peaks, and therefore achieved better preparation in terms of the public health response. For example, this could have resulted in a lower viral load due to more people wearing masks. South Asian countries lift lockdowns despite rising case numbers. Healthcare facilities and hospitals are stretched due to the increase in the number of cases. It has been reported that testing levels in Pakistan and Bangladesh have fallen dramatically. Social distance is much prevalent in sangha members of Buddhism and caste system in Hindu and its associated communities. That help much to such communities during COVID-19 pandemic. Further requires strong leadership and great political will to allocate substantial resources to prepare for future pandemics. The region needs to scale up the existing social ‘safety nets’ rapidly, such as cash transfers for food. South Asian countries have also resorted to the use of online portals, social media, working from home, online learning, direct benefit transfers, delivery of health services through ‘virtual doctors’, deploying facial recognition, and use of thermal scanners for identification of infected people. Delayed vaccine campaigns in Japan, South Korea, and Taiwan have brought more negative attention to their governments as other developed countries surge ahead. Since a huge extent of PM 2.5 can be credited to traffic vehicle’s gas and mechanical consuming of fills, this over all decrease of AQI information by implication shows an impact of lockdown in these nations. Urgent advanced training of both mental and physical health by way of yoga and meditation require
{"title":"Impact of Post Pandemic on Environmental World Disorder","authors":"Ven Sumedh Thero, Kataria Hb, Aditya Suman","doi":"10.47363/jnrrr/2021(3)147","DOIUrl":"https://doi.org/10.47363/jnrrr/2021(3)147","url":null,"abstract":"In general it has been observed that the Preparedness levels against the corona virus disease 2019 (COVID-19) pandemic were relatively poor in South Asian countries. However, South Asian countries have lower mortality levels compared with other world countries. COVID-19 has revealed the vulnerabilities of the health system as a whole. In addition, the high burden of non-communicable diseases in South Asia multiplies the complexities in combating present and future health crises. The advantage offered by the younger population demographics in South Asia may not be sustained with the rising burden of noncommunicable diseases and lack of priority setting for improving health systems. Thus the COVID-19 pandemic has provided a window for introspection, scaling up preparedness for future pandemics, and improving the health of the population overall. The COVID pandemic arrived in South Asia at a much later stage compared with other countries. As such, the South Asian countries may have been able to learn from countries that had early peaks, and therefore achieved better preparation in terms of the public health response. For example, this could have resulted in a lower viral load due to more people wearing masks. South Asian countries lift lockdowns despite rising case numbers. Healthcare facilities and hospitals are stretched due to the increase in the number of cases. It has been reported that testing levels in Pakistan and Bangladesh have fallen dramatically. Social distance is much prevalent in sangha members of Buddhism and caste system in Hindu and its associated communities. That help much to such communities during COVID-19 pandemic. Further requires strong leadership and great political will to allocate substantial resources to prepare for future pandemics. The region needs to scale up the existing social ‘safety nets’ rapidly, such as cash transfers for food. South Asian countries have also resorted to the use of online portals, social media, working from home, online learning, direct benefit transfers, delivery of health services through ‘virtual doctors’, deploying facial recognition, and use of thermal scanners for identification of infected people. Delayed vaccine campaigns in Japan, South Korea, and Taiwan have brought more negative attention to their governments as other developed countries surge ahead. Since a huge extent of PM 2.5 can be credited to traffic vehicle’s gas and mechanical consuming of fills, this over all decrease of AQI information by implication shows an impact of lockdown in these nations. Urgent advanced training of both mental and physical health by way of yoga and meditation require","PeriodicalId":73862,"journal":{"name":"Journal of neurology research, reviews & reports","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47979896","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-09-30DOI: 10.47363/jnrrr/2021(3)142
