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Energizing Healing with Electromagnetic Field Therapy in Musculoskeletal Disorders. 用电磁场疗法治疗肌肉骨骼疾病。
Pub Date : 2024-01-01 Epub Date: 2024-05-17 DOI: 10.26502/josm.511500147
Resmi Rajalekshmi, Devendra K Agrawal

There is mounting evidence to suggest that exogenous electromagnetic fields (EMF) may play a significant role in various biological processes that are crucial to therapeutic interventions. EMFs have been identified as a non-invasive, safe, and effective therapy that appears to have no apparent side effects. Numerous studies have demonstrated that pulsed EMFs (PEMFs) have the potential to become a stand-alone or adjunctive treatment modality for managing musculoskeletal disorders. However, several questions remain unresolved. Before their widespread clinical application, further research from well-designed, high-quality studies is required to standardize treatment parameters and determine the optimal protocol for healthcare decision-making. This article provides a comprehensive overview of the impact of musculoskeletal diseases on overall well-being, the limitations of conventional treatments, and the need to explore alternative therapeutic modalities such as electromagnetic field (EMF) therapy. EMF therapy uses low-frequency electromagnetic waves to stimulate tissue repair, reduce inflammation, and modulate pain signals, making it a safe and convenient alternative to conventional treatments. The article also discusses the historical perspective of EMF therapy in medicine. The article highlights the potential of EMF therapy as a personalized and comprehensive care option for musculoskeletal diseases, either alone or in conjunction with other therapies. It emphasizes the imperative for further research in this field and presents a compelling case for the use of EMF therapy in managing musculoskeletal diseases. Overall, the available findings on the underlying cellular and molecular biology support the use of EMF therapy as a viable option for the management of musculoskeletal disorders and stresses the need for continued research in this area.

越来越多的证据表明,外源电磁场(EMF)可能在对治疗干预至关重要的各种生物过程中发挥重要作用。电磁场已被确定为一种非侵入性、安全、有效的疗法,似乎没有明显的副作用。大量研究表明,脉冲电磁场(PEMFs)有可能成为治疗肌肉骨骼疾病的一种独立或辅助治疗方式。然而,仍有几个问题尚未解决。在其广泛应用于临床之前,需要对设计良好的高质量研究进行进一步研究,以规范治疗参数,并为医疗决策确定最佳方案。本文全面概述了肌肉骨骼疾病对整体健康的影响、传统疗法的局限性以及探索电磁场疗法等替代治疗方式的必要性。电磁场疗法使用低频电磁波来刺激组织修复、减轻炎症和调节疼痛信号,是一种安全、方便的传统疗法替代方法。文章还从历史角度探讨了电磁场疗法在医学中的应用。文章强调了电磁场疗法作为治疗肌肉骨骼疾病的个性化综合疗法的潜力,既可单独使用,也可与其他疗法结合使用。文章强调了在这一领域开展进一步研究的必要性,并提出了使用电磁场疗法治疗肌肉骨骼疾病的令人信服的理由。总之,关于基本细胞和分子生物学的现有研究结果支持将电磁场疗法作为治疗肌肉骨骼疾病的一种可行选择,并强调了在这一领域继续开展研究的必要性。
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引用次数: 0
Chronic Adaptation of Achilles Tendon Tissues upon Injury to Rotator Cuff Tendon in Hyperlipidemic Swine. 高脂血症猪跟腱组织在肩袖肌腱损伤后的慢性适应。
Pub Date : 2024-01-01 Epub Date: 2024-05-10 DOI: 10.26502/josm.511500146
Merlin Rajesh Lal, Devendra K Agrawal

The biomechanical properties of the tendon are affected due to the changes in composition of the tendon extracellular matrix (ECM). Age, overuse, trauma and metabolic disorders are a few associated conditions that contribute to tendon abnormalities. Hyperlipidemia is one of the leading factors that contribute to the compromised biomechanical. Injury was made on infraspinatus tendon of hyperlipidemic swines. After 8 weeks (i) infraspinatus tendon from the injury site, (ii) infraspinatus tendon from the contralateral side and (iii) Achilles tendon, were collected and analyzed for ECM components that form the major part in biomechanical properties. Immunostaining of infraspinatus tendon on the injury site had higher staining collagen type-1 (COL1A1), biglycan, prolyl 4-hydroxylase and mohawk but lower staining for decorin than the control group. The Achilles tendon of the swines that had injury on infraspinatus tendon showed a chronic adaptation towards load which was evident from a more organized ECM with increased decorin, mohawk and decreased biglycan, scleraxis. The mechanism behind the collagen turnover and chronic adaptation to load need to be studied in detail with the biomechanical properties.

