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Peer Support Interventions for People With CKD: A Scoping Review. 针对慢性肾脏病患者的同伴支持干预:范围界定综述。
IF 9.4 1区 医学 Q1 UROLOGY & NEPHROLOGY Pub Date : 2024-08-21 DOI: 10.1053/j.ajkd.2024.07.007
Meghan J Elliott, Tyrone G Harrison, Shannan Love, Paul E Ronksley, Nancy Verdin, Dwight Sparkes, Caitrin O'Connor, Kate Manns, Sabrina Jassemi, Brenda R Hemmelgarn, Maoliosa Donald
<p><strong>Rationale & objective: </strong>Formalized peer support is a promising approach for addressing the emotional and practical needs of people living with chronic kidney disease (CKD). We systematically identified and summarized peer support interventions studied in individuals with CKD with or without kidney replacement therapy (KRT).</p><p><strong>Sources of evidence: </strong>Search of electronic databases and grey literature sources in March 2023.</p><p><strong>Eligibility criteria: </strong>Studies of any design were eligible if they reported sufficient detail on peer support interventions and outcomes for adults with CKD with or without KRT and/or their caregivers.</p><p><strong>Charting methods: </strong>We extracted information on study and intervention characteristics and reported outcomes using established frameworks. We summarized quantitative data descriptively and qualitative data thematically. Our approach observed the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) extension for scoping reviews.</p><p><strong>Results: </strong>We included 77 studies describing 56 unique peer support interventions. Most reports were program evaluations (39%) or randomized controlled trials (27%) published after 2013. Two-thirds of interventions focused on in-center hemodialysis or mixed CKD populations, and three quarters were integrated within a kidney care clinic or program. Whereas most peer interactions centered on informational support, few programs offered focused support in areas such as transplant navigation or dialysis modality selection. Only one-third of outcomes were assessed against a comparator group, with results suggesting improvements in psychological health with peer support.</p><p><strong>Limitations: </strong>Heterogeneity of included studies; lack of rigorous program evaluation.</p><p><strong>Conclusions: </strong>This review suggests recent growth in peer support programming with a variety of formats and delivery methods to address the diverse needs of people living with kidney disease. Notable gaps in peer support availability for transplant and home dialysis recipients and the lack of rigorous evaluations present opportunities to expand the reach and impact of peer support in the kidney care context.</p><p><strong>Plain-language summary: </strong>Many people with kidney disease struggle with isolation, making decisions about their care, and declines in their mental well-being. Peer support is a way of providing information and emotional support to patients and their loved ones by connecting them with others who have a shared experience of kidney disease. We summarize the features of peer support programs worldwide and the settings in which they have been studied. We searched the medical literature and found 56 unique peer support programs reported in 77 studies. Most studies were from the last 10 years, targeted people receiving hemodialysis, and focused on sharing information about kidney d
理由与目标:正式的同伴支持是解决慢性肾脏病(CKD)患者情感和实际需求的一种有前途的方法。我们旨在系统地识别和总结针对接受或未接受肾脏替代治疗(KRT)的 CKD 患者的同伴支持干预措施:我们检索了 2023 年 3 月的电子数据库和灰色文献资料:任何设计的研究,只要充分详细地报告了针对接受或未接受 KRT 治疗的 CKD 成人和/或其护理人员的同伴支持干预措施和结果,均符合条件:我们使用既定框架提取了有关研究和干预特征的信息,并报告了结果。我们对定量数据进行了描述性总结,对定性数据进行了专题总结。我们的方法遵循了系统综述和荟萃分析首选报告项目(PRISMA)的扩展,用于范围界定综述:结果:我们纳入了 77 项研究,描述了 56 种独特的同伴支持干预措施。大多数报告是在 2013 年之后发表的项目评估(39%)或随机对照试验(27%)。三分之二的干预措施侧重于中心内血液透析或混合型慢性肾脏病人群,四分之三的干预措施整合在肾脏护理诊所或项目中。大多数同伴互动以信息支持为中心,很少有项目在移植导航或透析方式选择等方面提供重点支持。只有三分之一的研究结果是与对比组进行评估的,结果表明同伴支持改善了患者的心理健康:局限性:纳入的研究具有异质性;缺乏严格的项目评估:本综述表明,近来同伴支持计划有了很大发展,其形式和实施方法多种多样,以满足肾病患者的不同需求。在为移植和家庭透析受者提供同伴支持方面存在明显差距,而且缺乏严格的评估,这为扩大同伴支持在肾脏护理领域的覆盖面和影响力提供了机会。