M. Rahman, Nabidur Rahman, Umme Habiba, Md. Salman Shakil, S. Hossain
As the number of aged people is increasing globally, so is the case of neurodegenerative disease Alzheimer’s disease (AD). Though different treatment strategy have been applied against AD, success rate is meager. Thus, search for natural compounds capable of withstanding AD progression has received momentum. Present article evaluates the potentiality of chitin and chitosan, the natural bio-polymers, in ameliorating AD. Information presented here would be of immense importance to the AD patients, patients’ care givers, health care providers, researchers and policy makers round the world
{"title":"Search for Natural Compounds - Based Therapeutic Approach against Alzheimer’s disease: Chitin and Chitosan – The Choice","authors":"M. Rahman, Nabidur Rahman, Umme Habiba, Md. Salman Shakil, S. Hossain","doi":"10.47363/jnrrr/2021(3)142","DOIUrl":"https://doi.org/10.47363/jnrrr/2021(3)142","url":null,"abstract":"As the number of aged people is increasing globally, so is the case of neurodegenerative disease Alzheimer’s disease (AD). Though different treatment strategy have been applied against AD, success rate is meager. Thus, search for natural compounds capable of withstanding AD progression has received momentum. Present article evaluates the potentiality of chitin and chitosan, the natural bio-polymers, in ameliorating AD. Information presented here would be of immense importance to the AD patients, patients’ care givers, health care providers, researchers and policy makers round the world","PeriodicalId":73862,"journal":{"name":"Journal of neurology research, reviews & reports","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42071655","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-09-30DOI: 10.47363/jnrrr/2021(3)145
F. Mattioli, C. Stampatori, Alice Belleri, M. Pignoli
Purpose: Transcranial magnetic stimulation (TMS) is a noninvasive brain stimulation technique with the potential to improve memory. Mild cognitive impairment (MCI), which still lacks a specific therapy, is a clinical syndrome associated with increased risk of dementia. This study aims to assess the effects of deep TMS (dTMS) on a group of 10 patients diagnosed with amnesic MCI. Methods: We compared the effects of TMS COG treatment (dTMS delivered with H7 helmet for ten daily sessions together with cognitive training of memory and attention), with those of COG treatment (cognitive training alone) of the same duration. Results: Neuropsychological evaluation at baseline, after TMS COG treatment, after COG treatment and at six months follow up, compared with ANOVA, revealed a significant group-by-time interaction (𝑝 = 0.05), favoring the TMS COG treatment for memory tests. The improvement was kept after six months. Other neuropsychological tests were not significantly affected by treatment. Conclusions: These findings suggest that dTMS might be effective as a therapy for MCI and probably a tool to delay cognitive deterioration.
{"title":"Efficacy of TMS and Cognitive Training in Mild Cognitive Impairment: A Pilot Study","authors":"F. Mattioli, C. Stampatori, Alice Belleri, M. Pignoli","doi":"10.47363/jnrrr/2021(3)145","DOIUrl":"https://doi.org/10.47363/jnrrr/2021(3)145","url":null,"abstract":"Purpose: Transcranial magnetic stimulation (TMS) is a noninvasive brain stimulation technique with the potential to improve memory. Mild cognitive impairment (MCI), which still lacks a specific therapy, is a clinical syndrome associated with increased risk of dementia. This study aims to assess the effects of deep TMS (dTMS) on a group of 10 patients diagnosed with amnesic MCI. Methods: We compared the effects of TMS COG treatment (dTMS delivered with H7 helmet for ten daily sessions together with cognitive training of memory and attention), with those of COG treatment (cognitive training alone) of the same duration. Results: Neuropsychological evaluation at baseline, after TMS COG treatment, after COG treatment and at six months follow up, compared with ANOVA, revealed a significant group-by-time interaction (𝑝 = 0.05), favoring the TMS COG treatment for memory tests. The improvement was kept after six months. Other neuropsychological tests were not significantly affected by treatment. Conclusions: These findings suggest that dTMS might be effective as a therapy for MCI and probably a tool to delay cognitive deterioration.","PeriodicalId":73862,"journal":{"name":"Journal of neurology research, reviews & reports","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41345606","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-09-30DOI: 10.47363/jnrrr/2021(3)143
