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Impact of Smartphone-Enabled Home Urinary Albumin-to-Creatinine Ratio Testing on Albuminuria Screening and Management 智能手机支持的家庭尿白蛋白与肌酐比值检测对蛋白尿筛查和管理的影响
IF 13.2 1区 医学 Q1 UROLOGY & NEPHROLOGY Pub Date : 2025-12-06 DOI: 10.1053/j.ajkd.2025.09.019
Waleed Zafar MD, Yirui Hu PhD, Lauren Brubaker MPH, Nathaniel Harshaw BS, Jamie Green MD MS, Alexander R. Chang MD MS
Early detection of albuminuria can enable administration of therapeutic interventions that improve clinical outcomes in patients at elevated risk for chronic kidney disease (CKD). We investigated the impact of smartphone-enabled home urinary albumin-to-creatinine ratio (UACR) testing on albuminuria screening and clinical management of these patients.
早期发现蛋白尿可以使治疗干预的管理,改善慢性肾脏疾病(CKD)高危患者的临床结果。我们研究了智能手机支持的家庭尿白蛋白与肌酐比值(UACR)测试对这些患者的蛋白尿筛查和临床管理的影响。
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引用次数: 0
Family Physicians' Perspectives on Providing Living Kidney Donor Care. 家庭医生提供活体肾供者护理的观点。
IF 13.2 1区 医学 Q1 UROLOGY & NEPHROLOGY Pub Date : 2025-12-05 DOI: 10.1053/j.ajkd.2025.09.018
Chloe Wong-Mersereau,Saly El Wazze,Kathleen Gaudio,Katya Loban,Shaifali Sandal
RATIONALE & OBJECTIVELiving kidney donors (LKDs) perceive gaps in care along their donation journeys, such as poor coordination and communication between providers. Better integration of their primary care providers (PCPs) in their donation journey can help address these gaps. We sought to capture the perspectives of Canadian PCPs to understand the challenges they perceive when caring for LKDs and their recommendations to address them.STUDY DESIGNQualitative descriptive design.SETTING & PARTICIPANTSSemi-structured in-depth interviews with 19 family physicians conducted until data saturation.ANALYTICAL APPROACHThematic analysis.RESULTSParticipants highlighted several challenges with the current living kidney donation processes: 1) Limited scope of LKD care in primary practice; 2) Poor clarity surrounding roles and responsibilities pre-donation (perceived as a facilitator) and post-donation (perceived as low-barrier and high-access resource, and providing soft psychosocial support); 3) Variable understanding of the living kidney donation process; and 4) Lack of support and resources (patient accessibility to primary care, communication challenges between providers, poor health record transmission, limited availability of mental health services, limited financial support for patients and providers). Participants had three key recommendations: 1) Support PCPs with pragmatic approaches and on-demand resources; 2) Empower LKDs to be active participants in their care; and 3) Implement strategies to address LKD care provision deficiencies (primary care accessibility, developing a collaborative care model, improving communication between all stakeholders, dedicated and prolonged psychosocial support, and governmental prioritization).LIMITATIONSAbout half the sample had limited experience with LKD care; inability to recruit some PCPs such as nurse practitioners.CONCLUSIONSAs co-providers of patient care during the pre-donation phase and the primary drivers of care in the post-donation period, PCPs are positioned to deliver high-quality care to LKDs, contribute to long-term data collection, and potentially improve LKD outcomes. This study outlines challenges PCPs perceive and possible approaches to address them.
