首页 > 最新文献

Schizophrenia (Heidelberg, Germany)最新文献

英文 中文
Elevated serum kynurenic acid in individuals with first-episode psychosis and insufficient response to antipsychotics. 首发精神病患者血清犬尿酸升高且对抗抑郁药反应不足。
IF 3 Q2 PSYCHIATRY Pub Date : 2024-07-10 DOI: 10.1038/s41537-024-00483-z
Alex Hatzimanolis, Stefania Foteli, Lida-Alkisti Xenaki, Mirjana Selakovic, Stefanos Dimitrakopoulos, Ilias Vlachos, Ioannis Kosteletos, Rigas-Filippos Soldatos, Maria Gazouli, Stylianos Chatzipanagiotou, Nikos Stefanis

The tryptophan-metabolizing kynurenine pathway (KP) can be activated by enhanced inflammatory responses and has been implicated in the pathophysiology of schizophrenia. However, there is little evidence for KP dysregulation in the early course of psychotic illness. We aimed to investigate the potential immune-mediated hyperactivity of KP in individuals with first-episode psychosis (FEP) and the relationship with symptom severity and treatment response outcomes. Serum immunoassays were performed to measure peripheral levels of inflammatory cytokines (IL-1β, IL-10, TNF-a), KP rate-limiting enzymes (IDO/TDO), and kynurenic acid (KYNA) metabolite in 104 antipsychotic-naïve patients with FEP and 80 healthy controls (HC). The Positive and Negative Syndrome Scale (PANSS) and the Global Assessment of Functioning Scale (GAF) were administered to assess psychopathology and functioning status at admission and following 4-week treatment with antipsychotics. Cytokine and KP components levels were substantially increased in FEP patients compared to HC, before and after antipsychotic treatment. A significant positive correlation between pro-inflammatory IL-1β and KYNA levels was observed among FEP patients, but not in HC. Importantly, within-patient analysis revealed that those with higher baseline KYNA experienced more severe negative symptoms and poorer clinical improvement at follow-up. These findings suggest that KP is upregulated in early psychosis, likely through the induction of IL-1β-dependent pathways, and raised peripheral KYNA might represent a promising indicator of non-response to antipsychotic medication in patients with FEP.

色氨酸代谢犬尿氨酸途径(KP)可被增强的炎症反应激活,并被认为与精神分裂症的病理生理学有关。然而,几乎没有证据表明 KP 在精神疾病的早期病程中失调。我们旨在研究 KP 在首发精神病患者(FEP)中潜在的免疫介导的高活性以及与症状严重程度和治疗反应结果的关系。研究人员对104名抗精神病药物无效的FEP患者和80名健康对照组(HC)进行了血清免疫测定,以测量外周炎症细胞因子(IL-1β、IL-10、TNF-a)、KP限速酶(IDO/TDO)和犬尿酸(KYNA)代谢物的水平。在入院时和接受抗精神病药物治疗 4 周后,采用阳性和阴性综合征量表 (PANSS) 和全球功能评估量表 (GAF) 评估精神病理学和功能状况。与HC相比,FEP患者在抗精神病药物治疗前后的细胞因子和KP成分水平均大幅升高。在FEP患者中观察到促炎性IL-1β和KYNA水平之间存在明显的正相关,而在HC患者中则没有发现。重要的是,患者内部分析表明,基线 KYNA 水平较高的患者会出现更严重的阴性症状,随访时的临床改善程度也较差。这些研究结果表明,KP在早期精神病中上调,可能是通过诱导IL-1β依赖性途径,而外周KYNA升高可能是FEP患者对抗精神病药物无反应的一个有希望的指标。
{"title":"Elevated serum kynurenic acid in individuals with first-episode psychosis and insufficient response to antipsychotics.","authors":"Alex Hatzimanolis, Stefania Foteli, Lida-Alkisti Xenaki, Mirjana Selakovic, Stefanos Dimitrakopoulos, Ilias Vlachos, Ioannis Kosteletos, Rigas-Filippos Soldatos, Maria Gazouli, Stylianos Chatzipanagiotou, Nikos Stefanis","doi":"10.1038/s41537-024-00483-z","DOIUrl":"10.1038/s41537-024-00483-z","url":null,"abstract":"<p><p>The tryptophan-metabolizing kynurenine pathway (KP) can be activated by enhanced inflammatory responses and has been implicated in the pathophysiology of schizophrenia. However, there is little evidence for KP dysregulation in the early course of psychotic illness. We aimed to investigate the potential immune-mediated hyperactivity of KP in individuals with first-episode psychosis (FEP) and the relationship with symptom severity and treatment response outcomes. Serum immunoassays were performed to measure peripheral levels of inflammatory cytokines (IL-1β, IL-10, TNF-a), KP rate-limiting enzymes (IDO/TDO), and kynurenic acid (KYNA) metabolite in 104 antipsychotic-naïve patients with FEP and 80 healthy controls (HC). The Positive and Negative Syndrome Scale (PANSS) and the Global Assessment of Functioning Scale (GAF) were administered to assess psychopathology and functioning status at admission and following 4-week treatment with antipsychotics. Cytokine and KP components levels were substantially increased in FEP patients compared to HC, before and after antipsychotic treatment. A significant positive correlation between pro-inflammatory IL-1β and KYNA levels was observed among FEP patients, but not in HC. Importantly, within-patient analysis revealed that those with higher baseline KYNA experienced more severe negative symptoms and poorer clinical improvement at follow-up. These findings suggest that KP is upregulated in early psychosis, likely through the induction of IL-1β-dependent pathways, and raised peripheral KYNA might represent a promising indicator of non-response to antipsychotic medication in patients with FEP.</p>","PeriodicalId":74758,"journal":{"name":"Schizophrenia (Heidelberg, Germany)","volume":null,"pages":null},"PeriodicalIF":3.0,"publicationDate":"2024-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11237022/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141581788","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A systematic review of structural and functional magnetic resonance imaging studies on the neurobiology of depressive symptoms in schizophrenia spectrum disorders. 关于精神分裂症谱系障碍抑郁症状神经生物学的结构和功能磁共振成像研究的系统回顾。
IF 3 Q2 PSYCHIATRY Pub Date : 2024-07-04 DOI: 10.1038/s41537-024-00478-w
Julia Gallucci, Maria T Secara, Oliver Chen, Lindsay D Oliver, Brett D M Jones, Tulip Marawi, George Foussias, Aristotle N Voineskos, Colin Hawco

