Pub Date : 2025-11-27DOI: 10.1016/j.ocarto.2025.100720
Tommy Frøseth Aae , Rune Bruhn Jakobsen , Mai Britt Dahl , Asbjørn Årøen , Per-Henrik Randsborg , Myrthle Slettvåg Hoel , Øystein Bjerkestrand Lian
Objective
This study aimed to determine whether physical activity or diurnal variation influence circulating microRNA-140-3p (miR-140-3p) and miR-140-5p expression levels in patients with knee osteoarthritis (OA) compared to healthy controls.
Method
Twenty-one patients with knee OA and ten healthy controls ran on a treadmill for 20 min and blood samples were taken prior to and after running. To assess diurnal variation, blood samples were drawn at six different times during a 24-h period. RNA was extracted from plasma and used for cDNA synthesis. Expression levels were assessed with real-time quantitative polymerase chain reaction and compared between patients and controls.
Results
All participants had detectable expression levels of miR-140-3p and miR-140-5p. A paired analysis could not demonstrate statistically significant differences between the groups.
Conclusions
Plasma miR-140-3p and miR-140-5p expression levels were found in all samples; however, the expression levels were not affected by physical activity and did not show diurnal variation. The observation of stable miR-140 expression supports its potential as a reliable biomarker for OA, providing a methodological foundation for future diagnostic and translational studies.
{"title":"Physical activity and diurnal variation have no impact on plasma microRNA-140 expression levels in patients with knee osteoarthritis and healthy controls","authors":"Tommy Frøseth Aae , Rune Bruhn Jakobsen , Mai Britt Dahl , Asbjørn Årøen , Per-Henrik Randsborg , Myrthle Slettvåg Hoel , Øystein Bjerkestrand Lian","doi":"10.1016/j.ocarto.2025.100720","DOIUrl":"10.1016/j.ocarto.2025.100720","url":null,"abstract":"<div><h3>Objective</h3><div>This study aimed to determine whether physical activity or diurnal variation influence circulating microRNA-140-3p (miR-140-3p) and miR-140-5p expression levels in patients with knee osteoarthritis (OA) compared to healthy controls.</div></div><div><h3>Method</h3><div>Twenty-one patients with knee OA and ten healthy controls ran on a treadmill for 20 min and blood samples were taken prior to and after running. To assess diurnal variation, blood samples were drawn at six different times during a 24-h period. RNA was extracted from plasma and used for cDNA synthesis. Expression levels were assessed with real-time quantitative polymerase chain reaction and compared between patients and controls.</div></div><div><h3>Results</h3><div>All participants had detectable expression levels of miR-140-3p and miR-140-5p. A paired analysis could not demonstrate statistically significant differences between the groups.</div></div><div><h3>Conclusions</h3><div>Plasma miR-140-3p and miR-140-5p expression levels were found in all samples; however, the expression levels were not affected by physical activity and did not show diurnal variation. The observation of stable miR-140 expression supports its potential as a reliable biomarker for OA, providing a methodological foundation for future diagnostic and translational studies.</div></div>","PeriodicalId":74377,"journal":{"name":"Osteoarthritis and cartilage open","volume":"8 1","pages":"Article 100720"},"PeriodicalIF":2.8,"publicationDate":"2025-11-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145693587","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-11-21DOI: 10.1016/j.ocarto.2025.100708
Birk M. Grønfeldt , Søren T. Skou , Jeanette W. Kirk , Anders Troelsen , Thomas Bandholm
Objective
Trials comparing the effectiveness of exercise-based rehabilitation against no exercise-based rehabilitation are needed, but their feasibility is unclear. The DRAW-TKA feasibility trial aimed to assess recruitment-, retention-, harms-, and procedural feasibility to inform a full-scale effectiveness trial.
Design
This pragmatic, multicentre, parallel, two-arm feasibility trial included participants scheduled for total knee arthroplasty due to osteoarthritis, aged ≥18, who could read and write Danish. Participants were recruited pre-operatively from two hospitals. At discharge, participants were encouraged to be physically active and randomised (one-to-one) to “Referral to exercise” (usual care) or “No exercise”. Recruiters, outcome assessors, and intervention-deliverers were masked to allocation. The primary feasibility criteria were based on recruitment rate, retention, participation barriers, and data completeness. Secondary criteria on harms, procedural feasibility, and intervention acceptance.
Results
Between Aug 22nd, 2023, and Feb 29th, 2024, all 445 patients planned for TKA were screened, of whom 338 (76 %) were ineligible, 49 of 107 eligible (45·8 %) declined participation (wanted exercise), and 25 of 107 (23·4 %) were randomly assigned exercise (n = 12) or no exercise (n = 13). Because of intervention-specific withdrawals (n = 3) and attrition, 18 of 25 completed all three-month assessments. Three of four predefined, primary feasibility criteria were met. Clinicians and participants found the trial procedurally feasible and acceptable. No interventional harms occurred.
Conclusion
The trial's scientific rationale – allocation to exercise, or no exercise – introduced significant risk of selection and attrition bias in this clinical context, severely limiting the generalisability. Although recruitment was predominantly feasible, further adaptations are required to warrant full-scale initiation.