理由与目的活体肾供者(LKDs)认为在其捐赠过程中存在护理差距,例如提供者之间的协调和沟通不畅。在他们的捐赠过程中更好地整合初级保健提供者(pcp)可以帮助解决这些差距。我们试图捕捉加拿大pcp的观点,以了解他们在照顾LKDs时感受到的挑战以及他们解决这些挑战的建议。研究设计定性描述性设计。环境与参与者对19名家庭医生进行半结构化深度访谈,直至数据饱和。分析方法:主题分析。结果:参与者强调了当前活体肾脏捐献过程中存在的几个挑战:1)初级实践中LKD护理范围有限;2)捐赠前(被视为促进者)和捐赠后(被视为低障碍和高获取资源,并提供软心理社会支持)的角色和责任不明确;3)对活体肾捐赠过程的理解不一致;4)缺乏支持和资源(患者获得初级保健的可及性、提供者之间的沟通挑战、健康记录传输不良、精神卫生服务的可得性有限、对患者和提供者的财政支持有限)。与会者提出了三个主要建议:1)以务实的方法和按需资源支持pcp;2)让乐龄儿童积极参与照顾他们;3)实施解决LKD护理提供不足的战略(初级保健可及性,开发协作护理模式,改善所有利益相关者之间的沟通,专门和长期的心理社会支持,以及政府优先考虑)。大约一半的样本对LKD护理的经验有限;没有能力招聘到一些pcp,如护士从业人员。结论:作为捐赠前阶段患者护理的共同提供者和捐赠后阶段护理的主要驱动力,pcp定位于为LKD提供高质量的护理,有助于长期数据收集,并有可能改善LKD的预后。本研究概述了pcp所面临的挑战以及解决这些挑战的可能方法。
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引用次数: 0
Trajectories of Experiences and Health-Related Quality of Life of Informal Caregivers of Home and In-Center Dialysis Patients: A Multicenter Longitudinal Cohort Study. 家庭和中心透析患者非正式照顾者的经历轨迹和健康相关生活质量:一项多中心纵向队列研究
IF 13.2 1区 医学 Q1 UROLOGY & NEPHROLOGY Pub Date : 2025-12-05 DOI: 10.1053/j.ajkd.2025.10.012
Esmee Driehuis,Sanne C E Peters,Anneke J Roeterdink,Theodôr J F M Vogels,Namiko A Goto,Marjolein I Broese van Groenou,Renée de Wildt,Friedo W Dekker,Brigit C van Jaarsveld,Alferso C Abrahams
RATIONALE & OBJECTIVEStarting dialysis is challenging for both patients and their informal caregivers. Caregivers help patients adapt and adhere to treatment by providing practical and emotional support, but these responsibilities can take a considerable toll on them. As little is known about how caregiver experiences evolve after dialysis initiation, we aimed to: 1) assess the trajectory of experiences and health-related quality of life (HRQoL) of caregivers of patients on dialysis during the first year of dialysis, 2) assess whether differences in these trajectories exist between caregivers of home dialysis patients and those of in-center hemodialysis (ICHD) patients, and 3) explore in which domains caregivers desire support over time.STUDY DESIGNMulticenter, longitudinal cohort study.SETTING & PARTICIPANTS202 dyads of incident dialysis patients and their adult informal caregivers.EXPOSUREHome dialysis and ICHD.OUTCOMESPositive experiences, caregiver burden, depressive symptoms, and HRQoL.ANALYTICAL APPROACHDescriptive analyses of desired support and linear mixed models to assess and compare trajectories.RESULTSAll but two of the caregiver outcomes deteriorated over the first year of dialysis. The change over time (β, 95%CI) was significant for positive experiences (-1.44, -2.36; -0.51), depressive symptoms (5.20, 3.15; 7.25), physical HRQoL (-5.73, -9.20; -2.26), general HRQoL (-0.13, -0.17; -0.07) and perceived health status (-9.40, -15.12; -3.67), but not for caregiver burden (0.85, -0.02; 1.72) or mental HRQoL (-2.99, -6.93; 0.94). No differences in the trajectories were found between caregivers of patients receiving home dialysis and ICHD, but these groups did differ in desired support.LIMITATIONSSmall sample size of subgroups.CONCLUSIONSInformal caregivers experience significant challenges during the first year of dialysis, marked by a notable decline in positive experiences, physical and general HRQoL, and perceived health status, alongside an increase in depressive symptoms, regardless of dialysis location. These findings underscore the need for targeted support for informal caregivers in dialysis care.
