Jia-po Li, Hongfei Shen, Maryam F. Abdelrahim, G. Chu, Ling Huang, Chong Qiao
Citrullinemia type 1 (CTLN1) is a rare autosomal recessive urea cycle disorder, without functional argininosuccinate synthase 1 (ASS1), mostly occurring in newborns and infants, but it has been reported as having an adult-onset in carriers of the pathogenic gene, and even more rarely, the onset of the disease is pregnancy related. Only 12 reported cases of onset during pregnancy and puerperium were reported since 1980. We herein report a case of gestational onset that resulted in patient death with a reported pathogenic mutation, c.421-2A>G, resulting in an amino acid change, splicing mutation, on exon7, in ASS1 gene, and a novel mutation, c.1046T>G, resulting in an amino acid change p.V349G, predicted by sorting intolerant from tolerant (SIFT), PolyPhen-2, Mutation Taster, Genomic Evolutionary Rate Profiling 2 (GERP++) and Rare Exome Variant Ensemble Learner (REVEL). This article provides an overview of the relationship between CTLN1 and pregnancy and discusses the possible mechanisms, clinical manifestations, and genetic characteristics of pregnancy-related onset.
{"title":"Pregnancy-related type citrullinemia type 1: A case report and literature review","authors":"Jia-po Li, Hongfei Shen, Maryam F. Abdelrahim, G. Chu, Ling Huang, Chong Qiao","doi":"10.54844/prm.2023.0339","DOIUrl":"https://doi.org/10.54844/prm.2023.0339","url":null,"abstract":"Citrullinemia type 1 (CTLN1) is a rare autosomal recessive urea cycle disorder, without functional argininosuccinate synthase 1 (ASS1), mostly occurring in newborns and infants, but it has been reported as having an adult-onset in carriers of the pathogenic gene, and even more rarely, the onset of the disease is pregnancy related. Only 12 reported cases of onset during pregnancy and puerperium were reported since 1980. We herein report a case of gestational onset that resulted in patient death with a reported pathogenic mutation, c.421-2A>G, resulting in an amino acid change, splicing mutation, on exon7, in ASS1 gene, and a novel mutation, c.1046T>G, resulting in an amino acid change p.V349G, predicted by sorting intolerant from tolerant (SIFT), PolyPhen-2, Mutation Taster, Genomic Evolutionary Rate Profiling 2 (GERP++) and Rare Exome Variant Ensemble Learner (REVEL). This article provides an overview of the relationship between CTLN1 and pregnancy and discusses the possible mechanisms, clinical manifestations, and genetic characteristics of pregnancy-related onset.\u0000","PeriodicalId":74455,"journal":{"name":"Placenta and reproductive medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47328667","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-31Epub Date: 2023-03-20DOI: 10.54844/prm.2022.0296
Nina Truong, Ramkumar Menon, Lauren Richardson
During pregnancy, the fetal membranes (i.e., amniochorionic membranes) surround the intrauterine cavity and provide mechanical, immune, and endocrine support to protect the fetus. Though they are a vital component of the intrauterine cavity, the fetal membranes are largely overlooked as an extension of the placenta, leading to a poor understanding of their role during gestation, parturition, or preterm birth. The fetal membranes are comprised of fetal cellular and stromal layers and line up with maternal decidua forming the feto-maternal interface during pregnancy. This interface plays a large role during pregnancy and the induction of term or preterm parturition (e.g., labor). Here we summarize the function of the fetal membranes focusing on their role during gestation at term, and during preterm births.