{"title":"Feasibility of a randomized trial comparing exercise-based rehabilitation to no exercise-based rehabilitation after total knee arthroplasty: DRAW-TKA hybrid 1 RCT","authors":"Birk M. Grønfeldt , Søren T. Skou , Jeanette W. Kirk , Anders Troelsen , Thomas Bandholm","doi":"10.1016/j.ocarto.2025.100708","DOIUrl":"10.1016/j.ocarto.2025.100708","url":null,"abstract":"<div><h3>Objective</h3><div>Trials comparing the effectiveness of exercise-based rehabilitation against no exercise-based rehabilitation are needed, but their feasibility is unclear. The DRAW-TKA feasibility trial aimed to assess recruitment-, retention-, harms-, and procedural feasibility to inform a full-scale effectiveness trial.</div></div><div><h3>Design</h3><div>This pragmatic, multicentre, parallel, two-arm feasibility trial included participants scheduled for total knee arthroplasty due to osteoarthritis, aged ≥18, who could read and write Danish. Participants were recruited pre-operatively from two hospitals. At discharge, participants were encouraged to be physically active and randomised (one-to-one) to “Referral to exercise” (usual care) or “No exercise”. Recruiters, outcome assessors, and intervention-deliverers were masked to allocation. The primary feasibility criteria were based on recruitment rate, retention, participation barriers, and data completeness. Secondary criteria on harms, procedural feasibility, and intervention acceptance.</div></div><div><h3>Results</h3><div>Between Aug 22nd<sup>,</sup> 2023, and Feb 29th<sup>,</sup> 2024, all 445 patients planned for TKA were screened, of whom 338 (76 %) were ineligible, 49 of 107 eligible (45·8 %) declined participation (wanted exercise), and 25 of 107 (23·4 %) were randomly assigned exercise (n = 12) or no exercise (n = 13). Because of intervention-specific withdrawals (n = 3) and attrition, 18 of 25 completed all three-month assessments. Three of four predefined, primary feasibility criteria were met. Clinicians and participants found the trial procedurally feasible and acceptable. No interventional harms occurred.</div></div><div><h3>Conclusion</h3><div>The trial's scientific rationale – allocation to exercise, or no exercise – introduced significant risk of selection and attrition bias in this clinical context, severely limiting the generalisability. Although recruitment was predominantly feasible, further adaptations are required to warrant full-scale initiation.</div><div>NCT05935020.</div></div>","PeriodicalId":74377,"journal":{"name":"Osteoarthritis and cartilage open","volume":"8 1","pages":"Article 100708"},"PeriodicalIF":2.8,"publicationDate":"2025-11-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145694223","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-11-21DOI: 10.1016/j.ocarto.2025.100711
Trevor A. Lentz , Preston Roundy , Emily Poehlein , Cynthia L. Green , Richard C. Mather III , William Jiranek
Objective
This study describes the 2-year self-reported joint function outcomes of patients enrolled in a US-based comprehensive hip and knee osteoarthritis management program (OAMP), and demographic characteristics associated with change in function.
Design
This is a retrospective analysis of 598 patients with hip OA and 1533 patients with knee OA enrolled in the program between October 2017 and October 2024. Outcome measures for joint function (HOOS JR and KOOS JR) were collected via questionnaire at baseline, 6 weeks, 3 months, 6 months, 12 months, and 2 years after program enrollment. Generalized estimating equations (GEE) were used to describe trends in outcomes over time, and Kaplan Meier curves were constructed to assess time to meet minimal clinically important difference (MCID) thresholds. We conducted sensitivity analyses including several imputation strategies to address follow-up non-response. Interaction terms between timepoint and age, sex, race, and employment status were included in the covariate adjusted model.
Results
We observed statistically significant improvements in joint function over time for both hip and knee patients, and these significant improvements persisted in each sensitivity analysis. By 2 years, 61 % of knee patients and 60 % of hip patients met established MCIDs. Employment status, sex, and baseline function were associated with the trajectory of HOOS JR score.
Conclusions
Patients enrolled in this US-based OAMP experienced improvements, on average, for hip and knee symptoms, with most patients meeting clinically meaningful improvement thresholds by 2 years. These findings suggest that comprehensive OAMPs may offer an effective alternative to surgery.
{"title":"Patient-reported outcomes of a comprehensive management program for osteoarthritis of the hip and knee","authors":"Trevor A. Lentz , Preston Roundy , Emily Poehlein , Cynthia L. Green , Richard C. Mather III , William Jiranek","doi":"10.1016/j.ocarto.2025.100711","DOIUrl":"10.1016/j.ocarto.2025.100711","url":null,"abstract":"<div><h3>Objective</h3><div>This study describes the 2-year self-reported joint function outcomes of patients enrolled in a US-based comprehensive hip and knee osteoarthritis management program (OAMP), and demographic characteristics associated with change in function.</div></div><div><h3>Design</h3><div>This is a retrospective analysis of 598 patients with hip OA and 1533 patients with knee OA enrolled in the program between October 2017 and October 2024. Outcome measures for joint function (HOOS JR and KOOS JR) were collected via questionnaire at baseline, 6 weeks, 3 months, 6 months, 12 months, and 2 years after program enrollment. Generalized estimating equations (GEE) were used to describe trends in outcomes over time, and Kaplan Meier curves were constructed to assess time to meet minimal clinically important difference (MCID) thresholds. We conducted sensitivity analyses including several imputation strategies to address follow-up non-response. Interaction terms between timepoint and age, sex, race, and employment status were included in the covariate adjusted model.</div></div><div><h3>Results</h3><div>We observed statistically significant improvements in joint function over time for both hip and knee patients, and these significant improvements persisted in each sensitivity analysis. By 2 years, 61 % of knee patients and 60 % of hip patients met established MCIDs. Employment status, sex, and baseline function were associated with the trajectory of HOOS JR score.</div></div><div><h3>Conclusions</h3><div>Patients enrolled in this US-based OAMP experienced improvements, on average, for hip and knee symptoms, with most patients meeting clinically meaningful improvement thresholds by 2 years. These findings suggest that comprehensive OAMPs may offer an effective alternative to surgery.</div></div>","PeriodicalId":74377,"journal":{"name":"Osteoarthritis and cartilage open","volume":"8 1","pages":"Article 100711"},"PeriodicalIF":2.8,"publicationDate":"2025-11-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145694224","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-11-20DOI: 10.1016/j.ocarto.2025.100710
Alireza Savadipour , Gabrielle K. Marushack , Robert J. Nims , Jaquelin M. Garcia-Castorena , Wolfgang Liedtke , Farshid Guilak
Objective
One of the primary factors contributing to OA development is altered or excessive mechanical stress on the joint, which chondrocytes sense in part through the PIEZO mechanosensitive ion channels. These channels activate signaling pathways that result in joint inflammation and cartilage degeneration. In addition to PIEZO channels, voltage-gated calcium (Ca2+) channels (VGCCs) have been shown to contribute to Ca2+ influx into chondrocytes in response to mechanical loads.
