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Organizational Behavior Management: a supplement and alternative to traditional areas of work in the analysis of behavior. 组织行为管理:行为分析传统工作领域的补充和替代。
Pub Date : 2023-12-01 Epub Date: 2024-03-12 DOI: 10.5114/ppn.2023.135981
Paweł Bakalarz

Purpose: The purpose of this paper is to present to a community of behavior specialists, an overview of the subdiscipline of Organizational Behavior Management (OBM) in three aspects. First, OBM is a sub-branch of the larger field of Applied Behavior Analysis. It also has two other aspects: it can complement the traditional set of skills useful to behavior analysts or be one of the alternative careers for them.

Views: Behavior specialists predominantly, and especially in Poland, teach populations with special needs. Whether this is in special education, social assistance or select areas of health care, with young children with autism or adults with intellectual disability, this is where most behavior analysts work. At the same time, they often need to skillfully cooperate in teams, sometimes manage them or instruct people other than those with whom they are usually in contact, such as new team members, parents, and other specialists. OBM can be seen as a supplementary background that answers these needs. It is also a possible alternative career path, with a distinct client base and flagship journal, as well as specific procedures in behavior analysis, experts in the field and specialisms.

Conclusions: Different client populations, variations in instruction techniques and knowledge of response generalization all point to that conclusion that traditional behavior analysts might be largely at a disadvantage in the area covered by OBM: that of a management and team leading and training typically developing clients. Behavior analysts require a background in OBM, otherwise they might "reinvent the OBM wheel" or - which is worse - apply their experiences one-to-one with special populations and bring with them harmful assumptions.

目的:本文旨在从三个方面向行为专家介绍组织行为管理(OBM)这一分支学科的概况。首先,组织行为管理(OBM)是应用行为分析(Applied Behavior Analysis)这一大领域的一个分支。它还有另外两个方面:它可以补充行为分析师的传统技能,也可以成为行为分析师的替代职业之一:行为专家主要教授有特殊需求的人群,在波兰尤其如此。无论是在特殊教育、社会援助或特定的医疗保健领域,还是在自闭症幼儿或智障成人中,这都是大多数行为分析师的工作领域。同时,他们经常需要在团队中熟练地合作,有时还需要管理团队,或指导那些他们通常接触不到的人,如团队中的新成员、家长和其他专家。开放式管理可以被视为满足这些需求的补充背景。它也是一条可能的替代职业道路,有独特的客户群和旗舰期刊,以及行为分析的特定程序、该领域的专家和专业:不同的客户群体、不同的指导技术和反应泛化知识都表明,传统的行为分析师在开放式行为管理所涵盖的领域可能会处于劣势:即在领导和培训典型发展型客户的管理和团队方面。行为分析师需要有开放式管理的背景,否则他们可能会 "重新发明开放式管理的轮子",或者--更糟糕的是--将他们的经验一对一地应用于特殊人群,并带来有害的假设。
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引用次数: 0
Activities of daily living training in a stroke patient based on applied behaviour analysis. 基于应用行为分析的中风患者日常生活活动训练。
Pub Date : 2023-12-01 Epub Date: 2024-01-19 DOI: 10.5114/ppn.2023.134447
Martyna Gwiazdowska

Purpose: Description of the behavioural therapy of a patient after a subarachnoid haemorrhage from a ruptured aneurysm of the anterior communicating artery with an intracerebral haemorrhage, after aneurysm embolisation and left craniotomy, and after an ischemic cerebral stroke.

Case description: The author presents behavioural therapy techniques used in patient rehabilitation in all areas requiring improvement in the daily functioning of a disabled person. The course of selected therapeutic interventions is analysed and the effects of the interventions are assessed. The presented case is an example of successful behavioural therapeutic intervention that led to changes compared to the initial functional state of the organism. Thanks to the use of behavioural techniques, independent multi- profile patient functioning was achieved. Given the limited availability of health services, the focus on the therapy on evidence-based teaching makes them intrinsic to the patient's success.

