Pub Date : 2025-10-01DOI: 10.1016/j.rgmxen.2025.10.024
R. Figueroa-Salazar , M.A. Ruíz-Castillo , E.M. Toro-Monjaraz , L. Casas-Guzik , R. Peña-Vélez , D.V. Bacarreza-Nogales , L. Worona-Dibner , S.J. Fernández-Ortiz , L. Rodriguez , C. DiLorenzo , J.A. Chávez-Barrera , P.S. Goday , S. Díaz-Madero , J.A. Ramírez-Mayans , C. Zubiri , J. Fernández-Sobreira , K.A. Santos-Jasso
Chronic constipation is a common condition seen in pediatrics. In recent years, new diagnostic and treatment measures have been applied, motivating the Asociación Mexicana de Gastroenterología to bring together a panel of national and international experts, for the aim of unifying concepts, providing recommendations on the use of complementary studies, and proposing the most appropriate treatment. A systematic search of the literature in English and Spanish was carried out for each statement formulated, utilizing Medline/PubMed, Cochrane Database, EMBASE (Ovid), and LILACS. The Delphi method was used for developing the consensus. Ten questions and 43 statements were discussed, establishing a recommendation grade and evaluating the quality of evidence. Different concepts, diagnostic methods, and pharmacologic and surgical therapeutic measures were discussed, and following three voting rounds, the recommendations based on current clinical evidence were established.
慢性便秘是儿科常见的情况。近年来，新的诊断和治疗措施得到了应用，促使Asociación Mexicana de Gastroenterología汇集了一个由国内和国际专家组成的小组，目的是统一概念，提供关于使用补充研究的建议，并提出最合适的治疗方法。利用Medline/PubMed、Cochrane数据库、EMBASE （Ovid）和LILACS，对每条表述进行了系统的英文和西班牙文文献检索。采用德尔菲法形成共识。讨论了10个问题和43个陈述，建立了推荐等级并评估了证据质量。讨论了不同的概念、诊断方法、药理学和外科治疗措施，并经过三轮投票，建立了基于当前临床证据的建议。
{"title":"Mexican consensus on the diagnosis and treatment of constipation in the pediatric population","authors":"R. Figueroa-Salazar , M.A. Ruíz-Castillo , E.M. Toro-Monjaraz , L. Casas-Guzik , R. Peña-Vélez , D.V. Bacarreza-Nogales , L. Worona-Dibner , S.J. Fernández-Ortiz , L. Rodriguez , C. DiLorenzo , J.A. Chávez-Barrera , P.S. Goday , S. Díaz-Madero , J.A. Ramírez-Mayans , C. Zubiri , J. Fernández-Sobreira , K.A. Santos-Jasso","doi":"10.1016/j.rgmxen.2025.10.024","DOIUrl":"10.1016/j.rgmxen.2025.10.024","url":null,"abstract":"<div><div>Chronic constipation is a common condition seen in pediatrics. In recent years, new diagnostic and treatment measures have been applied, motivating the <em>Asociación Mexicana de Gastroenterología</em> to bring together a panel of national and international experts, for the aim of unifying concepts, providing recommendations on the use of complementary studies, and proposing the most appropriate treatment. A systematic search of the literature in English and Spanish was carried out for each statement formulated, utilizing Medline/PubMed, Cochrane Database, EMBASE (Ovid), and LILACS. The Delphi method was used for developing the consensus. Ten questions and 43 statements were discussed, establishing a recommendation grade and evaluating the quality of evidence. Different concepts, diagnostic methods, and pharmacologic and surgical therapeutic measures were discussed, and following three voting rounds, the recommendations based on current clinical evidence were established.</div></div>","PeriodicalId":74705,"journal":{"name":"Revista de gastroenterologia de Mexico (English)","volume":"90 4","pages":"Pages 577-593"},"PeriodicalIF":0.0,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145508559","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-10-01DOI: 10.1016/j.rgmxen.2025.10.004
C. Ávalos-Camacho , K. Esparza-Ocampo , W. Gastelum-Espinoza , A. Guadrón-Llanos , S.V. Aguayo-Patrón , V. Picos-Cárdenas , L. Calderón Zamora , G. Duarte de la Peña , A.M. Calderón de la Barca , J. Magaña-Gómez
Introduction and aim
Celiac disease (CD) is an autoimmune enteropathy triggered by ingested gluten, with intra- and extra-gastrointestinal symptoms. Individuals with Down syndrome (DS) have a higher prevalence of autoimmune disorders, including CD. This study aimed to evaluate genetic predisposition (HLA haplotypes) and serological markers of CD in individuals with DS, from Northwestern Mexico.