A. Tsolaki, T. Tegos, Ioannis-Nikolaos Chalkias, Efthymios Chalkias, Panagiotis Ageladarakis, T. Papathomas
Neuro-ophthalmogical complications are rare but can be serious after regional block. We present a case of a 54-year-old diabetic patient who was scheduled for pars plana vitrectomy of his right eye due to tractional retinal detachment, under a peribulbar block with a mixture of lidocaine and ropivacaine. He presented with tachycardia, hypertension, seizures, respiratory distress and apnea. He was intubated for less than 24 hours. He was discharged with no neurological deficit. A review regarding these rare but serious neurological complications of ophthalmic surgery is presented, to raise awareness of neurologists, who are called to evaluate and treat these patients
{"title":"Neuro-Ophthalmological Emergencies. Are They Always Innocent? A Case Report and a Literature Review","authors":"A. Tsolaki, T. Tegos, Ioannis-Nikolaos Chalkias, Efthymios Chalkias, Panagiotis Ageladarakis, T. Papathomas","doi":"10.47363/jnrrr/2021(3)143","DOIUrl":"https://doi.org/10.47363/jnrrr/2021(3)143","url":null,"abstract":"Neuro-ophthalmogical complications are rare but can be serious after regional block. We present a case of a 54-year-old diabetic patient who was scheduled for pars plana vitrectomy of his right eye due to tractional retinal detachment, under a peribulbar block with a mixture of lidocaine and ropivacaine. He presented with tachycardia, hypertension, seizures, respiratory distress and apnea. He was intubated for less than 24 hours. He was discharged with no neurological deficit. A review regarding these rare but serious neurological complications of ophthalmic surgery is presented, to raise awareness of neurologists, who are called to evaluate and treat these patients","PeriodicalId":73862,"journal":{"name":"Journal of neurology research, reviews & reports","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44307863","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-09-30DOI: 10.47363/jnrrr/2021(3)144
Ven Sumedh Thero, Kataria Hb, Aditya Suman
Whether chasing down dinner, pushing a stroller up a hill or running errands for a neighbor, we can take joy in the effort. And the more physically active you are, the more rewarding these experiences become. One of the ways that regular exercise changes your brain is by increasing the density of binding sites for endocannabinoids. Spring-like leg behavior is a general feature of mammalian bouncing gaits, such as running and hopping. Although increases in step frequency at a given running speed are known to increase the stiffness of the leg spring (kleg) in non-amputees, little is known about stiffness regulation in unilateral transfemoral amputees. Thus Consequently, the unilateral transfemoral amputees attained the desired step frequency in the unaffected limb, but were unable to match the three highest step frequencies using their affected limbs
{"title":"How Running Give Us a High Expectations to Overcome Neurological Disorders","authors":"Ven Sumedh Thero, Kataria Hb, Aditya Suman","doi":"10.47363/jnrrr/2021(3)144","DOIUrl":"https://doi.org/10.47363/jnrrr/2021(3)144","url":null,"abstract":"Whether chasing down dinner, pushing a stroller up a hill or running errands for a neighbor, we can take joy in the effort. And the more physically active you are, the more rewarding these experiences become. One of the ways that regular exercise changes your brain is by increasing the density of binding sites for endocannabinoids. Spring-like leg behavior is a general feature of mammalian bouncing gaits, such as running and hopping. Although increases in step frequency at a given running speed are known to increase the stiffness of the leg spring (kleg) in non-amputees, little is known about stiffness regulation in unilateral transfemoral amputees. Thus Consequently, the unilateral transfemoral amputees attained the desired step frequency in the unaffected limb, but were unable to match the three highest step frequencies using their affected limbs","PeriodicalId":73862,"journal":{"name":"Journal of neurology research, reviews & reports","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44906270","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-06-30DOI: 10.47363/jnrrr/2021(3)140
R. Koreen, J. Do
