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Antidiabetic, and radical scavenging activity of Kigelia africana fruit fractions. Kigelia africana 果实馏分的抗糖尿病和自由基清除活性。
Pub Date : 2023-12-02 DOI: 10.55320/mjz.50.1.376
Tumelo Muyenga, Dominion Samuel K Bamitale, Dan Kibuule, C. Hikaambo, Mutenta N Nyambe, Christian Ezeala
Background: Traditional medicine is gaining traction in Africa. 92.1% of diabetes patients at the University Teaching Hospital in Zambia use herbal medicine. Kigelia africana is a botanical species used in traditional medicine for diabetes due to its phytochemical composition. This study aimed to determine the phytoconstituents, radical scavenging activities, total flavonoid concentration, and total phenolic content of the antidiabetic bioactive Kigelia africana fruit fractions. Methods: Using UV spectrophotometer we determined the total phenolic content (TPC), total flavonoid content (TFC) and free radical scavenging activity. Alloxan-induced diabetes rat models were used to determine the antidiabetic effect in vivo. Phytoconstituent analysis was via gas-chromatography Mass spectrophotometry (GC-MS) Results: The ethyl acetate fraction demonstrated superior antidiabetic activity, reducing blood glucose levels from 28.42±2.7 mmol/l to 8.16±4.4 mmol/l. Statistical analysis showed no significant difference between the ethyl acetate fraction and Glibenclamide,(p=0.152). Although the ethyl acetate fraction had a higher reading, there was no statistically significant difference found in Total Phenolic content (TPC) (p=0.3) and Total Flavonoid content (TFC) (p=0.06). IC50 values for DPPH were 0.05330 (chloroform), 0.05352 (ethyl acetate), and 0.4013 (butanol). GC-MS analysis revealed the presence of important fatty acids, methyl furfural, furan carboxylic acid and 4-pyran-4-one derivatives. Conclusion: The GC-MS fingerprint of the antidiabetic fractions revealed important fatty acids and phenolic compounds that could be attributed to the observed antidiabetic activity.
背景:传统医学在非洲越来越受欢迎,赞比亚大学教学医院92.1%的糖尿病患者使用草药。由于其植物化学成分,非洲桂枝是传统医学中用于治疗糖尿病的植物物种。本研究旨在测定具有抗糖尿病生物活性的非洲桂树果实各组分的植物成分、自由基清除活性、总黄酮浓度和总酚含量。方法:采用紫外分光光度法测定其总酚含量(TPC)、总黄酮含量(TFC)和自由基清除能力。采用四氧嘧啶诱导的糖尿病大鼠模型,在体内观察其抗糖尿病作用。结果:乙酸乙酯部位具有良好的降糖活性,使血糖水平从28.42±2.7 mmol/l降至8.16±4.4 mmol/l。经统计学分析,乙酸乙酯部位与格列本脲无显著差异(p=0.152)。虽然乙酸乙酯部分的读数较高,但总酚含量(TPC) (p=0.3)和总黄酮含量(TFC) (p=0.06)差异无统计学意义。DPPH的IC50值分别为0.05330(氯仿)、0.05352(乙酸乙酯)和0.4013(丁醇)。气相色谱-质谱分析发现了重要的脂肪酸、甲基糠醛、呋喃羧酸和4-吡喃-4-酮衍生物。结论:抗糖尿病组分的GC-MS指纹图谱显示了可能与抗糖尿病活性有关的重要脂肪酸和酚类化合物。
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引用次数: 0
Evaluation of Fine Needle Aspiration for diagnosis of Tuberculous Lymphadenitis in Children using the Xpert MTB/RIF Ultra at the University Teaching Hospitals Children’s Hospital, Lusaka, Zambia 在赞比亚卢萨卡大学教学医院儿童医院使用 Xpert MTB/RIF Ultra 评估细针抽吸法诊断儿童结核性淋巴结炎的效果
Pub Date : 2023-11-15 DOI: 10.55320/mjz.49.4.387
Andrew Chisanga, Evans Mpabalwani, Aaron Nyirenda, D. Banda, C. Chabala
Background: Tuberculous Lymphadenitis (TBL) is the commonest form of Extra Pulmonary TB and poses diagnostic challenges in setting with no access to Histopathology. Our goal was to evaluate the diagnostic yield of Xpert MTB Ultra performed on lymph node aspirate obtained using Fine Needle Aspiration (FNA) in children with suspected TBL. Methods: This was a cross-sectional study conducted at a tertiary and main referral hospital in Zambia. Children aged 6 months to 15 years with lymphadenopathy and presumed TBL were enrolled. FNA was performed and lymph node aspirate samples were analysed using XPERT MTB/RIF ULTRA. Data was collected and analysed as frequencies and percentages. Logistic regression was used to measure the odds of testing positive for MTB. Results: