Osteoarthritis and cartilage open最新文献_第10页

White paper – A proposal towards objective biomechanical metrics as novel endpoints to document improvements in musculoskeletal function and mobility 白皮书-建议将客观生物力学指标作为记录肌肉骨骼功能和活动能力改善的新终点

Osteoarthritis and cartilage open

Pub Date : 2025-07-05 DOI: 10.1016/j.ocarto.2025.100648

Sónia A. Alves , Nicholas M. Brisson , Alison N. Agres , Mark Heyland , Ali Mobasheri , David J. Hunter , Tobias Winkler , Georg N. Duda

引用次数: 0

A fully-automated technique for cartilage morphometry in knees with severe radiographic osteoarthritis – Method development and validation 一种用于严重放射性骨关节炎膝关节软骨形态测量的全自动技术-方法开发和验证

Osteoarthritis and cartilage open

Pub Date : 2025-07-04 DOI: 10.1016/j.ocarto.2025.100645

Wolfgang Wirth , Felix Eckstein

Objective

Denuded areas of subchondral bone (dAB) pose a challenge for fully automated segmentation of articular cartilage and subchondral bone in knees with severe radiographic osteoarthritis using convolutional neural networks (CNNs). Here we propose an automated post-processing relying on a selection-based multi-atlas registration for reconstructing the total area of subchondral bone (tAB) to overcome this issue. We evaluate the agreement, accuracy and longitudinal sensitivity to cartilage change of this novel methodology.

Design

CNN-based models were trained using manual cartilage segmentations from sagittal DESS and coronal FLASH MRI of knees with radiographic (KLG2-4) or severe radiographic osteoarthritis (KLG4 only). These were then applied to KLG4 test knees with manual cartilage segmentations. Automated post-processing was applied to reconstruct missing parts of the tAB and to refine the segmentations, particularly for dABs. The agreement and accuracy of automated cartilage analysis were evaluated using Dice Similarity Coefficients (DSC) and Bland-Altman analyses; sensitivity to one-year change was assessed using the standardized response mean (SRM).

Results

Stronger agreement (DSC 0.80 ± 0.07 to 0.89 ± 0.05) and lower systematic offsets for cartilage thickness (1.2 %–8.4 %) and tAB area (−0.4 %–4.3 %) were observed for CNNs trained on KLG2-4 rather than KLG4 knees; overall, results were superior to those without registration-based post-processing. Sensitivity to change was greatest for manual segmentation of DESS (SRM ≥ −0.69; automated: ≥−0.56) and for automated segmentation of FLASH (≥−0.74; manual ≥−0.44).

Conclusion

CNN-based segmentation combined with registration-based post-processing for accurate delineation of tABs/dABs substantially improves fully-automated (longitudinal) analysis of cartilage and subchondral bone morphology in knees with severe radiographic osteoarthritis.

目的利用卷积神经网络（cnn）对严重影像学骨关节炎患者膝关节关节软骨和软骨下骨的全自动分割提出了挑战。为了克服这一问题，我们提出了一种基于选择的多图谱配准的自动后处理方法来重建软骨下骨（tAB）的总面积。我们评估的一致性，准确性和纵向敏感性的软骨变化的这种新方法。基于cnn的模型通过人工软骨分割进行训练，这些软骨分割来自膝关节矢状面DESS和冠状面FLASH MRI，并伴有x线摄影（KLG2-4）或严重的x线摄影骨关节炎（仅KLG4）。然后将这些应用于手动软骨分割的KLG4测试膝关节。自动后处理应用于重建标签缺失的部分，并细化分割，特别是对于数据库。采用Dice相似系数（DSC）和Bland-Altman分析评估自动软骨分析的一致性和准确性；采用标准化反应均值（SRM）评估对一年变化的敏感性。结果与KLG4相比，在KLG2-4上训练的cnn具有更强的一致性（DSC为0.80±0.07 ~ 0.89±0.05），软骨厚度（1.2% ~ 8.4%）和tAB面积（- 0.4% ~ 4.3%）的系统偏移量更小；总的来说，结果优于那些没有基于注册的后处理。人工分割DESS对变化的敏感性最高(SRM≥- 0.69；automated:≥−0.56)和自动分割FLASH(≥−0.74；手动≥−0.44)。结论基于cnn的分割结合基于配准的后处理可准确描绘tABs/dABs，大大改善了严重影像学骨关节炎膝关节软骨和软骨下骨形态的全自动（纵向）分析。

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引用次数: 0

Good long-term functional outcomes after rotationplasty despite osteoarthritis in the (pseudo)knee 尽管（假）膝骨关节炎，旋转成形术后良好的长期功能预后

Osteoarthritis and cartilage open

Pub Date : 2025-06-26 DOI: 10.1016/j.ocarto.2025.100644

G.G.J. Krebbekx , F.F. Smithuis , M.J.C. Duivenvoorden , R. Hemke , I.N. Sierevelt , G.R. Schaap , J.A.M. Bramer , G.M.M.J. Kerkhoffs , F.G.M. Verspoor

Objective

Rotationplasty is a surgical procedure primarily performed in patients with malignancies around the knee. Altered gait mechanics after surgery, such as reduced flexion of the (pseudo)knee and ipsilateral hip and changes in ground reaction forces, may predispose patients to osteoarthritis (OA) in the lower extremities. This study evaluated the long-term prevalence of OA and its association with pain and daily functioning.