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引用次数: 0
Steps for Stopping Kidney Stones: Physical Activity Triumphant Over Genetics 阻止肾结石的步骤:体育锻炼战胜遗传。
IF 9.4 1区 医学 Q1 UROLOGY & NEPHROLOGY Pub Date : 2024-08-18 DOI: 10.1053/j.ajkd.2024.07.001
Niharika Katkam , Srinivasan Beddhu
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引用次数: 0
Progression of Coronary Artery Calcification and Risk of Clinical Events in CKD: The Chronic Renal Insufficiency Cohort Study. 慢性肾功能不全队列研究:慢性肾功能不全患者冠状动脉钙化进展与临床事件风险
IF 11.3 1区 医学 Q1 UROLOGY & NEPHROLOGY Pub Date : 2024-08-16 DOI: 10.1053/j.ajkd.2024.06.018
Ling Tian, Byron C Jaeger, Julia J Scialla, Matthew J Budoff, Rupal C Mehta, Bernard G Jaar, Georges Saab, Mirela A Dobre, Muredach P Reilly, Daniel J Rader, Raymond R Townsend, James P Lash, Philip Greenland, Tamara Isakova, Joshua D Bundy
<p><strong>Rationale & objective: </strong>Coronary artery calcification (CAC) progresses rapidly in people with chronic kidney disease (CKD) compared with the general population. We studied the association between CAC progression and higher risks of atherosclerotic cardiovascular disease (CVD), congestive heart failure, and all-cause mortality among adults with CKD.</p><p><strong>Study design: </strong>Prospective cohort study.</p><p><strong>Setting & participants: </strong>1,310 participants in the Chronic Renal Insufficiency Cohort (CRIC) Study who had at least 1 CAC scan with no prior history of CVD and with observed or imputed data on changes in CAC over time.</p><p><strong>Exposure: </strong>Observed or imputed CAC progression, categorized as incident CAC among participants with 0 CAC on the baseline scan or progressive CAC when the baseline scan demonstrated CAC and there was an increase in CAC≥50 Agatston units per year.</p><p><strong>Outcome: </strong>Atherosclerotic CVD (myocardial infarction or stroke), congestive heart failure, and all-cause mortality.</p><p><strong>Analytical approach: </strong>Cause-specific Cox proportional hazards regression, stratified by presence of CAC at baseline.</p><p><strong>Results: </strong>A total of 545 participants without and 765 with prevalent CAC at baseline were included. During a mean 3.3 years between CAC assessments, 177 participants (32.5%) without baseline CAC developed incident CAC while 270 participants (35.3%) with baseline CAC developed a≥50 Agatston units per year increase in CAC. After multivariable adjustment, incident CAC was associated with 2.42-fold higher rate of atherosclerotic CVD (95% CI, 1.23-4.79) and 1.82-fold higher rate of all-cause mortality (95% CI, 1.03-3.22). Progressive CAC (≥50 units per year) was not associated with atherosclerotic CVD (HR, 1.42 [95% CI, 0.85-2.35]) but was associated with a 1.73-fold higher rate of all-cause mortality (95% CI, 1.31-2.28). Progressive CAC was not associated with incident heart failure.</p><p><strong>Limitations: </strong>Residual confounding and limited statistical power for some outcomes.</p><p><strong>Conclusions: </strong>Among adults with CKD stages 2-4, CAC progression over a mean 3.3 years was associated with higher risk of atherosclerotic CVD and all-cause mortality. The associations were strongest among participants without CAC at baseline.</p><p><strong>Plain-language summary: </strong>Prior research has shown that coronary artery calcification (CAC) is a marker of higher risk of heart disease and death. Less is known about how changes in CAC over time might affect risk, particularly among patients with kidney disease. In this study, participants with chronic kidney disease who developed CAC or had worsening CAC over time showed higher rates of heart attack, stroke, and death than those who did not develop CAC. These findings support the need for further research on longitudinal changes in CAC as a possible aid to establishin
