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The role of diagnostic laparoscopy in staging distal esophageal adenocarcinoma 腹腔镜诊断在食管远端腺癌分期中的作用
IF 1.9 Pub Date : 2025-12-01 DOI: 10.1016/j.xjon.2025.09.010
Stella T. Tsui MD , Nanruoyi Zhou MD , Kay See Tan PhD , Junting Zheng MS , Katherine D. Gray MD , Smita Sihag MD , Valerie W. Rusch MD , Manjit S. Bains MD , Bernard J. Park MD , Matthew J. Bott MD , James Huang MD , Prasad S. Adusumilli MD , Laura H. Tang MD, PhD , Daniela Molena MD , David R. Jones MD

Objectives

The study objectives were to determine whether diagnostic laparoscopy improves staging accuracy in selected patients with distal esophageal adenocarcinoma and to identify clinicopathologic features associated with positive diagnostic laparoscopy.

Methods

Patients with distal esophageal adenocarcinoma who underwent diagnostic laparoscopy from 2000 to 2023 at a single institution were identified from a prospectively maintained surgical database. Exclusion criteria included performance of diagnostic laparoscopy after systemic therapy, absence of staging positron computed tomography/computed tomography, and M1 disease before diagnostic laparoscopy. Fisher exact test and Wilcoxon rank-sum test were used to compare categorical and continuous variables, respectively, between patients with negative and positive diagnostic laparoscopy. Clinicopathologic features were assessed using multivariable logistic regression.

Results

In total, 226 of 2131 patients with distal esophageal adenocarcinoma (11%) underwent diagnostic laparoscopy; 93% of these patients (211/226) had clinical T stage 3 or more. Most patients had clinical stage III disease before diagnostic laparoscopy (205/226 [91%]). In total, 183 patients (81%) had negative diagnostic laparoscopy, and 43 patients (19%) had positive diagnostic laparoscopy. In 40 patients (20%), disease was upstaged from III to IVB after positive diagnostic laparoscopy. Distal esophageal adenocarcinoma with signet ring feature (odds ratio, 2.45, 95% CI, 1.05-5.86; P = .040) was associated with positive diagnostic laparoscopy. Cardia involvement (P = .581), clinical T stage (P > .999), presence of clinical nodal disease (P = .550), clinical stage before diagnostic laparoscopy (P > .999), maximum standardized uptake value (P = .124), and poor differentiation without signet ring feature (P = .341) were not associated with positive diagnostic laparoscopy.

Conclusions

Signet ring feature is associated with peritoneal disease. The use of diagnostic laparoscopy in these patients may lead to better staging and more appropriate treatment strategies.
研究目的是确定诊断性腹腔镜检查是否能提高选定的食管远端腺癌患者的分期准确性,并确定与诊断性腹腔镜检查阳性相关的临床病理特征。方法从一个前瞻性维护的外科数据库中确定2000年至2023年在单一机构接受腹腔镜诊断的远端食管腺癌患者。排除标准包括全身性治疗后诊断性腹腔镜检查的表现,没有分期正电子计算机断层扫描/计算机断层扫描,诊断性腹腔镜检查前M1疾病。采用Fisher精确检验和Wilcoxon秩和检验分别比较诊断性腹腔镜检查阴性和阳性患者的分类变量和连续变量。采用多变量logistic回归评估临床病理特征。结果2131例食管远端腺癌患者中226例(11%)行诊断性腹腔镜检查;这些患者中有93%(211/226)的临床T期达到或超过3期。大多数患者在诊断腹腔镜检查前已处于临床III期疾病(205/226[91%])。其中183例(81%)诊断性腹腔镜检查阴性,43例(19%)诊断性腹腔镜检查阳性。在40例(20%)患者中,诊断性腹腔镜检查阳性后,疾病从III级上升到IVB级。伴有印戒征的远端食管腺癌(优势比为2.45,95% CI为1.05-5.86;P = 0.040)与腹腔镜诊断阳性相关。贲门受累(P = .581)、临床T分期(P > .999)、有无临床淋巴结病变(P = .550)、诊断前临床分期(P > .999)、最大标准化摄取值(P = .124)、无印戒征分化差(P = .341)与诊断性腹腔镜检查阳性无相关性。结论印戒征与腹膜疾病有关。在这些患者中使用诊断性腹腔镜检查可能会导致更好的分期和更合适的治疗策略。
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引用次数: 0
The state of educational research in cardiothoracic surgery: A review of the literature 心胸外科教育研究现状:文献综述
IF 1.9 Pub Date : 2025-12-01 DOI: 10.1016/j.xjon.2025.10.010
Amirtha Shekar BS , Victoria Hart BS , John Treffalls MD , Travis J. Miles MD , Todd K. Rosengart MD , Marc R. Moon MD , Joseph S. Coselli MD , Lauren M. Barron MD , Shawn S. Groth MD , Shanda H. Blackmon MD , Ravi K. Ghanta MD , Dawn S. Hui MD , Subhasis Chatterjee MD

