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Medicina clinica (English ed.)最新文献

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Common variable immunodeficiency 常见可变免疫缺陷
Medicina clinica (English ed.)
Pub Date : 2025-11-01 DOI: 10.1016/j.medcle.2025.107168
Xavier Solanich , Arnau Antolí , Laia Alsina
Common variable immunodeficiency (CVID) is characterised by defective differentiation of B lymphocytes, hypogammaglobulinemia, and infections, although its clinical presentation is much more heterogeneous, with autoimmunity, interstitial lung disease, enteropathy, lymphoproliferation, malignancy, among others. Patients with CVID should undergo extensive immunological evaluations and regular assessment of the multiple organs that may be affected, ideally by multidisciplinary teams specialised in immunodeficiencies. Infections usually improve significantly after the initiation of immunoglobulin replacement therapy and other preventive measures, with non-infectious manifestations now posing the greatest therapeutic challenge. Identifying a genetic cause allows for the reclassification of patients, it has prognostic and therapeutic implications, and enables genetic counselling for family members.
常见变异性免疫缺陷（CVID）的特征是B淋巴细胞分化缺陷、低γ -球蛋白血症和感染，尽管其临床表现更为异质性，包括自身免疫、间质性肺疾病、肠病、淋巴细胞增殖、恶性肿瘤等。CVID患者应接受广泛的免疫学评估，并定期对可能受影响的多个器官进行评估，最好由专门研究免疫缺陷的多学科团队进行评估。感染通常在免疫球蛋白替代治疗和其他预防措施开始后显著改善，非感染性表现目前构成最大的治疗挑战。确定遗传原因可以对患者进行重新分类，具有预后和治疗意义，并可以为家庭成员提供遗传咨询。
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引用次数: 0
Impact of vericiguat on functional class and hospitalizations in patients with heart failure and reduced ejection fraction: A retrospective cohort study vericiguat对心力衰竭和射血分数降低患者功能分级和住院的影响：一项回顾性队列研究
Medicina clinica (English ed.)
Pub Date : 2025-11-01 DOI: 10.1016/j.medcle.2025.107067
José María Medina-Gil , Acerina Rodríguez-Reyes , Efrén Martínez-Quintana
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引用次数: 0
Benign familial pemphigus 良性家族性天疱疮
Medicina clinica (English ed.)
Pub Date : 2025-11-01 DOI: 10.1016/j.medcle.2025.107063
Álvaro Mínguez Contreras, Enrique García Soler, Cristina Albanell Fernández
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引用次数: 0
Multiple strokes as a presentation of neurosyphilis in a patient with HIV infection HIV感染患者的神经梅毒表现为多次中风
Medicina clinica (English ed.)
Pub Date : 2025-11-01 DOI: 10.1016/j.medcle.2025.107177
Vanesa Garrigasait Vilaseca , Mª del Mar Gutierrez Macia , Sara Castells Buchle
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引用次数: 0
Delayed coral contact dermatitis 迟发性珊瑚接触性皮炎
Medicina clinica (English ed.)
Pub Date : 2025-11-01 DOI: 10.1016/j.medcle.2025.107176
Sara Becerril-Andrés , Margarita Llavador-Ros , Miguel Mansilla-Polo
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引用次数: 0
Frailty and time to mortality from infection in the emergency department 在急诊科，虚弱和时间与感染的死亡率
Medicina clinica (English ed.)
Pub Date : 2025-11-01 DOI: 10.1016/j.medcle.2025.107188
Javier Jacob, Elena Fuentes, Ferran Llopis
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引用次数: 0
Stevens-Johnson syndrome/toxic epidermal necrolysis-like acute cutaneous lupus erythematosus 史蒂文斯-约翰逊综合征/中毒性表皮坏死松解样急性皮肤红斑狼疮
Medicina clinica (English ed.)
Pub Date : 2025-11-01 DOI: 10.1016/j.medcle.2025.107198
María Concepción Campos Mármol , Leonardo Bascón Rodríguez , José Manuel Mascaró-Galy
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引用次数: 0
Prevalence of symptoms and quality of life 3 years after COVID-19: Long term follow-up using the C19-YRS questionnaire in a Spanish hospital COVID-19后3年的症状患病率和生活质量：在西班牙一家医院使用C19-YRS问卷进行长期随访
Medicina clinica (English ed.)
Pub Date : 2025-11-01 DOI: 10.1016/j.medcle.2025.107138
Blanca Ayuso García , Antía Pérez López , Yoana Besteiro Balado , Eva Romay Lema , Álvaro Marchán-López , Ramón Rabuñal Rey

Background

Post-COVID syndrome can hinder the quality of life of patients. This study aims at describing this syndrome and its natural history.

Methods

Prospective study including 443 inpatient and outpatient survivors of COVID-19 acquired between March and May 2020. Patients with dementia, nursing home residents, and those rejecting participation were excluded. Symptoms were assessed 10 and 36 months after the infection using the C19-YRS questionnaire. The prevalence and severity of symptoms, as well as risk factors for symptom persistence were investigated.

Results

At 10 months 62.3% of patients reported at least one symptom, down to 54.9% at 36 months. Fatigue (37.2%), dyspnea at exertion (33.4%), and anxiety (33.4%) were the most prevalent symptoms, all of which showed improvement at follow up. Domain-specific impairment was the strongest risk factor for symptom persistence. Most patients reported a similar health status (69.4%) and quality of life (71.4%) compared with their pre-infection condition.

Conclusions

Although frequent, post-COVID-19 symptoms improve over time, while quality of life remains stable compared to patients baseline status.
新冠肺炎后综合征会影响患者的生活质量。本研究旨在描述该综合征及其自然病史。方法前瞻性研究纳入443例2020年3月至5月期间获得的COVID-19住院和门诊幸存者。痴呆患者、养老院居民和拒绝参与的人被排除在外。在感染后10个月和36个月使用C19-YRS问卷评估症状。调查了症状的患病率和严重程度，以及症状持续的危险因素。结果10个月时62.3%的患者报告至少一种症状，36个月时下降到54.9%。疲劳（37.2%）、用力时呼吸困难（33.4%）和焦虑（33.4%）是最常见的症状，这些症状在随访时均有所改善。领域特异性损伤是症状持续的最大危险因素。与感染前相比，大多数患者报告的健康状况（69.4%）和生活质量（71.4%）相似。结论虽然频繁，但随着时间的推移，covid -19后症状会改善，而与患者基线状态相比，生活质量保持稳定。
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引用次数: 0
Tinea genitalis
Medicina clinica (English ed.)
Pub Date : 2025-10-01 DOI: 10.1016/j.medcle.2025.107064
Elisabeth Gómez Moyano , Fátima Moreno Suárez , Leandro Martínez Pilar
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引用次数: 0
Skin infection by Mycobacterium marinum. Study of 8 patients 海洋分枝杆菌皮肤感染。8例患者的研究
Medicina clinica (English ed.)
Pub Date : 2025-10-01 DOI: 10.1016/j.medcle.2025.107110
Joaquim Marcoval, Júlia Boronat-Cucarull, Marta Gangonells-Dols
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引用次数: 0
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