W. Ali, J. Iqbal, Talat Z. Mahmood, Liam Leonard, P. O’grady
Quadriceps tendon rupture is an uncommon injury but may result in long term disability if not adequately repaired. Many techniques are described for repair of acute quadriceps tendon rupture, including tendon-totendon repair, trans-osseous tunnels, synthetic augmentation, tendon plasty and the use of suture anchors. There is no single accepted surgical treatment. This study's objective was to assess the efficacy of a double-crossed suture anchor repair in the management of quadriceps tendon rupture. Materials and methods 85 patient attended our institute for surgical management of quadriceps tendon rupture over eight years (2012-2019). Twenty patients were treated with the use of a double-crossed suture anchor fixation. These patients were allowed to weight bear in a hinged knee brace for six weeks following surgery. Eighteen out of twenty patients had one or more predisposing comorbidities, including obesity, diabetes, renal failure, quinolone and steroid use. Results Clinical and functional outcomes were recorded during follow up visits prospectively for a mean of one year (10-14 months). The mean knee flexion was 124 degree (120-130). All patients were able to return to activities of daily living (ADL) with a mean of 2 J Surg Res 2022; 5 (1): 173-184 DOI: 10.26502/jsr.10020210 Journal of Surgery and Research Vol. 5 No. 1 March 2022. [ISSN 2640-1002] 174 months (1.5-3 months) and return to work at a mean of 6 months (4-8 months). The mean Tegner, Cincinnati and Lysholm score at the latest follow up were 2.8 (05), 79.2 (60-88) and 90 (70-100), respectively. There were no early complications. There was no re-tear reported at the latest follow up. Conclusion The double-crossed suture anchor fixation is a safe and effective treatment option in managing quadriceps tendon ruptures.
股四头肌肌腱断裂是一种罕见的损伤，但如果不适当修复，可能导致长期残疾。许多技术被描述用于修复急性股四头肌肌腱断裂，包括肌腱-肌腱修复，经骨隧道，合成增强，肌腱成形术和使用缝合锚。目前还没有单一的手术治疗方法。本研究的目的是评估双交叉缝合锚定修复治疗股四头肌肌腱断裂的疗效。材料与方法2012-2019年8年间，我院行股四头肌肌腱断裂手术治疗85例。20例患者采用双十字缝合锚定固定。这些患者被允许在手术后的六周内用铰链膝盖支架负重。20名患者中有18名患有一种或多种易感合并症，包括肥胖、糖尿病、肾衰竭、喹诺酮类药物和类固醇使用。结果平均随访1年(10-14个月)，记录临床及功能指标。平均膝关节屈曲度为124度(120-130度)。所有患者都能够恢复日常生活活动(ADL)，平均为2j Surg Res 2022;5 (1): 173-184 DOI: 10.26502/jsr.10020210《外科与研究杂志》第5卷第1期，2022年3月。[ISSN 2640-1002] 174个月(1.5-3个月)，平均6个月(4-8个月)重返工作岗位。最近一次随访时Tegner、Cincinnati和Lysholm的平均评分分别为2.8(05)、79.2(60-88)和90(70-100)。没有早期并发症。在最近的随访中没有再次撕裂的报道。结论双十字缝合锚定固定是治疗股四头肌肌腱断裂安全有效的方法。
{"title":"Double-Crossed Knotless Suture Anchor Repair of Quadriceps Tendon Rupture","authors":"W. Ali, J. Iqbal, Talat Z. Mahmood, Liam Leonard, P. O’grady","doi":"10.26502/jsr.10020210","DOIUrl":"https://doi.org/10.26502/jsr.10020210","url":null,"abstract":"Quadriceps tendon rupture is an uncommon injury but may result in long term disability if not adequately repaired. Many techniques are described for repair of acute quadriceps tendon rupture, including tendon-totendon repair, trans-osseous tunnels, synthetic augmentation, tendon plasty and the use of suture anchors. There is no single accepted surgical treatment. This study's objective was to assess the efficacy of a double-crossed suture anchor repair in the management of quadriceps tendon rupture. Materials and methods 85 patient attended our institute for surgical management of quadriceps tendon rupture over eight years (2012-2019). Twenty patients were treated with the use of a double-crossed suture anchor fixation. These patients were allowed to weight bear in a hinged knee brace for six weeks following surgery. Eighteen out of twenty patients had one or more predisposing comorbidities, including obesity, diabetes, renal failure, quinolone and steroid use. Results Clinical and functional outcomes were recorded during follow up visits prospectively for a mean of one year (10-14 months). The mean knee flexion was 124 degree (120-130). All patients were able to return to activities of daily living (ADL) with a mean of 2 J Surg Res 2022; 5 (1): 173-184 DOI: 10.26502/jsr.10020210 Journal of Surgery and Research Vol. 5 No. 1 March 2022. [ISSN 2640-1002] 174 months (1.5-3 months) and return to work at a mean of 6 months (4-8 months). The mean Tegner, Cincinnati and Lysholm score at the latest follow up were 2.8 (05), 79.2 (60-88) and 90 (70-100), respectively. There were no early complications. There was no re-tear reported at the latest follow up. Conclusion The double-crossed suture anchor fixation is a safe and effective treatment option in managing quadriceps tendon ruptures.","PeriodicalId":73961,"journal":{"name":"Journal of surgery and research","volume":"127 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76463237","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Talukder Mih, Naher N, Karim Smr, Hasan Km, Khan Si, Rahman Akms
