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Addressing Knowledge Gaps in Patients With High-Risk Peripheral Artery Disease 缩小高危外周动脉疾病患者的知识差距
Pub Date : 2024-10-01 DOI: 10.1016/j.jscai.2024.102286
R. Kevin Rogers MD, MSc , Marc P. Bonaca MD, MPH
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引用次数: 0
Outcome of Saphenous Vein Graft Percutaneous Coronary Intervention Using Contemporary Drug-Eluting Stents: A SCAAR Report 使用当代药物洗脱支架进行隐静脉移植经皮冠状动脉介入治疗的结果:SCAAR 报告
Pub Date : 2024-10-01 DOI: 10.1016/j.jscai.2024.102232
Saman Saidi-Seresht MD , Stefan James MD, PhD , David Erlinge MD, PhD , Sasha Koul MD, PhD , Bo Lagerqvist MD, PhD , Moman Mohammad MD, PhD , Henrik Renlund PhD , Per Grimfjärd MD, PhD

Background

Percutaneous coronary intervention (PCI) of saphenous vein grafts (SVG) is associated with poor outcomes and is often regarded as inferior to native vessel PCI. We investigated clinical outcomes of SVG-PCI using contemporary drug-eluting stents (DES), in a complete, nationwide population.

Methods

The complete Swedish Coronary Angiography and Angioplasty Registry (SCAAR) was used to identify all patients in Sweden who underwent SVG-PCI with a contemporary DES between 2013 and 2020. Baseline characteristics, procedures, and outcomes were described.

Results

A total of 2198 SVG-PCI procedures with 3106 contemporary DES were included. Patients had a high incidence of comorbidities such as diabetes (40%), prior myocardial infarction (MI) (69%), and acute coronary syndrome (74%) at presentation. SVG-PCI procedures commonly involved multiple DES (41%). Native vessel PCI, in addition to SVG-PCI, was performed in only 13% of procedures. At 1 year, adverse clinical outcomes were frequent as exemplified by any death (9.2%), MI (9.1%), or revascularization (21.1%), whereas stent and lesion-related outcomes on a patient level were less common: stent thrombosis (1.2%), in-stent restenosis (4.3%) and target lesion revascularization (4.3%). Similarly, at 3 years, clinical outcomes were frequent: death (19.8%), MI (21.1%), revascularization (32.8%); and stent-related outcomes were less common: stent thrombosis (2.9%), restenosis (10.8), and target lesion revascularization (13.6%).

Conclusions

In this nationwide cohort of patients who underwent SVG-PCI with contemporary DES, patients were characterized by a high-risk profile and high rates of adverse clinical events. However, the incidence of stent and lesion-related events was low.
背景大隐静脉移植物(SVG)经皮冠状动脉介入治疗(PCI)的疗效不佳,通常被认为不如原血管PCI。我们在一个完整的全国性人群中调查了使用现代药物洗脱支架(DES)进行SVG-PCI的临床疗效。方法利用完整的瑞典冠状动脉造影和血管成形术登记处(SCAAR)来识别2013年至2020年间瑞典所有使用现代DES进行SVG-PCI的患者。结果 共纳入了2198例使用3106个当代DES的SVG-PCI手术。患者发病时合并糖尿病(40%)、既往心肌梗死(69%)和急性冠脉综合征(74%)的比例较高。SVG-PCI手术通常涉及多个DES(41%)。除SVG-PCI外,仅有13%的手术进行了原发血管PCI。1年后,不良临床结果频频出现,如死亡(9.2%)、心肌梗死(9.1%)或血管再通(21.1%),而支架和病变相关的患者结果则较少见:支架血栓(1.2%)、支架内再狭窄(4.3%)和靶病变血管再通(4.3%)。同样,3年后的临床结果为:死亡(19.8%)、心肌梗死(21.1%)、血运重建(32.8%);支架相关结果为:支架血栓(2.9%)、支架内再狭窄(10.8%)和靶病变血运重建(13.6%)。然而,支架和病变相关事件的发生率较低。
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引用次数: 0
DETECT-DVT: Detroit Evaluation of Thrombectomy and Evaluation of Intravascular Ultrasound in Deep Vein Thrombosis DETECT-DVT:深静脉血栓形成中血栓切除术的底特律评估和血管内超声评估
Pub Date : 2024-10-01 DOI: 10.1016/j.jscai.2024.102153
Sabina Kumar MS, DO , Brian Ballard DO , Umeh Chukwuemeka MD , Anthony Teta MD , Mustafa Turkmani MD , Anuraag Khandavalli MD , Samuel Reenders MS, DO , Arjun Chadha MD , Marian Canon MD , Saman Barznji MD , Jason Kaplan MD , Varun Yelamanchilli MD , Brandon Ballard BS , Mark Zainea MD , Jay Mohan DO