Comment: The presented phases of therapy fully reflect the effective modification of behaviour patterns in a person after a subarachnoid haemorrhage from a ruptured aneurysm in the anterior communicating artery with an intracerebral haemorrhage, after aneurysm embolisation and left craniotomy, and after an ischemic cerebral stroke. The outcome of the applied behaviour approach seems to be significant enough to encourage the further development of the therapy for stroke patients regardless of the type of neurological disorders, functional difficulties, and age.

目的:描述一名患者在前交通动脉瘤破裂蛛网膜下腔出血并伴有脑内出血、动脉瘤栓塞和左侧开颅手术后以及缺血性脑卒中后的行为治疗:作者介绍了用于患者康复的行为治疗技术,涉及需要改善残疾人日常功能的所有领域。作者分析了选定治疗干预的过程,并评估了干预的效果。所介绍的病例是一个成功的行为治疗干预案例,与最初的机体功能状态相比,它带来了变化。由于使用了行为技术,病人的功能实现了独立多元。鉴于医疗服务的有限性,将治疗重点放在循证教学上使其成为患者成功的内在因素:评论:所介绍的治疗阶段充分反映了在前交通动脉动脉瘤破裂导致蛛网膜下腔出血并伴有脑内出血、动脉瘤栓塞和左侧开颅手术后以及缺血性脑卒中后患者行为模式的有效改变。应用行为疗法的结果似乎非常显著,足以鼓励进一步发展针对中风患者的疗法,而不论其神经系统疾病的类型、功能障碍和年龄。
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引用次数: 0
Potential applications of Schema Therapy in the treatment of adolescents with anorexia nervosa: a theoretical analysis. 图式疗法在治疗神经性厌食症青少年中的潜在应用:理论分析。
Pub Date : 2023-12-01 Epub Date: 2024-02-19 DOI: 10.5114/ppn.2023.135530
Angelika Kleszczewska-Albińska

Purpose: The main purpose of the article is to present basic theoretical assumptions on Schema Therapy and its hypothetical application among adolescents suffering with anorexia nervosa.

Views: Anorexia nervosa is a very deadly mental disease, more frequently suffered by females than males, with the mean age of onset at approximately 14-15. Studies underline the relatively poor effectiveness of currently applied treatment methods and the need for new approaches that could be recommended for adolescent patients suffering with this disease. The results of studies conducted to date lead to the conclusion that Schema Therapy is a promising approach for this group. It is a transdiagnostic method of work that compiles elements known in other therapeutic approaches, aiming at an increase in the individual's awareness of their feelings and emotional needs, applied both in adolescent and adult groups of patients. Since the symptoms of eating disorders observed in adolescents are strongly connected with family systems it seems reasonable to use treatment techniques that rigorously address the unmet needs and rejected emotions of the individual.

Conclusions: Based on the data published so far it might be hypothesized that the techniques characteristic for Schema Therapy (e.g. imagery rescripting, chairwork, limited reparenting) could be eligible for use with adolescent patients with anorexia nervosa.They address unmet needs, rejected emotions, and early maladaptive schemas that are very frequent in patients with AN. Since the analysis presented provides only hypotheses and the discussion of theoretical aspects, empirical research in this area is needed.

目的:文章的主要目的是介绍模式疗法的基本理论假设及其在患有神经性厌食症的青少年中的假设应用:神经性厌食症是一种非常致命的精神疾病,女性患者多于男性,平均发病年龄约为 14-15 岁。研究强调,目前采用的治疗方法效果相对较差,因此需要向患有这种疾病的青少年患者推荐新的治疗方法。迄今为止的研究结果表明,"模式疗法 "是一种很有前途的治疗方法。这是一种跨诊断的工作方法,综合了其他治疗方法中的已知要素,旨在提高个人对自身感受和情感需求的认识,同时适用于青少年和成年患者群体。由于在青少年中观察到的饮食失调症状与家庭系统密切相关,因此似乎有理由采用严格解决个人未满足的需求和被拒绝的情感的治疗技术:根据迄今为止公布的数据,我们可以假设,模式疗法(如意象重写、椅子工作、有限的再养育)所特有的技术有资格用于青少年厌食症患者,这些技术可以解决厌食症患者经常出现的未满足的需求、被拒绝的情绪和早期适应不良模式。由于本文的分析只提供了假设和理论方面的讨论,因此需要在这一领域开展实证研究。
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引用次数: 0
Increasing water intake and walking with a self-management intervention using negative and positive reinforcement. 采用负强化和正强化的自我管理干预措施,增加水的摄入量和步行次数。
Pub Date : 2023-12-01 Epub Date: 2024-01-18 DOI: 10.5114/ppn.2023.134454
Rafał Gebauer, Paweł Ostaszewski, Monika Suchowierska-Stephany, Paul W Stephany

