Pub Date : 2021-01-01DOI: 10.1007/978-3-030-84087-7_9
B. Jasani, R. Huss, C. Taylor
{"title":"Analytical Phase: Principles for Immunohistochemistry (IHC)","authors":"B. Jasani, R. Huss, C. Taylor","doi":"10.1007/978-3-030-84087-7_9","DOIUrl":"https://doi.org/10.1007/978-3-030-84087-7_9","url":null,"abstract":"","PeriodicalId":74487,"journal":{"name":"Precision cancer medicine","volume":"16 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"50981374","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-01-01DOI: 10.1007/978-3-030-84087-7_17
B. Jasani, R. Huss, C. Taylor
{"title":"Role of Pathologist in Precision Molecular and Digital Image Analyses","authors":"B. Jasani, R. Huss, C. Taylor","doi":"10.1007/978-3-030-84087-7_17","DOIUrl":"https://doi.org/10.1007/978-3-030-84087-7_17","url":null,"abstract":"","PeriodicalId":74487,"journal":{"name":"Precision cancer medicine","volume":"118 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"50981447","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Lung cancer in women","authors":"E. Baldini","doi":"10.21037/pcm-22-32","DOIUrl":"https://doi.org/10.21037/pcm-22-32","url":null,"abstract":"","PeriodicalId":74487,"journal":{"name":"Precision cancer medicine","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44171323","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
H. Oi, K. Yoh, S. Matsumoto, H. Izumi, Y. Shibata, T. Sakai, K. Nosaki, Y. Zenke, K. Goto
{"title":"KRAS G12V mutation as an acquired resistance mechanism after treatment with dabrafenib and trametinib in non-small cell lung cancer harbouring the BRAF V600E mutation: a case report","authors":"H. Oi, K. Yoh, S. Matsumoto, H. Izumi, Y. Shibata, T. Sakai, K. Nosaki, Y. Zenke, K. Goto","doi":"10.21037/pcm-21-55","DOIUrl":"https://doi.org/10.21037/pcm-21-55","url":null,"abstract":"","PeriodicalId":74487,"journal":{"name":"Precision cancer medicine","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43750034","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Oncogene-addicted non-small-cell lung cancer in women: a narrative review of the importance of gender-related differences in treatment outcome","authors":"C. Tibaldi, I. Stasi, E. Baldini","doi":"10.21037/pcm-21-31","DOIUrl":"https://doi.org/10.21037/pcm-21-31","url":null,"abstract":"","PeriodicalId":74487,"journal":{"name":"Precision cancer medicine","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43290769","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Squeezed into defection?—nuclear displacement by steatosis activates yes-associated protein (YAP) linked to oncogenic pathways in hepatocytes","authors":"G. Baffy","doi":"10.21037/pcm-21-21","DOIUrl":"https://doi.org/10.21037/pcm-21-21","url":null,"abstract":"","PeriodicalId":74487,"journal":{"name":"Precision cancer medicine","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41426535","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Utility of intraparenchymal blood patch testing following CT- guided lung biopsy","authors":"K. Syed, B. Benn, J. Kurman","doi":"10.21037/pcm-22-62","DOIUrl":"https://doi.org/10.21037/pcm-22-62","url":null,"abstract":"","PeriodicalId":74487,"journal":{"name":"Precision cancer medicine","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41726540","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
National University Cancer Institute, Singapore, Singapore; Novi High School, Novi, MI, USA Contributions: (I) Conception and design: TY Chan, B Vellayappan; (II) Administrative support: All authors; (III) Provision of study materials or patients: TY Chan, B Vellayappan; (IV) Collection and assembly of data: TY Chan, B Vellayappan; (V) Data analysis and interpretation: TY Chan, B Vellayappan; (VI) Manuscript writing: All authors; (VII) Final approval of manuscript: All authors. Correspondence to: Balamurugan Vellayappan. 1E Kent Ridge Road, Level 7 Tower Block, Singapore 119228, Singapore. Email: bala_vellayappan@nuhs.edu.sg.