Background

We sought to evaluate the use of intravascular ultrasound (IVUS) and mechanical thrombectomy (MT) for the treatment of deep vein thrombosis (DVT) in a community hospital setting.

Methods

Data were analyzed among patients with lower extremity DVT who underwent MT from December 1, 2021 to December 1, 2022.

Results

A total of 1263 patients were evaluated and only 8.8% of patients with DVT received intervention. Of them, 42% were women. The mean age and length of stay were 61.3 years and 3.5 days, respectively. For cases that proceeded to intervention, IVUS was used in 89% of cases, 80% received venoplasty, and 30% received stents. The mean number of MT passes was 4 and the mean contrast volume used was 71 mL. Flow was restored in 96.7% of cases. The procedure was unable to be completed in 1.8% of the cases, and 1.8% had a reported complication after the procedure. Vascular surgery was consulted in 64.4% of the cases, cardiology in 33%, interventional radiology in 12.5%, and 10.9% of the patients had multiple consults. MT was associated with postprocedure reduction of hemoglobin levels (13.4 vs 12.1; P < .001) and no change in postprocedure creatinine levels (1.08 vs 1.04; P = .28). IVUS was associated with fewer passes, although this was not statistically significant (P = .09). Additionally, IVUS was associated with increased stenting (P = .03) and venoplasty (P < .001).

Conclusions

MT is shown to be successful in restoring venous flow and is utilized by multiple specialties in the treatment of DVT. Additionally, IVUS was widely used in conjunction with MT, and it was associated with increased advanced interventions, such as venoplasty and stent placement.
背景我们试图评估在社区医院环境中使用血管内超声(IVUS)和机械血栓切除术(MT)治疗深静脉血栓形成(DVT)的情况。方法对2021年12月1日至2022年12月1日期间接受MT治疗的下肢DVT患者的数据进行分析。其中,42%为女性。平均年龄和住院时间分别为 61.3 岁和 3.5 天。在进行介入治疗的病例中,89%使用了IVUS,80%接受了静脉成形术,30%接受了支架治疗。MT的平均通过次数为4次,平均造影剂用量为71毫升。96.7%的病例恢复了血流。1.8%的病例无法完成手术,1.8%的病例术后出现并发症。64.4%的病例咨询了血管外科,33%的病例咨询了心脏科,12.5%的病例咨询了介入放射科,10.9%的患者进行了多次咨询。MT 与术后血红蛋白水平降低有关(13.4 vs 12.1;P < .001),而术后肌酐水平无变化(1.08 vs 1.04;P = .28)。IVUS与较少的通过次数有关,但无统计学意义(P = .09)。此外,IVUS 与更多的支架植入术(P = .03)和静脉成形术(P < .001)相关。此外,IVUS 与 MT 结合使用非常广泛,而且与静脉成形术和支架置入术等高级干预措施的增加有关。
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引用次数: 0
Successful Percutaneous Treatment of Left Main Artery Occlusion Associated With Focal Type A Aortic Dissection 成功经皮治疗伴有局灶性 A 型主动脉夹层的左主干动脉闭塞症
Pub Date : 2024-10-01 DOI: 10.1016/j.jscai.2024.102293
Ashraf Samhan MD , Anjan Tibrewala MD , Anirudh Kumar MD
Type A aortic dissection is a rapidly progressive disease process with often fatal complications. We present a case of focal Type A aortic dissection complicated by left main occlusion and cardiogenic shock, treated with percutaneous coronary intervention and mechanical circulatory support.
A 型主动脉夹层是一种进展迅速的疾病,通常会出现致命的并发症。我们报告了一例局灶性 A 型主动脉夹层并发左主干闭塞和心源性休克的病例,患者接受了经皮冠状动脉介入治疗和机械循环支持治疗。
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引用次数: 0
Cover 封面
Pub Date : 2024-10-01 DOI: 10.1016/S2772-9303(24)02088-X
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引用次数: 0
Balancing Affordability and Need: Should We Use Renal Denervation in Hypertension Management? 平衡经济承受能力与需求:我们是否应该在高血压治疗中使用肾脏去神经支配?
Pub Date : 2024-10-01 DOI: 10.1016/j.jscai.2024.102248
Lucas Lauder MD , Thilo Burkard MD , Felix Mahfoud MD, MA
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引用次数: 0
A Single-Center Review of Clinical Outcomes After Transcatheter Relief of Superior Vena Cava Stenosis in a Pediatric and Young Adult Population 经导管缓解小儿和青少年上腔静脉狭窄后临床疗效的单中心综述
Pub Date : 2024-10-01 DOI: 10.1016/j.jscai.2024.102245
Sarah Pradhan MD, MSc , Sarosh P. Batlivala MD, MSCI , Luisa Raga Pombo MD , Nicholas Ollberding PhD , Zhiqian Gao PhD, MSPH , Nicholas Szugye MD, MSc , Shabana Shahanavaz MBBS , Russel Hirsch MD