Design
To better understand the relationship between PIEZO1 and VGCCs, we quantified porcine chondrocytes' intracellular Ca2+ response to mechanical loading or Yoda1 (a PIEZO1 agonist) after various classes of VGCCs were chemically inhibited. We also studied the effects of VGCC blockers on chondrocyte viability in porcine cartilage explants subjected to mechanical compression.
Results
In primary chondrocytes, nifedipine, an L-type VGCC blocker, reduced PIEZO1 sensitivity to both mechanical compression and pharmacological agonism, while NNC-55, a T-type VGCC blocker, increased PIEZO1 activation in response to both stimuli. Similarly, treating cartilage explants exposed to injurious mechanical loads with nifedipine reduced mechanically induced cell death compared to the control, while treatment with NNC-55 increased cell death.
Conclusions
In addition to contributing to the current understanding of the mechanisms through which VGCCs modify chondrocyte mechanobiology, our findings suggest the potential of L-type VGCC inhibitors as therapeutic targets for decreasing PIEZO1 signaling and reducing chondrocyte death in response to supraphysiologic mechanical loads.
{"title":"PIEZO mechanosensitivity in chondrocytes is differentially modulated by L-type and T-type voltage-sensitive ion channels","authors":"Alireza Savadipour , Gabrielle K. Marushack , Robert J. Nims , Jaquelin M. Garcia-Castorena , Wolfgang Liedtke , Farshid Guilak","doi":"10.1016/j.ocarto.2025.100710","DOIUrl":"10.1016/j.ocarto.2025.100710","url":null,"abstract":"<div><h3>Objective</h3><div>One of the primary factors contributing to OA development is altered or excessive mechanical stress on the joint, which chondrocytes sense in part through the PIEZO mechanosensitive ion channels. These channels activate signaling pathways that result in joint inflammation and cartilage degeneration. In addition to PIEZO channels, voltage-gated calcium (Ca<sup>2+</sup>) channels (VGCCs) have been shown to contribute to Ca<sup>2+</sup> influx into chondrocytes in response to mechanical loads.</div></div><div><h3>Design</h3><div>To better understand the relationship between PIEZO1 and VGCCs, we quantified porcine chondrocytes' intracellular Ca<sup>2+</sup> response to mechanical loading or Yoda1 (a PIEZO1 agonist) after various classes of VGCCs were chemically inhibited. We also studied the effects of VGCC blockers on chondrocyte viability in porcine cartilage explants subjected to mechanical compression.</div></div><div><h3>Results</h3><div>In primary chondrocytes, nifedipine, an L-type VGCC blocker, reduced PIEZO1 sensitivity to both mechanical compression and pharmacological agonism, while NNC-55, a T-type VGCC blocker, increased PIEZO1 activation in response to both stimuli. Similarly, treating cartilage explants exposed to injurious mechanical loads with nifedipine reduced mechanically induced cell death compared to the control, while treatment with NNC-55 increased cell death.</div></div><div><h3>Conclusions</h3><div>In addition to contributing to the current understanding of the mechanisms through which VGCCs modify chondrocyte mechanobiology, our findings suggest the potential of L-type VGCC inhibitors as therapeutic targets for decreasing PIEZO1 signaling and reducing chondrocyte death in response to supraphysiologic mechanical loads.</div></div>","PeriodicalId":74377,"journal":{"name":"Osteoarthritis and cartilage open","volume":"8 1","pages":"Article 100710"},"PeriodicalIF":2.8,"publicationDate":"2025-11-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145624881","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-11-19DOI: 10.1016/j.ocarto.2025.100707
Ralf Henkelmann , Raphael Greifeldt , Pierre Hepp , Robert Hennings , Hans-Jonas Meyer , Timm Denecke , Jeanette Henkelmann
Objective
To investigate the association between coronal plane malalignment of the lower extremity and talar osteochondritis dissecans (OCD) localization, and assess the influence of mechanical axis deviations and local joint morphology on lesion distribution.
Design
This retrospective monocentric study included 50 patients (mean age 31 ± 12 years) with 52 talar OCD lesions who underwent standing whole-leg radiography, which were analyzed digitally. The primary outcome was OCD lesion localization (medial vs. lateral) in relation to coronal plane lower limb alignment (varus, neutral, valgus). Secondary outcomes included angular parameters of the knee and ankle (mLDFA, mMPTA, mLDTA, JLCA, KAJA, talar inclination, talar tilt) and associations lower limb alignment patterns with lesion location. Associations were assessed via univariate testing and binary logistic regression.