Method

Rotationplasty survivors who underwent surgery between 1980 and 2002 in Amsterdam received radiographic assessment of the (pseudo)knee, contralateral ankle, and both hips (weight-bearing mortise, lateral and AP views). OA was graded using the Kellgren-Lawrence scale. Functional outcomes, pain, quality of life, and sports participation were evaluated with the FAOS, AOFAS, and Harris Hip Score questionnaires. Statistical analyses included t-tests, Mann-Whitney U, chi-square, and Fisher's exact tests.

Results

Thirty patients (mean age 49.4 ± 9.2 years; mean follow-up 32.4 ± 4.6 years) participated. Moderate-to-severe OA was found in 43 % of ipsilateral (pseudo)knees, 10 % of contralateral ankles, 33 % of ipsilateral hips, and 11 % of contralateral hips. Osteophytes were most common in the anterior tibial and subtalar regions (20 %), and joint space narrowing was most frequent in the subtalar (20 %) and medial tibiotalar (13 %) regions. Functional scores were generally favorable. The presence of osteoarthritis in the pseudo-knee was significantly associated with longer follow-up time.

Conclusion

Functional outcomes after rotationplasty are well preserved over time, despite a higher prevalence of osteoarthritis in the (pseudo)knee compared to the contralateral ankle as a long-term consequence of the procedure.

目的旋转成形术是一种主要用于膝关节周围恶性肿瘤患者的外科手术。手术后步态力学的改变，如假膝和同侧髋关节屈曲减少以及地面反作用力的改变，可能使患者易患下肢骨关节炎。本研究评估了OA的长期患病率及其与疼痛和日常功能的关系。方法1980年至2002年间在阿姆斯特丹接受手术的旋转成形术幸存者接受假膝关节、对侧踝关节和双髋的x线片评估（负重、侧位和正位）。使用kelgren - lawrence量表对OA进行评分。通过FAOS、AOFAS和Harris髋关节评分问卷对功能结局、疼痛、生活质量和运动参与进行评估。统计分析包括t检验、Mann-Whitney U检验、卡方检验和Fisher精确检验。结果30例患者平均年龄49.4±9.2岁；平均随访32.4±4.6年)。43%的同侧（假）膝关节、10%的对侧踝关节、33%的同侧髋关节和11%的对侧髋关节存在中度至重度骨关节炎。骨赘最常见于胫骨前区和距下区（20%），关节间隙狭窄最常见于距下区（20%）和胫骨内侧区（13%）。功能评分总体较好。假膝骨关节炎的存在与较长的随访时间显著相关。结论：旋转成形术后的功能结果随着时间的推移得到了很好的保存，尽管与对侧踝关节相比，假膝的骨关节炎患病率更高，这是手术的长期后果。

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引用次数: 0

In knee osteoarthritis, the production of cytokines and metalloproteinases in presence of chondrocytes and CD4+ T cells depends on T cell subset: An in vitro analysis 在膝关节骨关节炎中，存在软骨细胞和CD4+ T细胞的细胞因子和金属蛋白酶的产生取决于T细胞亚群：一项体外分析

Osteoarthritis and cartilage open

Pub Date : 2025-06-18 DOI: 10.1016/j.ocarto.2025.100642

H. Platzer , M. Wellbrock , G. Pourbozorg , R. Mayakrishnan , S. Gantz , B. Khamees , S. Maciej , B. Moradi

Objective

Osteoarthritis (OA) is driven by biomechanical and biochemical inflammatory processes, including CD4⁺ T cell infiltration and activation. However, the role of CD4⁺ T cell subsets interacting with neighboring cells shaping the local inflammatory milieu have remained largely unexplored. This study aimed to investigate in vitro whether interaction of chondrocyte and CD4⁺ T cells modulate cytokine and metalloproteinase production in OA, and to determine if this modulation differ depending on CD4⁺ T cell subsets.

Method

Nineteen patients with knee OA undergoing knee replacement were enrolled. From peripheral blood CD4⁺ T cells were isolated and differentiated into subsets (Th1, Th2, Th17, Treg) using a novel developed protocol. T cell differentiation was validated by flow cytometry. Chondrocytes were mono- and co-cultured with T cell subsets and in culture supernatant cytokine and metalloproteinase levels were quantified using ELISA and multiplex assays.

Results

Compared to monocultures levels MMP-1/3/9/13 and IL-6 were elevated in all co-cultures of chondrocytes and CD4⁺ T cell subsets, with the highest levels in Th17 co-cultures. GM-CSF, IL-9, IL-17 were specifically elevated in Th17 co-cultures and IFN-γ in Th1 co-cultures. TNF-α production was significantly reduced only in Treg co-culture compared to monoculture approach.