Sixty one children were enrolled in the study, 34(55.7%) were males and a median age of 6 years (IQR: 3-11 years). Sixteen (26%) were diagnosed with TB, 7 on clinical basis while, one was positive on gastric lavage, five (31%) were positive for TB on lymph node FNA using Xpert MTB/RIF Ultra. Then, 3 were positive Histopathology, with one also positive on XPERT MTB/RIF Ultra. Alternative diagnosis included malignancies like lymphomas and acute Leukemias. While non malignant lymphadenopathy included, benign reactive lymphadenopathy and HIV associated lymphadenopathy. The prevalence of HIV among the children diagnosed with TB was 37.5% (6/16). Thirty one percent (5/16) of children with TB had a close contact with TB, OR=9.0 (95% CI: 1.3-77, p-value (<0.05). Conclusion: TBL is not uncommon in children presenting with Lymphadenopathy. FNA is a less invasive, inexpensive technique and coupled with use of Xpert MTB/RIF Ultra has potential for early diagnosis of TBL, in a low resource setting with limited Histopathology services.
背景:结核性淋巴结炎(TBL)是肺外结核病中最常见的一种,在无法进行组织病理学检查的情况下给诊断带来了挑战。我们的目标是评估 Xpert MTB Ultra 对疑似 TBL 儿童淋巴结抽吸物的诊断率。方法:这是一项横断面研究:这是一项横断面研究,在赞比亚的一家三级主要转诊医院进行。研究对象为患有淋巴结病并推测为 TBL 的 6 个月至 15 岁儿童。采用XPERT MTB/RIF ULTRA对淋巴结穿刺抽吸样本进行分析。收集的数据以频率和百分比进行分析。采用逻辑回归法测定 MTB 检测呈阳性的几率。结果:61名儿童参加了研究,其中34名(55.7%)为男性,中位年龄为6岁(IQR:3-11岁)。16名儿童(26%)被诊断出患有肺结核,其中7名儿童的临床诊断结果为肺结核,1名儿童的洗胃结果呈阳性,5名儿童(31%)的淋巴结FNA检测结果呈阳性(Xpert MTB/RIF Ultra)。此外,3 人的组织病理学结果呈阳性,其中一人的 Xpert MTB/RIF Ultra 检测结果也呈阳性。替代诊断包括淋巴瘤和急性白血病等恶性肿瘤。非恶性淋巴结病包括良性反应性淋巴结病和艾滋病相关淋巴结病。在确诊为肺结核的儿童中,HIV 感染率为 37.5%(6/16)。31%的肺结核患儿(5/16)与肺结核患者有密切接触,OR=9.0(95% CI:1.3-77,P 值(<0.05))。 结论TBL在淋巴腺病儿童中并不少见。FNA 是一种创伤小、成本低的技术,在组织病理学服务有限、资源匮乏的环境中,与 Xpert MTB/RIF Ultra 结合使用,可用于 TBL 的早期诊断。
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引用次数: 0
Prevalence, Awareness And Adverse Outcomes Of Breast Ironing Among Cameroonian Women In Buea Health District 布埃亚卫生区喀麦隆妇女对熨烫乳房的流行率、认识和不良后果
Pub Date : 2023-11-15 DOI: 10.55320/mjz.49.4.391
Mela Fotabong, Gbolahan Obajimi, Temitayo Lawal, Imran Morhason-Bello
Background: Breast ironing, also known as breast flattening, is a practice that involves the use of an object to massage, press, or pound the breast. This practice is usually performed on girls, between the ages of 9 and 15 years The known effects of breast ironing are self-reported symptoms or signs of breast ironing by the victims. This study aims to investigate the prevalence, awareness, and adverse outcomes of Cameroonian women towards breast ironing. Methods: A mixed method design involving qualitative and cross-sectional study among women aged 18years and above. The primary outcome variable was previous experience of breast ironing. Log-binomial model was used to determine effects of breast-ironing on selected reproductive health outcomes. Results: Of 160 women interviewed, 22 (14%) had experienced breast ironing. The mean age was 26±4.62 years. All participants were aware of breast ironing. There were significant associations between being a victim of breast ironing and parity, breast symmetry, nipple anatomy, breast pain, milk quantity during lactation, breast sagging. The risk of reporting breast ironing was higher among women who experienced breast sagging earlier than expected, women who reported breast pain and women whose breasts had marked asymmetry. Conclusion: Breast ironing is prevalent in the Buea health district of Cameroon, and victims are more likely to experience adverse breast outcomes. Health education and introduction of legislation against breast ironing will go a long way to eliminate this harmful traditional practice. More studies will help to further understand drivers of breast ironing in other regions of Cameroon.
