Pub Date : 2022-01-01Epub Date: 2022-04-24DOI: 10.21801/ppcrj.2022.81.5
Luis Castelo-Branco, Alejandra Cardenas-Rojas, Kevin Pacheco-Barrios, Paulo E P Teixeira, Paola Gonzalez-Mego, Karen Vasquez-Avila, Pablo Costa Cortez, Anna Marduy, Ingrid Rebello-Sanchez, Joao Parente, Sammer Marzouk, Felipe Fregni
{"title":"Can neural markers be used for fibromyalgia clinical management?","authors":"Luis Castelo-Branco, Alejandra Cardenas-Rojas, Kevin Pacheco-Barrios, Paulo E P Teixeira, Paola Gonzalez-Mego, Karen Vasquez-Avila, Pablo Costa Cortez, Anna Marduy, Ingrid Rebello-Sanchez, Joao Parente, Sammer Marzouk, Felipe Fregni","doi":"10.21801/ppcrj.2022.81.5","DOIUrl":"https://doi.org/10.21801/ppcrj.2022.81.5","url":null,"abstract":"","PeriodicalId":74496,"journal":{"name":"Principles and practice of clinical research (2015)","volume":"8 1","pages":"28-33"},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9172964/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71429998","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Deferasirox on COVID-19: safety and efficacy of iron-chelating therapy. A multicentric, randomized, triple blinded study","authors":"Natália Garcia, A. Gutierrez-Martinez, Elly Pichardo, Irvianny Madera, Lorgis Jiménez, Nicolle Batlle, Katherine Calderón","doi":"10.21801/ppcrj.2021.74.5","DOIUrl":"https://doi.org/10.21801/ppcrj.2021.74.5","url":null,"abstract":"","PeriodicalId":74496,"journal":{"name":"Principles and practice of clinical research (2015)","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48793631","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-12-31DOI: 10.21801/ppcrj.2021.74.4
Guillermo Droppelmann, Akira Saavedra, Felipe Apablaza, A. Macedo
{"title":"The effect of regenerative therapy in functional outcome in the treatment of patellar and Achilles tendinopathy: A Meta-analysis of Randomized Controlled Clinical Trials","authors":"Guillermo Droppelmann, Akira Saavedra, Felipe Apablaza, A. Macedo","doi":"10.21801/ppcrj.2021.74.4","DOIUrl":"https://doi.org/10.21801/ppcrj.2021.74.4","url":null,"abstract":"","PeriodicalId":74496,"journal":{"name":"Principles and practice of clinical research (2015)","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47089357","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-12-31DOI: 10.21801/ppcrj.2021.74.6
A. F. Herrera Ortiz, Eduard Cadavid Camacho, Julián Cubillos Rojas, Tatiana Cadavid Camacho, Stephani Zoe Guevara, Nury Tatiana Rincón Cuenca, Andrés Vásquez Perdomo, Valeria del Castillo Herazo, Rubén Giraldo Malo
{"title":"A Practical Guide to Perform a Systematic Literature Review and Meta-analysis","authors":"A. F. Herrera Ortiz, Eduard Cadavid Camacho, Julián Cubillos Rojas, Tatiana Cadavid Camacho, Stephani Zoe Guevara, Nury Tatiana Rincón Cuenca, Andrés Vásquez Perdomo, Valeria del Castillo Herazo, Rubén Giraldo Malo","doi":"10.21801/ppcrj.2021.74.6","DOIUrl":"https://doi.org/10.21801/ppcrj.2021.74.6","url":null,"abstract":"","PeriodicalId":74496,"journal":{"name":"Principles and practice of clinical research (2015)","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46594190","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-12-31DOI: 10.21801/ppcrj.2021.74.7
María Isabel Marte, Elly Pichardo, Vahid Nouri Kandany, Máxima Méndez Castillo
{"title":"Acceptance towards COVID-19 vaccine: A cross-sectional study in the Dominican Republic.","authors":"María Isabel Marte, Elly Pichardo, Vahid Nouri Kandany, Máxima Méndez Castillo","doi":"10.21801/ppcrj.2021.74.7","DOIUrl":"https://doi.org/10.21801/ppcrj.2021.74.7","url":null,"abstract":"","PeriodicalId":74496,"journal":{"name":"Principles and practice of clinical research (2015)","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48862549","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-12-26DOI: 10.21801/ppcrj.2021.74.3
P. Trinh, Barbara Tafuto, Yasheca T Ebanks, Zahra Zunaed, D. Lechner
Quality research management is the cornerstone of clinical and translational science. In 2006, the NIH National Center for Advancing Translational Sciences (NCATS) created the Clinical and Translational Science Awards (CTSA) program to train new generations of clinical and translational researchers (Patel et al., 2019). While 60+ academic medical centers have created workforce development programs through CTSA funding, evaluating the use and comparative efficacy of competency-based assessment tools to understand the effectiveness of these programs has remained unreported. Competency-based selfassessment tools (CBSTs) are question-based instruments to evaluate one’s confidence in specific professional competencies with an implicit assumption that confidence may translate into competency (Robinson et al., 2013). CBSTs would allow programs to measure indirectly key professional development milestones of trainees. Currently, several CBSTs exist to assess individuals in specific clinical research roles, such as principal investigator, clinical research coordinator, and other ancillary research staff (Hornung, Ianni, Jones, Samuels, & Ellingrod, 2019; Hornung et al., 2018; Mullikin, Bakken, & Betz, 2007), but little has been reported about the use or need for CBSTs within the CTSA community. Consequently, the New Jersey Alliance for Clinical and Translational Science (NJ ACTS) Workforce Development Core conducted a CTSA consortium-wide assessment to evaluate the present use and potential need for CBSTs in evaluating CTSA trainees. This work is a retrospective analysis of those materials, conducted to understand both the utility of CBSTs as an evaluation component to CTSA workforce development activities and which professional competencies are valued.