理由与目的开始透析对患者及其非正式护理人员都具有挑战性。护理人员通过提供实际和情感上的支持来帮助患者适应并坚持治疗,但这些责任可能会给他们带来相当大的损失。由于对透析开始后护理者体验的演变知之甚少,我们的目的是:1)评估透析患者第一年护理者的体验轨迹和健康相关生活质量(HRQoL), 2)评估家庭透析患者的护理者与中心血液透析(ICHD)患者的护理者之间是否存在这些轨迹的差异,以及3)探索随着时间的推移,护理者希望在哪些领域获得支持。研究设计:多中心、纵向队列研究。环境与参与者:202对意外透析患者及其成年非正式护理者。家庭透析和ICHD。结果:积极体验、照顾者负担、抑郁症状和HRQoL。分析方法对期望的支持和线性混合模型进行描述性分析,以评估和比较轨迹。结果:在透析治疗的第一年,除两名患者外,其余患者的护理结果均出现恶化。随着时间的推移,积极体验(-1.44,-2.36;-0.51)、抑郁症状(5.20,3.15;7.25)、身体HRQoL(-5.73, -9.20; -2.26)、一般HRQoL(-0.13, -0.17; -0.07)和感知健康状况(-9.40,-15.12;-3.67)的变化显著(β, 95%CI),但对照顾者负担(0.85,-0.02;1.72)或精神HRQoL(-2.99, -6.93; 0.94)的变化不显著。在接受家庭透析和ICHD患者的护理人员之间的轨迹没有发现差异,但这两组在期望的支持方面确实存在差异。局限性:亚组样本量小。结论:在透析的第一年,正规护理人员经历了重大挑战,其标志是积极体验、身体和一般HRQoL以及感知健康状况的显着下降,同时抑郁症状增加,与透析地点无关。这些发现强调需要有针对性地支持透析护理中的非正式护理人员。
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引用次数: 0
In Reply to “Low-Flow Home Hemodialysis Technologies: The Key to Greener Dialysis?” 回复“低流量家庭血液透析技术:绿色透析的关键?”
IF 8.2 1区 医学 Q1 UROLOGY & NEPHROLOGY Pub Date : 2025-12-05 DOI: 10.1053/j.ajkd.2025.10.010
Katherine A. Barraclough PhD , Ben Talbot PhD , Scott McAlister PhD
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引用次数: 0
Blood Pressure–Lowering Agents for Kidney Transplant Recipients: Editorial Summary of a Cochrane Review 肾移植受者的降压药:Cochrane综述的编辑摘要。
IF 8.2 1区 医学 Q1 UROLOGY & NEPHROLOGY Pub Date : 2025-12-04 DOI: 10.1053/j.ajkd.2025.07.022
Patrizia Natale , Suetonia C. Green , Jonathan C. Craig , Giovanni F.M. Strippoli
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引用次数: 0
Selecting Antihypertensive Medications for Kidney Transplant Recipients: Flying Blind 为肾移植受者选择抗高血压药物:盲目飞行。
IF 8.2 1区 医学 Q1 UROLOGY & NEPHROLOGY Pub Date : 2025-12-04 DOI: 10.1053/j.ajkd.2025.09.016
Deepthi Malepati, Paul E. Drawz
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引用次数: 0
Effectiveness and Safety of Apixaban Initiation Following Newly-Diagnosed Atrial Fibrillation in Patients With Kidney Failure on Hemodialysis. 新诊断房颤的肾衰竭血液透析患者阿哌沙班起始治疗的有效性和安全性。
IF 13.2 1区 医学 Q1 UROLOGY & NEPHROLOGY Pub Date : 2025-12-04 DOI: 10.1053/j.ajkd.2025.10.009
Wolfgang C Winkelmayer,Kevin F Erickson,Pascale Khairallah,Mingyue He,Maria E Montez-Rath,Tara I Chang,Jingbo Niu
RATIONALE & OBJECTIVEAtrial fibrillation (AF) is common among patients with kidney failure on hemodialysis (KFHD). We studied the outcomes of apixaban initiation, compared with no initiation of any oral anticoagulation (OAC), among patients with KFHD and newly-diagnosed AF.STUDY DESIGNRetrospective cohort study.SETTING & PARTICIPANTSMedicare-insured patients with KFHD, with newly-diagnosed AF, and without recent OAC use (2014-2019).EXPOSUREInitiation of apixaban treatment versus no OAC initiation within 30 days of an AF diagnosis.OUTCOMESThromboembolic and bleeding events and death within 365 days of follow-up.ANALYTICAL