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Bridging Gaps in Medical Toxicology Expertise Via Instant-Messaging Technology: The Experience of Nepal's First Institution-based Poison Information Center. 通过即时通讯技术弥合医学毒理学专业知识的差距:尼泊尔第一个基于机构的毒物信息中心的经验。
Pub Date : 2025-09-02
Ramu Kharel, Pravin Prasad, Rakesh Ghimire, Rajesh Sharma, James D Whitledge, Joshua Bloom, Ziad Kazzi, Knut Erik Hovda
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引用次数: 0
Cognitive-Communication Rehabilitation after Brain Injuries. 脑损伤后认知-沟通康复。
Pub Date : 2025-08-01
Joan M Jordan, Jon A Mukand

Speech-language pathologists (SLPs) provide communicative and cognitive rehabilitation for people with brain injuries, and this article describes current assessment and treatment after a brain injury. Cognitive problems can affect attention, concentration, and memory, as well as metacognitive skills to self-monitor, control, and adjust one's thinking. Speech-language pathology (SLP) rehabilitation is initiated in acute inpatient settings and then through a continuum of inpatient rehabilitation, skilled nursing facility, home care, and outpatient settings. Speech-language pathology helps adults with brain injury return to work; sports-related concussion care is provided in school settings. SLPs use assessment tools with normative comparisons to determine severity levels and treatment plans. Patient-centered approaches are used for assessment and treatment plans, to identify specific functional needs that may direct the treatment towards specific functional outcomes.

语言病理学家(slp)为脑损伤患者提供沟通和认知康复,本文描述了目前脑损伤后的评估和治疗。认知问题会影响注意力、注意力和记忆力,以及自我监控、控制和调整思维的元认知技能。言语语言病理(SLP)康复始于急性住院环境,然后通过连续的住院康复、熟练护理设施、家庭护理和门诊环境。语言病理学帮助脑损伤的成年人重返工作岗位;在学校环境中提供与运动有关的脑震荡护理。slp使用具有规范性比较的评估工具来确定严重程度和治疗计划。以患者为中心的方法用于评估和治疗计划,以确定特定的功能需求,从而指导治疗达到特定的功能结果。
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引用次数: 0
Glioblastoma: Epidemiology and Imaging-Based Review. 胶质母细胞瘤:流行病学和影像学综述。
Pub Date : 2025-08-01
Joseph Madour, Justin Bessette, Joey Z Gu, Erika L Thayer, Heinrich Elinzano, Alessandra J Sax

Glioblastoma (GBM) is an aggressive brain tumor, commonly occurring in the frontal and temporal lobes. GBM is characterized by low survival rates, high recurrence rates, and unclear risk factors, making management a significant challenge. Anatomic magnetic resonance imaging (MRI), including T1-weighted, T2-weighted, and fluid-attenuated inversion recovery (FLAIR), is the gold standard for diagnosis of GBM. These techniques have lower accuracy in evaluating treatment response, as pseudoprogression and radionecrosis can mimic true tumor progression (TrTP). Advanced imaging options that offer physiologic information, such as diffusion- weighted imaging, MR perfusion, MR spectroscopy, and Positron Emission Tomography (PET), have shown promise in aiding diagnosis and treatment response monitoring. The first-line treatment for GBM is maximal safe neurosurgical resection, followed by adjuvant radiotherapy and temozolomide, an oral DNA alkylating agent. Current research is focused on optimizing imaging to evaluate TrTP and developing novel treatments to increase survival rates.

胶质母细胞瘤(GBM)是一种侵袭性脑肿瘤,常见于额叶和颞叶。GBM的特点是生存率低,复发率高,危险因素不明确,使治疗成为一项重大挑战。解剖磁共振成像(MRI),包括t1加权、t2加权和液体衰减反转恢复(FLAIR),是诊断GBM的金标准。这些技术在评估治疗反应方面准确性较低,因为假进展和放射性坏死可以模拟真正的肿瘤进展(TrTP)。提供生理信息的高级成像选择,如扩散加权成像、磁共振灌注、磁共振光谱和正电子发射断层扫描(PET),在帮助诊断和治疗反应监测方面显示出了希望。GBM的一线治疗是最大限度的安全神经外科切除,其次是辅助放疗和替莫唑胺(一种口服DNA烷基化剂)。目前的研究重点是优化成像来评估TrTP和开发新的治疗方法来提高生存率。
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引用次数: 0
Novel Patient Intake Survey for the Diagnosis and Management of Hip Osteoarthritis. 髋关节骨关节炎诊断和治疗的新型患者摄入调查。
Pub Date : 2025-08-01
Jonathan Liu, Tucker Callanan, Mohammad Daher, Noah Gilreath, Janine Molino, Thomas Barrett, Eric Cohen, Valentin Antoci

Introduction: Hip osteoarthritis (OA) is a common cause of hip pain in adults and a frequent presentation in primary care, emergency departments, and orthopedic clinics. To improve patient triage and optimize clinical efficiency, we developed a nine-item intake survey designed to assess patient symptoms and prior treatments. This study aimed to evaluate the survey's ability to differentiate hip OA from other hip pathologies and assess its correlation with treatment recommendations.