Conclusion

This study indicates that chondrocytes can interact with CD4⁺ T cell subsets in OA, modulating the production of metalloproteinases and cytokines to varying degrees, depending on the CD4⁺ T cell subset. Our findings can open new avenues in OA treatment using T cell-based or T cell subset-targeted therapies to modulate inflammatory patterns in affected OA joints.

目的骨关节炎（OA）是由生物力学和生化炎症过程驱动的，包括CD4+ T细胞的浸润和活化。然而，CD4+ T细胞亚群与邻近细胞相互作用形成局部炎症环境的作用在很大程度上仍未被探索。本研究旨在体外研究软骨细胞和CD4+ T细胞的相互作用是否调节OA中细胞因子和金属蛋白酶的产生，并确定这种调节是否取决于CD4+ T细胞亚群。方法19例膝关节OA患者行膝关节置换术。从外周血中分离CD4+ T细胞并使用新开发的方案将其分化为亚群（Th1, Th2, Th17, Treg）。流式细胞术证实T细胞分化。软骨细胞与T细胞亚群单独或共培养，用ELISA和多重检测法定量培养上清细胞因子和金属蛋白酶水平。结果与单培养相比，MMP-1/3/9/13和IL-6在所有软骨细胞和CD4+ T细胞亚群共培养中均升高，其中Th17共培养水平最高。Th17共培养中GM-CSF、IL-9、IL-17特异性升高，Th1共培养中IFN-γ特异性升高。与单一培养相比，只有Treg共培养显著降低了TNF-α的产生。结论软骨细胞在骨性关节炎中可与CD4+ T细胞亚群相互作用，不同程度地调节金属蛋白酶和细胞因子的产生，这取决于CD4+ T细胞亚群。我们的研究结果可以为使用基于T细胞或T细胞亚群靶向治疗来调节受影响OA关节的炎症模式开辟新的途径。

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引用次数: 0

Intra-articular injections for knee osteoarthritis management: Analysis of cost-effectiveness 膝关节骨性关节炎治疗的关节内注射：成本-效果分析

Osteoarthritis and cartilage open

Pub Date : 2025-06-10 DOI: 10.1016/j.ocarto.2025.100641

Hanna Mass , Jamie E. Collins , Catherine Yang , David J. Hunter , Morgan H. Jones , Love Tsai , Stephen P. Messier , Tuhina Neogi , Jeffrey N. Katz , Elena Losina

Objective

Intra-articular injections (IAI) are commonly used to treat knee pain in persons with knee osteoarthritis (OA). We sought to determine the value of commonly used IAIs in knee OA management.

Methods

We used the validated Osteoarthritis Policy Model (OAPol) to assess the value of saline, corticosteroid (CS), hyaluronic acid (HA), and platelet-rich plasma (PRP) IAIs in knee OA management. We conducted a meta-analysis of high quality studies to estimate IAI-specific pain reduction. We assumed that repeat CS injections increase the risk of OA progression threefold in the base case. We determined the value of specific IAIs with incremental cost-effectiveness ratios (ICERs). We conducted sensitivity analyses to account for uncertainty in input parameters.

Results

In the base case, ICERs were $8300/QALY for saline compared to no injection, $54,500/QALY for HA compared to saline, and $112,100/QALY for PRP compared to HA. CS was dominated (more costly, less effective) by saline. If saline was not included, ICER for HA was reduced to $22,400/QALY. In sensitivity analyses that assumed CS does not increase OA progression, ICERs were $6000/QALY for CS compared to no injection, HA dominated compared to CS. ICER for PRP was estimated at $151,300/QALY. ICERs for PRP were higher than currently accepted willingness to pay thresholds. PRP ICER ranges were most sensitive to discontinuation probability and cost.

Conclusions

CS could offer good value for knee OA management if the impact on OA progression is small. Value of PRP depends greatly on its price, with current prices leading to value exceeding well-accepted cost-effectiveness thresholds. Better data on the impact of CS on OA progression and pain efficacy related to PRP would offer critical insights for policymakers into the value of specific IAIs in the management of knee OA.

目的关节内注射（IAI）是治疗膝关节骨性关节炎（OA）患者膝关节疼痛的常用方法。我们试图确定常用人工智能在膝关节OA治疗中的价值。方法采用经验证的骨关节炎政策模型（OAPol）评估生理盐水、皮质类固醇（CS）、透明质酸（HA）和富血小板血浆（PRP） iai在膝关节OA治疗中的价值。我们进行了一项高质量研究的荟萃分析，以估计iai特异性疼痛减轻。我们假设在基本情况下，重复CS注射会使OA进展的风险增加三倍。我们用增量成本-效果比（ICERs）来确定特定iai的价值。我们进行了敏感性分析，以解释输入参数的不确定性。结果在基本情况下，与不注射相比，生理盐水组ICERs为8300美元/QALY，与生理盐水组相比，HA组ICERs为54,500美元/QALY，与HA组相比，PRP组ICERs为112,100美元/QALY。CS以生理盐水为主（成本较高，效果较差）。如果不包括生理盐水，HA的ICER降低到22400美元/QALY。在假设CS不会增加OA进展的敏感性分析中，与未注射相比，CS的ICERs为6000美元/QALY，与CS相比，HA占主导地位。PRP的费用估计为$151,300/QALY。PRP的ICERs高于目前接受的支付意愿阈值。PRP - ICER范围对停药概率和停药成本最为敏感。结论在对骨性关节炎进展影响较小的情况下，scs在膝关节骨性关节炎治疗中具有较好的应用价值。PRP的价值在很大程度上取决于其价格，目前的价格导致其价值超过广为接受的成本效益阈值。更好的CS对关节炎进展和与PRP相关的疼痛疗效影响的数据将为决策者提供关键的见解，以了解特定iai在膝关节OA管理中的价值。

