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Chronic pain–mental health comorbidity and excess prevalence of health risk behaviours: a cross-sectional study 慢性疼痛-心理健康合并症与健康风险行为的超常发生率:一项横断面研究
Pub Date : 2024-04-08 DOI: 10.1017/s1463423624000070
Sophie Lumley, Dahai Yu, Ross Wilkie, Kelvin P. Jordan, George Peat
Background: Chronic musculoskeletal pain and anxiety/depression are significant public health problems. We hypothesised that adults with both conditions constitute a group at especially high risk of future cardiovascular health outcomes. Aim: To determine whether having comorbid chronic musculoskeletal pain and anxiety/depression is associated with the excess prevalence of selected known cardiovascular health risk behaviours. Method: A cross-sectional survey of adults aged 35+ years randomly sampled from 26 GP practice registers in West Midlands, England. Respondents were classified into four groups based on self-reported presence/absence of chronic musculoskeletal pain (pain present on most days for six months) and anxiety or depression (Hospital Anxiety and Depression Score 11+). Standardised binomial models were used to estimate standardised prevalence ratios and prevalence differences between the four groups in self-reported obesity, tobacco smoking, physical inactivity, and unhealthy alcohol consumption after controlling for age, sex, ethnicity, deprivation, employment status and educational attainment. The excess prevalence of each risk factor in the group with chronic musculoskeletal pain–anxiety/depression comorbidity was estimated. Findings: Totally, 14 519 respondents were included, of whom 1329 (9%) reported comorbid chronic musculoskeletal pain–anxiety/depression, 3612 (25%) chronic musculoskeletal pain only, 964 (7%) anxiety or depression only, and 8614 (59%) neither. Those with comorbid chronic musculoskeletal pain–anxiety/depression had the highest crude prevalence of obesity (41%), smoking (16%) and physical inactivity (83%) but the lowest for unhealthy alcohol consumption (18%). After controlling for covariates, the standardised prevalence ratios and differences for the comorbid group compared with those with neither chronic musculoskeletal pain nor anxiety/depression were as follows: current smoking [1.86 (95% CI 1.58, 2.18); 6.8%], obesity [1.93 (1.76, 2.10); 18.9%], physical inactivity [1.21 (1.17, 1.24); 14.3%] and unhealthy alcohol consumption [0.81 (0.71, 0.92); –5.0%]. The standardised prevalences of smoking and obesity in the comorbid group exceeded those expected from simple additive interaction.
背景:慢性肌肉骨骼疼痛和焦虑/抑郁是严重的公共健康问题。我们假设,患有这两种疾病的成年人是未来心血管健康风险特别高的群体。目的:确定合并慢性肌肉骨骼疼痛和焦虑/抑郁是否与某些已知心血管健康风险行为的超常发生率有关。调查方法从英国西米德兰兹郡的 26 个全科医生诊所登记册中随机抽样,对 35 岁以上的成年人进行横断面调查。根据受访者自我报告的有/无慢性肌肉骨骼疼痛(疼痛在大多数情况下持续 6 个月)和焦虑或抑郁(医院焦虑和抑郁评分 11 分以上)情况,将受访者分为四组。在控制了年龄、性别、种族、贫困程度、就业状况和受教育程度之后,使用标准化二叉模型估算了四个组别在自我报告的肥胖、吸烟、缺乏运动和不健康饮酒方面的标准化患病率比和患病率差异。对慢性肌肉骨骼疼痛-焦虑/抑郁合并症群体中各风险因素的超常发生率进行了估算。研究结果共纳入了 14 519 名受访者,其中 1329 人(9%)报告了慢性肌肉骨骼疼痛-焦虑/抑郁并发症,3612 人(25%)仅报告了慢性肌肉骨骼疼痛,964 人(7%)仅报告了焦虑或抑郁,8614 人(59%)两者均未报告。合并慢性肌肉骨骼疼痛-焦虑/抑郁的人群中,肥胖(41%)、吸烟(16%)和缺乏运动(83%)的粗发病率最高,但不健康饮酒的粗发病率最低(18%)。在控制协变量后,与既无慢性肌肉骨骼疼痛又无焦虑/抑郁的人群相比,合并症人群的标准化患病率比率和差异如下:目前吸烟 [1.86(95% CI 1.58,2.18);6.8%]、肥胖[1.93(1.76,2.10);18.9%]、缺乏运动[1.21(1.17,1.24);14.3%]和不健康饮酒[0.81(0.71,0.92);-5.0%]。合并症组中吸烟和肥胖的标准化患病率超过了简单相加作用的预期。
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引用次数: 0
Unmet and unperceived needs for type 2 diabetes self-management among slum dwellers in Iran: a cross-sectional study. 伊朗贫民窟居民对 2 型糖尿病自我管理的未满足和未感知需求:一项横断面研究。
Pub Date : 2024-03-14 DOI: 10.1017/S1463423624000045
Fawzieh Ghammari, Habib Jalilian, Masumeh Gholizadeh