Methods: New patients presenting with hip pain were administered a nine-item multiple choice survey. Each response was assigned a score, and the total cumulative score was recorded. Diagnoses and treatment recommendations, including total hip arthroplasty (THA), were documented. Logistic regression was used to assess associations between the survey scores and both diagnosis and treatment recommendations. Receiver operating characteristic (ROC) analysis and Youden's J statistics were applied to determine the optimal survey score threshold for diagnosing hip OA.

Results: The survey effectively distinguished hip osteoarthritis from other hip pathologies based upon cumulative score. ROC analysis identified a total score of ≥9 as the optimal threshold, maximizing sensitivity (83.3%) and specificity (55.9%) for diagnosing hip OA. The positive predictive value for this threshold was 78.6%. Additionally, higher total survey scores were significantly associated with the recommendation for THA.

Conclusion: This study demonstrates that a simple nine-item, patient-reported survey can reliably differentiate hip OA from other hip conditions and may assist in guiding treatment decisions. Implementing such tools in primary care, emergency medicine, and orthopedic settings could enhance early diagnosis and streamline referrals.

Level of evidence: III.

髋关节骨关节炎(OA)是成人髋关节疼痛的常见原因,在初级保健、急诊科和骨科诊所经常出现。为了改善患者分诊和优化临床效率,我们制定了一项包含9个项目的摄入调查,旨在评估患者的症状和既往治疗。本研究旨在评估该调查区分髋关节OA与其他髋关节病变的能力,并评估其与治疗建议的相关性。方法:对新发髋关节疼痛患者进行9项选择问卷调查。每个回答被分配一个分数,并记录总累积分数。诊断和治疗建议,包括全髋关节置换术(THA),均被记录。使用逻辑回归来评估调查得分与诊断和治疗建议之间的关联。采用受试者工作特征(ROC)分析和Youden's J统计来确定诊断髋关节OA的最佳调查评分阈值。结果:基于累积评分,该调查有效地将髋关节骨关节炎与其他髋关节病变区分开来。ROC分析确定总分≥9为诊断髋关节OA的最佳阈值,最大程度地提高了敏感性(83.3%)和特异性(55.9%)。该阈值的阳性预测值为78.6%。此外,较高的调查总分与推荐THA显著相关。结论:本研究表明,一项简单的9项患者报告的调查可以可靠地区分髋关节OA与其他髋关节疾病,并有助于指导治疗决策。在初级保健、急诊医学和骨科环境中实施这些工具可以提高早期诊断和简化转诊。证据水平:III。
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引用次数: 0
Restoring Function After TBI: A Review of Physical Therapy Strategies for Balance, Gait, and Dual-Task Recovery. 脑外伤后功能恢复:平衡、步态和双任务恢复的物理治疗策略综述。
Pub Date : 2025-08-01
Kenneth Vinacco, Nicole Rawnsley, Elizabeth Kolator, Jon A Mukand

Individuals with moderate to severe traumatic brain injury (TBI) often experience impairments in balance, gait, and dual-task ability, limiting their functional independence and community reintegration. These deficits arise from disruptions across sensory, motor, and cognitive systems, requiring comprehensive physical therapy (PT) assessment and intervention. PT evaluations incorporate strength, coordination, and sensory integration measures using standardized outcome measures such as the Berg Balance Scale, Functional Gait Assessment, and dual-task assessments such as the Timed Up and Go (cognitive). Treatment strategies include high-intensity training, gait and balance training, and vestibular rehabilitation, each targeting specific deficits to promote neuroplasticity and recovery. Technological interventions like the LiteGait®, virtual reality, and the Bioness Integrated Therapy System enhance therapy outcomes by improving safety, cognition, and balance. PTs must address psychosocial barriers and collaborate across disciplines to support holistic recovery. Ongoing evaluation using outcome measures guides treatment progression and readiness for community reintegration, highlighting PT's critical role in restoring functional independence post-TBI.

