{"title":"The use of 18FDG PET/CT for radiotherapy treatment planning in non-small cell lung cancer: a mini review","authors":"E. Gkika, A. Grosu, U. Nestle","doi":"10.21037/pcm-22-38","DOIUrl":"https://doi.org/10.21037/pcm-22-38","url":null,"abstract":"","PeriodicalId":74487,"journal":{"name":"Precision cancer medicine","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49259416","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
W. Phillips, A. Awan, B. Lo, A. Redway, G. Nicholas
{"title":"The role of concurrent amplification of PD-L1, PD-L2 and JAK2 in metastatic lung adenocarcinoma as a biomarker of immune checkpoint inhibitor response: a case report","authors":"W. Phillips, A. Awan, B. Lo, A. Redway, G. Nicholas","doi":"10.21037/pcm-22-39","DOIUrl":"https://doi.org/10.21037/pcm-22-39","url":null,"abstract":"","PeriodicalId":74487,"journal":{"name":"Precision cancer medicine","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41352040","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
L. Brunetti, V. Santo, M. Russano, Alessio Cortellini, A. Galletti, F. Citarella, G. D. Di Fazio, Alessia Vendittelli, Giulia La Cava, B. Vincenzi, G. Tonini, D. Santini
{"title":"Emerging drivers in non-small cell lung cancer, is there a role for immunotherapy?—a narrative review","authors":"L. Brunetti, V. Santo, M. Russano, Alessio Cortellini, A. Galletti, F. Citarella, G. D. Di Fazio, Alessia Vendittelli, Giulia La Cava, B. Vincenzi, G. Tonini, D. Santini","doi":"10.21037/pcm-22-33","DOIUrl":"https://doi.org/10.21037/pcm-22-33","url":null,"abstract":"","PeriodicalId":74487,"journal":{"name":"Precision cancer medicine","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43519346","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
M. Albanesi, R. Didonna, N. Chaoul, Federica Mazzone, Marco Zurlo, F. Iacovelli, F. Monitillo, Flavio Rimmaudo, M. Tucci, M. Cives, C. Porta, V. Procacci
{"title":"A challenge in emergency department: a case report of oxaliplatin-induced Kounis syndrome","authors":"M. Albanesi, R. Didonna, N. Chaoul, Federica Mazzone, Marco Zurlo, F. Iacovelli, F. Monitillo, Flavio Rimmaudo, M. Tucci, M. Cives, C. Porta, V. Procacci","doi":"10.21037/pcm-22-51","DOIUrl":"https://doi.org/10.21037/pcm-22-51","url":null,"abstract":"","PeriodicalId":74487,"journal":{"name":"Precision cancer medicine","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48180318","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
C. Zirafa, G. Romano, E. Sicolo, A. Castaldi, F. Davini, F. Melfi
{"title":"Lung cancer surgery in women: focus on gender-related outcomes—a narrative review","authors":"C. Zirafa, G. Romano, E. Sicolo, A. Castaldi, F. Davini, F. Melfi","doi":"10.21037/pcm-22-23","DOIUrl":"https://doi.org/10.21037/pcm-22-23","url":null,"abstract":"","PeriodicalId":74487,"journal":{"name":"Precision cancer medicine","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45349030","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"First-line ALK inhibitors in treatment-naive advanced ALK rearranged non-small cell lung cancer: systematic review and network meta-analysis","authors":"A. Tan, S. Tan, M. Ang, D. S. Tan","doi":"10.21037/pcm-22-54","DOIUrl":"https://doi.org/10.21037/pcm-22-54","url":null,"abstract":"","PeriodicalId":74487,"journal":{"name":"Precision cancer medicine","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45416396","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Alejandro Olivares-Hernández, J. Miramontes-González, Juan Luis García Hernández, E. del Barco Morillo, E. Fonseca-Sánchez
{"title":"Biomarkers for immunotherapy in non-small cell lung cancer: a current and future reality","authors":"Alejandro Olivares-Hernández, J. Miramontes-González, Juan Luis García Hernández, E. del Barco Morillo, E. Fonseca-Sánchez","doi":"10.21037/pcm-22-68","DOIUrl":"https://doi.org/10.21037/pcm-22-68","url":null,"abstract":"","PeriodicalId":74487,"journal":{"name":"Precision cancer medicine","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47145516","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The cerebral vasculature represents a major component of the brain, constituting 25–30% of the total brain volume (1) and providing essential support to the cells of the nervous system. The blood vessels penetrating or