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Hyperlipidemia Lowers the Biomechanical Properties of Rotator Cuff Tendon 高脂血症降低肩袖肌腱的生物力学性能
Pub Date : 2023-01-01 DOI: 10.26502/josm.511500126
Merlin Rajesh Lal L. P, Devendra K. Agrawal
Infraspinatus tendon is the most affected tendon of the rotator cuff, being an important posterior component of the shoulder joint. Hyperlipidemia is a predisposing factor in the progression of rotator cuff tears and retear. We studied the effect of hyperlipidemia on the biomechanical properties of rotator cuff tendons. The infraspinatus tendon of the rotator cuff from hyperlipidemic swine were collected and tested for ultimate tensile strength (UTS) and modulus of elasticity. Dynamic mechanical analysis was performed to examine viscoelastic properties. The findings revealed no significant difference in UTS but had significantly lower modulus of elasticity in the infraspinatus tendon of the hyperlipidemic group compared to the control group. Moreover, differences in the dynamic modulus, storage modulus, and loss modulus were not statistically significant between the hyperlipidemic and control swine. There was no difference in water content between the groups but the hyperlipidemic group had fatty infiltration aiding the initial decrease in mechanical properties. These findings suggest an association between fat deposition and early changes in the biomechanical properties of the tendons in the shoulder rotator cuff in hyperlipidemic state.
冈下肌腱是肩袖中受影响最大的肌腱,是肩关节的重要后部组成部分。高脂血症是肩袖撕裂和再撕裂进展的一个易感因素。我们研究了高脂血症对肩袖肌腱生物力学特性的影响。收集高脂血症猪肩袖棘下肌腱,测定其极限抗拉强度和弹性模量。进行动态力学分析以检验粘弹性性能。研究结果显示,与对照组相比,高脂血症组的冈下肌腱的UTS无显著差异,但其弹性模量明显降低。此外,在高脂血症猪和对照猪之间,动态模量、储存模量和损失模量的差异无统计学意义。各组之间的含水量没有差异,但高脂血症组有脂肪浸润,有助于机械性能的初步下降。这些发现提示脂肪沉积与高血脂状态下肩袖肌腱生物力学特性的早期变化之间存在关联。
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引用次数: 1
An Innovative Technique for Anterior Cervical Surgery in Sub-axial Cervical Fracture Dislocation with incomplete spinal cord injury: A Paradigm Shift in Surgical Approach 颈椎前路手术治疗亚轴型颈椎骨折脱位伴不完全性脊髓损伤的创新技术:手术入路的范式转变
Pub Date : 2023-01-01 DOI: 10.26502/josm.511500123
Shah Alam, Sharif Ahmed Jonayed, Sarwar Jahan, Abdullah Al Mamun Choudhury, O Z M Dastagir
Introduction: Cervical spine injury was the most common cause of spinal cord injury worldwide in 2013, accounting for 43.9% to 61.5% of all cases. Prior to injury, the majority of individuals with a cervical spine injury was in their prime years and led an active lifestyle. The aim of the study was to evaluate the safety & efficacy of the proposed innovative technique to reduce all cases of subaxial cervical fracture-dislocation.
引言:2013年全球脊髓损伤最常见的原因是颈椎损伤,占所有病例的43.9% ~ 61.5%。在受伤之前,大多数颈椎损伤患者正值壮年,生活方式积极。该研究的目的是评估所提出的创新技术减少所有颈椎下轴骨折脱位病例的安全性和有效性。
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引用次数: 0
Bilobed Flap for Post-Traumatic Angular Deformity Correction of the Fingers in Children 双叶瓣修复儿童手指外伤后角畸形
Pub Date : 2023-01-01 DOI: 10.26502/josm.511500129
João Pedro Farina Brunelli, Ricardo Kaempf, Diego Falcochio
The Fingertip injuries, usually caused by domestic accidents, such as finger crushing in doors and windows, are very common in childhood. They can cause fractures, nail bed injuries and amputations, as well as combined injuries. Initial management, with correct diagnosis and treatment, is critical for the prevention of complications, whose incidence can reach almost 50% of cases. Severe injuries or inadequate treatment can compromise bone growth, causing deformities and loss of finger alignment, impairing function and skill development in later life.