{"title":"The Role of Fetal Membranes during Gestation, at Term, and Preterm Labor.","authors":"Nina Truong, Ramkumar Menon, Lauren Richardson","doi":"10.54844/prm.2022.0296","DOIUrl":"10.54844/prm.2022.0296","url":null,"abstract":"<p><p>During pregnancy, the fetal membranes (i.e., amniochorionic membranes) surround the intrauterine cavity and provide mechanical, immune, and endocrine support to protect the fetus. Though they are a vital component of the intrauterine cavity, the fetal membranes are largely overlooked as an extension of the placenta, leading to a poor understanding of their role during gestation, parturition, or preterm birth. The fetal membranes are comprised of fetal cellular and stromal layers and line up with maternal decidua forming the feto-maternal interface during pregnancy. This interface plays a large role during pregnancy and the induction of term or preterm parturition (e.g., labor). Here we summarize the function of the fetal membranes focusing on their role during gestation at term, and during preterm births.</p>","PeriodicalId":74455,"journal":{"name":"Placenta and reproductive medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10831903/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46398979","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Kfier Kuba, Michael A Kirby, Francine Hughes, Steven M Yellon
Some 60 years ago, obstetrician and clinical researcher Edward H. Bishop first proposed a pelvic score to guide “selection of those patients most suitable for induction” of labor. [1] This original Bishop score is the summation of a numerical estimate for each of five criteria that included cervix dilation, effacement, consistency, position, and station. Notably, only multigravida women at term with prior vaginal delivery were studied, and induction of labor (IOL) methods at the time consisted of oxytocin, membrane stripping, and amniotomy. Empirical evidence by Bishop indicated that “induction may be successfully and safely performed when the pelvic score totals 9 or more. Under such circumstances, we have had no failures in induction, and the average duration of labor has been less than 4 hr” to achieve vaginal birth. IOL has since become more commonplace. Moreover, major advances in management of labor and new approaches to cervical ripening and IOL have improved maternal and newborn outcomes.[2] The simplicity and ease to implement
{"title":"Reassessing the Bishop score in clinical practice for induction of labor leading to vaginal delivery and for evaluation of cervix ripening.","authors":"Kfier Kuba, Michael A Kirby, Francine Hughes, Steven M Yellon","doi":"10.54844/prm.2023.0353","DOIUrl":"https://doi.org/10.54844/prm.2023.0353","url":null,"abstract":"Some 60 years ago, obstetrician and clinical researcher Edward H. Bishop first proposed a pelvic score to guide “selection of those patients most suitable for induction” of labor. [1] This original Bishop score is the summation of a numerical estimate for each of five criteria that included cervix dilation, effacement, consistency, position, and station. Notably, only multigravida women at term with prior vaginal delivery were studied, and induction of labor (IOL) methods at the time consisted of oxytocin, membrane stripping, and amniotomy. Empirical evidence by Bishop indicated that “induction may be successfully and safely performed when the pelvic score totals 9 or more. Under such circumstances, we have had no failures in induction, and the average duration of labor has been less than 4 hr” to achieve vaginal birth. IOL has since become more commonplace. Moreover, major advances in management of labor and new approaches to cervical ripening and IOL have improved maternal and newborn outcomes.[2] The simplicity and ease to implement","PeriodicalId":74455,"journal":{"name":"Placenta and reproductive medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/d4/94/nihms-1914374.PMC10500565.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10670429","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Zhengyan Hu, Rui Gao, Hanxiao Chen, Minqi Chen, Lang Qin
Infertility has become a worldwide issue, and many patients cannot benefit from assisted reproductive technologies (ART). The extracellular matrix (ECM) is critical in tissue organization and remodeling. The female reproductive system plays an important role in menstruation, pregnancy, and ovulation and may influence fertility. In addition, ECM has a wide variety of components, good biological properties, and extensive application experience as a biomaterial. In-depth research on the ECM in the female reproductive system and the development and application of ECM-derived materials may provide new ideas for solving infertility problems. This review aimed to summarize the regulation and changes of ECM in the uterus and ovary, and to discuss the progress of research on ECM-derived materials in reproductive tissue engineering. An extensive search in PubMed and Embase was conducted using keywords including extracellular matrix, uterus, ovary, tissue engineering, and material. We are devoted to combining research on ECM-derived materials with clinical practice and intend to provide ideas for solving clinical problems in reproductive medicine.