Results
Talar OCDs occurred medially in 83 % and laterally in 17 %. Lower limb malalignment was significantly associated with lesion localization (p = 0.024), with varus correlated with medial, while valgus predicted lateral OCD lesions (OR 2.63; 95 % CI 1.1–6.4; p = 0.034). Talar tilt independently correlated with lesion site (p < 0.001); tibiotalar valgus tilt increased odds for lateral lesions (OR 0.084; 95 % CI 0.01–0.73; p = 0.025). Combined knee and ankle alignment subtypes also influenced lesion laterality (p = 0.017).
Conclusions
Lower limb malalignment and talar tilt are independent predictors of OCD localization. Coronal plane deviations and joint morphology alter load across the talar dome, contributing to medial or lateral predilection. Whole-leg alignment analysis should be considered in diagnostic and surgical planning, particularly in revision cases.
目的探讨下肢冠状面畸形与距骨夹层炎（OCD）定位的关系，并探讨机械轴偏离和局部关节形态对病变分布的影响。这项回顾性单中心研究包括50例（平均年龄31±12岁）患52个距骨OCD病变的患者，他们接受了站立全腿x线摄影，并进行了数字分析。主要结果是OCD病变定位（内侧vs外侧）与冠状面下肢对齐（内翻，中性，外翻）的关系。次要结果包括膝关节和踝关节的角度参数（mLDFA、mMPTA、mLDTA、JLCA、KAJA、距骨倾斜、距骨倾斜）以及与病变位置相关的下肢对齐模式。通过单变量检验和二元逻辑回归评估相关性。结果星光性强迫症发生在内侧的占83%，外侧的占17%。下肢排列失调与病变定位显著相关（p = 0.024），内翻与内侧相关，外翻预测外侧OCD病变（OR 2.63; 95% CI 1.1-6.4; p = 0.034）。距骨倾斜与病变部位独立相关（p < 0.001）；胫距外翻倾斜增加外侧病变的几率（OR 0.084; 95% CI 0.01-0.73; p = 0.025）。膝关节和踝关节联合排列亚型也影响病变的侧边性（p = 0.017）。结论慢肢畸形和距骨倾斜是强迫症定位的独立预测因素。冠状面偏差和关节形态改变距骨穹隆的负荷，导致内侧或外侧偏向。在诊断和手术计划中应考虑全腿对齐分析，特别是在翻修病例中。
{"title":"Lower limb malalignment on whole-leg radiography predicts medial or lateral talar osteochondral lesion location: Implications for osteoarthritis assessment","authors":"Ralf Henkelmann , Raphael Greifeldt , Pierre Hepp , Robert Hennings , Hans-Jonas Meyer , Timm Denecke , Jeanette Henkelmann","doi":"10.1016/j.ocarto.2025.100707","DOIUrl":"10.1016/j.ocarto.2025.100707","url":null,"abstract":"<div><h3>Objective</h3><div>To investigate the association between coronal plane malalignment of the lower extremity and talar osteochondritis dissecans (OCD) localization, and assess the influence of mechanical axis deviations and local joint morphology on lesion distribution.</div></div><div><h3>Design</h3><div>This retrospective monocentric study included 50 patients (mean age 31 ± 12 years) with 52 talar OCD lesions who underwent standing whole-leg radiography, which were analyzed digitally. The primary outcome was OCD lesion localization (medial vs. lateral) in relation to coronal plane lower limb alignment (varus, neutral, valgus). Secondary outcomes included angular parameters of the knee and ankle (mLDFA, mMPTA, mLDTA, JLCA, KAJA, talar inclination, talar tilt) and associations lower limb alignment patterns with lesion location. Associations were assessed via univariate testing and binary logistic regression.</div></div><div><h3>Results</h3><div>Talar OCDs occurred medially in 83 % and laterally in 17 %. Lower limb malalignment was significantly associated with lesion localization (p = 0.024), with varus correlated with medial, while valgus predicted lateral OCD lesions (OR 2.63; 95 % CI 1.1–6.4; p = 0.034). Talar tilt independently correlated with lesion site (p < 0.001); tibiotalar valgus tilt increased odds for lateral lesions (OR 0.084; 95 % CI 0.01–0.73; p = 0.025). Combined knee and ankle alignment subtypes also influenced lesion laterality (p = 0.017).</div></div><div><h3>Conclusions</h3><div>Lower limb malalignment and talar tilt are independent predictors of OCD localization. Coronal plane deviations and joint morphology alter load across the talar dome, contributing to medial or lateral predilection. Whole-leg alignment analysis should be considered in diagnostic and surgical planning, particularly in revision cases.</div></div>","PeriodicalId":74377,"journal":{"name":"Osteoarthritis and cartilage open","volume":"8 1","pages":"Article 100707"},"PeriodicalIF":2.8,"publicationDate":"2025-11-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145694226","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-11-19DOI: 10.1016/j.ocarto.2025.100706
Kim L. Bennell , Jesse J. Pardo , Rana S. Hinman , Christopher B. Little , Carina L. Blaker , Jocelyn L. Bowden , Belinda J. Lawford , Ben Metcalf , Neil Bidgood , Carolyn Yii , Sarah Stratulate , David J. Hunter
Objective
To identify research priorities for osteoarthritis (OA) in Australia to reduce the individual and societal burden of OA.