中度至重度创伤性脑损伤(TBI)患者通常会出现平衡、步态和双任务能力障碍,限制了他们的功能独立性和重返社区。这些缺陷来自感觉、运动和认知系统的破坏,需要综合物理治疗(PT)评估和干预。PT评估包括力量、协调和感觉整合测量,使用标准化的结果测量,如伯格平衡量表、功能步态评估和双任务评估,如定时起身和行走(认知)。治疗策略包括高强度训练、步态和平衡训练以及前庭康复,每一种都针对特定的缺陷,以促进神经的可塑性和恢复。像LiteGait®、虚拟现实和Bioness综合治疗系统这样的技术干预通过改善安全性、认知和平衡来提高治疗效果。pt必须解决心理障碍,并跨学科合作,以支持整体康复。正在进行的评估使用的结果措施指导治疗进展和社区重返社会的准备,强调PT在恢复功能独立后tbi的关键作用。
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引用次数: 0
Current Concepts in Neurogenic Heterotopic Ossification. 神经源性异位骨化的最新概念。
Pub Date : 2025-08-01
Jonathan Liu, Noah Gilreath, Sydney Rozenfeld, Sandi Caus, Sarah Criddle, Edward J Testa, Andrew Evans

Heterotopic ossification (HO) is abnormal bone deposition, most commonly in the hip or elbow, that can significantly impair patients due to pain, stiffness, and contractures, which prevents them from carrying out activities of daily living. A traumatic brain (TBI) or spinal cord injury may prompt the formation of heterotopic ossification, creating so-called neurogenic heterotopic ossification (NHO). The pathophysiology of this condition is not fully understood, but probably involves a complex interplay between a biological scaffold of demineralized bone, CNS signaling, and local tissue signal mediators that often result from trauma. This environment is conducive to HO formation. Diagnosis relies on laboratory testing, plain radiographs, and advanced imaging such as triple phase bone scan or computed tomography scan. Treatment involves medical management with anti-inflammatory drugs, bisphosphonates, radiation therapy, or surgical excision, although outcomes are variable both in regards to prevention and treatment. A mainstay of treatment is physical therapy to maintain range of motion. This paper also presents a case study of a poly-traumatized patient with a TBI and multi-level spinal column injury who developed NHO after acetabular fixation.

异位骨化(HO)是一种异常骨沉积,最常见于髋部或肘部,可因疼痛、僵硬和挛缩而严重损害患者,使患者无法进行日常生活活动。创伤性脑(TBI)或脊髓损伤可促进异位骨化的形成,形成所谓的神经源性异位骨化(NHO)。这种情况的病理生理学尚不完全清楚,但可能涉及脱矿骨的生物支架、中枢神经系统信号和局部组织信号介质之间复杂的相互作用,这些介质通常由创伤引起。这种环境有利于HO的形成。诊断依赖于实验室测试,x线平片和高级成像,如三期骨扫描或计算机断层扫描。治疗包括抗炎药物、双膦酸盐、放射治疗或手术切除,尽管在预防和治疗方面的结果是可变的。主要的治疗方法是物理治疗,以保持活动范围。本文还介绍了一例多创伤性脑外伤和多级别脊柱损伤患者在髋臼固定后发生NHO的病例研究。
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引用次数: 0
Common Sequelae of Severe Traumatic Brain Injury: A Case Report. 重型颅脑外伤常见后遗症1例。
Pub Date : 2025-08-01
Stephan P Pirnie

Severe traumatic brain injuries (TBI) are caused by external forces that damage brain tissue and result in prolonged cognitive, sensory and motor deficits. This case report highlights the neurocognitive, motor, and sensory results of severe traumatic brain injury as well as several sequelae that often complicate TBI.

严重创伤性脑损伤(TBI)是由外力损伤脑组织引起的,并导致长期的认知、感觉和运动缺陷。本病例报告强调了严重外伤性脑损伤的神经认知、运动和感觉结果,以及一些经常使TBI复杂化的后遗症。
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引用次数: 0
An Orthopedic Perspective on the Management of Spasticity. 痉挛治疗的骨科观点。
Pub Date : 2025-08-01
Mary Lou, Ashley Knebel, Jacob Eberson, Craig P Eberson

Neurologic conditions such as brain injuries, cerebral palsy, stroke and multiple sclerosis involve injury of upper motor neurons, which can manifest as spasticity. The resulting hypertonicity and imbalance of forces between muscle groups leads to deformities that impair patient function and can cause significant long-term complications. Symptoms of spasticity can be managed with nonoperative techniques such as physiotherapy, bracing, or medications. Other approaches such as intrathecal baclofen pumps and selective dorsal rhizotomy have also demonstrated efficacy in controlling spasticity. Spasticity that has failed nonoperative management can be treated with orthopedic surgeries that correct deformities by either restoring joint anatomy or re-balancing the forces of spastic muscle groups. Improved mobility and reduced pain after these procedures can help patients with their rehabilitation, function, and independence.

