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Diagnostic Feasibility and Accuracy of Cardiac Positron Emission Tomography (PET) in the Evaluation of Ischemic Heart Disease. 心脏正电子发射断层扫描(PET)诊断缺血性心脏病的可行性和准确性。
Pub Date : 2025-02-03
Yasmeen Mohammad, Muhammad Baig, Brian G Abbott, Edward Hulten

Cardiac Positron Emission Tomography (PET) can be used for the assessment of myocardial perfusion. Compared to other cardiac imaging techniques, notably Single Photon Emission Computer Tomography (SPECT), cardiac PET offers superior image resolution, higher accuracy, quantitative measures of myocardial perfusion, lower radiation exposure, and shorter image acquisition time. However, PET tends to be costlier and less widely available than SPECT due to the specialized equipment needed for generating the necessary radiotracers. Despite these challenges, PET has emerged as the preferred imaging modality for evaluating coronary artery disease due to its exceptional accuracy and broad applicability. Enhancing access to PET is anticipated to significantly improve the diagnosis and treatment of patients with cardiac conditions that might otherwise remain inadequately assessed.

心脏正电子发射断层扫描(PET)可用于评估心肌灌注。与其他心脏成像技术相比,特别是单光子发射计算机断层扫描(SPECT),心脏PET具有更好的图像分辨率,更高的准确性,定量测量心肌灌注,更低的辐射暴露和更短的图像采集时间。然而,由于产生必要的放射性示踪剂需要专门的设备,PET往往比SPECT更昂贵,更不容易获得。尽管存在这些挑战,PET由于其卓越的准确性和广泛的适用性,已成为评估冠状动脉疾病的首选成像方式。增强PET的可及性有望显著改善心脏病患者的诊断和治疗,否则这些患者可能仍未得到充分评估。
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引用次数: 0
Update in Cardiovascular Prevention: From Risk Scores to Imaging. 心血管预防最新进展:从风险评分到影像学。
Pub Date : 2025-02-03
Thomas Nubong, Chan Woo Kim, Vishal Khetpal, Edward Hulten, Verity Ramirez

Atherosclerotic cardiovascular disease (ASCVD) remains the leading cause of morbidity and mortality worldwide. This review explores the evolving evidence base surrounding ASCVD prevention, particularly regarding nontraditional biomarkers, risk scores, and cardiovascular imaging modalities. Additionally, this review examines cardiovascular risk scores, including the PREVENT and MESA-CHD scores, which incorporate both traditional and nontraditional factors, thereby aspiring to offer a more equitable and precise risk assessment. Advances in cardiovascular imaging techniques, such as coronary artery calcium scoring and cardiac magnetic resonance imaging, are also discussed for their utility and potential. By integrating these advanced markers and imaging modalities, primary care clinicians can better identify and manage patients at risk, ultimately improving outcomes and reducing the burden of cardiovascular disease.

动脉粥样硬化性心血管疾病(ASCVD)仍然是世界范围内发病率和死亡率的主要原因。这篇综述探讨了围绕ASCVD预防的不断发展的证据基础,特别是关于非传统的生物标志物、风险评分和心血管成像方式。此外,本综述还研究了心血管风险评分,包括预防和MESA-CHD评分,这些评分结合了传统和非传统因素,从而希望提供更公平和准确的风险评估。心血管成像技术的进展,如冠状动脉钙评分和心脏磁共振成像,也讨论了他们的效用和潜力。通过整合这些先进的标志物和成像模式,初级保健临床医生可以更好地识别和管理有风险的患者,最终改善预后并减轻心血管疾病的负担。
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引用次数: 0
Delayed-Onset Isolated ICI (pembrolizumab)-Associated Gastritis with Concomitant Intussusception. 伴有肠套叠的迟发性孤立 ICI(pembrolizumab)相关性胃炎
Pub Date : 2024-12-02
Casey Reed, Yousef Elfanagely, May Min

Immune checkpoint inhibitors are increasingly used in the treatment of a number of malignancies and carry a known risk of immune-related adverse events (irAEs). IrAEs cover a broad range of affected organ systems and presenting symptoms. While the gastrointestinal system is a commonly affected system, isolated gastritis is an uncommon diagnosis. We present a patient with isolated ICI-related gastritis presenting with concomitant intussusception caused by the anti-programmed cell death-1 antibody, pembrolizumab.

