Introduction and aim
Gastroesophageal reflux disease (GERD) is highly prevalent in patients with idiopathic pulmonary fibrosis (IPF), even in the absence of symptoms. Information on this disease in Latin America is limited. The aim of our study was to determine the prevalence of dysmotility and GERD through high-resolution esophageal manometry (HREM) and 24 h multichannel intraluminal impedance-pH (MII-pH) monitoring in IPF patients, candidates for lung transplantation.
Material and methods
A retrospective, descriptive, observational study was conducted at a tertiary care hospital center. HREM and 24 h MII-pH studies were carried out as part of the protocol for lung transplantation candidates. The manometric and impedance data, including the thoracoabdominal pressure gradient (TAPG), were analyzed.
Results
The study included 37 patients. The mean distal contractile integral was 1530.47 mmHg-s-cm (SD ± 1210.03). Fourteen patients (37.8%) presented with ineffective esophageal motility (IEM). The median percentage of acid exposure time (AET) was 3.20% (range: 1.42-4.90) in the patients with IEM versus 0.50% (range: 0.2-2.90) in the patients with normal esophageal motility (p = 0.022). The mean AET percentage was 3.02% (SD ± 4.17) and the mean number of proximal reflux episodes was 25.88 (SD ± 19.37). Five patients (13.5%) had abnormal AET and a mean TAPG of 14.66 mmHg (SD ± 4.89) versus 17.09 mmHg (SD ± 6.92) in patients with AET < 6% (p = 0.457).
Conclusions
Almost 40% of the patients with IPF, who were candidates for lung transplantation, had IEM. However, the prevalence of GERD was low and not associated with changes in the TAPG.
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