指尖损伤通常是由家庭事故引起的,例如手指在门窗上被压碎,这在儿童时期很常见。它们会导致骨折、甲床损伤和截肢,以及复合损伤。经过正确诊断和治疗的初始管理对于预防并发症至关重要,其发生率可达到近50%的病例。严重的伤害或治疗不当会影响骨骼生长,造成畸形和手指错位,损害晚年的功能和技能发展。
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引用次数: 0
Immunotherapeutic Strategies in the Management of Osteosarcoma. 骨肉瘤的免疫治疗策略。
Pub Date : 2023-01-01 DOI: 10.26502/josm.511500076
Rajiv Supra, Devendra K Agrawal

Osteosarcoma (OS) is the most common primary malignant bone cancer with a high tendency for metastasis. Although treatment strategies involving surgery and chemotherapy have improved outcomes for patients with OS, the prognosis of recurrent OS is quite unsatisfactory. Primary reasons leading to mortality in OS patients are resistance to currently used therapies and the subsequent lung metastasis. Immunotherapy, however, has been shown to be a promising therapeutic strategy against OS. As research progresses, immunotherapy is gradually becoming irreplaceable. This article provides a critical evaluation of several therapeutic strategies for OS including immunomodulation, vaccine therapy, and immunologic checkpoint blockade.

骨肉瘤是最常见的原发性恶性骨癌,具有较高的转移倾向。尽管包括手术和化疗在内的治疗策略改善了OS患者的预后,但复发性OS的预后并不令人满意。导致OS患者死亡的主要原因是对目前使用的治疗方法的耐药性和随后的肺转移。然而,免疫疗法已被证明是一种有希望的治疗OS的策略。随着研究的深入,免疫疗法逐渐变得不可替代。本文提供了几种治疗策略的关键评估,包括免疫调节,疫苗治疗和免疫检查点封锁。
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引用次数: 1
The Design and Process of Ultrasound Guided Evaluation of Septic Arthritis in Emergency Departments 急诊科脓毒性关节炎超声引导评估的设计与过程
Pub Date : 2023-01-01 DOI: 10.26502/josm.511500099
Scott C Everett, Andrew L Alejo, Haley Durdella, Benjamin L Boswell
,
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引用次数: 0
A Commentary on the Negative Impacts on Patient Diagnoses and Management from the Lack of Magnetic Resonance Imaging (MRI) Services at the Ho Teaching Hospital (HTH) in Ghana 加纳Ho教学医院(HTH)缺乏磁共振成像(MRI)服务对患者诊断和管理的负面影响评论
Pub Date : 2023-01-01 DOI: 10.26502/josm.511500075
S. K. Angmorterh, K. Kekessie, E. Dzidzornu, S. Aboagye, Patience Nyamekye Agyemang, Nathaniel Awentiirin Angaag, Eric Kwasi Ofori
Magnetic Resonance Imaging (MRI) is a useful medical imaging tool in the diagnoses and management of several disease conditions including multiple sclerosis, prostate and breast cancer, epilepsy and seizure disorders, soft tissue joint disorders and vertebral spine disorders. MRI is also very useful in diagnosing breast disorders especially in younger women and following inconclusive breast ultrasound scans and mammograms. Pancreaticobiliary duct disorders like choledocholithiasis, acute and chronic pancreatitis are also well investigated with MRI. MRI services are unavailable at the Ho Teaching Hospital (HTH), a major referral hospital, and one of the five teaching hospitals in Ghana. The clinical implication of this is that patients who need MRI services have to travel long distances to other hospitals to access MRI services. The lack of MRI services at the HTH makes the diagnoses of critical medical conditions difficult, and in some cases, impossible. This commentary draws attention to the importance of MRI in the diagnoses and management of common medical conditions seen at the HTH and the lapses in diagnosing and managing patients with such conditions at the hospital.