This retrospective study was conducted to evaluate the clinico-pathological pattern of nodular goiter among patients who underwent thyroidectomy. This study included 50 patients following selection criteria. All patients were properly evaluated by history, clinical examination along with blood chemistry, ultrasonography, nuclear scanning and histopathology [fine needle aspiration cytology (FNAC)]. Out of 50 patients 38 were females and 12 were males, the male to female ratio was 1:3.12. Majority of the patients nodule and rest 3 cases were carcinoma. Among total study patients 46 were cold nodules and 4 were warm nodules. Histopathological reports of excised tissues revealed that 45 cases were papillary adenoma, 3 cases were papillary carcinoma and 2 cases were follicular carcinoma. The study concluded that solitary thyroid nodules are frequent at the middle age and predominant among females. Most of the patients of thyroid goiter are in euthyroid state and majority of nodules are benign lesions. Papillary adenoma is the most frequent benign nodular tumor followed by papillary carcinoma and then follicular carcinoma.
{"title":"Clinico Pathological Analysis of Nodular Goiter: A Retrospective Study","authors":"Talukder Mih, Naher N, Karim Smr, Hasan Km, Khan Si, Rahman Akms","doi":"10.26502/jsr.10020203","DOIUrl":"https://doi.org/10.26502/jsr.10020203","url":null,"abstract":"This retrospective study was conducted to evaluate the clinico-pathological pattern of nodular goiter among patients who underwent thyroidectomy. This study included 50 patients following selection criteria. All patients were properly evaluated by history, clinical examination along with blood chemistry, ultrasonography, nuclear scanning and histopathology [fine needle aspiration cytology (FNAC)]. Out of 50 patients 38 were females and 12 were males, the male to female ratio was 1:3.12. Majority of the patients nodule and rest 3 cases were carcinoma. Among total study patients 46 were cold nodules and 4 were warm nodules. Histopathological reports of excised tissues revealed that 45 cases were papillary adenoma, 3 cases were papillary carcinoma and 2 cases were follicular carcinoma. The study concluded that solitary thyroid nodules are frequent at the middle age and predominant among females. Most of the patients of thyroid goiter are in euthyroid state and majority of nodules are benign lesions. Papillary adenoma is the most frequent benign nodular tumor followed by papillary carcinoma and then follicular carcinoma.","PeriodicalId":73961,"journal":{"name":"Journal of surgery and research","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77546388","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Lodewijks Y, de Zoete JP, Van der Ven R, Schiffer A, Nienhuijs S
{"title":"Predicting Screening Factors for an Obesity Team’s Decision: A large Retrospective Cohort study","authors":"Lodewijks Y, de Zoete JP, Van der Ven R, Schiffer A, Nienhuijs S","doi":"10.26502/jsr.10020199","DOIUrl":"https://doi.org/10.26502/jsr.10020199","url":null,"abstract":"","PeriodicalId":73961,"journal":{"name":"Journal of surgery and research","volume":"15 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76839500","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Kanokrat Thaiwatcharamas, W. Loilome, S. Chusilp, Patchareeporn Tanming, P. Klanrit, Jutarop Phetcharaburanin
