Recent advances in food, nutrition & agriculture最新文献

Background: Aegle marmelos, an Indian plant, has been extensively utilized by the people of the Indian subcontinent over about 5000 years. The leaves, bark, roots, and fruits, including seeds, are widely used to cure a variety of diseases in the Indian traditional system of medicine, Ayurveda, along with numerous folk medicines. By revealing the existence of significant bioactive chemicals, modern research has effectively substantiated the therapeutic effects of bael.

Objective: The objective of this study was to review the literature regarding A. marmelos geographical distribution, morphology, therapeutic benefits, and phytochemicals found in the bael leaves, fruits, and other parts of the plant that offer a wide range of pharmacological applications in neurological disorders.

Methodology: A thorough literature search was conducted using five computerized databases, such as PubMed, Google Scholar, ScienceDirect, Elsevier, and Wiley Online Library (WOL), by using standard keywords "A. marmelos," "Geographical distribution," "Morphological description," "Ethnobotanical Uses," "Phytoconstituents" and "Neuroprotective activities" for review papers published between 1975 and 2023. A small number of earlier review articles focused on phyto-pharmacological potential of Aegle marmelos (L.) for neurological disorders.

Results: According to some research, Aegle marmelos extracts potentially have neuroprotective benefits. This is due to its capacity to alter cellular mechanisms that cause neuronal damage.

Conclusion: Neurodegenerative illnesses usually induce permanent neuronal network loss overall the brain along with the spinal cord (CNS), resulting in chronic functional impairments. The review summarizes the multiple aspects and processes of A. marmelos extract and its components in several models of neurodegenerative diseases such as anxiety, epilepsy, depression, Parkinson's disease, Alzheimer's disease, and others. MDA, nitrite, TNF-, and IL-6 levels were dramatically elevated, whereas glutathione levels were significantly lowered in the hippocampus of STZ-treated rats. Furthermore, STZ-treated rats showed a substantial drop in catalase activity and an increase in AChE activity, indicating cholinergic hypofunction and neuronal injury. The neuroprotective ability of A. marmelos against STZ-induced oxidative stress and cognitive loss in rats suggests that it has therapeutic relevance in Alzheimer's disease (AD).

Introduction: Pacu (Piaractus mesopotamicus) is a Brazilian fish species of high commercial value and has emerged as one of the main species with potential f o r intensive farming. This study aimed to investigate the impact of choline supplementation on productive performance, visceral fat, hepatosomatic indices, proximate composition, serum biochemical profile, and liver coloration in juvenile pacu (Piaractus mesopotamicus).

Method: The 60-day experiment was conducted in the experimental hatchery of the Study Group of Aquaculture Management - GEMAq of the State University of West Paraná, Brazil. The completely randomized design consisted of five treatments with four replicates each. A total of 200 fish, with an average initial weight and length of 4.25 g and 5.97 cm, were distributed among 20 experimental hapas, resulting in a stocking density of 10 fish per experimental unit. Fish fed a choline-deficient diet exhibited the lowest values for final weight, weight gain, visceral fat, and hepatosomatic index. Conversely, in terms of proximate composition, fish fed choline-deficient diets had the highest moisture content and the lowest crude fat content. Triglyceride levels in juvenile pacu were significantly higher in groups fed diets containing choline (400 to 1200 mg kg-1). We also observed significant differences in the cyan color of the liver (P < 0.05). Other parameters did not exhibit significant changes in response to varying choline levels in the diets.

Result: Our study demonstrated that choline supplementation in P. mesopotamicus juveniles at an optimal concentration of 400 mg kg^-1 significantly impacted growth, metabolism, productive performance, proximate composition, biochemical parameters, and liver color.

Conclusion: These findings offer crucial guidance for aquaculture professionals, enabling them to enhance growth and health in P. mesopotamicus farming. Further research on choline's influence on lipid metabolism holds potential for more precise dietary recommendations, ultimately improving the efficiency and sustainability of aquaculture practices for this species.

Accurate prediction of breeding values is challenging due to the genotype-phenotype relationship is crucial and necessary for producing crops with elite genotypes. This paper is about investigating and predicting the phenotypic trait Height and Yeild in a genotype.

Background: Most of the existing studies focus on genetic methods or Machine learning models, in this, we implemented a hybrid combination of genetic methods and machine learning models that accurately predicted phenotypic trait yield, height and subpopulation.

Methodology: Our proposed methodology for genomic prediction of yield in Oryza sativa (rice) involves a two-level classification approach. First, we classify biological sequences and cluster them using the UPGMA algorithm on a phylogenetic tree. Then, we use advanced machine learning techniques like Random Forest, and K-Nearest Neighbours to predict GEBVs with 85-95% accuracy on rice subpopulations.

Results: we achieved an accuracy of 93% when compared with other stated literature in this paper.