Introduction: This study compared the effectiveness of different types of reinforcement (positive, negative, and a combination of both) in a self-management intervention program designed to increase water intake and walking.

Methods: Four university students participated in a self-management program to increase water intake and walking. Multiple baseline design across behaviors that included baseline (A) condition, positive reinforcement (B) condition, negative reinforcement (C) condition, and combination of both (B + C), was introduced. The participants received $2 every day they met the criteria during the positive reinforcement condition and no consequence if they failed to meet the criteria. In the negative reinforcement condition, $2 was subtracted for each day that the participant did not meet the criteria from the total amount of money available to the participant during that phase of the study. During the condition with positive and negative reinforcement, the participants received $2 every day they met the criteria. However, $2 was subtracted from the total for every day they did not meet the criteria.

Results: There was a clear increase from baseline to the first intervention phase across all the behaviors and participants, and the increase was maintained throughout the study. There were no differences in the effectiveness of different types of reinforcement applied in self-management intervention programs.

Conclusions: The study did show that implementing a relatively low-cost reinforcement contingency increased both exercise and water drinking. The results suggest that there are no consistent differences in the effectiveness of positive or negative reinforcement contingencies in self-management intervention.

简介:本研究比较了在旨在增加水摄入量和步行的自我管理干预计划中不同类型强化(积极、消极和两者相结合)的效果:本研究比较了在一项旨在增加水摄入量和步行次数的自我管理干预计划中不同类型强化(积极、消极以及两者的结合)的效果:方法:四名大学生参加了一项旨在增加水摄入量和步行次数的自我管理计划。在行为上采用多重基线设计,包括基线(A)条件、正强化(B)条件、负强化(C)条件和两者结合(B + C)条件。在正强化条件下,参与者每天达到标准可获得 2 美元,如果没有达到标准则没有任何后果。在负强化条件下,参与者每天未达到标准,就会从该研究阶段参与者可获得的总金额中减去 2 美元。在正强化和负强化条件下,参与者每天都能获得 2 美元。结果:结果:从基线到第一个干预阶段,所有行为和参与者的行为量都有明显增加,并且在整个研究过程中都保持了这种增加。在自我管理干预计划中,不同类型的强化效果没有差异:研究结果表明,实施成本相对较低的强化应急措施可以增加运动量和饮水量。结果表明,在自我管理干预中,正强化或负强化的效果并无一致的差异。
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引用次数: 0
From direct contingencies to derived relations: the ever-developing nature of theory and practice in behavior analysis. 从直接或然到衍生关系:行为分析理论与实践的不断发展。
Pub Date : 2023-12-01 Epub Date: 2024-02-19 DOI: 10.5114/ppn.2023.135529
Krystyna Pomorska, Paweł Ostaszewski

Purpose: To illustrate the processes of development within the behavioral theory and the corresponding expansion of the areas in which it is applied, especially the advancement (conceptual developments) of the functional analysis of language inspired by Relational Frame Theory (RFT) research.

Views: Classical and operant conditioning are well-established behavioral learning processes, discovered and described at the beginning of the twentieth century. They provide the tools for analyzing, establishing and modifying the functions of stimuli and responses of the organisms through manipulation of the environment. Although B. F. Skinner provided grounds for the functional analysis of complex behaviors such as language, it was not until the beginning of the twenty-first century that RFT was introduced. From this moment behavior analysts could use behavioral principles to explain how stimulus functions may change without direct learning. The practical application of the growing knowledge about Arbitrarily Applicable Relational Responding (AARR), a basic generalized operant described within RFT, allows us to analyze, explain and change behaviors that had hitherto been beyond the scope of behavioral therapy. The continued growth and development of behavior theory and practice holds the promise for an expansion of its application to new areas and populations in need. One such development is the functional analysis of verbal behavior e.g., relational frames, ROE (relating-orienting-evoking).