肌腱细胞外基质(ECM)成分的变化会影响肌腱的生物力学特性。年龄、过度使用、创伤和代谢紊乱是导致肌腱异常的几种相关病症。高脂血症是导致生物力学受损的主要因素之一。对高脂血症猪的冈下肌腱进行了损伤。8 周后,收集(i) 受伤部位的冈下肌腱、(ii) 对侧的冈下肌腱和 (iii) 跟腱,并对构成生物力学特性主要部分的 ECM 成分进行分析。与对照组相比,受伤部位冈下肌腱的免疫染色较高,包括 1 型胶原蛋白(COL1A1)、biglycan、脯氨酰 4-羟化酶和莫霍克,但装饰素的染色较低。冈下肌腱受伤的猪的跟腱显示出对负荷的慢性适应,这从更有组织的 ECM(decorin、mohawk 增加,biglycan、scleraxis 减少)中可见一斑。胶原更替和对负荷的慢性适应背后的机制需要结合生物力学特性进行详细研究。
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引用次数: 0
Hyperlipidemia Induced Pathological Changes with no Effect in Biomechanical Properties in the Achilles Tendon of Young Swine. 高脂血症诱发病理变化,但对幼猪跟腱的生物力学特性没有影响
Pub Date : 2024-01-01 Epub Date: 2024-04-22 DOI: 10.26502/josm.511500144
Merlin Rajesh Lal L P, Devendra K Agrawal

Hyperlipidemia is linked to atherosclerosis and various diseases. Its strong association with Achilles tendinopathies and xanthomas affects tendon properties through lipid deposition in tendon tissue. We examined the impact of hyperlipidemia on the biomechanical properties of the swine Achilles tendons. Swines were fed a high-cholesterol-high-fat diet to induce hyperlipidemia, and their Achilles tendons were collected and examined for biomechanical properties. The ultimate tensile strength, modulus of elasticity and viscoelastic properties did not exhibit significant differences between hyperlipidemic and control swines. H&E and pentachrome staining revealed extracellular matrix (ECM) disorganization and cellular infiltration in the hyperlipidemic swines, highlighting a marked difference between the control and hyperlipidemic groups. These results suggest hyperlipidemia in young swines alters the tendon composition and may contribute to weak biomechanical properties with time.

高脂血症与动脉粥样硬化和各种疾病有关。高脂血症与跟腱病和黄瘤密切相关,会通过脂质在肌腱组织中的沉积影响肌腱的特性。我们研究了高脂血症对猪跟腱生物力学特性的影响。给猪喂食高胆固醇-高脂肪饮食以诱发高脂血症,收集猪的跟腱并检测其生物力学特性。高脂血症猪和对照组猪的极限拉伸强度、弹性模量和粘弹性能没有明显差异。H&E 和五色染色显示,高脂血症猪的细胞外基质(ECM)发生了紊乱和细胞浸润,对照组和高脂血症组之间存在明显差异。这些结果表明,幼年猪的高脂血症会改变肌腱的组成,并可能随着时间的推移导致生物力学特性减弱。
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引用次数: 0
Whole Body Cryotherapy in Sport and Physical Activity: A Narrative Review 运动和身体活动中的全身冷冻疗法:述评
Pub Date : 2023-01-01 DOI: 10.26502/josm.511500102
Paolo Mario Sarais, G. Alvarez Rey, G. Boni, D. Dıraçoğlu, J. Laíns, Raimondo Leone, F. Migliore, A. Perrotta, A. Migliore
Cold therapy application is commonly used to relieve pain symptoms, to reduce inflammation in chronic diseases and damage in injuries at the musculoskeletal level. Two types of technologies, Partial Body Cryotherapy (PBC) or Whole Body Cryotherapy (WBC), are available in the market. This narrative review reports data from trials exploring WBC in Sport and in physical activity with the aim to show limitations and effectiveness in healthy subjects performing sport activity. The systematic search was conducted on the past ten years. The search keywords were "Whole Body Cryotherapy" OR "Cryogenic chamber therapy" OR "Cryostimulation" AND "Sport" OR "Exercise" OR "Athlete" OR "Physical Activity." The sample size, subject’s age and gender, year of publication, duration and temperature of exposition, physical activity and outcomes were extracted. 15 articles met the inclusion criteria. Data on 265 subjects aged between 20 to 56 years were reported. The WBC protocols covered temperatures from -20 to -120 degrees Celsius. Exposure times ranged from 1 minute to 3 minutes. The cryostimulation sessions were coupled to normal daily recreational activities or, in the case of athletes, competitive activities during the competition season. WBC is a safe procedure and no major adverse events neither alteration of vital parameters were reported. The benefits have been found especially in post-exercise DOMS. Since many aspects need to be clarified a research agenda has been produced to answer crucial questions. In conclusion WBC seems to be a useful tool in Sport Medicine. However, further studies are necessary to establish standardized protocols.