{"title":"Intra-articular injections for knee osteoarthritis management: Analysis of cost-effectiveness","authors":"Hanna Mass , Jamie E. Collins , Catherine Yang , David J. Hunter , Morgan H. Jones , Love Tsai , Stephen P. Messier , Tuhina Neogi , Jeffrey N. Katz , Elena Losina","doi":"10.1016/j.ocarto.2025.100641","DOIUrl":"10.1016/j.ocarto.2025.100641","url":null,"abstract":"<div><h3>Objective</h3><div>Intra-articular injections (IAI) are commonly used to treat knee pain in persons with knee osteoarthritis (OA). We sought to determine the value of commonly used IAIs in knee OA management.</div></div><div><h3>Methods</h3><div>We used the validated Osteoarthritis Policy Model (OAPol) to assess the value of saline, corticosteroid (CS), hyaluronic acid (HA), and platelet-rich plasma (PRP) IAIs in knee OA management. We conducted a meta-analysis of high quality studies to estimate IAI-specific pain reduction. We assumed that repeat CS injections increase the risk of OA progression threefold in the base case. We determined the value of specific IAIs with incremental cost-effectiveness ratios (ICERs). We conducted sensitivity analyses to account for uncertainty in input parameters.</div></div><div><h3>Results</h3><div>In the base case, ICERs were $8300/QALY for saline compared to no injection, $54,500/QALY for HA compared to saline, and $112,100/QALY for PRP compared to HA. CS was dominated (more costly, less effective) by saline. <strong>If saline was not included, ICER for HA was reduced to $22,400/QALY.</strong> In sensitivity analyses that assumed CS does not increase OA progression, ICERs were $6000/QALY for CS compared to no injection, HA dominated compared to CS. ICER for PRP was estimated at $151,300/QALY. ICERs for PRP were higher than currently accepted willingness to pay thresholds. PRP ICER ranges were most sensitive to discontinuation probability and cost.</div></div><div><h3>Conclusions</h3><div>CS could offer good value for knee OA management if the impact on OA progression is small. <strong>Value of PRP depends greatly on its price, with current prices leading to value exceeding well</strong><strong>-</strong><strong>accepted cost-effectiveness thresholds</strong>. Better data on the impact of CS on OA progression and pain efficacy related to PRP would offer critical insights for policymakers into the value of specific IAIs in the management of knee OA.</div></div>","PeriodicalId":74377,"journal":{"name":"Osteoarthritis and cartilage open","volume":"7 3","pages":"Article 100641"},"PeriodicalIF":0.0,"publicationDate":"2025-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144654817","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The frequency and severity of ultrasound-detected osteoarthritis features in the knees and their associations with pain: Cross-sectional analyses of the Nor-Hand study 超声检测膝关节骨关节炎特征的频率和严重程度及其与疼痛的关系：Nor-Hand研究的横断面分析

Osteoarthritis and cartilage open

Pub Date : 2025-06-05 DOI: 10.1016/j.ocarto.2025.100640

Caroline H. Dekkerhus , Alexander Mathiessen , Caroline M. Fjellstad , Barbara Slatwkosky-Christensen , Hilde Berner Hammer , Ida K. Haugen

Objective

To investigate the frequency and severity of ultrasound-detected osteophytes and synovitis in people with and without knee osteoarthritis (OA), and to explore the association between these ultrasound features and pain.

Design

In the Nor-Hand study, both knees were assessed for osteophytes (0–3 scale, four locations per knee) and grey-scale synovitis (0–3 scale). The frequency and severity of the ultrasound-detected features were compared in individuals with and without knee OA defined by the American College of Rheumatology criteria. Pain was self-reported in each knee (yes/no) and by the Western/Ontario McMaster University index (WOMAC). The associations between ultrasound-detected features and pain were examined by regression analyses adjusted for age, sex, and body mass index.

Results

We analyzed 286 participants. Osteophytes of all sizes were more common in participants with knee OA compared to those without (65.9 % vs. 40.8 %, p < 0.001). No between-group difference was found for the frequency of any grey-scale synovitis (45.5 % vs. 44.7 %, p = 0.67), while severe synovitis was more common in those with knee OA. Ultrasound-detected osteophyte sum score, but not synovitis, was associated with WOMAC pain (B = 0.18, 95 % CI 0.03–0.32). Osteophytes of all sizes were associated with pain in the same knee with odds ratio (OR, 95 % CI) ranging from 1.85 (1.20–2.84) to 9.02 (4.04–20.10). Statistically significant association was found for severe synovitis only (OR = 6.63, 95 % CI 2.26–19.43).