Methods
Eighty-six participants with DS, 3–64 years of age, were included in the study. We assessed HLA-DQ2 and DQ8 haplotypes by duplex PCR and related symptoms, as well as IgG and IgA anti-gliadin antibodies, and IgA anti-tissue transglutaminase antibodies by an enzymatic immunoassay.
Results
Most participants (98.8%) carried risk alleles, with 52.9% having HLA-DQ2 and 45.9% HLA-DQ8. IgG anti-gliadin antibodies were positive in 8.1% of participants. In comparison, 6.9% were positive for IgA anti-gliadin antibodies, and 9.3% had a positive index for IgA anti-tissue transglutaminase antibodies. Four participants (4.6%) presented full or partial HLA-DQ2/DQ8 haplotypes, positive indexes for IgA anti-gliadin, and anti-transglutaminase antibodies related to CD.
Conclusions
The study reveals an almost complete genetic predisposition to autoimmunity and a very high risk of CD in individuals with DS. Enhanced diagnostic protocols and ongoing monitoring are recommended to improve the management of CD in this vulnerable population.
{"title":"Genetic predisposition to celiac disease in persons with Down syndrome in Northwestern Mexico","authors":"C. Ávalos-Camacho , K. Esparza-Ocampo , W. Gastelum-Espinoza , A. Guadrón-Llanos , S.V. Aguayo-Patrón , V. Picos-Cárdenas , L. Calderón Zamora , G. Duarte de la Peña , A.M. Calderón de la Barca , J. Magaña-Gómez","doi":"10.1016/j.rgmxen.2025.10.004","DOIUrl":"10.1016/j.rgmxen.2025.10.004","url":null,"abstract":"<div><h3>Introduction and aim</h3><div>Celiac disease (CD) is an autoimmune enteropathy triggered by ingested gluten, with intra- and extra-gastrointestinal symptoms. Individuals with Down syndrome (DS) have a higher prevalence of autoimmune disorders, including CD. This study aimed to evaluate genetic predisposition (HLA haplotypes) and serological markers of CD in individuals with DS, from Northwestern Mexico.</div></div><div><h3>Methods</h3><div>Eighty-six participants with DS, 3–64 years of age, were included in the study. We assessed HLA-DQ2 and DQ8 haplotypes by duplex PCR and related symptoms, as well as IgG and IgA anti-gliadin antibodies, and IgA anti-tissue transglutaminase antibodies by an enzymatic immunoassay.</div></div><div><h3>Results</h3><div>Most participants (98.8%) carried risk alleles, with 52.9% having HLA-DQ2 and 45.9% HLA-DQ8. IgG anti-gliadin antibodies were positive in 8.1% of participants. In comparison, 6.9% were positive for IgA anti-gliadin antibodies, and 9.3% had a positive index for IgA anti-tissue transglutaminase antibodies. Four participants (4.6%) presented full or partial HLA-DQ2/DQ8 haplotypes, positive indexes for IgA anti-gliadin, and anti-transglutaminase antibodies related to CD.</div></div><div><h3>Conclusions</h3><div>The study reveals an almost complete genetic predisposition to autoimmunity and a very high risk of CD in individuals with DS. Enhanced diagnostic protocols and ongoing monitoring are recommended to improve the management of CD in this vulnerable population.</div></div>","PeriodicalId":74705,"journal":{"name":"Revista de gastroenterologia de Mexico (English)","volume":"90 4","pages":"Pages 569-576"},"PeriodicalIF":0.0,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145395760","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-10-01DOI: 10.1016/j.rgmxen.2025.10.021
J.A. Teco-Cortes , P. Gómez-Cisneros , G.B. Aristi-Urista
Hepatocellular carcinoma is the most frequent primary malignant tumor of the liver. In Mexico, it is one of the main causes of death. It tends to be detected at late stages of the disease, making its prognosis poor in most cases. It has a wide range of clinical presentation and histologic subtypes, which can also have prognostic implications. We conducted an autopsy study series, in which we identified a total of 34 cases of hepatocellular carcinoma over a 6-year period, accounting for 1.37% of all the postmortem studies. The disease was slightly more frequent in men, with a 1.42:1 ratio, and in the sixth decade of life. The conventional subtype was more frequent, and the main cause of death was hypovolemic shock due to gastrointestinal bleeding. A striking datum was that only 38.2% of the cases were diagnosed before the autopsy report, underlining the need to improve protocols for the early detection of hepatocellular carcinoma.