冷疗法通常用于缓解疼痛症状,减少慢性疾病的炎症和肌肉骨骼损伤。市场上有两种技术,部分身体冷冻疗法(PBC)或全身冷冻疗法(WBC)。这篇叙述性综述报告了研究运动和体育活动中白细胞的试验数据,目的是显示在进行体育活动的健康受试者中的局限性和有效性。对过去十年进行了系统的调查。搜索关键词是“全身冷冻疗法”或“低温室疗法”或“冷冻刺激”和“运动”或“锻炼”或“运动员”或“体育活动”。提取样本量、受试者的年龄和性别、出版年份、展示时间和温度、体力活动和结果。15篇文章符合纳入标准。报告了265名年龄在20至56岁之间的受试者的数据。WBC方案涵盖了-20至-120摄氏度的温度。曝光时间从1分钟到3分钟不等。冷冻刺激与正常的日常娱乐活动相结合,或者在运动员的情况下,在比赛季节进行竞技活动。白细胞计数是一个安全的过程,没有重大的不良事件,也没有重要参数的改变的报道。运动后迟发性迟发性肌肉酸痛的益处尤其明显。由于许多方面需要澄清,因此制定了一个研究议程来回答关键问题。总之,白细胞计数在运动医学中似乎是一个有用的工具。然而,需要进一步的研究来建立标准化的方案。
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引用次数: 0
Sensitivity of Diagnostic Methods for Detecting S. stercoralis Infection and Comparison of the Total Global Number of Strongyloidiasis Cases with Other Recognized NTDs: A Systematic Review 检测粪链球菌感染的诊断方法的敏感性以及全球棒状线虫病病例总数与其他公认的被忽视热带病的比较:系统综述
Pub Date : 2023-01-01 DOI: 10.26502/josm.511500098
Heron Gezahegn
,
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引用次数: 0
Creating an Inexpensive PVC Knee Model for the Training of Ultrasound-Guided Medial Intra-Articular Knee Injections 制造一种廉价的PVC膝关节模型用于超声引导下内侧关节内膝关节注射训练
Pub Date : 2023-01-01 DOI: 10.26502/josm.511500104
Ryland McDermott, Joshua Melanson, Skylar Davidson, Nora Doyle
,
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引用次数: 0
Impact of Erroneous Belief on Timely Health Care-Seeking Practices Among Noma (Facial Gangrene) Survivors in Ethiopia 在埃塞俄比亚的Noma(面部坏疽)幸存者中,错误信念对及时寻求医疗保健的影响
Pub Date : 2023-01-01 DOI: 10.26502/josm.511500105
Heron Gezahegn Gebretsadik
Background: Noma is a gangrenous disease that primarily affects young children in extremely poor regions of Africa, Asia, and Latin America. Noma has one of the highest mortality rates, estimated at 90%. Noma begins in the oral cavity and it spreads rapidly and destroys bone, muscle, and skin in the orofacial anatomy. The full onset of Noma is preventable and inexpensive to treat at its early stage. However, a significant number of Noma cases do not receive treatment until it is either too late to save their face or, more commonly, their life. With the recommendation to further investigate the beliefs and perceptions of Noma patients to understand their behavior in seeking medical care, the focus in this situation should remain on understanding the underlying causes. This study examined the main reasons Noma survivors initially had for delaying medical care and that eventually motivated them to seek it. Methods: To achieve the objective of the study, a structured and scheduled qualitative interview was used. A total of 46 Noma cases from different geographic areas in Ethiopia were interviewed in March 2023 to describe the main factors that prevent them from seeking timely medical care and ultimately lead them to seek it. The study participants were asked to indicate their main reason for not seeking medical care soon enough. Then they were asked why they finally decided to pursue medical care.
