Merlin Rajesh Lal L.P, Mohamed M. Radwan, Finosh G. Thankam, Devendra K. Agrawal
Rotator cuff injury is the leading cause of shoulder pain. Hyperlipidemia is responsible in depositing lipids in tendons and reduce the healing upon injuries or tears. In this study, we created rotator cuff injury and repair models in swine and studied the changes in biomechanical properties of infraspinatus tensons in hyperlipidemic swine. The infraspinatus tendons from control group, hyperlipidemic injury and repair group of animals were collected and tested ex-vivo. The ultimate tensile strength (UTS) and modulus of elasticity increased in the tendons from the contralateral side on both the injury and repair models were higher than the injury side. The presence of large number of fibrous tissues in the surgical site of repair and increased water content was observed in addition to the fatty infiltration which would have contributed to the decreased mechanical properties of the inured tendons following repair. Meanwhile the tendons of the contralateral side in both the injury and repair model showed adaptation to chronic load as observed in the modulus and viscoelastic properties. This is a pilot study that warrants detailed investigation in a larger sample size with longer duration following tendon injury and repair to gain better understanding on the effect of hyperlipidemia in the healing of rotator cuff tendon injury.
{"title":"Rotator Cuff Tendon Repair after Injury in Hyperlipidemic Swine Decreases Biomechanical Properties","authors":"Merlin Rajesh Lal L.P, Mohamed M. Radwan, Finosh G. Thankam, Devendra K. Agrawal","doi":"10.26502/josm.511500127","DOIUrl":"https://doi.org/10.26502/josm.511500127","url":null,"abstract":"Rotator cuff injury is the leading cause of shoulder pain. Hyperlipidemia is responsible in depositing lipids in tendons and reduce the healing upon injuries or tears. In this study, we created rotator cuff injury and repair models in swine and studied the changes in biomechanical properties of infraspinatus tensons in hyperlipidemic swine. The infraspinatus tendons from control group, hyperlipidemic injury and repair group of animals were collected and tested ex-vivo. The ultimate tensile strength (UTS) and modulus of elasticity increased in the tendons from the contralateral side on both the injury and repair models were higher than the injury side. The presence of large number of fibrous tissues in the surgical site of repair and increased water content was observed in addition to the fatty infiltration which would have contributed to the decreased mechanical properties of the inured tendons following repair. Meanwhile the tendons of the contralateral side in both the injury and repair model showed adaptation to chronic load as observed in the modulus and viscoelastic properties. This is a pilot study that warrants detailed investigation in a larger sample size with longer duration following tendon injury and repair to gain better understanding on the effect of hyperlipidemia in the healing of rotator cuff tendon injury.","PeriodicalId":73881,"journal":{"name":"Journal of orthopaedics and sports medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134883167","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Akhil Sharma MD, Amanda N Fletcher MD, MS, Jay K Shah DO, MBA, Craig C Akoh MD, Selene G. Parekh MD, MBA
{"title":"The Effect of Thursday Night Football on Injuries in the National Football League","authors":"Akhil Sharma MD, Amanda N Fletcher MD, MS, Jay K Shah DO, MBA, Craig C Akoh MD, Selene G. Parekh MD, MBA","doi":"10.26502/josm.511500115","DOIUrl":"https://doi.org/10.26502/josm.511500115","url":null,"abstract":"","PeriodicalId":73881,"journal":{"name":"Journal of orthopaedics and sports medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69349691","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Zhang Haohua, Wang Jiaying, Zhang Kuan, Yan Songhua
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{"title":"Study on Selecting the Surgical methods for Patients with Knee Osteoarthritis based on BP Neural Network","authors":"Zhang Haohua, Wang Jiaying, Zhang Kuan, Yan Songhua","doi":"10.26502/josm.511500089","DOIUrl":"https://doi.org/10.26502/josm.511500089","url":null,"abstract":",","PeriodicalId":73881,"journal":{"name":"Journal of orthopaedics and sports medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69349740","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Background: Sacroiliac joint dysfunction frequently causes pain in low back. Localized tenderness and pain around the sacroiliac joint are signs. Objective: This study aimed to compare the effectiveness of mulligan mobilization Technique Versus McKenzie exercises among patients with sacroiliac joint Dysfunction. Methodology: Total 58 patients, with sacroiliac joint dysfunction were included who were fulfilled the eligibility criteria. This trial was registered in Iranian registry with ref#NCT05404451 Dated 01-08-2022. This study is assessor blind. We have used the convenient sampling technique and the Lottery Method was used to randomly select. Participants were then divided into the two groups at random. The researcher and participants were not informed of the allocation process. In envelopes, the allocation was concealed. Group A received treatment with mulligan mobilization technique while group B received treatment with McKenzie exercises. Both groups received treatment for four weeks. Using the VAS and the MODI scale, pain and disability were evaluated before and after treatment. Results: It was observed that McKenzie exercises were more effective than Mulligan mobilization techniques at reducing pain, disability, and enhancing sitting, standing, and walking in patients P value was (>0.005). While there was no significant difference has been observed in personal care lifting, sleeping, when comparing both groups P value was (>0.005). Conclusion: The McKenzie exercises are more efficient than Mulligan's Mobilization technique when the two groups are compared (at reducing pain, disability, and enhancing sitting, standing, and walking in patients).
