Pub Date : 2024-05-30DOI: 10.1038/s44220-024-00265-7
John A. Schneider, Darnell N. Motley, L. Philip Schumm, Jade Pagkas-Bather
Black sexually minoritized men (BSMM), Black men who identify as part of a sexual minority group, are disproportionately affected by HIV in the United States. There is a need to shift existing reductive research paradigms to focus on within-group variation, in order to include BSMM who are living with and without HIV.
{"title":"Shifting BSMM research paradigms in the context of HIV status-neutral care continuums","authors":"John A. Schneider, Darnell N. Motley, L. Philip Schumm, Jade Pagkas-Bather","doi":"10.1038/s44220-024-00265-7","DOIUrl":"10.1038/s44220-024-00265-7","url":null,"abstract":"Black sexually minoritized men (BSMM), Black men who identify as part of a sexual minority group, are disproportionately affected by HIV in the United States. There is a need to shift existing reductive research paradigms to focus on within-group variation, in order to include BSMM who are living with and without HIV.","PeriodicalId":74247,"journal":{"name":"Nature mental health","volume":"2 6","pages":"632-633"},"PeriodicalIF":0.0,"publicationDate":"2024-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141308927","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-05-23DOI: 10.1038/s44220-024-00252-y
Brady D. Hanshaw, Mark Fusunyan, Chase T. M. Anderson, Jack L. Turban
Although research on psychedelic-assisted therapy (PAT) is rapidly expanding, the clinical trial literature has been criticized for its underrepresentation of sexual and gender minority (SGM) and racial communities. Accordingly, there is a pressing need to study the outcomes of PAT in minoritized communities and its effects on the mental health disparities among SGM communities. Here we discuss the potential relevance of minority stress theory and its principles as they relate to PAT for SGM communities. Furthermore, we propose a theoretical framework integrating minority stress theory and its extensions with prominent models of psychedelic action, highlighting the potential of PAT to plasticize entrenched cognitive and behavioral patterns associated with minority stress. Future research should explore the mechanisms by which PAT may interact with minority stress processes and the potential benefits of SGM-affirmative adaptations of PAT. The integration of minority stress theory into PAT research may enrich our understanding of its therapeutic mechanisms while tailoring a promising intervention to individuals disproportionately excluded from effective care. This Perspective discusses the importance of increasing access to psychedelic-assisted therapy to sexual and gender minorities and proposes a theoretical framework integrating minority stress theory to inform the research and guide study design.
尽管有关迷幻辅助疗法（PAT）的研究正在迅速扩展，但临床试验文献却因其对性与性别少数群体（SGM）和种族群体的代表性不足而饱受批评。因此，迫切需要研究 PAT 在少数群体中的疗效及其对 SGM 群体心理健康差异的影响。在此，我们将讨论少数群体压力理论及其原则与 SGM 群体的 PAT 的潜在相关性。此外，我们还提出了一个理论框架，将少数群体压力理论及其延伸理论与著名的迷幻药作用模型相结合，强调了 PAT 对与少数群体压力相关的根深蒂固的认知和行为模式的可塑性。未来的研究应探索 PAT 与少数群体压力过程相互作用的机制，以及 PAT 的 SGM 肯定适应性的潜在益处。将少数群体压力理论整合到 PAT 研究中可能会丰富我们对其治疗机制的理解，同时为被过度排除在有效护理之外的个人量身定制一种有前景的干预措施。本视角讨论了增加性少数群体和性别少数群体获得迷幻辅助疗法的机会的重要性，并提出了一个融合少数群体压力理论的理论框架，为研究提供信息并指导研究设计。
{"title":"Psychedelic-assisted therapy among sexual and gender minority communities","authors":"Brady D. Hanshaw, Mark Fusunyan, Chase T. M. Anderson, Jack L. Turban","doi":"10.1038/s44220-024-00252-y","DOIUrl":"10.1038/s44220-024-00252-y","url":null,"abstract":"Although research on psychedelic-assisted therapy (PAT) is rapidly expanding, the clinical trial literature has been criticized for its underrepresentation of sexual and gender minority (SGM) and racial communities. Accordingly, there is a pressing need to study the outcomes of PAT in minoritized communities and its effects on the mental health disparities among SGM communities. Here we discuss the potential relevance of minority stress theory and its principles as they relate to PAT for SGM communities. Furthermore, we propose a theoretical framework integrating minority stress theory and its extensions with prominent models of psychedelic action, highlighting the potential of PAT to plasticize entrenched cognitive and behavioral patterns associated with minority