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Safety and Efficacy of Percutaneous Ventricular Assist Device vs Intra-Aortic Balloon Pump in Elective High-Risk Percutaneous Coronary Intervention Procedures 选择性高危经皮冠状动脉介入手术中经皮心室辅助装置与主动脉内球囊泵的安全性和有效性
Pub Date : 2025-12-01 DOI: 10.1016/j.jscai.2025.103997
Tayyab Shah MD , Chantal Holy MSc, PhD , Ali Almedhychy MD , Jeffrey W. Moses MD , Helen Parise ScD , Alejandro Lemor MD , William W. O’Neill MD , Alexandra J. Lansky MD

Background

This study compares outcomes between percutaneous ventricular assist device (PVAD)-supported and intra-aortic balloon pump (IABP)-supported high-risk percutaneous coronary intervention (HRPCI) in a large-scale, contemporary hospital administrative dataset.

Methods

Patients undergoing HRPCI supported by PVAD or IABP between January 1, 2018, and April 30, 2024, were identified in the Premier Healthcare Database. Patients were excluded if they had cardiogenic shock and/or STEMI on admission, received mechanical circulatory support and PCI on different days, required emergent procedures, had multiple mechanical circulatory support devices used, or received coronary artery bypass grafting surgery within the same admission. Variable rate propensity score matching was conducted with 87 preprocedural variables including patient demographic characteristics, comorbidities, prior procedures, prior complications, and provider/hospital factors. The primary end point was the 90-day mortality, and secondary end points included major adverse cardiac and cerebrovascular events (defined as death, myocardial infarction, or stroke), new cardiogenic shock, 30-day acute kidney injury, in-hospital blood transfusions, length of stay, and discharge disposition.

Results

A total of 2416 patients who underwent PVAD-assisted HRPCI and 847 patients who underwent IABP-assisted HRPCI (mean age, 72 ± 10.4 years; 66% women; 19% non-White) were matched with good balance among all matched variables. Compared with those who received IABP support, those who received PVAD support had lower 90-day mortality (7.9% vs 11.8%; P = .01), lower 90-day major adverse cardiac and cerebrovascular events (10.3% vs 14.9%; P < .001), less postprocedural cardiogenic shock (9.5% vs 23.5%; P < .001), and less acute kidney injury (9.9% vs 15.6%; P < .001). PVAD-supported patients had shorter mean lengths of stay (4.3 vs 5.7 days; P < .001) and were more likely to be discharged to home. There were no significant differences in rates of blood transfusions (11.3% vs 10.3%; P = .43) or vascular complications between groups.

Conclusions

This retrospective observational study suggests that PVAD-supported HRPCI in nonshock patients may be associated with improved clinical outcomes compared with IABP-supported HRPCI; however, future randomized trials are required to confirm this finding.
本研究比较了当代大型医院管理数据集中经皮心室辅助装置(PVAD)支持和主动脉内球囊泵(IABP)支持的高危经皮冠状动脉介入治疗(HRPCI)的结果。方法2018年1月1日至2024年4月30日期间接受PVAD或IABP支持的HRPCI患者在Premier Healthcare数据库中进行识别。如果患者在入院时发生心源性休克和/或STEMI,在不同日期接受机械循环支持和PCI,需要紧急手术,使用多种机械循环支持装置,或在同一入院期间接受冠状动脉搭桥术,则排除患者。对87个术前变量进行可变率倾向评分匹配,包括患者人口统计学特征、合并症、既往手术、既往并发症和提供者/医院因素。主要终点是90天死亡率,次要终点包括主要的心脑血管不良事件(定义为死亡、心肌梗死或中风)、新的心源性休克、30天急性肾损伤、院内输血、住院时间和出院处置。结果共匹配2416例pvad辅助HRPCI患者和847例iabp辅助HRPCI患者(平均年龄72±10.4岁,女性66%,非白人19%),各匹配变量间平衡良好。与接受IABP支持的患者相比,接受PVAD支持的患者90天死亡率较低(7.9% vs 11.8%; P = 0.01), 90天主要心脑血管不良事件较低(10.3% vs 14.9%; P < 0.001),术后心源性休克较少(9.5% vs 23.5%; P < 0.001),急性肾损伤较少(9.9% vs 15.6%; P < 0.001)。支持pad的患者平均住院时间较短(4.3天vs 5.7天;P < .001),出院回家的可能性更大。两组患者输血率(11.3% vs 10.3%; P = 0.43)和血管并发症发生率无显著差异。结论:这项回顾性观察性研究表明,与iabp支持的HRPCI相比,pad支持的非休克患者HRPCI可能与改善的临床结果相关;然而,需要未来的随机试验来证实这一发现。
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引用次数: 0
Respiratory Support and Mortality Risk Across the Spectrum of Cardiogenic Shock Severity 心源性休克严重程度的呼吸支持和死亡率风险
Pub Date : 2025-12-01 DOI: 10.1016/j.jscai.2025.104043
Talal El Zarif MD , Cesar Caraballo MD , Angela M. Victoria-Castro MD , Israel Safiriyu MD , Maria Gabriela Gastanadui MD , David M. Dudzinski MD , Balimkiz Senman MD , Carlos Alviar MD , Guido Tavazzi MD , Andrea Elliott MD , Aniket S. Rali MD , Mark Jacobs MD , Jason N. Katz MD, MHS , Ann Gage MD , P. Elliott Miller MD, MHS

Background

The Society for Cardiovascular Angiography & Intervention (SCAI) SHOCK stages classification schema risk-stratifies patients with cardiogenic shock (CS). The updated 2022 SCAI SHOCK stages removed the use of respiratory support, either noninvasive (NIV) or invasive mechanical ventilation (IMV), as a criterion. We sought to investigate the impact of receiving respiratory support on in-hospital mortality for patients with CS stratified by SCAI SHOCK stages.