Conclusions

Ultrasound-detected osteophytes were prevalent in people with knee OA and were associated with pain. OA pathology in individuals without fulfilling the knee OA criteria may reflect early or subclinical OA.

目的探讨膝关节骨性关节炎（OA）患者超声检查骨赘和滑膜炎的频率和严重程度，并探讨这些超声特征与疼痛的关系。在Nor-Hand研究中，评估双膝骨疣（0-3级，每个膝关节四个位置）和灰色滑膜炎（0-3级）。根据美国风湿病学会的标准，比较了有和没有膝关节OA的个体的超声检测特征的频率和严重程度。每个膝盖都自我报告疼痛（是/否），并通过西部/安大略省麦克马斯特大学指数（WOMAC）。通过年龄、性别和体重指数调整后的回归分析，检查超声检测特征与疼痛之间的关系。结果我们分析了286名参与者。各种大小的骨赘在患有膝关节OA的参与者中比没有膝关节OA的参与者更常见(65.9%比40.8%,p <；0.001)。灰色滑膜炎的发生率组间无差异（45.5%对44.7%,p = 0.67），而严重滑膜炎在膝关节OA患者中更为常见。超声检测骨赘总和评分与WOMAC疼痛相关，但与滑膜炎无关（B = 0.18, 95% CI 0.03-0.32）。不同大小的骨赘均与同一膝关节疼痛相关，优势比（OR, 95% CI）从1.85（1.20-2.84）到9.02（4.04-20.10）不等。仅在严重滑膜炎中发现有统计学意义的关联（OR = 6.63, 95% CI 2.26-19.43）。结论超声检出的骨赘在膝关节OA患者中普遍存在，且与疼痛有关。不符合膝关节OA标准的个体的OA病理可能反映早期或亚临床OA。

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引用次数: 0

Association between weather features and symptoms in hand osteoarthritis: Results from the DIGICOD cohort 天气特征与手骨关节炎症状之间的关系：来自DIGICOD队列的结果

Osteoarthritis and cartilage open

Pub Date : 2025-06-05 DOI: 10.1016/j.ocarto.2025.100639

Mathilde Pezot , Romane Lacoste-Badie , Sophie Tuffet , Alexandra Rousseau , Pascal Richette , Bruno Fautrel , Francis Berenbaum , Alice Courties , Jérémie Sellam

Objective

This cross-sectional study aimed to investigate the association between weather and joint symptoms in patients with hand osteoarthritis (HOA).

Design

We used baseline data from the DIGICOD cohort, a monocentric cohort of patients with HOA, and meteorological measurements (temperature, humidity, barometric pressure) in the Paris region during the 72 h before inclusion in the cohort. Clinical outcomes were AUSCAN subscores (pain, stiffness, function), spontaneous and pressure tender joint count (TJC), visual analog scale (VAS) score for hand pain during activity and at rest, and the Functional Index for Hand Osteoarthritis score. We used logistic regression models to search for associations between meteorological measurements and clinical outcomes, adjusting for sex, age, Kellgren-Lawrence score and Hospital Anxiety and Depression Scale score.

Results

We analyzed data for 377 patients (mean age 66.5 ± 7.4 years, 85 % female). The AUSCAN-pain subscale score was not significantly associated with temperature, humidity or barometric pressure. Only spontaneous TJC was associated with relative humidity, and TJC at pressure was negatively associated with barometric pressure, both without dose-effect. Pain scores were not associated with temperature, and function and stiffness scores were not associated with any meteorological variable.

Conclusions

This is the first study to investigate in a large cohort the association between meteorological factors and HOA symptoms. Despite a few isolated associations, our results do not clearly support the worsening of hand joint symptom during humid or rainy weather.

目的本研究旨在探讨天气与手骨关节炎（HOA）患者关节症状的关系。我们使用DIGICOD队列（HOA患者的单中心队列）的基线数据和巴黎地区在纳入队列前72小时的气象测量数据（温度、湿度、气压）。临床结果为AUSCAN亚评分（疼痛、僵硬、功能）、自发性和压痛关节计数（TJC）、活动和休息时手部疼痛的视觉模拟评分（VAS）评分以及手骨关节炎的功能指数评分。我们使用逻辑回归模型来搜索气象测量与临床结果之间的关联，调整性别、年龄、kelgren - lawrence评分和医院焦虑和抑郁量表评分。结果我们分析了377例患者的资料（平均年龄66.5±7.4岁，85%为女性）。auscan -疼痛亚量表评分与温度、湿度或气压无显著相关性。只有自发TJC与相对湿度相关，压力下TJC与气压负相关，均无剂量效应。疼痛评分与温度无关，功能和僵硬评分与任何气象变量无关。结论本研究首次在大队列中调查气象因素与HOA症状之间的关系。尽管有一些孤立的关联，我们的研究结果并不能明确地支持在潮湿或下雨的天气中手部关节症状的恶化。