APPROACHPropensity-matched comparison of new apixaban users and OAC non-users implemented using Cox proportional hazards models while accounting for competing risks.RESULTSWithin 30 days of the new diagnosis of AF among 63,300 previously OAC-naïve patients, 4010 initiated apixaban and 59,290 did not initiate any OAC within 30 days. After propensity matching, 3985 apixaban users were well-matched to 3985 OAC non-users on all measured characteristics. Median CHA2DS2-VASc, a multidimensional stroke risk score, was 4 (IQR: 3-5). Apixaban was initiated a median 5 (IQR: 2-12) days after AF and used for a median 59 (IQR: 37-135) days. In intention-to-treat analyses, rates of ischemic stroke were 25% lower (HR=0.75; 95%CI, 0.57-0.97) and those of a composite outcome of thromboembolic events and cardiovascular death were 24% lower (HR=0.76; 95%CI, 0.70-0.83) among apixaban users. Conversely, apixaban users had a 55% higher rate of hemorrhagic stroke (HR=1.55; 95%CI, 1.03-2.33) and a 29% increased rate of clinically important bleeding (HR=1.29; 95%CI, 1.14-1.45). The HR for all-cause mortality was 0.61 (95%CI, 0.56-0.67). Results from as-treated analyses were qualitatively consistent with intent-to-treat analyses, but generally larger in magnitude.LIMITATIONSPotential for residual confounding from unobserved characteristics or informative censoring unaccounted for by competing risk models.CONCLUSIONSAmong patients with KFHD, initiation of apixaban soon after newly-diagnosed AF, compared to no anticoagulation, was associated with lower risks of ischemic stroke, a composite thromboembolic endpoint, and all-cause mortality, but higher rates of clinically meaningful bleeding.
理由与目的房颤(AF)在血液透析肾功能衰竭(KFHD)患者中很常见。我们研究了在KFHD和新诊断房颤患者中,阿哌沙班起始治疗与未起始任何口服抗凝(OAC)治疗的结果。研究对象:2014-2019年,有医疗保险的KFHD患者,新诊断为房颤,近期未使用OAC。在房颤诊断后30天内开始阿哌沙班治疗与不开始OAC治疗。结果:随访365天内发生血栓栓塞和出血事件及死亡。分析方法:在考虑竞争风险的同时,使用Cox比例风险模型对阿哌沙班新使用者和OAC非使用者进行倾向匹配比较。结果在63,300名先前OAC-naïve患者中,在新诊断为房颤的30天内,4010名患者开始使用阿哌沙班,59,290名患者在30天内未使用任何OAC。倾向匹配后,3985名阿哌沙班使用者与3985名OAC非使用者在所有测量特征上都很好地匹配。多维卒中风险评分CHA2DS2-VASc的中位数为4 (IQR: 3-5)。阿哌沙班在房颤后5天(IQR: 2-12)开始使用,使用时间中位数为59天(IQR: 37-135)。在意向治疗分析中,阿哌沙班使用者的缺血性卒中发生率降低25% (HR=0.75; 95%CI, 0.57-0.97),血栓栓塞事件和心血管死亡的复合结局发生率降低24% (HR=0.76; 95%CI, 0.70-0.83)。相反,阿哌沙班使用者出血性卒中发生率增加55% (HR=1.55; 95%CI, 1.03-2.33),临床重要出血发生率增加29% (HR=1.29; 95%CI, 1.14-1.45)。全因死亡率的HR为0.61 (95%CI, 0.56-0.67)。经治疗分析的结果在质量上与意向治疗分析一致,但通常在量级上更大。局限性由于未观察到的特征或竞争性风险模型未解释的信息审查,可能存在残留混淆。结论:在KFHD患者中,与不抗凝相比,在新诊断的房颤后不久开始使用阿哌沙班与缺血性卒中、复合血栓栓塞终点和全因死亡率的风险较低相关,但临床有意义出血的发生率较高。
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引用次数: 0
Thrombotic Microangiopathy During Pregnancy: Role of Soluble Fms-like Tyrosine Kinase-1–Placental Growth Factor Ratios 妊娠期血栓性微血管病变:可溶性fms样酪氨酸激酶-1-胎盘生长因子比值的作用
IF 8.2 1区 医学 Q1 UROLOGY & NEPHROLOGY Pub Date : 2025-12-04 DOI: 10.1053/j.ajkd.2025.09.017