Design
We used accepted priority setting methodology involving multiple stages: 1) gathering unanswered research priorities from selected literature; 2) assembling an expert panel and using an online survey to obtain additional priorities from panelists; 3) consolidating research priorities (eg. removing duplicates); 4) panel rating of priorities for importance on an 11-point numeric rating scale (0 = ‘not at all important; 10 = ‘extremely important’) via another online survey; 5) analyzing and compiling the final list of priorities; and 6) addressing implementation via a one-day National Summit.
Results
38 research priorities were identified from the literature. 288 nation-wide panel experts (204 consumers/carers/consumer organisations; 47 clinicians from 9 disciplines; 32 researchers; and 5 industry/research funders) provided an additional 99 priorities. Following consolidation, 90 priorities remained and were organised under 8 themes. 204 of the original panelists (71 %) rated the priorities. All priorities scored a mean importance rating ≥6 and so were retained, giving a final list of 90. Mean (SD) importance scores for the top 20 priorities ranged from 8.2 (1.9) to 8.9 (1.9). Overall, the top 3 priorities related to developing drugs/strategies to prevent disease progression and regeneration of damaged cartilage. There was variation across consumers, clinicians and researchers, with only 2 of the same priorities ranked in each of their top 20.
Conclusions
We determined key research priorities for OA. These can help guide research directions and funding to enhance outcomes for people with OA.
{"title":"Reducing the burden of osteoarthritis in Australia: A 2024–2025 research priority-setting study","authors":"Kim L. Bennell , Jesse J. Pardo , Rana S. Hinman , Christopher B. Little , Carina L. Blaker , Jocelyn L. Bowden , Belinda J. Lawford , Ben Metcalf , Neil Bidgood , Carolyn Yii , Sarah Stratulate , David J. Hunter","doi":"10.1016/j.ocarto.2025.100706","DOIUrl":"10.1016/j.ocarto.2025.100706","url":null,"abstract":"<div><h3>Objective</h3><div>To identify research priorities for osteoarthritis (OA) in Australia to reduce the individual and societal burden of OA.</div></div><div><h3>Design</h3><div>We used accepted priority setting methodology involving multiple stages: 1) gathering unanswered research priorities from selected literature; 2) assembling an expert panel and using an online survey to obtain additional priorities from panelists; 3) consolidating research priorities (eg. removing duplicates); 4) panel rating of priorities for importance on an 11-point numeric rating scale (0 = ‘not at all important; 10 = ‘extremely important’) via another online survey; 5) analyzing and compiling the final list of priorities; and 6) addressing implementation via a one-day National Summit.</div></div><div><h3>Results</h3><div>38 research priorities were identified from the literature. 288 nation-wide panel experts (204 consumers/carers/consumer organisations; 47 clinicians from 9 disciplines; 32 researchers; and 5 industry/research funders) provided an additional 99 priorities. Following consolidation, 90 priorities remained and were organised under 8 themes. 204 of the original panelists (71 %) rated the priorities. All priorities scored a mean importance rating ≥6 and so were retained, giving a final list of 90. Mean (SD) importance scores for the top 20 priorities ranged from 8.2 (1.9) to 8.9 (1.9). Overall, the top 3 priorities related to developing drugs/strategies to prevent disease progression and regeneration of damaged cartilage. There was variation across consumers, clinicians and researchers, with only 2 of the same priorities ranked in each of their top 20.</div></div><div><h3>Conclusions</h3><div>We determined key research priorities for OA. These can help guide research directions and funding to enhance outcomes for people with OA.</div></div>","PeriodicalId":74377,"journal":{"name":"Osteoarthritis and cartilage open","volume":"8 1","pages":"Article 100706"},"PeriodicalIF":2.8,"publicationDate":"2025-11-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145624880","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-11-17DOI: 10.1016/j.ocarto.2025.100704
E.R. Vina , L. Stauber , C. Villamil Grest , R.A. Gomez , F. Razzaq , J. Dagnino , K.L. Bennell , C.K. Kwoh
Objective
Identify facilitators and barriers to engaging in exercise or other physical activity (PA) programs among Hispanics with knee OA (osteoarthritis) and to inform the development of a dyadic telehealth-delivered program.
Design
Hispanics with symptomatic knee OA were recruited. Participants were asked to invite a family member/friend to join them in a semi-structured Zoom interview. Interviews, guided by the Theoretical Domains Framework of behavior change, explored participants' beliefs about exercise and identified barriers and facilitators to engaging in exercise or other PA programs. Transcripts were analyzed primarily using deductive content analysis in MAXQDA 2024.
Results
Interviews were conducted with 8 female and 7 male patients (mean age: 67.7 years) and their chosen partners (10 spouses, 3 friends, 2 relatives). The most frequently mentioned facilitator of PA program uptake was participants' expectation that exercise would lead to positive outcomes, including improvement of OA-related symptoms. Another key facilitator to engaging in a PA intervention was access to professional guidance—both for initiating and implementing the program. Participants highlighted the importance of receiving prescriptions from providers and expert guidance (e.g., physical therapists). Barriers to participation were not prominent. There were limited concerns about telehealth navigation for most. However, some expressed lack of concordance with partner schedule and incompatible exercise pace/style as potential barriers.
Conclusions
A telehealth PA intervention for knee OA would be well-received by Hispanics in the US southwest, particularly when prescribed and overseen by healthcare providers. Barriers to intervention participation were limited but included discordance with partner schedule and exercise pace.
