JTCVS open最新文献

{"title":"Operative and nonoperative outcomes in patients with trisomy 13 and 18 with congenital heart disease","authors":"","doi":"10.1016/j.xjon.2024.06.007","DOIUrl":"10.1016/j.xjon.2024.06.007","url":null,"abstract":"<div><h3>Objective</h3><p>To evaluate the short- and long-term outcomes of cardiac repair versus nonoperative management in patients with trisomy 13 and trisomy 18 with congenital heart disease.</p></div><div><h3>Methods</h3><p>An institutional review board-approved, retrospective review was undertaken to identify all patients admitted with trisomy 13/18 and congenital heart disease. Patients were divided into 2 cohorts (operated vs nonoperated) and compared.</p></div><div><h3>Results</h3><p>Between 1985 and 2023, 62 patients (34 operated and 28 nonoperated) with trisomy 13 (n = 9) and trisomy 18 (n = 53) were identified. The operated cohort was 74% girls, underwent mainly The Society of Thoracic Surgeons-European Association for Cardio-Thoracic Surgery mortality category 1 procedures (n = 24 [71%]) at a median age of 2.5 months (interquartile range [IQR], 1.3-4.5 months). This compares with the nonoperative cohort where 64% (n = 18) would have undergone The Society of Thoracic Surgeons-European Association for Cardio-Thoracic Surgery mortality category 1 procedures if surgery would have been elected. The most common diagnosis was ventricular septal defect. Postoperative median intensive care unit stay was 6.5 days (IQR, 3.7-15 days) with a total hospital length of stay of 15 days (IQR, 11-49 days). Thirty-day postoperative survival was 94%. There were 5 in-hospital deaths in the operated and 7 in the nonoperated cohort. Median follow-up was 15.4 months (IQR, 4.3-48.7 months) for the operated and 11.2 months (IQR, 1.2-48.3 months) for the nonoperated cohorts. One-year survival was 79% operated versus 51.5% nonoperated (<em>P</em> &lt; .003). Nonoperative treatment had an increased risk of mortality (hazard ratio, 3.28; 95% CI, 1.46-7.4; <em>P</em> = .004).</p></div><div><h3>Conclusions</h3><p>Controversy exists regarding the role of primary cardiac repair in patients with trisomy 13/18 and congenital heart disease. Cardiac repair can be performed safely with low early mortality and operated patients had higher long-term survival compared with nonoperated in our cohort.</p></div>","PeriodicalId":74032,"journal":{"name":"JTCVS open","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666273624001669/pdfft?md5=7f5c6941eee514d471dc97a60d6160e8&pid=1-s2.0-S2666273624001669-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141960995","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Discussion to: Identifying lung cancer disparities among Asian Americans: A novel analytic approach","authors":"","doi":"10.1016/j.xjon.2024.05.001","DOIUrl":"10.1016/j.xjon.2024.05.001","url":null,"abstract":"","PeriodicalId":74032,"journal":{"name":"JTCVS open","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666273624001219/pdfft?md5=1602ca512303ca2f2f94ba095b471d2e&pid=1-s2.0-S2666273624001219-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141055694","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Intramyocardial injection of hypoxia-conditioned extracellular vesicles increases myocardial perfusion in a swine model of chronic coronary disease","authors":"","doi":"10.1016/j.xjon.2024.06.003","DOIUrl":"10.1016/j.xjon.2024.06.003","url":null,"abstract":"<div><h3>Objective</h3><p>Coronary artery disease remains a leading cause of morbidity and mortality worldwide. Patients with advanced coronary artery disease who are not eligible for endovascular or surgical revascularization have limited options. Extracellular vesicles have shown potential to improve myocardial function in preclinical models. Extracellular vesicles can be conditioned to modify their components. Hypoxia-conditioned extracellular vesicles have demonstrated the ability to reduce infarct size and apoptosis in small animals. Our objective is to assess the potential benefits of hypoxia-conditioned extracellular vesicles in a large animal model of coronary artery disease.</p></div><div><h3>Methods</h3><p>Coronary artery disease was induced in 14 Yorkshire swine by ameroid constriction of the left circumflex coronary artery. Two weeks postsurgery, swine underwent a repeat left thoracotomy for injections of hypoxia-conditioned extracellular vesicles (n = 7) or saline (control, n = 7). Five weeks later, all animals underwent terminal harvest for perfusion measurements and myocardial sectioning.</p></div><div><h3>Results</h3><p>Myocardial perfusion analysis demonstrated a trend toward increase at rest and a significant increase during rapid pacing (<em>P =</em> .09, <em>P &lt;</em> .001). There were significant increases in activated phosphorylated endothelial nitric oxide synthase, endothelial nitric oxide synthase, phosphatidylinositol 3-kinase, phosphorylated protein kinase B, and the phosphorylated protein kinase B/protein kinase B ratio in the hypoxia-conditioned extracellular vesicles group compared with the control group (all <em>P</em> &lt; .05). Additionally, there was a significant decrease in the antiangiogenic proteins collagen 18 and angiostatin (<em>P =</em> .01, <em>P</em> = .01) in the hypoxia-conditioned extracellular vesicles group.