Daan P.C. van Doorn , Salwan Al-Nasiry , Marc E.A. Spaanderman , Jan G.M.C. Damoiseaux , Pieter van Paassen , Sjoerd A.M.E.G. Timmermans
Thrombotic microangiopathies (TMAs) are severe endotheliopathies that can arise in pregnancy and require early recognition. Complement-mediated (C-)TMA should be differentiated from other endotheliopathies of pregnancy because the treatment differs. Here, we report a case of a pregnant woman with acute kidney injury requiring hemodialysis due to C-TMA on the background of a pathogenic C3 variant at 28+5 weeks of gestation. The low soluble Fms-like tyrosine kinase-1 to placental growth factor (sFlt1/PlGF) ratio excluded pre-eclampsia. Eculizumab was started, and therapeutic drug monitoring was applied for optimal dosing. Despite prolonged hemodialysis, fetal well-being was preserved, and delivery was safely postponed till 34+3 weeks of gestation, resulting in a healthy neonate. We also separately report on sFlt1/PlGF ratios measured in a cohort of 11 patients with TMA and coexisting pregnancy. Ten of 11 patients (91%) had low sFlt1/PlGF ratios, excluding pre-eclampsia. Thus, successful pregnancy in women with C-TMA can occur, and sFlt1/PlGF ratios may aid in clarifying the diagnosis and appropriate treatment.
血栓性微血管病变(TMAs)是严重的内皮病变,可在怀孕期间出现,需要早期识别。补体介导的(C-)TMA应与其他妊娠内皮病变区分开来,因为治疗方法不同。在这里,我们报告了一例妊娠28+5周时因致病性C3变异的C-TMA导致急性肾损伤需要血液透析的孕妇。低可溶性fms样酪氨酸激酶-1与胎盘生长因子(sFlt1/PlGF)比值排除先兆子痫。开始使用Eculizumab,并应用治疗药物监测以获得最佳剂量。尽管长时间的血液透析,胎儿的健康得到了保护,分娩被安全推迟到妊娠34+3周,产生了一个健康的新生儿。我们还单独报道了11例TMA合并妊娠患者的sFlt1/PlGF比值。11例患者中有10例(91%)sFlt1/PlGF比例较低,不包括先兆子痫。因此,C-TMA患者可以成功怀孕,sFlt1/PlGF比值可能有助于明确诊断和适当的治疗。
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引用次数: 0
Low-Flow Home Hemodialysis Technologies: The Key to Greener Dialysis? 低流量家庭血液透析技术:绿色透析的关键?
IF 8.2 1区 医学 Q1 UROLOGY & NEPHROLOGY Pub Date : 2025-12-02 DOI: 10.1053/j.ajkd.2025.08.017
Elena Cuadrado-Payán MD, José Jesús Broseta PhD, Aleix Cases PhD
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引用次数: 0
Are Mother Glomeruli in Good or Bad Company? 母肾小球是好还是坏?
IF 8.2 1区 医学 Q1 UROLOGY & NEPHROLOGY Pub Date : 2025-11-29 DOI: 10.1053/j.ajkd.2025.10.008
Georgina Gyarmati
{"title":"Are Mother Glomeruli in Good or Bad Company?","authors":"Georgina Gyarmati","doi":"10.1053/j.ajkd.2025.10.008","DOIUrl":"10.1053/j.ajkd.2025.10.008","url":null,"abstract":"","PeriodicalId":7419,"journal":{"name":"American Journal of Kidney Diseases","volume":"87 2","pages":"Pages 275-277"},"PeriodicalIF":8.2,"publicationDate":"2025-11-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145644985","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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American Journal of Kidney Diseases
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