Depressive symptoms in Schizophrenia Spectrum Disorders (SSDs) negatively impact suicidality, prognosis, and quality of life. Despite this, efficacious treatments are limited, largely because the neural mechanisms underlying depressive symptoms in SSDs remain poorly understood. We conducted a systematic review to provide an overview of studies that investigated the neural correlates of depressive symptoms in SSDs using neuroimaging techniques. We searched MEDLINE, PsycINFO, EMBASE, Web of Science, and Cochrane Library databases from inception through June 19, 2023. Specifically, we focused on structural and functional magnetic resonance imaging (MRI), encompassing: (1) T1-weighted imaging measuring brain morphology; (2) diffusion-weighted imaging assessing white matter integrity; or (3) T2*-weighted imaging measures of brain function. Our search yielded 33 articles; 14 structural MRI studies, 18 functional (f)MRI studies, and 1 multimodal fMRI/MRI study. Reviewed studies indicate potential commonalities in the neurobiology of depressive symptoms between SSDs and major depressive disorders, particularly in subcortical and frontal brain regions, though confidence in this interpretation is limited. The review underscores a notable knowledge gap in our understanding of the neurobiology of depression in SSDs, marked by inconsistent approaches and few studies examining imaging metrics of depressive symptoms. Inconsistencies across studies' findings emphasize the necessity for more direct and comprehensive research focusing on the neurobiology of depression in SSDs. Future studies should go beyond "total score" depression metrics and adopt more nuanced assessment approaches considering distinct subdomains. This could reveal unique neurobiological profiles and inform investigations of targeted treatments for depression in SSDs.

精神分裂症谱系障碍(SSD)患者的抑郁症状会对自杀倾向、预后和生活质量产生负面影响。尽管如此,有效的治疗方法仍然有限,这主要是因为人们对精神分裂症谱系障碍抑郁症状的神经机制仍然知之甚少。我们进行了一项系统性综述,旨在概述使用神经影像技术调查 SSD 患者抑郁症状神经相关因素的研究。我们检索了从开始到 2023 年 6 月 19 日的 MEDLINE、PsycINFO、EMBASE、Web of Science 和 Cochrane Library 数据库。具体而言,我们重点关注结构性和功能性磁共振成像(MRI),包括:(1)测量大脑形态的 T1 加权成像;(2)评估白质完整性的弥散加权成像;或(3)测量大脑功能的 T2* 加权成像。我们的搜索共获得 33 篇文章;14 项结构性 MRI 研究、18 项功能性 (f)MRI 研究和 1 项多模态 fMRI/MRI 研究。综述研究表明,SSD 和重度抑郁障碍在抑郁症状的神经生物学方面存在潜在的共性,尤其是在皮层下和额叶脑区,但这种解释的可信度有限。综述强调了我们在了解 SSD 抑郁症神经生物学方面存在明显的知识空白,其特点是研究方法不一致,而且很少有研究对抑郁症状的成像指标进行检查。研究结果的不一致性强调了对 SSD 抑郁症神经生物学进行更直接、更全面研究的必要性。未来的研究应超越 "总分 "抑郁指标,采用更细致的评估方法,考虑不同的子域。这可以揭示独特的神经生物学特征,并为研究针对 SSD 抑郁症的治疗方法提供信息。
{"title":"A systematic review of structural and functional magnetic resonance imaging studies on the neurobiology of depressive symptoms in schizophrenia spectrum disorders.","authors":"Julia Gallucci, Maria T Secara, Oliver Chen, Lindsay D Oliver, Brett D M Jones, Tulip Marawi, George Foussias, Aristotle N Voineskos, Colin Hawco","doi":"10.1038/s41537-024-00478-w","DOIUrl":"10.1038/s41537-024-00478-w","url":null,"abstract":"<p><p>Depressive symptoms in Schizophrenia Spectrum Disorders (SSDs) negatively impact suicidality, prognosis, and quality of life. Despite this, efficacious treatments are limited, largely because the neural mechanisms underlying depressive symptoms in SSDs remain poorly understood. We conducted a systematic review to provide an overview of studies that investigated the neural correlates of depressive symptoms in SSDs using neuroimaging techniques. We searched MEDLINE, PsycINFO, EMBASE, Web of Science, and Cochrane Library databases from inception through June 19, 2023. Specifically, we focused on structural and functional magnetic resonance imaging (MRI), encompassing: (1) T1-weighted imaging measuring brain morphology; (2) diffusion-weighted imaging assessing white matter integrity; or (3) T2*-weighted imaging measures of brain function. Our search yielded 33 articles; 14 structural MRI studies, 18 functional (f)MRI studies, and 1 multimodal fMRI/MRI study. Reviewed studies indicate potential commonalities in the neurobiology of depressive symptoms between SSDs and major depressive disorders, particularly in subcortical and frontal brain regions, though confidence in this interpretation is limited. The review underscores a notable knowledge gap in our understanding of the neurobiology of depression in SSDs, marked by inconsistent approaches and few studies examining imaging metrics of depressive symptoms. Inconsistencies across studies' findings emphasize the necessity for more direct and comprehensive research focusing on the neurobiology of depression in SSDs. Future studies should go beyond \"total score\" depression metrics and adopt more nuanced assessment approaches considering distinct subdomains. This could reveal unique neurobiological profiles and inform investigations of targeted treatments for depression in SSDs.</p>","PeriodicalId":74758,"journal":{"name":"Schizophrenia (Heidelberg, Germany)","volume":null,"pages":null},"PeriodicalIF":3.0,"publicationDate":"2024-07-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11222445/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141499836","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Reduced speech coherence in psychosis-related social media forum posts. 与精神病有关的社交媒体论坛帖子中的语音连贯性降低。
IF 3 Q2 PSYCHIATRY Pub Date : 2024-07-04 DOI: 10.1038/s41537-024-00481-1
Laurin Plank, Armin Zlomuzica