stress. Future research should explore the mechanisms by which PAT may interact with minority stress processes and the potential benefits of SGM-affirmative adaptations of PAT. The integration of minority stress theory into PAT research may enrich our understanding of its therapeutic mechanisms while tailoring a promising intervention to individuals disproportionately excluded from effective care. This Perspective discusses the importance of increasing access to psychedelic-assisted therapy to sexual and gender minorities and proposes a theoretical framework integrating minority stress theory to inform the research and guide study design.","PeriodicalId":74247,"journal":{"name":"Nature mental health","volume":"2 6","pages":"636-644"},"PeriodicalIF":0.0,"publicationDate":"2024-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141104573","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-05-23DOI: 10.1038/s44220-024-00246-w
S. Smout, K. E. Champion, S. O’Dean, M. Teesson, L. A. Gardner, N. C. Newton
Mental disorders are a leading cause of disease burden worldwide. As onset typically occurs in adolescence, prevention during this period is critical. The Health4Life-school-based multiple health behavior change (MHBC) intervention targets six lifestyle risk factors: diet, sleep, physical activity, screentime, alcohol use and smoking. Health4Life has been evaluated in a cluster-randomized controlled trial in 71 Australian schools (6,639 grade seven students). This study presents intervention effects on secondary outcomes of depressive, anxiety and psychological distress symptoms. Generalized linear mixed-effect analyses of data from baseline, post-intervention (7 weeks), 12 months and 24 months showed that the Health4Life intervention was no more effective than an active control in reducing depressive, anxiety or psychological distress symptoms at a 24 or 12 month follow-up; however, there were short-term benefits for psychological distress and depressive symptoms immediately post-intervention. This study offers new evidence that multiple health behavior change interventions may improve adolescent mental health, but future research should explore methods to address anxiety and sustain effects over the longer term. A priori ANZCTR trial registration: ACTRN12619000431123. The authors present the secondary outcomes from a cluster-randomized controlled trial of the Health4Life multiple health behavior change intervention. The intervention showed short-term benefits for distress and depressive symptoms but was not more effective than an active control condition.
{"title":"Anxiety, depression and distress outcomes from the Health4Life intervention for adolescent mental health: a cluster-randomized controlled trial","authors":"S. Smout, K. E. Champion, S. O’Dean, M. Teesson, L. A. Gardner, N. C. Newton","doi":"10.1038/s44220-024-00246-w","DOIUrl":"10.1038/s44220-024-00246-w","url":null,"abstract":"Mental disorders are a leading cause of disease burden worldwide. As onset typically occurs in adolescence, prevention during this period is critical. The Health4Life-school-based multiple health behavior change (MHBC) intervention targets six lifestyle risk factors: diet, sleep, physical activity, screentime, alcohol use and smoking. Health4Life has been evaluated in a cluster-randomized controlled trial in 71 Australian schools (6,639 grade seven students). This study presents intervention effects on secondary outcomes of depressive, anxiety and psychological distress symptoms. Generalized linear mixed-effect analyses of data from baseline, post-intervention (7 weeks), 12 months and 24 months showed that the Health4Life intervention was no more effective than an active control in reducing depressive, anxiety or psychological distress symptoms at a 24 or 12 month follow-up; however, there were short-term benefits for psychological distress and depressive symptoms immediately post-intervention. This study offers new evidence that multiple health behavior change interventions may improve adolescent mental health, but future research should explore methods to address anxiety and sustain effects over the longer term. A priori ANZCTR trial registration: ACTRN12619000431123. The authors present the secondary outcomes from a cluster-randomized controlled trial of the Health4Life multiple health behavior change intervention. The intervention showed short-term benefits for distress and depressive symptoms but was not more effective than an active control condition.","PeriodicalId":74247,"journal":{"name":"Nature mental health","volume":"2 7","pages":"818-827"},"PeriodicalIF":0.0,"publicationDate":"2024-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.com/articles/s44220-024-00246-w.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141106074","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-05-20DOI: 10.1038/s44220-024-00254-w
