George Fotakopoulos, Ioannis Siasios, C. Gatos, V. Georgakopoulou, N. Trakas, P. Sklapani, K. Fountas
{"title":"Acute intracranial hemorrhage during the installation of the LICOX microdialysis system: A case report","authors":"George Fotakopoulos, Ioannis Siasios, C. Gatos, V. Georgakopoulou, N. Trakas, P. Sklapani, K. Fountas","doi":"10.3892/mi.2024.163","DOIUrl":"https://doi.org/10.3892/mi.2024.163","url":null,"abstract":"","PeriodicalId":74161,"journal":{"name":"Medicine international","volume":"48 29","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140965723","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Omar Obeidat, Ali Obeidat, Abedallah Obeidat, Mohamed Ismail
. Doxorubicin (DOX), a cornerstone of cancer chemotherapy, is marred by its dose‑dependent cardiotoxicity, leading to cardiomyopathy and heart failure. The epidemi‑ ology of DOX‑related cardiotoxicity highlights its cumulative, progressive nature, with a significant impact on the health of patients. The pathophysiological mechanisms involve mitochondrial dysfunction, oxidative stress and disrupted calcium homeostasis in cardiomyocytes. Despite the search for effective cardioprotective strategies, current treatments offer limited efficacy. Visnagin emerges as a potential solution, known for its vasodilatory and anti‑inflammatory properties, and recent studies suggest its cardioprotective efficacy against DOX‑induced cardiotoxicity through mitochondrial protection, the modulation of key signaling pathways and the inhibition of apoptosis. The present review aimed to provide a comprehen‑ sive overview of the mechanisms of action of visnagin, as well as to provide experimental evidence, and potential integration into cancer treatment regimens, highlighting its promise as a novel therapeutic agent for managing cardiotoxicity in patients undergoing anthracycline chemotherapy.
{"title":"Visnagin: A novel cardioprotective agent against anthracycline toxicity (Review)","authors":"Omar Obeidat, Ali Obeidat, Abedallah Obeidat, Mohamed Ismail","doi":"10.3892/mi.2024.161","DOIUrl":"https://doi.org/10.3892/mi.2024.161","url":null,"abstract":". Doxorubicin (DOX), a cornerstone of cancer chemotherapy, is marred by its dose‑dependent cardiotoxicity, leading to cardiomyopathy and heart failure. The epidemi‑ ology of DOX‑related cardiotoxicity highlights its cumulative, progressive nature, with a significant impact on the health of patients. The pathophysiological mechanisms involve mitochondrial dysfunction, oxidative stress and disrupted calcium homeostasis in cardiomyocytes. Despite the search for effective cardioprotective strategies, current treatments offer limited efficacy. Visnagin emerges as a potential solution, known for its vasodilatory and anti‑inflammatory properties, and recent studies suggest its cardioprotective efficacy against DOX‑induced cardiotoxicity through mitochondrial protection, the modulation of key signaling pathways and the inhibition of apoptosis. The present review aimed to provide a comprehen‑ sive overview of the mechanisms of action of visnagin, as well as to provide experimental evidence, and potential integration into cancer treatment regimens, highlighting its promise as a novel therapeutic agent for managing cardiotoxicity in patients undergoing anthracycline chemotherapy.","PeriodicalId":74161,"journal":{"name":"Medicine international","volume":"120 32","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140985371","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
George Fotakopoulos, C. Gatos, K. Paterakis, V. Georgakopoulou, Theodosis Spiliotopoulos, Grigorios Christodoulidis, P. Sklapani, N. Trakas, Adamantios Kalogeras, Kostas N. Fountas
Brain abscess (BA) constitutes 1-8% of intra-cerebral tumors, and thus the present study aimed to compare the surgical outcomes of patients with primary and secondary BA. The present retrospective study examined 32 of cases BA who underwent surgery in a local institution between February, 2013 and December, 2023. All patients received intravenous antibiotic therapy according to the antibiogram for antimicrobial susceptibility. In total, 32 patients were separated into two groups as follows: Group A (16 patients, 50%) with primary abscess and group B (16 patients, 50%) with secondary abscess. Of the 32 patients included in the study, 23 (71.8%) were males, and the median age was 55.3 years. On the whole, the present study demonstrates that a multidisciplinary approach involving a combination of often multiple surgical procedures and prolonged antibiotic medication may improve the functional outcome if the underlying pathology allows for a functional outcome.