Aim: This study aimed to identify unmet and unperceived needs for T2D self-management among those residing in Tabriz slums, Iran, in 2022.

Background: Type 2 diabetes (T2D) and its complications are more common among slum dwellers. T2D is a lifelong disease that requires continuous care. By contrast, slum dwellers are less likely to adhere to standard health care.

Methods: This study is cross-sectional. We included 400 patients using a systematic random sampling method. Unmet and unperceived needs were assessed through a researcher-made questionnaire. The questionnaire was developed based on Iran's Package of Essential Non-Communicable Diseases (IraPEN) instructions and an expert panel. Data were analyzed using SPSS version 22.

Findings: Need for more healthcare cost coverage by insurance organizations (85.5%), financial support to provide medicine (68%), free and accessible sports equipment in the area (48.5%), continuous access to blood sugar test instruments (47.8%), know how to test blood sugar and interpret the results (47.7%), more communication with healthcare providers (42.3%), and detailed education from health professionals (41.2%) were the most common unmet needs. The least perceived need was to know how to care for feet (16%).

目的:本研究旨在确定 2022 年居住在伊朗大不里士贫民窟的人在 2 型糖尿病自我管理方面未得到满足和未意识到的需求:背景:2 型糖尿病(T2D)及其并发症在贫民窟居民中更为常见。2 型糖尿病是一种终身疾病,需要持续护理。相比之下,贫民窟居民不太可能坚持接受标准的医疗保健:本研究为横断面研究。方法:本研究为横断面研究,采用系统随机抽样方法纳入 400 名患者。通过研究人员自制的问卷对未满足和未感知的需求进行了评估。该问卷是根据伊朗基本非传染性疾病一揽子方案(IraPEN)的说明和专家小组的意见编制的。数据使用 SPSS 22.0 版进行分析:未满足的需求中最常见的是需要保险机构提供更多的医疗费用保障(85.5%)、提供药品的财政支持(68%)、在该地区免费提供运动器材(48.5%)、持续提供血糖检测仪器(47.8%)、知道如何检测血糖和解释结果(47.7%)、与医疗服务提供者进行更多的沟通(42.3%)以及医疗专业人员提供详细的教育(41.2%)。认为最少的需求是知道如何护理双脚(16%)。
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引用次数: 0
Long-term catheter management in the community: a population-based analysis of user characteristics, service utilisation and costs in England. 社区长期导管管理:基于人口的英格兰用户特征、服务利用率和成本分析。
Pub Date : 2024-03-07 DOI: 10.1017/S1463423624000021
Heather Gage, Peter Williams, Miriam Avery, Catherine Murphy, Mandy Fader

Background: Long-term urinary catheters are problematic and burdensome for patients, carers and health services. Nursing practice to improve the management of long-term urinary catheters has been held back by a lack of evidence to support policy and practice. Little is known about who uses a catheter long term and the resources and costs needed for their management. Understanding these costs will help to target innovations to improve care. There have been no substantial innovations to urinary catheters or their management recently and no publications to characterise users and costs.

Aim: To describe long-term catheter users and explore catheter-related service use and costs in England.

Methods: Descriptive information on the characteristics of catheter users and their use of services was obtained from: General Practice records (n = 607), district nursing records (n = 303), questionnaires to patients (n = 333) and triangulated, 2009-2012. Annual service costs (British pounds 2011) were computed.