{"title":"Association between weather features and symptoms in hand osteoarthritis: Results from the DIGICOD cohort","authors":"Mathilde Pezot , Romane Lacoste-Badie , Sophie Tuffet , Alexandra Rousseau , Pascal Richette , Bruno Fautrel , Francis Berenbaum , Alice Courties , Jérémie Sellam","doi":"10.1016/j.ocarto.2025.100639","DOIUrl":"10.1016/j.ocarto.2025.100639","url":null,"abstract":"<div><h3>Objective</h3><div>This cross-sectional study aimed to investigate the association between weather and joint symptoms in patients with hand osteoarthritis (HOA).</div></div><div><h3>Design</h3><div>We used baseline data from the DIGICOD cohort, a monocentric cohort of patients with HOA, and meteorological measurements (temperature, humidity, barometric pressure) in the Paris region during the 72 h before inclusion in the cohort. Clinical outcomes were AUSCAN subscores (pain, stiffness, function), spontaneous and pressure tender joint count (TJC), visual analog scale (VAS) score for hand pain during activity and at rest, and the Functional Index for Hand Osteoarthritis score. We used logistic regression models to search for associations between meteorological measurements and clinical outcomes, adjusting for sex, age, Kellgren-Lawrence score and Hospital Anxiety and Depression Scale score.</div></div><div><h3>Results</h3><div>We analyzed data for 377 patients (mean age 66.5 ± 7.4 years, 85 % female). The AUSCAN-pain subscale score was not significantly associated with temperature, humidity or barometric pressure. Only spontaneous TJC was associated with relative humidity, and TJC at pressure was negatively associated with barometric pressure, both without dose-effect. Pain scores were not associated with temperature, and function and stiffness scores were not associated with any meteorological variable.</div></div><div><h3>Conclusions</h3><div>This is the first study to investigate in a large cohort the association between meteorological factors and HOA symptoms. Despite a few isolated associations, our results do not clearly support the worsening of hand joint symptom during humid or rainy weather.</div></div>","PeriodicalId":74377,"journal":{"name":"Osteoarthritis and cartilage open","volume":"7 3","pages":"Article 100639"},"PeriodicalIF":0.0,"publicationDate":"2025-06-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144470098","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Analysis of multiple MRI-based quantitative structural measurements of knee osteoarthritis in a case control study – association with pain and structural progression and comparison to semi-quantitative scoring 在一项病例对照研究中对膝关节骨关节炎的多重mri定量结构测量进行分析——与疼痛和结构进展的关联以及与半定量评分的比较

Osteoarthritis and cartilage open

Pub Date : 2025-06-05 DOI: 10.1016/j.ocarto.2025.100638

Stacy E. Smith , Lawrence Lo , Meera Sury , Sara M. Bahouth , Ming Yin , Lena F. Schaefer , Jamie E. Collins , Jeffrey Duryea

Objective

To use software-based magnetic resonance imaging (MRI) measures of multiple features of knee osteoarthritis (KOA) to predict radiographic and pain progression in persons with KOA, and compare to a study that used primarily semi-quantitative (SQ) scoring.

Design

Data from the Foundation for the National Institutes of Health Osteoarthritis Biomarkers Consortium (FNIH) nested case-control study (600 subjects divided into case and control groups based on knee pain and/or radiographic progression) were used. The MRI Osteoarthritis Software Scoring (MOSS) was used to quantitatively assess medial femoral cartilage, bone marrow lesions, osteophyte volume, effusion-synovitis volume, and a measure of Hoffa's synovitis at baseline and 24-months using readers with diverse levels of expertise. Association between baseline and baseline to 24-month change with progressor status was examined and discriminative ability assessed using the c-statistic (AUC) computed under 10-fold cross validation.

Results

AUC values ranged from 0.690 to 0.726 to predict combined pain/radiographic progression and from 0.709 to 0.804 to predict radiographic progression alone. Bone marrow lesions and osteophyte volume played a role in all analyses. Medial femoral cartilage was significant for all but the cross-sectional analysis involving pain progression. Comparison to results from a separate publication showed that MOSS offered similar discrimination to a published model that primarily used SQ scoring.

Conclusions

We found a high level of discrimination particularly for radiographic progression analysis. Use of fast automated software and readers with varied prior experience make MOSS a useful tool for enriching future clinical trials and for other large studies of KOA.

目的利用基于软件的磁共振成像（MRI）测量膝关节骨关节炎（KOA）的多种特征来预测KOA患者的放射学和疼痛进展，并与主要使用半定量（SQ）评分的研究进行比较。设计数据来自美国国立卫生研究院骨关节炎生物标志物联盟基金会（FNIH）巢式病例对照研究（600名受试者根据膝关节疼痛和/或放射学进展分为病例组和对照组）。MRI骨关节炎软件评分（MOSS）用于定量评估股骨内侧软骨、骨髓病变、骨赘体积、积液-滑膜炎体积，并使用具有不同专业水平的读者在基线和24个月时测量Hoffa滑膜炎。检查基线和基线至24个月变化与进展状态之间的关系，并使用10倍交叉验证计算的c统计量（AUC）评估判别能力。结果预测疼痛/影像学进展的auc值在0.690 ~ 0.726之间，单独预测影像学进展的auc值在0.709 ~ 0.804之间。骨髓病变和骨赘体积在所有分析中都起作用。除了涉及疼痛进展的横截面分析外，股骨内侧软骨在所有情况下都很重要。与独立出版物的结果比较表明，MOSS与主要使用SQ评分的已发表模型提供了类似的歧视。结论：我们发现了高度的歧视，特别是在放射学进展分析中。使用快速自动化软件和具有不同先前经验的读者使MOSS成为丰富未来临床试验和其他大型KOA研究的有用工具。