{"title":"Extracellular matrix and extracellular matrix-derived materials in reproductive medicine","authors":"Zhengyan Hu, Rui Gao, Hanxiao Chen, Minqi Chen, Lang Qin","doi":"10.54844/prm.2022.0142","DOIUrl":"https://doi.org/10.54844/prm.2022.0142","url":null,"abstract":"Infertility has become a worldwide issue, and many patients cannot benefit from assisted reproductive technologies (ART). The extracellular matrix (ECM) is critical in tissue organization and remodeling. The female reproductive system plays an important role in menstruation, pregnancy, and ovulation and may influence fertility. In addition, ECM has a wide variety of components, good biological properties, and extensive application experience as a biomaterial. In-depth research on the ECM in the female reproductive system and the development and application of ECM-derived materials may provide new ideas for solving infertility problems. This review aimed to summarize the regulation and changes of ECM in the uterus and ovary, and to discuss the progress of research on ECM-derived materials in reproductive tissue engineering. An extensive search in PubMed and Embase was conducted using keywords including extracellular matrix, uterus, ovary, tissue engineering, and material. We are devoted to combining research on ECM-derived materials with clinical practice and intend to provide ideas for solving clinical problems in reproductive medicine.","PeriodicalId":74455,"journal":{"name":"Placenta and reproductive medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47996285","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
li-Ying Peng, Tingxuan Yin, Weijie Zhao, Chunfang Xu, Meirong Du
A coordinated crosstalk between the maternal body and embryo is indispensable in a successful pregnancy. However, reliable models to study the potential cellular and molecular mechanisms of maternal-fetal interaction have not been established. The widely used research models including animal models and cell lines have significant limitations. Recently, the emergence and advancement of organoids have aroused attention. Endometrial organoids and trophoblast organoids which recapitulate human decidua and trophoblasts in three-dimensional cultures provide new opportunities to study the physiological or pathological processes of decidualization and implantation. Furthermore, to recapitulate precise cell-cell communication in the decidual microenvironment in vivo, the co-culture of multicellular organoids will be a potential optimal model for future investigations of crosstalk at the maternal-fetal interface. Here, we focus on the latest development and advancement of endometrial organoids and trophoblast organoids.
{"title":"Endometrial organoids and trophoblast organoids: Novel models for investigation of maternal-fetal interactions","authors":"li-Ying Peng, Tingxuan Yin, Weijie Zhao, Chunfang Xu, Meirong Du","doi":"10.54844/prm.2022.0141","DOIUrl":"https://doi.org/10.54844/prm.2022.0141","url":null,"abstract":"A coordinated crosstalk between the maternal body and embryo is indispensable in a successful pregnancy. However, reliable models to study the potential cellular and molecular mechanisms of maternal-fetal interaction have not been established. The widely used research models including animal models and cell lines have significant limitations. Recently, the emergence and advancement of organoids have aroused attention. Endometrial organoids and trophoblast organoids which recapitulate human decidua and trophoblasts in three-dimensional cultures provide new opportunities to study the physiological