{"title":"Comparison of Mulligan Mobilization Technique versus Mckenzie Exercises among Patient with Sacroilliac Joint Dysfunction: A Randomized Clinical Trial","authors":"Faisal Ghafoor, Zunairah Ahmad, Afia Irfan, A. Munawar, Iqra Sabir, Faseeh Zulqernain","doi":"10.26502/josm.511500093","DOIUrl":"https://doi.org/10.26502/josm.511500093","url":null,"abstract":"Background: Sacroiliac joint dysfunction frequently causes pain in low back. Localized tenderness and pain around the sacroiliac joint are signs. Objective: This study aimed to compare the effectiveness of mulligan mobilization Technique Versus McKenzie exercises among patients with sacroiliac joint Dysfunction. Methodology: Total 58 patients, with sacroiliac joint dysfunction were included who were fulfilled the eligibility criteria. This trial was registered in Iranian registry with ref#NCT05404451 Dated 01-08-2022. This study is assessor blind. We have used the convenient sampling technique and the Lottery Method was used to randomly select. Participants were then divided into the two groups at random. The researcher and participants were not informed of the allocation process. In envelopes, the allocation was concealed. Group A received treatment with mulligan mobilization technique while group B received treatment with McKenzie exercises. Both groups received treatment for four weeks. Using the VAS and the MODI scale, pain and disability were evaluated before and after treatment. Results: It was observed that McKenzie exercises were more effective than Mulligan mobilization techniques at reducing pain, disability, and enhancing sitting, standing, and walking in patients P value was (>0.005). While there was no significant difference has been observed in personal care lifting, sleeping, when comparing both groups P value was (>0.005). Conclusion: The McKenzie exercises are more efficient than Mulligan's Mobilization technique when the two groups are compared (at reducing pain, disability, and enhancing sitting, standing, and walking in patients).","PeriodicalId":73881,"journal":{"name":"Journal of orthopaedics and sports medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69349784","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The total joint replacement is recognized as one of the most effective medical arbitrations leading to increased mobility, pain relief, and an overall restored function of the joint. Unfortunately, prosthetic debris accumulates after long-term wear of the implant leading to activation of the innate immune response and periprosthetic osteolysis. Understanding the intricate biological mechanisms underlying the innate immune response to implant debris would support the development of novel pharmacological treatments to prolong the life span of the implant. This article provides a detailed description on the role of the innate immune system in response to implant debris, emphasizing the most recent research and outstanding questions. Furthermore, a critical discussion is presented on the novel pharmacological treatments currently under investigation to prevent implant failure.