Findings: Most catheter users (59.6%) were men, nearly three-quarters (71.2%) were over 70 years and 60.8% used a urethral catheter. Women tended to be younger than men and more likely to use a suprapubic catheter. The services used most frequently over 12 months were general practitioner (by 63.1%) and out of hours services (43.0%); 15.5% accessed Accident and Emergency services for urgent catheter-related care. Hospital use accounted for nearly half (48.9%) of total health service costs (mainly due to inpatient stays by 13.6% of participants); catheter supplies/medications were next most costly (25.7%). Half of all costs were accounted for by 14.2% of users. The median annual cost of services used was £6.38, IQR: £344-£1324; district nursing services added approximately a further £200 per annum.

Conclusions: Finding better ways to reduce catheter problems (e.g. blockage, infection) that cause unplanned visits, urgent or hospital care should be a priority to improve quality of life for long-term catheter users and reduce health service expenditure.

背景:长期导尿对患者、护理人员和医疗服务机构来说都是问题和负担。由于缺乏支持政策和实践的证据,改善长期导尿管管理的护理实践一直受到阻碍。人们对哪些人长期使用导尿管以及管理导尿管所需的资源和成本知之甚少。了解这些成本将有助于有针对性地进行创新,以改善护理。最近在导尿管或其管理方面没有实质性的创新,也没有出版物对使用者和成本进行描述。目的:描述导尿管的长期使用者,探讨英格兰导尿管相关服务的使用情况和成本:有关导尿管使用者特征及其服务使用情况的描述性信息来自:2009-2012 年全科医生记录(n = 607)、地区护理记录(n = 303)、患者问卷调查(n = 333)和三角测量。计算了每年的服务成本(2011 年英镑):大多数导尿管使用者(59.6%)为男性,近四分之三(71.2%)的人年龄超过 70 岁,60.8% 的人使用尿道导尿管。女性往往比男性年轻,更有可能使用耻骨上导尿管。在 12 个月中,最常使用的服务是全科医生(63.1%)和非工作时间服务(43.0%);15.5% 的人因导尿管相关的紧急护理而使用急诊服务。住院费用占医疗服务总费用的近一半(48.9%)(主要是由于 13.6% 的参与者住院所致);其次是导管耗材/药物费用(25.7%)。14.2% 的使用者承担了所有费用的一半。所使用服务的年成本中位数为 6.38 英镑,IQR:344-1324 英镑;地区护理服务每年增加约 200 英镑:寻找更好的方法来减少导管问题(如堵塞、感染)导致的计划外就诊、紧急护理或医院护理,应成为改善长期导管使用者生活质量和减少医疗服务支出的优先事项。
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引用次数: 0
Primary care practice-based interventions and their effect on participation in population-based cancer screening programs: a systematic narrative review. 以基层医疗实践为基础的干预措施及其对参与人群癌症筛查计划的影响:系统性叙述综述。
Pub Date : 2024-02-12 DOI: 10.1017/S1463423623000713
Ebony J Verbunt, Grace Newman, Nicola S Creagh, Kristi M Milley, Jon D Emery, Margaret A Kelaher, Nicole M Rankin, Claire E Nightingale

Aim: To provide a systematic synthesis of primary care practice-based interventions and their effect on participation in population-based cancer screening programs.

Background: Globally, population-based cancer screening programs (bowel, breast, and cervical) have sub-optimal participation rates. Primary healthcare workers (PHCWs) have an important role in facilitating a patient's decision to screen; however, barriers exist to their engagement. It remains unclear how to best optimize the role of PHCWs to increase screening participation.

Methods: A comprehensive search was conducted from January 2010 until November 2023 in the following databases: Medline (OVID), EMBASE, and CINAHL. Data extraction, quality assessment, and synthesis were conducted. Studies were separated by whether they assessed the effect of a single-component or multi-component intervention and study type.

Findings: Forty-nine studies were identified, of which 36 originated from the USA. Fifteen studies were investigations of single-component interventions, and 34 studies were of multi-component interventions. Interventions with a positive effect on screening participation were predominantly multi-component, and most included combinations of audit and feedback, provider reminders, practice-facilitated assessment and improvement, and patient education across all screening programs. Regarding bowel screening, provision of screening kits at point-of-care was an effective strategy to increase participation. Taking a 'whole-of-practice approach' and identifying a 'practice champion' were found to be contextual factors of effective interventions.The findings suggest that complex interventions comprised of practitioner-focused and patient-focused components are required to increase cancer screening participation in primary care settings. This study provides novel understanding as to what components and contextual factors should be included in primary care practice-based interventions.