新加坡国立大学癌症研究所，新加坡;(1)概念与设计:TY Chan, B Vellayappan;行政支助:所有作者;(III)提供研究资料或患者:TY Chan, B Vellayappan;(四)资料收集及汇编:TY Chan, B Vellayappan;(V)数据分析和解释:TY Chan, B Vellayappan;(六)稿件撰写:全体作者;(七)稿件最终审定:全体作者。寄信人:Balamurugan Vellayappan，新加坡肯特岭路1E, 7楼，新加坡119228。电子邮件:bala_vellayappan@nuhs.edu.sg。
{"title":"Wielding a double-edged sword in head and neck cancers—diagnosis, risk factors and mitigation strategies of radiation-induced head and neck sarcomas: a narrative review","authors":"T. Chan, Venkatesh Alagappan, B. Vellayappan","doi":"10.21037/pcm-21-30","DOIUrl":"https://doi.org/10.21037/pcm-21-30","url":null,"abstract":"National University Cancer Institute, Singapore, Singapore; Novi High School, Novi, MI, USA Contributions: (I) Conception and design: TY Chan, B Vellayappan; (II) Administrative support: All authors; (III) Provision of study materials or patients: TY Chan, B Vellayappan; (IV) Collection and assembly of data: TY Chan, B Vellayappan; (V) Data analysis and interpretation: TY Chan, B Vellayappan; (VI) Manuscript writing: All authors; (VII) Final approval of manuscript: All authors. Correspondence to: Balamurugan Vellayappan. 1E Kent Ridge Road, Level 7 Tower Block, Singapore 119228, Singapore. Email: bala_vellayappan@nuhs.edu.sg.","PeriodicalId":74487,"journal":{"name":"Precision cancer medicine","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47713245","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Zezhou Wang, Changming Zhou, Xiaoshuang Feng, M. Mo, Jie Shen, Ying Zheng
{"title":"Comparison of cancer incidence and mortality between China and the United States","authors":"Zezhou Wang, Changming Zhou, Xiaoshuang Feng, M. Mo, Jie Shen, Ying Zheng","doi":"10.21037/pcm-21-25","DOIUrl":"https://doi.org/10.21037/pcm-21-25","url":null,"abstract":"","PeriodicalId":74487,"journal":{"name":"Precision cancer medicine","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43560316","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
M. McKay, H. Zadeh, Carolyn Sanderson, Thomas A McKay, Aaron Chindewere
: Whole brain radiotherapy (WBRT) has been used for some decades in the treatment of metastatic cancer to the brain. It modestly improves overall survival of brain metastasis patients and in some randomised studies has been shown to prevent neurological deterioration and distant in-brain failure rates. WBRT can however, be associated with adverse quality-of-life and neurocognitive defects. Since the hippocampus has a major role in short term memory and cognitive function, hippocampal-avoidance WBRT (HA-WBRT) has become a more prevalent WBRT technique in recent years. It does not seem to be associated with increased hippocampal failures in magnetic resonance imaging-screened patients. We present the case of a 64-year-old male with metastatic malignant melanoma to the brain, who had multiple brain metastases including bilateral hippocampal metastases. We treated him with partial HA-WBRT, namely, by including in the high dose volume the hippocampal-associated metastases along with the rest of the brain, avoiding high dose to the remainder of the normal hippocampi, in an attempt to maximise his neurocognitive function. For the right hippocampal avoidance structure, the D100% was 10 Gy, maximum 18.4 Gy, while for the left hippocampal avoidance structure, the D100% was 8.45 Gy, maximum 18.1 Gy. The planning target volume (PTV) received 28.9 Gy, with <2% receiving >31 Gy. We prioritised minimising hot spots in the PTV because of the patient’s previous stereotactic radiosurgery (SRS) treatment (adjacent to the brainstem).
{"title":"Partial hippocampal sparing whole brain radiotherapy in a patient with bilateral malignant melanoma metastases to the hippocampus: a case report","authors":"M. McKay, H. Zadeh, Carolyn Sanderson, Thomas A McKay, Aaron Chindewere","doi":"10.21037/pcm-21-23","DOIUrl":"https://doi.org/10.21037/pcm-21-23","url":null,"abstract":": Whole brain radiotherapy (WBRT) has been used for some decades in the treatment of metastatic cancer to the brain. It modestly improves overall survival of brain metastasis patients and in some randomised studies has been shown to prevent neurological deterioration and distant in-brain failure rates. WBRT can however, be associated with adverse quality-of-life and neurocognitive defects. Since the hippocampus has a major role in short term memory and cognitive function, hippocampal-avoidance WBRT (HA-WBRT) has become a more prevalent WBRT technique in recent years. It does not seem to be associated with increased hippocampal failures in magnetic resonance imaging-screened patients. We present the case of a 64-year-old male with metastatic malignant melanoma to the brain, who had multiple brain metastases including bilateral hippocampal metastases. We treated him with partial HA-WBRT, namely, by including in the high dose volume the hippocampal-associated metastases along with the rest of the brain, avoiding high dose to the remainder of the normal hippocampi, in an attempt to maximise his neurocognitive function. For the right hippocampal avoidance structure, the D100% was 10 Gy, maximum 18.4 Gy, while for the left hippocampal avoidance structure, the D100% was 8.45 Gy, maximum 18.1 Gy. The planning target volume (PTV) received 28.9 Gy, with <2% receiving >31 Gy. We prioritised minimising hot spots in the PTV because of the patient’s previous stereotactic radiosurgery (SRS) treatment (adjacent to the brainstem).","PeriodicalId":74487,"journal":{"name":"Precision cancer medicine","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42240652","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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