Objective

Evolving training paradigms in cardiothoracic surgery (CTS) are changing the educational needs of integrated residents and traditional fellows. Educational research is important for evaluating specialty training. This study assessed CTS education articles to analyze their prevalence, content, and reach.

Methods

In a cross-sectional observational study of education articles published on North American CTS programs from January 2013 through December 2023, articles were identified by querying PubMed, other databases, and journals. Articles that passed an initial abstract review underwent full-text review. Articles were organized by content into 9 categories: curriculum, simulation, trainee assessment, program evaluation, wellness/burnout, diversity/inclusion, mentorship/career, outcomes, and trainee perceptions. Data were analyzed with univariate statistics and the Mann-Kendall test.

Results

A total of 124 CTS education articles from 20 journals were identified, comprising 0.15% of the 84,005 articles published across these journals. The greatest volume of articles came from Annals of Thoracic Surgery (41%) and Journal of Thoracic and Cardiovascular Surgery (26%). PlumX metrics revealed that each article had a median of 11 interaction citations (interquartile range, 6.0-22.0; n = 113) and 23 captures (interquartile range, 11-47; n = 101). Common topics were curriculum (n = 39, 32%) and simulation training (n = 19, 15%). Manuscripts with ≥11 citations had greater PlumX metrics (P < .001). The annual CTS publication volume of educational articles averaged 11.3 ± 4.0; excluding pandemic years, this volume showed no significant increase from 2013-2019 to 2023 (P = .80).

Conclusions

Approximately 10 articles per year are published on CTS education and training. Increased efforts in the CTS community are needed to encourage and disseminate education research.
目的:不断发展的心胸外科(CTS)培训模式正在改变住院医师和传统医师的教育需求。教育研究是评价专业培养的重要手段。本研究评估CTS教育文章,以分析其流行程度、内容和覆盖范围。方法对2013年1月至2023年12月在北美CTS项目上发表的教育文章进行横断面观察研究,通过查询PubMed、其他数据库和期刊来确定文章。通过初步摘要审查的文章进行全文审查。文章按内容分为9类:课程、模拟、学员评估、项目评估、健康/倦怠、多样性/包容性、指导/职业、成果和学员感知。采用单变量统计和Mann-Kendall检验对数据进行分析。结果共鉴定出来自20种期刊的124篇CTS教育论文,占这些期刊发表的84,005篇论文的0.15%。最多的文章来自Annals of Thoracic Surgery(41%)和Journal of Thoracic and Cardiovascular Surgery(26%)。PlumX指标显示,每篇文章的交互引用中位数为11次(四分位数范围为6.0-22.0,n = 113),捕获次数为23次(四分位数范围为11-47,n = 101)。常见的主题是课程(n = 39, 32%)和模拟训练(n = 19, 15%)。引用次数≥11次的论文具有更高的PlumX指标(P < .001)。CTS教育类文章年平均发表量11.3±4.0篇;排除大流行年份,从2013-2019年到2023年,这一数量没有显著增加(P = 0.80)。结论每年大约有10篇关于CTS教育和培训的文章发表。需要加强CTS社区的努力,以鼓励和传播教育研究。
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引用次数: 0
Surgical skills assessment during resident selection process: Survey of American cardiothoracic and Canadian cardiac surgery program directors 住院医师选择过程中的外科技能评估:对美国心胸外科和加拿大心脏外科项目主任的调查
IF 1.9 Pub Date : 2025-12-01 DOI: 10.1016/j.xjon.2025.08.009
Klaudiusz Stoklosa MD , Elie Fadel MDCM(c) , Terrence M. Yau MDCM, MSc

Objective

Matching into cardiothoracic and cardiac surgery training programs is highly competitive. As surgical simulation becomes increasingly accessible, we present the various perspectives of program directors (PDs) on the potential assessment of surgical skills during the resident selection process.

