{"title":"Squeezed into defection?—nuclear displacement by steatosis activates yes-associated protein (YAP) linked to oncogenic pathways in hepatocytes","authors":"G. Baffy","doi":"10.21037/pcm-21-21","DOIUrl":"https://doi.org/10.21037/pcm-21-21","url":null,"abstract":"","PeriodicalId":74487,"journal":{"name":"Precision cancer medicine","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41426535","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Oncogene-addicted non-small-cell lung cancer in women: a narrative review of the importance of gender-related differences in treatment outcome","authors":"C. Tibaldi, I. Stasi, E. Baldini","doi":"10.21037/pcm-21-31","DOIUrl":"https://doi.org/10.21037/pcm-21-31","url":null,"abstract":"","PeriodicalId":74487,"journal":{"name":"Precision cancer medicine","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43290769","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Utility of intraparenchymal blood patch testing following CT- guided lung biopsy","authors":"K. Syed, B. Benn, J. Kurman","doi":"10.21037/pcm-22-62","DOIUrl":"https://doi.org/10.21037/pcm-22-62","url":null,"abstract":"","PeriodicalId":74487,"journal":{"name":"Precision cancer medicine","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41726540","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-01-01DOI: 10.1007/978-3-030-84087-7_12
B. Jasani, R. Huss, C. Taylor
{"title":"Post-Analytic Phase: Interpretation, Scoring and Reporting of Biopsy Results","authors":"B. Jasani, R. Huss, C. Taylor","doi":"10.1007/978-3-030-84087-7_12","DOIUrl":"https://doi.org/10.1007/978-3-030-84087-7_12","url":null,"abstract":"","PeriodicalId":74487,"journal":{"name":"Precision cancer medicine","volume":"51 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"50981219","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-01-01DOI: 10.1007/978-3-030-84087-7_9
B. Jasani, R. Huss, C. Taylor
{"title":"Analytical Phase: Principles for Immunohistochemistry (IHC)","authors":"B. Jasani, R. Huss, C. Taylor","doi":"10.1007/978-3-030-84087-7_9","DOIUrl":"https://doi.org/10.1007/978-3-030-84087-7_9","url":null,"abstract":"","PeriodicalId":74487,"journal":{"name":"Precision cancer medicine","volume":"16 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"50981374","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-01-01DOI: 10.1007/978-3-030-84087-7_17
B. Jasani, R. Huss, C. Taylor
{"title":"Role of Pathologist in Precision Molecular and Digital Image Analyses","authors":"B. Jasani, R. Huss, C. Taylor","doi":"10.1007/978-3-030-84087-7_17","DOIUrl":"https://doi.org/10.1007/978-3-030-84087-7_17","url":null,"abstract":"","PeriodicalId":74487,"journal":{"name":"Precision cancer medicine","volume":"118 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"50981447","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-01-01DOI: 10.1007/978-3-030-84087-7_2
B. Jasani, R. Huss, C. Taylor
{"title":"The Advent of Biomarker Testing","authors":"B. Jasani, R. Huss, C. Taylor","doi":"10.1007/978-3-030-84087-7_2","DOIUrl":"https://doi.org/10.1007/978-3-030-84087-7_2","url":null,"abstract":"","PeriodicalId":74487,"journal":{"name":"Precision cancer medicine","volume":"36 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"50981585","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-01-01DOI: 10.1007/978-3-030-84087-7_3
B. Jasani, R. Huss, C. Taylor
{"title":"The Practical Challenges for Pathology: Multiple Rapidly Evolving Methods","authors":"B. Jasani, R. Huss, C. Taylor","doi":"10.1007/978-3-030-84087-7_3","DOIUrl":"https://doi.org/10.1007/978-3-030-84087-7_3","url":null,"abstract":"","PeriodicalId":74487,"journal":{"name":"Precision cancer medicine","volume":"20 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"50981661","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Zezhou Wang, Changming Zhou, Xiaoshuang Feng, M. Mo, Jie Shen, Ying Zheng