Jamie Morgan
{"title":"Reporting the challenges and negative impacts of lived experience involvement","authors":"Jamie Morgan","doi":"10.1038/s44220-024-00254-w","DOIUrl":"10.1038/s44220-024-00254-w","url":null,"abstract":"","PeriodicalId":74247,"journal":{"name":"Nature mental health","volume":"2 6","pages":"631-631"},"PeriodicalIF":0.0,"publicationDate":"2024-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141121519","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-05-17DOI: 10.1038/s44220-024-00257-7
Arun J. Thirunavukarasu, Jessica O’Logbon
Generative artificial intelligence (AI), exemplified by large language models such as ChatGPT, shows promise in mental health practice, aiding research, training and therapy. However, bias, inaccuracy and trust issues necessitate careful integration with human expertise.
{"title":"The potential and perils of generative artificial intelligence in psychiatry and psychology","authors":"Arun J. Thirunavukarasu, Jessica O’Logbon","doi":"10.1038/s44220-024-00257-7","DOIUrl":"10.1038/s44220-024-00257-7","url":null,"abstract":"Generative artificial intelligence (AI), exemplified by large language models such as ChatGPT, shows promise in mental health practice, aiding research, training and therapy. However, bias, inaccuracy and trust issues necessitate careful integration with human expertise.","PeriodicalId":74247,"journal":{"name":"Nature mental health","volume":"2 7","pages":"745-746"},"PeriodicalIF":0.0,"publicationDate":"2024-05-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140963303","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-05-14DOI: 10.1038/s44220-024-00255-9
Kevin W. Hoffman, Kate T. Tran, Tyler M. Moore, Mārtiņš M. Gataviņš, Elina Visoki, Ohyoon Kwon, Grace E. DiDomenico, Barbara H. Chaiyachati, Laura M. Schultz, Laura Almasy, Matthew R. Hayes, Nikolaos P. Daskalakis, Ran Barzilay
Allostatic load (AL) is the cumulative ‘wear and tear’ on the body due to chronic adversity. We tested the poly-environmental (exposomic) and polygenic contributions to AL and their combined contribution to adolescent mental health. In this cohort study of N = 5,036 diverse youth (mean age 12 years) from the Adolescent Brain Cognitive Development Study, we calculated a latent AL score, childhood exposomic risk and genetic risk. We tested the associations of exposomic and polygenic risks with AL using linear mixed-effects models, and tested the mediating role of AL on the pathway from exposomic/polygenic risk to mental health. AL was significantly lower among non-Hispanic white youth compared to Hispanic and non-Hispanic black youth. Childhood exposomic burden was associated with AL in adolescence (β = 0.25, 95% CI 0.22–0.29, P < 0.001). In subset analysis of participants of European-like genetic ancestry (n = 2,928), the type 2 diabetes polygenic risk score (T2D-PRS; β = 0.11, 95% CI 0.07–0.14, P < 0.001) and major depressive disorder (MDD)-PRS (β = 0.05, 95% CI 0.02–0.09, P = 0.003) were associated with AL. Both PRSs showed significant gene–environment interactions such that, with greater polygenic risk, associations between exposome and AL were stronger. AL significantly mediated the indirect path from exposomic risk at age 11 years, and from both MDD-PRS and T2D-PRS to psychopathology at age 12 years. Our findings show that AL can be quantified in youth and is associated with exposomic and polygenic burden, supporting the diathesis–stress model. Using a large US cohort of adolescents, the authors examine exposomic and polygenic contributions to allostatic load and a mediating role of allostatic load on the path from exposomic and polygenic risks to psychopathology.