Conclusion: This approach overcomes limitations and effectively enhances crop breeding by capturing the genotype-phenotype relationship.

A metabolic disease that requires insulin and is marked by consistently high blood sugar levels is known as diabetes mellitus. Many healthcare systems throughout the world have long relied on medicinal herbs as a means of addressing diabetes and its complications. Traditional medicine derived from plant extracts has several advantages over contemporary pharmaceuticals, including lower costs, greater clinical efficacy, and fewer side effects. Pri-marily, the condition has been managed by a range of synthetic medications that improve the altered glycemic state in individuals with diabetes. Synthetic medications work well, but along with their benefits, they come with noticeable adverse effects. Due to the lack of knowledge regarding their chemical composition, preparation method, active bio-actives, potential side effects, and the optimal way to administer them, medicinal plants have not been fully utilised as acceptable drugs in the treatment of diabetes, despite their long history of use as primary health care. Because of a lack of sufficient data on the parameters described earlier, most medicinal plants that show promise as anti-diabetic agents do not make it to the clinical trial phase. Medicinal plants that have been studied in humans with diabetes and shown promise as a treatment for the disease, either alone or in conjunction with other plants, are summarised in this review. Pharmacologically active phytomolecules with an antidia-betic action that are derived from medicinal plants were the primary topic of this review article. Its goal was to discuss their importance in diabetes management and therapy. These all-natural substances have the potential to be successful and alternative diabetes treatments, as well as a new method of approaching the disease.

Background: Pomelo albedo peel byproducts are composed of many health-ben-eficial phytochemicals during processing. This study aimed to maximize the potential of incorporating pomelo albedo powder as a bioactive ingredient in pasta.

Methods: In the present study, pomelo albedo was fortified with pasta at five different con-centrations (0, 3, 6, 9, and 12%), and its effects on the antioxidant, functional, textural, and sensorial attributes of pasta were investigated.

Results: The results showed that the incorporation of albedo powder remarkably elevated the antioxidant properties and significantly increased the WAC (121.23 to 188.97%) and OAC (110.15 to 136.55%). An increase in pomelo albedo is associated with a decrease in cooking time from 10.24 to 8.28 min with cooking loss that is within an acceptable range. The pomelo albedo formulation improved the color and sensorial attributes. A higher albedo concentration significantly reduced the breaking stress, fracturability, firmness, and hard-ness but increased the adhesiveness and cohesiveness of pasta. FTIR spectra revealed the presence of characteristic peaks, and SEM reflects pomelo albedo's impact on the structural integrity of the pasta.

Conclusion: On the basis of physiochemical, cooking, and sensory data, pasta with a 6% pomelo albedo formulation was found to be the most acceptable, with an overall acceptabil-ity of 8.51. Thus, pomelo albedo can be incorporated into the industry for the preparation of pasta with enhanced nutritional characteristics.

Aims/background: Obesity is characterized by excessive body fat and is a chronic and complex disease. The medications used to date for the treatment of obesity have exhibited various side effects. Thus, new substances must be sought from alternative sources as anti-obesity drugs. Recently, there has been increased interest in the study of bioactive peptides generated from plant proteins for functional food development. Plant proteins have exhibited pancreatic lipase inhibitory activity and can be potentially studied as sources of anti-obesity drugs for long-term use. Amaranthus cruentus seeds are very nutritious, with high protein con-tent and medicinal properties. Hence, this study focuses on pancreatic lipase inhibitory activity and functional properties of Amaranthus cruentus seed protein isolates.

Materials and methods: Proteins were isolated using conventional and thermal isoelectric pre-cipitation methods. The protein's ability to inhibit lipases was assessed using both synthetic and natural substrates. The functional properties, such as nitrogen solubility, foaming test, emulsi-fication test, and water and oil holding abilities, were evaluated. The protein isolates were char-acterized by SDS-PAGE and DSC. Cell line studies were performed on 3T3-L1 cell lines to determine the cytotoxicity and anti-adipogenic activity of protein isolates.

Results: Proteins 1, 2, 3, and 4 were found to have high protein yield and protein content. SDS-PAGE characterization showed protein bands at different molecular weights (kDa). Protein iso-lates demonstrated good functional properties and antilipase activity as compared to flour. In the cell line experiments, protein 1 exhibited a dose-dependent reduction in the lipid content.

Conclusion: A. cruentus seed protein could pave the way for the development of nutraceutical formulation in the treatment of obesity.

Background: Pasta is consumed worldwide and can be an excellent food matrix for supplementation. Grapefruit (Citrus paradisi) flavedo byproduct is reported to contain considerable amounts of bioactive compounds, which represent a valuable and sustainable source of phenolics. So far, there is limited information available about the utilization of grapefruit flavedo byproducts for supplementation of pasta.