{"title":"Hepatocellular carcinoma, an underdiagnosed entity: An autopsy series","authors":"J.A. Teco-Cortes , P. Gómez-Cisneros , G.B. Aristi-Urista","doi":"10.1016/j.rgmxen.2025.10.021","DOIUrl":"10.1016/j.rgmxen.2025.10.021","url":null,"abstract":"<div><div>Hepatocellular carcinoma is the most frequent primary malignant tumor of the liver. In Mexico, it is one of the main causes of death. It tends to be detected at late stages of the disease, making its prognosis poor in most cases. It has a wide range of clinical presentation and histologic subtypes, which can also have prognostic implications. We conducted an autopsy study series, in which we identified a total of 34 cases of hepatocellular carcinoma over a 6-year period, accounting for 1.37% of all the postmortem studies. The disease was slightly more frequent in men, with a 1.42:1 ratio, and in the sixth decade of life. The conventional subtype was more frequent, and the main cause of death was hypovolemic shock due to gastrointestinal bleeding. A striking datum was that only 38.2% of the cases were diagnosed before the autopsy report, underlining the need to improve protocols for the early detection of hepatocellular carcinoma.</div></div>","PeriodicalId":74705,"journal":{"name":"Revista de gastroenterologia de Mexico (English)","volume":"90 4","pages":"Pages 623-626"},"PeriodicalIF":0.0,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145472598","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-10-01DOI: 10.1016/j.rgmxen.2025.10.032
G. Mendoza-Domínguez , Z.M. Garrido-Santos , C. Lau , R. Balbuena , A.D. Santana-Vargas , M. Schmulson-Wasserman
{"title":"Response to Rattanapitoon et al., “Serum 7αC4 as a pragmatic diagnostic tool for bile acid malabsorption in Mexico: Implications and future directions”","authors":"G. Mendoza-Domínguez , Z.M. Garrido-Santos , C. Lau , R. Balbuena , A.D. Santana-Vargas , M. Schmulson-Wasserman","doi":"10.1016/j.rgmxen.2025.10.032","DOIUrl":"10.1016/j.rgmxen.2025.10.032","url":null,"abstract":"","PeriodicalId":74705,"journal":{"name":"Revista de gastroenterologia de Mexico (English)","volume":"90 4","pages":"Pages 641-643"},"PeriodicalIF":0.0,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145477290","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-10-01DOI: 10.1016/j.rgmxen.2025.10.006
M. Hernández Rodríguez, A. Figueroa Tubío, A. López Jérez
{"title":"Primary follicular lymphoma of the duodenum: Incidental finding in a routine gastroscopy","authors":"M. Hernández Rodríguez, A. Figueroa Tubío, A. López Jérez","doi":"10.1016/j.rgmxen.2025.10.006","DOIUrl":"10.1016/j.rgmxen.2025.10.006","url":null,"abstract":"","PeriodicalId":74705,"journal":{"name":"Revista de gastroenterologia de Mexico (English)","volume":"90 4","pages":"Pages 596-597"},"PeriodicalIF":0.0,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145373477","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Neuroendocrine tumor in the cecum: An unusual cause of chronic diarrhea in a young adult","authors":"D.A. Calle-Rodas , M.A. Corral-Cazorla , P.D. Muñoz-Espinoza , C.A. Machuca-Carpio , J.D. Cordero-García","doi":"10.1016/j.rgmxen.2025.10.009","DOIUrl":"10.1016/j.rgmxen.2025.10.009","url":null,"abstract":"","PeriodicalId":74705,"journal":{"name":"Revista de gastroenterologia de Mexico (English)","volume":"90 4","pages":"Pages 612-615"},"PeriodicalIF":0.0,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145395752","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-10-01DOI: 10.1016/j.rgmxen.2025.10.005
P. Huerta , J.P. Arab , L.A. Díaz
{"title":"Alcohol use and cirrhosis in women: An underestimated risk","authors":"P. Huerta , J.P. Arab , L.A. Díaz","doi":"10.1016/j.rgmxen.2025.10.005","DOIUrl":"10.1016/j.rgmxen.2025.10.005","url":null,"abstract":"","PeriodicalId":74705,"journal":{"name":"Revista de gastroenterologia de Mexico (English)","volume":"90 4","pages":"Pages 509-511"},"PeriodicalIF":0.0,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145395746","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-10-01DOI: 10.1016/j.rgmxen.2025.10.017