Methods

A 21-question survey was distributed to all 128 accredited American cardiothoracic (75 indirect-entry 5 + 2, 19 indirect-entry 4 + 3, and 34 direct-entry I-6 programs) and 12 Canadian direct-entry cardiac surgery residency programs. Questions were focused on respondent demographic characteristics, sentiments toward integration of surgical skills assessment in resident selection, and perceptions of residents’ technical skills at different stages of training. A similar questionnaire was distributed to all 360 American and Canadian general surgery PDs given its foundation for indirect-entry cardiothoracic surgery fellowships. Data were analyzed descriptively and quantitatively.

Results

Forty-nine American cardiothoracic (38%), 10 Canadian cardiac (83%), 50 American general (15%), and 10 Canadian general (59%) surgery PDs completed the survey. Cardiothoracic and cardiac surgery PDs were divided on whether surgical skill assessment should be part of the selection process (yes: 52.5%; n = 31). Although 35.6% (n = 21) believed residents were slightly underperforming at the start of training, 50.9% (n = 30) believed residents were slightly or significantly overperforming by the end. Similar patterns were seen among general surgery responses.

Conclusions

Surgical skills assessment during the resident selection process is divisive among cardiothoracic and cardiac surgery PDs. Surgical skills remain largely untested before residency but are developed throughout training.
目的心外科培训项目的匹配竞争非常激烈。随着手术模拟越来越容易获得,我们提出了项目主任(pd)在住院医师选择过程中对外科技能的潜在评估的各种观点。方法对128个经认证的美国心胸外科(75个间接进入的5 + 2项目,19个间接进入的4 + 3项目,34个直接进入的I-6项目)和12个加拿大直接进入的心脏外科住院医师项目进行21个问题的调查。问题集中在受访者的人口特征、对住院医生选择中外科技能评估的看法,以及对住院医生在不同培训阶段的技术技能的看法。一份类似的调查问卷被分发给所有360名美国和加拿大的普通外科博士,因为它是间接进入心胸外科奖学金的基础。对数据进行描述性和定量分析。结果美国心胸外科医师49名(38%),加拿大心脏科医师10名(83%),美国普通外科医师50名(15%),加拿大普通外科医师10名(59%)。心胸外科和心脏外科医师在是否应将手术技能评估作为选择过程的一部分方面存在分歧(赞成:52.5%;n = 31)。35.6% (n = 21)的人认为住院医生在培训开始时表现略差,50.9% (n = 30)的人认为住院医生在培训结束时表现略好或明显好。在普通外科反应中也发现了类似的模式。结论在住院医师选择过程中,外科技能评估在心胸外科和心外科副医师之间存在分歧。外科技能在住院医师之前基本上没有经过测试,但在整个培训过程中得到了发展。
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引用次数: 0
Considerations for the equitable selection of thoracic surgery residents and fellows 胸外科住院医师和研究员公平选择的考虑
IF 1.9 Pub Date : 2025-12-01 DOI: 10.1016/j.xjon.2025.09.042
Ahmet Kilic MD , Mara B. Antonoff MD , Kathleen S. Berfield MD , David T. Cooke MD , Thomas K. Varghese MD, MS, MBA , Mark Orringer MD

Background

Equitable selection of surgical trainees is essential to maintaining the integrity and excellence that is central to cardiothoracic surgical education. Selection processes must ensure that all candidates are evaluated fairly and consistently, minimizing bias while identifying those with the greatest potential for technical competence, clinical excellence, and upholding the principles of professionalism. Despite progress, many current approaches remain overly reliant on academic metrics that do not fully capture the attributes required for success in surgical training and practice.

Objective

This expert opinion article examines contemporary challenges and evolving priorities in achieving a fair and equitable selection of surgical trainees, drawing on experience in surgical education, program leadership, and performance assessment.

Results

Traditional selection metrics—such as academic achievement, standardized test scores, and research productivity—remain valuable but insufficient predictors of operative aptitude, resilience, teamwork, and ethical judgment. Emerging evidence supports a more comprehensive evaluation framework that incorporates behavioral and situational assessments, structured interviews, and evaluation of professional attributes such as integrity, adaptability, and commitment to improvement. This article proposes a multidimensional selection model designed to improve predictive validity and fairness in trainee recruitment and assessment.

