{"title":"Placenta and Reproductive Medicine: A Resource for Maternal and Fetal Health","authors":"N. Zhong, C. Qiao","doi":"10.54844/prm.2022.0107","DOIUrl":"https://doi.org/10.54844/prm.2022.0107","url":null,"abstract":"","PeriodicalId":74455,"journal":{"name":"Placenta and reproductive medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-07-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44318050","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Cell culture and organ explant systems have traditionally been used by scientists in the reproductive biology and perinatal medicine area to address various research questions. Although most are unrelated to human pregnancy, animal models were also extensively used to study various mechanisms associated with pregnancy and parturition. However, limitations of traditional approaches have shifted the attention to the use of organ on a chip (OOC) technology. OOC platform simulates an organ using cells, and OOCs are biomimetic microfluidic systems comprising multiple cell types from an organ that mimic the environment of a physiological organ. OOC maintains intercellular interactions and helps to recreate organ physiology as expected for utero in perinatal medicine research. This short review introduces some basic concepts of OOC, and its utility based on some published reports.
{"title":"Organ-on-a-chip for perinatal biology experiments.","authors":"Ramkumar Menon, Lauren Richardson","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Cell culture and organ explant systems have traditionally been used by scientists in the reproductive biology and perinatal medicine area to address various research questions. Although most are unrelated to human pregnancy, animal models were also extensively used to study various mechanisms associated with pregnancy and parturition. However, limitations of traditional approaches have shifted the attention to the use of organ on a chip (OOC) technology. OOC platform simulates an organ using cells, and OOCs are biomimetic microfluidic systems comprising multiple cell types from an organ that mimic the environment of a physiological organ. OOC maintains intercellular interactions and helps to recreate organ physiology as expected for utero in perinatal medicine research. This short review introduces some basic concepts of OOC, and its utility based on some published reports.</p>","PeriodicalId":74455,"journal":{"name":"Placenta and reproductive medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-07-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/b8/14/nihms-1837043.PMC9757604.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10391531","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
While most intrauterine tissues are thoroughly studied for their role in pregnancy maintenance and their contribution to labor initiation, the fetal membranes (i.e., amniochorionic membranes) are primarily overlooked.[1,2] The fetal membrane lines the intrauterine cavity (Figure 1A) and provides critical mechanical, immune, and endocrine support to protect the fetus during gestation[1,3–12] and has been shown to provide vital labor initiating signaling at term and preterm.[2,5,13–20] The function of the fetal membrane is derived from its unique makeup of multiple collagen layers,[21–23] along with fetal-derived cells that line with maternal decidua, forming the feto-maternal interface. A summary of the structure and function of the fetal membranes and the challenges researchers face studying this tissue are described below.
{"title":"Fetal membrane at the feto-maternal interface: An underappreciated and understudied intrauterine tissue.","authors":"Lauren Richardson, Ramkumar Menon","doi":"10.54844/prm.2022.0104","DOIUrl":"https://doi.org/10.54844/prm.2022.0104","url":null,"abstract":"While most intrauterine tissues are thoroughly studied for their role in pregnancy maintenance and their contribution to labor initiation, the fetal membranes (i.e., amniochorionic membranes) are primarily overlooked.[1,2] The fetal membrane lines the intrauterine cavity (Figure 1A) and provides critical mechanical, immune, and endocrine support to protect the fetus during gestation[1,3–12] and has been shown to provide vital labor initiating signaling at term and preterm.[2,5,13–20] The function of the fetal membrane is derived from its unique makeup of multiple collagen layers,[21–23] along with fetal-derived cells that line with maternal decidua, forming the feto-maternal interface. A summary of the structure and function of the fetal membranes and the challenges researchers face studying this tissue are described below.","PeriodicalId":74455,"journal":{"name":"Placenta and reproductive medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-07-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/21/3e/nihms-1870826.PMC10373051.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10260958","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Cell culture and organ explant systems have traditionally been used by scientists in the reproductive biology and perinatal medicine area to address various research questions. Although most are unrelated to human pregnancy, animal models were also extensively used to study various mechanisms associated with pregnancy and parturition. However, limitations of traditional approaches have shifted the attention to the use of organ on a chip (OOC) technology. OOC platform simulates an organ using cells, and OOCs are biomimetic microfluidic systems comprising multiple cell types from an organ that mimic the environment of a physiological organ. OOC maintains intercellular interactions and helps to recreate organ physiology as expected for utero in perinatal medicine research. This short review introduces some basic concepts of OOC, and its utility based on some published reports
{"title":"Organ-on-a-chip for perinatal biology experiments","authors":"R. Menon, Lauren S. Richardson","doi":"10.54844/prm.2022.0098","DOIUrl":"https://doi.org/10.54844/prm.2022.0098","url":null,"abstract":"Cell culture and organ explant systems have traditionally been used by scientists in the reproductive biology and perinatal medicine area to address various research questions. Although most are unrelated to human pregnancy, animal models were also extensively used to study various mechanisms associated with pregnancy and parturition. However, limitations of traditional approaches have shifted the attention to the use of organ on a chip (OOC) technology. OOC platform simulates an organ using cells, and OOCs are biomimetic microfluidic systems comprising multiple cell types from an organ that mimic the environment of a physiological organ. OOC maintains intercellular interactions and helps to recreate organ physiology as expected for utero in perinatal medicine research. This short review introduces some basic concepts of OOC, and its utility based on some published reports","PeriodicalId":74455,"journal":{"name":"Placenta and reproductive medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-07-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43678176","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
DOI: 10.54844/prm.2022.0108 The placenta, as the tree of life, is an organ of utmost importance, supporting fetal development by secreting hormones, cytokines, and other compounds and by mediating nutrient and waste exchange. Normal development and function of early placentation allows the maternal defense system to recognize and tolerate the semiallogeneic fetus that carries paternal antigens and to allow for the normal invasion of trophoblasts. Dysfunctional maternal-fetal crosstalk and deficient placentation are significantly linked to pregnancy loss and pregnancy complications, such as miscarriage,[1] intrauterine growth restriction or stillbirth,[2] and pre-eclampsia.[3]
{"title":"Placenta and Reproductive Medicine: Covering research on perinatal health","authors":"Chong Qiao, N. Zhong","doi":"10.54844/prm.2022.0108","DOIUrl":"https://doi.org/10.54844/prm.2022.0108","url":null,"abstract":"DOI: 10.54844/prm.2022.0108 The placenta, as the tree of life, is an organ of utmost importance, supporting fetal development by secreting hormones, cytokines, and other compounds and by mediating nutrient and waste exchange. Normal development and function of early placentation allows the maternal defense system to recognize and tolerate the semiallogeneic fetus that carries paternal antigens and to allow for the normal invasion of trophoblasts. Dysfunctional maternal-fetal crosstalk and deficient placentation are significantly linked to pregnancy loss and pregnancy complications, such as miscarriage,[1] intrauterine growth restriction or stillbirth,[2] and pre-eclampsia.[3]","PeriodicalId":74455,"journal":{"name":"Placenta and reproductive medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-07-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47080848","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"New hope for preventing preterm birth: The promise of vaginal nanoformulations.","authors":"Sandra E Reznik","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":74455,"journal":{"name":"Placenta and reproductive medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/ab/32/nihms-1848638.PMC9683351.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40486157","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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