Background

The suspected etiology of superior vena cava (SVC) obstruction is predominantly iatrogenic. Transcatheter interventions relieve stenosis with good long-term results, although there is a paucity of published data in pediatrics. We aim to describe patient characteristics and clinical outcomes after transcatheter SVC intervention at a single-center pediatric quaternary care center.

Methods

Single-center, retrospective study of all pediatric and young adult patients who underwent transcatheter SVC intervention from December 2006 to January 2020. SVC gradients and changes in vessel diameter were compared using paired-sample t-tests. Balloon and stent cohorts were compared using the Wilcoxon rank sum test or Fisher exact χ2 test. Reintervention was compared between balloon and stent cohorts using the McNemar test to determine if initial procedural type was associated with reintervention. Time to reintervention was compared between balloon vs stent cohorts using Kaplan-Meier survival analysis with a log-rank test.

Results

A total of 42 patients (median age, 1.5 years; IQR, 0.31-15; 64.2% male) underwent 81 procedures with 1 minor complication and no mortality attributed to the procedure. Most (71.4%) patients were asymptomatic. Affected patient subgroups include those with a history of central venous line (92.9%), congenital heart disease (76.2%), postorthotopic heart transplant (42.9%), post-ECMO (31.0%), and history of surgical baffling or SVC surgery (9.5%). Those who underwent initial balloon angioplasty were significantly younger and smaller than those with an initial stent. Significantly lower pressure gradients and larger SVC dimensions were achieved after stenting. The majority of patients (54.8%) resolved after initial balloon angioplasty and reintervention rates were similar between initial balloon angioplasty and stent, although reintervention trended toward being earlier after the balloon.