or pathological processes of decidualization and implantation. Furthermore, to recapitulate precise cell-cell communication in the decidual microenvironment in vivo, the co-culture of multicellular organoids will be a potential optimal model for future investigations of crosstalk at the maternal-fetal interface. Here, we focus on the latest development and advancement of endometrial organoids and trophoblast organoids.","PeriodicalId":74455,"journal":{"name":"Placenta and reproductive medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46619217","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Li-qiong Zhu, Yue-ting Huang, Fei Li, Xiaohui Ji, Yu-kun Liu, S. Fu, Shuning Zhang, Kewen Deng, Hanjie Mo, Jian-ping Tan, Jianping Zhang, Hui Chen
Objective: To investigate the incidence of subchorionic hematoma (SCH), pregnancy outcomes and health status of offspring in patients with recurrent spontaneous miscarriage (RSA) treated with intravenous immunoglobulin (IVIg). Methods: The records of 775 patients with RSA were retrospectively reviewed. RSA with SCH were all treated with IVIg. Pregnancy outcomes examined were the rates of miscarriage, stillbirth, pre-term birth, and live birth. The pregnancy complications and comorbidities examined included oligohydramnios, hypertensive disorders, gestational diabetes, premature membrane rupture, placental adhesions, placenta previa, postpartum hemorrhage, placental abruption, and low birth weight. The health status of offspring of RSA patients with SCH was followed up by telephone, record physical and neurodevelopmental performance, and diseases under 5 years old, then compare with common children. Based on the ratio of SCH volume to that of the gestational sac, SCH was divided into small (ratio < 20%), moderate (ratio = 20%–50%), and large (ratio > 50%). Statistical analysis was performed with IBM SPSS Statistics 23.0. Comparison of continuous variables was analyzed using t-test. Categorical variables were compared by using χ2 test or Fisher’s exact test. Multivariable logistic regression was used for adjusting certain confounders. Results: Of the 775 patients with RSA, 110 RSA had a SCH (incidence = 14.2%). SCH was firstly found at 8.29 (5.00–11.58) weeks pregnant. There was no statistical difference in age, number of pregnancies, parity and miscarriages between patients with and without an SCH. The incidence of SCH in in-vitro fertilization embryo transfer (IVF-ET) patients was higher than in natural pregnancy patients (27.9% vs. 13.1%, P < 0.05). RSA with SCH patients with pregnancy outcome data called Group A (n = 94), RSA without SCH patients with pregnancy outcome data called Group B (n = 556), the rates of miscarriage (17.0% vs.12.4%), stillbirth (0 vs. 0.4%), pre-term delivery (9.6% vs. 10.8%), live birth (84.7% vs. 80.9%), and pregnancy complications were not different between Group A and B. The rate of vaginal bleeding in the Group A was higher than in the Group B (P < 0.05). There was no significant difference in the birth weight, the rate of low birth weight infants, neonatal asphyxia, or neonatal pneumonia between the groups. 43 puerpera in the experimental group were willing to receive telephone follow-up, who gave birth from December 2015 to November 2016. A total of 43 live births were delivered. By March 2022, the children were 5 years and 4 months old to 6 years and 3 months old. There is no difference in the physical development compared with common children. A child was diagnosed with neuropsychological delay. The incidence rate of community acquired pneumonia (CAP) was 27.9 per 1000 person-years for children under 5 years. In patients with a SCH and vaginal bleeding, the rate of preterm birth was 16.7%. The rate of preterm b