{"title":"Analysis of multiple MRI-based quantitative structural measurements of knee osteoarthritis in a case control study – association with pain and structural progression and comparison to semi-quantitative scoring","authors":"Stacy E. Smith , Lawrence Lo , Meera Sury , Sara M. Bahouth , Ming Yin , Lena F. Schaefer , Jamie E. Collins , Jeffrey Duryea","doi":"10.1016/j.ocarto.2025.100638","DOIUrl":"10.1016/j.ocarto.2025.100638","url":null,"abstract":"<div><h3>Objective</h3><div>To use software-based magnetic resonance imaging (MRI) measures of multiple features of knee osteoarthritis (KOA) to predict radiographic and pain progression in persons with KOA, and compare to a study that used primarily semi-quantitative (SQ) scoring.</div></div><div><h3>Design</h3><div>Data from the Foundation for the National Institutes of Health Osteoarthritis Biomarkers Consortium (FNIH) nested case-control study (600 subjects divided into case and control groups based on knee pain and/or radiographic progression) were used. The MRI Osteoarthritis Software Scoring (MOSS) was used to quantitatively assess medial femoral cartilage, bone marrow lesions, osteophyte volume, effusion-synovitis volume, and a measure of Hoffa's synovitis at baseline and 24-months using readers with diverse levels of expertise. Association between baseline and baseline to 24-month change with progressor status was examined and discriminative ability assessed using the c-statistic (AUC) computed under 10-fold cross validation.</div></div><div><h3>Results</h3><div>AUC values ranged from 0.690 to 0.726 to predict combined pain/radiographic progression and from 0.709 to 0.804 to predict radiographic progression alone. Bone marrow lesions and osteophyte volume played a role in all analyses. Medial femoral cartilage was significant for all but the cross-sectional analysis involving pain progression. Comparison to results from a separate publication showed that MOSS offered similar discrimination to a published model that primarily used SQ scoring.</div></div><div><h3>Conclusions</h3><div>We found a high level of discrimination particularly for radiographic progression analysis. Use of fast automated software and readers with varied prior experience make MOSS a useful tool for enriching future clinical trials and for other large studies of KOA.</div></div>","PeriodicalId":74377,"journal":{"name":"Osteoarthritis and cartilage open","volume":"7 3","pages":"Article 100638"},"PeriodicalIF":0.0,"publicationDate":"2025-06-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144262531","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Familial risks of five types of osteoarthritis in first-, second- and third-degree relatives - A nationwide Swedish family study 一、二、三度亲属中五种骨性关节炎的家族风险——一项瑞典全国家庭研究

Osteoarthritis and cartilage open

Pub Date : 2025-05-30 DOI: 10.1016/j.ocarto.2025.100637

Christian Anker-Hansen, MirNabi Pirouzifard, Jan Sundquist, Kristina Sundquist, Bengt Zöller

Objective

Osteoarthritis (OA) is a common degenerative disease with a genetic contribution. However, no large nationwide family study concerning the heredity of OA has been published. This first nationwide study aimed to determine the familial risks of the main types of OA in twins, full-siblings, half-siblings, and cousins in Sweden.

Design

The Swedish Multigeneration register was linked to the National Patient Register (NPR) to investigate the heredity of OA (poly-, hip-, knee-, first carpometacarpal joint-, and other-OA) between 1997 and 2018. Offspring born by Swedish parents were included. The adjusted familial hazard ratios (HRs) with 95 % confidence interval (CI) were determined for OA among twins, full-siblings, half-siblings, and cousins. Adjustments were made for birth year, sex, educational level, and comorbidities (chronic obstructive pulmonary disease, alcoholism, and obesity).

Results

A total of 6 547 966 individuals (48.77 % women) were included with mean age 41.44 years (range 0–86.96 years) at end of follow-up. Familial HRs were increased for all five types of OA (even in cousins) and correlated to degree of genetic resemblance between relatives. For instance, adjusted HRs among full-siblings were for poly-OA 2.29 (95 % CI 2.09–2.51), hip-OA 2.04 (95 % CI 1.98–2.07), knee-OA 1.75 (95 % CI 1.73–1.77), thumb-OA 2.60 (95 % CI 2.45–2.76), and other-OA 1.52 (95 % CI 1.48–1.56).

Conclusions

Heredity is an important predictor of future risk of OA for all five types of OA in the Swedish population. Strongest heredity was observed for first carpometacarpal joint -OA followed by poly-OA and hip-OA. Weakest heredity was observed for knee-OA and other-OA.