Methods

Utilizing a nationally representative database, adults aged ≥18 years admitted from 2015 to 2023 with a diagnosis of CS were used to assess for the association between respiratory support, either NIV or IMV, on the first day of admission, with in-hospital mortality stratified by SCAI SHOCK stages B through E. We utilized inverse probability treatment weighting, adjusting for demographic characteristics, comorbidities, hospital characteristics, and vasoactive/mechanical circulatory support.

Results

We identified 317,325 patients with CS, including 2.4%, 39.0%, 34.2%, and 24.5% with SCAI stages B through E, respectively. Respiratory support was utilized in 38.0% (n = 120,594) of patients, with 5.4% receiving NIV, 33.8% receiving IMV, and 1.1% receiving both on the first day of admission. After inverse probability treatment weighting, respiratory support use remained associated with an increased mortality overall (weighted mean mortality increase of 18.3%; 95% CI, 17.9%-18.7%), when stratified by each SCAI SHOCK stage and in several key sensitivity analyses.

Conclusions

Compared with patients not receiving respiratory support, the use of respiratory support was associated with an increased mortality for each SCAI stage of CS and could be a simple, easily identifiable CS risk modifier.
心血管血管造影和干预学会(SCAI)休克分期分类方案对心源性休克(CS)患者进行风险分层。更新后的2022 SCAI SHOCK分期不再使用呼吸支持作为标准,无论是无创(NIV)还是有创机械通气(IMV)。我们试图调查接受呼吸支持对按SCAI休克分期分层的CS患者住院死亡率的影响。方法利用具有全国代表性的数据库,选取2015年至2023年收治的年龄≥18岁、诊断为CS的成年人,评估入院第一天呼吸支持(NIV或IMV)与SCAI SHOCK分期B至e分层的住院死亡率之间的关系。我们使用反概率治疗加权,调整人口统计学特征、合并症、医院特征、血管活性/机械循环支持。结果我们确定了317,325例CS患者,其中SCAI B至E期分别为2.4%、39.0%、34.2%和24.5%。38.0% (n = 120,594)的患者使用了呼吸支持,其中5.4%的患者使用了NIV, 33.8%的患者使用了IMV, 1.1%的患者在入院第一天使用了两者。在反概率治疗加权后,呼吸支持的使用仍然与总体死亡率增加相关(加权平均死亡率增加18.3%;95% CI, 17.9%-18.7%),当按每个SCAI休克阶段分层和几个关键敏感性分析时。结论与未接受呼吸支持的患者相比,使用呼吸支持与SCAI CS各阶段死亡率增加相关,可能是一个简单,易于识别的CS风险调节剂。
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引用次数: 0
Comparative Effectiveness of Balloon Aortic Valvuloplasty via Transradial and Transfemoral Access 经桡动脉与经股动脉球囊主动脉瓣成形术的疗效比较
Pub Date : 2025-12-01 DOI: 10.1016/j.jscai.2025.104015
Jonathan X. Fang MBBS , Pedro A. Villablanca MD , Tiberio M. Frisoli MD , Pedro Engel Gonzalez MD , James C. Lee MD , Georgi K. Fram MD , Leo Kar Lok Lai MBChB , Gennaro Giustino MD , Hussayn Alrayes DO , Louie B. Kamel-Abusalha BS , Rama Ellauzi MD , Samuel Gregerson MD , Michael Chiang MBBS , Kent Chak-yu So MBChB , Dee Dee Wang MD , William W. O’Neill MD , Brian P. O’Neill MD

Background

Balloon aortic valvuloplasty (BAV) is commonly performed as a bridge to therapy, for stratification, or as a palliative procedure in cases of severe aortic stenosis. The complication rate of transfemoral access BAV (transfemoral valvuloplasty [TFV]) is comparable to that of transcatheter aortic valve replacement. Transradial access BAV (transradial valvuloplasty [TRV]) is technically feasible; however, comparative data for TFV are lacking. We aim to compare TFV and TRV in terms of technical and hemodynamic success, periprocedural safety, and short-term clinical outcomes.

Methods

Consecutive patients undergoing BAV at a tertiary center from 2021 to 2024 were assessed. TRV was performed with ultrasound guidance and an 8F short sheath equipped with compatible balloons. Hemodynamic success was defined as a reduction in gradient of 30% or more. The primary outcome was the periprocedural composite of a Valve Academic Research Consortium (VARC) 3 major vascular complication, grade 3 to 4 bleeding, and balloon entrapment, and nonaccess-related events, including complete heart block, periprocedural stroke, hypotension, severe aortic insufficiency, and periprocedural death. The secondary outcome was the 30-day composite of all-cause mortality, cardiac-related hospitalization, and discharge failure. Inverse probability of treatment weighting, followed by multivariate regression, was employed to address confounders.