Conclusions: It seems useful to add advancements proposed by RFT to the behavioral toolbox with which we could effectively describe, explain and change behavior with precision, scope and depth.

目的:说明行为理论的发展过程及其应用领域的相应扩展,尤其是受关系框架理论(RFT)研究启发的语言功能分析的进步(概念发展):经典条件反射和操作性条件反射是二十世纪初发现并描述的成熟的行为学习过程。它们提供了通过操纵环境来分析、建立和修改生物体的刺激和反应功能的工具。虽然 B. F. 斯金纳(B. F. Skinner)为复杂行为(如语言)的功能分析提供了依据,但直到二十一世纪初,RFT 才被引入。从此,行为分析学家可以利用行为学原理来解释刺激功能是如何在没有直接学习的情况下发生变化的。任意适用关系反应(Arbitrarily Applicable Relational Responding,AARR)是 RFT 中描述的一种基本的通用操作行为,不断增长的相关知识的实际应用使我们能够分析、解释和改变迄今为止行为疗法无法解决的行为问题。行为理论和实践的持续增长和发展,为将其应用扩展到新的领域和有需要的人群带来了希望。其中一项发展就是对言语行为的功能分析,例如关系框架、ROE(关系定向诱发):在行为学工具箱中加入 RFT 提出的先进方法似乎很有帮助,我们可以利用这些方法有效地描述、解释和改变行为,并使其具有精确性、广度和深度。
{"title":"From direct contingencies to derived relations: the ever-developing nature of theory and practice in behavior analysis.","authors":"Krystyna Pomorska, Paweł Ostaszewski","doi":"10.5114/ppn.2023.135529","DOIUrl":"10.5114/ppn.2023.135529","url":null,"abstract":"<p><strong>Purpose: </strong>To illustrate the processes of development within the behavioral theory and the corresponding expansion of the areas in which it is applied, especially the advancement (conceptual developments) of the functional analysis of language inspired by Relational Frame Theory (RFT) research.</p><p><strong>Views: </strong>Classical and operant conditioning are well-established behavioral learning processes, discovered and described at the beginning of the twentieth century. They provide the tools for analyzing, establishing and modifying the functions of stimuli and responses of the organisms through manipulation of the environment. Although B. F. Skinner provided grounds for the functional analysis of complex behaviors such as language, it was not until the beginning of the twenty-first century that RFT was introduced. From this moment behavior analysts could use behavioral principles to explain how stimulus functions may change without direct learning. The practical application of the growing knowledge about Arbitrarily Applicable Relational Responding (AARR), a basic generalized operant described within RFT, allows us to analyze, explain and change behaviors that had hitherto been beyond the scope of behavioral therapy. The continued growth and development of behavior theory and practice holds the promise for an expansion of its application to new areas and populations in need. One such development is the functional analysis of verbal behavior e.g., relational frames, ROE (relating-orienting-evoking).</p><p><strong>Conclusions: </strong>It seems useful to add advancements proposed by RFT to the behavioral toolbox with which we could effectively describe, explain and change behavior with precision, scope and depth.</p>","PeriodicalId":74481,"journal":{"name":"Postepy psychiatrii neurologii","volume":"32 4","pages":"200-208"},"PeriodicalIF":0.0,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10976621/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140338005","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Between neurodiversity and therapy: the importance of making conscious and responsible choices in supporting individuals on the autism spectrum. 在神经多样性与治疗之间:在支持自闭症谱系中的个体时做出有意识和负责任的选择的重要性。
Pub Date : 2023-12-01 Epub Date: 2024-02-21 DOI: 10.5114/ppn.2023.135596
Przemysław Bąbel, Paweł Ostaszewski
{"title":"Between neurodiversity and therapy: the importance of making conscious and responsible choices in supporting individuals on the autism spectrum.","authors":"Przemysław Bąbel, Paweł Ostaszewski","doi":"10.5114/ppn.2023.135596","DOIUrl":"10.5114/ppn.2023.135596","url":null,"abstract":"","PeriodicalId":74481,"journal":{"name":"Postepy psychiatrii neurologii","volume":"32 4","pages":"175-180"},"PeriodicalIF":0.0,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10976613/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140338004","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Neutropenia in a schizophrenia patient following combined lurasidone and paliperidone therapy: a case report. 鲁拉西酮和帕利哌酮联合治疗后精神分裂症患者中性粒细胞减少:一例报告。
Pub Date : 2023-09-01 Epub Date: 2023-11-17 DOI: 10.5114/ppn.2023.132474
Zuzanna Mielczarek, Beata Trędzbor, Katarzyna Piekarska-Bugiel, Krzysztof Krysta