理由和目标:与普通人群相比,慢性肾脏病(CKD)患者的冠状动脉钙化(CAC)进展迅速。我们研究了慢性肾脏病成人患者的冠状动脉钙化进展与更高的动脉粥样硬化性心血管疾病(CVD)、充血性心力衰竭和全因死亡率之间的关联:前瞻性队列研究:慢性肾功能不全队列(CRIC)研究中的1310名参与者,他们至少接受过一次CAC扫描,既往无心血管疾病史,并观察或推算出CAC随时间变化的数据:观察到的或估算的 CAC 进展,在基线扫描中 CAC 为零的参与者中被归类为事件性 CAC,或在基线扫描显示 CAC 且每年 CAC 增加≥50 阿加特斯通单位时被归类为进展性 CAC:动脉粥样硬化性心血管疾病(心肌梗死或中风)、充血性心力衰竭和全因死亡率:分析方法:特定病因的 Cox 比例危险回归,根据基线时是否存在 CAC 进行分层:结果:共纳入了 545 名基线时无 CAC 的参与者和 765 名有 CAC 的参与者。在两次CAC评估之间的平均3.3年中,177名(32.5%)无基线CAC的参与者出现了CAC事件,而270名(35.3%)有基线CAC的参与者的CAC每年增加≥50阿加斯顿单位。经多变量调整后,事件性 CAC 与动脉粥样硬化性心血管疾病发病率增加 2.42 倍(95% 置信区间 [CI]:1.23-4.79)和全因死亡率增加 1.82 倍(95% 置信区间:1.03-3.22)有关。进行性 CAC(每年≥50 个单位)与动脉粥样硬化性心血管疾病无关(危险比 [HR]:1.42;95% CI:0.85-2.35),但与全因死亡率增加 1.73 倍有关(95% CI:1.31-2.28)。渐进性CAC与心力衰竭事件无关:局限性:残留混杂因素和某些结果的统计能力有限:结论:在患有慢性肾脏病2-4期的成年人中,CAC在平均3.3年内的进展与较高的动脉粥样硬化性心血管疾病风险和全因死亡率有关。基线时无CAC的参与者的相关性最强。
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引用次数: 0
Effect of Dual RAAS Blockade and Intensive BP Lowering on Risk of End-Stage Kidney Disease and Death in Autosomal Dominant Polycystic Kidney Disease: Long-term Follow-up of the HALT-PKD Trials. 双重 RAAS 阻断和强化降压对常染色体显性遗传多囊肾病终末期肾病和死亡风险的影响:HALT-PKD试验的长期随访。
IF 9.4 1区 医学 Q1 UROLOGY & NEPHROLOGY Pub Date : 2024-08-16 DOI: 10.1053/j.ajkd.2024.06.020
Elaine Ku, Timothy P Copeland, Charles E McCulloch, Kaleab Z Abebe, Michel Chonchol, Ronald D Perrone, Frederic F Rahbari-Oskoui, Alan S L Yu, Theodore Steinman, Arlene Chapman, Mark J Sarnak
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引用次数: 0
Super-Resolution Ultrasound to Assess Kidney Vascular Changes in Humans With Kidney Disease. 用超分辨率超声波评估肾病患者的肾血管变化
IF 9.4 1区 医学 Q1 UROLOGY & NEPHROLOGY Pub Date : 2024-08-16 DOI: 10.1053/j.ajkd.2024.06.021
Qiyang Chen, Michael W George, Brenda McMahon, Joshua A Rosenthal, Kang Kim, Roderick J Tan
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引用次数: 0
The Need for Culturally Tailored CKD Education in Older Latino Patients and Their Families. 针对拉丁裔老年患者及其家庭开展符合其文化背景的慢性肾脏病教育的必要性。
IF 9.4 1区 医学 Q1 UROLOGY & NEPHROLOGY Pub Date : 2024-08-09 DOI: 10.1053/j.ajkd.2024.06.015
Thalia Porteny, Kristen Kennefick, Mary Lynch, Angie M Velasquez, Kelli Collins Damron, Sylvia Rosas, Jennifer Allen, Daniel E Weiner, Sean Kalloo, Katherine Rizzolo, Keren Ladin

Older Latino adults (aged 65+years) comprise the fastest growing minoritized group among the older population in the United States and experience a disproportionate burden of kidney failure as well as disparities in kidney care compared with non-Hispanic White individuals. Despite significant need and barriers uniquely faced by this population, few educational resources or decision aids are available to meet the language and cultural needs of Latino patients. Decision aids are designed to improve knowledge and empower individuals to engage in shared decision making and have been shown to improve decisional quality and goal-concordant care among older patients with chronic kidney disease (CKD). In this commentary, we examine the barriers faced by older Latino people with CKD who must make dialysis initiation decisions. We conclude that there is a need for culturally concordant decision aids tailored for older Latino patients with CKD to overcome barriers in access to care and improve patient-centered care for older Latino CKD patients.