{"title":"Innate Immune Response in Orthopedic Implant Failure.","authors":"Rajiv Supra, Devendra K Agrawal","doi":"10.26502/josm.511500073","DOIUrl":"https://doi.org/10.26502/josm.511500073","url":null,"abstract":"<p><p>The total joint replacement is recognized as one of the most effective medical arbitrations leading to increased mobility, pain relief, and an overall restored function of the joint. Unfortunately, prosthetic debris accumulates after long-term wear of the implant leading to activation of the innate immune response and periprosthetic osteolysis. Understanding the intricate biological mechanisms underlying the innate immune response to implant debris would support the development of novel pharmacological treatments to prolong the life span of the implant. This article provides a detailed description on the role of the innate immune system in response to implant debris, emphasizing the most recent research and outstanding questions. Furthermore, a critical discussion is presented on the novel pharmacological treatments currently under investigation to prevent implant failure.</p>","PeriodicalId":73881,"journal":{"name":"Journal of orthopaedics and sports medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9912346/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10708404","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Global Estimate of the Total Number of Human Strongyloidiasis Cases: A Systematic Review","authors":"Heron Gezahegn","doi":"10.26502/josm.511500100","DOIUrl":"https://doi.org/10.26502/josm.511500100","url":null,"abstract":",","PeriodicalId":73881,"journal":{"name":"Journal of orthopaedics and sports medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69349406","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Background: Prolapsed Lumbar Intervertebral Disc (PLID) is one of the most common health problems worldwide, as well as in our country, and is one of the potential causes of temporary disability, morbidity, and reasoning of absence at workplaces. Objective: To find out the outcome of C-arm guided transforaminal and caudal epidural steroid injection for low back pain with radiculopathy due to PLID. Methodology: This was a randomized clinical trial conducted among purposively selected 54 patients with PLID with radiculopathy as per selection criteria, attending the Department of Physical Medicine & Rehabilitation in BSMMU, Dhaka, from March 2020 to February 2021. Patients (N=54) were randomly allocated into two groups; patients in group A (n=26) were treated with C-arm guided transforaminal and caudal epidural steroid injection with conservative treatment, and patients in group B (n=28) were treated with conservative treatment only. All patients were followed up in 1st week, 1st month, and 3rd month. Results: The mean age of the participants in group A and group B were 40.88 (± 8.70) and 43.00 (± 11.54) years, respectively. In group A, 9 (34.6%) were housewives, 4 (15.4%) were manual workers, while in group B, 10 (35.7%) were housewives, and 8 (28.6%) were manual workers. In group A, 21 (80.8%) had three disc involvement, while in group B, 19 (67.9%) had three discs involvement, where L4-5-disc involvement was most common in both groups. There was no significant statistical difference between the groups regarding VAS scores at baseline (p=0.235), 1st week (p=0.164), and 1st month (p=0.125). The VAS score was significantly reduced in group A compared to group B at 3rd month (p=0.001). The ODI score was significantly reduced in group A compared to group B at 1st week (p=0.034), 1st month (p=0.016), and at 3rd month (p=0.001). Conclusion: C-arm guided transforaminal and caudal Epidural Steroid Injection significantly improves pain and functional outcomes of patients with radiculopathy due to PLID. Long-term, large scale and multicenter research studies are required to establish the outcome and effectiveness of this procedure.
{"title":"Outcome of C-arm Guided Epidural Steroid Injections in Patients with Prolapsed Lumbar Intervertebral Disc with Radiculopathy","authors":"Tamjid Ali MD, Moshiur Rahman Khasru, Salek Akm, Alauddin Sikdar, Quazi Tamanna Haque","doi":"10.26502/josm.511500112","DOIUrl":"https://doi.org/10.26502/josm.511500112","url":null,"abstract":"Background: Prolapsed Lumbar Intervertebral Disc (PLID) is one of the most common health problems worldwide, as well as in our country, and is one of the potential causes of temporary disability, morbidity, and reasoning of absence at workplaces. Objective: To find out the outcome of C-arm guided transforaminal and caudal epidural steroid injection for low back pain with radiculopathy due to PLID. Methodology: This was a randomized clinical trial conducted among purposively selected 54 patients with PLID with radiculopathy as per selection criteria, attending the Department of Physical Medicine & Rehabilitation in BSMMU, Dhaka, from March 2020 to February 2021. Patients (N=54) were randomly allocated into two groups; patients in group A (n=26) were treated with C-arm guided transforaminal and caudal epidural steroid injection with conservative treatment, and patients in group B (n=28) were treated with conservative treatment only. All patients were followed up in 1st week, 1st month, and 3rd month. Results: The mean age of the participants in group A and group B were 40.88 (± 8.70) and 43.00 (± 11.54) years, respectively. In group A, 9 (34.6%) were housewives, 4 (15.4%) were manual workers, while in group B, 10 (35.7%) were housewives, and 8 (28.6%) were manual workers. In group A, 21 (80.8%) had three disc involvement, while in group B, 19 (67.9%) had three discs involvement, where L4-5-disc involvement was most common in both groups. There was no significant statistical difference between the groups regarding VAS scores at baseline (p=0.235), 1st week (p=0.164), and 1st month (p=0.125). The VAS score was significantly reduced in group A compared to group B at 3rd month (p=0.001). The ODI score was significantly reduced in group A compared to group B at 1st week (p=0.034), 1st month (p=0.016), and at 3rd month (p=0.001). Conclusion: C-arm guided transforaminal and caudal Epidural Steroid Injection significantly improves pain and functional outcomes of patients with radiculopathy due to PLID. Long-term, large scale and multicenter research studies are required to establish the outcome and effectiveness of this procedure.","PeriodicalId":73881,"journal":{"name":"Journal of orthopaedics and sports medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69349626","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