目的骨关节炎（OA）是一种常见的与遗传有关的退行性疾病。然而，关于OA遗传的大型全国性家庭研究尚未发表。这是第一个全国性的研究，旨在确定瑞典双胞胎、全兄妹、同父异母兄妹和堂兄妹中主要类型OA的家族风险。瑞典多代登记与国家患者登记（NPR）相关联，以调查1997年至2018年间OA（多骨、髋关节、膝关节、第一腕关节和其他骨关节炎）的遗传。瑞典父母所生的后代也包括在内。测定OA在双胞胎、全兄妹、同父异母兄妹和表亲中的校正家族风险比（HRs），置信区间为95%。根据出生年份、性别、教育水平和合并症（慢性阻塞性肺病、酒精中毒和肥胖）进行了调整。结果共纳入6 547 966例（女性48.77%），随访结束时平均年龄41.44岁（0 ~ 86.96岁）。家族hr在所有五种类型的OA中都增加了（即使在表亲中），并且与亲属之间的遗传相似性程度相关。例如，全同胞兄弟姐妹的调整hr为：多发性oa 2.29 (95% CI 2.09-2.51)，髋部oa 2.04 (95% CI 1.98-2.07)，膝关节oa 1.75 (95% CI 1.73-1.77)，手指oa 2.60 (95% CI 2.45-2.76)，其他oa 1.52 （95% CI 1.48-1.56）。结论在瑞典人群中，对所有五种类型的OA来说，健康度是未来OA风险的重要预测因素。首先是腕掌关节骨性关节炎，其次是多发性骨性关节炎和髋关节骨性关节炎。膝关节骨性关节炎和其他骨性关节炎的遗传最弱。

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引用次数: 0

Bidirectional causal relationship between obesity and osteoarthritis: Insights from a two-sample Mendelian randomization study 肥胖和骨关节炎之间的双向因果关系：来自两样本孟德尔随机化研究的见解

Osteoarthritis and cartilage open

Pub Date : 2025-05-27 DOI: 10.1016/j.ocarto.2025.100636

Anne Kamps , Jos Runhaar , Katerina Trajanoska , William D. Thompson , Weiya Zhang , Bahar Sedaghati-khayat , Joyce B.J. van Meurs , Sita M.A. Bierma-Zeinstra

Objective

Osteoarthritis (OA) is a prevalent chronic disease associated with disability worldwide, and obesity is a key modifiable risk factor for OA. The study's aim was to investigate the causal relationship between obesity and OA.

Method

This study employed a two-sample Mendelian randomization (MR) approach to investigate the bidirectional causal relationship between obesity, using body mass index (BMI) as its proxy, and OA of the knee, hip, and hand. Genetic instruments were derived from large-scale GWAS meta-analyses, including ∼681,000 individuals for BMI and ∼827,000 individuals (177,000 OA cases) for OA. Inverse variance weighted with multiplicative random effects analysis was performed as primary analysis, and in addition sensitivity analyses relying on different assumptions were performed.

Results

The MR analysis revealed that genetically predicted BMI had a causal effect on increased risk of knee (OR 1.91, 95 % CI 1.80–2.03), hip (OR 1.52, 95 % CI 1.41–1.64) and hand OA (OR 1.21, 95 % CI 1.04–1.23). Sensitivity analyses confirmed the robustness of these associations. However, there was no evidence for a causal effect from knee, hip or hand OA on BMI.

Conclusion

This study provides strong evidence supporting a causal effect of obesity (measured by BMI) on OA, with a more pronounced effect in weight-bearing knee & hip joints compared to non-weight-bearing hand joint. There was no causal evidence for the reverse direction. Future research could look more in depth into differences in the genetic variants that may represent different biological underlying mechanisms.

目的骨关节炎（OA）是一种全球范围内普遍存在的与残疾相关的慢性疾病，而肥胖是OA的一个关键可改变的危险因素。这项研究的目的是调查肥胖和OA之间的因果关系。方法采用双样本孟德尔随机化（MR）方法，以体重指数（BMI）为指标，探讨肥胖与膝、髋、手OA之间的双向因果关系。遗传工具来源于大规模的GWAS荟萃分析，包括681,000个体的BMI和827,000个体（177,000 OA病例）的OA。采用方差逆加权乘性随机效应分析作为主要分析方法，并基于不同假设进行敏感性分析。结果磁共振分析显示，基因预测的BMI对膝关节（OR 1.91, 95% CI 1.80-2.03）、髋关节（OR 1.52, 95% CI 1.41-1.64）和手部OA （OR 1.21, 95% CI 1.04-1.23）的风险增加有因果关系。敏感性分析证实了这些关联的稳健性。然而，没有证据表明膝关节、髋关节或手部OA对BMI有因果关系。结论：本研究提供了强有力的证据支持肥胖（以BMI衡量）对OA的因果影响，其中对负重膝关节的影响更为明显。髋关节和非负重手关节的比较。相反的方向没有因果证据。未来的研究可能会更深入地研究可能代表不同生物学潜在机制的遗传变异的差异。

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引用次数: 0