目的:对基于初级保健实践的干预措施及其对参与人群癌症筛查计划的影响进行系统综述:背景:在全球范围内,基于人群的癌症筛查计划(肠癌、乳腺癌和宫颈癌)的参与率并不理想。初级卫生保健工作者(PHCWs)在促进患者做出筛查决定方面发挥着重要作用;然而,他们的参与却存在障碍。目前仍不清楚如何最好地优化初级保健工作者的作用以提高筛查参与率:从 2010 年 1 月到 2023 年 11 月,我们在以下数据库中进行了全面搜索:Medline(OVID)、EMBASE 和 CINAHL。进行了数据提取、质量评估和综合。根据研究是否评估了单组分或多组分干预措施的效果以及研究类型对研究进行了分类:共发现 49 项研究,其中 36 项来自美国。其中 15 项研究是对单组分干预措施的调查,34 项研究是对多组分干预措施的调查。对筛查参与率有积极影响的干预措施主要由多部分组成,其中大部分包括审计和反馈、提供者提醒、实践促进评估和改进以及所有筛查项目中的患者教育。关于肠道筛查,在医疗点提供筛查工具包是提高参与率的有效策略。研究结果表明,要想提高初级医疗机构中癌症筛查的参与率,就必须采取由医生和患者共同参与的综合干预措施。这项研究为我们提供了新的认识,即以实践为基础的初级保健干预措施应包括哪些内容和背景因素。
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引用次数: 0
Exploring public health nurses' acceptability of clinical assessment tools in a Norwegian child health centre. 探讨挪威一家儿童保健中心的公共卫生护士对临床评估工具的接受程度。
Pub Date : 2024-02-12 DOI: 10.1017/S146342362400001X
Elisabeth Ovanger Barrett, Hilde Laholt, Geir Fagerjord Lorem, Catharina Elisabeth Arfwedson Wang

Background: Infants' symptoms of mental struggle are often diffuse and undifferentiated, and health services do not identify many infants at risk of poor development. However, primary health care is advantageous for early identification, given there are frequent consultations during the infant's first two years. Health policy encourages using evidence-based screening but use varies in primary health care. The Alarm Distress Baby Scale (ADBB) is an assessment tool targeting social withdrawal in infants 2-24 months of age.

Aim: To explore contextual factors related to public health nurses' (PHNs) acceptability of clinical assessment tools in a Norwegian child health centre.

Methods: Prior to an upcoming ADBB training, we used focus group discussions with PHNs to explore their views on their professional role and practice and how this concurs with using assessment tools.

Findings: Thematic analysis resulted in the following themes: (1) A Role requiring Supporting the Parents and Safeguarding the Infant; (2) The Challenge of Interpreting Infant Expressions; and (3) Organisational Preconditions for Accepting New Methods.

Conclusion: Our findings show that PHNs regard assessment tools as an aid to detect infants at risk, but that systematic use of such tools can hinder their ability to be flexible, egalitarian, and resource-focused. We also find that acceptability of assessment tools requires a system for continuous training and a well-established referral routine.

背景:婴儿的精神挣扎症状往往是分散的、无差别的,医疗服务机构无法识别出许多有发育不良风险的婴儿。然而,初级医疗保健在婴儿最初的两年中经常会有咨询,因此有利于早期识别。卫生政策鼓励使用循证筛查,但在初级卫生保健中的使用情况各不相同。警报困扰婴儿量表(ADBB)是一种针对2-24个月婴儿社交退缩的评估工具。目的:探讨挪威一家儿童健康中心的公共卫生护士(PHNs)对临床评估工具接受度的相关背景因素:在即将举行的ADBB培训之前,我们与公共卫生护士进行了焦点小组讨论,探讨他们对自己的专业角色和实践的看法,以及这与使用评估工具之间的关系:专题分析得出以下主题:(1)需要支持父母和保护婴儿的角色;(2)解读婴儿表达的挑战;以及(3)接受新方法的组织前提:我们的研究结果表明,公共卫生护士将评估工具视为发现高危婴儿的辅助工具,但系统地使用这些工具会妨碍他们灵活、平等和以资源为中心的能力。我们还发现,评估工具的可接受性需要持续的培训系统和完善的转诊程序。
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引用次数: 0
Influencing factors of knowledge proficiency of general practitioners in rural China for esophageal cancer prevention and treatment: a cross-sectional study. 中国农村全科医生食管癌防治知识熟练程度的影响因素:一项横断面研究。
Pub Date : 2024-02-12 DOI: 10.1017/S1463423623000701
Jinjia Zhang, Huadong Wu, Rongying Wang, Min Zhang

Background: This study aims to investigate the knowledge of rural general practitioners (GPs) in esophageal cancer (EC) prevention and treatment in China and analyze relevant influencing factors, so as to improve the ability of rural GPs in EC prevention and treatment.