{"title":"Hispanic American osteoarthritis patients' and partners' perspectives regarding exercise: A qualitative study","authors":"E.R. Vina , L. Stauber , C. Villamil Grest , R.A. Gomez , F. Razzaq , J. Dagnino , K.L. Bennell , C.K. Kwoh","doi":"10.1016/j.ocarto.2025.100704","DOIUrl":"10.1016/j.ocarto.2025.100704","url":null,"abstract":"<div><h3>Objective</h3><div>Identify facilitators and barriers to engaging in exercise or other physical activity (PA) programs among Hispanics with knee OA (osteoarthritis) and to inform the development of a dyadic telehealth-delivered program.</div></div><div><h3>Design</h3><div>Hispanics with symptomatic knee OA were recruited. Participants were asked to invite a family member/friend to join them in a semi-structured Zoom interview. Interviews, guided by the Theoretical Domains Framework of behavior change, explored participants' beliefs about exercise and identified barriers and facilitators to engaging in exercise or other PA programs. Transcripts were analyzed primarily using deductive content analysis in MAXQDA 2024.</div></div><div><h3>Results</h3><div>Interviews were conducted with 8 female and 7 male patients (mean age: 67.7 years) and their chosen partners (10 spouses, 3 friends, 2 relatives). The most frequently mentioned facilitator of PA program uptake was participants' expectation that exercise would lead to positive outcomes, including improvement of OA-related symptoms. Another key facilitator to engaging in a PA intervention was access to professional guidance—both for initiating and implementing the program. Participants highlighted the importance of receiving prescriptions from providers and expert guidance (e.g., physical therapists). Barriers to participation were not prominent. There were limited concerns about telehealth navigation for most. However, some expressed lack of concordance with partner schedule and incompatible exercise pace/style as potential barriers.</div></div><div><h3>Conclusions</h3><div>A telehealth PA intervention for knee OA would be well-received by Hispanics in the US southwest, particularly when prescribed and overseen by healthcare providers. Barriers to intervention participation were limited but included discordance with partner schedule and exercise pace.</div></div>","PeriodicalId":74377,"journal":{"name":"Osteoarthritis and cartilage open","volume":"8 1","pages":"Article 100704"},"PeriodicalIF":2.8,"publicationDate":"2025-11-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145579929","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-11-13DOI: 10.1016/j.ocarto.2025.100709
Mengjie Zeng, Flavia M. Cicuttini, Angus Franks, John J. McNeil, Yuanyuan Wang
Objective
To examined whether metabolic syndrome (MetS) and accumulation of its components were associated with incidence of knee and hip replacement for osteoarthritis in community-dwelling older individuals.
Design
This study examined 9179 women and 7524 men from the ASPREE trial. MetS was defined if at least three of the five criteria were present: central obesity, elevated triglyceride, reduced high-density lipoprotein cholesterol, hypertension, and dysglycemia. Knee and hip replacement for osteoarthritis were defined by hospitalisations during the ASPREE trial for knee and hip surgical procedures with the indication recorded as osteoarthritis.
Results
Over a mean follow-up of 4.0 (standard deviation 1.4) years, 547 women and 346 men had knee replacements and 404 women and 290 men had hip replacements. Central obesity was associated with an increased risk of knee replacement in women [hazard ratio (HR) 1.62, 95 % confidence interval (CI) 1.26–2.10] but not men (HR 0.93, 95 % CI 0.70–1.23), independent of confounders including body mass index. MetS was independently associated with a decreased risk of hip replacement in men (HR 0.73, 95 % CI 0.57–0.95) but not women (HR 0.90, 95 % CI 0.73–1.12). Accumulation of MetS components was also associated with a decreased risk of hip replacement in men (p for trend 0.005) which was not seen in women (p for trend 0.94).
Conclusion
These findings suggest that targeting central obesity may reduce the risk of knee replacement in older women. The mechanism for the reduced risk of hip replacement in men associated with MetS and accumulation of MetS components is unclear and warrants further investigations.
目的探讨代谢综合征（MetS）及其成分的积累是否与社区老年人骨性关节炎的膝关节和髋关节置换术发生率相关。本研究检查了来自ASPREE试验的9179名女性和7524名男性。如果五项标准中至少有三项存在，则定义为MetS：中心性肥胖，甘油三酯升高，高密度脂蛋白胆固醇降低，高血压和血糖异常。在ASPREE试验期间，膝关节和髋关节手术的适应症记录为骨关节炎，膝关节和髋关节置换术是通过住院来定义的。结果平均随访4.0年（标准差1.4），547名女性和346名男性进行了膝关节置换术，404名女性和290名男性进行了髋关节置换术。中心性肥胖与女性膝关节置换术风险增加相关[风险比（HR） 1.62, 95%可信区间（CI） 1.26-2.10]，但与男性无关（HR 0.93, 95% CI 0.70-1.23），与体重指数等混杂因素无关。met与男性髋关节置换术风险降低独立相关（HR 0.73, 95% CI 0.57-0.95），但与女性无关（HR 0.90, 95% CI 0.73 - 1.12）。MetS成分的积累也与男性髋关节置换术风险降低相关（p为趋势0.005），而在女性中未见（p为趋势0.94）。结论：针对中心性肥胖可降低老年妇女膝关节置换术的风险。与MetS和MetS成分积累相关的男性髋关节置换术风险降低的机制尚不清楚，值得进一步研究。
{"title":"Metabolic syndrome, accumulation of its components and risk of knee and hip replacement for osteoarthritis in community-dwelling older adults","authors":"Mengjie Zeng, Flavia M. Cicuttini, Angus Franks, John J. McNeil, Yuanyuan Wang","doi":"10.1016/j.ocarto.2025.100709","DOIUrl":"10.1016/j.ocarto.2025.100709","url":null,"abstract":"<div><h3>Objective</h3><div>To examined whether metabolic syndrome (MetS) and accumulation of its components were associated with incidence of knee and hip replacement for osteoarthritis in community-dwelling older individuals.</div></div><div><h3>Design</h3><div>This study examined 9179 women and 7524 men from the ASPREE trial. MetS was defined if at least three of the five criteria were present: central obesity, elevated triglyceride, reduced high-density lipoprotein cholesterol, hypertension, and dysglycemia. Knee and hip replacement for osteoarthritis were defined by hospitalisations during the ASPREE trial for knee and hip surgical procedures with the indication recorded as osteoarthritis.