{"title":"Comparison of surgical outcomes between primary and secondary brain abscess","authors":"George Fotakopoulos, C. Gatos, K. Paterakis, V. Georgakopoulou, Theodosis Spiliotopoulos, Grigorios Christodoulidis, P. Sklapani, N. Trakas, Adamantios Kalogeras, Kostas N. Fountas","doi":"10.3892/mi.2024.160","DOIUrl":"https://doi.org/10.3892/mi.2024.160","url":null,"abstract":"Brain abscess (BA) constitutes 1-8% of intra-cerebral tumors, and thus the present study aimed to compare the surgical outcomes of patients with primary and secondary BA. The present retrospective study examined 32 of cases BA who underwent surgery in a local institution between February, 2013 and December, 2023. All patients received intravenous antibiotic therapy according to the antibiogram for antimicrobial susceptibility. In total, 32 patients were separated into two groups as follows: Group A (16 patients, 50%) with primary abscess and group B (16 patients, 50%) with secondary abscess. Of the 32 patients included in the study, 23 (71.8%) were males, and the median age was 55.3 years. On the whole, the present study demonstrates that a multidisciplinary approach involving a combination of often multiple surgical procedures and prolonged antibiotic medication may improve the functional outcome if the underlying pathology allows for a functional outcome.","PeriodicalId":74161,"journal":{"name":"Medicine international","volume":" 8","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140994979","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Caipeng Xie, Na Li, Yan Chen, Yongtao Liang, Libing Huang, Xiaoyang Xie, Dongming Wang, Haitao Wang, Guanjun Huang
{"title":"Skin and soft tissue infection suspiciously caused by Klebsiella pneumoniae in an aquaculture worker: A case report","authors":"Caipeng Xie, Na Li, Yan Chen, Yongtao Liang, Libing Huang, Xiaoyang Xie, Dongming Wang, Haitao Wang, Guanjun Huang","doi":"10.3892/mi.2024.158","DOIUrl":"https://doi.org/10.3892/mi.2024.158","url":null,"abstract":"","PeriodicalId":74161,"journal":{"name":"Medicine international","volume":"29 9","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140671502","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Association between grip strength and electrical properties measured by bioimpedance spectroscopy in women with dementia aged 77 to 97 years living in group homes","authors":"Kenichiro Yasutake, Hideaki Kumahara, Keisuke Shiose, Marina Kawano, Ryoma Michishita","doi":"10.3892/mi.2024.157","DOIUrl":"https://doi.org/10.3892/mi.2024.157","url":null,"abstract":"","PeriodicalId":74161,"journal":{"name":"Medicine international","volume":" 46","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140684009","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
C. Gatos, George Fotakopoulos, V. Georgakopoulou, Theodosis Spiliotopoulos, P. Sklapani, N. Trakas, Adamantios Kalogeras, Kostas N. Fountas
{"title":"Bone graft absorption complication following cranioplasty: A retrospective institutional study","authors":"C. Gatos, George Fotakopoulos, V. Georgakopoulou, Theodosis Spiliotopoulos, P. Sklapani, N. Trakas, Adamantios Kalogeras, Kostas N. Fountas","doi":"10.3892/mi.2024.156","DOIUrl":"https://doi.org/10.3892/mi.2024.156","url":null,"abstract":"","PeriodicalId":74161,"journal":{"name":"Medicine international","volume":"17 13","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140697391","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
V. Georgakopoulou, Ioannis Lempesis, P. Sklapani, N. Trakas, Demetrios Spandidos
{"title":"Precision medicine for respiratory diseases: A current viewpoint","authors":"V. Georgakopoulou, Ioannis Lempesis, P. Sklapani, N. Trakas, Demetrios Spandidos","doi":"10.3892/mi.2024.155","DOIUrl":"https://doi.org/10.3892/mi.2024.155","url":null,"abstract":"","PeriodicalId":74161,"journal":{"name":"Medicine international","volume":"8 9","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140712097","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
A. Câmpeanu, Mihaela Rus, Sorina Ispas, Alexandra Herlo, Aurora Craciun, Constantin Ionescu, G. Banariu, C. Cambrea, Maria Nicolae, Andreea Nelson-Twakor, Irina-Magdalena Dumitru