David A. Kolin, Antonio Madrazo-Ibarra, Hersh Patel1, Arda Dalkir, Amoli Vad, N. Vad, Kaitlin M Carroll, Douglas N Mintz, V. Vad
Context: The presence of subchondral Bone Edema-Like Lesions (BELs) in patients with Knee Osteoarthritis (OA) is associated with increased pain and a faster progression of OA. However, the exact prevalence of BELs is controversial due to contradicting findings reported in previous studies. Aim: To evaluate the prevalence of BELs by Magnetic Resonance Imaging (MRI), in patients with adjacent full-thickness cartilage loss of the knee. Settings and Design: Single center cross-sectional study. Methods: We evaluated 100 consecutive MRI studies of patients with Kellgren and Lawrence grade IV knee osteoarthritis from April 2019 to May 2019. The primary outcome of the study was to evaluate the prevalence of BELs. The secondary outcome was to evaluate the association of BELs with the demographic characteristics of patients including age, sex, body mass index, presence of osteophytes, and previous diagnosis of osteoporosis or osteopenia. Results: All patients had pain at the time of MRI evaluation. The average age was 66.5 ± 10.1 years and the average body mass index was 27.3 ± 5.1 kg/m². A total of 86 patients (86%) had BELs on the evaluated MRI, with both male and female patients being equally affected (P=0.405). No demographic characteristic showed a significant association with the presence of BELs. However, while not statistically significant, male patients, patients with obesity, and patients with osteophytes had an increased risk of having BELs. Conclusion: The majority of patients with symptomatic grade IV knee osteoarthritis have BELs on MRI evaluation. No demographic characteristic was associated with a greater risk of presenting BELs.
{"title":"Prevalence of Bone Edema-like Lesions in Patients with Knee Osteoarthritis","authors":"David A. Kolin, Antonio Madrazo-Ibarra, Hersh Patel1, Arda Dalkir, Amoli Vad, N. Vad, Kaitlin M Carroll, Douglas N Mintz, V. Vad","doi":"10.26502/josm.511500092","DOIUrl":"https://doi.org/10.26502/josm.511500092","url":null,"abstract":"Context: The presence of subchondral Bone Edema-Like Lesions (BELs) in patients with Knee Osteoarthritis (OA) is associated with increased pain and a faster progression of OA. However, the exact prevalence of BELs is controversial due to contradicting findings reported in previous studies. Aim: To evaluate the prevalence of BELs by Magnetic Resonance Imaging (MRI), in patients with adjacent full-thickness cartilage loss of the knee. Settings and Design: Single center cross-sectional study. Methods: We evaluated 100 consecutive MRI studies of patients with Kellgren and Lawrence grade IV knee osteoarthritis from April 2019 to May 2019. The primary outcome of the study was to evaluate the prevalence of BELs. The secondary outcome was to evaluate the association of BELs with the demographic characteristics of patients including age, sex, body mass index, presence of osteophytes, and previous diagnosis of osteoporosis or osteopenia. Results: All patients had pain at the time of MRI evaluation. The average age was 66.5 ± 10.1 years and the average body mass index was 27.3 ± 5.1 kg/m². A total of 86 patients (86%) had BELs on the evaluated MRI, with both male and female patients being equally affected (P=0.405). No demographic characteristic showed a significant association with the presence of BELs. However, while not statistically significant, male patients, patients with obesity, and patients with osteophytes had an increased risk of having BELs. Conclusion: The majority of patients with symptomatic grade IV knee osteoarthritis have BELs on MRI evaluation. No demographic characteristic was associated with a greater risk of presenting BELs.","PeriodicalId":73881,"journal":{"name":"Journal of orthopaedics and sports medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69349781","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-01-09DOI: 10.22541/au.164175447.73916057/v1
P. Galea, K. Joyce, Sarah Galea, F. Loughnane
Critical care provision is fundamental in all developed health systems in which severe disease and injury is managed. This is especially true in major trauma centres and high-acuity establishments, where acutely unstable patients can be admitted at any time, requiring clinical monitoring and interventions appropriate for their burden of illness. This single-centre, prospective service evaluation applied validated scoring systems to a surgical population, sampling and following those considered “high-risk” through to discharge or death, alongside all intensive care unit (ICU) admissions during 2019. Primarily we aimed to quantify the number of patients objectively suitable for Level 2 critical care, conventionally provided in a high-dependency unit (HDU) setting. Secondary outcome measures included ICU readmission rate, in-hospital mortality, and delays to ICU admission and discharge. Of the “high-risk” surgical patients, more than eight per week were found to have peri-operative Portsmouth Physiological and Operative Severity Score for the enUmeration of Mortality and morbidity (P-POSSUM) scores that would advocate critical care admission. Only one individual received scheduled peri-operative critical care. Post-operative mortality in this group was 6.1%, though none of these patients was admitted to ICU prior to death. There were 605 ICU admissions in 2019, with 32.1% of admitted days spent at the equivalent of Level 2 critical care, which could have been administered in a HDU if one was available. The ICU readmission rate was 6.45%. This data demonstrates substantial unmet critical care needs, with patients not uncommonly managed in clinically inappropriate areas for extended periods due to delays accessing ICU. A designated HDU may mitigate clinical risk from this subgroup, reducing morbidity and in-hospital mortality, and this methodology for assessing requirements could be used in other similar institutions.