目的:探讨静脉注射免疫球蛋白(IVIg)治疗复发性自然流产(RSA)患者的绒毛膜下血肿(SCH)发生率、妊娠结局及后代健康状况。方法:回顾性分析775例RSA患者的临床资料。RSA和SCH均用IVIg治疗。妊娠结局包括流产、死产、早产和活产的发生率。检查的妊娠并发症和合并症包括羊水过少、高血压、妊娠糖尿病、胎膜早破、胎盘粘连、前置胎盘、产后出血、胎盘早剥和低出生体重。通过电话随访RSA患儿的子代健康状况，记录5岁以下儿童的身体和神经发育表现及疾病情况，并与普通儿童进行比较。根据SCH体积与妊娠囊体积之比，将SCH分为小(比例< 20%)、中(比例= 20% ~ 50%)和大(比例> 50%)。采用IBM SPSS Statistics 23.0进行统计学分析。连续变量比较采用t检验。分类变量比较采用χ2检验或Fisher精确检验。多变量逻辑回归用于调整某些混杂因素。结果:775例RSA患者中，110例RSA合并SCH(发生率为14.2%)。妊娠8.29(5.00-11.58)周首次发现SCH。发生和未发生SCH的患者在年龄、妊娠次数、胎次、流产等方面均无统计学差异。体外受精胚胎移植(IVF-ET)患者发生SCH的发生率高于自然妊娠患者(27.9% vs. 13.1%， P < 0.05)。有妊娠结局资料的RSA合并SCH患者称为A组(n = 94)，无妊娠结局资料的RSA合并SCH患者称为B组(n = 556)，流产率(17.0% vs.12.4%)、死胎率(0 vs. 0.4%)、早产率(9.6% vs. 10.8%)、活产率(84.7% vs. 80.9%)、妊娠并发症在A组和B组之间无显著差异。A组阴道出血率高于B组(P < 0.05)。两组在出生体重、低出生体重儿发生率、新生儿窒息或新生儿肺炎方面无显著差异。实验组中愿意接受电话随访的产妇43例，均为2015年12月~ 2016年11月分娩的产妇。共有43名活产婴儿出生。到2022年3月，孩子们的年龄从5岁4个月到6岁3个月。与普通儿童相比，他们的身体发育没有什么不同。一个孩子被诊断为神经心理发育迟缓。5岁以下儿童社区获得性肺炎(CAP)发病率为27.9 / 1000人年。在伴有阴道出血的患者中，早产率为16.7%。大SCH组早产率最高(36.4%)，小SCH组早产率仅为5.7% (P < 0.05)。接受IVIg治疗的患者有轻度不良反应，如体温过低、头晕和皮疹，发生率分别为1.8%、1.8%和0.9%。结论:RSA中SCH的发生率为14.2%。经IVIg治疗的RSA伴SCH患者与未伴SCH患者妊娠结局相似，伴SCH的RSA子代与普通子代体格发育无差异，SCH对子代神经发育的影响有待扩大样本量进一步验证。RSA合并SCH的患者容易出现阴道出血和腹痛。对于有SCH合并阴道出血的RSA患者，或SCH容积比为50%的患者，即使在IVIg后，仍会导致明显较高的早产率。
{"title":"A retrospective study of pregnancy outcomes when intravenous immunoglobulin is used for the treatment of recurrent spontaneous miscarriages with subchorionic hematoma","authors":"Li-qiong Zhu, Yue-ting Huang, Fei Li, Xiaohui Ji, Yu-kun Liu, S. Fu, Shuning Zhang, Kewen Deng, Hanjie Mo, Jian-ping Tan, Jianping Zhang, Hui Chen","doi":"10.54844/prm.2022.0099","DOIUrl":"https://doi.org/10.54844/prm.2022.0099","url":null,"abstract":"Objective: To investigate the incidence of subchorionic hematoma (SCH), pregnancy outcomes and health status of offspring in patients with recurrent spontaneous miscarriage (RSA) treated with intravenous immunoglobulin (IVIg). Methods: The records of 775 patients with RSA were retrospectively reviewed. RSA with SCH were all treated with IVIg. Pregnancy outcomes examined were the rates of miscarriage, stillbirth, pre-term birth, and live birth. The pregnancy complications and comorbidities examined included oligohydramnios, hypertensive disorders, gestational diabetes, premature membrane rupture, placental adhesions, placenta previa, postpartum hemorrhage, placental abruption, and low birth weight. The health status of offspring of RSA patients with SCH was followed up by telephone, record physical and neurodevelopmental performance, and diseases under 5 years old, then compare with common children. Based on the ratio of SCH volume to that of the gestational sac, SCH was divided into small (ratio < 20%), moderate (ratio = 20%–50%), and large (ratio > 50%). Statistical analysis was performed with IBM SPSS Statistics 23.0. Comparison of continuous variables was analyzed using t-test. Categorical variables were compared by using χ2 test or Fisher’s exact test. Multivariable logistic regression was used for adjusting certain confounders. Results: Of the 775 patients with RSA, 110 RSA had a SCH (incidence = 14.2%). SCH was firstly found at 8.29 (5.00–11.58) weeks pregnant. There was no statistical difference in age, number of pregnancies, parity and miscarriages between patients with and without an SCH. The incidence of SCH in in-vitro fertilization embryo transfer (IVF-ET) patients was higher than in natural pregnancy patients (27.9% vs. 13.1%, P < 0.05). RSA