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TrialView: An AI-powered Visual Analytics System for Temporal Event Data in Clinical Trials. TrialView:用于临床试验中时间事件数据的人工智能可视化分析系统。
Zuotian Li, Xiang Liu, Zelei Cheng, Yingjie Chen, Wanzhu Tu, Jing Su

Randomized controlled trials (RCT) are the gold standards for evaluating the efficacy and safety of therapeutic interventions in human subjects. In addition to the pre-specified endpoints, trial participants' experience reveals the time course of the intervention. Few analytical tools exist to summarize and visualize the individual experience of trial participants. Visual analytics allows integrative examination of temporal event patterns of patient experience, thus generating insights for better care decisions. Towards this end, we introduce TrialView, an information system that combines graph artificial intelligence (AI) and visual analytics to enhance the dissemination of trial data. TrialView offers four distinct yet interconnected views: Individual, Cohort, Progression, and Statistics, enabling an interactive exploration of individual and group-level data. The TrialView system is a general-purpose analytical tool for a broad class of clinical trials. The system is powered by graph AI, knowledge-guided clustering, explanatory modeling, and graph-based agglomeration algorithms. We demonstrate the system's effectiveness in analyzing temporal event data through a case study.

随机对照试验(RCT)是评估人体治疗干预效果和安全性的黄金标准。除了预先指定的终点外,试验参与者的经历也揭示了干预的时间过程。目前很少有分析工具能对试验参与者的个人经历进行总结和可视化。可视化分析可以综合检查患者经历的时间事件模式,从而为更好的护理决策提供洞察力。为此,我们介绍了 TrialView,这是一个结合了图形人工智能(AI)和可视化分析技术的信息系统,可加强试验数据的传播。TrialView 提供四种不同但相互关联的视图:个人视图、队列视图、进展视图和统计视图,可对个人和群体层面的数据进行交互式探索。TrialView 系统是适用于各类临床试验的通用分析工具。该系统由图人工智能、知识引导聚类、解释性建模和基于图的聚类算法提供支持。我们通过一个案例研究展示了该系统在分析时间事件数据方面的有效性。
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引用次数: 0
Informing Acceptability and Feasibility of Digital Phenotyping for Personalized HIV Prevention among Marginalized Populations Presenting to the Emergency Department. 为在急诊科就诊的边缘化人群中开展个性化艾滋病毒预防工作提供数字表型的可接受性和可行性信息。
Tiffany R Glynn, Simran S Khanna, Mohammad Adrian Hasdianda, Jeremiah Tom, Krishna Ventakasubramanian, Arlen Dumas, Conall O'Cleirigh, Charlotte E Goldfine, Peter R Chai

For marginalized populations with ongoing HIV epidemics, alternative methods are needed for understanding the complexities of HIV risk and delivering prevention interventions. Due to lack of engagement in ambulatory care, such groups have high utilization of drop-in care. Therefore, emergency departments represent a location with those at highest risk for HIV and in highest need of novel prevention methods. Digital phenotyping via data collected from smartphones and other wearable sensors could provide the innovative vehicle for examining complex HIV risk and assist in delivering personalized prevention interventions. However, there is paucity in exploring if such methods are an option. This study aimed to fill this gap via a cross-sectional psychosocial assessment with a sample of N=85 emergency department patients with HIV risk. Findings demonstrate that although potentially feasible, acceptability of digital phenotyping is questionable. Technology-assisted HIV prevention needs to be designed with the target community and address key ethical considerations.