神经系统疾病,如脑损伤、脑瘫、中风和多发性硬化症,涉及上运动神经元的损伤,可表现为痉挛。由此产生的高张力和肌肉群之间的力量不平衡导致畸形,损害患者的功能,并可能导致严重的长期并发症。痉挛症状可以通过非手术技术,如物理治疗、支具或药物治疗来控制。其他方法如鞘内巴氯芬泵和选择性背根切断术也被证明对控制痉挛有效。非手术治疗失败的痉挛可以通过矫形手术来治疗,通过恢复关节解剖或重新平衡痉挛肌群的力量来纠正畸形。手术后活动能力的改善和疼痛的减轻有助于患者的康复、功能和独立性。
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引用次数: 0
Evaluation of the Mental Health Temperature of Rhode Island Emergency Medical Services (EMS). 罗德岛州紧急医疗服务中心(EMS)心理健康温度评估
Pub Date : 2025-08-01
Katelin M Ferreira, Megan Umbriano, Eric Rossmeisl, Jason M Rhodes, Kenneth A Williams

Mental health among first responders is often impacted by repeated exposure to stressors and traumatic events. As a result, Emergency Medical Services (EMS) professionals have a higher risk of suicide than the general public.1 With each state having different EMS cultures and operations, the Rhode Island Department of Health (RIDOH) Center for EMS identified a need to assess the mental health of EMS professionals in Rhode Island. A survey was distributed to EMS professionals in Rhode Island to evaluate their mental health and identify demographic gaps, as well as assess the risk of suicide for EMS professionals. Survey results provided evidence of concerning mental health among first responders in Rhode Island, with 15.4 percent of responders reporting suicidal ideation in the past 12 months. The results suggest that increased programming to provide resources and awareness is necessary to improve mental health and ensure the longevity of EMS professionals' careers.

急救人员的心理健康经常受到反复暴露于压力源和创伤性事件的影响。因此,紧急医疗服务(EMS)专业人员比一般公众有更高的自杀风险由于每个州都有不同的急救文化和运作方式,罗德岛州卫生部(RIDOH)急救中心确定有必要评估罗德岛州急救专业人员的心理健康。向罗德岛州的急救专业人员分发了一项调查,以评估他们的心理健康状况,确定人口差距,并评估急救专业人员的自杀风险。调查结果提供了罗德岛州第一响应者有关心理健康的证据,15.4%的响应者在过去12个月中报告了自杀念头。结果表明,有必要增加规划,提供资源和意识,以改善心理健康,确保EMS专业人员的职业生涯长寿。
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引用次数: 0
Management of Benign Symptomatic Thyroid Nodules in Rhode Island Using Radiofrequency Ablation. 罗德岛使用射频消融术治疗良性症状性甲状腺结节。
Pub Date : 2025-07-01
Nina S Li, Sonia Giyanani, DaeHee Kim, Steve Kwon, John Lee

The management of benign symptomatic thyroid nodules can pose a challenge when weighing treatment options. While surgical resection has been the gold standard, the risks and consequences of partial or total thyroidectomy may outweigh the benefits of the procedure. Additionally, a significant number of patients are not surgical candidates due to comorbidities, potential risks, or personal preference. Radiofrequency ablation (RFA) has emerged as a minimally invasive, low-risk alternative to traditional surgery, and it has demonstrated to have high efficacy in nodule volume reduction, symptom resolution, and cosmetic improvement. Hence, the use of RFA for treatment of benign thyroid nodules has been supported by both international and national professional groups. This paper hopes to promote the use of RFA for treatment of benign solid thyroid nodules in the Rhode Island population as well as outline its potential clinical application.

当权衡治疗方案时,良性症状甲状腺结节的管理可能会带来挑战。虽然手术切除一直是金标准,但部分或全部甲状腺切除术的风险和后果可能超过手术的好处。此外,由于合并症、潜在风险或个人偏好,大量患者不适合手术。射频消融(RFA)已成为传统手术的一种微创、低风险替代方法,并已被证明在减少结节体积、缓解症状和改善外观方面具有很高的疗效。因此,使用射频消融治疗良性甲状腺结节得到了国际和国内专业团体的支持。本文希望促进RFA在罗德岛人群中治疗良性实性甲状腺结节的应用,并概述其潜在的临床应用。
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引用次数: 0
期刊
Rhode Island medical journal (2013)
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