Guillain Barre Syndrome (GBS) is a rare neurologic disorder in which the immune system mistakenly attacks the peripheral nervous system due to molecular mimicry. GBS symptoms can range from a mild episode of weakness to devastating paralysis and respiratory failure. The exact cause of GBS is unknown, but it is often thought to be due to a preceding viral infection or rarely due to vaccination. To date, there has only been one reported case of Guillain Barre Syndrome associated with the administration of Ad26.COV2.S vaccine (Janssen/Johnson & Johnson COVID-19 vaccine) [3]. Here, we describe the case of a 59-year-old woman who received the Johnson & Johnson COVID-19 vaccine and subsequently developed symptoms consistent with GBS. Unfortunately, due to failure to obtain lumbar puncture (LP) and electromyography (EMG), it is only possible to diagnose Guillain Barre syndrome with Level 3 diagnostic certainty using the Brighton criteria [6]. We are of the opinion that our patient developed GBS subsequent to the vaccination, but not necessarily consequent to the vaccination, as it remains possible that she may have contracted an asymptomatic infection prior to inoculation
格林-巴利综合征(GBS)是一种罕见的神经系统疾病，由于分子模仿，免疫系统错误地攻击周围神经系统。GBS的症状可以从轻微的虚弱发作到毁灭性的瘫痪和呼吸衰竭。GBS的确切病因尚不清楚，但通常认为是由于先前的病毒感染，很少是由于接种疫苗。迄今为止，仅报告了一例与Ad26.COV2治疗相关的格林-巴利综合征病例。S疫苗(Janssen/Johnson & Johnson COVID-19疫苗)在这里，我们描述了一名59岁女性的病例，她接种了强生COVID-19疫苗，随后出现了与GBS一致的症状。不幸的是，由于未能获得腰椎穿刺(LP)和肌电图(EMG)，只能使用布莱顿标准[6]诊断格林-巴利综合征，诊断确定性为3级。我们认为，我们的患者在接种疫苗后出现了GBS，但不一定是接种疫苗的结果，因为她可能在接种前感染了无症状感染
{"title":"The Development of Guillain Barre Syndrome Subsequent to Administration of Ad26.COV2.S Vaccine","authors":"R. Koreen, J. Do","doi":"10.47363/jnrrr/2021(3)140","DOIUrl":"https://doi.org/10.47363/jnrrr/2021(3)140","url":null,"abstract":"Guillain Barre Syndrome (GBS) is a rare neurologic disorder in which the immune system mistakenly attacks the peripheral nervous system due to molecular mimicry. GBS symptoms can range from a mild episode of weakness to devastating paralysis and respiratory failure. The exact cause of GBS is unknown, but it is often thought to be due to a preceding viral infection or rarely due to vaccination. To date, there has only been one reported case of Guillain Barre Syndrome associated with the administration of Ad26.COV2.S vaccine (Janssen/Johnson & Johnson COVID-19 vaccine) [3]. Here, we describe the case of a 59-year-old woman who received the Johnson & Johnson COVID-19 vaccine and subsequently developed symptoms consistent with GBS. Unfortunately, due to failure to obtain lumbar puncture (LP) and electromyography (EMG), it is only possible to diagnose Guillain Barre syndrome with Level 3 diagnostic certainty using the Brighton criteria [6]. We are of the opinion that our patient developed GBS subsequent to the vaccination, but not necessarily consequent to the vaccination, as it remains possible that she may have contracted an asymptomatic infection prior to inoculation","PeriodicalId":73862,"journal":{"name":"Journal of neurology research, reviews & reports","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43436255","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-06-30DOI: 10.47363/jnrrr/2021(3)138
M. Altieri, M. Fratino, F. Pauri, A. Conte, M. Frontoni, Chiara Merluzzo, S. Crisafulli, V. Piero
Background: Italy was one of the first affected countries by coronavirus disease 2019 (COVID-19) pandemic. Public health measures like quarantine or national lockdown were adopted, with negative psychological and clinical effects on patients with chronic diseases. To investigate the impact of lockdown on patients with multiple sclerosis (MS), we developed a 36 items self-report questionnaire. Methods: Questionnaires were emailed to 120 patients with MS and 100 with chronic migraine (CM) as a control group, matched for age, sex, and education. The questionnaire was divided into five domains, evaluating concerns about 1) MS and therapy during COVID-19 pandemic, 2) personal and family caregiving, 3) working activities, 4) general and disease-related emotions during the lockdown, 5) future expectations concerning health status, social life, and working activity. Results: patients with MS had higher scores than those with CM in domains 4 and 5, investigating respectively general and disease-related emotions and future expectations (p= 0.05 and 0.02 respectively). About half of the patients with MS expressed some concern about the need to continue their therapy during the pandemic compared to people with CM (p= 0.0002). Conclusions: Covid-19 pandemic had a more negative impact on psychological status of patients with MS compared with those with CM