Purpose: Lurasidon is a relatively new, second-generation antipsychotic drug with an interesting receptor profile. It is considered to be safe and has a low risk of side effects. It is a substance with a multi-receptor mechanism of action: it mainly blocks dopaminergic D2 and serotonergic 5-HT2A receptors. According to the Summary of Product Characteristics, the adverse reaction of neutropenia was too rare to enable the estimation of its frequency.

Case description: A case of 39-year-old patient is presented in the article, diagnosed with paranoid schizophrenia, who developed neutropenia as a result of treatment with lurasidone. After the discontinuation of lurasidone and recommended supplementation, the blood test results gradually improved and finally reached the normal range.

Comment: This case report shows the need for regular monitoring of blood cell parameters in patients treated with second-generation antipsychotics, as there is a risk of neutrocytopenia or even agranulocitosis.

目的:Lurasidon是一种相对较新的第二代抗精神病药物,具有有趣的受体谱。它被认为是安全的,副作用的风险很低。它是一种具有多受体作用机制的物质:主要阻断多巴胺能D2和血清素能5-HT2A受体。根据产品特性总结,中性粒细胞减少症的不良反应非常罕见,无法估计其发生频率。病例描述:一个39岁的病例是在文章中提出的,诊断为偏执型精神分裂症,谁开发中性粒细胞减少的结果与鲁拉西酮治疗。停用鲁拉西酮并推荐补充后,血检结果逐渐改善,最终达到正常范围。评论:本病例报告显示,接受第二代抗精神病药物治疗的患者需要定期监测血细胞参数,因为存在中性细胞减少症甚至粒细胞增多症的风险。
{"title":"Neutropenia in a schizophrenia patient following combined lurasidone and paliperidone therapy: a case report.","authors":"Zuzanna Mielczarek, Beata Trędzbor, Katarzyna Piekarska-Bugiel, Krzysztof Krysta","doi":"10.5114/ppn.2023.132474","DOIUrl":"10.5114/ppn.2023.132474","url":null,"abstract":"<p><strong>Purpose: </strong>Lurasidon is a relatively new, second-generation antipsychotic drug with an interesting receptor profile. It is considered to be safe and has a low risk of side effects. It is a substance with a multi-receptor mechanism of action: it mainly blocks dopaminergic D2 and serotonergic 5-HT2A receptors. According to the Summary of Product Characteristics, the adverse reaction of neutropenia was too rare to enable the estimation of its frequency.</p><p><strong>Case description: </strong>A case of 39-year-old patient is presented in the article, diagnosed with paranoid schizophrenia, who developed neutropenia as a result of treatment with lurasidone. After the discontinuation of lurasidone and recommended supplementation, the blood test results gradually improved and finally reached the normal range.</p><p><strong>Comment: </strong>This case report shows the need for regular monitoring of blood cell parameters in patients treated with second-generation antipsychotics, as there is a risk of neutrocytopenia or even agranulocitosis.</p>","PeriodicalId":74481,"journal":{"name":"Postepy psychiatrii neurologii","volume":"32 3","pages":"152-155"},"PeriodicalIF":0.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10683055/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138464950","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Combining samidorphan with olanzapine to mitigate weight gain as a side effect in schizophrenia treatment. samidorphan联合奥氮平减轻精神分裂症治疗中体重增加的副作用。
Pub Date : 2023-09-01 Epub Date: 2023-11-17 DOI: 10.5114/ppn.2023.132493
Weronika B Grywińska, Aleksandra Głowacka