Results

105 TRV and 148 TFV were included. Technical success rate was 96.2% for TRV and 98.7% for TFV (P = .21). The primary outcome event rate was significantly lower in the TRV compared to the TFV group: 2.53% vs 17.47%; adjusted odds ratio, 0.13; 95% CI, 0.04-0.49; P = .003. Technical and hemodynamic success and secondary outcomes were comparable between TRV and TFV.

Conclusions

In comparison to TFV, TRV is associated with lower rates of periprocedural safety events while maintaining similar short-term clinical outcomes and hemodynamic performance.
背景:主动脉瓣球囊成形术(BAV)通常作为治疗的桥梁,用于分层,或作为严重主动脉狭窄病例的姑息性手术。经股通道BAV(经股瓣膜成形术[TFV])的并发症发生率与经导管主动脉瓣置换术相当。经桡骨入路BAV(经桡骨瓣膜成形术)在技术上是可行的;然而,缺乏ttfv的比较数据。我们的目的是比较TFV和TRV在技术和血流动力学方面的成功,围手术期安全性和短期临床结果。方法对2021 - 2024年在某三级中心连续接受BAV治疗的患者进行评估。TRV是在超声引导下进行的,8F短护套装有兼容的气球。血流动力学的成功定义为梯度降低30%或更多。主要终点是瓣膜学术研究协会(VARC) 3级主要血管并发症、3 - 4级出血、球囊夹闭和非通路相关事件(包括完全性心脏传导阻滞、术中卒中、低血压、严重主动脉不全和术中死亡)的围手术期综合结果。次要终点是30天的全因死亡率、心脏相关住院和出院失败的综合结果。采用治疗加权逆概率,然后进行多元回归,以解决混杂因素。结果共纳入TRV 105例,TFV 148例。TRV和TFV的技术成功率分别为96.2%和98.7% (P = 0.21)。与TFV组相比,TRV组的主要结局事件发生率显著降低:2.53% vs 17.47%;调整后优势比为0.13;95% ci, 0.04-0.49;P = 0.003。TRV和TFV的技术和血流动力学成功及次要结果具有可比性。结论与TFV相比,TRV在维持相似的短期临床结果和血流动力学表现的同时,其围手术期安全事件发生率较低。
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引用次数: 0
Impact of Left Ventricular End-Diastolic Pressure on Percutaneous Coronary Intervention Outcomes 左心室舒张末期压对经皮冠状动脉介入治疗结果的影响
Pub Date : 2025-12-01 DOI: 10.1016/j.jscai.2025.104017
Matthew Siano MD , Yash Jobanputra MD , Angelo Oliva MD , Samantha Sartori PhD , Kenneth Smith MPH , Harleen Kaur BA , Joseph Sweeny MD , George D. Dangas MD, PhD , Roxana Mehran MD , Annapoorna S. Kini MD , Samin K. Sharma MD

Background

Left ventricular end-diastolic pressure (LVEDP) is associated with adverse outcomes following percutaneous coronary intervention (PCI) for acute coronary syndrome (ACS). We evaluated the impact of LVEDP on outcomes in patients with chronic coronary syndrome or ACS undergoing PCI.

Methods

Consecutive patients undergoing PCI between 2014 and 2021 were included. Patients with LVEDP ≤14 mm Hg were compared to those with LVEDP 15 to 20 mm Hg and LVEDP >20 mm Hg. The primary outcome was all-cause mortality at 1 year. A supplemental analysis was conducted in patients with LVEDP >20 mm Hg according to left ventricular ejection fraction.

Results

There were significant differences in baseline characteristics between patients with LVEDP ≤14 mm Hg (n = 10,547), LVEDP 15 to 20 mm Hg (n = 5011), and LVEDP >20 mm Hg (n = 1621). Patients with LVEDP >20 mm Hg had the highest prevalence of comorbidities and complexity of coronary artery disease. Compared to patients with LVEDP ≤14 mm Hg, increased all-cause mortality was observed in patients with LVEDP 15 to 20 mm Hg (3.0% vs 1.6%; adjusted hazard ratio [aHR], 1.47; 95% CI, 1.15-1.87; P = .002) and LVEDP >20 mm Hg (7.6% vs 1.6%, aHR, 3.00; 95% CI, 2.31-3.90; P < .001) at 1 year. In patients with LVEDP >20 mm Hg, a left ventricular ejection fraction <40% was associated with increased 1-year all-cause mortality (11.4% vs 2.8%; aHR, 2.71; 95% CI, 1.36-5.37; P = .004).