背景:熨烫乳房又称平胸,是一种使用物体按摩、按压或捶打乳房的做法。乳房熨烫的已知影响是受害者自我报告的乳房熨烫症状或体征。本研究旨在调查喀麦隆妇女对熨胸的发生率、认识和不良后果。 研究方法采用混合方法设计,对 18 岁及以上女性进行定性和横断面研究。主要结果变量是以前熨烫乳房的经历。采用对数二项式模型确定熨胸对某些生殖健康结果的影响。结果:在 160 名受访女性中,22 人(14%)有过熨烫乳房的经历。平均年龄为 26±4.62 岁。所有参与者都知道乳房熨烫。乳房熨烫与奇偶性、乳房对称性、乳头解剖学、乳房疼痛、哺乳期乳量和乳房下垂之间存在明显关联。报告乳房下垂早于预期的妇女、报告乳房疼痛的妇女和乳房明显不对称的妇女报告乳房熨烫的风险更高。结论在喀麦隆的布埃亚卫生区,熨烫乳房的现象很普遍,而且受害者更有可能经历不良的乳房后果。健康教育和立法禁止熨胸将大大有助于消除这种有害的传统做法。更多的研究将有助于进一步了解喀麦隆其他地区熨烫乳房的驱动因素。
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引用次数: 0
Mad Dogs and Englishmen - A case of fatal hyperthermia in military personnel 疯狗和英国人--军人致命的高热症病例
Pub Date : 2023-11-15 DOI: 10.55320/mjz.49.4.394
Dr K Saasa, K. Saasa¹, Mss Patel²
A case of fatal hyperthermia in a military personnel is reported. It highlights the health hazards of over exposure to hot temperatures. A clinico-pathological aspect of the topic is discussed.
报告了一例军人致命的高热症病例。该病例强调了过度暴露于高温环境对健康的危害。本文还讨论了该主题的临床病理学方面。
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引用次数: 0
Gestational Diabetes Mellitus among women attending antenatal clinic in a Tertiary Hospital in Northern Nigeria 尼日利亚北部一家三级医院产前检查妇女中的妊娠糖尿病
Pub Date : 2023-11-15 DOI: 10.55320/mjz.49.4.389
A. Danladi, Y. Aremu-Kasumu, Kabiru B. Sada, Olaniyi T. Fasanu, Sikiru A. Yusuf
Introduction: Women with gestational diabetes mellitus (GDM) are at an increased risk of adverse perinatal and maternal morbidities and mortalities. Hence, early detection and management of this condition is vital to ensure a good outcome for both mother and baby. Aim: The aim of the study is to determine the prevalence and associated risk factors for GDM among antenatal attendees in Federal Medical Centre Gusau (FMCG), Zamfara state, Nigeria. Methods: A descriptive cross-sectional study was carried out. Screening was done between 24 and 28-weeks gestational age with a 75g oral glucose tolerance test (OGTT). Plasma glucose measurements was performed using the glucose oxidase method. GDM was diagnosed according to the 2013 WHO diagnostic criteria. Data were collected using a proforma and analyzed using the Statistical Package for Social Sciences (SPSS) Version 26. Descriptive data were presented in frequency tables. Statistical testing using Chi-square, and multivariate analysis (Odd ratio and CI) were carried out with a level of significance set as P< 0.05. Results: One hundred and thirty-six women between the gestational ages of 24-28 weeks were recruited. The mean age of the participants was 25.9±5.4 years. The prevalence of GDM was found to be 16.9%. Fasting blood glucose alone correctly diagnosed 87% of the patients. Previous history of macrosomic babies (≥4kg) and history of GDM in previous pregnancies were significantly associated with GDM. Conclusion: The prevalence of GDM is high among antenatal attendees in Federal Medical center, Gusau.