质量研究管理是临床和转化科学的基石。2006年，美国国立卫生研究院国家促进转化科学中心(NCATS)创建了临床和转化科学奖(CTSA)计划，以培训新一代临床和转化研究人员(Patel等人，2019)。虽然60多个学术医疗中心通过CTSA的资助创建了劳动力发展项目，但评估基于能力的评估工具的使用和比较效果，以了解这些项目的有效性，仍然没有报道。基于能力的自我评估工具(CBSTs)是一种基于问题的工具，用于评估一个人对特定专业能力的信心，并隐含假设信心可以转化为能力(Robinson et al.， 2013)。CBSTs将允许项目间接衡量受训者的关键专业发展里程碑。目前，存在一些cbst来评估特定临床研究角色的个体，例如首席研究员，临床研究协调员和其他辅助研究人员(Hornung, Ianni, Jones, Samuels， & Ellingrod, 2019;Hornung et al.， 2018;Mullikin, Bakken， & Betz, 2007)，但关于CTSA社区中cbst的使用或需求的报道很少。因此，新泽西临床和转化科学联盟(NJ ACTS)劳动力发展核心进行了一项CTSA联盟范围内的评估，以评估CBSTs在评估CTSA受训者中的当前使用和潜在需求。这项工作是对这些材料的回顾性分析，旨在了解CBSTs作为CTSA劳动力发展活动的评估组成部分的效用，以及重视哪些专业能力。
{"title":"Competency-Based Self-Assessment Tools: A Mixed-Methods Retrospective Analysis of Need.","authors":"P. Trinh, Barbara Tafuto, Yasheca T Ebanks, Zahra Zunaed, D. Lechner","doi":"10.21801/ppcrj.2021.74.3","DOIUrl":"https://doi.org/10.21801/ppcrj.2021.74.3","url":null,"abstract":"Quality research management is the cornerstone of clinical and translational science. In 2006, the NIH National Center for Advancing Translational Sciences (NCATS) created the Clinical and Translational Science Awards (CTSA) program to train new generations of clinical and translational researchers (Patel et al., 2019). While 60+ academic medical centers have created workforce development programs through CTSA funding, evaluating the use and comparative efficacy of competency-based assessment tools to understand the effectiveness of these programs has remained unreported. Competency-based selfassessment tools (CBSTs) are question-based instruments to evaluate one’s confidence in specific professional competencies with an implicit assumption that confidence may translate into competency (Robinson et al., 2013). CBSTs would allow programs to measure indirectly key professional development milestones of trainees. Currently, several CBSTs exist to assess individuals in specific clinical research roles, such as principal investigator, clinical research coordinator, and other ancillary research staff (Hornung, Ianni, Jones, Samuels, & Ellingrod, 2019; Hornung et al., 2018; Mullikin, Bakken, & Betz, 2007), but little has been reported about the use or need for CBSTs within the CTSA community. Consequently, the New Jersey Alliance for Clinical and Translational Science (NJ ACTS) Workforce Development Core conducted a CTSA consortium-wide assessment to evaluate the present use and potential need for CBSTs in evaluating CTSA trainees. This work is a retrospective analysis of those materials, conducted to understand both the utility of CBSTs as an evaluation component to CTSA workforce development activities and which professional competencies are valued.","PeriodicalId":74496,"journal":{"name":"Principles and practice of clinical research (2015)","volume":"81 1","pages":"23-26"},"PeriodicalIF":0.0,"publicationDate":"2021-12-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90387365","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-12-22DOI: 10.21801/ppcrj.2021.74.1
K. Pacheco-Barrios, Paulo S de Melo, Karen Vásquez-Ávila, A. Cardenas-Rojas, Paola Gonzalez-Mego, A. Marduy, Joao Parente, Ingrid Rebello Sanchez, P. Cortêz, Meghan Whalen, L. Castelo-Branco, F. Fregni