{"title":"Effect of COVID-19 Lockdown on Patients with Multiple Sclerosis: an Italian Survey","authors":"M. Altieri, M. Fratino, F. Pauri, A. Conte, M. Frontoni, Chiara Merluzzo, S. Crisafulli, V. Piero","doi":"10.47363/jnrrr/2021(3)138","DOIUrl":"https://doi.org/10.47363/jnrrr/2021(3)138","url":null,"abstract":"Background: Italy was one of the first affected countries by coronavirus disease 2019 (COVID-19) pandemic. Public health measures like quarantine or national lockdown were adopted, with negative psychological and clinical effects on patients with chronic diseases. To investigate the impact of lockdown on patients with multiple sclerosis (MS), we developed a 36 items self-report questionnaire. Methods: Questionnaires were emailed to 120 patients with MS and 100 with chronic migraine (CM) as a control group, matched for age, sex, and education. The questionnaire was divided into five domains, evaluating concerns about 1) MS and therapy during COVID-19 pandemic, 2) personal and family caregiving, 3) working activities, 4) general and disease-related emotions during the lockdown, 5) future expectations concerning health status, social life, and working activity. Results: patients with MS had higher scores than those with CM in domains 4 and 5, investigating respectively general and disease-related emotions and future expectations (p= 0.05 and 0.02 respectively). About half of the patients with MS expressed some concern about the need to continue their therapy during the pandemic compared to people with CM (p= 0.0002). Conclusions: Covid-19 pandemic had a more negative impact on psychological status of patients with MS compared with those with CM","PeriodicalId":73862,"journal":{"name":"Journal of neurology research, reviews & reports","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42769695","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-06-30DOI: 10.47363/jnrrr/2021(3)139
R. Gomes
Sheehan’s syndrome (SS) or necrosis of pituitary gland is a rare complication of severe postpartum hemorrhage. It may cause hypopituitarism immediately or several years later, depending on the degree of tissue destruction. Sheehan’s syndrome though rare is still one of the commonest causes of hypopituitarism in developing countries like ours. The presence of an intercurrent infection and administration of thyroxine exacerbated her corticosteroid insufficiency. Intracranial hypertension (IH) manifested as bilateral optic disc swelling with reduced visual acuity, bilateral sixth nerve palsies, and impaired consciousness. Intracranial hypertension (IH) has been associated with hypocortisolism caused by either primary adrenocortical insufficiency or corticosteroid withdrawal. The author describes a case of a young lady with IH with acute SS who presented on 3rd day postpartum after lower uterine cesarean section with acute severe symptomatic hyponatremia which was complicated by postpartum hemorrhage. The clinical manifestations of IH resolved with corticosteroid replacement
{"title":"Co-presentation of Acute Sheehan Syndrome with Raised Intracranial Pressure in a Post-partum Lady","authors":"R. Gomes","doi":"10.47363/jnrrr/2021(3)139","DOIUrl":"https://doi.org/10.47363/jnrrr/2021(3)139","url":null,"abstract":"Sheehan’s syndrome (SS) or necrosis of pituitary gland is a rare complication of severe postpartum hemorrhage. It may cause hypopituitarism immediately or several years later, depending on the degree of tissue destruction. Sheehan’s syndrome though rare is still one of the commonest causes of hypopituitarism in developing countries like ours. The presence of an intercurrent infection and administration of thyroxine exacerbated her corticosteroid insufficiency. Intracranial hypertension (IH) manifested as bilateral optic disc swelling with reduced visual acuity, bilateral sixth nerve palsies, and impaired consciousness. Intracranial hypertension (IH) has been associated with hypocortisolism caused by either primary adrenocortical insufficiency or corticosteroid withdrawal. The author describes a case of a young lady with IH with acute SS who presented on 3rd day postpartum after lower uterine cesarean section with acute severe symptomatic hyponatremia which was complicated by postpartum hemorrhage. The clinical manifestations of IH resolved with corticosteroid replacement","PeriodicalId":73862,"journal":{"name":"Journal of neurology research, reviews & reports","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43819458","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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