背景:坏疽性口炎是一种坏疽性疾病,主要影响非洲、亚洲和拉丁美洲极端贫困地区的幼儿。坏疽性口炎是死亡率最高的疾病之一,估计为90%。坏疽性口炎始于口腔,扩散迅速,破坏口腔面部的骨骼、肌肉和皮肤。坏疽性口炎的全面发作是可以预防的,而且在早期阶段治疗费用低廉。然而,相当数量的坏疽性口炎病例没有得到治疗,直到为时已晚,无法挽回他们的颜面,或者更常见的是,无法挽回他们的生命。建议进一步调查坏疽性口炎患者的信念和观念,以了解他们寻求医疗服务的行为,在这种情况下,重点仍应放在了解根本原因上。这项研究调查了Noma幸存者最初推迟医疗护理的主要原因,并最终促使他们寻求医疗护理。方法:为达到本研究的目的,采用了结构化和预定的定性访谈。2023年3月,我们对来自埃塞俄比亚不同地理区域的46例坏疽性口炎病例进行了访谈,以描述阻止他们及时寻求医疗护理并最终导致他们寻求医疗护理的主要因素。研究参与者被要求说明他们没有尽快就医的主要原因。然后,他们被问及为什么最终决定接受医疗护理。
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引用次数: 0
Quantification of Physical Activities Simulated Exercise Therapy in Ambulatory Inpatients Using Surface Electromyogram from the Vastus Medialis 利用股内侧肌表肌电图量化非卧床病人的模拟运动治疗
Pub Date : 2023-01-01 DOI: 10.26502/josm.511500085
T. Tsuji, Chiaki Wada, M. Kawanishi, Yasuhisa Fujita, Y. Kamijo, Y. Umemoto, K. Kouda, Kazunari Nishiyama, F. Tajima, Yukihide Nishimura
The present study aimed to assess whether surface electromyogram (sEMG) signal from the vastus medialis could be a candidate method to quantify physical activities during combined activities in ambulatory persons (ergometer exercise, treadmill walking, and squatting). In the first trial, twelve healthy men performed a graded cycle ergometer exercise at 0%, 30%, 60%, and 80% of peak oxygen consumption rate (VO 2peak ), followed by treadmill walking at 0, 2, 4, and 6 km/h for 3 min of each, and each exercise was intermitted by 3 min of rest. sEMG from the Vastus Medialis Oblique Longus (VML) was collected, and the integrated amplitude of spikes (sEMGAMP) were calculated every minute. Positive correlations were observed between ∆VO 2 and ΣsEMG AMP ; data at sampling frequency of 250Hz in both exercise types were plotted (r=0.888; P<0.0001; y=339.04x+4.0267). In the second trial, thirteen healthy participants (three women) performed the combined exercise comprising 3 min each for optimal walking (3 km/h), fast walking (5 km/h and 6 km/h for women and men, respectively), squatting, second optimal walking, and ergometer exercise at 30% VO 2peak , which were intermitted by 30 sec. Finally, they performed ergometer exercise at 100% VO 2peak for 1 min followed by 3-min cool-down (0W). Changes (∆) in VO 2 from the resting value and sEMG AMP during exercise were summed throughout the exercise period (Σ∆VO 2 and ΣsEMG AMP ). ΣΔsEMG AMP was positively correlated with ΣΔVO 2 (r=0.68, p=0.011, @250Hz). Monitoring sEMG from VML may be a candidate method for the evaluation of physical activities for exercise therapy in ambulatory persons.