静态负荷（Allostatic load，AL）是指长期逆境对身体造成的累积性 "磨损"。我们测试了多环境（暴露基因组）和多基因对 AL 的影响，以及它们对青少年心理健康的综合影响。在这项队列研究中，我们对来自青少年大脑认知发展研究（Adolescent Brain Cognitive Development Study）的 N = 5,036 名不同青少年（平均年龄为 12 岁）进行了研究，计算出了潜在的 AL 评分、童年暴露风险和遗传风险。我们使用线性混合效应模型检验了暴露风险和多基因风险与AL的关联，并检验了AL在从暴露/多基因风险到心理健康这一路径上的中介作用。与西班牙裔和非西班牙裔黑人青少年相比，非西班牙裔白人青少年的AL明显较低。童年时期的暴露组学负担与青少年时期的AL相关（β = 0.25，95% CI 0.22-0.29，P < 0.001）。在对欧洲类基因血统参与者（n = 2928）进行的子集分析中，2 型糖尿病多基因风险评分（T2D-PRS；β = 0.11，95% CI 0.07-0.14，P < 0.001）和重度抑郁障碍（MDD）-PRS（β = 0.05，95% CI 0.02-0.09，P = 0.003）与 AL 相关。两个PRS都显示出明显的基因-环境交互作用，因此当多基因风险越大时，暴露组与AL之间的关联就越强。从 11 岁时的暴露组风险到 12 岁时的精神病理学，以及从 MDD-PRS 和 T2D-PRS 到精神病理学的间接路径，AL 起着重要的中介作用。我们的研究结果表明，AL 可以在青少年中量化，并且与暴露风险和多基因负担相关，支持 "病因-压力 "模型。作者利用一个大型美国青少年队列，研究了暴露基因组和多基因对异生质负荷的贡献，以及异生质负荷在暴露基因组和多基因风险通往精神病理学的道路上的中介作用。
{"title":"Exposomic and polygenic contributions to allostatic load in early adolescence","authors":"Kevin W. Hoffman, Kate T. Tran, Tyler M. Moore, Mārtiņš M. Gataviņš, Elina Visoki, Ohyoon Kwon, Grace E. DiDomenico, Barbara H. Chaiyachati, Laura M. Schultz, Laura Almasy, Matthew R. Hayes, Nikolaos P. Daskalakis, Ran Barzilay","doi":"10.1038/s44220-024-00255-9","DOIUrl":"10.1038/s44220-024-00255-9","url":null,"abstract":"Allostatic load (AL) is the cumulative ‘wear and tear’ on the body due to chronic adversity. We tested the poly-environmental (exposomic) and polygenic contributions to AL and their combined contribution to adolescent mental health. In this cohort study of N = 5,036 diverse youth (mean age 12 years) from the Adolescent Brain Cognitive Development Study, we calculated a latent AL score, childhood exposomic risk and genetic risk. We tested the associations of exposomic and polygenic risks with AL using linear mixed-effects models, and tested the mediating role of AL on the pathway from exposomic/polygenic risk to mental health. AL was significantly lower among non-Hispanic white youth compared to Hispanic and non-Hispanic black youth. Childhood exposomic burden was associated with AL in adolescence (β = 0.25, 95% CI 0.22–0.29, P < 0.001). In subset analysis of participants of European-like genetic ancestry (n = 2,928), the type 2 diabetes polygenic risk score (T2D-PRS; β = 0.11, 95% CI 0.07–0.14, P < 0.001) and major depressive disorder (MDD)-PRS (β = 0.05, 95% CI 0.02–0.09, P = 0.003) were associated with AL. Both PRSs showed significant gene–environment interactions such that, with greater polygenic risk, associations between exposome and AL were stronger. AL significantly mediated the indirect path from exposomic risk at age 11 years, and from both MDD-PRS and T2D-PRS to psychopathology at age 12 years. Our findings show that AL can be quantified in youth and is associated with exposomic and polygenic burden, supporting the diathesis–stress model. Using a large US cohort of adolescents, the authors examine exposomic and polygenic contributions to allostatic load and a mediating role of allostatic load on the path from exposomic and polygenic risks to psychopathology.","PeriodicalId":74247,"journal":{"name":"Nature mental health","volume":"2 7","pages":"828-839"},"PeriodicalIF":0.0,"publicationDate":"2024-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140980226","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-05-13DOI: 10.1038/s44220-024-00235-z
Yang Bai, Kevin Pacheco-Barrios, Niels Pacheco-Barrios, Guobiao Liang, Felipe Fregni