拉美裔老年人(65 岁以上)是美国老年人口中增长最快的少数群体,与非西班牙裔白人相比,他们承受着过重的肾衰竭负担,在肾脏护理方面也存在差异。尽管拉美裔患者有很大的需求,也面临着独特的障碍,但能满足拉美裔患者语言和文化需求的教育资源或辅助决策工具却寥寥无几。决策辅助工具的设计目的是增进知识,增强个人参与共同决策的能力,并已证明可提高决策质量和老年慢性肾脏病患者的目标一致性护理。在这篇评论中,我们探讨了患有慢性肾脏病的拉丁裔老年患者在必须做出透析启动决定时所面临的障碍。我们的结论是,有必要为年长的拉美裔 CKD 患者量身定制文化和谐的决策辅助工具,以克服获得护理的障碍,改善年长的拉美裔 CKD 患者以患者为中心的护理。
{"title":"The Need for Culturally Tailored CKD Education in Older Latino Patients and Their Families.","authors":"Thalia Porteny, Kristen Kennefick, Mary Lynch, Angie M Velasquez, Kelli Collins Damron, Sylvia Rosas, Jennifer Allen, Daniel E Weiner, Sean Kalloo, Katherine Rizzolo, Keren Ladin","doi":"10.1053/j.ajkd.2024.06.015","DOIUrl":"10.1053/j.ajkd.2024.06.015","url":null,"abstract":"<p><p>Older Latino adults (aged 65+years) comprise the fastest growing minoritized group among the older population in the United States and experience a disproportionate burden of kidney failure as well as disparities in kidney care compared with non-Hispanic White individuals. Despite significant need and barriers uniquely faced by this population, few educational resources or decision aids are available to meet the language and cultural needs of Latino patients. Decision aids are designed to improve knowledge and empower individuals to engage in shared decision making and have been shown to improve decisional quality and goal-concordant care among older patients with chronic kidney disease (CKD). In this commentary, we examine the barriers faced by older Latino people with CKD who must make dialysis initiation decisions. We conclude that there is a need for culturally concordant decision aids tailored for older Latino patients with CKD to overcome barriers in access to care and improve patient-centered care for older Latino CKD patients.</p>","PeriodicalId":7419,"journal":{"name":"American Journal of Kidney Diseases","volume":" ","pages":""},"PeriodicalIF":9.4,"publicationDate":"2024-08-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141911354","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Explaining International Trends in Mortality on Hemodialysis Through Changes in Hemodialysis Practices in the Dialysis Outcomes and Practice Patterns Study (DOPPS). 通过透析结果和实践模式研究 (DOPPS) 中血液透析实践的变化来解释血液透析死亡率的国际趋势。
IF 9.4 1区 医学 Q1 UROLOGY & NEPHROLOGY Pub Date : 2024-08-09 DOI: 10.1053/j.ajkd.2024.06.017
Keith P McCullough, Hal Morgenstern, Hugh C Rayner, Friedrich K Port, Michel Y Jadoul, Tadao Akizawa, Ronald L Pisoni, William H Herman, Bruce M Robinson
<p><strong>Rationale & objective: </strong>Case-mix adjusted hemodialysis mortality has decreased since 1998. Many factors that influence mortality may have contributed to this trend, and these associations may differ by continental region. We studied changes in hemodialysis facility practices over time and their potential role in mediating changes in patient survival.</p><p><strong>Study design: </strong>Observational prospective cohort study.</p><p><strong>Setting & participants: </strong>Adult hemodialysis patients treated in 500 hemodialysis facilities participating in the Dialysis Outcomes and Practice Patterns Study (DOPPS) between 1999 and 2015 in the United States, Japan, and 4 European countries: Germany, Italy, Spain, and the United Kingdom.</p><p><strong>Predictors: </strong>Four practice measures at each facility: the percentages of patients with Kt/V≥1.2, interdialytic weight gain [IDWG]<5.7%, phosphorus<6mg/dL, and using arteriovenous fistulas (AVFs).</p><p><strong>Outcome: </strong>Patient survival.</p><p><strong>Analytical approach: </strong>Mediation analyses, adjusted for case mix, were conducted using 3-year study phase as the exposure and facility practice measures as potential mediators.