</div></div><div><h3>Results</h3><div>Over a mean follow-up of 4.0 (standard deviation 1.4) years, 547 women and 346 men had knee replacements and 404 women and 290 men had hip replacements. Central obesity was associated with an increased risk of knee replacement in women [hazard ratio (HR) 1.62, 95 % confidence interval (CI) 1.26–2.10] but not men (HR 0.93, 95 % CI 0.70–1.23), independent of confounders including body mass index. MetS was independently associated with a decreased risk of hip replacement in men (HR 0.73, 95 % CI 0.57–0.95) but not women (HR 0.90, 95 % CI 0.73–1.12). Accumulation of MetS components was also associated with a decreased risk of hip replacement in men (p for trend 0.005) which was not seen in women (p for trend 0.94).</div></div><div><h3>Conclusion</h3><div>These findings suggest that targeting central obesity may reduce the risk of knee replacement in older women. The mechanism for the reduced risk of hip replacement in men associated with MetS and accumulation of MetS components is unclear and warrants further investigations.</div></div>","PeriodicalId":74377,"journal":{"name":"Osteoarthritis and cartilage open","volume":"8 1","pages":"Article 100709"},"PeriodicalIF":2.8,"publicationDate":"2025-11-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145555506","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-11-13DOI: 10.1016/j.ocarto.2025.100703
Aerman Nuer , Yasi Yang , Boran Sun , Yunhan Wang , Wenbo Xiao , Lei Wang , Shu Wang , Wenli Lu
Background
Knee osteoarthritis (KOA) is a chronic disorder marked by progressive cartilage loss and functional decline. Current classifications miss bidirectional transitions, particularly in early and late stages, hindering early intervention.
Methods
Participants aged 45–79 years from the Osteoarthritis Initiative (OAI) were analyzed over eight years, classifying KOA states as normal, early-KOA, radiographic KOA (rKOA), and end-stage KOA (es-KOA) using Kellgren-Lawrence (K-L) grades, symptoms, and patient-reported outcomes. A Multi-state Markov (MSM) model evaluated state transitions and risk factors.
Results
The study comprised 2043 individuals (55.0 % female, 85.9 % White) with a total of 13,997 records of KOA state assessment. Of the individuals currently classified as early-KOA, 34.0 % returned to normal state, 60.9 % remained in early-KOA, and 5.1 % progressed to rKOA or es-KOA at next follow-up. The transition intensity from early-KOA to rKOA (0.05, 95 % CI: 0.04–0.06) was 2.6 times greater than that from normal to rKOA (0.02, 95 % CI: 0.01–0.02). The longest sojourn time was observed in rKOA, with a mean of 15.17 years. In covariate analysis, progression risk increased with obesity (HR: 2.57, Normal to rKOA), poor contralateral knee condition (HR: 3.68, Normal to rKOA), and depressive symptoms (HR: 2.16, rKOA to es-KOA). Better physical function reduced risk (HR: 0.65, Normal to early-KOA).
Conclusion
This study reveals dynamic KOA transitions, with early-KOA and es-KOA showing recovery potential. Identifying risk factors like obesity and contralateral knee condition offers opportunities for targeted interventions to slow progression and improve joint health, emphasizing early management's role in KOA care.
{"title":"Progression and influencing factors of knee osteoarthritis based on a multi-state Markov model: Data from OAI","authors":"Aerman Nuer , Yasi Yang , Boran Sun , Yunhan Wang , Wenbo Xiao , Lei Wang , Shu Wang , Wenli Lu","doi":"10.1016/j.ocarto.2025.100703","DOIUrl":"10.1016/j.ocarto.2025.100703","url":null,"abstract":"<div><h3>Background</h3><div>Knee osteoarthritis (KOA) is a chronic disorder marked by progressive cartilage loss and functional decline. Current classifications miss bidirectional transitions, particularly in early and late stages, hindering early intervention.</div></div><div><h3>Methods</h3><div>Participants aged 45–79 years from the Osteoarthritis Initiative (OAI) were analyzed over eight years, classifying KOA states as normal, early-KOA, radiographic KOA (rKOA), and end-stage KOA (es-KOA) using Kellgren-Lawrence (K-L) grades, symptoms, and patient-reported outcomes. A Multi-state Markov (MSM) model evaluated state transitions and risk factors.</div></div><div><h3>Results</h3><div>The study comprised 2043 individuals (55.0 % female, 85.9 % White) with a total of 13,997 records of KOA state assessment. Of the individuals currently classified as early-KOA, 34.0 % returned to normal state, 60.9 % remained in early-KOA, and 5.1 % progressed to rKOA or es-KOA at next follow-up. The transition intensity from early-KOA to rKOA (0.05, 95 % CI: 0.04–0.06) was 2.6 times greater than that from normal to rKOA (0.02, 95 % CI: 0.01–0.02). The longest sojourn time was observed in rKOA, with a mean of 15.17 years. In covariate analysis, progression risk increased with obesity (HR: 2.57, Normal to rKOA), poor contralateral knee condition (HR: 3.68, Normal to rKOA), and depressive symptoms (HR: 2.16, rKOA to es-KOA). Better physical function reduced risk (HR: 0.65, Normal to early-KOA).</div></div><div><h3>Conclusion</h3><div>This study reveals dynamic KOA transitions, with early-KOA and es-KOA showing recovery potential. Identifying risk factors like obesity and contralateral knee condition offers opportunities for targeted interventions to slow progression and improve joint health, emphasizing early management's role in KOA care.</div></div>","PeriodicalId":74377,"journal":{"name":"Osteoarthritis and cartilage open","volume":"8 1","pages":"Article 100703"},"PeriodicalIF":2.8,"publicationDate":"2025-11-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145555507","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-11-13DOI: 10.1016/j.ocarto.2025.100705
Daniel I. Rhon , Maggie E. Horn , Rebecca Milan , Steven Z. George
Objective
To characterize healthcare utilization in a younger population with glenohumeral osteoarthritis.