Systemic disorders may exhibit early signs when conducting an oral examination. Since the onset of the COVID-19 pandemic, several studies have been published detailing the direct impact of the virus on the oral cavity. The present study aimed to determine whether indeed there are any significant disparities in oropharyngeal manifestations between individuals infected with severe acute respiratory syndrome coronavirus 2 and a control group, and whether the virus has the ability to invade and reproduce inside oral keratinocytes and fibroblasts, resulting in the development of oral ulcerations and superficial lesions. The present study provides an overview of the symptoms that occur at an early stage of the illness, and the most commonly affected regions of the oral cavity, including the tongue, lips, palate and oropharynx are examined. In the present retrospective study, 52 patients infected with COVID-19 were recruited between April, 2021 and October, 2022. In addition, 52 individuals who tested negative for the virus were recruited as the control group. The study was conducted through a thorough examination and questionnaire provided to all participants. The results revealed that among the cohort of patients from the COVID-19 group examined (n=52), a proportion (mean, 16.15) displayed oral manifestations. Specifically, 75% of the patients in the COVID-19 group described oral cavity pain, and 69% of these patients had changes in teeth color or dental caries. In summary, in relation to the control group, the prevalence of oropharyngeal symptoms was generally lower compared to the COVID-19 group, apart from oral cavity pain (30.8%), tonsillitis (17.3%), bleeding (34.6%), teeth color changes (36.5%), recurrence (15.4%) and abscesses (7.7%). Thus, on the whole, the patients without COVID-19 had fewer oral manifestations.
{"title":"Prevalence and association of oral manifestations with disease severity in patients diagnosed with COVID‑19: A cross‑sectional study","authors":"A. Câmpeanu, Mihaela Rus, Sorina Ispas, Alexandra Herlo, Aurora Craciun, Constantin Ionescu, G. Banariu, C. Cambrea, Maria Nicolae, Andreea Nelson-Twakor, Irina-Magdalena Dumitru","doi":"10.3892/mi.2024.154","DOIUrl":"https://doi.org/10.3892/mi.2024.154","url":null,"abstract":"Systemic disorders may exhibit early signs when conducting an oral examination. Since the onset of the COVID-19 pandemic, several studies have been published detailing the direct impact of the virus on the oral cavity. The present study aimed to determine whether indeed there are any significant disparities in oropharyngeal manifestations between individuals infected with severe acute respiratory syndrome coronavirus 2 and a control group, and whether the virus has the ability to invade and reproduce inside oral keratinocytes and fibroblasts, resulting in the development of oral ulcerations and superficial lesions. The present study provides an overview of the symptoms that occur at an early stage of the illness, and the most commonly affected regions of the oral cavity, including the tongue, lips, palate and oropharynx are examined. In the present retrospective study, 52 patients infected with COVID-19 were recruited between April, 2021 and October, 2022. In addition, 52 individuals who tested negative for the virus were recruited as the control group. The study was conducted through a thorough examination and questionnaire provided to all participants. The results revealed that among the cohort of patients from the COVID-19 group examined (n=52), a proportion (mean, 16.15) displayed oral manifestations. Specifically, 75% of the patients in the COVID-19 group described oral cavity pain, and 69% of these patients had changes in teeth color or dental caries. In summary, in relation to the control group, the prevalence of oropharyngeal symptoms was generally lower compared to the COVID-19 group, apart from oral cavity pain (30.8%), tonsillitis (17.3%), bleeding (34.6%), teeth color changes (36.5%), recurrence (15.4%) and abscesses (7.7%). Thus, on the whole, the patients without COVID-19 had fewer oral manifestations.","PeriodicalId":74161,"journal":{"name":"Medicine international","volume":"2013 7","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140718675","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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