with SCH patients with pregnancy outcome data called Group A (n = 94), RSA without SCH patients with pregnancy outcome data called Group B (n = 556), the rates of miscarriage (17.0% vs.12.4%), stillbirth (0 vs. 0.4%), pre-term delivery (9.6% vs. 10.8%), live birth (84.7% vs. 80.9%), and pregnancy complications were not different between Group A and B. The rate of vaginal bleeding in the Group A was higher than in the Group B (P < 0.05). There was no significant difference in the birth weight, the rate of low birth weight infants, neonatal asphyxia, or neonatal pneumonia between the groups. 43 puerpera in the experimental group were willing to receive telephone follow-up, who gave birth from December 2015 to November 2016. A total of 43 live births were delivered. By March 2022, the children were 5 years and 4 months old to 6 years and 3 months old. There is no difference in the physical development compared with common children. A child was diagnosed with neuropsychological delay. The incidence rate of community acquired pneumonia (CAP) was 27.9 per 1000 person-years for children under 5 years. In patients with a SCH and vaginal bleeding, the rate of preterm birth was 16.7%. The rate of preterm b","PeriodicalId":74455,"journal":{"name":"Placenta and reproductive medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42277707","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Zhexian Sun, Wenjie Wu, Peinan Zhao, A. Odibo, Qing Wang, Yong Wang
Background: Non-invasive in vivo diffusion-weighted magnetic resonance imaging (DWI) of the human placenta allows safe imaging and accurate characterization of the microstructure of the placenta during pregnancy. However, misalignment of different diffusion-weighted images caused by the maternal and fetal motion severely compromised the accuracy of diffusion magnetic resonance imaging (MRI) quantification. In this study, we proposed a diffusion tensor-based registration method customized to correct the image misalignment in DWI and enhance the multi-parametric imaging of human placenta microstructures. Method: We developed a novel registration method based on the diffusion tensor imaging (DTI) model and Fourier-approximated Lie Algebras for Shooting (FLASHC). We extensively tested and validated our method using simulated DWI images, which were contaminated by motion and deformation of the placenta. DWI of the entire uterus was acquired in 86 different directions with bmax = 2000 s/mm2. Our method is quantitatively evaluated using the continuous dice coefficient (cDC) and fitting residue from DTI and diffusion basis spectrum imaging (DBSI). Our method enables the application of advanced and complicated diffusion analysis models and detailed cotyledon-wise quantification of human placenta microstructural features. Result: The proposed method was proven efficient in registering simulated DWI deformed by motion, with increase mean cDC (from 0.78 to 0.93) and decrease mean fitting residue (DTI from 10.95% to 9.01%, DBSI from 8.01% to 3.07%). Similar improvements were found in registering DWI from clinical patients (cDC from 0.79 to 0.86 , DTI from 34.7 to 28.2%, DBSI from 6.5 to 2.8%.). Also, DBSI derived maps showed reasonable pattern after registration. After cotyledon-wise segmentation, region regional increased cellularity ratio was found in one patient with placental cyst and infarction. Conclusion: The proposed registration method provides a robust framework for motion correction in diffusion-weighted MR images and enabled the detailed and accurate quantification of human placenta microstructures.