Introduction: This study aimed to characterize and compare the fecal microbial profiles between post pull-through Hirschsprung disease patients and healthy children aged younger than five years. Method: Fresh fecal samples were collected from 10 post pull-through Hirschsprung disease patients and age range-matched 10 healthy children. Bacterial DNA obtained from fecal samples were analyzed using 16S rRNA Illumina MiSeq platform. Results: Our findings demonstrated the significantly increased Firmicutes in Hirschsprung disease group compared to the healthy group (corrected p-value=0.007) at the phylum level. In addition, the Firmicutes/ Bacteroidetes ratio in Hirschsprung disease group was 4.8 times higher than that of its control counterpart. Bacilli were also significantly increased (corrected p-value=0.004), while Erysipelotrichi and Actinobacteria were significantly decreased in Hirschsprung disease patients (corrected p-value=0.04 and 0.03, respectively) at the class level. Moreover, functional analysis demonstrated that 20 enzymes and 18 Kyoto Encyclopedia of Genes and Genomes pathways were significantly different between groups (corrected p-value<0.01). Conclusion: A distinct dysbiosis even when the aganglionic segment had already been removed was remarkably evident in young children with Hirschsprung disease, with a significant increase in Firmicutes and a nearly five-fold increase in proportion of Firmicutes/Bacteroidetes which may potentially be employed as the dysbiosis-related biological indicator.
{"title":"Fecal Microbial Profiling of Young Hirschsprung Disease Children After Pull-Through Operation","authors":"Kanokrat Thaiwatcharamas, W. Loilome, S. Chusilp, Patchareeporn Tanming, P. Klanrit, Jutarop Phetcharaburanin","doi":"10.26502/jsr.10020261","DOIUrl":"https://doi.org/10.26502/jsr.10020261","url":null,"abstract":"Introduction: This study aimed to characterize and compare the fecal microbial profiles between post pull-through Hirschsprung disease patients and healthy children aged younger than five years. Method: Fresh fecal samples were collected from 10 post pull-through Hirschsprung disease patients and age range-matched 10 healthy children. Bacterial DNA obtained from fecal samples were analyzed using 16S rRNA Illumina MiSeq platform. Results: Our findings demonstrated the significantly increased Firmicutes in Hirschsprung disease group compared to the healthy group (corrected p-value=0.007) at the phylum level. In addition, the Firmicutes/ Bacteroidetes ratio in Hirschsprung disease group was 4.8 times higher than that of its control counterpart. Bacilli were also significantly increased (corrected p-value=0.004), while Erysipelotrichi and Actinobacteria were significantly decreased in Hirschsprung disease patients (corrected p-value=0.04 and 0.03, respectively) at the class level. Moreover, functional analysis demonstrated that 20 enzymes and 18 Kyoto Encyclopedia of Genes and Genomes pathways were significantly different between groups (corrected p-value<0.01). Conclusion: A distinct dysbiosis even when the aganglionic segment had already been removed was remarkably evident in young children with Hirschsprung disease, with a significant increase in Firmicutes and a nearly five-fold increase in proportion of Firmicutes/Bacteroidetes which may potentially be employed as the dysbiosis-related biological indicator.","PeriodicalId":73961,"journal":{"name":"Journal of surgery and research","volume":"302 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90489583","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Rishwanth Vetri, Surabhi Sainath, Vishmita Kannichamy, Amit Banerjee
Appendicitis is the most common cause of surgical abdomen. Delay in the diagnosis and appropriate management may lead to potentially life-threatening complications. Bilirubin is associated with the assessment of the severity of appendicitis. The objective of the study is to determine the role of hyperbilirubinemia in predicting appendiceal perforation. An online search was conducted in PubMed, Google Scholar, and PubMed Central to find relevant publications relating to hyperbilirubinemia in perforated appendicitis. Only studies conducted on humans were included. Out of the 1287 articles found, only seven were included in our final review. Of the seven articles included in the review, hyperbilirubinemia is confirmed as a useful predictor for perforated appendicitis or a marker of the severity of appendicitis. Preoperative bilirubin levels can be used as a diagnostic tool in perforated.