Methods: This cross-sectional study was conducted from November 5, 2021, to November 20, 2021. A self-designed questionnaire was used to conduct an online survey. Multivariable logistic regression models were used to identify the influencing factors of knowledge proficiency of GPs in rural China for EC prevention and treatment.

Results: This study included 348 participants from 12 rural areas in Hebei Province. The mean accuracy rate on all question items was 42.3% ± 10.67%. Sex (OR = 2.870, 95% CI: 1.519-5.423), educational level (OR = 3.256, 95% CI: 1.135-9.339), and comprehension of clinical practice guidelines for EC (OR = 4.305, 95% CI: 2.023-9.161) were significant predictors for GPs' knowledge proficiency of EC prevention and treatment (P < 0.05).

Conclusions: The study indicated that knowledge proficiency of rural GPs of EC prevention and control still awaits to be improved. Sex, educational level, and comprehension of clinical practice guidelines for EC were significant predictors for their proficiency.

研究背景本研究旨在调查中国农村全科医生(GPs)对食管癌(EC)防治知识的掌握情况,并分析相关影响因素,从而提高农村全科医生的食管癌防治能力:本横断面研究于 2021 年 11 月 5 日至 2021 年 11 月 20 日进行。采用自行设计的问卷进行在线调查。采用多变量逻辑回归模型确定中国农村全科医生对心血管疾病防治知识掌握程度的影响因素:本研究纳入了来自河北省 12 个农村地区的 348 名参与者。所有问题的平均正确率为 42.3% ± 10.67%。性别(OR=2.870,95% CI:1.519-5.423)、受教育程度(OR=3.256,95% CI:1.135-9.339)和对EC临床实践指南的理解(OR=4.305,95% CI:2.023-9.161)是全科医生EC防治知识熟练程度的显著预测因素(P<0.05):研究表明,农村全科医生的心血管疾病防治知识水平仍有待提高。性别、受教育程度和对心血管疾病临床实践指南的理解程度是预测全科医生对心血管疾病防治知识掌握程度的重要因素。
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引用次数: 0
Educational interventions for health professionals managing chronic obstructive pulmonary disease in primary care. 对初级保健中管理慢性阻塞性肺病的医疗专业人员进行教育干预。
Pub Date : 2024-02-12 DOI: 10.1017/S1463423623000609
Daksha Trivedi
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引用次数: 0
Bridging the first-aid knowledge gap: a cross-sectional study of medical scope students in Syria. 缩小急救知识差距:对叙利亚医学专业学生的横断面研究。
Pub Date : 2024-02-08 DOI: 10.1017/S1463423624000033
Jamal Ataya, Jawdat Ataya, Ziad Aljarad

Introduction and objective: Sufficient knowledge required to deal with emergencies at the accident site may not be found in most medical students due to the lack of effective first-aid training in most medical education curricula. This study aims to assess and evaluate medical students' knowledge level in providing first-aid care, especially first-year students.

Methods: An electronic questionnaire was distributed via social media to 1,855 medical students in October 2020. The knowledge level was assessed based on scores obtained for each clinical scenario requiring first aid and classified as good, intermediate, or weak. Statistical analysis was performed using SPSS software.

Results: The study found that academic year and specialization significantly influence medical students' first-aid knowledge level. However, demographic factors such as gender, university, marital status, housing status, work status, financial condition, and previous first-aid training did not show any significant effect.

Conclusion: The level of knowledge among Syrian medical students in providing first-aid care is somewhat limited. Therefore, first-aid courses should be made more accessible to these students, and their effectiveness should be ensured and maintained through frequent updates. Moreover, more attention should be placed on publicizing first-aid knowledge to make life-saving procedures attainable to anyone, anytime and anywhere.