{"title":"Diffusion tensor based motion correction enables multi-parametric imaging of human placenta microstructures","authors":"Zhexian Sun, Wenjie Wu, Peinan Zhao, A. Odibo, Qing Wang, Yong Wang","doi":"10.54844/prm.2022.0125","DOIUrl":"https://doi.org/10.54844/prm.2022.0125","url":null,"abstract":"Background: Non-invasive in vivo diffusion-weighted magnetic resonance imaging (DWI) of the human placenta allows safe imaging and accurate characterization of the microstructure of the placenta during pregnancy. However, misalignment of different diffusion-weighted images caused by the maternal and fetal motion severely compromised the accuracy of diffusion magnetic resonance imaging (MRI) quantification. In this study, we proposed a diffusion tensor-based registration method customized to correct the image misalignment in DWI and enhance the multi-parametric imaging of human placenta microstructures. Method: We developed a novel registration method based on the diffusion tensor imaging (DTI) model and Fourier-approximated Lie Algebras for Shooting (FLASHC). We extensively tested and validated our method using simulated DWI images, which were contaminated by motion and deformation of the placenta. DWI of the entire uterus was acquired in 86 different directions with bmax = 2000 s/mm2. Our method is quantitatively evaluated using the continuous dice coefficient (cDC) and fitting residue from DTI and diffusion basis spectrum imaging (DBSI). Our method enables the application of advanced and complicated diffusion analysis models and detailed cotyledon-wise quantification of human placenta microstructural features. Result: The proposed method was proven efficient in registering simulated DWI deformed by motion, with increase mean cDC (from 0.78 to 0.93) and decrease mean fitting residue (DTI from 10.95% to 9.01%, DBSI from 8.01% to 3.07%). Similar improvements were found in registering DWI from clinical patients (cDC from 0.79 to 0.86 , DTI from 34.7 to 28.2%, DBSI from 6.5 to 2.8%.). Also, DBSI derived maps showed reasonable pattern after registration. After cotyledon-wise segmentation, region regional increased cellularity ratio was found in one patient with placental cyst and infarction. Conclusion: The proposed registration method provides a robust framework for motion correction in diffusion-weighted MR images and enabled the detailed and accurate quantification of human placenta microstructures.","PeriodicalId":74455,"journal":{"name":"Placenta and reproductive medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-11-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46463866","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Objective: To analyze the emergent serious conditions contributing to cerebral palsy (CP) of neonates without a history of the necessity of neonatal resuscitation within 5 minutes after delivery in Japan. Methods: To examine the clinical courses regarding CP cases, we reviewed the summary reports of antenatal- and peripartum CP cases published on the home page of the Japan Obstetric Compensation System for Cerebral Palsy (JOCSC) launched in 2009. Results: Between January 2009 and February 2016, in Japan there were 51 cases analyzed as CP due to emergent serious condition of the neonates without a history of necessity of neonatal resuscitation within 5 minutes after delivery at the Japan Obstetric Compensation System for CP. The main pathological conditions described as the cause of CP were as follows: the concept of brief resolved unexplained events/apparent life-threatening event (n = 15), neonatal Group B streptococcus infection (n = 12), herpes simplex virus infection (n = 6), neonatal hypoglycemia (n = 3), and neonatal hyperkalemia (n = 3). Conclusions: Based on the current cases, we should note that neonates are very unstable, especially in the early period after delivery.