{"title":"Hyperbilirubinemia as a Predictor of Perforated Appendicitis","authors":"Rishwanth Vetri, Surabhi Sainath, Vishmita Kannichamy, Amit Banerjee","doi":"10.26502/jsr.10020245","DOIUrl":"https://doi.org/10.26502/jsr.10020245","url":null,"abstract":"Appendicitis is the most common cause of surgical abdomen. Delay in the diagnosis and appropriate management may lead to potentially life-threatening complications. Bilirubin is associated with the assessment of the severity of appendicitis. The objective of the study is to determine the role of hyperbilirubinemia in predicting appendiceal perforation. An online search was conducted in PubMed, Google Scholar, and PubMed Central to find relevant publications relating to hyperbilirubinemia in perforated appendicitis. Only studies conducted on humans were included. Out of the 1287 articles found, only seven were included in our final review. Of the seven articles included in the review, hyperbilirubinemia is confirmed as a useful predictor for perforated appendicitis or a marker of the severity of appendicitis. Preoperative bilirubin levels can be used as a diagnostic tool in perforated.","PeriodicalId":73961,"journal":{"name":"Journal of surgery and research","volume":"2014 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86548306","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
A. Soltani, I. Ahrari, Meisam Eqbal, Seyed Hossein Owji, Amir Mousaie Amin, Z. Khosravizadegan, M. Ghavipisheh, A. Rezaianzadeh, Hadi Raeisi Shahraki
Primary Malignant Brain Tumor Trends 2001- 2017: An Alarming Increase In Glioblastoma. Journal of Surgery and Research 5 (2022): 284-295. Abstract Introduction Primary Brain tumors which include a 1.7 percent of all cancers among Data was obtained from Population-based according to WHO 2007 classification of CNS tumors was used for grouping the tumors. Using SPSS, Total Growth Rate (TGR) and Incidence Rate (IR) were calculated to assess the changes overtime. Results A total number of 2130 (male: 890, 41.8% and female: 1240, 58.2%) brain tumor cases from 2001 to 2017 were included in this study. The highest Incidence Rate (IR) was found in ‘unspecified tumors of the brain’ (2.74 per 100000) between 2011 and 2015 followed by ‘Astrocytoma’ (1.34 per 100000) between 2006 and 2010) and ‘Glioblastoma’ (1.25 per 100000) between years 2011 and 2016. Additionally, the Glioblastoma showed the highest IR in those aged between 30 and 59 of years (0.42 per 100000). An upward trend in the rate of brain tumors in the province could be an for more studies to be done especially from the point of view.
{"title":"Primary Malignant Brain Tumor Trends in Southern Iran, 2001- 2017: An Alarming increase in Glioblastoma","authors":"A. Soltani, I. Ahrari, Meisam Eqbal, Seyed Hossein Owji, Amir Mousaie Amin, Z. Khosravizadegan, M. Ghavipisheh, A. Rezaianzadeh, Hadi Raeisi Shahraki","doi":"10.26502/jsr.10020222","DOIUrl":"https://doi.org/10.26502/jsr.10020222","url":null,"abstract":"Primary Malignant Brain Tumor Trends 2001- 2017: An Alarming Increase In Glioblastoma. Journal of Surgery and Research 5 (2022): 284-295. Abstract Introduction Primary Brain tumors which include a 1.7 percent of all cancers among Data was obtained from Population-based according to WHO 2007 classification of CNS tumors was used for grouping the tumors. Using SPSS, Total Growth Rate (TGR) and Incidence Rate (IR) were calculated to assess the changes overtime. Results A total number of 2130 (male: 890, 41.8% and female: 1240, 58.2%) brain tumor cases from 2001 to 2017 were included in this study. The highest Incidence Rate (IR) was found in ‘unspecified tumors of the brain’ (2.74 per 100000) between 2011 and 2015 followed by ‘Astrocytoma’ (1.34 per 100000) between 2006 and 2010) and ‘Glioblastoma’ (1.25 per 100000) between years 2011 and 2016. Additionally, the Glioblastoma showed the highest IR in those aged between 30 and 59 of years (0.42 per 100000). An upward trend in the rate of brain tumors in the province could be an for more studies to be done especially from the point of view.","PeriodicalId":73961,"journal":{"name":"Journal of surgery and