Methods: The present study aimed to investigate the effect of freeze-dried grapefruit flavedo powder (GFP) incorporation at various concentrations (3, 6, 9, and 12%) on the phytochem-ical, functional, textural, microstructural, and sensory quality of the developed pasta.

Results: Fortification with GFP significantly (P<0.05) enhanced antioxidant activities rela-tive to DPPH and FRAP and increased the total phenolic and flavonoid content from 73.20-96.83 mg GAE/100g and 132.41-211.63 mg GAE/100g, respectively. Supplementation with GFP significantly (P<0.05) reduced the optimum cooking time of pasta, while cooking loss increased up to 6.32% with 12% GFP incorporation, which was still under the acceptable limits (<8%). The addition of GFP decreased the L* value, while the a* and b* values in-creased for the pasta. SEM analysis presented that GFP incorporation in pasta affected the structural integrity attributable to the enhanced fiber levels, inducing a weaker matrix, as ascertained by textural profile analysis (TPA) with a decline in hardness attribute with in-creasing GFP concentration. Sensory analysis divulged overall acceptability scores of 8.4 for the pasta with 6% GFP, while further increments in GFP levels led to decreased sensory scores.

Conclusion: Grapefruit peels are typically discarded as waste, the outer layer of which, i.e., flavedo, could be used to enrich pasta. The present research divulged that pasta supplemen-tation with freeze-dried flavedo powder could provide total phenolic content, flavonoid con-tent, and antioxidant potential without compromising on the technological and sensory qual-ity of pasta. Utilization of this citrus waste as a bioactive food ingredient with promising effects represents a valuable byproduct valorization strategy.

The purpose of the article is to investigate the therapeutic potential of quer-cetin and related compounds by elucidating their pharmacological characteristics and molecular mechanisms of action. The potential benefits of quercetin and its analogs for cardiovascular health, disorders of the brain, metabolic disorders, and more are discussed in the discussion part of this page. Concerns about their clinical efficacy due to issues with bioavailability and distribution are also discussed. This region of the paper emphasizes the importance of researchers and clinicians working together to maximize the incorporation of these chemicals into real-world therapeutic approaches. In conclusion, quercetin, along with related substances, shows great potential in a wide range of therapeutic settings. Potentially useful for the management of a wide variety of illnesses, their multiple methods of action include the regulation of pathways for cell signaling and interaction with different enzymes. However, additional clinical tri-als are needed to verify their efficacy and safety.

Phytomedicines represent a diverse array of plant-derived compounds renowned for their therapeutic potential. Traditionally, these mixtures were extracted using water or ethanol, but simpler methods like tea infusions are gaining prominence. However, ensuring the efficacy and safety of phytomedicines demands high-quality plant material and stringent production processes. Advancements in biological screening techniques have shed light on the mechanisms of action of phytomedicines, emphasizing the significance of synergistic interactions among their constituents. Ten widely-used phytomedicines are outlined, detailing their applications, efficacy, and safety profiles, underscoring their global importance in healthcare. Moreover, ongoing research in phytomedicine development showcases the rich biodiversity's capacity to yield novel medicinal compounds. These studies highlight the potential of untapped plant sources in providing innovative solutions to medical challenges, offering promising avenues for future therapeutics. In essence, the utilization of phytomedicines underscores a fusion of traditional knowledge with modern scientific approaches, emphasizing both the importance of respecting ancient remedies and harnessing contemporary advancements for improved healthcare outcomes.

Green Revolution aims to boost food production and feed millions of Indians, but it also has negative effects on agriculture and society's health. Natural manures like cow dung and cow urine can counteract the adverse effects of inorganic fertilizer on soil along with improving physicochemical qualities, maintaining the soil quality, and increasing crop output. Zero Budget Natural Farming (ZBNF) formulations like Jivamrit promote soil health and microbial activities and are an excellent source of macronutrients, other micronutrients needed for plant growth, plus adds beneficial microbes, nitrogen (N2), phosphorus (P), potassium (K), and natural carbon (C). Further, conventional agricultural methods, like monocropping and heavy tillage, can damage soil bacteria which contributes to sustainable agriculture through nitrogen fixation, siderophore synthesis and nutrient absorption. A sustainable agricultural system is resource-efficient, socially and commercially competitive, ecologically sound, and supportive of society. Jivamrit, a natural organic manure, is gaining interest due to concerns about the sustainability of input-intensive agriculture systems. It promotes crop growth, quality, and yield, enhances soil pH, population, and activity of beneficial microorganisms, and helps with nitrogen fixation, phosphate solubili-zation, and easy decomposition. Long-term use of Jivamrit, may disrupt soil microbial balance, may leading to overpopulation of certain species. The current review on the Jivamrit emphasizes on the biological and chemical characterization and its significance to the agriculture.