导言和目的:由于大多数医学教育课程中缺乏有效的急救培训,大多数医科学生可能不具备在事故现场处理紧急情况所需的足够知识。本研究旨在评估医科学生(尤其是一年级学生)在提供急救护理方面的知识水平:方法:2020 年 10 月,通过社交媒体向 1855 名医学生发放了电子问卷。根据每个需要急救的临床场景所获得的分数来评估学生的急救知识水平,并将其分为良好、中等和较弱三个等级。统计分析采用 SPSS 软件进行:研究发现,学年和专业对医学生的急救知识水平有显著影响。然而,性别、大学、婚姻状况、住房状况、工作状况、经济条件和以前接受过的急救培训等人口统计学因素并没有显示出明显的影响:结论:叙利亚医科学生的急救知识水平有限。因此,应让这些学生更容易接受急救课程,并通过经常更新来确保和维持课程的有效性。此外,应更加重视宣传急救知识,使任何人在任何时间、任何地点都能掌握救生程序。
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引用次数: 0
Feasibility of a home-designed respiratory rehabilitation program for chronic obstructive pulmonary disease. 家庭设计的慢性阻塞性肺病呼吸康复计划的可行性。
Pub Date : 2024-01-30 DOI: 10.1017/S1463423623000324
Nidhal Belloumi, Chaima Habouria, Imen Bachouch, Meriem Mersni, Fatma Chermiti, Soraya Fenniche

Background: According to international guidelines, respiratory rehabilitation (RR) for patients with chronic obstructive pulmonary disease (COPD) is a cornerstone of standard non-pharmacological treatment.

Aims: To evaluate feasibility of a home-designed RR program and analyze its medium-term impact on respiratory parameters and quality of life.

Methods: This was a prospective study involving 74 COPD patients enrolled in January 2019 and put on inhaled bronchodilator treatment associated with RR at home following a written protocol, for 16 weeks. The comparative statistical analysis highlights the difference before and after RR in terms of clinical and functional respiratory parameters as well as in terms of quality of life (assessed on the short form 36 (SF-36) questionnaire). The comparison involves RR-adherent patients versus non-adherent patients.

Results: Mean age was 66.7 ± 8.3 years with a median of 67 years. All patients were smokers, out of which 42 patients (57%) did not quit yet. Forty-one percent of patients were frequent exacerbators. The average COPD assessment test (CAT) score in our patients was 23. The average 6-minutes walk distance (MWD) was 304 m. The BODE index in our patients was 4.11 on average. The RR program was followed by 36 patients (48%). Thirty patients (40%) applied it at least twice a week. RR-adherent patients had an average CAT score decreasing from 23 to 14.5 (P = 0.011). Their average 6-MWD was 444.6 m by the end of the study, which would be 64.2% of the calculated theoretical value. The average FEV1 increase after RR was 283 mL. The majority (69%) of RR-adherent patients were ranked as quartile 1; BODE index ≤2. The average scores of physical, psycho-social, and general dimensions assessed on the SF-36 questionnaire improved in RR-adherent patients.

Conclusions: RR is a key non-pharmacological treatment for COPD. Its interest originates from its multidisciplinary nature, hence its effectiveness in several respiratory parameters. Our study reflects the feasibility of home-designed protocols in the absence of contraindications. We highlight also the positive impact on quality of life after RR at home.