免疫检查点抑制剂越来越多地用于治疗多种恶性肿瘤,但已知其具有发生免疫相关不良事件(irAEs)的风险。IrAEs涉及多种受影响的器官系统和症状。虽然胃肠道系统是常见的受影响系统,但孤立性胃炎的诊断并不常见。我们介绍了一名因服用抗程序性细胞死亡-1 抗体--pembrolizumab 而引起的孤立性 ICI 相关性胃炎并发肠套叠的患者。
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引用次数: 0
The Importance of Language and Messaging in Psychological Treatment for Functional Neurological Disorder in Children and Adolescents. 语言和信息传递在儿童和青少年功能性神经紊乱心理治疗中的重要性。
Pub Date : 2024-11-01
Rebecca Laptook

The treatment for Functional Neurological Disorder (FND) is complex and often includes a multidisciplinary approach. One core intervention is the psychological approach through therapy, typically drawing on evidence-based practices and incorporating biopsychosocial themes. This article highlights components of the psychological approach that are integral to treatment. While therapeutic concepts are explained in the context of treatment at the Hasbro Children's Partial Hospital Program, they are applicable to any setting. This article will review the importance of psychoeducation and the importance of language and messaging when talking with patients and families. Additionally, key concepts of emotional expression and distress tolerance, which are central to psychological treatment, are discussed. Finally, this article highlights the role of the family and the integral part it plays in the treatment for FND.

功能性神经失调症(FND)的治疗非常复杂,通常包括多学科方法。其中一项核心干预措施是通过治疗进行心理治疗,通常借鉴循证实践并结合生物心理社会主题。本文重点介绍了心理治疗方法中不可或缺的组成部分。虽然治疗概念是在孩之宝儿童部分住院计划的治疗背景下解释的,但它们适用于任何环境。本文将回顾心理教育的重要性,以及与患者和家属交谈时语言和信息传递的重要性。此外,本文还将讨论情绪表达和痛苦耐受的关键概念,这些概念是心理治疗的核心。最后,本文将强调家庭的作用及其在 FND 治疗中不可或缺的角色。
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引用次数: 0
Functional Neurological Disorder in Pediatrics: Diagnostic Considerations. 儿科功能性神经紊乱:诊断注意事项。
Pub Date : 2024-11-01
Haley Moulton, Diane DerMarderosian, Heather A Chapman

Functional neurological disorder (FND) is a common diagnosis of varied neuropsychiatric symptoms presenting to pediatric healthcare settings, including primary, urgent and subspecialty care. A key diagnostic shift appearing in the DSM-V is that FND is no longer a diagnosis of exclusion; rather, a rule-in diagnosis based on suggestive elements of symptom presentation. This article reviews diagnostic criteria, clarifying features, risks, and prognostic factors. This is the first in a series of six articles on FND and will introduce an FND case that will be examined in each subsequent article in the context of their more specific subject matter.

功能性神经紊乱(FND)是儿科医疗机构(包括初级、急诊和亚专科医疗机构)常见的诊断方法,表现为各种神经精神症状。DSM-V 中出现的一个重要诊断转变是,FND 不再是一种排除性诊断,而是一种基于症状表现的提示性诊断。本文回顾了诊断标准,阐明了特征、风险和预后因素。本文是关于 FND 的六篇系列文章中的第一篇,将介绍一个 FND 病例,随后的每篇文章将结合更具体的主题对该病例进行研究。
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引用次数: 0
The Rehabilitation Therapist's Role in the Treatment of Functional Neurological Disorder in Children and Adolescents. 康复治疗师在治疗儿童和青少年功能性神经紊乱中的作用。
Pub Date : 2024-11-01
Jessica Gore, Kayla Petitpas, Christopher McCormick, Heather A Chapman

Functional Neurological Disorder (FND) is a common condition encountered by rehabilitation therapists (physical therapists-PT, occupational therapists-OT, and speech and language pathologists-SLP) in pediatric practice. In an effort to bridge the knowledge and experience gap, PT, OT and SLP experts have published consensus recommendations for the rehab therapist's treatment of FND1-3 with additional research emphasizing a psychologically informed4,5 and wellness approach.6 This article highlights the unique role of each rehab discipline in treating FND, reviews functional diagnoses specific to PT, OT and SLP, and introduces a unique stepwise or ladder approach to treatment that can be utilized in the inpatient or outpatient setting.