Conclusions

In a population of patients with chronic coronary syndrome and ACS undergoing PCI, elevated LVEDP was associated with increased mortality at 1 year. Systolic dysfunction was associated with higher mortality in patients with LVEDP >20 mm Hg.
背景:左心室舒张末期压(LVEDP)与急性冠脉综合征(ACS)经皮冠状动脉介入治疗(PCI)后的不良结局相关。我们评估了LVEDP对接受PCI治疗的慢性冠脉综合征或ACS患者预后的影响。方法纳入2014 - 2021年间连续接受PCI治疗的患者。将LVEDP≤14 mm Hg的患者与LVEDP≤15 ~ 20 mm Hg和LVEDP≤20 mm Hg的患者进行比较。主要终点为1年全因死亡率。根据左室射血分数对LVEDP >;20 mm Hg患者进行补充分析。结果LVEDP≤14 mm Hg (n = 10,547)、LVEDP 15 ~ 20 mm Hg (n = 5011)和LVEDP >;20 mm Hg (n = 1621)患者的基线特征有显著差异。LVEDP = 20 mm Hg的患者冠状动脉疾病的合并症患病率和复杂性最高。与LVEDP≤14 mm Hg的患者相比,LVEDP≤15至20 mm Hg的患者1年全因死亡率增加(3.0% vs 1.6%;校正危险比[aHR], 1.47; 95% CI, 1.15-1.87; P = 0.002)和LVEDP≤20 mm Hg的患者(7.6% vs 1.6%, aHR, 3.00; 95% CI, 2.31-3.90; P < 0.001)。在LVEDP≤20mm Hg的患者中,左室射血分数≥40%与1年全因死亡率增加相关(11.4% vs 2.8%; aHR, 2.71; 95% CI, 1.36-5.37; P = 0.004)。结论在接受PCI治疗的慢性冠脉综合征和ACS患者中,LVEDP升高与1年死亡率增加相关。20 mm Hg LVEDP患者的收缩功能障碍与较高的死亡率相关。
{"title":"Impact of Left Ventricular End-Diastolic Pressure on Percutaneous Coronary Intervention Outcomes","authors":"Matthew Siano MD ,&nbsp;Yash Jobanputra MD ,&nbsp;Angelo Oliva MD ,&nbsp;Samantha Sartori PhD ,&nbsp;Kenneth Smith MPH ,&nbsp;Harleen Kaur BA ,&nbsp;Joseph Sweeny MD ,&nbsp;George D. Dangas MD, PhD ,&nbsp;Roxana Mehran MD ,&nbsp;Annapoorna S. Kini MD ,&nbsp;Samin K. Sharma MD","doi":"10.1016/j.jscai.2025.104017","DOIUrl":"10.1016/j.jscai.2025.104017","url":null,"abstract":"<div><h3>Background</h3><div>Left ventricular end-diastolic pressure (LVEDP) is associated with adverse outcomes following percutaneous coronary intervention (PCI) for acute coronary syndrome (ACS). We evaluated the impact of LVEDP on outcomes in patients with chronic coronary syndrome or ACS undergoing PCI.</div></div><div><h3>Methods</h3><div>Consecutive patients undergoing PCI between 2014 and 2021 were included. Patients with LVEDP ≤14 mm Hg were compared to those with LVEDP 15 to 20 mm Hg and LVEDP &gt;20 mm Hg. The primary outcome was all-cause mortality at 1 year. A supplemental analysis was conducted in patients with LVEDP &gt;20 mm Hg according to left ventricular ejection fraction.</div></div><div><h3>Results</h3><div>There were significant differences in baseline characteristics between patients with LVEDP ≤14 mm Hg (n = 10,547), LVEDP 15 to 20 mm Hg (n = 5011), and LVEDP &gt;20 mm Hg (n = 1621). Patients with LVEDP &gt;20 mm Hg had the highest prevalence of comorbidities and complexity of coronary artery disease. Compared to patients with LVEDP ≤14 mm Hg, increased all-cause mortality was observed in patients with LVEDP 15 to 20 mm Hg (3.0% vs 1.6%; adjusted hazard ratio [aHR], 1.47; 95% CI, 1.15-1.87; <em>P</em> = .002) and LVEDP &gt;20 mm Hg (7.6% vs 1.6%, aHR, 3.00; 95% CI, 2.31-3.90; <em>P</em> &lt; .001) at 1 year. In patients with LVEDP &gt;20 mm Hg, a left ventricular ejection fraction &lt;40% was associated with increased 1-year all-cause mortality (11.4% vs 2.8%; aHR, 2.71; 95% CI, 1.36-5.37; <em>P</em> = .004).</div></div><div><h3>Conclusions</h3><div>In a population of patients with chronic coronary syndrome and ACS undergoing PCI, elevated LVEDP was associated with increased mortality at 1 year. Systolic dysfunction was associated with higher mortality in patients with LVEDP &gt;20 mm Hg.</div></div>","PeriodicalId":73990,"journal":{"name":"Journal of the Society for Cardiovascular Angiography & Interventions","volume":"4 12","pages":"Article 104017"},"PeriodicalIF":0.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145754176","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Outcomes After Transcatheter Mitral Valve Replacement in Valve in Valve, Valve in Ring, and Mitral Annular Calcification 经导管二尖瓣置换术后二尖瓣内瓣、瓣内环和二尖瓣环钙化的结果
Pub Date : 2025-12-01 DOI: 10.1016/j.jscai.2025.104003
Chikashi Nakai MD , Augustin DeLago MD , Sanjay Samy MD

Background

There are few reports about midterm to long-term outcomes of transcatheter mitral valve replacement (TMVR) in valve in valve (ViV), valve in ring (ViR), and valve in mitral annular calcification (ViM). The aim of this study was to assess postoperative outcomes in patients who underwent TMVR for calcification or failing valves.