背景:根据国际指南,慢性阻塞性肺疾病(COPD)患者的呼吸康复(RR)是标准非药物治疗的基石。目的:评估家庭设计的 RR 计划的可行性,并分析其对呼吸参数和生活质量的中期影响:这是一项前瞻性研究,共有 74 名慢性阻塞性肺疾病患者于 2019 年 1 月入组,并按照书面方案在家中接受与 RR 相关的吸入式支气管扩张剂治疗,为期 16 周。对比统计分析强调了RR前后在临床和功能性呼吸参数以及生活质量(通过简表36(SF-36)问卷进行评估)方面的差异。比较对象包括坚持 RR 的患者和未坚持 RR 的患者:平均年龄为 66.7 ± 8.3 岁,中位数为 67 岁。所有患者均为吸烟者,其中 42 名患者(57%)尚未戒烟。41%的患者病情经常恶化。患者的慢性阻塞性肺病评估测试(CAT)平均得分为 23 分。患者的 BODE 指数平均为 4.11。有 36 名患者(48%)采用了 RR 方案。30名患者(40%)每周至少坚持两次。坚持 RR 的患者的平均 CAT 分数从 23 分降至 14.5 分(P = 0.011)。研究结束时,他们的平均 6-MWD 为 444.6 米,是计算出的理论值的 64.2%。RR 后 FEV1 平均增加 283 毫升。大多数(69%)坚持 RR 的患者被列为四分位 1;BODE 指数≤2。坚持 RR 的患者在 SF-36 问卷中的身体、社会心理和一般方面的平均得分均有所提高:RR是治疗慢性阻塞性肺病的主要非药物疗法。结论:RR 是治疗慢性阻塞性肺病的一种重要的非药物疗法,它的意义在于它的多学科性,因此在多个呼吸参数方面都很有效。我们的研究反映了在没有禁忌症的情况下,家庭设计方案的可行性。我们还强调了在家进行 RR 后对生活质量的积极影响。
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引用次数: 0
Double positivity for rheumatoid factor and anti-CCP autoantibodies: improving referral from primary care of patients suspected of having rheumatoid arthritis. 类风湿因子和抗CCP自身抗体双阳性:改善基层医疗机构对疑似类风湿性关节炎患者的转诊。
Pub Date : 2024-01-17 DOI: 10.1017/S1463423623000695
Maria Salinas, Álvaro Blasco, Emilio Flores, Mauricio Minguez, Carlos Leiva-Salinas

Background: Rheumatoid arthritis (RA) is a chronic progressive autoimmune inflammatory disease with significant morbidity and mortality. The course of the disease can be modified if diagnosis is early and treatment appropriate.

Aim: In this study, we aimed to evaluate a new strategy for early identification of RA patients in primary care settings (the 'diagnostic bottleneck') based on serological biomarkers and to manage inappropriate rheumatoid factor (RF) laboratory test requests.

Method: A two-arm study was carried out. The first arm corresponded to a retrospective observational descriptive study of patients referred for RF testing from primary care using the current laboratory workflow. The second arm included the following prospective interventions: cancelation of RF requests corresponding to patients with previous negative results for RF over a one-year period; and automatic reflex testing antibodies against cyclic citrullinated proteins (anti-CCP) for patients displaying RF values >30 IU/ml. Outcomes from both arms were then compared.

Findings: As double positivity for RF and anti-CCP notably increases the positive likelihood ratio of RA. The intervention enabled a reduction of 2813 tests in 22 months. Moreover, the frequency of unnecessary referrals was reduced from 22% to 8.2%, while that of missed patients decreased slightly (from 21% to 16%), with the number of patients diagnosed per RF request remaining unchanged. In terms of costs, we saved 19.4 RF tests per anti-CCP test added.We developed a simple and cost-effective strategy for reducing the time to diagnosis of RA that can improve patients' quality of life. This approach was supported by primary and specialised care.

背景:类风湿性关节炎(RA)是一种慢性进行性自身免疫性炎症疾病,发病率和死亡率都很高。目的:在这项研究中,我们旨在评估一种基于血清学生物标志物的新策略,以便在初级医疗机构("诊断瓶颈")中早期识别 RA 患者,并管理不适当的类风湿因子(RF)实验室检测请求:方法:开展了一项双臂研究。方法:该研究分为两部分,第一部分是对基层医疗机构转诊的类风湿因子检测患者进行回顾性观察和描述性研究,采用的是当前的实验室工作流程。第二组包括以下前瞻性干预措施:取消一年内射频检测结果为阴性的患者的射频检测申请;对射频检测值大于 30 IU/ml 的患者自动反射检测环瓜氨酸蛋白抗体(抗CCP)。然后对两组结果进行比较:研究结果:RF 和抗-CCP 双阳性明显增加了 RA 的阳性可能性比。干预措施在 22 个月内减少了 2813 次检测。此外,不必要的转诊率从 22% 降至 8.2%,而漏诊率则略有下降(从 21% 降至 16%),但每次射频请求确诊的患者人数保持不变。在成本方面,每增加一次抗CCP检测,我们就能节省19.4次RF检测。我们开发了一种简单、经济有效的策略,缩短了RA的诊断时间,改善了患者的生活质量。这种方法得到了初级和专业护理的支持。
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Primary health care research & development
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