Conclusions

The future of surgical education depends on refining selection processes to identify candidates with both technical potential and the personal characteristics essential for excellence in cardiothoracic surgery. An evidence-informed, transparent, and equitable approach to trainee selection will strengthen the specialty and ensure the continued delivery of high-quality patient care.
背景:公平选择外科培训生对于保持心胸外科教育的完整性和卓越性至关重要。遴选过程必须确保对所有候选人进行公平和一致的评估,尽量减少偏见,同时确定那些在技术能力和临床表现方面最有潜力的候选人,并坚持专业原则。尽管取得了进展,但目前的许多方法仍然过度依赖于学术指标,而这些指标并不能完全捕获外科培训和实践中成功所需的属性。目的:这篇专家意见文章探讨了在外科教育、项目领导和绩效评估方面的经验,探讨了实现公平公正选择外科培训生的当代挑战和不断变化的优先事项。结果传统的选拔指标——如学术成就、标准化考试成绩和研究效率——仍然有价值,但不足以预测操作能力、弹性、团队合作和道德判断。新出现的证据支持一个更全面的评估框架,该框架包括行为和情境评估、结构化访谈以及对诚信、适应性和改进承诺等专业属性的评估。本文提出了一个多维选择模型,旨在提高学员招聘和评估的预测有效性和公平性。结论外科教育的未来取决于改进选拔过程,以确定具有技术潜力和个人特征的候选人,这些候选人是优秀心胸外科手术所必需的。循证、透明和公平的培训生选择方法将加强专业,并确保持续提供高质量的患者护理。
{"title":"Considerations for the equitable selection of thoracic surgery residents and fellows","authors":"Ahmet Kilic MD ,&nbsp;Mara B. Antonoff MD ,&nbsp;Kathleen S. Berfield MD ,&nbsp;David T. Cooke MD ,&nbsp;Thomas K. Varghese MD, MS, MBA ,&nbsp;Mark Orringer MD","doi":"10.1016/j.xjon.2025.09.042","DOIUrl":"10.1016/j.xjon.2025.09.042","url":null,"abstract":"<div><h3>Background</h3><div>Equitable selection of surgical trainees is essential to maintaining the integrity and excellence that is central to cardiothoracic surgical education. Selection processes must ensure that all candidates are evaluated fairly and consistently, minimizing bias while identifying those with the greatest potential for technical competence, clinical excellence, and upholding the principles of professionalism. Despite progress, many current approaches remain overly reliant on academic metrics that do not fully capture the attributes required for success in surgical training and practice.</div></div><div><h3>Objective</h3><div>This expert opinion article examines contemporary challenges and evolving priorities in achieving a fair and equitable selection of surgical trainees, drawing on experience in surgical education, program leadership, and performance assessment.</div></div><div><h3>Results</h3><div>Traditional selection metrics—such as academic achievement, standardized test scores, and research productivity—remain valuable but insufficient predictors of operative aptitude, resilience, teamwork, and ethical judgment. Emerging evidence supports a more comprehensive evaluation framework that incorporates behavioral and situational assessments, structured interviews, and evaluation of professional attributes such as integrity, adaptability, and commitment to improvement. This article proposes a multidimensional selection model designed to improve predictive validity and fairness in trainee recruitment and assessment.</div></div><div><h3>Conclusions</h3><div>The future of surgical education depends on refining selection processes to identify candidates with both technical potential and the personal characteristics essential for excellence in cardiothoracic surgery. An evidence-informed, transparent, and equitable approach to trainee selection will strengthen the specialty and ensure the continued delivery of high-quality patient care.</div></div>","PeriodicalId":74032,"journal":{"name":"JTCVS open","volume":"28 ","pages":"Pages 753-759"},"PeriodicalIF":1.9,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145697968","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Outcomes after postcardiotomy venoarterial extracorporeal membrane oxygenation in young patients: An individual patient data meta-analysis 年轻患者心脏切开术后静脉动脉体外膜氧合的结果:个体患者数据荟萃分析
IF 1.9 Pub Date : 2025-12-01 DOI: 10.1016/j.xjon.2025.09.046
Ilaria Giambuzzi MD , Fausto Biancari MD, PhD , Giorgio Mastroiacovo MD , Alexander Kaserer MD , Camilla L'Acqua MD , Vito G. Ruggieri MD, PhD , Sung-Min Cho MD, PhD , Magnus Dalén MD, PhD , Henryk Welp MD , Kristján Jónsson MD , Sigurdur Ragnarsson MD, PhD , Francisco J. Hernández Pérez MD , Giuseppe Gatti MD , Khalid Alkhamees MD , Antonio Loforte MD, PhD , Andrea Lechiancole MD , Paola D'Errigo MSc , Stefano Rosato MSc , Cristiano Spadaccio MD , Matteo Pettinari MD , Giorgia Bonalumi MD

Objective

We aimed to evaluate the early and midterm mortality of young patients treated for cardiogenic shock with venoarterial extracorporeal membrane oxygenation (VA-ECMO) after adult cardiac surgery.