对于艾滋病毒持续流行的边缘化人群,需要采用其他方法来了解艾滋病毒风险的复杂性并提供预防干预措施。由于缺乏门诊护理,这些群体对临时护理的利用率很高。因此,急诊科是艾滋病风险最高、最需要新型预防方法的地方。通过智能手机和其他可穿戴传感器收集的数据进行数字表型分析,可为检查复杂的艾滋病风险提供创新工具,并有助于提供个性化的预防干预措施。然而,目前还缺乏对此类方法是否可行的探索。本研究旨在通过对 85 名急诊科艾滋病风险患者进行横断面社会心理评估来填补这一空白。研究结果表明,尽管数字表型具有潜在的可行性,但其可接受性仍值得商榷。技术辅助艾滋病预防需要与目标社区共同设计,并解决关键的伦理问题。
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引用次数: 0
Real-World Implementation Challenges Associated with a Digital Pill System to Measure Adherence to HIV Pre-Exposure Prophylaxis from Two Studies of Men Who Have Sex With Men. 从两项针对男性同性性行为者的研究中发现的用于测量艾滋病暴露前预防依从性的数字药丸系统在现实世界中的实施挑战。
Georgia R Goodman, T Chris Carnes, Hannah Albrechta, Pamela Alpert, Joanne Hokayem, Charlotte Goldfine, Jasper S Lee, Edward W Boyer, Rochelle Rosen, Kenneth H Mayer, Conall O'Cleirigh, Peter R Chai

Once-daily oral pre-exposure prophylaxis (PrEP) is highly effective for HIV prevention, but its efficacy is dependent on adherence, which can be challenging for men who have sex with men (MSM) with substance use. Digital pill systems (DPS) represent a novel tool for directly measuring adherence through ingestible radiofrequency sensors that confirm ingestions in real-time. We examined operational challenges across two studies involving DPS to measure PrEP adherence. While most participants successfully operated the system, a number of technological and sociobehavioral challenges requiring intervention were identified across both studies. Technological issues were both system- and participant-related, and were primarily addressed with technical updates and participant re-education, while sociobehavioral issues, including health and housing changes and issues with technology access, warranted innovative solutions. Future research leveraging DPS technology should develop robust supportive infrastructure and mitigation procedures to promptly identify and resolve operational issues to optimize the potential benefits of DPS use.

每日一次的口服暴露前预防疗法(PrEP)对预防艾滋病非常有效,但其疗效取决于依从性,而这对使用药物的男男性行为者(MSM)来说可能具有挑战性。数字药丸系统(DPS)是一种通过可摄取射频传感器直接测量依从性的新型工具,可实时确认摄取量。我们在两项涉及 DPS 的研究中研究了操作难题,以衡量 PrEP 的依从性。虽然大多数参与者都成功地操作了该系统,但在两项研究中都发现了一些需要干预的技术和社会行为挑战。技术问题既与系统有关,也与参与者有关,主要通过技术更新和参与者再教育来解决,而社会行为问题,包括健康和住房变化以及技术访问问题,则需要创新的解决方案。未来利用 DPS 技术进行的研究应开发强大的支持性基础设施和缓解程序,以便及时发现和解决操作问题,优化 DPS 使用的潜在效益。
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引用次数: 0
Out with the Old, In with the New: Examining National Cybersecurity Strategy Changes over Time 旧的去了,新的来了:审视国家网络安全战略的变化
W. Cram, Jonathan Yuan
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引用次数: 0
The Roles of Digital Exhibition in Enhancing Immersive Experience and Purchase Intention 数字展览对增强沉浸式体验和购买意愿的作用
S. Yoon, Jai-Yeol Son
Museums in modern society serve to a broader public than their early predecessors. In response to such transition, many art museums now open digital exhibitions to provide immersive experience and maximize user interaction. This paper focuses on two such features – animated image and storytelling description – and their effect on museum visitors’ immersive experience and willingness-to-pay price premium (WTP). Our results indicate that animated images and storytelling description not only enhance immersion and WTP but also are more effective when adopted together. This paper contributes to both IS literature and museum industry by providing comprehensive understandings of how digital exhibition features enhance museum visitors’ immersive experience and purchase intention.