导言:患有妊娠糖尿病(GDM)的妇女围产期和孕产期的不良发病率和死亡率都会增加。因此,及早发现和治疗这种疾病对确保母婴的良好结局至关重要。 目的:本研究旨在确定尼日利亚赞法拉州古绍联邦医疗中心(FMCG)产前就诊者中 GDM 的患病率和相关风险因素。研究方法进行了一项描述性横断面研究。筛查在孕龄 24 至 28 周之间进行,采用 75 克口服葡萄糖耐量试验 (OGTT)。使用葡萄糖氧化酶法进行血浆葡萄糖测量。GDM 根据 2013 年世界卫生组织诊断标准进行诊断。数据使用表格收集,并使用社会科学统计软件包(SPSS)第 26 版进行分析。描述性数据以频率表的形式呈现。使用卡方和多变量分析(奇数比和 CI)进行统计检验,显著性水平设定为 P< 0.05。结果共招募了 136 名孕龄在 24-28 周之间的妇女。参与者的平均年龄为(25.9±5.4)岁。发现 GDM 患病率为 16.9%。仅凭空腹血糖就能正确诊断出 87% 的患者。既往巨型儿(≥4 千克)史和既往妊娠 GDM 史与 GDM 有显著相关性。结论GDM 在古绍联邦医疗中心的产前就诊者中发病率很高。
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引用次数: 0
A Comparative Review of the Efficacy of 24-HourVersus 48-Hour Dose Regimen of Amoxicillin/Clavulanic Acid Prophylaxis forpostoperative infections following elective Caesarean Section at the University College Hospital, Ibadan, Nigeria: A Randomized Clinical Trial 尼日利亚伊巴丹大学学院医院对择期剖腹产术后感染采用阿莫西林/克拉维酸 24 小时剂量方案与 48 小时剂量方案的疗效对比研究:随机临床试验
Pub Date : 2023-11-15 DOI: 10.55320/mjz.49.4.388
Olakunle Olawole Oloko, O. Ogunbode, Gbolahan Obajimi, Ayodele Arowojolu
Objectives: To compare the efficacy of 24hour versus 48hour prophylaxis of amoxicillin/clavulanic acid in the prevention of postoperative infections. Study Design: This study was a randomized controlled clinical trial conducted in a tertiary hospital in Ibadan, Nigeria. Two hundred and fifty -two pregnant women scheduled for elective caesarean section were randomly assigned into two groups. After the initial pre-incision antibiotic administration, group A received the Amoxicillin/Clavulanic Acid for 24 hours while group B received the same drug for 48hours. Main Outcomes: Participants were examined on the 3rd, 10th and 17th post-operative days for evidence of infections. All entry and analysis of data was by computer using the Statistical Package for Social Sciences version 22 (IBM, New York). Statistically significant differences were determined at p value of < 0.05. Results: The incidence of postoperative wound infection, postoperative fever and endometritis in this study was 5.2%, 9.1% and 5.6% respectively. There was no significant differences in the incidence of postoperative wound infection, postoperative fever and endometritis between the two regimens of antibiotics. Conclusion: A 24-hour prophylactic regimen of amoxicillin/clavulanic acid is adequate following caesarean section and prolonged use of antibiotics is generally unnecessary, costly and inadvertently increases antibiotics resistance
目的比较阿莫西林/克拉维酸 24 小时预防性用药和 48 小时预防性用药在预防术后感染方面的疗效。研究设计:本研究是一项随机对照临床试验,在尼日利亚伊巴丹的一家三级医院进行。计划进行选择性剖腹产的 252 名孕妇被随机分配到两组。在最初的切口前抗生素给药后,A 组接受阿莫西林/克拉维酸治疗 24 小时,B 组接受相同药物治疗 48 小时。主要结果:在术后第 3 天、第 10 天和第 17 天检查受试者有无感染迹象。所有数据的输入和分析均通过计算机进行,使用的是社会科学统计软件包第 22 版(IBM,纽约)。以 P 值小于 0.05 为差异有统计学意义。结果本研究中术后伤口感染、术后发烧和子宫内膜炎的发生率分别为 5.2%、9.1% 和 5.6%。两种抗生素方案的术后伤口感染、术后发热和子宫内膜炎发生率无明显差异。结论剖腹产术后使用阿莫西林/克拉维酸 24 小时预防方案就足够了,长期使用抗生素通常是不必要的、昂贵的,而且会无意中增加抗生素的耐药性。
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引用次数: 0
Changing Roles of a Radiographer in Fluoroscopy: 放射技师在透视检查中的角色转变:
Pub Date : 2023-11-15 DOI: 10.55320/mjz.49.4.393
O. Bwanga, Ernest Chanda, Edward Mwansa, Billy Nkoloma