The extraction of linguistic markers from social media posts, which are indicative of the onset and course of mental disorders, offers great potential for mental healthcare. In the present study, we extracted over one million posts from the popular social media platform Reddit to analyze speech coherence, which reflects formal thought disorder and is a characteristic feature of schizophrenia and associated psychotic disorders. Natural language processing (NLP) models were used to perform an automated quantification of speech coherence. We could demonstrate that users who are active on forums geared towards disorders with a higher degree of psychotic symptoms tend to show a lower level of coherence. The lowest coherence scores were found in users of forums on dissociative identity disorder, schizophrenia, and bipolar disorder. In contrast, a relatively high level of coherence was detected in users of forums related to obsessive-compulsive disorder, anxiety, and depression. Users of forums on posttraumatic stress disorder, autism, and attention-deficit hyperactivity disorder exhibited medium-level coherence. Our findings provide promising first evidence for the possible utility of NLP-based coherence analyses for the early detection and prevention of psychosis on the basis of posts gathered from publicly available social media data. This opens new avenues for large-scale prevention programs aimed at high-risk populations.

从社交媒体帖子中提取语言标记可反映精神障碍的发病和病程,这为精神保健提供了巨大的潜力。在本研究中,我们从流行的社交媒体平台 Reddit 上提取了 100 多万条帖子来分析语音连贯度,它反映了形式思维紊乱,是精神分裂症和相关精神障碍的特征之一。我们使用自然语言处理(NLP)模型对语音连贯性进行了自动量化。我们可以证明,活跃于精神症状程度较高的论坛的用户往往表现出较低的连贯性。在有关分离性身份识别障碍、精神分裂症和双相情感障碍的论坛中,用户的连贯性得分最低。相比之下,强迫症、焦虑症和抑郁症相关论坛用户的一致性水平相对较高。创伤后应激障碍、自闭症和注意力缺陷多动障碍论坛的用户则表现出中等程度的一致性。我们的研究结果首次证明,基于 NLP 的一致性分析可以在从公开社交媒体数据中收集的帖子的基础上,用于早期检测和预防精神病。这为针对高危人群的大规模预防计划开辟了新途径。
{"title":"Reduced speech coherence in psychosis-related social media forum posts.","authors":"Laurin Plank, Armin Zlomuzica","doi":"10.1038/s41537-024-00481-1","DOIUrl":"10.1038/s41537-024-00481-1","url":null,"abstract":"<p><p>The extraction of linguistic markers from social media posts, which are indicative of the onset and course of mental disorders, offers great potential for mental healthcare. In the present study, we extracted over one million posts from the popular social media platform Reddit to analyze speech coherence, which reflects formal thought disorder and is a characteristic feature of schizophrenia and associated psychotic disorders. Natural language processing (NLP) models were used to perform an automated quantification of speech coherence. We could demonstrate that users who are active on forums geared towards disorders with a higher degree of psychotic symptoms tend to show a lower level of coherence. The lowest coherence scores were found in users of forums on dissociative identity disorder, schizophrenia, and bipolar disorder. In contrast, a relatively high level of coherence was detected in users of forums related to obsessive-compulsive disorder, anxiety, and depression. Users of forums on posttraumatic stress disorder, autism, and attention-deficit hyperactivity disorder exhibited medium-level coherence. Our findings provide promising first evidence for the possible utility of NLP-based coherence analyses for the early detection and prevention of psychosis on the basis of posts gathered from publicly available social media data. This opens new avenues for large-scale prevention programs aimed at high-risk populations.</p>","PeriodicalId":74758,"journal":{"name":"Schizophrenia (Heidelberg, Germany)","volume":null,"pages":null},"PeriodicalIF":3.0,"publicationDate":"2024-07-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11224262/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141536162","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Functional phenotypes in schizophrenia spectrum disorders: defining the constructs and identifying biopsychosocial correlates using data-driven methods. 精神分裂症谱系障碍的功能表型:使用数据驱动方法定义结构并确定生物-心理-社会相关性。
IF 3 Q2 PSYCHIATRY Pub Date : 2024-06-24 DOI: 10.1038/s41537-024-00479-9
Sunny X Tang, Katrin Hänsel, Lindsay D Oliver, Erin W Dickie, Colin Hawco, Majnu John, Aristotle Voineskos, James M Gold, Robert W Buchanan, Anil K Malhotra

Functional impairments contribute to poor quality of life in schizophrenia spectrum disorders (SSD). We sought to (Objective I) define the main functional phenotypes in SSD, then (Objective II) identify key biopsychosocial correlates, emphasizing interpretable data-driven methods. Objective I was tested on independent samples: Dataset I (N = 282) and Dataset II (N = 317), with SSD participants who underwent assessment of multiple functioning areas. Participants were clustered based on functioning. Objective II was evaluated in Dataset I by identifying key features for classifying functional phenotype clusters from among 65 sociodemographic, psychological, clinical, cognitive, and brain volume measures. Findings were replicated across latent discriminant analyses (LDA) and one-vs.-rest binomial regularized regressions to identify key predictors. We identified three clusters of participants in each dataset, demonstrating replicable functional phenotypes: Cluster 1-poor functioning across domains; Cluster 2-impaired Role Functioning, but partially preserved Independent and Social Functioning; Cluster 3-good functioning across domains. Key correlates were Avolition, anhedonia, left hippocampal volume, and measures of emotional intelligence and subjective social experience. Avolition appeared more closely tied to role functioning, and anhedonia to independent and social functioning. Thus, we found three replicable functional phenotypes with evidence that recovery may not be uniform across domains. Avolition and anhedonia were both critical but played different roles for different functional domains. It may be important to identify critical functional areas for individual patients and target interventions accordingly.