Aside from movement initiation and control, the primary motor cortex (M1) has been implicated in pain modulation mechanisms. A large body of clinical data has demonstrated that stimulation and behavioural activation of M1 result in clinically important pain relief in patients with specific chronic pain syndromes. However, despite its clinical importance, the full range of circuits for motor cortex-related analgesia (MCRA) remains an enigma. This Review draws on insights from experimental and clinical data and provides an overview of the neurobiological mechanisms of MCRA, with particular emphasis on its neurocircuitry basis. On the basis of structural and functional connections of the M1 within the pain connectome, neural circuits for MCRA are discussed at different levels of the neuroaxis, specifically, the endogenous pain modulation system, the thalamus, the extrapyramidal system, non-noxious somatosensory systems and cortico-limbic pain signatures. We believe that insights from this Review will expedite the understanding of M1-induced pain modulation and offer hope for successful mechanism-based refinements of this interventional approach in chronic pain management. In this Review, the authors discuss the neurobiological mechanisms of motor cortex-related analgesia, drawing insights from both experimental data and clinical data.
{"title":"Neurocircuitry basis of motor cortex-related analgesia as an emerging approach for chronic pain management","authors":"Yang Bai, Kevin Pacheco-Barrios, Niels Pacheco-Barrios, Guobiao Liang, Felipe Fregni","doi":"10.1038/s44220-024-00235-z","DOIUrl":"10.1038/s44220-024-00235-z","url":null,"abstract":"Aside from movement initiation and control, the primary motor cortex (M1) has been implicated in pain modulation mechanisms. A large body of clinical data has demonstrated that stimulation and behavioural activation of M1 result in clinically important pain relief in patients with specific chronic pain syndromes. However, despite its clinical importance, the full range of circuits for motor cortex-related analgesia (MCRA) remains an enigma. This Review draws on insights from experimental and clinical data and provides an overview of the neurobiological mechanisms of MCRA, with particular emphasis on its neurocircuitry basis. On the basis of structural and functional connections of the M1 within the pain connectome, neural circuits for MCRA are discussed at different levels of the neuroaxis, specifically, the endogenous pain modulation system, the thalamus, the extrapyramidal system, non-noxious somatosensory systems and cortico-limbic pain signatures. We believe that insights from this Review will expedite the understanding of M1-induced pain modulation and offer hope for successful mechanism-based refinements of this interventional approach in chronic pain management. In this Review, the authors discuss the neurobiological mechanisms of motor cortex-related analgesia, drawing insights from both experimental data and clinical data.","PeriodicalId":74247,"journal":{"name":"Nature mental health","volume":"2 5","pages":"496-513"},"PeriodicalIF":0.0,"publicationDate":"2024-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140919357","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-05-13DOI: 10.1038/s44220-024-00263-9
Eva S. A. Dijkstra, Summer B. Frandsen, Hanneke van Dijk, Felix Duecker, Joseph J. Taylor, Alexander T. Sack, Martijn Arns, Shan H. Siddiqi
{"title":"Author Correction: Probing prefrontal-sgACC connectivity using TMS-induced heart–brain coupling","authors":"Eva S. A. Dijkstra, Summer B. Frandsen, Hanneke van Dijk, Felix Duecker, Joseph J. Taylor, Alexander T. Sack, Martijn Arns, Shan H. Siddiqi","doi":"10.1038/s44220-024-00263-9","DOIUrl":"10.1038/s44220-024-00263-9","url":null,"abstract":"","PeriodicalId":74247,"journal":{"name":"Nature mental health","volume":"2 6","pages":"740-740"},"PeriodicalIF":0.0,"publicationDate":"2024-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.com/articles/s44220-024-00263-9.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141308932","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-05-13DOI: 10.1038/s44220-024-00262-w
ADHD is the most common neurodevelopmental disorder in children, yet despite a large increase in awareness and in the number of diagnoses, much less is known about how this disorder affects adults. More research is needed to understand how ADHD may present differently as a function of age or how the experience of ADHD may change in people as they age.
