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Perspectives in medical virology最新文献

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Chapter 6 Virus Removal During Drinking Water Treatment 第六章饮用水处理过程中的病毒去除
Pub Date : 2007-01-01 DOI: 10.1016/S0168-7069(07)17006-3
S. Springthorpe, S. Sattar
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引用次数: 6
Chapter 13 Recent Advances and Future Needs in Environmental Virology. 第十三章环境病毒学的最新进展和未来需要。
Pub Date : 2007-01-01 Epub Date: 2007-09-06 DOI: 10.1016/S0168-7069(07)17013-0
Mark Wong, Irene Xagoraraki, Joan B Rose

The detection of viruses in water and other environmental samples constitutes special challenges. The standard method of detection of viral pathogens in environmental samples uses assays in mammalian cell culture. The infected cell cultures undergo observable morphological changes called cytopathogenic effects (CPEs) that are used for the detection of viruses. Even though many viruses are culturable in several cell lines and are thus detectable by the development of CPEs in cell culture, there are several viruses, like enteric waterborne adenoviruses types 40 and 41, which are difficult to culture and do not produce clear and consistent CPE. Other viruses, like waterborne caliciviruses, have not yet been successfully grown in cell cultures. Conventional cell culture assays for the detection of viruses in environmental samples have limited sensitivity and can be labor-intensive and timeconsuming. Two advances, the PCR and microarrays, have spurred the study of viruses and should be further applied to the field of environmental virology. The ability of both DNA viruses and RNA viruses to rapidly evolve means new and emerging viral pathogens will need to be addressed. Pathogen discovery and characterization, occurrence in the environment, exposure pathways, and health outcomes via environmental exposure need to be addressed. This will likely follow a new microbial risk framework that will require focused research on some important properties of viral disease transmission. The future will require models that examine community risks and provide explicit links between the models currently under development for environmental exposure and infectious disease.

在水和其他环境样本中检测病毒构成了特殊挑战。环境样品中病毒病原体检测的标准方法使用哺乳动物细胞培养试验。受感染的细胞培养物发生可观察到的形态变化,称为细胞致病效应(cpe),用于检测病毒。尽管许多病毒可以在几种细胞系中培养,因此可以通过细胞培养中CPE的发育来检测,但有几种病毒,如肠道水传播腺病毒40型和41型,很难培养,并且不能产生清晰和一致的CPE。其他病毒,如水传播的杯状病毒,尚未在细胞培养中成功培养。用于检测环境样品中病毒的传统细胞培养分析灵敏度有限,而且可能是劳动密集型和耗时的。PCR技术和微阵列技术的发展促进了病毒研究的发展,在环境病毒学领域有进一步的应用前景。DNA病毒和RNA病毒都具有快速进化的能力,这意味着需要解决新的和正在出现的病毒病原体。需要解决病原体的发现和特征、环境中的发生、暴露途径以及环境暴露带来的健康后果。这可能会遵循一个新的微生物风险框架,这将需要对病毒疾病传播的一些重要特性进行重点研究。未来将需要审查社区风险的模型,并在目前正在开发的环境暴露与传染病模型之间提供明确的联系。
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引用次数: 7
Chapter 10 Viruses in Shellfish 第10章贝类中的病毒
Pub Date : 2007-01-01 DOI: 10.1016/S0168-7069(07)17010-5
F. Guyader, R. Atmar
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引用次数: 15
Index. 索引。
Pub Date : 2007-01-01 Epub Date: 2007-09-06 DOI: 10.1016/S0168-7069(07)17015-4
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引用次数: 0
Chapter 5 Virus Occurrence and Survival in the Environmental Waters 第五章病毒在环境水体中的发生与生存
Pub Date : 2007-01-01 DOI: 10.1016/S0168-7069(07)17005-1
C. Gerba
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引用次数: 33
Varicella-Zoster Virus Infections during Pregnancy 妊娠期水痘带状疱疹病毒感染
Pub Date : 2006-12-31 DOI: 10.1016/S0168-7069(06)13004-9
A. Sauerbrei
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引用次数: 7
Development of Antivirals against Respiratory Syncytial Virus 呼吸道合胞病毒抗病毒药物的研究进展
Pub Date : 2006-12-31 DOI: 10.1016/S0168-7069(06)14009-4
K. Powell, D. Alber
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引用次数: 6
Colour Section 颜色部分
Pub Date : 2006-11-28 DOI: 10.1016/s0168-7069(06)14014-8
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引用次数: 0
Pathogenesis of RSV in Children 儿童呼吸道合胞病毒发病机制
Pub Date : 2006-11-16 DOI: 10.1016/S0168-7069(06)14005-7
S. Brearey, R. Smyth
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引用次数: 9
Serologic Testing for Acute and Chronic Infection 急性和慢性感染的血清学检测
Pub Date : 2006-01-01 DOI: 10.1016/S0168-7069(06)12007-8
H. Agut, A. Gautheret-Dejean
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引用次数: 0
期刊
Perspectives in medical virology
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