功能障碍导致精神分裂症谱系障碍(SSD)患者生活质量低下。我们试图(目标一)定义精神分裂症谱系障碍的主要功能表型,然后(目标二)确定关键的生物-心理-社会相关因素,强调可解释的数据驱动方法。目标 I 在独立样本上进行了测试:数据集 I(N = 282)和数据集 II(N = 317)中的 SSD 参与者接受了多个功能领域的评估。根据功能对参与者进行分组。目标 II 在数据集 I 中进行了评估,从 65 个社会人口、心理、临床、认知和脑容量测量指标中识别出功能表型集群分类的关键特征。研究结果在潜在判别分析(LDA)和一vs.-rest二项式正则回归中得到了重复,以确定关键的预测因素。我们在每个数据集中发现了三个参与者集群,展示了可复制的功能表型:第 1 组--各领域功能较差;第 2 组--角色功能受损,但独立和社交功能部分保留;第 3 组--各领域功能良好。与之相关的主要因素包括逃避、失乐症、左侧海马体积以及情商和主观社会体验的测量。逃避似乎与角色功能更密切相关,而失乐症则与独立和社会功能更密切相关。因此,我们发现了三种可复制的功能表型,有证据表明不同领域的恢复可能并不一致。逃避和失乐症都很关键,但在不同的功能领域发挥着不同的作用。确定个体患者的关键功能领域并有针对性地进行干预可能非常重要。
{"title":"Functional phenotypes in schizophrenia spectrum disorders: defining the constructs and identifying biopsychosocial correlates using data-driven methods.","authors":"Sunny X Tang, Katrin Hänsel, Lindsay D Oliver, Erin W Dickie, Colin Hawco, Majnu John, Aristotle Voineskos, James M Gold, Robert W Buchanan, Anil K Malhotra","doi":"10.1038/s41537-024-00479-9","DOIUrl":"10.1038/s41537-024-00479-9","url":null,"abstract":"<p><p>Functional impairments contribute to poor quality of life in schizophrenia spectrum disorders (SSD). We sought to (Objective I) define the main functional phenotypes in SSD, then (Objective II) identify key biopsychosocial correlates, emphasizing interpretable data-driven methods. Objective I was tested on independent samples: Dataset I (N = 282) and Dataset II (N = 317), with SSD participants who underwent assessment of multiple functioning areas. Participants were clustered based on functioning. Objective II was evaluated in Dataset I by identifying key features for classifying functional phenotype clusters from among 65 sociodemographic, psychological, clinical, cognitive, and brain volume measures. Findings were replicated across latent discriminant analyses (LDA) and one-vs.-rest binomial regularized regressions to identify key predictors. We identified three clusters of participants in each dataset, demonstrating replicable functional phenotypes: Cluster 1-poor functioning across domains; Cluster 2-impaired Role Functioning, but partially preserved Independent and Social Functioning; Cluster 3-good functioning across domains. Key correlates were Avolition, anhedonia, left hippocampal volume, and measures of emotional intelligence and subjective social experience. Avolition appeared more closely tied to role functioning, and anhedonia to independent and social functioning. Thus, we found three replicable functional phenotypes with evidence that recovery may not be uniform across domains. Avolition and anhedonia were both critical but played different roles for different functional domains. It may be important to identify critical functional areas for individual patients and target interventions accordingly.</p>","PeriodicalId":74758,"journal":{"name":"Schizophrenia (Heidelberg, Germany)","volume":null,"pages":null},"PeriodicalIF":3.0,"publicationDate":"2024-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11196713/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141447737","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Topological abnormalities of the morphometric similarity network of the cerebral cortex in schizophrenia. 精神分裂症患者大脑皮层形态计量相似性网络的拓扑异常。
Q2 PSYCHIATRY Pub Date : 2024-06-17 DOI: 10.1038/s41537-024-00477-x
Sung Woo Joo, Young Tak Jo, Woohyeok Choi, Sun Min Kim, So Young Yoo, Soohyun Joe, Jungsun Lee

A morphometric similarity (MS) network can be constructed using multiple magnetic resonance imaging parameters of each cortical region. An MS network can be used to assess the similarity between cortical regions. Although MS networks can detect microstructural alterations and capture connections between histologically similar cortical areas, the influence of schizophrenia on the topological characteristics of MS networks remains unclear. We obtained T1- and diffusion-weighted images of 239 healthy controls and 190 individuals with schizophrenia to construct the MS network. Group comparisons of the mean MS of the cortical regions and subnetworks were performed. The strengths of the connections between the cortical regions and the global and nodal network indices were compared between the groups. Clinical associations with the network indices were tested using Spearman's rho. Compared with healthy controls, individuals with schizophrenia had significant group differences in the mean MS of several cortical regions and subnetworks. Individuals with schizophrenia had both superior and inferior strengths of connections between cortical regions compared with those of healthy controls. We observed regional abnormalities of the MS network in individuals with schizophrenia regarding lower centrality values of the pars opercularis, superior frontal, and superior temporal areas. Specific nodal network measures of the right pars opercularis and left superior temporal areas were associated with illness duration in individuals with schizophrenia. We identified regional abnormalities of the MS network in schizophrenia with the left superior temporal area possibly being a key region in topological organization and cortical connections.