{"title":"ADHD grows up","authors":"","doi":"10.1038/s44220-024-00262-w","DOIUrl":"10.1038/s44220-024-00262-w","url":null,"abstract":"ADHD is the most common neurodevelopmental disorder in children, yet despite a large increase in awareness and in the number of diagnoses, much less is known about how this disorder affects adults. More research is needed to understand how ADHD may present differently as a function of age or how the experience of ADHD may change in people as they age.","PeriodicalId":74247,"journal":{"name":"Nature mental health","volume":"2 5","pages":"461-462"},"PeriodicalIF":0.0,"publicationDate":"2024-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.com/articles/s44220-024-00262-w.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140919366","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-05-13DOI: 10.1038/s44220-024-00251-z
Wenjie Hou, Barbara J. Sahakian, Christelle Langley, Yuqing Yang, R. A. I. Bethlehem, Qiang Luo
Emotion dysregulation is common in attention deficit hyperactivity disorder (ADHD), which is known to be clinically heterogeneous. However, it remains unclear whether emotion dysregulation represents a neuropsychological pathway to ADHD. Here, using a large population-based cohort (n = 6,053), we show that emotion dysregulation was associated with ADHD symptoms (partial eta2 = 0.21) and this persisted after controlling for the cognitive and motivational deficits. Emotion dysregulation mediated the association between smaller surface area of the right pars orbitalis and greater ADHD symptoms at 1-year follow-up, indicating an emotion pathway for ADHD. This pathway was associated with immune responses by both transcriptomic analyses and white blood cell markers. In an independent clinical sample for ADHD (n = 672), the emotion pathway improved the case/control classification accuracy. These findings suggest that emotion dysregulation is a core symptom and route to ADHD, which may not respond to the current pharmacological treatments for ADHD. Authors present data supporting a neuropsychological pathway between emotion dysregulation and ADHD symptoms involving morphometry of the right pars orbitalis, transcriptomic, and white blood cell markers.
{"title":"Emotion dysregulation and right pars orbitalis constitute a neuropsychological pathway to attention deficit hyperactivity disorder","authors":"Wenjie Hou, Barbara J. Sahakian, Christelle Langley, Yuqing Yang, R. A. I. Bethlehem, Qiang Luo","doi":"10.1038/s44220-024-00251-z","DOIUrl":"10.1038/s44220-024-00251-z","url":null,"abstract":"Emotion dysregulation is common in attention deficit hyperactivity disorder (ADHD), which is known to be clinically heterogeneous. However, it remains unclear whether emotion dysregulation represents a neuropsychological pathway to ADHD. Here, using a large population-based cohort (n = 6,053), we show that emotion dysregulation was associated with ADHD symptoms (partial eta2 = 0.21) and this persisted after controlling for the cognitive and motivational deficits. Emotion dysregulation mediated the association between smaller surface area of the right pars orbitalis and greater ADHD symptoms at 1-year follow-up, indicating an emotion pathway for ADHD. This pathway was associated with immune responses by both transcriptomic analyses and white blood cell markers. In an independent clinical sample for ADHD (n = 672), the emotion pathway improved the case/control classification accuracy. These findings suggest that emotion dysregulation is a core symptom and route to ADHD, which may not respond to the current pharmacological treatments for ADHD. Authors present data supporting a neuropsychological pathway between emotion dysregulation and ADHD symptoms involving morphometry of the right pars orbitalis, transcriptomic, and white blood cell markers.","PeriodicalId":74247,"journal":{"name":"Nature mental health","volume":"2 7","pages":"840-852"},"PeriodicalIF":0.0,"publicationDate":"2024-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140983035","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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