磁共振成像(MRI)是一种有用的医学成像工具,用于诊断和治疗多种疾病,包括多发性硬化症、前列腺癌和乳腺癌、癫痫和发作性疾病、软组织关节疾病和脊椎疾病。核磁共振成像在诊断乳房疾病方面也非常有用,尤其是在年轻女性和不确定的乳房超声扫描和乳房x光检查之后。胰胆管疾病如胆总管结石、急性和慢性胰腺炎也可以用MRI进行很好的研究。加纳五所教学医院之一的主要转诊医院Ho教学医院(HTH)无法提供核磁共振成像服务。这一发现的临床意义是,需要核磁共振成像服务的患者必须长途跋涉到其他医院才能获得核磁共振成像服务。在HTH缺乏核磁共振服务使得诊断严重的医疗条件变得困难,在某些情况下,是不可能的。本评论提请注意MRI在HTH常见疾病的诊断和管理中的重要性,以及医院在诊断和管理此类疾病患者方面的失误。
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引用次数: 1
Epidemiological, Biological, Physical and Radiological Surveys for the Diagnosis of Adult Skeletal Fluorosis in the Rift Valley Region of Ethiopia: A Single Point Prevalence Study 埃塞俄比亚裂谷地区成人氟骨症诊断的流行病学、生物学、物理和放射学调查:单点患病率研究
Pub Date : 2023-01-01 DOI: 10.26502/josm.511500083
Heron Gezahegn
,
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引用次数: 0
Surgical Approaches in Total Hip Arthroplasty. 全髋关节置换术的手术入路。
Pub Date : 2023-01-01 DOI: 10.26502/josm.511500106
Rajiv Supra, Rajesh Supra, Devendra K Agrawal
The Total Hip Arthroplasty (THA) has become one of the most reliable surgical interventions that has improved the quality of life in many patients. THA allows patients to have increased mobility, range of motion, and reduced pain in patients with degenerative hip joints. This surgical procedure has become an effective treatment option for several chronic conditions affecting the hip joint. Although this surgery has been shown to give promising results in patients with hip pathology, selecting the approach for THA is a critical step in pre-operative planning. The best approach for this surgical procedure depends on multiple factors and each present with their own challenges, success rates, and limitations. To further elucidate the advantages and disadvantages associated with different surgical approaches, we critically review each surgical approach along with the different causes of failure of the THA procedure.
全髋关节置换术(THA)已成为最可靠的手术干预措施之一,改善了许多患者的生活质量。THA可以增加髋关节退行性患者的活动能力、活动范围和减轻疼痛。这种外科手术已成为影响髋关节的几种慢性疾病的有效治疗选择。尽管该手术已被证明对髋关节病变患者具有良好的疗效,但选择THA入路是术前计划的关键一步。这种手术的最佳方法取决于多种因素,每种因素都有自己的挑战、成功率和局限性。为了进一步阐明不同手术入路的优缺点,我们对每种手术入路以及THA手术失败的不同原因进行了批判性的回顾。
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引用次数: 0
Association of Serum Uric Acid with the Severity of Knee Osteoarthritis in a Tertiary Care Hospital 三级医院血清尿酸与膝关节骨性关节炎严重程度的关系
Pub Date : 2023-01-01 DOI: 10.26502/josm.511500077
Sarker S, K. T, Dinara Na, Sharmin S
Background: Osteoarthritis (OA) is the most common musculoskeletal condition and the most common cause of activity limitation among the middle aged and elderly population. Uric acid (UA) is constitutively present in normal cells, increased in concentration when cells are injured, and released from dying cells. Reaction of UA with oxidizing species generates UA radicals which is capable of causing biological damage. Several studies have previously showed an association between raised uric acid level and OA. Objectives: The objectives of this study were to determine the correlation between serum uric acid level and radiological severity of knee osteoarthritis according to Kellgren-Lawrence grading. Methods: This was a cross sectional study done among 80 cases of knee osteoarthritis for the period from August 2017 to May 2018 in Department of Physical Medicine and Rehabilitation, Bangabandhu Sheikh Mujib Medical University, (Shahbagh, Dhaka). Correlation between serum uric acid level and severity of knee osteoarthritis was made by Spearman’s rho correlation. Continuous variables were tested with paired t-tests. Ordinal variables were tested with Wilcoxon signed rank test. Results: Mean serum Uric Acid was 6.08 ± 1.11 mg/dl in male and 5.99 ± 0.97 mg/dl in female patients. Majority of the patients (42.5%) suffered from Grade 3 knee osteoarthritis radiologically. Maximum uric acid level was found (6.53 ± 1.54) in Grade 4 osteoarthritis. Mean Serum Uric acid Level was 5.85 ± 0.28 in Grade 3 and 5.52 ± 0.47 in Grade 2 knee osteoarthritis. Serum Uric acid level with severity of knee osteoarthritis Spearman’s rho correlation was done. There was significant correlation between severity of knee osteoarthritis and serum uric acid (rs=+0.288; p=0.013). Conclusions: Serum uric acid levels are significantly related to the radiological severity of knee osteoarthritis. The level of serum UA was found to be in increasing order, parallel to the grades of the disease.