</p><p><strong>Results: </strong>In Europe, we observed a 13% improvement in overall case-mix adjusted survival per decade. Trends in facility practice measures, especially Kt/V and phosphorus, explained 10% improvement in case-mix survival per decade, representing 77% (10% explained of 13% improvement) of the observed improvement. In Japan, 73% of the observed 12%/decade improvement in case-mix adjusted survival could be attributed to facility practices, especially Kt/V and IDWG. In the United States, 56% of the observed 47%/decade improvement in case-mix adjusted survival could be attributed to facility practices, especially AVF use and phosphorus control.</p><p><strong>Limitations: </strong>Unmeasured changes in the characteristics of the patient population over this period may confound the observed associations.</p><p><strong>Conclusions: </strong>The improvements in adjusted hemodialysis patient survival in Europe, Japan, and the United States from 1999 to 2015 can be largely explained by improvements in specific facility practices. Future changes in patient survival may be responsive to further evolution in the implementation of common clinical practices.</p><p><strong>Plain-language summary: </strong>Case-mix adjusted survival of patients treated with hemodialysis has improved over the last 2 decades in the United States, Japan, and Europe. Some of this improvement can be explained by region-specific changes in 4 dialysis practices, namely increases in the proportions of patients achieving (1) Kt/V≥1.2, (2) serum phosphorus levels<6mg/dL, (3) interdialytic weight gain<5.7% of body weight, and/or (4) use of arteriovenous fistulas as vascular access, with the magnitude varying according to region-specific trends in these practices. These
理由和目标:自 1998 年以来,病例组合调整后的血液透析死亡率有所下降。许多影响死亡率的因素可能促成了这一趋势,而且这些关联可能因大陆地区而异。我们研究了血液透析设施操作随时间推移而发生的变化,以及这些变化对患者生存率变化的潜在影响:观察性前瞻性队列研究:研究设计:观察性前瞻性队列研究。研究地点和参与者:1999年至2015年期间在美国、日本和4个欧洲国家参与透析结果实践模式研究(DOPPS)的500家血液透析机构接受治疗的成人血液透析患者:预测因素:每个机构的四项实践指标:Kt/V>1.2 的患者百分比、透析间期体重增加 [IDWG]:分析方法分析方法:以3年研究阶段为暴露因子,以医疗机构的实践措施为潜在因子,对病例组合进行调整后进行中介分析:在欧洲,我们观察到病例组合调整后的总体生存率每十年提高了 13%。设施实践措施的趋势,尤其是 Kt/V 和磷,解释了每十年病例组合存活率提高 10%的原因,占观察到的提高的 77%(13% 提高中的 10%)。在日本,观察到的病例组合调整后存活率每十年 12% 的改善中有 73% 可归因于设施实践,尤其是 Kt/V 和 IDWG。在美国,观察到的病例组合调整后存活率每十年 47% 的改善中,56% 可归因于设备操作,尤其是 AV 造瘘器的使用和磷控制:局限性:在此期间,未测量的患者群体特征变化可能会混淆观察到的关联:结论:从 1999 年到 2015 年,欧洲、日本和美国调整后的血液透析患者存活率有所提高,这在很大程度上归因于特定设备操作的改进。未来患者生存率的变化可能会随着常见临床实践的进一步发展而变化。
{"title":"Explaining International Trends in Mortality on Hemodialysis Through Changes in Hemodialysis Practices in the Dialysis Outcomes and Practice Patterns Study (DOPPS).","authors":"Keith P McCullough, Hal Morgenstern, Hugh C Rayner, Friedrich K Port, Michel Y Jadoul, Tadao Akizawa, Ronald L Pisoni, William H Herman, Bruce M Robinson","doi":"10.1053/j.ajkd.2024.06.017","DOIUrl":"10.1053/j.ajkd.2024.06.017","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Rationale & objective: &lt;/strong&gt;Case-mix adjusted hemodialysis mortality has decreased since 1998. Many factors that influence mortality may have contributed to this trend, and these associations may differ by continental region. We studied changes in hemodialysis facility practices over time and their potential role in mediating changes in patient survival.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Study design: &lt;/strong&gt;Observational prospective cohort study.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Setting & participants: &lt;/strong&gt;Adult hemodialysis patients treated in 500 hemodialysis facilities participating in the Dialysis Outcomes and Practice Patterns Study (DOPPS) between 1999 and 2015 in the United States, Japan, and 4 European countries: Germany, Italy, Spain, and the United Kingdom.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Predictors: &lt;/strong&gt;Four practice measures at each facility: the percentages of patients with Kt/V≥1.2, interdialytic weight gain [IDWG]&lt;5.7%, phosphorus&lt;6mg/dL, and using arteriovenous fistulas (AVFs).