Purpose This article analyzes clinical trials that provide evidence for the positive effects of using samidorphan to mitigate undesirable weight gain in patients diagnosed with schizophrenia who are undergoing treatment with olanzapine. Views Weight gain is a prevalent and problematic side effect of antipsychotic drug therapy, particularly in patients with schizophrenia. To address this issue, extensive research is being conducted to explore new drug therapies that can effectively counteract psychotic symptoms while minimizing the occurrence of unwanted side effects. One promising approach involves the addition of weight-loss substances to existing medications. Studies have indicated that opioid receptor antagonists, such as samidorphan, have the potential to facilitate weight loss. Consequently, a novel therapy combining samidorphan and olanzapine has been developed and is discussed in detail in this article. Conclusions The combination of samidorphan and olanzapine has demonstrated its ability to effectively reduce weight gain in patients with schizophrenia, without compromising the drug’s primary function of alleviating psychotic symptoms. Moreover, the inclusion of samidorphan in the treatment regimen may contribute to a lower risk of cardiovascular events, though it is worth noting that it could also lead to an increase in digestive side effects. Despite this potential drawback, the introduction of this innovative therapy represents a significant advancement in the management of obesity among individuals with schizophrenia.
目的:本文分析临床试验,为使用萨米多芬减轻正在接受奥氮平治疗的精神分裂症患者体重增加的积极作用提供证据。观点:体重增加是抗精神病药物治疗的一个普遍且有问题的副作用,特别是在精神分裂症患者中。为了解决这个问题,广泛的研究正在进行,以探索新的药物疗法,可以有效地抵消精神病症状,同时尽量减少不必要的副作用的发生。一种很有希望的方法是在现有药物中加入减肥物质。研究表明,阿片受体拮抗剂,如samidorphan,具有促进减肥的潜力。因此,一种新的治疗方法结合萨米多芬和奥氮平已被开发,并在本文中详细讨论。结论:萨米多芬与奥氮平联合用药可有效减轻精神分裂症患者体重增加,且不影响药物缓解精神病症状的主要功能。此外,在治疗方案中加入samidorphan可能有助于降低心血管事件的风险,尽管值得注意的是,它也可能导致消化副作用的增加。尽管存在潜在的缺陷,但这种创新疗法的引入代表了精神分裂症患者肥胖管理的重大进步。
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引用次数: 0
Course of therapy in patients with active relapsing-remitting multiple sclerosis despite first-line treatment. 活动性复发-缓解型多发性硬化症患者的治疗过程,尽管一线治疗。
Pub Date : 2023-06-01 DOI: 10.5114/ppn.2023.129048
Halina Bartosik-Psujek, Monika Adamczyk-Sowa, Alina Kułakowska, Joanna Głażewska, Anna Smaga, Waldemar Brola

Purpose: Treatment of patients with relapsing-remitting multiple sclerosis (RRMS) in Poland begins with first-line therapy; however, the treatment often fails. The aim of this study was to investigate the course of first-line treatment in patients who, despite experiencing an active course of the disease, did not receive more efficacious treatment due to the existing criteria in the drug program.

Methods: The study included 139 patients from 45 treatment centers. Medical data concerning the course of treatment were collected with the use of specific forms.

Results: The most frequently used drugs were β-interferons, and treatment was initiated with these drugs in most cases; however, administration of dimethyl fumarate was also common. The median treatment duration was 30.9 months, with the longest treatment duration observed for β-interferons. The most common reason for therapy switching or termination was treatment failure.

Conclusions: First-line therapy in the studied population was based mainly on β-interferons and dimethyl fumarate. For most medications, the discontinuation of therapy or drug switching were very common and the main reason was total or partial treatment failure. These observations suggest the need for earlier implementation of more effective treatment, based on drugs with high efficacy, in the study population.