F.J. Valentín-Cortez , C.S. Silva-Ramos , C.F. Ortiz-Hidalgo , J. Lizardi-Montaño , J. Lizardi-Cervera
{"title":"Epstein-Barr virus as a cause of rectal ulcers in an immunosuppressed patient: A case report","authors":"F.J. Valentín-Cortez , C.S. Silva-Ramos , C.F. Ortiz-Hidalgo , J. Lizardi-Montaño , J. Lizardi-Cervera","doi":"10.1016/j.rgmxen.2025.10.017","DOIUrl":"10.1016/j.rgmxen.2025.10.017","url":null,"abstract":"","PeriodicalId":74705,"journal":{"name":"Revista de gastroenterologia de Mexico (English)","volume":"90 4","pages":"Pages 617-620"},"PeriodicalIF":0.0,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145433218","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-07-01DOI: 10.1016/j.rgmxen.2025.09.008
D. Aguirre-Villarreal , L. Rosales-Rentería , I. García-Juárez , A. Rosales-Padrón , F. Manzo-Santana
Cirrhosis of the liver is a major cause of death worldwide, with a recent increase in cases secondary to metabolic dysfunction-associated steatotic liver disease and alcohol use. Liver transplantation is currently the only definitive treatment but requires immunosuppression for preventing graft rejection.
Calcineurin inhibitors are the cornerstone of immunosuppression in transplanted patients. However, their use conditions metabolic and renal complications, such as metabolic syndrome, post-transplant diabetes, and chronic kidney disease. Minimizing or discontinuing immunosuppression has been shown to reduce those adverse effects in selected patients, especially those with potential immunotolerance. Predictors of immunotolerance and cardiovascular complications in transplanted patients have been identified in recent studies. Thus, there is a need for developing individualized strategies for balancing metabolic risk and graft rejection prevention.
{"title":"Role of immunosuppression in liver transplantation. Advantages and disadvantages","authors":"D. Aguirre-Villarreal , L. Rosales-Rentería , I. García-Juárez , A. Rosales-Padrón , F. Manzo-Santana","doi":"10.1016/j.rgmxen.2025.09.008","DOIUrl":"10.1016/j.rgmxen.2025.09.008","url":null,"abstract":"<div><div>Cirrhosis of the liver is a major cause of death worldwide, with a recent increase in cases secondary to metabolic dysfunction-associated steatotic liver disease and alcohol use. Liver transplantation is currently the only definitive treatment but requires immunosuppression for preventing graft rejection.</div><div>Calcineurin inhibitors are the cornerstone of immunosuppression in transplanted patients. However, their use conditions metabolic and renal complications, such as metabolic syndrome, post-transplant diabetes, and chronic kidney disease. Minimizing or discontinuing immunosuppression has been shown to reduce those adverse effects in selected patients, especially those with potential immunotolerance. Predictors of immunotolerance and cardiovascular complications in transplanted patients have been identified in recent studies. Thus, there is a need for developing individualized strategies for balancing metabolic risk and graft rejection prevention.</div></div>","PeriodicalId":74705,"journal":{"name":"Revista de gastroenterologia de Mexico (English)","volume":"90 3","pages":"Pages 499-501"},"PeriodicalIF":0.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145042612","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-07-01DOI: 10.1016/j.rgmxen.2025.09.014
S.A. Chávez-Sánchez, L.E. Flores-Egocheaga
{"title":"Hemostatic clip use for the control of ulcer bleeding after esophageal variceal ligation","authors":"S.A. Chávez-Sánchez, L.E. Flores-Egocheaga","doi":"10.1016/j.rgmxen.2025.09.014","DOIUrl":"10.1016/j.rgmxen.2025.09.014","url":null,"abstract":"","PeriodicalId":74705,"journal":{"name":"Revista de gastroenterologia de Mexico (English)","volume":"90 3","pages":"Pages 483-485"},"PeriodicalIF":0.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145076855","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
扫码关注我们
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号