&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Outcome: &lt;/strong&gt;Patient survival.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Analytical approach: &lt;/strong&gt;Mediation analyses, adjusted for case mix, were conducted using 3-year study phase as the exposure and facility practice measures as potential mediators.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;In Europe, we observed a 13% improvement in overall case-mix adjusted survival per decade. Trends in facility practice measures, especially Kt/V and phosphorus, explained 10% improvement in case-mix survival per decade, representing 77% (10% explained of 13% improvement) of the observed improvement. In Japan, 73% of the observed 12%/decade improvement in case-mix adjusted survival could be attributed to facility practices, especially Kt/V and IDWG. In the United States, 56% of the observed 47%/decade improvement in case-mix adjusted survival could be attributed to facility practices, especially AVF use and phosphorus control.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Limitations: &lt;/strong&gt;Unmeasured changes in the characteristics of the patient population over this period may confound the observed associations.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Conclusions: &lt;/strong&gt;The improvements in adjusted hemodialysis patient survival in Europe, Japan, and the United States from 1999 to 2015 can be largely explained by improvements in specific facility practices. Future changes in patient survival may be responsive to further evolution in the implementation of common clinical practices.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Plain-language summary: &lt;/strong&gt;Case-mix adjusted survival of patients treated with hemodialysis has improved over the last 2 decades in the United States, Japan, and Europe. Some of this improvement can be explained by region-specific changes in 4 dialysis practices, namely increases in the proportions of patients achieving (1) Kt/V≥1.2, (2) serum phosphorus levels&lt;6mg/dL, (3) interdialytic weight gain&lt;5.7% of body weight, and/or (4) use of arteriovenous fistulas as vascular access, with the magnitude varying according to region-specific trends in these practices. These ","PeriodicalId":7419,"journal":{"name":"American Journal of Kidney Diseases","volume":" ","pages":""},"PeriodicalIF":9.4,"publicationDate":"2024-08-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141911352","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Patient, Parental, and Health Professional Perspectives on Growth in Children With CKD. 患者、家长和医务人员对慢性肾脏病患儿成长的看法。
IF 9.4 1区 医学 Q1 UROLOGY & NEPHROLOGY Pub Date : 2024-08-09 DOI: 10.1053/j.ajkd.2024.06.016
Justin G Wu, Chandana Guha, Anastasia Hughes, Luca G Torrisi, Jonathan C Craig, Aditi Sinha, Allison Dart, Allison A Eddy, Detlef Bockenhauer, Hui-Kim Yap, Jaap Groothoff, Stephen I Alexander, Susan L Furth, Susan Samuel, Simon A Carter, Amanda Walker, Joshua Kausman, Allison Jaure
<p><strong>Rationale & objective: </strong>Growth failure is a common problem among children with chronic kidney disease (CKD). Reduced height is associated with psychosocial burden, social stigma, and impaired quality of life. This study describes the aspects of growth impairment that are most impactful from the perspectives of children with CKD, their parents, and health professionals.</p><p><strong>Study design: </strong>Qualitative study.</p><p><strong>Settings & participants: </strong>120 children with CKD (aged 8-21 years), 250 parents, and 445 health professionals from 53 countries who participated in 16 focus groups, 2 consensus workshops, and a Delphi survey.