利用每个皮层区域的多个磁共振成像参数,可以构建一个形态计量相似性(MS)网络。MS 网络可用于评估皮质区域之间的相似性。虽然MS网络可以检测微观结构的改变并捕捉组织学上相似的皮质区域之间的联系,但精神分裂症对MS网络拓扑特征的影响仍不清楚。我们获取了 239 名健康对照组和 190 名精神分裂症患者的 T1 和弥散加权图像来构建 MS 网络。我们对皮质区域和子网的平均 MS 进行了分组比较。比较了各组之间皮质区域之间的连接强度以及整体和节点网络指数。使用Spearman's rho检验了网络指数与临床的关联性。与健康对照组相比,精神分裂症患者在几个皮层区域和子网的平均MS方面存在显著的群体差异。与健康对照组相比,精神分裂症患者大脑皮层区域之间的连接强度有高有低。我们观察到精神分裂症患者的 MS 网络存在区域性异常,其中眼旁、额叶上部和颞叶上部区域的中心性值较低。在精神分裂症患者中,右侧眼旁和左侧颞上区的特定节点网络测量值与病程有关。我们发现精神分裂症患者的多发性硬化症网络存在区域性异常,而左侧颞上区可能是拓扑组织和皮层连接的关键区域。
{"title":"Topological abnormalities of the morphometric similarity network of the cerebral cortex in schizophrenia.","authors":"Sung Woo Joo, Young Tak Jo, Woohyeok Choi, Sun Min Kim, So Young Yoo, Soohyun Joe, Jungsun Lee","doi":"10.1038/s41537-024-00477-x","DOIUrl":"10.1038/s41537-024-00477-x","url":null,"abstract":"<p><p>A morphometric similarity (MS) network can be constructed using multiple magnetic resonance imaging parameters of each cortical region. An MS network can be used to assess the similarity between cortical regions. Although MS networks can detect microstructural alterations and capture connections between histologically similar cortical areas, the influence of schizophrenia on the topological characteristics of MS networks remains unclear. We obtained T1- and diffusion-weighted images of 239 healthy controls and 190 individuals with schizophrenia to construct the MS network. Group comparisons of the mean MS of the cortical regions and subnetworks were performed. The strengths of the connections between the cortical regions and the global and nodal network indices were compared between the groups. Clinical associations with the network indices were tested using Spearman's rho. Compared with healthy controls, individuals with schizophrenia had significant group differences in the mean MS of several cortical regions and subnetworks. Individuals with schizophrenia had both superior and inferior strengths of connections between cortical regions compared with those of healthy controls. We observed regional abnormalities of the MS network in individuals with schizophrenia regarding lower centrality values of the pars opercularis, superior frontal, and superior temporal areas. Specific nodal network measures of the right pars opercularis and left superior temporal areas were associated with illness duration in individuals with schizophrenia. We identified regional abnormalities of the MS network in schizophrenia with the left superior temporal area possibly being a key region in topological organization and cortical connections.</p>","PeriodicalId":74758,"journal":{"name":"Schizophrenia (Heidelberg, Germany)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11183129/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141422177","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Excitation/inhibition imbalance in schizophrenia: a meta-analysis of inhibitory and excitatory TMS-EMG paradigms. 精神分裂症的兴奋/抑制失衡:抑制性和兴奋性 TMS-EMG 范例的荟萃分析。
Q2 PSYCHIATRY Pub Date : 2024-06-15 DOI: 10.1038/s41537-024-00476-y
Orsolya Lányi, Boróka Koleszár, Alexander Schulze Wenning, David Balogh, Marie Anne Engh, András Attila Horváth, Péter Fehérvari, Péter Hegyi, Zsolt Molnár, Zsolt Unoka, Gábor Csukly

Cortical excitation-inhibition (E/I) imbalance is a potential model for the pathophysiology of schizophrenia. Previous research using transcranial magnetic stimulation (TMS) and electromyography (EMG) has suggested inhibitory deficits in schizophrenia. In this meta-analysis we assessed the reliability and clinical potential of TMS-EMG paradigms in schizophrenia following the methodological recommendations of the PRISMA guideline and the Cochrane Handbook. The search was conducted in three databases in November 2022. Included articles reported Short-Interval Intracortical Inhibition (SICI), Intracortical Facilitation (ICF), Long-Interval Intracortical Inhibition (LICI) and Cortical Silent Period (CSP) in patients with schizophrenia and healthy controls. Meta-analyses were conducted using a random-effects model. Subgroup analysis and meta-regressions were used to assess heterogeneity. Results of 36 studies revealed a robust inhibitory deficit in schizophrenia with a significant decrease in SICI (Cohen's d: 0.62). A trend-level association was found between SICI and antipsychotic medication. Our findings support the E/I imbalance hypothesis in schizophrenia and suggest that SICI may be a potential pathophysiological characteristic of the disorder.