Phantom limb pain (PLP) is defined as a painful sensation in an amputated limb or pain that follows partial or complete deafferentation. It belongs to a group of neuropathic pain syndromes, and its treatment is challenging and often refractory to many modalities, causing significant burden and suffering. The prevalence of PLP after amputation ranges between 60–80% (Limakatso et al., 2020). In some cases, the pain might decrease with time and even fade away, but studies have shown that even after two years, a majority of the patients still present pain, and only a small percentage have reported a decrease in intensity of pain (Erlenwein et al., 2021). To date, there is no guidelines for the treatment of PLP and most therapies have low levels of evidence. Possible treatments include the use of pharmacotherapy including opioids, antidepressants, neuroleptics, muscle relaxants and anticonvulsants (Flor, 2002), a variety of surgical procedures (Nikolajsen & Christensen, 2015), nerve blocks, local anesthesia, transcutaneous electrical nerve stimulation (TENS) (Kern et al., 2012), acupuncture, psychological interventions, physiotherapy, and mind-body techniques such as hypnosis(Bamford, 2006; Moura et al., 2012). Conventional treatments used for PLP, such as pharmacologic agents, have pertinent limitations. The use of pharmacologic agents for controlling pain is associated with several side effects and can become unsustainable in the long term (Els et al.,
幻肢痛(PLP)被定义为截肢肢体的疼痛感觉或部分或完全脱神经后的疼痛。它属于一组神经性疼痛综合征，它的治疗是具有挑战性的，往往是难治性的许多方式，造成巨大的负担和痛苦。截肢后PLP的患病率在60-80%之间(Limakatso et al.， 2020)。在某些情况下，疼痛可能会随着时间的推移而减轻甚至消失，但研究表明，即使在两年后，大多数患者仍然存在疼痛，只有一小部分患者报告疼痛强度减轻(Erlenwein et al.， 2021)。到目前为止，还没有关于PLP治疗的指南，而且大多数治疗方法的证据水平很低。可能的治疗方法包括使用药物治疗，包括阿片类药物、抗抑郁药、神经抑制剂、肌肉松弛剂和抗惊厥药(Flor, 2002)、各种外科手术(Nikolajsen & Christensen, 2015)、神经阻滞、局部麻醉、经皮神经电刺激(TENS) (Kern et al.， 2012)、针灸、心理干预、物理治疗和催眠等身心技术(Bamford, 2006;Moura et al.， 2012)。用于PLP的常规治疗，如药物治疗，有相应的局限性。使用药物来控制疼痛与几种副作用有关，并且从长期来看可能不可持续(Els等人)。
{"title":"Accelerating the translation of research findings to clinical practice: insights from phantom limb pain clinical trials.","authors":"K. Pacheco-Barrios, Paulo S de Melo, Karen Vásquez-Ávila, A. Cardenas-Rojas, Paola Gonzalez-Mego, A. Marduy, Joao Parente, Ingrid Rebello Sanchez, P. Cortêz, Meghan Whalen, L. Castelo-Branco, F. Fregni","doi":"10.21801/ppcrj.2021.74.1","DOIUrl":"https://doi.org/10.21801/ppcrj.2021.74.1","url":null,"abstract":"Phantom limb pain (PLP) is defined as a painful sensation in an amputated limb or pain that follows partial or complete deafferentation. It belongs to a group of neuropathic pain syndromes, and its treatment is challenging and often refractory to many modalities, causing significant burden and suffering. The prevalence of PLP after amputation ranges between 60–80% (Limakatso et al., 2020). In some cases, the pain might decrease with time and even fade away, but studies have shown that even after two years, a majority of the patients still present pain, and only a small percentage have reported a decrease in intensity of pain (Erlenwein et al., 2021). To date, there is no guidelines for the treatment of PLP and most therapies have low levels of evidence. Possible treatments include the use of pharmacotherapy including opioids, antidepressants, neuroleptics, muscle relaxants and anticonvulsants (Flor, 2002), a variety of surgical procedures (Nikolajsen & Christensen, 2015), nerve blocks, local anesthesia, transcutaneous electrical nerve stimulation (TENS) (Kern et al., 2012), acupuncture, psychological interventions, physiotherapy, and mind-body techniques such as hypnosis(Bamford, 2006; Moura et al., 2012). Conventional treatments used for PLP, such as pharmacologic agents, have pertinent limitations. The use of pharmacologic agents for controlling pain is associated with several side effects and can become unsustainable in the long term (Els et al.,","PeriodicalId":74496,"journal":{"name":"Principles and practice of clinical research (2015)","volume":"102 1","pages":"1-7"},"PeriodicalIF":0.0,"publicationDate":"2021-12-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75756584","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-12-19DOI: 10.21801/ppcrj.2021.73.6