Methods

Studies reporting the outcome after postcardiotomy VA-ECMO in adult patients were identified through a systematic review of the literature. Individual patient-level data were provided by the authors of 10 studies.

Results

Data on 1268 patients treated at 25 hospitals were included in this study. Adjusted analysis identified 40 years of age as a cutoff value for in-hospital and mid-term mortality. Patients aged >40 years had significantly greater in-hospital mortality (1129 patients, crude rates 68.8% vs 43.1%, adjusted odds ratio, 3.267; 95% confidence interval, 1.970-5.425) and mortality at 24-month (109 patients, crude rates 73.7% vs 45.0%, adjusted hazard ratio, 3.530, 95% confidence interval, 2.571-4.844). Twelve (11.0%) patients aged ≤40 years received a ventricular assist device and heart transplantation, whereas this strategy was adopted in 33 (2.9%) patients aged >40 years (P < .001). Eventually, 7 (6.4%) patients aged ≤40 years and 12 (1.1%) patients aged >40 years underwent heart transplantation (P < .001). Heart transplantation tended to decrease in-hospital mortality in patients aged ≤40 years (14.3% vs 45.1%, P = .138), whereas this difference reached statistical significance in patients aged >40 years (25.0% vs 69.3%, P = .002).

Conclusions

The present findings suggest that early and midterm mortality after postcardiotomy VA-ECMO is significantly lower in patients aged ≤40 years compared to older patients. However, mortality remains substantial also among these young patients and heart-replacement therapies are infrequently performed in this subset of patients likely because of severe perioperative complications.
目的探讨成人心脏手术后静脉动脉体外膜氧合(VA-ECMO)治疗心源性休克的早期和中期死亡率。方法通过对文献的系统回顾,对报道成人患者心脏切开术后VA-ECMO结果的研究进行鉴定。个别患者水平的数据由10项研究的作者提供。结果本研究纳入25家医院1268例患者的数据。调整分析确定40岁为住院死亡率和中期死亡率的临界值。40岁患者的住院死亡率(1129例,粗比值为68.8%比43.1%,校正后的95%可信区间为1.970-5.425)和24个月死亡率(109例,粗比值为73.7%比45.0%,校正后的95%可信区间为3.530,95%可信区间为2.571-4.844)显著高于40岁患者。12名(11.0%)年龄≤40岁的患者接受了心室辅助装置和心脏移植,而33名(2.9%)年龄≤40岁的患者采用了这一策略(P < 0.001)。最终,年龄≤40岁的7例(6.4%)、年龄≤40岁的12例(1.1%)行心脏移植手术(P < 0.001)。心脏移植有降低≤40岁患者住院死亡率的趋势(14.3% vs 45.1%, P = .138),而≤40岁患者住院死亡率差异有统计学意义(25.0% vs 69.3%, P = .002)。结论:年龄≤40岁的患者与老年患者相比,心切术后VA-ECMO的早期和中期死亡率明显降低。然而,这些年轻患者的死亡率仍然很高,由于严重的围手术期并发症,这类患者很少进行心脏替代治疗。
{"title":"Outcomes after postcardiotomy venoarterial extracorporeal membrane oxygenation in young patients: An individual patient data meta-analysis","authors":"Ilaria Giambuzzi MD ,&nbsp;Fausto Biancari MD, PhD ,&nbsp;Giorgio Mastroiacovo MD ,&nbsp;Alexander Kaserer MD ,&nbsp;Camilla L'Acqua MD ,&nbsp;Vito G. Ruggieri MD, PhD ,&nbsp;Sung-Min Cho MD, PhD ,&nbsp;Magnus Dalén MD, PhD ,&nbsp;Henryk Welp MD ,&nbsp;Kristján Jónsson MD ,&nbsp;Sigurdur Ragnarsson MD, PhD ,&nbsp;Francisco J. Hernández Pérez MD ,&nbsp;Giuseppe Gatti MD ,&nbsp;Khalid Alkhamees MD ,&nbsp;Antonio Loforte MD, PhD ,&nbsp;Andrea Lechiancole MD ,&nbsp;Paola D'Errigo MSc ,&nbsp;Stefano Rosato MSc ,&nbsp;Cristiano Spadaccio MD ,&nbsp;Matteo Pettinari MD ,&nbsp;Giorgia Bonalumi MD","doi":"10.1016/j.xjon.2025.09.046","DOIUrl":"10.1016/j.xjon.2025.09.046","url":null,"abstract":"<div><h3>Objective</h3><div>We aimed to evaluate the early and midterm mortality of young patients treated for cardiogenic shock with venoarterial extracorporeal membrane oxygenation (VA-ECMO) after adult cardiac surgery.</div></div><div><h3>Methods</h3><div>Studies reporting the outcome after postcardiotomy VA-ECMO in adult patients were identified through a systematic review of the literature. Individual patient-level data were provided by the authors of 10 studies.</div></div><div><h3>Results</h3><div>Data on 1268 patients treated at 25 hospitals were included in this study. Adjusted analysis identified 40 years of age as a cutoff value for in-hospital and mid-term mortality. Patients aged &gt;40 years had significantly greater in-hospital mortality (1129 patients, crude rates 68.8% vs 43.1%, adjusted odds ratio, 3.267; 95% confidence interval, 1.970-5.425) and mortality at 24-month (109 patients, crude rates 73.7% vs 45.0%, adjusted hazard ratio, 3.530, 95% confidence interval, 2.571-4.844). Twelve (11.0%) patients aged ≤40 years received a ventricular assist device and heart transplantation, whereas this strategy was adopted in 33 (2.9%) patients aged &gt;40 years (<em>P</em> &lt; .001). Eventually, 7 (6.4%) patients aged ≤40 years and 12 (1.1%) patients aged &gt;40 years underwent heart transplantation (<em>P</em> &lt; .001). Heart transplantation tended to decrease in-hospital mortality in patients aged ≤40 years (14.3% vs 45.1%, <em>P</em> = .138), whereas this difference reached statistical significance in patients aged &gt;40 years (25.0% vs 69.3%, <em>P</em> = .002).