Fluoroscopic imaging services in Zambia have been available since 1972 when the first equipment was installed at the University Teaching Hospital (UTH). However, there is limited fluoroscopy equipment use due to a critical shortage of radiologists who are traditionally trained to carry out this role. Radiologists work alongside radiographers who provide technical support and patient care. To address the shortage of radiologists, radiographers in the United Kingdom (UK) have explicitly expanded their scope of practice and started performing and reporting on fluoroscopic examinations such as barium swallow, barium meal, small bowel follow-through, barium enema, and videofluoroscopy after undergoing appropriate training. Literature from the UK shows that gastrointestinal (GI) radiographers’ performance is of a high-quality standard. The initiative has been very effective and made a significant contribution to the delivery of fluoroscopic services in that country. Therefore, the aim of this article was to review the literature on role extension for GI radiographers to guide the development and practice of fluoroscopic studies in Zambia. It is anticipated that this article will bring awareness to stakeholders such as the Ministry of Health (MOH), Schools of Radiography, the Radiological Society of Zambia (RSZ), and the Zambia Medical Association (ZMA) on this important subject.
赞比亚自 1972 年在大学教学医院(UTH)安装了第一台透视成像设备后,便开始提供透视成像服务。然而,由于传统上接受过相关培训的放射科医生严重短缺,透视设备的使用非常有限。放射科医生与放射技师一起工作,后者提供技术支持和病人护理。为了解决放射科医生短缺的问题,英国的放射技师明确扩大了他们的执业范围,并在接受适当培训后开始执行和报告荧光透视检查,如吞钡、钡餐、小肠随访、钡灌肠和视频荧光透视检查。来自英国的文献显示,胃肠道(GI)放射技师的表现达到了高质量标准。这一举措非常有效,为该国提供透视服务做出了重大贡献。因此,本文旨在回顾有关消化道放射技师角色扩展的文献,以指导赞比亚透视研究的发展和实践。预计本文将提高卫生部(MOH)、放射摄影学校、赞比亚放射学会(RSZ)和赞比亚医学协会(ZMA)等利益相关方对这一重要课题的认识。
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引用次数: 0
Patient’s Satisfaction with Use of Spinal Anaesthesia for Day-Case gynaecological procedures 患者对在日间妇科手术中使用脊髓麻醉的满意度
Pub Date : 2023-11-15 DOI: 10.55320/mjz.49.4.392
Nweze Onochie Uchenna, Ebirim Longinus Ndubuisi, Alagbe-Briggs OlubusolaTemitope
Background: Patient Satisfaction is defined as the individual’s positive evaluation of a distinct dimension of care. Satisfaction is positive when the perception of the care given meets pateints’ level of expectation. The ideal anaesthesia for ambulatory procedures should provide a rapid and smooth onset of action, good intraoperative analgesia, good operating condition, short recovery time free from side effect and high level of patient satisfaction. Patient satisfaction is a vital part of assessing quality of care, and different instruments have been developed to measure it without a consensus on an ideal one. Achieving high satisfaction among patients that undergo day case gynaecological procedures under spinal would promote the acceptance of this anaesthetic technique in our locality. Method: This was an observational prospective study in which ninety (90) patients aged 18 – 45 years with ASA class I or II scheduled for day case gynaecological procedures were recruited. Spinal anaesthesia was given in sitting position using a range of 7.5mg to 10mg of 0.5% hyperbaric bupivacaine. The procedures lasted less than one (1) hour, during which the haemodynamic parameters (SBP, DBP MAP Pulse rate, and Spo2) were monitored continually. Patients were discharged home on the same day of procedure. Two days following the procedure, a structured questionnaire on patient’s satisfaction level was administered via phone call and data collected included satisfaction with explanation of the anaesthesia for the procedure, postoperative complications and overall level of satisfaction, and acceptance of spinal anaesthesia in the future. Results: Outcome showed that 88 patients (97.8%) were overall satisfied with the use of spinal anaesthesia for Day case gynaecological procedures and 2 patients (2.2%) were not satisfied with the anaesthetic technique used for the procedure. All the patients accepted to use spinal anaesthesia for similar procedure in the future.