Methods

Between March 2016 and July 2024, 82 patients underwent TMVR with SAPIEN 3 (Edwards Lifescience) balloon-expandable valve, with 72 transseptal and 10 transapical access. Of 82 patients, 47 had TMVR with ViV/ViR and 35 with ViM. Postprocedural outcomes and midterm survivals were evaluated comparing ViV/ViR group with ViM group.

Results

The ViM required more ventricular septal ablation before TMVR for left ventricular outflow tract obstruction (31.4% [11/35] vs 4.3% [2/47]; P < .01). Early hospital mortality was significantly higher in the ViM group (34.5% [12/35] vs 2.1% [1/47]; P < .01). The incidence of postprocedural stroke, left ventricular outflow tract obstruction, permanent pacemaker, and reintervention for mitral valve was similar between the 2 groups. The mean follow-up term was 17.6 ± 22.5 months. The cumulative 5-year survivals in ViV/ViR and ViM were 57.4% and 24.3%, respectively. A significant difference was noted in the midterm outcome between the 2 groups (P < .01). On multivariable Cox proportional hazards analysis, only conducting ViM procedure was associated with an increased midterm mortality (hazard ratio, 2.58; 95% CI, 1.33-4.99; P < .01).

Conclusions

Short-term and midterm outcomes of TMVR in ViV and ViR were better than those of ViM in this patient cohort.
关于经导管二尖瓣置换术(TMVR)中瓣内瓣(ViV)、瓣内环(ViR)和瓣内二尖瓣环钙化(ViM)的中期到长期结果的报道很少。本研究的目的是评估因钙化或瓣膜衰竭而接受TMVR的患者的术后结果。方法2016年3月至2024年7月,82例患者采用SAPIEN 3 (Edwards Lifescience)球囊扩张瓣膜行TMVR,其中72例经隔膜,10例经根尖。在82例患者中,47例TMVR合并ViV/ViR, 35例合并ViM。比较ViV/ViR组和ViM组的术后预后和中期生存率。结果左室流出道梗阻的ViM患者在TMVR前需要更多的室间隔消融(31.4% [11/35]vs 4.3% [2/47]; P < .01)。ViM组早期住院死亡率显著高于对照组(34.5% [12/35]vs 2.1% [1/47]; P < 0.01)。术后卒中、左室流出道梗阻、永久性起搏器、二尖瓣再干预的发生率在两组之间相似。平均随访时间为17.6±22.5个月。ViV/ViR和ViM的累积5年生存率分别为57.4%和24.3%。两组中期预后差异有统计学意义(P < 0.01)。在多变量Cox比例风险分析中,仅进行ViM手术与中期死亡率增加相关(风险比2.58;95% CI, 1.33-4.99; P < 0.01)。结论在该患者队列中,TMVR在ViV和ViR组的短期和中期预后优于ViM组。
{"title":"Outcomes After Transcatheter Mitral Valve Replacement in Valve in Valve, Valve in Ring, and Mitral Annular Calcification","authors":"Chikashi Nakai MD ,&nbsp;Augustin DeLago MD ,&nbsp;Sanjay Samy MD","doi":"10.1016/j.jscai.2025.104003","DOIUrl":"10.1016/j.jscai.2025.104003","url":null,"abstract":"<div><h3>Background</h3><div>There are few reports about midterm to long-term outcomes of transcatheter mitral valve replacement (TMVR) in valve in valve (ViV), valve in ring (ViR), and valve in mitral annular calcification (ViM). The aim of this study was to assess postoperative outcomes in patients who underwent TMVR for calcification or failing valves.</div></div><div><h3>Methods</h3><div>Between March 2016 and July 2024, 82 patients underwent TMVR with SAPIEN 3 (Edwards Lifescience) balloon-expandable valve, with 72 transseptal and 10 transapical access. Of 82 patients, 47 had TMVR with ViV/ViR and 35 with ViM. Postprocedural outcomes and midterm survivals were evaluated comparing ViV/ViR group with ViM group.</div></div><div><h3>Results</h3><div>The ViM required more ventricular septal ablation before TMVR for left ventricular outflow tract obstruction (31.4% [11/35] vs 4.3% [2/47]; <em>P</em> &lt; .01). Early hospital mortality was significantly higher in the ViM group (34.5% [12/35] vs 2.1% [1/47]; <em>P</em> &lt; .01). The incidence of postprocedural stroke, left ventricular outflow tract obstruction, permanent pacemaker, and reintervention for mitral valve was similar between the 2 groups. The mean follow-up term was 17.6 ± 22.5 months. The cumulative 5-year survivals in ViV/ViR and ViM were 57.4% and 24.3%, respectively. A significant difference was noted in the midterm outcome between the 2 groups (<em>P</em> &lt; .01). On multivariable Cox proportional hazards analysis, only conducting ViM procedure was associated with an increased midterm mortality (hazard ratio, 2.58; 95% CI, 1.33-4.99; <em>P</em> &lt; .01).</div></div><div><h3>Conclusions</h3><div>Short-term and midterm outcomes of TMVR in ViV and ViR were better than those of ViM in this patient cohort.</div></div>","PeriodicalId":73990,"journal":{"name":"Journal of the Society for Cardiovascular Angiography & Interventions","volume":"4 12","pages":"Article 104003"},"PeriodicalIF":0.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145754215","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Pitfalls in Comparing Mechanical Circulatory Support Devices Using Administrative Datasets: Epidemiology of the Diseased Population 使用管理数据集比较机械循环支持装置的缺陷:患病人群的流行病学
Pub Date : 2025-12-01 DOI: 10.1016/j.jscai.2025.103998
Tayyab Shah MD , Chantal Holy MSc, PhD , Ali Almedhychy MD , Jeffrey W. Moses MD , Helen Parise ScD , Alejandro Lemor MD , William W. O’Neill MD , Alexandra J. Lansky MD