Methods
Adults seeking care for glenohumeral osteoarthritis between July 2013 and March 2019 were analyzed. Ambulatory visits, pharmacological, and non-pharmacological treatment, and surgical and radiological procedures, were compared by active-duty status and sex. The association between exercise therapy receipt and subsequent surgery was modeled using an adjusted logistic regression, reporting adjusted odds ratios (OR).
Results
There were 21,369 individuals (29.4 % female; mean age 50.3 [standard deviation (SD) 9.9] years), with 24.1 % military patients. The mean number of ambulatory shoulder visits per patient was 9.4 (SD 12.5). For pharmacological care 26.2 % received an injection, 14.8 % received non-steroidal anti-inflammatory drugs, 13.4 % opioids, 11.8 % muscle relaxants, and 9.9 % other analgesics. Non-pharmacological care included 44.5 % receiving exercise therapy, 41.6 % physiotherapy, and 32.6 % manual therapy, while 54.0 % received none of these. Radiographs were obtained for 51.3 % and advanced imaging for 47.1 %. Arthroscopic surgery occurred in 18.9 % and arthroplasty in 0.2 %. Military patients received less pharmacological and more non-pharmacological treatment that non-military patients. Males had 1.5x the odds of surgery and higher pharmacological treatment use than females. Receipt of exercise therapy (adjusted OR = 0.01; 95 % confidence interval 0.01, 0.02) significantly reduced the odds of arthroscopic surgery.
Conclusion
Many patients received no interventions. For those receiving care, <50 % received guideline-recommended non-pharmacological care, including exercise therapy which significantly reduced the likelihood of surgery. Military patients had overall less pharmacological but more non-pharmacological treatment than non-military patients. A greater frequency of males had surgery. These findings indicate the need to further explore health care delivery for glenohumeral osteoarthritis in younger populations, highlighting potential guideline to practice gaps.
{"title":"Management of glenohumeral osteoarthritis in the younger patient: A population level analysis of usual care delivery in a large health system","authors":"Daniel I. Rhon , Maggie E. Horn , Rebecca Milan , Steven Z. George","doi":"10.1016/j.ocarto.2025.100705","DOIUrl":"10.1016/j.ocarto.2025.100705","url":null,"abstract":"<div><h3>Objective</h3><div>To characterize healthcare utilization in a younger population with glenohumeral osteoarthritis.</div></div><div><h3>Methods</h3><div>Adults seeking care for glenohumeral osteoarthritis between July 2013 and March 2019 were analyzed. Ambulatory visits, pharmacological, and non-pharmacological treatment, and surgical and radiological procedures, were compared by active-duty status and sex. The association between exercise therapy receipt and subsequent surgery was modeled using an adjusted logistic regression, reporting adjusted odds ratios (OR).</div></div><div><h3>Results</h3><div>There were 21,369 individuals (29.4 % female; mean age 50.3 [standard deviation (SD) 9.9] years), with 24.1 % military patients. The mean number of ambulatory shoulder visits per patient was 9.4 (SD 12.5). For pharmacological care 26.2 % received an injection, 14.8 % received non-steroidal anti-inflammatory drugs, 13.4 % opioids, 11.8 % muscle relaxants, and 9.9 % other analgesics. Non-pharmacological care included 44.5 % receiving exercise therapy, 41.6 % physiotherapy, and 32.6 % manual therapy, while 54.0 % received none of these. Radiographs were obtained for 51.3 % and advanced imaging for 47.1 %. Arthroscopic surgery occurred in 18.9 % and arthroplasty in 0.2 %. Military patients received less pharmacological and more non-pharmacological treatment that non-military patients. Males had 1.5x the odds of surgery and higher pharmacological treatment use than females. Receipt of exercise therapy (adjusted OR = 0.01; 95 % confidence interval 0.01, 0.02) significantly reduced the odds of arthroscopic surgery.</div></div><div><h3>Conclusion</h3><div>Many patients received no interventions. For those receiving care, <50 % received guideline-recommended non-pharmacological care, including exercise therapy which significantly reduced the likelihood of surgery. Military patients had overall less pharmacological but more non-pharmacological treatment than non-military patients. A greater frequency of males had surgery. These findings indicate the need to further explore health care delivery for glenohumeral osteoarthritis in younger populations, highlighting potential guideline to practice gaps.</div></div>","PeriodicalId":74377,"journal":{"name":"Osteoarthritis and cartilage open","volume":"8 1","pages":"Article 100705"},"PeriodicalIF":2.8,"publicationDate":"2025-11-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145555508","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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