背景:病人满意度的定义是个人对护理的某一不同方面的积极评价。当患者对所提供的护理服务的感知达到其期望水平时,其满意度就是正面的。理想的非卧床手术麻醉应该是起效迅速、平稳,术中镇痛效果好,手术条件好,恢复时间短,无副作用,病人满意度高。患者满意度是评估医疗质量的重要组成部分,目前已开发出不同的测量工具,但尚未就理想的测量工具达成共识。如果在脊柱麻醉下进行日间妇科手术的患者满意度较高,将促进该麻醉技术在本地的接受度。研究方法这是一项前瞻性观察研究,共招募了 90 名年龄在 18-45 岁之间、ASA 分级为 I 级或 II 级、计划接受日间妇科手术的患者。患者采取坐位,使用7.5毫克至10毫克的0.5%高压布比卡因进行脊柱麻醉。手术持续时间不到一(1)小时,在此期间持续监测血流动力学参数(SBP、DBP、MAP 脉搏率和 Spo2)。患者在手术当天出院回家。术后两天,通过电话对患者的满意度进行了结构化问卷调查,收集的数据包括对手术麻醉解释的满意度、术后并发症和总体满意度,以及今后对脊髓麻醉的接受程度。结果显示结果显示,88 名患者(97.8%)对在日间妇科手术中使用脊髓麻醉总体满意,2 名患者(2.2%)对手术中使用的麻醉技术不满意。所有患者都同意今后在类似手术中使用脊髓麻醉。
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引用次数: 0
Aspiration of Barium Contrast by a Geriatric Patient with Gastroparesis 老年胃轻瘫患者吸钡造影剂1例
Pub Date : 2023-08-14 DOI: 10.55320/mjz.49.3.358
Shamiso Sharon Chitemamwise, B. Chinene
Complications due to aspiration of barium contrast occur rarely during studies of the digestive tract. While lung tissue can tolerate small amounts of Barium large quantities can exceed the lung’s capacity and consequently lead to death especially, in geriatric patients. Barium contrast can affect pulmonary ventilation and perfusion function, causing dyspnoea, hypoxemia and respiratory failure. We herein report a barium swallow case in which an 82-year-old woman aspirated barium on the first swallow and was diagnosed with Gastroparesis. The history, procedure and patient management are discussed. The purpose of the case report is to add to the existing literature on aspiration cases during barium swallow studies and the outcomes after the aspiration. Furthermore, this case report also highlights a need for extra care when attending to senior patients with dysphagia during barium studies.