{"title":"Pitfalls in Comparing Mechanical Circulatory Support Devices Using Administrative Datasets: Epidemiology of the Diseased Population","authors":"Tayyab Shah MD ,&nbsp;Chantal Holy MSc, PhD ,&nbsp;Ali Almedhychy MD ,&nbsp;Jeffrey W. Moses MD ,&nbsp;Helen Parise ScD ,&nbsp;Alejandro Lemor MD ,&nbsp;William W. O’Neill MD ,&nbsp;Alexandra J. Lansky MD","doi":"10.1016/j.jscai.2025.103998","DOIUrl":"10.1016/j.jscai.2025.103998","url":null,"abstract":"","PeriodicalId":73990,"journal":{"name":"Journal of the Society for Cardiovascular Angiography & Interventions","volume":"4 12","pages":"Article 103998"},"PeriodicalIF":0.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145754172","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
SCAI Position Statement on Intracardiac Echocardiography to Guide Structural Heart Disease Interventions SCAI对心脏内超声心动图指导结构性心脏病干预的立场声明
Pub Date : 2025-12-01 DOI: 10.1016/j.jscai.2025.103946
Mackram F. Eleid MD, FSCAI , Christine J. Chung MD , Matthew J. Daniels MD, PhD, FSCAI , V. Vivian Dimas MD, FSCAI , Andrew M. Goldsweig MD, MSc, FSCAI , Harsh Golwala MD, FSCAI , Eric M. Horlick MDCM, FRCPC, MSCAI , Matthew J. Price MD, FSCAI , Carlos E. Sanchez MD, FSCAI , John T. Saxon MD, FSCAI , Markus D. Scherer MD, FSCAI , Gilbert H.L. Tang MD, MBA, FSCAI , Dee Dee Wang MD, FSCAI , Omar K. Khalique MD, FSCAI
As structural heart disease interventions rapidly evolve, demand for minimally invasive intraprocedural imaging techniques has increased. Intracardiac echocardiography (ICE) has emerged as a valuable imaging modality, offering real-time, high-resolution visualization of cardiac structures without the need for general anesthesia. This position statement from the Society for Cardiovascular Angiography & Interventions outlines the clinical applications, advantages, limitations, and implementation strategies for ICE in guiding transcatheter structural heart disease procedures. The document details standardized ICE imaging protocols and views for interventions involving the mitral, tricuspid, and pulmonary valves, as well as left atrial appendage occlusion atrial septal defect, and patent foramen ovale closure. It emphasizes the importance of operator training, physician workflows, and institutional readiness for successful ICE integration. The statement also advocates for updated reimbursement models that reflect the complexity and value of ICE-guided procedures and calls for further research comparing ICE and transesophageal echocardiography outcomes.
随着结构性心脏病干预措施的迅速发展,对微创术中成像技术的需求也在增加。心内超声心动图(ICE)已成为一种有价值的成像方式,无需全身麻醉即可提供实时、高分辨率的心脏结构可视化。心血管血管造影与干预学会的立场声明概述了ICE在指导经导管结构性心脏病手术中的临床应用、优势、局限性和实施策略。该文件详细介绍了标准化的ICE成像方案和涉及二尖瓣、三尖瓣和肺动脉瓣、左房耳闭塞、房间隔缺损和卵圆孔未闭的干预视图。它强调了操作员培训、医生工作流程和机构准备对成功整合ICE的重要性。该声明还主张更新报销模式,以反映ICE指导程序的复杂性和价值,并呼吁进一步研究比较ICE和经食管超声心动图结果。
{"title":"SCAI Position Statement on Intracardiac Echocardiography to Guide Structural Heart Disease Interventions","authors":"Mackram F. Eleid MD, FSCAI ,&nbsp;Christine J. Chung MD ,&nbsp;Matthew J. Daniels MD, PhD, FSCAI ,&nbsp;V. Vivian Dimas MD, FSCAI ,&nbsp;Andrew M. Goldsweig MD, MSc, FSCAI ,&nbsp;Harsh Golwala MD, FSCAI ,&nbsp;Eric M. Horlick MDCM, FRCPC, MSCAI ,&nbsp;Matthew J. Price MD, FSCAI ,&nbsp;Carlos E. Sanchez MD, FSCAI ,&nbsp;John T. Saxon MD, FSCAI ,&nbsp;Markus D. Scherer MD, FSCAI ,&nbsp;Gilbert H.L. Tang MD, MBA, FSCAI ,&nbsp;Dee Dee Wang MD, FSCAI ,&nbsp;Omar K. Khalique MD, FSCAI","doi":"10.1016/j.jscai.2025.103946","DOIUrl":"10.1016/j.jscai.2025.103946","url":null,"abstract":"<div><div>As structural heart disease interventions rapidly evolve, demand for minimally invasive intraprocedural imaging techniques has increased. Intracardiac echocardiography (ICE) has emerged as a valuable imaging modality, offering real-time, high-resolution visualization of cardiac structures without the need for general anesthesia. This position statement from the Society for Cardiovascular Angiography &amp; Interventions outlines the clinical applications, advantages, limitations, and implementation strategies for ICE in guiding transcatheter structural heart disease procedures. The document details standardized ICE imaging protocols and views for interventions involving the mitral, tricuspid, and pulmonary valves, as well as left atrial appendage occlusion atrial septal defect, and patent foramen ovale closure. It emphasizes the importance of operator training, physician workflows, and institutional readiness for successful ICE integration. The statement also advocates for updated reimbursement models that reflect the complexity and value of ICE-guided procedures and calls for further research comparing ICE and transesophageal echocardiography outcomes.</div></div>","PeriodicalId":73990,"journal":{"name":"Journal of the Society for Cardiovascular Angiography & Interventions","volume":"4 12","pages":"Article 103946"},"PeriodicalIF":0.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145754098","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Protamine Utilization and Clinical Outcomes for Coronary Artery Perforation in Chronic Total Occlusion Percutaneous Coronary Intervention Procedures 慢性全闭塞经皮冠状动脉介入治疗中冠状动脉穿孔的鱼精蛋白使用和临床结果
Pub Date : 2025-12-01 DOI: 10.1016/j.jscai.2025.104000
Akash Kataruka MD , Kanwar Parhar BS , David Daniels MD , Charles Maynard PhD , Kathleen E. Kearney MD , Ahmed Mahmoud MD , Jacob A. Doll MD , James M. McCabe MD , William L. Lombardi MD , Ravi S. Hira MD