现代社会的博物馆比它们早期的前辈服务于更广泛的公众。为了应对这种转变,许多美术馆现在都开设了数字展览,以提供沉浸式体验和最大化用户互动。本文主要研究了动画形象和故事描述这两个特征对博物馆参观者沉浸式体验和支付溢价意愿的影响。我们的研究结果表明,动画图像和故事描述不仅可以增强沉浸感和WTP,而且当它们同时使用时效果更好。本文通过对数字展览特征如何增强博物馆参观者沉浸式体验和购买意愿的全面理解,对IS文献和博物馆行业都有贡献。
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引用次数: 1
Designing an AI compatible open government data ecosystem for public governance 设计兼容人工智能的公共治理开放政府数据生态系统
E. Tan
AI solutions can significantly leverage open government data (OGD) ecosystems in public governance. For that, it is important to design effective and transparent governance mechanisms that create value in an OGD ecosystem through AI solutions. This article develops a conceptual model for a systematic design of an OGD governance model, which adopts a platform governance approach and integrates the governance needs derived from the use of AI. The purpose of the conceptual model is to systematically identify and analyze the interrelationships among multiple change factors on OGD governance design and to project available AI-based solutions for the OGD ecosystem by assessing the managerial, organizational, legal, technological, moral, and institutional variances. The proposed ‘6-step model’ suggests that an AI-compatible OGD ecosystem design requires (i) identifying contingencies, (ii) identifying data prosumers, (iii) assigning data governance roles, (iv) identifying design values, (v) designing the governance of AI, and (vi) designing the governance by AI. Through the recursive and reflexive analysis of each step, policymakers and system designers can develop reliable strategies in leveraging AI solutions for the use of OGD in public governance.
人工智能解决方案可以在公共治理中显著利用开放政府数据(OGD)生态系统。为此,重要的是设计有效和透明的治理机制,通过AI解决方案在OGD生态系统中创造价值。本文为OGD治理模型的系统设计开发了一个概念模型,该模型采用平台治理方法,并集成了使用人工智能产生的治理需求。概念模型的目的是系统地识别和分析OGD治理设计中多个变化因素之间的相互关系,并通过评估管理、组织、法律、技术、道德和制度差异,为OGD生态系统规划可用的基于人工智能的解决方案。提出的“6步模型”表明,与人工智能兼容的OGD生态系统设计需要(i)识别偶然性,(ii)识别数据产消者,(iii)分配数据治理角色,(iv)识别设计价值,(v)设计人工智能治理,(vi)设计人工智能治理。通过对每个步骤的递归和反射性分析,政策制定者和系统设计者可以制定可靠的策略,利用人工智能解决方案在公共治理中使用OGD。
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引用次数: 0
Pushing for Social Change: How Collaborations Are Recalibrating the Journalistic Mission 推动社会变革:合作如何重新校准新闻使命
P. Walters
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引用次数: 2
Network Inspection Using Heterogeneous Sensors for Detecting Strategic Attacks 基于异构传感器的网络检测策略攻击
Bobak Mccann, Mathieu Dahan
We consider a two-player network inspection game, in which a defender allocates sensors with potentially heterogeneous detection capabilities in order to detect multiple attacks caused by a strategic attacker. The objective of the defender (resp. attacker) is to minimize (resp. maximize) the expected number of undetected attacks by selecting a potentially randomized inspection (resp. attack) strategy. We analytically characterize Nash equilibria of this large-scale zero-sum game when every vulnerable network component can be monitored from a unique sensor location. We then leverage our equilibrium analysis to design a heuristic solution approach based on minimum set covers for computing inspection strategies in general. Our computational results on a benchmark cyber-physical distribution network illustrate the performance and computational tractability of our solution approach.