皮层兴奋-抑制(E/I)失衡是精神分裂症病理生理学的一个潜在模型。此前使用经颅磁刺激(TMS)和肌电图(EMG)进行的研究表明,精神分裂症患者存在抑制功能障碍。在这项荟萃分析中,我们按照 PRISMA 指南和 Cochrane 手册的方法学建议,评估了 TMS-EMG 范式在精神分裂症中的可靠性和临床潜力。该研究于 2022 年 11 月在三个数据库中进行了检索。纳入的文章报告了精神分裂症患者和健康对照组的短时皮质内抑制(SICI)、皮质内促进(ICF)、长时皮质内抑制(LICI)和皮质静默期(CSP)。元分析采用随机效应模型进行。分组分析和元回归用于评估异质性。36 项研究的结果表明,精神分裂症患者存在严重的抑制缺陷,SICI 显著下降(Cohen's d:0.62)。SICI与抗精神病药物之间存在趋势性关联。我们的研究结果支持精神分裂症的E/I失衡假说,并表明SICI可能是精神分裂症的一个潜在病理生理特征。
{"title":"Excitation/inhibition imbalance in schizophrenia: a meta-analysis of inhibitory and excitatory TMS-EMG paradigms.","authors":"Orsolya Lányi, Boróka Koleszár, Alexander Schulze Wenning, David Balogh, Marie Anne Engh, András Attila Horváth, Péter Fehérvari, Péter Hegyi, Zsolt Molnár, Zsolt Unoka, Gábor Csukly","doi":"10.1038/s41537-024-00476-y","DOIUrl":"10.1038/s41537-024-00476-y","url":null,"abstract":"<p><p>Cortical excitation-inhibition (E/I) imbalance is a potential model for the pathophysiology of schizophrenia. Previous research using transcranial magnetic stimulation (TMS) and electromyography (EMG) has suggested inhibitory deficits in schizophrenia. In this meta-analysis we assessed the reliability and clinical potential of TMS-EMG paradigms in schizophrenia following the methodological recommendations of the PRISMA guideline and the Cochrane Handbook. The search was conducted in three databases in November 2022. Included articles reported Short-Interval Intracortical Inhibition (SICI), Intracortical Facilitation (ICF), Long-Interval Intracortical Inhibition (LICI) and Cortical Silent Period (CSP) in patients with schizophrenia and healthy controls. Meta-analyses were conducted using a random-effects model. Subgroup analysis and meta-regressions were used to assess heterogeneity. Results of 36 studies revealed a robust inhibitory deficit in schizophrenia with a significant decrease in SICI (Cohen's d: 0.62). A trend-level association was found between SICI and antipsychotic medication. Our findings support the E/I imbalance hypothesis in schizophrenia and suggest that SICI may be a potential pathophysiological characteristic of the disorder.</p>","PeriodicalId":74758,"journal":{"name":"Schizophrenia (Heidelberg, Germany)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11180212/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141328204","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Copy number deletion of PLA2G4A affects the susceptibility and clinical phenotypes of schizophrenia. PLA2G4A 的拷贝数缺失会影响精神分裂症的易感性和临床表型。
Pub Date : 2024-05-30 DOI: 10.1038/s41537-024-00474-0
Zibo Gao, Xinru Guo, Zhouyang Sun, Songyu Wu, Qianyi Wang, Qianlong Huang, Wei Bai, Changgui Kou

Phospholipase A2(PLA2) superfamily is recognized as being involved in the pathogenesis of schizophrenia by affecting lipid homeostasis in cell membranes. We hypothesized that PLA2 gene copy number variation (CNV) may affect PLA2 enzyme expression and be associated with schizophrenia risk. This study indicated that in the discovery stage, an increased copy number of PLA2G6 and the deletion of PLA2G3, PLA2G4A, PLA2G4F and PLA2G12F was associated with increased risk of schizophrenia. CNV segments involving six PLA2 genes were detected in publicly available datasets, including two deletion segments specific to the PLA2G4A gene. The relationship between the deletion of PLA2G4A and susceptibility to schizophrenia was then reaffirmed in the validation group of 806 individuals. There was a significant correlation between PLA2G4A deletion and the symptoms of poverty of thought in male patients and erotomanic delusion in females. Furthermore, ELISA results demonstrate a significant decrease in peripheral blood cytosolic PLA2(cPLA2) levels in patients with the PLA2G4A deletion genotype compared to those with normal and copy number duplicate genotypes. These data suggest that the functional copy number deletion in the PLA2G4A gene is associated with the risk of schizophrenia and clinical phenotypes by reducing the expression of cPLA2, which may be an indicator of susceptibility to schizophrenia.