</div></div><div><h3>Conclusions</h3><div>The present findings suggest that early and midterm mortality after postcardiotomy VA-ECMO is significantly lower in patients aged ≤40 years compared to older patients. However, mortality remains substantial also among these young patients and heart-replacement therapies are infrequently performed in this subset of patients likely because of severe perioperative complications.</div></div>","PeriodicalId":74032,"journal":{"name":"JTCVS open","volume":"28 ","pages":"Pages 278-295"},"PeriodicalIF":1.9,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145698152","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Multiple applications of the Florida sleeve procedure in aortic root surgery 佛罗里达套筒手术在主动脉根部手术中的多种应用
IF 1.9 Pub Date : 2025-12-01 DOI: 10.1016/j.xjon.2025.09.035
Liu Chenyu MD, Li Haochao MD, Chen Pengfei MD, Wang Liqing MD, Luo Xinjin MD
{"title":"Multiple applications of the Florida sleeve procedure in aortic root surgery","authors":"Liu Chenyu MD,&nbsp;Li Haochao MD,&nbsp;Chen Pengfei MD,&nbsp;Wang Liqing MD,&nbsp;Luo Xinjin MD","doi":"10.1016/j.xjon.2025.09.035","DOIUrl":"10.1016/j.xjon.2025.09.035","url":null,"abstract":"","PeriodicalId":74032,"journal":{"name":"JTCVS open","volume":"28 ","pages":"Pages 109-116"},"PeriodicalIF":1.9,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145698072","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Design, benefits, and use of a hybrid aortic arch stent graft 混合型主动脉弓支架的设计、益处和使用
IF 1.9 Pub Date : 2025-12-01 DOI: 10.1016/j.xjon.2025.08.011
Ryaan EL-Andari MD, Michael C. Moon MD
{"title":"Design, benefits, and use of a hybrid aortic arch stent graft","authors":"Ryaan EL-Andari MD,&nbsp;Michael C. Moon MD","doi":"10.1016/j.xjon.2025.08.011","DOIUrl":"10.1016/j.xjon.2025.08.011","url":null,"abstract":"","PeriodicalId":74032,"journal":{"name":"JTCVS open","volume":"28 ","pages":"Pages 121-125"},"PeriodicalIF":1.9,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145698074","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Endoscopic hydrodissection for vein harvesting in coronary artery bypass grafting: The minimally invasive no-touch (MINT) technique 冠状动脉旁路移植术中静脉的内窥镜解剖:微创无接触(MINT)技术
IF 1.9 Pub Date : 2025-12-01 DOI: 10.1016/j.xjon.2025.08.017
John F. Gallagher MD , Victor Garcia PhD , Steven Escaravage MHS, PA-C , Pamela Gallagher MD , Paul J. Gallagher MSc , Danielle Diegisser PhD , William Davalan , Walid Ben Ali MD, PhD , Maximilian Y. Emmert MD, PhD , Daniel Fusco MD , Louis P. Perrault MD, PhD
{"title":"Endoscopic hydrodissection for vein harvesting in coronary artery bypass grafting: The minimally invasive no-touch (MINT) technique","authors":"John F. Gallagher MD ,&nbsp;Victor Garcia PhD ,&nbsp;Steven Escaravage MHS, PA-C ,&nbsp;Pamela Gallagher MD ,&nbsp;Paul J. Gallagher MSc ,&nbsp;Danielle Diegisser PhD ,&nbsp;William Davalan ,&nbsp;Walid Ben Ali MD, PhD ,&nbsp;Maximilian Y. Emmert MD, PhD ,&nbsp;Daniel Fusco MD ,&nbsp;Louis P. Perrault MD, PhD","doi":"10.1016/j.xjon.2025.08.017","DOIUrl":"10.1016/j.xjon.2025.08.017","url":null,"abstract":"","PeriodicalId":74032,"journal":{"name":"JTCVS open","volume":"28 ","pages":"Pages 238-241"},"PeriodicalIF":1.9,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145698149","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Reply: Issues regarding graft selection and surgical strategy 回答:关于移植物选择和手术策略的问题
IF 1.9 Pub Date : 2025-12-01 DOI: 10.1016/j.xjon.2025.09.037
Yuki Kuroda MD , Hiroki Shiomi MD , Kenji Minatoya MD
{"title":"Reply: Issues regarding graft selection and surgical strategy","authors":"Yuki Kuroda MD ,&nbsp;Hiroki Shiomi MD ,&nbsp;Kenji Minatoya MD","doi":"10.1016/j.xjon.2025.09.037","DOIUrl":"10.1016/j.xjon.2025.09.037","url":null,"abstract":"","PeriodicalId":74032,"journal":{"name":"JTCVS open","volume":"28 ","pages":"Page 277"},"PeriodicalIF":1.9,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145698151","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Resectable non−small cell lung cancer in women: A disease-specific entity? 可切除的女性非小细胞肺癌:疾病特异性实体?
IF 1.9 Pub Date : 2025-12-01 DOI: 10.1016/j.xjon.2025.09.002
Marisa Sewell MD , Thomas Boerner MD , Nicolas Toumbacaris MSPH , Kay See Tan PhD , Giye Choe MD , Caitlin Harrington MD , Smita Sihag MD , Prasad S. Adusumilli MD , Matthew J. Bott MD , Robert J. Downey MD , James Huang MD , James M. Isbell MD , Bernard J. Park MD , Gaetano Rocco MD , Katherine Gray MD , Valerie W. Rusch MD , David R. Jones MD , Daniela Molena MD