</p><p><strong>Analytical approach: </strong>A thematic analysis of all qualitative data concerning growth from the Standardized Outcomes in Nephrology-Children and Adolescents (SONG-Kids) initiative.</p><p><strong>Results: </strong>We identified 5 themes: diminishing psychological well-being (compared to and judged by peers, tired of explaining to others, damaging self-esteem), constrained life participation and enjoyment (deprived of normal school experiences, excluded from sports or competing at a disadvantage, impaired quality of life in adulthood); grappling with impacts of symptoms and treatment (difficulty understanding short stature and accessing help, lack of appetite, uncertainty regarding bone pains, medication side effects, burden of growth hormone treatment); facilitating timely interventions and optimizing outcomes (early indicator of disease, assessing management, maximizing transplant outcomes, minimizing morbidity); and keeping growth and health priorities in perspective (quality of life and survival of utmost priority, achieved adequate height).</p><p><strong>Limitations: </strong>Only English-speaking participants were included.</p><p><strong>Conclusions: </strong>Impaired growth may diminish psychological well-being, self-esteem, and participation in daily activities for children with CKD. Balancing different treatments that can affect growth complicates decision making. These findings may inform the psychosocial support needed by children with CKD and their caregivers to address concerns about growth.</p><p><strong>Plain-language summary: </strong>Children with chronic kidney disease (CKD) are often much shorter than their peers and may experience poorer mental health and quality of life. To understand the specific important issues on how growth impairment affects these children, we collected qualitative data from the Standardized Outcomes in Nephrology-Children and Adolescents (SONG-Kids) initiative and analyzed perspectives on growth from patients, parents, and health professionals. These data revealed impaired psychological health, reduced enjoyment during school and sports, difficulty dealing with medication side effects and growth hormone treatment, and concerns related to tracking health status and kidney transplant outcomes. These findings may inform the p
理由和目标:生长发育迟缓是慢性肾脏病(CKD)患儿的常见问题。身高降低与社会心理负担、社会耻辱感和生活质量下降有关。本研究旨在从慢性肾脏病患儿、其父母和医疗专业人员的角度,描述生长障碍中影响最大的方面:定性研究:来自 53 个国家的 120 名慢性肾脏病儿童(8-21 岁)、250 名家长和 445 名医疗专业人员参加了 16 个焦点小组、两次共识研讨会和一次德尔菲调查:分析方法:对 "肾脏病标准化结果--儿童和青少年"(SONG-Kids)计划中有关成长的所有定性数据进行专题分析:我们确定了五个主题:心理健康水平下降(与同龄人相比和被同龄人评判、厌倦向他人解释、自尊心受损)、生活参与和享受受到限制(被剥夺正常的学校经历、被排除在体育运动或竞争劣势之外、成年后生活质量受损);应对症状和治疗带来的影响(难以理解身材矮小和寻求帮助、食欲不振、对骨痛的不确定性、药物副作用、生长激素治疗的负担);促进及时干预和优化结果(疾病的早期指标、评估管理、最大限度地提高移植结果、最大限度地降低发病率);以及保持对生长和健康的优先考虑(生活质量和生存是重中之重,达到足够的身高)。局限性:仅包括讲英语的参与者:对于患有慢性肾脏病的儿童来说,发育受损可能会降低他们的心理健康水平、自尊心以及对日常活动的参与度。平衡各种可能影响生长的治疗方法使决策变得复杂。这些发现可为慢性肾脏病患儿及其照顾者提供所需的社会心理支持,以解决他们对生长发育的担忧。
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引用次数: 0
Representation of Low- and Middle-Income Countries in CKD Drug Trials: A Systematic Review. 中低收入国家在慢性肾脏病药物试验中的代表性:系统回顾。
IF 9.4 1区 医学 Q1 UROLOGY & NEPHROLOGY Pub Date : 2024-08-06 DOI: 10.1053/j.ajkd.2024.06.012
Gabriel Cojuc-Konigsberg, Alberto Guijosa, Alberto Moscona-Nissan, Alberto Nordmann-Gomes, Vianca Anabel Canaviri-Flores, Alan Braverman-Poyastro, Regina de la Fuente-Ramírez, Denisse Tinajero-Sánchez, Alejandra de Las Fuentes Cepeda, Andrés Noyola-Pérez, Rafael Lozano, Ricardo Correa-Rotter, Juan C Ramírez-Sandoval