{"title":"A service evaluation examining the requirement for Level 2 critical care in a major trauma centre","authors":"P. Galea, K. Joyce, Sarah Galea, F. Loughnane","doi":"10.22541/au.164175447.73916057/v1","DOIUrl":"https://doi.org/10.22541/au.164175447.73916057/v1","url":null,"abstract":"Critical care provision is fundamental in all developed health systems\u0000in which severe disease and injury is managed. This is especially true\u0000in major trauma centres and high-acuity establishments, where acutely\u0000unstable patients can be admitted at any time, requiring clinical\u0000monitoring and interventions appropriate for their burden of illness.\u0000This single-centre, prospective service evaluation applied validated\u0000scoring systems to a surgical population, sampling and following those\u0000considered “high-risk” through to discharge or death, alongside all\u0000intensive care unit (ICU) admissions during 2019. Primarily we aimed to\u0000quantify the number of patients objectively suitable for Level 2\u0000critical care, conventionally provided in a high-dependency unit (HDU)\u0000setting. Secondary outcome measures included ICU readmission rate,\u0000in-hospital mortality, and delays to ICU admission and discharge. Of the\u0000“high-risk” surgical patients, more than eight per week were found to\u0000have peri-operative Portsmouth Physiological and Operative Severity\u0000Score for the enUmeration of Mortality and morbidity (P-POSSUM) scores\u0000that would advocate critical care admission. Only one individual\u0000received scheduled peri-operative critical care. Post-operative\u0000mortality in this group was 6.1%, though none of these patients was\u0000admitted to ICU prior to death. There were 605 ICU admissions in 2019,\u0000with 32.1% of admitted days spent at the equivalent of Level 2 critical\u0000care, which could have been administered in a HDU if one was available.\u0000The ICU readmission rate was 6.45%. This data demonstrates substantial\u0000unmet critical care needs, with patients not uncommonly managed in\u0000clinically inappropriate areas for extended periods due to delays\u0000accessing ICU. A designated HDU may mitigate clinical risk from this\u0000subgroup, reducing morbidity and in-hospital mortality, and this\u0000methodology for assessing requirements could be used in other similar\u0000institutions.","PeriodicalId":73881,"journal":{"name":"Journal of orthopaedics and sports medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-01-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45123747","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Purpose: The effect of Actovegin® versus Cortisone was investigated on PMA induced human Peripheral Blood Mononuclear Cells (PBMCs). Methods: PBMCs (1 × 10 cells/ml) from ten blood donors (5 f, 5 m; 45–55 years) were grown in medium and exposed to Actovegin® or Cortisone in the presence or absence of PMA. Supernatants were collected to assess the concentration of cytokines/substances: IL-6, TNF-α, IL-8, IL-1 beta, and IL-10. The Reactive Oxygen Species (ROS) were assessed
{"title":"Effect of Actovegin® Versus Cortisone on PMA‐Induced Inflammation on Human Cells","authors":"F. Reichl, Fangfang Liu, Christof Hogg","doi":"10.26502/josm.511500069","DOIUrl":"https://doi.org/10.26502/josm.511500069","url":null,"abstract":"Purpose: The effect of Actovegin® versus Cortisone was investigated on PMA induced human Peripheral Blood Mononuclear Cells (PBMCs). Methods: PBMCs (1 × 10 cells/ml) from ten blood donors (5 f, 5 m; 45–55 years) were grown in medium and exposed to Actovegin® or Cortisone in the presence or absence of PMA. Supernatants were collected to assess the concentration of cytokines/substances: IL-6, TNF-α, IL-8, IL-1 beta, and IL-10. The Reactive Oxygen Species (ROS) were assessed","PeriodicalId":73881,"journal":{"name":"Journal of orthopaedics and sports medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69349438","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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