Objective

There may be important sex-specific differences among patients with non−small cell lung cancer (NSCLC). Despite this, women are underrepresented in prospective clinical trials. We evaluated sex-specific differences in clinicopathologic and genetic factors and survival among patients with NSCLC.

Methods

This is a single-center study at a high-volume dedicated cancer hospital. Patients with NSCLC who underwent complete surgical resection from 2010 to 2018 were included. Primary outcomes include cumulative incidence of recurrence and overall survival, stratified by sex.

Results

Overall, 3452 patients were included; 2033 (59%) were women. More women than men were never-smokers (24% vs 13%; P < .001). Among patients who smoked, women had a significantly shorter pack-year history (30 vs 40 years; P < .001). Comorbid pulmonary (29% vs 35%; P < .001) and cardiac (53% vs 66%; P < .001) conditions were less common among women. Women had lower rates of clinical stage II or III disease (P < .001) and were more likely to have EGFR (28% vs 18%; P < .001) or KRAS (36% vs 29%; P = .018) mutations. Median overall survival among women was 11 years (95% confidence interval [CI], 10 years to not reached), compared with 7.9 years among men (95% CI, 7.5-8.6). This longer survival was sustained on multivariable analysis (hazard ratio, 0.86; 95% CI, 0.76-0.97; P = .013). Cumulative incidence of recurrence was not statistically different by sex (hazard ratio, 0.95; 95% CI, 0.82-1.09; P = .43).