磷脂酶 A2(PLA2)超家族被认为通过影响细胞膜的脂质平衡参与了精神分裂症的发病机制。我们假设 PLA2 基因拷贝数变异(CNV)可能会影响 PLA2 酶的表达,并与精神分裂症风险相关。这项研究表明,在发现阶段,PLA2G6拷贝数的增加以及PLA2G3、PLA2G4A、PLA2G4F和PLA2G12F的缺失与精神分裂症风险的增加有关。在公开数据集中检测到了涉及六个 PLA2 基因的 CNV 片段,其中包括两个 PLA2G4A 基因特有的缺失片段。随后,在由 806 人组成的验证组中再次证实了 PLA2G4A 基因缺失与精神分裂症易感性之间的关系。PLA2G4A 基因缺失与男性患者的思维贫乏症状和女性患者的色情妄想症状之间存在明显的相关性。此外,酶联免疫吸附试验结果表明,与正常基因型和拷贝数重复基因型的患者相比,PLA2G4A缺失基因型患者的外周血细胞膜PLA2(cPLA2)水平明显下降。这些数据表明,PLA2G4A 基因功能拷贝数缺失通过降低 cPLA2 的表达与精神分裂症的患病风险和临床表型有关,而 cPLA2 的表达可能是精神分裂症易感性的一个指标。
{"title":"Copy number deletion of PLA2G4A affects the susceptibility and clinical phenotypes of schizophrenia.","authors":"Zibo Gao, Xinru Guo, Zhouyang Sun, Songyu Wu, Qianyi Wang, Qianlong Huang, Wei Bai, Changgui Kou","doi":"10.1038/s41537-024-00474-0","DOIUrl":"10.1038/s41537-024-00474-0","url":null,"abstract":"<p><p>Phospholipase A2(PLA2) superfamily is recognized as being involved in the pathogenesis of schizophrenia by affecting lipid homeostasis in cell membranes. We hypothesized that PLA2 gene copy number variation (CNV) may affect PLA2 enzyme expression and be associated with schizophrenia risk. This study indicated that in the discovery stage, an increased copy number of PLA2G6 and the deletion of PLA2G3, PLA2G4A, PLA2G4F and PLA2G12F was associated with increased risk of schizophrenia. CNV segments involving six PLA2 genes were detected in publicly available datasets, including two deletion segments specific to the PLA2G4A gene. The relationship between the deletion of PLA2G4A and susceptibility to schizophrenia was then reaffirmed in the validation group of 806 individuals. There was a significant correlation between PLA2G4A deletion and the symptoms of poverty of thought in male patients and erotomanic delusion in females. Furthermore, ELISA results demonstrate a significant decrease in peripheral blood cytosolic PLA2(cPLA2) levels in patients with the PLA2G4A deletion genotype compared to those with normal and copy number duplicate genotypes. These data suggest that the functional copy number deletion in the PLA2G4A gene is associated with the risk of schizophrenia and clinical phenotypes by reducing the expression of cPLA2, which may be an indicator of susceptibility to schizophrenia.</p>","PeriodicalId":74758,"journal":{"name":"Schizophrenia (Heidelberg, Germany)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11139948/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141181323","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Multimodal fusion of brain signals for robust prediction of psychosis transition. 多模态融合大脑信号,稳健预测精神病转变。
Pub Date : 2024-05-21 DOI: 10.1038/s41537-024-00464-2
Jenna M Reinen, Pablo Polosecki, Eduardo Castro, Cheryl M Corcoran, Guillermo A Cecchi, Tiziano Colibazzi

The prospective study of youths at clinical high risk (CHR) for psychosis, including neuroimaging, can identify neural signatures predictive of psychosis outcomes using algorithms that integrate complex information. Here, to identify risk and psychosis conversion, we implemented multiple kernel learning (MKL), a multimodal machine learning approach allowing patterns from each modality to inform each other. Baseline multimodal scans (n = 74, 11 converters) included structural, resting-state functional imaging, and diffusion-weighted data. Multimodal MKL outperformed unimodal models (AUC = 0.73 vs. 0.66 in predicting conversion). Moreover, patterns learned by MKL were robust to training set variations, suggesting it can identify cross-modality redundancies and synergies to stabilize the predictive pattern. We identified many predictors consistent with the literature, including frontal cortices, cingulate, thalamus, and striatum. This highlights the advantage of methods that leverage the complex pathophysiology of psychosis.

对处于精神病临床高风险(CHR)的青少年进行前瞻性研究,包括神经影像学研究,可以利用整合复杂信息的算法识别预测精神病结果的神经特征。在这里,为了识别风险和精神病转换,我们采用了多核学习(MKL),这是一种多模态机器学习方法,可以让每种模态的模式相互借鉴。基线多模态扫描(n = 74,11 名转换者)包括结构、静息态功能成像和弥散加权数据。多模态 MKL 的表现优于单模态模型(预测转换的 AUC = 0.73 对 0.66)。此外,MKL 学习到的模式对训练集的变化具有鲁棒性,这表明它可以识别跨模态冗余和协同作用,从而稳定预测模式。我们发现了许多与文献一致的预测因子,包括额叶皮层、扣带回、丘脑和纹状体。这凸显了利用精神病复杂病理生理学的方法的优势。
{"title":"Multimodal fusion of brain signals for robust prediction of psychosis transition.","authors":"Jenna M Reinen, Pablo Polosecki, Eduardo Castro, Cheryl M Corcoran, Guillermo A Cecchi, Tiziano Colibazzi","doi":"10.1038/s41537-024-00464-2","DOIUrl":"10.1038/s41537-024-00464-2","url":null,"abstract":"<p><p>The prospective study of youths at clinical high risk (CHR) for psychosis, including neuroimaging, can identify neural signatures predictive of psychosis outcomes using algorithms that integrate complex information. Here, to identify risk and psychosis conversion, we implemented multiple kernel learning (MKL), a multimodal machine learning approach allowing patterns from each modality to inform each other. Baseline multimodal scans (n = 74, 11 converters) included structural, resting-state functional imaging, and diffusion-weighted data. Multimodal MKL outperformed unimodal models (AUC = 0.73 vs. 0.66 in predicting conversion). Moreover, patterns learned by MKL were robust to training set variations, suggesting it can identify cross-modality redundancies and synergies to stabilize the predictive pattern. We identified many predictors consistent with the literature, including frontal cortices, cingulate, thalamus, and striatum. This highlights the advantage of methods that leverage the complex pathophysiology of psychosis.</p>","PeriodicalId":74758,"journal":{"name":"Schizophrenia (Heidelberg, Germany)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-05-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11109212/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141077461","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The contribution of prosody to machine classification of schizophrenia. 前奏对精神分裂症机器分类的贡献。
Pub Date : 2024-05-18 DOI: 10.1038/s41537-024-00463-3
Tomer Ben Moshe, Ido Ziv, Nachum Dershowitz, Kfir Bar

We show how acoustic prosodic features, such as pitch and gaps, can be used computationally for detecting symptoms of schizophrenia from a single spoken response. We compare the individual contributions of acoustic and previously-employed text modalities to the algorithmic determination whether the speaker has schizophrenia. Our classification results clearly show that we can extract relevant acoustic features better than those textual ones. We find that, when combined with those acoustic features, textual features improve classification only slightly.