目的:波兰复发-缓解型多发性硬化症(RRMS)患者的治疗始于一线治疗;然而,这种治疗经常失败。本研究的目的是调查一线治疗的过程,尽管经历了一个活跃的病程,但由于药物计划的现有标准,没有得到更有效的治疗。方法:本研究纳入了来自45个治疗中心的139例患者。使用特定表格收集了有关治疗过程的医疗数据。结果:使用频率最高的药物为β-干扰素,且以β-干扰素为主;然而,施用富马酸二甲酯也很常见。中位治疗时间为30.9个月,其中β-干扰素治疗时间最长。切换或终止治疗的最常见原因是治疗失败。结论:研究人群的一线治疗主要基于β-干扰素和富马酸二甲酯。对于大多数药物,停药或换药是很常见的,主要原因是完全或部分治疗失败。这些观察结果表明,需要在研究人群中尽早实施基于高效药物的更有效治疗。
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引用次数: 0
Are children with attention-deficit/ hyperactivity disorder (ADHD) more likely to develop celiac disease? A prospective study. 患有注意力缺陷/多动障碍(ADHD)的儿童更容易患乳糜泻吗?一项前瞻性研究。
Pub Date : 2023-06-01 DOI: 10.5114/ppn.2023.127573
Mohammad Hasan Mohammadi, Mehran Hesaraki

Purpose: The aim of this study was to evaluate whether the prevalence of celiac among attention-deficit/hyperactivity disorder (ADHD) patients is higher than among the normal population.

Methods: The present study was a prospective one investigating ADHD children referred to the Neurology Clinic and Pediatric Ward at Amir Al-Momenin Hospital of Zabol (Sistan and Baluchestan, Iran) in 2019 after their parents' signing of a consent form. All patients underwent Biocard™ Celiac and serology tests. Data were analyzed with SPSS version 21 software.

Results: Of all 76 ADHD children undergoing a serum IgA antibodies concentration test, 58 (76%) were male and 18 (23.7%) were female. The mean age of the children was 6.9 ± 2.4, ranging from 2 years to 12 years. The diagnosis of IgA immunodeficiency was rejected for all children based on total serum IgA antibody results. The overall mean anti-tissue transglutaminase (TTG) level was 6.8 ± 5.3 U/ml, ranging from 0.2 to 37 U/ml. There was no significant difference regarding TTG levels between boys and girls (5.1 vs. 6.0) U/ml. Based on the anti-TTG level results, no celiac case was found among the ADHD patients.

Conclusions: There is as yet no evidence suggesting a link between celiac disease and ADHD. Thus, routine celiac disease screening when evaluating for ADHD (and is not recommended). However, the possibility of untreated celiac disease predisposing an individual to ADHD-like behaviors should be considered. Hence, physicians are recommended to evaluate a broad range of physical symptoms, in addition to typical neuropsychiatric symptoms, when evaluating ADHD patients.

目的:本研究的目的是评估乳糜泻在注意缺陷/多动障碍(ADHD)患者中的患病率是否高于正常人群。方法:本研究是一项前瞻性研究,调查在父母签署同意书后,于2019年转介到Zabol(伊朗锡斯坦和俾路支斯坦)Amir Al-Momenin医院神经病学诊所和儿科病房的ADHD儿童。所有患者均接受了Biocard™乳糜泻和血清学检测。数据分析采用SPSS 21版软件。结果:接受血清IgA抗体浓度检测的76例ADHD患儿中,男性58例(76%),女性18例(23.7%)。患儿平均年龄6.9±2.4岁,年龄从2岁到12岁不等。根据血清总IgA抗体结果,拒绝所有儿童的IgA免疫缺陷诊断。总体平均抗组织转谷氨酰胺酶(TTG)水平为6.8±5.3 U/ml,范围为0.2 ~ 37 U/ml。男孩和女孩之间TTG水平无显著差异(5.1 vs. 6.0) U/ml。根据抗ttg水平结果,ADHD患者中未发现乳糜泻病例。结论:目前还没有证据表明乳糜泻和多动症之间存在联系。因此,在评估ADHD时,常规的乳糜泻筛查(不推荐)。然而,应该考虑到未经治疗的乳糜泻使个体容易产生adhd样行为的可能性。因此,在评估ADHD患者时,除了典型的神经精神症状外,建议医生评估广泛的身体症状。
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引用次数: 0
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Postepy psychiatrii neurologii
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