在消化道研究中,由于吸入钡造影剂引起的并发症很少发生。虽然肺组织可以耐受少量的钡,但大量的钡可超过肺的容量,从而导致死亡,特别是在老年患者中。钡造影剂可影响肺通气和灌注功能,引起呼吸困难、低氧血症和呼吸衰竭。我们在此报告一例吞咽钡的病例,其中一名82岁的妇女在第一次吞咽时吸入钡,并被诊断为胃轻瘫。讨论了手术的历史、程序和病人的管理。本病例报告的目的是补充现有文献中关于钡剂吞咽研究中误吸病例和误吸后的结果。此外,本病例报告还强调了在钡餐检查期间照顾吞咽困难的老年患者时需要额外的照顾。
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引用次数: 0
In vivo Anti-anaemic Effect of an Aqueous Root Extract of Phyllanthus muellerianus (Kuntze) Exell in Model Rats 千叶草根水提物对模型大鼠的体内抗贫血作用
Pub Date : 2023-08-14 DOI: 10.55320/mjz.49.3.357
J. Nyirenda, Gershom B. Lwanga, K. Muzandu, D. Chuba, G. Sijumbila
Background: Anaemia is a very serious condition in Zambia. One of the plants that has been used traditionally is Phyllanthus muellerianus where different parts of shrub are used to treat a number of diseases in Zambian folklore medicine. Earlier studies have investigated medicinal properties of its aqueous root extracts. This study evaluated the effect of P. muellerianus roots on the haematological indices of albino rats and determined its phytochemical profile. In order to prove this, we carried out phytochemical screening of the root extract and assessed the anti-anaemic effect of the aqueous extract on laboratory rats with tail-bled induced anaemia.Materials and Methods: Thirty-six male albino rats placed in six groups were used for the study. The groups comprised the 100, 200, and 400 mg/kg plant extract, Ranferon (200 mg/kg positive control), anaemic (non-treated control) and a normal (non-anaemic control) groups. Anaemia, induced through bleeding of the rats, was defined as haemoglobin (Hb) levels less than 12 g/dL. The anti-anaemic potential of the plant was determined by comparing its effect on the haematological parameters of rats on treatment to that of the control group.Results: Phytochemical screening revealed positive results for alkaloids, flavonoids, saponins, glycosides, steroids, triterpenoids and tannins with varying amounts. After treatment, rats on the 400 mg/kg plant extract dose showed the greatest increase in the mean values for Hb, Packed cell volume (PCV) and RBC count were 43.31.2%, 15.40.3 g/dL and 6.30.3 x106 /L respectively, when compared to the negative control group (P < 0.05).Conclusions: The aqueous root extract of P. muellerianus was efficacious against anaemia in a dose-dependent manner. The phytochemical compositions seem to be responsible for its haematopoietic properties. Thus, the root decoction of P. muellerianus is useful in alleviating anaemia and the results lend credence to its use in traditional medicine in the management of anaemia.
背景:贫血在赞比亚是一种非常严重的疾病。传统上使用的植物之一是Phyllanthus muellerianus,在赞比亚民间医学中,灌木的不同部分被用来治疗许多疾病。早期的研究已经调查了其水根提取物的药用特性。本研究评价了木勒根对白化大鼠血液学指标的影响,并测定了其植物化学特征。为了证明这一点,我们对根提取物进行了植物化学筛选,并评估了水提取物对尾出血性贫血实验大鼠的抗贫血作用。材料与方法:选用雄性白化大鼠36只,分为6组。各组分为100、200和400 mg/kg植物提取物组、Ranferon组(200 mg/kg阳性对照)、贫血组(未处理对照组)和正常组(非贫血对照组)。大鼠出血引起的贫血定义为血红蛋白(Hb)水平低于12 g/dL。通过与对照组比较其对大鼠血液学参数的影响来确定该植物的抗贫血潜力。结果:植物化学筛选结果显示,生物碱、黄酮类化合物、皂苷、糖苷、类固醇、三萜和单宁均有不同数量的阳性结果。处理后,与阴性对照组相比,400 mg/kg剂量组大鼠血红蛋白、堆积细胞体积(PCV)和红细胞计数的平均值分别增加43.31.2%、15.40.3 g/dL和6.30.3 x106 /L,增幅最大(P < 0.05)。结论:木耳根水提物对贫血有一定的治疗作用,且呈剂量依赖性。植物化学成分似乎是其造血特性的原因。因此,穆勒草的根煎液在缓解贫血方面是有用的,研究结果为其在传统医学中治疗贫血提供了依据。
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引用次数: 0
期刊
Medical journal of Zambia
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