Conclusions

Transcatheter SVC intervention in pediatrics is acutely effective and safe in relieving SVC obstruction in all subgroups. Reintervention rates are similar between balloon and stenting, with balloon tending to be earlier, with the majority resolving after initial intervention. Further research is necessary to investigate the most effective transcatheter intervention for each patient subgroup.
背景上腔静脉(SVC)阻塞的疑似病因主要是先天性的。经导管介入治疗可缓解狭窄,并具有良好的长期效果,但在儿科领域发表的数据很少。方法对 2006 年 12 月至 2020 年 1 月期间接受经导管 SVC 介入治疗的所有儿童和年轻成人患者进行单中心回顾性研究。采用配对样本t检验比较SVC梯度和血管直径的变化。使用 Wilcoxon 秩和检验或 Fisher exact χ2 检验比较球囊和支架队列。使用 McNemar 检验比较球囊和支架队列之间的再介入情况,以确定初始手术类型是否与再介入有关。结果 共有 42 名患者(中位年龄为 1.5 岁;IQR 为 0.31-15;64.2% 为男性)接受了 81 例手术,其中 1 例为轻微并发症,无死亡病例。大多数患者(71.4%)无症状。受影响的患者亚群包括有中心静脉置管病史者(92.9%)、先天性心脏病患者(76.2%)、异位心脏移植术后患者(42.9%)、ECMO术后患者(31.0%)以及有外科挡板或SVC手术史者(9.5%)。初次接受球囊血管成形术的患者明显比初次接受支架植入术的患者更年轻、更瘦小。支架植入术后,压力梯度明显降低,SVC尺寸明显增大。大多数患者(54.8%)在最初的球囊血管成形术后病情得到缓解,最初的球囊血管成形术和支架术的再介入率相似,但球囊术后再介入的时间有提前的趋势。球囊和支架置入术的再介入率相似,球囊置入术的再介入率更早,大多数患者在初次介入后就能解决问题。有必要开展进一步的研究,探讨针对不同患者亚群最有效的经导管介入治疗方法。
{"title":"A Single-Center Review of Clinical Outcomes After Transcatheter Relief of Superior Vena Cava Stenosis in a Pediatric and Young Adult Population","authors":"Sarah Pradhan MD, MSc ,&nbsp;Sarosh P. Batlivala MD, MSCI ,&nbsp;Luisa Raga Pombo MD ,&nbsp;Nicholas Ollberding PhD ,&nbsp;Zhiqian Gao PhD, MSPH ,&nbsp;Nicholas Szugye MD, MSc ,&nbsp;Shabana Shahanavaz MBBS ,&nbsp;Russel Hirsch MD","doi":"10.1016/j.jscai.2024.102245","DOIUrl":"10.1016/j.jscai.2024.102245","url":null,"abstract":"<div><h3>Background</h3><div>The suspected etiology of superior vena cava (SVC) obstruction is predominantly iatrogenic. Transcatheter interventions relieve stenosis with good long-term results, although there is a paucity of published data in pediatrics. We aim to describe patient characteristics and clinical outcomes after transcatheter SVC intervention at a single-center pediatric quaternary care center.</div></div><div><h3>Methods</h3><div>Single-center, retrospective study of all pediatric and young adult patients who underwent transcatheter SVC intervention from December 2006 to January 2020. SVC gradients and changes in vessel diameter were compared using paired-sample t-tests. Balloon and stent cohorts were compared using the Wilcoxon rank sum test or Fisher exact χ<sup>2</sup> test. Reintervention was compared between balloon and stent cohorts using the McNemar test to determine if initial procedural type was associated with reintervention. Time to reintervention was compared between balloon vs stent cohorts using Kaplan-Meier survival analysis with a log-rank test.</div></div><div><h3>Results</h3><div>A total of 42 patients (median age, 1.5 years; IQR, 0.31-15; 64.2% male) underwent 81 procedures with 1 minor complication and no mortality attributed to the procedure. Most (71.4%) patients were asymptomatic. Affected patient subgroups include those with a history of central venous line (92.9%), congenital heart disease (76.2%), postorthotopic heart transplant (42.9%), post-ECMO (31.0%), and history of surgical baffling or SVC surgery (9.5%). Those who underwent initial balloon angioplasty were significantly younger and smaller than those with an initial stent. Significantly lower pressure gradients and larger SVC dimensions were achieved after stenting. The majority of patients (54.8%) resolved after initial balloon angioplasty and reintervention rates were similar between initial balloon angioplasty and stent, although reintervention trended toward being earlier after the balloon.</div></div><div><h3>Conclusions</h3><div>Transcatheter SVC intervention in pediatrics is acutely effective and safe in relieving SVC obstruction in all subgroups. Reintervention rates are similar between balloon and stenting, with balloon tending to be earlier, with the majority resolving after initial intervention. Further research is necessary to investigate the most effective transcatheter intervention for each patient subgroup.</div></div>","PeriodicalId":73990,"journal":{"name":"Journal of the Society for Cardiovascular Angiography & Interventions","volume":"3 10","pages":"Article 102245"},"PeriodicalIF":0.0,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142528932","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Corrigenda to Abstracts in issue 3/5S of the Journal of the Society for Cardiovascular Angiography & Interventions 心血管血管造影和介入学会杂志》第 3/5S 期摘要勘误表
Pub Date : 2024-10-01 DOI: 10.1016/j.jscai.2024.102246
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引用次数: 0
Contemporary Saphenous Vein Graft Intervention: New Insights but Still More Questions 当代无隐静脉移植介入治疗:新见解但仍有更多问题
Pub Date : 2024-10-01 DOI: 10.1016/j.jscai.2024.102282
Giorgio A. Medranda MD , Sandeep Nathan MD, MSc
{"title":"Contemporary Saphenous Vein Graft Intervention: New Insights but Still More Questions","authors":"Giorgio A. Medranda MD ,&nbsp;Sandeep Nathan MD, MSc","doi":"10.1016/j.jscai.2024.102282","DOIUrl":"10.1016/j.jscai.2024.102282","url":null,"abstract":"","PeriodicalId":73990,"journal":{"name":"Journal of the Society for Cardiovascular Angiography & Interventions","volume":"3 10","pages":"Article 102282"},"PeriodicalIF":0.0,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142528920","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Catheter-Based Radiofrequency Renal Denervation in the United States: A Cost-Effectiveness Analysis Based on Contemporary Evidence 美国基于导管的射频肾脏去神经支配:基于当代证据的成本效益分析
Pub Date : 2024-10-01 DOI: 10.1016/j.jscai.2024.102234
David E. Kandzari MD , Khoa N. Cao MBBS, MPH, MS , Anne M. Ryschon MA , Andrew S.P. Sharp MBChB, MD , Jan B. Pietzsch PhD