Background

Limited evidence exists for the management of coronary artery perforation. We evaluated temporal trends and clinical outcomes associated with protamine use following coronary artery perforation in patients undergoing percutaneous coronary intervention (PCI) for chronic total occlusions (CTOs).

Methods

A single-center retrospective analysis was performed on coronary perforations in patients undergoing CTO PCI procedures between September 10, 2014, and December 31, 2018, encompassing a change in institutional practice regarding use of protamine at case conclusion. The primary outcome was a composite of in-hospital mortality and cardiac tamponade. Multivariate logistic regression analyses were used to assess the association between protamine use and clinical outcomes.

Results

In total, 1454 patients undergoing CTO PCI, coronary perforation occurred in 160 (11.0%), of which 68 (42.5%) received protamine. Ellis perforation classification was similar in the protamine and non-protamine groups (P = .148). The primary outcome of in-hospital mortality or cardiac tamponade occurred less frequently in the protamine group compared with the nonprotamine group (11.8% vs 40.2%; P < .01). In-hospital mortality (1.5% vs 14.1%; P = .01) and cardiac tamponade (10.3% vs 26.1%; P = .02) occurred less frequently in the protamine group. In a multivariate logistic regression, protamine was independently associated with an improved primary outcome (OR, 0.27; 95% CI, 0.10-0.65; P < .01).