我们考虑一个双玩家网络检测游戏,其中防御者分配具有潜在异构检测能力的传感器,以检测由战略攻击者引起的多重攻击。防守者的目标是什么?攻击者)是最小化(响应)。通过选择可能随机化的检查(resp.),最大化未检测到的攻击的预期数量。攻击)的策略。当每个脆弱的网络组件都可以从一个独特的传感器位置进行监控时,我们分析表征了这种大规模零和博弈的纳什均衡。然后,我们利用我们的均衡分析来设计一种基于最小集覆盖的启发式解决方法,用于计算一般的检查策略。我们在一个基准网络-物理分配网络上的计算结果说明了我们的解决方法的性能和计算可追溯性。
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引用次数: 2
Energy Efficiency of Training Neural Network Architectures: An Empirical Study 训练神经网络架构的能量效率:一个实证研究
Yi Xu, Silverio Mart'inez-Fern'andez, Matias Martinez, Xavier Franch
The evaluation of Deep Learning models has traditionally focused on criteria such as accuracy, F1 score, and related measures. The increasing availability of high computational power environments allows the creation of deeper and more complex models. However, the computations needed to train such models entail a large carbon footprint. In this work, we study the relations between DL model architectures and their environmental impact in terms of energy consumed and CO$_2$ emissions produced during training by means of an empirical study using Deep Convolutional Neural Networks. Concretely, we study: (i) the impact of the architecture and the location where the computations are hosted on the energy consumption and emissions produced; (ii) the trade-off between accuracy and energy efficiency; and (iii) the difference on the method of measurement of the energy consumed using software-based and hardware-based tools.
传统上,深度学习模型的评估主要集中在准确性、F1分数和相关措施等标准上。高计算能力环境的日益可用性允许创建更深入和更复杂的模型。然而,训练这些模型所需的计算需要大量的碳足迹。在这项工作中,我们通过使用深度卷积神经网络的实证研究,从训练过程中产生的能量消耗和CO$_2$排放的角度研究了深度学习模型架构与其环境影响之间的关系。具体来说,我们研究:(i)建筑和计算地点对产生的能源消耗和排放的影响;(ii)准确性和能源效率之间的权衡;(三)基于软件和基于硬件的能源消耗测量方法的差异。
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引用次数: 4
PULL: Reactive Log Anomaly Detection Based On Iterative PU Learning 基于迭代PU学习的反应性日志异常检测
Thorsten Wittkopp, Dominik Scheinert, Philipp Wiesner, Alexander Acker, O. Kao
Due to the complexity of modern IT services, failures can be manifold, occur at any stage, and are hard to detect. For this reason, anomaly detection applied to monitoring data such as logs allows gaining relevant insights to improve IT services steadily and eradicate failures. However, existing anomaly detection methods that provide high accuracy often rely on labeled training data, which are time-consuming to obtain in practice. Therefore, we propose PULL, an iterative log analysis method for reactive anomaly detection based on estimated failure time windows provided by monitoring systems instead of labeled data. Our attention-based model uses a novel objective function for weak supervision deep learning that accounts for imbalanced data and applies an iterative learning strategy for positive and unknown samples (PU learning) to identify anomalous logs. Our evaluation shows that PULL consistently outperforms ten benchmark baselines across three different datasets and detects anomalous log messages with an F1-score of more than 0.99 even within imprecise failure time windows.
由于现代IT服务的复杂性,故障可能是多种多样的,发生在任何阶段,并且很难检测到。出于这个原因,应用于监视数据(如日志)的异常检测可以获得相关的见解,从而稳定地改进IT服务并消除故障。然而,现有的高精度异常检测方法往往依赖于标记的训练数据,在实践中获得这些数据非常耗时。因此,我们提出了PULL,这是一种基于监测系统提供的估计故障时间窗口而不是标记数据的响应性异常检测的迭代日志分析方法。我们的基于注意力的模型使用了一种新的弱监督深度学习目标函数,该目标函数考虑了不平衡数据,并对正样本和未知样本(PU学习)应用迭代学习策略来识别异常日志。我们的评估表明,PULL在三个不同的数据集上始终优于10个基准,并且即使在不精确的故障时间窗口内,也可以检测到f1分数超过0.99的异常日志消息。
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引用次数: 2
期刊
Proceedings of the ... Annual Hawaii International Conference on System Sciences. Annual Hawaii International Conference on System Sciences
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