research","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90164808","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Study of Correlation between Serum Amylase and Serum Lipase level with Percentage of Necrosis on CECT in Acute Necrotising Pancreatitis","authors":"Shifa A. Kalokhe, Lisha Suraj, Shrutik Devdikar","doi":"10.26502/jsr.10020239","DOIUrl":"https://doi.org/10.26502/jsr.10020239","url":null,"abstract":"","PeriodicalId":73961,"journal":{"name":"Journal of surgery and research","volume":"74 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77179606","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Wilms tumor is the commonest childhood tumor. Extra renal Wilms' tumor is a nephroblastoma arising in locations other than kidneys. The tumor arises from misplaced metanephric blastema or is contemplated to arise from pluriotent cells. A metstasis, origin of tumor in kidneys and supernumery kidneys have to be ruled out to assign a diagnosis of extrarenal Wilms' tumor. It has been commonly reported to occur in retroperitoneum but also in inguinal region, pelvis, testis and colon. The age of occurence has been reported as Wilms; tumor in literature. It is mostly diagnosed post operatively. A preoperative biopsy combined with immunohistochemistry can help in diagnosing tumors in cases where neoadjuvant chemotherapy is anticipated. The WIlms'tumors in extrarenal location largely have favourable histology and are treated on same guidelines as Wilms' tumor. Here we present a case of extra renal Wilms' tumor arising in left lobe of liver. Liver as location for an extra renal Wilms' tumor was not found in literature.
{"title":"Extra-Renal Wilms’ Tumor in Left Lobe of Liver: A Case Report of the Rare Tumor with Review of Literature","authors":"Ajay Krishna Boralkar, Manoj Narayanrao More, Kunal Vikram Singh, Arpita Khandelwal, Aditya Abhijeet Phadke","doi":"10.26502/jsr.10020234","DOIUrl":"https://doi.org/10.26502/jsr.10020234","url":null,"abstract":"Wilms tumor is the commonest childhood tumor. Extra renal Wilms' tumor is a nephroblastoma arising in locations other than kidneys. The tumor arises from misplaced metanephric blastema or is contemplated to arise from pluriotent cells. A metstasis, origin of tumor in kidneys and supernumery kidneys have to be ruled out to assign a diagnosis of extrarenal Wilms' tumor. It has been commonly reported to occur in retroperitoneum but also in inguinal region, pelvis, testis and colon. The age of occurence has been reported as Wilms; tumor in literature. It is mostly diagnosed post operatively. A preoperative biopsy combined with immunohistochemistry can help in diagnosing tumors in cases where neoadjuvant chemotherapy is anticipated. The WIlms'tumors in extrarenal location largely have favourable histology and are treated on same guidelines as Wilms' tumor. Here we present a case of extra renal Wilms' tumor arising in left lobe of liver. Liver as location for an extra renal Wilms' tumor was not found in literature.","PeriodicalId":73961,"journal":{"name":"Journal of surgery and research","volume":"132 8 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79616425","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Alejandro Flores Uribe, Jorge Alberto González Arévalo, Diego Bolaños Maya, Eduardo Chávez Ornelas, Roberto Martínez Mejorada
{"title":"Diagnosis and Surgical Management with Immediate Breast Reconstruction of atypical Borderline Phyllodes tumor: Case Report","authors":"Alejandro Flores Uribe, Jorge Alberto González Arévalo, Diego Bolaños Maya, Eduardo Chávez Ornelas, Roberto Martínez Mejorada","doi":"10.26502/jsr.10020265","DOIUrl":"https://doi.org/10.26502/jsr.10020265","url":null,"abstract":"","PeriodicalId":73961,"journal":{"name":"Journal of surgery and research","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82222018","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Gilles Houvenaeghel, Alexandre de Nonneville, Monique Cohen, Frédéric Viret, Sandrine Rua, Laura Sabiani, Max Buttarelli, Emmanuelle Charaffe, Audrey Monneur, Aurélie Jalaguier-Coudray, Marie Bannier, Renaud Sabatier, Anthony Gonçalves
