Background
This study compares outcomes between percutaneous ventricular assist device (PVAD)-supported and intra-aortic balloon pump (IABP)-supported high-risk percutaneous coronary intervention (HRPCI) in a large-scale, contemporary hospital administrative dataset.
Methods
Patients undergoing HRPCI supported by PVAD or IABP between January 1, 2018, and April 30, 2024, were identified in the Premier Healthcare Database. Patients were excluded if they had cardiogenic shock and/or STEMI on admission, received mechanical circulatory support and PCI on different days, required emergent procedures, had multiple mechanical circulatory support devices used, or received coronary artery bypass grafting surgery within the same admission. Variable rate propensity score matching was conducted with 87 preprocedural variables including patient demographic characteristics, comorbidities, prior procedures, prior complications, and provider/hospital factors. The primary end point was the 90-day mortality, and secondary end points included major adverse cardiac and cerebrovascular events (defined as death, myocardial infarction, or stroke), new cardiogenic shock, 30-day acute kidney injury, in-hospital blood transfusions, length of stay, and discharge disposition.
Results
A total of 2416 patients who underwent PVAD-assisted HRPCI and 847 patients who underwent IABP-assisted HRPCI (mean age, 72 ± 10.4 years; 66% women; 19% non-White) were matched with good balance among all matched variables. Compared with those who received IABP support, those who received PVAD support had lower 90-day mortality (7.9% vs 11.8%; P = .01), lower 90-day major adverse cardiac and cerebrovascular events (10.3% vs 14.9%; P < .001), less postprocedural cardiogenic shock (9.5% vs 23.5%; P < .001), and less acute kidney injury (9.9% vs 15.6%; P < .001). PVAD-supported patients had shorter mean lengths of stay (4.3 vs 5.7 days; P < .001) and were more likely to be discharged to home. There were no significant differences in rates of blood transfusions (11.3% vs 10.3%; P = .43) or vascular complications between groups.
Conclusions
This retrospective observational study suggests that PVAD-supported HRPCI in nonshock patients may be associated with improved clinical outcomes compared with IABP-supported HRPCI; however, future randomized trials are required to confirm this finding.
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