</p></div><div><h3>Conclusions</h3><p>Intramyocardial injection of hypoxia-conditioned extracellular vesicles results in increased myocardial perfusion without a corresponding change in vessel density. Therefore, this improvement in perfusion is possibly due to changes in nitric oxide signaling. Hypoxia-conditioned extracellular vesicles represent a potential therapeutic strategy to increase myocardial perfusion in patients with advanced coronary artery disease.</p></div>","PeriodicalId":74032,"journal":{"name":"JTCVS open","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S266627362400161X/pdfft?md5=3c49ce287b9addf97d357dc18a02db15&pid=1-s2.0-S266627362400161X-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141413368","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Alternative Discharge Destination Following Lobectomy: An Analysis of a National Quality Improvement Database","authors":"Victoria Yin, S. Wightman, Takashi Harano, S.M. Atay, Anthony W. Kim","doi":"10.1016/j.xjon.2024.06.020","DOIUrl":"https://doi.org/10.1016/j.xjon.2024.06.020","url":null,"abstract":"","PeriodicalId":74032,"journal":{"name":"JTCVS open","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141692218","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Autonomous Fontan pump: computational feasibility study","authors":"M. Rodefeld, Timothy Conover, Richard Figliola, Mike Neary, G. Giridharan, Artem Ivashchenko, Edward M. Bennett","doi":"10.1016/j.xjon.2024.07.003","DOIUrl":"https://doi.org/10.1016/j.xjon.2024.07.003","url":null,"abstract":"","PeriodicalId":74032,"journal":{"name":"JTCVS open","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141693539","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessing the Impact of Socioeconomic Distress on Hospital Readmissions After Cardiac Surgery","authors":"Mohamad El Moheb, Abhinav Kareddy, Steven Young, Matthew Weber, Sean Noona, Alexander Wisniewski, Anthony V. Norman, Zeyad Sahli, Raymond Strobel, Andrew Young, Jeffrey Rich, Abdulla A Damluji, Mohammed Quader, L. Yarboro, Nicholas Teman, O. Preventza","doi":"10.1016/j.xjon.2024.07.002","DOIUrl":"https://doi.org/10.1016/j.xjon.2024.07.002","url":null,"abstract":"","PeriodicalId":74032,"journal":{"name":"JTCVS open","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141693106","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Commentator Discussion: Type B Aortic Dissection in Marfan Patients after the David Procedure: Insights from Patient-Specific Simulation","authors":"Farshad Tajeddinisarvestani, Duke Cameron, Jennifer Chung","doi":"10.1016/j.xjon.2024.06.016","DOIUrl":"https://doi.org/10.1016/j.xjon.2024.06.016","url":null,"abstract":"","PeriodicalId":74032,"journal":{"name":"JTCVS open","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141689444","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Investigation of a Chronic Single-Stage Sheep Fontan Model","authors":"John M. Kelly, Zinan Hu, Felipe Takaesu, Tatsuya Watanabe, Judd Storrs, Benjamin Blais, Satoshi Yuhara, Adrienne Morrison, Kirsten Nelson, Anudari Ulziibayar, Eric Heuer, Cole Anderson, Michael Jimenez, Joseph T Leland, Raphael Malbrue, Carmen Arsuaga-Zorrilla, Laurie Goodchild, Aymen Naguib, Christopher McKee, Jordan Varner, Cameron DeShetler, Joshua Spiess, Andrew Harrison, Brian A Boe, Aimee K. Armstrong, Arash Salavitabar, Kan N. Hor, Rajesh Krishnamurthy, Andrew R. Yates, T. Shinoka, Sergio A. Carrillo, Michael E. Davis, Alison L. Marsden, Christopher K Breuer","doi":"10.1016/j.xjon.2024.06.018","DOIUrl":"https://doi.org/10.1016/j.xjon.2024.06.018","url":null,"abstract":"","PeriodicalId":74032,"journal":{"name":"JTCVS open","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141696904","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Utilizing Machine Learning to Predict Neurological Injury in Venovenous Extracorporeal Membrane Oxygenation Patients: An ELSO Registry Analysis","authors":"Andrew Kalra, Preetham Bachina, Benjamin L. Shou, Jaeho Hwang, Meylakh Barshay, Shreyas Kulkarni, Isaac Sears, Carsten Eickhoff, Christian A. Bermudez, Daniel Brodie, C. Ventetuolo, Glenn J R Whitman, Adeel Abbasi, Sung-Min Cho, B. Kim, David Hager, Steven P Keller, Errol L. Bush, R. S. Stephens, Shivalika Khanduja, Jin Kook Kang, Ifeanyi Chinedozi, Zachary Darby, Hannah Rando, Trish Brown, Jiah Kim, Christopher Wilcox, Albert Leng, Andrew Geeza, A. Akbar, Chengyuan Alex Feng, David Zhao, Marc Sussman, P. Mendez-Tellez, Philip Sun, Karlo Capili, Ramon Riojas, Diane Alejo, Scott Stephen, Harry Flaster","doi":"10.1016/j.xjon.2024.06.013","DOIUrl":"https://doi.org/10.1016/j.xjon.2024.06.013","url":null,"abstract":"","PeriodicalId":74032,"journal":{"name":"JTCVS open","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141697796","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Lung Cancer Screening Amongst Minority Groups: Identifying Gaps in Screening and Opportunities for Intervention","authors":"Fatima G. Wilder, Busra Cangut, R. Jindani, Oyepeju Abioye, Narjust Florez","doi":"10.1016/j.xjon.2024.07.001","DOIUrl":"https://doi.org/10.1016/j.xjon.2024.07.001","url":null,"abstract":"","PeriodicalId":74032,"journal":{"name":"JTCVS open","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141707274","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}