<p><strong>Rationale & objective: </strong>Almost 80% of individuals with chronic kidney disease (CKD) reside in low- and middle-income countries (LMICs) and are potentially underrepresented in randomized controlled clinical trials (RCTs). We assessed the global distribution of RCTs comparing pharmacological treatments for CKD over the past 2 decades, as well as the magnitude and evolution of participation by LMICs.</p><p><strong>Study design: </strong>Systematic review.</p><p><strong>Setting & study populations: </strong>RCTs evaluating pharmacological interventions in adults with CKD.</p><p><strong>Selection criteria for studies: </strong>RCTs published between 2003-2023 and indexed in MEDLINE.</p><p><strong>Data extraction: </strong>Each trial was reviewed and extracted independently by 2 investigators with disagreements settled by consensus or a third reviewer.</p><p><strong>Analytical approach: </strong>RCT participation of World Bank-defined income groups and geographic regions were described, and the representation indices (RI) according to RCT participants and estimated CKD prevalences were calculated. RCTs were also categorized as global, regional, or national in scope.</p><p><strong>Results: </strong>Among 7,760 identified studies, we included 1,366 RCTs conducted in 84 countries with 301,158 participants. National, regional, and global RCTs represented 85.4%, 3.5%, and 11.1% of studies, respectively. LMICs were included in 34.7% of RCTs. No RCTs included participants from low-income countries, and lower-middle-income countries participated in 13.2%. Of participants from RCTs with available information, 25.4% (n=64,843 of 255,237) were from LMICs. According to the RI, 6 LMICs were overrepresented (>1.25), 7 were adequately represented (0.75-1.25), and 26 were underrepresented (<0.75). Most global CKD RCTs (80.2%) included LMICs; however, LMIC participants constituted only 32.9% of the global trial population. We observed a positive trend in LMIC inclusion over time, rising from 22.9% (n=71of 310) in 2003-2007 to 45.5% (n=140of 308) in 2018-2023.</p><p><strong>Limitations: </strong>The use of an income-group dichotomy, exclusion of nonrandomized studies of intervention, and studies identified in 1 database.</p><p><strong>Conclusions: </strong>Despite an increase in participation over the past 2 decades, individuals with CKD from LMICs remain significantly underrepresented in RCTs. These findings suggest that increased efforts are warranted to increase LMIC representation in pharmacological CKD RCTs.</p><p><strong>Plain-language summary: </strong>Chronic kidney disease (CKD) substantially affects people from low- and middle-income countries (LMICs). However, the participation of these countries in randomized controlled trials (RCTs) remains uncertain. To assess the global distribution and representation of these countries in kidney disease research, we reviewed 1,366 CKD drug RCTs published from 2003-2023, conducted in 84 countries involv
理由与目标:近80%的慢性肾脏病(CKD)患者居住在中低收入国家(LMIC),他们在随机对照临床试验(RCT)中的代表性可能不足。我们评估了过去二十年中比较 CKD 药物治疗的 RCT 的全球分布情况,以及中低收入国家的参与程度和演变情况:研究设计:系统回顾:研究选择标准:2003-2023 年间发表的 RCT:研究的选择标准:2003-2023年间发表的、被MEDLINE收录的RCT:每项试验均由两名研究人员独立审查和提取。分析方法:对世界银行定义的收入群体和地理区域的 RCT 参与情况进行了描述,并根据 RCT 参与者和估计的 CKD 患病率计算了代表性指数 (RI)。研究还被分为全球、地区或国家范围:在确定的 7,760 项研究中,我们纳入了在 84 个国家进行的 1,366 项 RCT,共有 301,158 名参与者。国家、地区和全球 RCT 研究分别占 85.4%、3.5% 和 11.1%。34.7%的 RCT 纳入了低收入国家和地区。没有一项研究纳入了低收入国家的参与者,13.2%的研究纳入了中低收入国家的参与者。在有资料可查的 RCT 中,25.4%(n=64,843/255,237)的参与者来自低中等收入国家。根据 RI,6 个低收入国家/地区代表性过高(>1.25),7 个国家/地区代表性充足(0.75-1.25),26 个国家/地区代表性不足(局限性:局限性:使用了收入组二分法,排除了非随机干预研究,以及在一个数据库中确定的研究:尽管过去二十年中参与研究的人数有所增加,但来自低收入和中等收入国家的慢性肾脏病患者在 RCT 中的代表性仍然明显不足。这些研究结果表明,有必要加大努力,增加低地低收入国家在药物治疗 CKD RCT 中的代表性。
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引用次数: 0
Continuous Kidney Replacement Therapy in Pediatric Intensive Care Unit: Little People, Big Gaps 儿科重症监护室的持续肾脏替代疗法:小人物,大差距。
IF 9.4 1区 医学 Q1 UROLOGY & NEPHROLOGY Pub Date : 2024-08-02 DOI: 10.1053/j.ajkd.2024.06.010
Jia Xin Huang , Jessica Ashley J. Williams , Raymond K. Hsu
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引用次数: 0
期刊
American Journal of Kidney Diseases
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