功能性神经紊乱(FND)是康复治疗师(物理治疗师-PT、作业治疗师-OT 和言语及语言病理学家-SLP)在儿科临床实践中遇到的一种常见疾病。为了弥补知识和经验上的差距,物理治疗师、作业治疗师和语言病理学家专家发表了康复治疗师治疗 FND 的共识建议1-3,并有更多的研究强调了心理知情4,5 和健康方法6。本文强调了各康复学科在治疗 FND 中的独特作用,回顾了物理治疗师、作业治疗师和语言病理学家的特定功能诊断,并介绍了一种可在住院或门诊环境中使用的独特阶梯式治疗方法。
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引用次数: 0
Supporting Children and Adolescents with Functional Neurological Disorder in the School Setting. 在学校环境中为患有功能性神经障碍症的儿童和青少年提供支持。
Pub Date : 2024-11-01
Kelsey Borner, Rebecca Laptook

Functional Neurological Disorder (FND) can significantly impact school functioning. Symptoms may affect children and adolescents academically, socially, psychologically, and impact school attendance. This article reviews the importance of being able to continue in school despite FND symptoms and recommendations to support this. It will provide a guideline for communication and collaboration with schools and describe the type of information that is helpful to share with school teams. This article will also discuss various accommodations that can be helpful in the school setting. Finally, other resources, such as IEPs and 504 Plans as well as additional sources of information and support are briefly reviewed.

功能性神经紊乱(FND)会严重影响学校功能。这些症状可能会影响儿童和青少年的学业、社交和心理,并影响学校出勤率。本文回顾了在出现 FND 症状的情况下仍能继续上学的重要性,并提出了相关建议。文章将为与学校的沟通和合作提供指导,并介绍有助于与学校团队分享的信息类型。本文还将讨论在学校环境中可能有帮助的各种适应措施。最后,还将简要回顾其他资源,如个人教育计划和 504 计划以及其他信息和支持来源。
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引用次数: 0
COBRE Center for Stress, Trauma, and Resilience (STAR COBRE): A Regional and National Hub for Transformative Research to Elucidate and Mitigate the Lasting Imprint of Early Stress and Trauma. COBRE 压力、创伤和复原力中心(STAR COBRE):地区和国家转型研究中心,旨在阐明和减轻早期压力和创伤的持久影响。
Pub Date : 2024-11-01
Milagros Grados, Chrystal Vergara-Lopez, Beth C Bock, Nicole R Nugent, Stephanie H Parade, Audrey R Tyrka, Laura R Stroud

Early adversity is a major contributor to psychiatric conditions and poor physical health that burden individuals and groups across Rhode Island, the United States, and globally. We established a Center of Biomedical Research Excellence (COBRE) for Stress, Trauma, and Resilience (STAR) at The Miriam Hospital to identify mechanisms linking early adversity and health, to curtail detrimental consequences of stress and trauma, and promote resilience. The STAR COBRE is a vibrant regional and national hub for transformative research to elucidate and mitigate the lasting imprint of stress and trauma across the lifespan. We have a focus on reducing health inequities among historically marginalized families including those living in poverty and from underrepresented racial and ethnic communities. A cornerstone of the STAR COBRE is fostering an inclusive community to support the advancement of a diverse group of early career researchers to emerge as leading independent investigators conducting cutting-edge STAR research.

早期逆境是导致精神疾病和身体健康状况不佳的主要因素,给罗德岛、美国乃至全球的个人和群体造成了负担。我们在米里亚姆医院建立了压力、创伤和复原力(STAR)生物医学卓越研究中心(COBRE),以确定早期逆境与健康之间的关联机制,减少压力和创伤的有害后果,提高复原力。STAR COBRE 是一个充满活力的地区性和全国性变革性研究中心,旨在阐明和减轻压力和创伤对整个生命周期造成的持久影响。我们的工作重点是减少历史上被边缘化的家庭(包括贫困家庭和代表性不足的种族和民族社区)在健康方面的不公平现象。STAR COBRE 的基石是培养一个包容性的社区,以支持多样化的早期职业研究人员的发展,使他们成为开展尖端 STAR 研究的主要独立研究人员。
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引用次数: 0
Skull and Soft Tissue Syphilis: 15-year-old with Scalp and Skin Lesions. 颅骨和软组织梅毒:头皮和皮肤病变的15岁少年
Pub Date : 2024-10-01
Thaddeus Wright, Osama Ibrahim, Elena Puscasiu, Glenn A Tung, Sabina Holland
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引用次数: 0
Newborn and Birthing Parent Characteristics of Neonatal Abstinence Syndrome Cases in Rhode Island, 2020-2023. 2020-2023 年罗德岛新生儿禁欲综合症病例的新生儿和分娩父母特征。
Pub Date : 2024-10-01
Kristen St John, William Arias
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引用次数: 0
期刊
Rhode Island medical journal (2013)
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