María J Romaris, Simone Collopy, Tatiana de Avila Miguel, Mohamed E A Abdelrahim, Carla Renata Curi, Mohammad Altujjar, Khalid Ahmed, Reynie Reynoso Gonel, Arthur Gomes da Silva Netto, Saulo Borges, Joao Paulo Greco de Freitas Cardoso, Ricardo Almeida-Magaña
{"title":"MusT-In Therapy (Effect of Music Therapy and Interaction with Typically Developing Peers) for improving social interaction in children with severe autism spectrum disorder - Study protocol.","authors":"María J Romaris, Simone Collopy, Tatiana de Avila Miguel, Mohamed E A Abdelrahim, Carla Renata Curi, Mohammad Altujjar, Khalid Ahmed, Reynie Reynoso Gonel, Arthur Gomes da Silva Netto, Saulo Borges, Joao Paulo Greco de Freitas Cardoso, Ricardo Almeida-Magaña","doi":"10.21801/ppcrj.2021.73.6","DOIUrl":"https://doi.org/10.21801/ppcrj.2021.73.6","url":null,"abstract":"","PeriodicalId":74496,"journal":{"name":"Principles and practice of clinical research (2015)","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-12-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44692094","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-12-19DOI: 10.21801/ppcrj.2021.73.7
Sara P. Barbosa, L. M. Marques, K. Pacheco-Barrios, M. Imamura, L. Battistella, M. Simis, F. Fregni
{"title":"Designing and conducting observational studies in rehabilitation: challenges and opportunities","authors":"Sara P. Barbosa, L. M. Marques, K. Pacheco-Barrios, M. Imamura, L. Battistella, M. Simis, F. Fregni","doi":"10.21801/ppcrj.2021.73.7","DOIUrl":"https://doi.org/10.21801/ppcrj.2021.73.7","url":null,"abstract":"","PeriodicalId":74496,"journal":{"name":"Principles and practice of clinical research (2015)","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-12-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68355920","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-11-05DOI: 10.21801/ppcrj.2021.73.5
Raquel Costa, Osama Zied Alzobi, S. Al-Busaidi, Diego Arbaje, Catherine Avery Skinner, Victor Batistella, Eleonora Boschetti Grutzmacher, Gabriela Casais, Denisse A. Castro, M. Cohen, Annette García Delgado, Muhammad Haseeb, Veronica Hernandez Leon, Pedro Hilton de Andrade Filho, Brahim Khouri Lopez, A. Marcadenti, J. Müller, Diego Noya Rabelo, Flavia Tarcha, Juliana Tepedino Martins Alves, Francisca Urrutia Goldsack, E. Youssif, A. Tamayo, D. Schwartz, D. D. Garcia Choza, M. Cubria, I. Sulieman
{"title":"Combination of olanzapine with bispectral index guided anesthesia to prevent postoperative delirium in elderly patients undergoing major gastrointestinal elective surgery: a randomized, double-blind, placebo-controlled study protocol","authors":"Raquel Costa, Osama Zied Alzobi, S. Al-Busaidi, Diego Arbaje, Catherine Avery Skinner, Victor Batistella, Eleonora Boschetti Grutzmacher, Gabriela Casais, Denisse A. Castro, M. Cohen, Annette García Delgado, Muhammad Haseeb, Veronica Hernandez Leon, Pedro Hilton de Andrade Filho, Brahim Khouri Lopez, A. Marcadenti, J. Müller, Diego Noya Rabelo, Flavia Tarcha, Juliana Tepedino Martins Alves, Francisca Urrutia Goldsack, E. Youssif, A. Tamayo, D. Schwartz, D. D. Garcia Choza, M. Cubria, I. Sulieman","doi":"10.21801/ppcrj.2021.73.5","DOIUrl":"https://doi.org/10.21801/ppcrj.2021.73.5","url":null,"abstract":"","PeriodicalId":74496,"journal":{"name":"Principles and practice of clinical research (2015)","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-11-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41659909","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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