{"title":"Emergent serious condition of the neonates associated with cerebral palsy in Japan","authors":"Shunji Suzuki","doi":"10.54844/prm.2022.0084","DOIUrl":"https://doi.org/10.54844/prm.2022.0084","url":null,"abstract":"Objective: To analyze the emergent serious conditions contributing to cerebral palsy (CP) of neonates without a history of the necessity of neonatal resuscitation within 5 minutes after delivery in Japan. Methods: To examine the clinical courses regarding CP cases, we reviewed the summary reports of antenatal- and peripartum CP cases published on the home page of the Japan Obstetric Compensation System for Cerebral Palsy (JOCSC) launched in 2009. Results: Between January 2009 and February 2016, in Japan there were 51 cases analyzed as CP due to emergent serious condition of the neonates without a history of necessity of neonatal resuscitation within 5 minutes after delivery at the Japan Obstetric Compensation System for CP. The main pathological conditions described as the cause of CP were as follows: the concept of brief resolved unexplained events/apparent life-threatening event (n = 15), neonatal Group B streptococcus infection (n = 12), herpes simplex virus infection (n = 6), neonatal hypoglycemia (n = 3), and neonatal hyperkalemia (n = 3). Conclusions: Based on the current cases, we should note that neonates are very unstable, especially in the early period after delivery.","PeriodicalId":74455,"journal":{"name":"Placenta and reproductive medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42940028","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
To provide comprehensive support for women, we believe that the recognition of pregnancy as a positive opportunity to re-examine women’s health will be important. In our department, we will be continuous concerning phenomena and diseases that may occur in their life, so that women can lead the best life for each individual.[1,2] In addition to research to prepare for a safe and comfortable pregnancy and delivery, we aim to snuggle up to the whole life of women by examining not only the physical health care but also the mental health care.
{"title":"Anticoagulant therapy and psychological problem: Preparing for emerging problems associated with pregnancy and delivery","authors":"Shunji Suzuki","doi":"10.54844/prm.2022.0083","DOIUrl":"https://doi.org/10.54844/prm.2022.0083","url":null,"abstract":"To provide comprehensive support for women, we believe that the recognition of pregnancy as a positive opportunity to re-examine women’s health will be important. In our department, we will be continuous concerning phenomena and diseases that may occur in their life, so that women can lead the best life for each individual.[1,2] In addition to research to prepare for a safe and comfortable pregnancy and delivery, we aim to snuggle up to the whole life of women by examining not only the physical health care but also the mental health care.","PeriodicalId":74455,"journal":{"name":"Placenta and reproductive medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49361046","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Defined as birth before 37 completed weeks of gestation, preterm birth (PTB) accounts for the vast majority of perinatal morbidity and mortality. [1–3] Sadly, data collected by the World Health Organization indicate that the annual rate of PTB worldwide has not improved over the last several decades and is greater than 10% in most countries. [4] PTB rates are generally higher in the developing world; among industrialized nations, the United States (US) has the highest rate of PTB. [2] In the US particularly, advances in neonatology have occurred more rapidly than in the field of obstetrics, so that more and more neonates born closer and closer to the cusp of viability survive their neonatal intensive care unit stay, only to live with a constellation of medical challenges. The acute sequelae of PTB, such as respiratory distress syndrome and necrotizing enterocolitis, are replaced by lifelong respiratory, metabolic and neurologic abnormalities, including retinopathy of prematurity and cerebral palsy. [5] The personal and societal costs of PTB are enormous.
{"title":"New hope for preventing preterm birth: The promise of vaginal nanoformulations","authors":"S. Reznik","doi":"10.54844/prm.2022.0100","DOIUrl":"https://doi.org/10.54844/prm.2022.0100","url":null,"abstract":"Defined as birth before 37 completed weeks of gestation, preterm birth (PTB) accounts for the vast majority of perinatal morbidity and mortality. [1–3] Sadly, data collected by the World Health Organization indicate that the annual rate of PTB worldwide has not improved over the last several decades and is greater than 10% in most countries. [4] PTB rates are generally higher in the developing world; among industrialized nations, the United States (US) has the highest rate of PTB. [2] In the US particularly, advances in neonatology have occurred more rapidly than in the field of obstetrics, so that more and more neonates born closer and closer to the cusp of viability survive their neonatal intensive care unit stay, only to live with a constellation of medical challenges. The acute sequelae of PTB, such as respiratory distress syndrome and necrotizing enterocolitis, are replaced by lifelong respiratory, metabolic and neurologic abnormalities, including retinopathy of prematurity and cerebral palsy. [5] The personal and societal costs of PTB are enormous.","PeriodicalId":74455,"journal":{"name":"Placenta and reproductive medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-07-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43002290","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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