本研究旨在评估来自股内侧肌的表面肌电图(sEMG)信号是否可以作为一种候选方法来量化活动者在联合活动(测力仪运动、跑步机行走和下蹲)期间的身体活动。在第一项试验中,12名健康男性在0%、30%、60%和80%的峰值耗氧率(vo2peak)下进行了渐进式循环力计运动,然后在跑步机上以0、2、4和6公里/小时的速度步行3分钟,每次运动中间休息3分钟。收集股内侧斜长肌(VML)的肌电信号,每分钟计算一次综合峰幅(sEMGAMP)。∆VO 2与ΣsEMG AMP呈正相关;绘制采样频率为250Hz时两种运动类型的数据(r=0.888;P < 0.0001;339.04 x + y = 4.0267)。在第二项试验中,13名健康参与者(3名女性)进行了3分钟的组合运动,分别为最佳步行(3公里/小时)、快速步行(女性和男性分别为5公里/小时和6公里/小时)、深蹲、第二最佳步行和30% VO 2峰值的测力仪运动,这些运动间隔30秒。最后,他们以100% VO 2峰值进行了1分钟的测力仪运动,然后进行了3分钟的冷却(0W)。计算运动期间VO 2与静息值和sEMG AMP的变化(∆)(Σ∆VO 2和ΣsEMG AMP)。ΣΔsEMG AMP与ΣΔVO 2呈正相关(r=0.68, p=0.011, @250Hz)。监测VML的肌电图可能是评估运动治疗中运动活动的候选方法。
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引用次数: 0
The Relationship between Antigravity Treadmill Therapy Settings and Gait Cycle Parameters 反重力跑步机治疗设置与步态周期参数之间的关系
Pub Date : 2023-01-01 DOI: 10.26502/josm.511500128
Miloslav Kubicek and, Tomas Brozek
Background: The effective gait restoration due to antigravity treadmill exercise has been demonstrated in patients with locomotor or nervous system disorders. The element of unweighting, its effect on the parameters of the gait cycle and possible deviation from overground walking, despite all the clinical evidence, remains questionable.
背景:反重力跑步机运动对运动或神经系统疾病患者的步态恢复效果已得到证实。尽管有临床证据,但不称重的因素,其对步态周期参数的影响以及可能偏离地面行走的影响仍然值得怀疑。
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引用次数: 0
Beneficial Effects of Physical Activity in Rheumatoid Arthritis Patients: Focus on Active Biomolecules 体育活动对类风湿关节炎患者的有益作用:关注活性生物分子
Pub Date : 2023-01-01 DOI: 10.26502/josm.511500096
R. Restuccia, Giovanni Ficarra, Fulvio Perani, G. Bagnato, Joseph N. Grima, C. Mannucci, A. Bitto, F. Trimarchi, D. Di Mauro
Physical Activity (PA) has a fundamental role in subjects with Rheumatoid Arthritis (RA), in terms of motility, joint function, muscle wasting, BMI (Body Mass Index), Cardiovascular Fitness (CRF), mental health, but also changes in bioactive molecules that might influence the disease activity and patient’s wellbeing. Literature was searched for clinical trials, randomized-controlled trials, and pilot studies published in the last 15 years. Studies using as adjunctive therapy aerobic exercise, HighIntensity Interval Training (HIIT), and moderate training were included. The available papers shown that exercise programs improve joint’s mobility and flexibility and the overall health status, without differences regarding age, gender or disease activity. All these findings are supported by the modulatory role of exercise-induced cytokines as interleukin-6 (IL6) and irisin, together with a reduction of inflammatory markers.
身体活动(PA)在类风湿关节炎(RA)患者的运动,关节功能,肌肉萎缩,BMI(身体质量指数),心血管健康(CRF),心理健康方面具有基本作用,但也可能影响疾病活动和患者健康的生物活性分子的变化。文献检索了近15年来发表的临床试验、随机对照试验和试点研究。将有氧运动、高强度间歇训练(HIIT)和中等强度训练作为辅助治疗纳入研究。现有的论文表明,锻炼计划可以改善关节的活动性和灵活性以及整体健康状况,而不受年龄、性别或疾病活动的影响。所有这些发现都得到了运动诱导的细胞因子如白细胞介素-6 (IL6)和鸢尾素的调节作用以及炎症标志物的减少的支持。
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引用次数: 0
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Journal of orthopaedics and sports medicine
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