背景:骨关节炎(OA)是中老年人群中最常见的肌肉骨骼疾病,也是导致活动受限的最常见原因。尿酸(UA)存在于正常细胞中,当细胞受损时浓度增加,并从死亡细胞中释放出来。UA与氧化物质反应产生的UA自由基能够造成生物损伤。先前有几项研究表明尿酸水平升高与OA之间存在关联。目的:本研究的目的是根据kelgren - lawrence分级确定血清尿酸水平与膝关节骨关节炎放射学严重程度之间的相关性。方法:这是一项横断面研究,对2017年8月至2018年5月在孟加拉国沙赫巴格的Bangabandhu Sheikh Mujib医科大学物理医学与康复学系进行的80例膝关节骨关节炎患者进行了研究。血清尿酸水平与膝关节骨性关节炎严重程度的相关性采用Spearman’s rho相关法。连续变量采用配对t检验。序数变量采用Wilcoxon符号秩检验。结果:男性患者平均血清尿酸为6.08±1.11 mg/dl,女性患者平均血清尿酸为5.99±0.97 mg/dl。大多数患者(42.5%)放射学表现为3级膝骨关节炎。4级骨关节炎患者尿酸水平最高(6.53±1.54)。3级膝关节骨性关节炎患者血清尿酸均值为5.85±0.28,2级膝关节骨性关节炎患者血清尿酸均值为5.52±0.47。测定血清尿酸水平与膝关节骨性关节炎严重程度的Spearman rho相关性。膝关节骨性关节炎严重程度与血清尿酸有显著相关性(rs=+0.288;p = 0.013)。结论:血清尿酸水平与膝关节骨关节炎的放射学严重程度显著相关。血清UA水平呈增加顺序,与疾病的等级平行。
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引用次数: 0
Testing IRCRA Battery and Its Predictive Value on Red-Point Performance in Youth Advanced Climbers IRCRA电池测试及其对青年高级攀登者红点表现的预测价值
Pub Date : 2023-01-01 DOI: 10.26502/josm.511500108
Antonia Ioana Vasile and, M. Stănescu
Introduction: Various studies examined the factors that influence climbing performance measuring the contribution of anthropometric factors, physiological factors, physical factors, technical factors, psychological factors and mental factors. IRCRA developed a battery with 10 tests that evaluate key physiological parameters in climbing. Hypothesis: We can predict climbing red-point performance based on the 5 factors: antropometric factor, upper body factor, flexibility factor, core factor and training factor. Methods: The study was performed on 17 youth advanced climbers both male and female. The evaluating instrument was IRCRA performance-related test battery for climbers with 3 more added tests: push-ups, dips and hanging crunches. Results: We composed five factors that influence red-point performance, which are, in order of their importance: training factors, upper body strength factors, anthropometric factors, core strength factor and flexibility factors. The model predicted 81.7% of the climbing performance variance. Power slap at Gullich rungs was the most predicting of the upper body strength. Conclusions: The most important factor for performance in climbing is a trainable skill: strength of the upper body. Specific training on specific holds is more important than general physical preparation. Anthropometric characteristics influence performance more than core strength or flexibility in climbing. Clinical relevance : We tested the efficiency of IRCRA battery in evaluating climbing performance and concluded that this battery can be used as a selection testing for competitions. This leads to better selection for competitions according to climbers’ level of preparation and can lead to less frequent injuries.
各种研究考察了影响攀岩成绩的因素,测量了人体测量因素、生理因素、物理因素、技术因素、心理因素和精神因素的贡献。IRCRA开发了一套包含10项测试的测试系统,用于评估攀爬过程中的关键生理参数。假设:我们可以根据5个因素来预测攀爬红点的表现:心肺因素、上身因素、柔韧性因素、核心因素和训练因素。方法:对17名男女青年攀登者进行研究。评估工具是登山者的IRCRA性能相关测试电池,另外还有3个额外的测试:俯卧撑、俯卧撑和仰卧起坐。结果:我们合成了影响红点成绩的5个因素,按其重要性依次为:训练因素、上身力量因素、人体测量因素、核心力量因素和柔韧性因素。该模型预测了81.7%的爬坡表现方差。用力拍打古利希梯级最能预测上肢力量。结论:影响攀岩成绩的最重要因素是一项可训练的技能:上肢力量。具体的握持训练比一般的身体准备更重要。人体测量特征比核心力量或柔韧性更能影响攀岩的表现。临床意义:我们测试了IRCRA电池在评估攀爬性能方面的效率,并得出结论,该电池可以用作比赛的选择测试。这样可以根据登山者的准备水平更好地选择比赛,并且可以减少受伤的频率。
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引用次数: 1
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Journal of orthopaedics and sports medicine
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