leaving the brain parenchyma present unique anatomical properties, including the presence of a fluid-filled perivascular compartment, known as perivascular space (PVS) or Virchow-Robin space. PVS physiological function is still not completely understood, but is thought to be related to the cerebrospinal/interstitial fluid circulation and the clearance of cerebral waste products. In fact, in recent years, PVS have been described as main pathways in clearance system models of the brain (2), and numerous studies reported the association between PVS alterations and several neurological diseases. As PVS follow the course of the penetrating blood vessels and have a tubular shape, they appear on magnetic resonance imaging (MRI) as lines or dots, based on the orientation of the PVS with respect to the image acquisition plane (parallel or perpendicular, respectively), and have a signal intensity similar to the cerebrospinal fluid (i.e., hypointense on T1-weighted images and hyperintense on T2-weighted images). PVS cross-sectional diameter is usually less than 2 mm and on MRI they are most commonly seen in the centrum semiovale and basal ganglia (3,4). Thanks to the improved resolution and signal-to-noise ratio, modern MRI scanners and sequences currently allow to visualize PVS in practically all individuals, including healthy young adults
{"title":"Neuroimaging aspects and clinical significance of giant perivascular spaces in the brain.","authors":"Giuseppe Barisano","doi":"10.21037/pcm-22-27","DOIUrl":"https://doi.org/10.21037/pcm-22-27","url":null,"abstract":"The cerebral vasculature represents a major component of the brain, constituting 25–30% of the total brain volume (1) and providing essential support to the cells of the nervous system. The blood vessels penetrating or leaving the brain parenchyma present unique anatomical properties, including the presence of a fluid-filled perivascular compartment, known as perivascular space (PVS) or Virchow-Robin space. PVS physiological function is still not completely understood, but is thought to be related to the cerebrospinal/interstitial fluid circulation and the clearance of cerebral waste products. In fact, in recent years, PVS have been described as main pathways in clearance system models of the brain (2), and numerous studies reported the association between PVS alterations and several neurological diseases. As PVS follow the course of the penetrating blood vessels and have a tubular shape, they appear on magnetic resonance imaging (MRI) as lines or dots, based on the orientation of the PVS with respect to the image acquisition plane (parallel or perpendicular, respectively), and have a signal intensity similar to the cerebrospinal fluid (i.e., hypointense on T1-weighted images and hyperintense on T2-weighted images). PVS cross-sectional diameter is usually less than 2 mm and on MRI they are most commonly seen in the centrum semiovale and basal ganglia (3,4). Thanks to the improved resolution and signal-to-noise ratio, modern MRI scanners and sequences currently allow to visualize PVS in practically all individuals, including healthy young adults","PeriodicalId":74487,"journal":{"name":"Precision cancer medicine","volume":"5 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/2b/4b/nihms-1828488.PMC9817033.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9078379","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Chinese expert consensus recommendations for management of bone health in female patients with early breast cancer (2022 edition)","authors":"","doi":"10.21037/pcm-22-57","DOIUrl":"https://doi.org/10.21037/pcm-22-57","url":null,"abstract":"","PeriodicalId":74487,"journal":{"name":"Precision cancer medicine","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44045946","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Prospective and single-blinded evaluation of the multi-cancer Carcimun-test","authors":"A. Salat, W. Voigt, Berthold von und zu Zwerger","doi":"10.21037/pcm-21-35","DOIUrl":"https://doi.org/10.21037/pcm-21-35","url":null,"abstract":"","PeriodicalId":74487,"journal":{"name":"Precision cancer medicine","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48942302","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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