We examined characteristics trends in early breast cancer patients receiving neoadjuvant chemotherapy (NAC) over a 16-year period. Our primary objective was to analyze variations in tumor stage and subtype over time. Secondary objectives included analyses of type of surgery and pathological response, from January 2005 to May 2021, 1623 patients receiving NAC were identified. Three periods were determined: 2005-2009 (P1), 2010-2014 (P2), 2015-2021 (P3). Correlations between periods and patient features with cT stage, pathological breast and axillary node response, pathological complete response (pCR), and type of surgery were assessed in univariate and multivariate analyses. We observed a significant increase in cT0-1 and N0 stages with periods (from 6.8% at P1 to 21.2% at P3, and from 43.2% at P1 to 55.9% at P3, respectively) and in the proportion of HER2+ and triple negative (TN) subtypes. In a multivariate analysis, a decrease of cT2-3-4 tumors during P3 was observed for HER2+ (OR:0.174; p=0.004) and TN tumors (OR:0.287; p=0.042). In-breast pCR and pCR were observed in 40.8% and 34.4% of all patients, respectively, with strong association with tumor subtypes, but not with tumor size in multivariate analysis (37.0% pCR for cT0-1 tumors, 36.4% for cT2 tumors, 29.1% for cT3 tumors (cT0-1 versus cT≥2; p=0.222)). pCR was negatively associated with cN1 stage (OR:1.499; p<0.001 for cN1 patients compared to cN0). We observed an increase in the proportion of small cT0-1 and N0 stages treated with NAC, especially in HER2+ and TN subtypes. No significant impact of tumor size on pCR rates was found.
{"title":"Neoadjuvant Chemotherapy for Breast Cancer: Evolution of Clinical Practice in a French Cancer Center Over 16 Years and Pathologic Response Rates According to Tumor Subtypes and Clinical Tumor Size: Retrospective Cohort Study.","authors":"Gilles Houvenaeghel, Alexandre de Nonneville, Monique Cohen, Frédéric Viret, Sandrine Rua, Laura Sabiani, Max Buttarelli, Emmanuelle Charaffe, Audrey Monneur, Aurélie Jalaguier-Coudray, Marie Bannier, Renaud Sabatier, Anthony Gonçalves","doi":"10.26502/jsr.10020251","DOIUrl":"https://doi.org/10.26502/jsr.10020251","url":null,"abstract":"<p><p>We examined characteristics trends in early breast cancer patients receiving neoadjuvant chemotherapy (NAC) over a 16-year period. Our primary objective was to analyze variations in tumor stage and subtype over time. Secondary objectives included analyses of type of surgery and pathological response, from January 2005 to May 2021, 1623 patients receiving NAC were identified. Three periods were determined: 2005-2009 (P1), 2010-2014 (P2), 2015-2021 (P3). Correlations between periods and patient features with cT stage, pathological breast and axillary node response, pathological complete response (pCR), and type of surgery were assessed in univariate and multivariate analyses. We observed a significant increase in cT0-1 and N0 stages with periods (from 6.8% at P1 to 21.2% at P3, and from 43.2% at P1 to 55.9% at P3, respectively) and in the proportion of HER2+ and triple negative (TN) subtypes. In a multivariate analysis, a decrease of cT2-3-4 tumors during P3 was observed for HER2+ (OR:0.174; p=0.004) and TN tumors (OR:0.287; p=0.042). In-breast pCR and pCR were observed in 40.8% and 34.4% of all patients, respectively, with strong association with tumor subtypes, but not with tumor size in multivariate analysis (37.0% pCR for cT0-1 tumors, 36.4% for cT2 tumors, 29.1% for cT3 tumors (cT0-1 versus cT≥2; p=0.222)). pCR was negatively associated with cN1 stage (OR:1.499; p<0.001 for cN1 patients compared to cN0). We observed an increase in the proportion of small cT0-1 and N0 stages treated with NAC, especially in HER2+ and TN subtypes. No significant impact of tumor size on pCR rates was found.</p>","PeriodicalId":73961,"journal":{"name":"Journal of surgery and research","volume":"5 3","pages":"511-525"},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9879000/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10646830","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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