Conclusions

In this retrospective analysis, use of protamine in patients with coronary artery perforation complicating CTO PCI was associated with a reduction in death and cardiac tamponade without evidence of increased stent thrombosis. Additional studies are warranted to establish optimal strategies for protamine use.
背景:关于冠状动脉穿孔治疗的证据有限。我们评估了经皮冠状动脉介入治疗慢性全闭塞(CTOs)患者冠状动脉穿孔后鱼精蛋白使用的时间趋势和临床结果。方法对2014年9月10日至2018年12月31日期间接受CTO PCI手术的患者冠状动脉穿孔进行单中心回顾性分析,包括在病例结束时使用鱼精蛋白的机构实践变化。主要结局是住院死亡率和心脏填塞的综合结果。多变量logistic回归分析用于评估鱼精蛋白使用与临床结果之间的关系。结果1454例CTO PCI患者中,发生冠状动脉穿孔160例(11.0%),其中鱼精蛋白68例(42.5%)。鱼精蛋白组和非鱼精蛋白组的Ellis穿孔分类相似(P = .148)。与非鱼精蛋白组相比,鱼精蛋白组住院死亡率或心脏填塞的主要结局发生率较低(11.8% vs 40.2%; P < 0.01)。鱼精蛋白组的住院死亡率(1.5% vs 14.1%, P = 0.01)和心包填塞(10.3% vs 26.1%, P = 0.02)发生率较低。在多因素logistic回归中,鱼精蛋白与改善的主要预后独立相关(OR, 0.27; 95% CI, 0.10-0.65; P < 0.01)。结论:在这项回顾性分析中,在冠状动脉穿孔合并CTO PCI患者中使用鱼精蛋白与死亡率和心包填塞的降低相关,且无支架血栓形成增加的证据。需要进一步的研究来确定鱼精蛋白使用的最佳策略。
{"title":"Protamine Utilization and Clinical Outcomes for Coronary Artery Perforation in Chronic Total Occlusion Percutaneous Coronary Intervention Procedures","authors":"Akash Kataruka MD ,&nbsp;Kanwar Parhar BS ,&nbsp;David Daniels MD ,&nbsp;Charles Maynard PhD ,&nbsp;Kathleen E. Kearney MD ,&nbsp;Ahmed Mahmoud MD ,&nbsp;Jacob A. Doll MD ,&nbsp;James M. McCabe MD ,&nbsp;William L. Lombardi MD ,&nbsp;Ravi S. Hira MD","doi":"10.1016/j.jscai.2025.104000","DOIUrl":"10.1016/j.jscai.2025.104000","url":null,"abstract":"<div><h3>Background</h3><div>Limited evidence exists for the management of coronary artery perforation. We evaluated temporal trends and clinical outcomes associated with protamine use following coronary artery perforation in patients undergoing percutaneous coronary intervention (PCI) for chronic total occlusions (CTOs).</div></div><div><h3>Methods</h3><div>A single-center retrospective analysis was performed on coronary perforations in patients undergoing CTO PCI procedures between September 10, 2014, and December 31, 2018, encompassing a change in institutional practice regarding use of protamine at case conclusion. The primary outcome was a composite of in-hospital mortality and cardiac tamponade. Multivariate logistic regression analyses were used to assess the association between protamine use and clinical outcomes.</div></div><div><h3>Results</h3><div>In total, 1454 patients undergoing CTO PCI, coronary perforation occurred in 160 (11.0%), of which 68 (42.5%) received protamine. Ellis perforation classification was similar in the protamine and non-protamine groups (<em>P</em> = .148). The primary outcome of in-hospital mortality or cardiac tamponade occurred less frequently in the protamine group compared with the nonprotamine group (11.8% vs 40.2%; <em>P</em> &lt; .01). In-hospital mortality (1.5% vs 14.1%; <em>P</em> = .01) and cardiac tamponade (10.3% vs 26.1%; <em>P</em> = .02) occurred less frequently in the protamine group. In a multivariate logistic regression, protamine was independently associated with an improved primary outcome (OR, 0.27; 95% CI, 0.10-0.65; <em>P</em> &lt; .01).</div></div><div><h3>Conclusions</h3><div>In this retrospective analysis, use of protamine in patients with coronary artery perforation complicating CTO PCI was associated with a reduction in death and cardiac tamponade without evidence of increased stent thrombosis. Additional studies are warranted to establish optimal strategies for protamine use.</div></div>","PeriodicalId":73990,"journal":{"name":"Journal of the Society for Cardiovascular Angiography & Interventions","volume":"4 12","pages":"Article 104000"},"PeriodicalIF":0.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145754212","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
From Mild Discomfort to Myopericarditis—A Complication of Patent Foramen Ovale Occluder Device Placement: A Case Report 从轻微不适到心包膜炎——卵圆孔未闭封堵器置入的并发症1例
Pub Date : 2025-12-01 DOI: 10.1016/j.jscai.2025.104044
Anastasia Proshkina MD , Jonathan Shpigelman MD , Rami Al Ayyubi MD , Mohamad Bahrou MD , Ra’ad Al Tamimi MD , Ahmad Al Turk MD
A 43-year-old woman underwent successful elective closure of a large aneurysmal patent foramen ovale (PFO) using a GORE CARDIOFORM Septal Occluder. She experienced mild chest discomfort immediately postprocedure but was discharged after a transthoracic echocardiogram confirmed appropriate device positioning and no acute abnormalities. She returned the following day with worsening pleuritic chest pain unresponsive to acetaminophen and ibuprofen. Her clinical presentation, together with her electrocardiogram, laboratory, and imaging findings, was diagnostic of myopericarditis. She was treated with colchicine and ibuprofen, resulting in complete symptom resolution. This case illustrates a rare complication of PFO closure, potentially related to nickel hypersensitivity. Currently, no validated tools exist to predict such hypersensitivity reactions, and nickel-free PFO closure devices are not commercially available. Until alternatives become available, clinicians must balance the risk of hypersensitivity reactions against the proven benefit of PFO closure in preventing recurrent stroke in select patients.
一名43岁的女性使用GORE CARDIOFORM室间隔封堵器成功地选择性关闭了大动脉瘤性卵圆孔未闭(PFO)。她术后立即感到轻微的胸部不适,但经胸超声心动图确认装置位置合适且无急性异常后出院。第二天再次就诊时胸膜炎性胸痛加重,对扑热息痛和布洛芬无反应。她的临床表现,连同她的心电图,实验室和影像学结果,诊断为心包炎。给予秋水仙碱和布洛芬治疗,症状完全缓解。本病例显示了PFO闭合的罕见并发症,可能与镍过敏有关。目前,还没有经过验证的工具来预测这种超敏反应,无镍PFO封闭装置也没有商业化。在找到替代方案之前,临床医生必须权衡过敏反应的风险和PFO关闭在预防复发性卒中患者中已证实的益处。
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引用次数: 0
Mechanical Circulatory Support for High-Risk Percutaneous Coronary Intervention: Is It a Choice or Chance That Determines Outcomes? 机械循环支持高危经皮冠状动脉介入治疗:决定结果的是选择还是机会?
Pub Date : 2025-12-01 DOI: 10.1016/j.jscai.2025.104021
Ali O. Malik MD, MSc , Jason R. Wollmuth MD
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引用次数: 0
期刊
Journal of the Society for Cardiovascular Angiography & Interventions
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