Background

Catheter-based radiofrequency renal denervation (RF RDN) has recently been approved as an adjunctive treatment for hypertensive patients without adequate blood pressure control. This study assessed the cost-effectiveness of RF RDN in the United States based on contemporary clinical evidence.

Methods

A decision-analytic Markov model projected costs, quality-adjusted life years (QALY), and clinical events for an active cohort treated with RF RDN and a control cohort treated with standard-of-care (defined as 1, 2, or 3 antihypertensive medications). Cohort demographics and therapy effect were derived from the SPYRAL HTN-ON MED study demonstrating an absolute 9.9 mm Hg reduction in office systolic blood pressure and 4.9 mm Hg reduction compared with sham control. Clinical event risk reduction from blood pressure lowering was based on a meta-regression of 47 hypertension trials. The incremental cost-effectiveness ratio was evaluated against willingness-to-pay thresholds of $50,000 per QALY (high value) and $150,000 per QALY (intermediate value). Extensive scenario and sensitivity analyses were conducted to assess robustness of the findings.

Results

RF RDN yielded a significant risk reduction in clinical events (0.80 for stroke, 0.88 for myocardial infarction, and 0.85 for cardiovascular death over 10 years). Over lifetime, RF RDN added 0.34 QALY at an additional cost of $11,275, leading to an incremental cost-effectiveness ratio of $32,732 per QALY. The cost-effectiveness of RF RDN was robust across a broad range of scenarios and sensitivity analyses.

Conclusions

Based on a lifetime projection, catheter-based RF RDN is a cost-effective, high-value intervention for hypertensive patients with uncontrolled hypertension.
背景导管射频肾脏去神经支配(RF RDN)最近被批准作为血压控制不佳的高血压患者的辅助治疗手段。该研究根据当代临床证据评估了 RF RDN 在美国的成本效益。方法一个决策分析马尔可夫模型预测了接受 RF RDN 治疗的活跃队列和接受标准护理(定义为 1、2 或 3 种降压药)治疗的对照队列的成本、质量调整生命年 (QALY) 和临床事件。队列人口统计学和治疗效果来自 SPYRAL HTN-ON MED 研究,该研究显示,与假对照组相比,诊室收缩压绝对值降低了 9.9 mm Hg,降低了 4.9 mm Hg。降压带来的临床事件风险降低是基于 47 项高血压试验的元回归结果。根据每 QALY 5 万美元(高值)和每 QALY 15 万美元(中值)的支付意愿阈值对增量成本效益比进行了评估。结果RF RDN显著降低了临床事件风险(10年内中风风险为0.80,心肌梗死风险为0.88,心血管死亡风险为0.85)。在整个生命周期中,RF RDN 增加了 0.34 QALY,额外成本为 11,275 美元,因此每 QALY 的增量成本效益比为 32,732 美元。RF RDN 的成本效益在各种情况和敏感性分析中都是稳健的。结论根据终生预测,对于未得到控制的高血压患者而言,基于导管的 RF RDN 是一项具有成本效益的高价值干预措施。
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引用次数: 0
期刊
Journal of the Society for Cardiovascular Angiography & Interventions
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