Conclusions

Clinicopathologic and genetic factors and survival among patients with NSCLC differ on the basis of sex. NSCLC in women should be considered a disease-specific entity.
目的非小细胞肺癌(NSCLC)患者之间可能存在重要的性别特异性差异。尽管如此,女性在前瞻性临床试验中的代表性不足。我们评估了非小细胞肺癌患者在临床病理和遗传因素以及生存方面的性别差异。方法本研究为单中心研究,在一家高容量的肿瘤专科医院进行。纳入了2010年至2018年接受完全手术切除的非小细胞肺癌患者。主要结局包括按性别分层的累积复发率和总生存率。结果共纳入3452例患者;2033名(59%)是女性。从不吸烟的女性多于男性(24%比13%;P < .001)。在吸烟的患者中,女性有明显较短的包年病史(30年vs 40年;P < 0.001)。肺部合并症(29% vs 35%; P < 0.001)和心脏合并症(53% vs 66%; P < 0.001)在女性中较少见。女性临床II期或III期疾病发生率较低(P < 0.001),更有可能发生EGFR(28%对18%;P < 0.001)或KRAS(36%对29%;P = 0.018)突变。女性患者的中位总生存期为11年(95%可信区间[CI], 10年至未达到),而男性患者的中位总生存期为7.9年(95% CI, 7.5-8.6)。在多变量分析中,这种较长的生存期得以维持(风险比,0.86;95% CI, 0.76-0.97; P = 0.013)。累积复发率在性别上无统计学差异(风险比0.95;95% CI 0.82-1.09; P = 0.43)。结论非小细胞肺癌患者的临床病理、遗传因素及生存率存在性别差异。女性非小细胞肺癌应被视为一种疾病特异性实体。
{"title":"Resectable non−small cell lung cancer in women: A disease-specific entity?","authors":"Marisa Sewell MD ,&nbsp;Thomas Boerner MD ,&nbsp;Nicolas Toumbacaris MSPH ,&nbsp;Kay See Tan PhD ,&nbsp;Giye Choe MD ,&nbsp;Caitlin Harrington MD ,&nbsp;Smita Sihag MD ,&nbsp;Prasad S. Adusumilli MD ,&nbsp;Matthew J. Bott MD ,&nbsp;Robert J. Downey MD ,&nbsp;James Huang MD ,&nbsp;James M. Isbell MD ,&nbsp;Bernard J. Park MD ,&nbsp;Gaetano Rocco MD ,&nbsp;Katherine Gray MD ,&nbsp;Valerie W. Rusch MD ,&nbsp;David R. Jones MD ,&nbsp;Daniela Molena MD","doi":"10.1016/j.xjon.2025.09.002","DOIUrl":"10.1016/j.xjon.2025.09.002","url":null,"abstract":"<div><h3>Objective</h3><div>There may be important sex-specific differences among patients with non−small cell lung cancer (NSCLC). Despite this, women are underrepresented in prospective clinical trials. We evaluated sex-specific differences in clinicopathologic and genetic factors and survival among patients with NSCLC.</div></div><div><h3>Methods</h3><div>This is a single-center study at a high-volume dedicated cancer hospital. Patients with NSCLC who underwent complete surgical resection from 2010 to 2018 were included. Primary outcomes include cumulative incidence of recurrence and overall survival, stratified by sex.</div></div><div><h3>Results</h3><div>Overall, 3452 patients were included; 2033 (59%) were women. More women than men were never-smokers (24% vs 13%; <em>P</em> &lt; .001). Among patients who smoked, women had a significantly shorter pack-year history (30 vs 40 years; <em>P</em> &lt; .001). Comorbid pulmonary (29% vs 35%; <em>P</em> &lt; .001) and cardiac (53% vs 66%; <em>P</em> &lt; .001) conditions were less common among women. Women had lower rates of clinical stage II or III disease (<em>P</em> &lt; .001) and were more likely to have <em>EGFR</em> (28% vs 18%; <em>P</em> &lt; .001) or <em>KRAS</em> (36% vs 29%; <em>P</em> = .018) mutations. Median overall survival among women was 11 years (95% confidence interval [CI], 10 years to not reached), compared with 7.9 years among men (95% CI, 7.5-8.6). This longer survival was sustained on multivariable analysis (hazard ratio, 0.86; 95% CI, 0.76-0.97; <em>P</em> = .013). Cumulative incidence of recurrence was not statistically different by sex (hazard ratio, 0.95; 95% CI, 0.82-1.09; <em>P</em> = .43).</div></div><div><h3>Conclusions</h3><div>Clinicopathologic and genetic factors and survival among patients with NSCLC differ on the basis of sex. NSCLC in women should be considered a disease-specific entity.</div></div>","PeriodicalId":74032,"journal":{"name":"JTCVS open","volume":"28 ","pages":"Pages 526-540"},"PeriodicalIF":1.9,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145697716","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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