{"title":"Comparison of cancer incidence and mortality between China and the United States","authors":"Zezhou Wang, Changming Zhou, Xiaoshuang Feng, M. Mo, Jie Shen, Ying Zheng","doi":"10.21037/pcm-21-25","DOIUrl":"https://doi.org/10.21037/pcm-21-25","url":null,"abstract":"","PeriodicalId":74487,"journal":{"name":"Precision cancer medicine","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43560316","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
M. McKay, H. Zadeh, Carolyn Sanderson, Thomas A McKay, Aaron Chindewere
: Whole brain radiotherapy (WBRT) has been used for some decades in the treatment of metastatic cancer to the brain. It modestly improves overall survival of brain metastasis patients and in some randomised studies has been shown to prevent neurological deterioration and distant in-brain failure rates. WBRT can however, be associated with adverse quality-of-life and neurocognitive defects. Since the hippocampus has a major role in short term memory and cognitive function, hippocampal-avoidance WBRT (HA-WBRT) has become a more prevalent WBRT technique in recent years. It does not seem to be associated with increased hippocampal failures in magnetic resonance imaging-screened patients. We present the case of a 64-year-old male with metastatic malignant melanoma to the brain, who had multiple brain metastases including bilateral hippocampal metastases. We treated him with partial HA-WBRT, namely, by including in the high dose volume the hippocampal-associated metastases along with the rest of the brain, avoiding high dose to the remainder of the normal hippocampi, in an attempt to maximise his neurocognitive function. For the right hippocampal avoidance structure, the D100% was 10 Gy, maximum 18.4 Gy, while for the left hippocampal avoidance structure, the D100% was 8.45 Gy, maximum 18.1 Gy. The planning target volume (PTV) received 28.9 Gy, with <2% receiving >31 Gy. We prioritised minimising hot spots in the PTV because of the patient’s previous stereotactic radiosurgery (SRS) treatment (adjacent to the brainstem).
{"title":"Partial hippocampal sparing whole brain radiotherapy in a patient with bilateral malignant melanoma metastases to the hippocampus: a case report","authors":"M. McKay, H. Zadeh, Carolyn Sanderson, Thomas A McKay, Aaron Chindewere","doi":"10.21037/pcm-21-23","DOIUrl":"https://doi.org/10.21037/pcm-21-23","url":null,"abstract":": Whole brain radiotherapy (WBRT) has been used for some decades in the treatment of metastatic cancer to the brain. It modestly improves overall survival of brain metastasis patients and in some randomised studies has been shown to prevent neurological deterioration and distant in-brain failure rates. WBRT can however, be associated with adverse quality-of-life and neurocognitive defects. Since the hippocampus has a major role in short term memory and cognitive function, hippocampal-avoidance WBRT (HA-WBRT) has become a more prevalent WBRT technique in recent years. It does not seem to be associated with increased hippocampal failures in magnetic resonance imaging-screened patients. We present the case of a 64-year-old male with metastatic malignant melanoma to the brain, who had multiple brain metastases including bilateral hippocampal metastases. We treated him with partial HA-WBRT, namely, by including in the high dose volume the hippocampal-associated metastases along with the rest of the brain, avoiding high dose to the remainder of the normal hippocampi, in an attempt to maximise his neurocognitive function. For the right hippocampal avoidance structure, the D100% was 10 Gy, maximum 18.4 Gy, while for the left hippocampal avoidance structure, the D100% was 8.45 Gy, maximum 18.1 Gy. The planning target volume (PTV) received 28.9 Gy, with <2% receiving >31 Gy. We prioritised minimising hot spots in the PTV because of the patient’s previous stereotactic radiosurgery (SRS) treatment (adjacent to the brainstem).","PeriodicalId":74487,"journal":{"name":"Precision cancer medicine","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42240652","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
京公网安备 11010802042870号
京ICP备2023020795号-1
扫码关注我们
求助内容：
应助结果提醒方式：