我们展示了如何通过计算利用声学前音特征(如音高和间隙)从单个口语应答中检测出精神分裂症的症状。我们比较了声学模态和以前使用的文本模态对算法判断说话者是否患有精神分裂症的各自贡献。我们的分类结果清楚地表明,我们能比文字模式更好地提取相关的声学特征。我们发现,当与这些声学特征相结合时,文本特征只能稍微改善分类效果。
{"title":"The contribution of prosody to machine classification of schizophrenia.","authors":"Tomer Ben Moshe, Ido Ziv, Nachum Dershowitz, Kfir Bar","doi":"10.1038/s41537-024-00463-3","DOIUrl":"10.1038/s41537-024-00463-3","url":null,"abstract":"<p><p>We show how acoustic prosodic features, such as pitch and gaps, can be used computationally for detecting symptoms of schizophrenia from a single spoken response. We compare the individual contributions of acoustic and previously-employed text modalities to the algorithmic determination whether the speaker has schizophrenia. Our classification results clearly show that we can extract relevant acoustic features better than those textual ones. We find that, when combined with those acoustic features, textual features improve classification only slightly.</p>","PeriodicalId":74758,"journal":{"name":"Schizophrenia (Heidelberg, Germany)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-05-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11102498/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140961174","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Combination of UGT1A1 polymorphism and baseline plasma bilirubin levels in predicting the risk of antipsychotic-induced dyslipidemia in schizophrenia patients. 结合 UGT1A1 多态性和血浆胆红素基线水平预测精神分裂症患者因抗精神病药引起血脂异常的风险。
Pub Date : 2024-05-17 DOI: 10.1038/s41537-024-00473-1
Chenquan Lin, Shuangyang Zhang, Ping Yang, Bikui Zhang, Wenbin Guo, Renrong Wu, Yong Liu, Jianjian Wang, Haishan Wu, Hualin Cai

The prolonged usage of atypical antipsychotic drugs (AAPD) among individuals with schizophrenia often leads to metabolic side effects such as dyslipidemia. These effects not only limit one's selection of AAPD but also significantly reduce compliance and quality of life of patients. Recent studies suggest that bilirubin plays a crucial role in maintaining lipid homeostasis and may be a potential pre-treatment biomarker for individuals with dyslipidemia. The present study included 644 schizophrenia patients from two centers. Demographic and clinical characteristics were collected at baseline and 4 weeks after admission to investigate the correlation between metabolites, episodes, usage of AAPDs, and occurrence of dyslipidemia. Besides, we explored the combined predictive value of genotypes and baseline bilirubin for dyslipidemia by employing multiple PCR targeted capture techniques to sequence two pathways: bilirubin metabolism-related genes and lipid metabolism-related genes. Our results indicated that there existed a negative correlation between the changes in bilirubin levels and triglyceride (TG) levels in patients with schizophrenia. Among three types of bilirubin, direct bilirubin in the baseline (DBIL-bl) proved to be the most effective in predicting dyslipidemia in the ROC analysis (AUC = 0.627, p < 0.001). Furthermore, the odds ratio from multinomial logistic regression analysis showed that UGT1A1*6 was a protective factor for dyslipidemia (ß = -12.868, p < 0.001). The combination of baseline DBIL and UGT1A1*6 significantly improved the performance in predicting dyslipidemia (AUC = 0.939, p < 0.001). Schizophrenia patients with UGT1A1*6 mutation and a certain level of baseline bilirubin may be more resistant to dyslipidemia and have more selections for AAPD than other patients.

精神分裂症患者长期服用非典型抗精神病药物(AAPD)往往会导致血脂异常等代谢副作用。这些副作用不仅限制了患者对非典型抗精神病药物的选择,还大大降低了患者的依从性和生活质量。最近的研究表明,胆红素在维持血脂平衡方面起着至关重要的作用,可能成为血脂异常患者治疗前的潜在生物标志物。本研究纳入了来自两个中心的 644 名精神分裂症患者。我们收集了基线和入院 4 周后的人口统计学和临床特征,以研究代谢物、发作、AAPDs 的使用和血脂异常发生之间的相关性。此外,我们还采用多种 PCR 靶向捕获技术,对胆红素代谢相关基因和脂质代谢相关基因两条通路进行测序,探讨了基因型和基线胆红素对血脂异常的综合预测价值。结果表明,精神分裂症患者胆红素水平的变化与甘油三酯(TG)水平之间存在负相关。在三种胆红素中,基线直接胆红素(DBIL-bl)在 ROC 分析中被证明是预测血脂异常最有效的指标(AUC = 0.627,p<0.05)。
{"title":"Combination of UGT1A1 polymorphism and baseline plasma bilirubin levels in predicting the risk of antipsychotic-induced dyslipidemia in schizophrenia patients.","authors":"Chenquan Lin, Shuangyang Zhang, Ping Yang, Bikui Zhang, Wenbin Guo, Renrong Wu, Yong Liu, Jianjian Wang, Haishan Wu, Hualin Cai","doi":"10.1038/s41537-024-00473-1","DOIUrl":"10.1038/s41537-024-00473-1","url":null,"abstract":"<p><p>The prolonged usage of atypical antipsychotic drugs (AAPD) among individuals with schizophrenia often leads to metabolic side effects such as dyslipidemia. These effects not only limit one's selection of AAPD but also significantly reduce compliance and quality of life of patients. Recent studies suggest that bilirubin plays a crucial role in maintaining lipid homeostasis and may be a potential pre-treatment biomarker for individuals with dyslipidemia. The present study included 644 schizophrenia patients from two centers. Demographic and clinical characteristics were collected at baseline and 4 weeks after admission to investigate the correlation between metabolites, episodes, usage of AAPDs, and occurrence of dyslipidemia. Besides, we explored the combined predictive value of genotypes and baseline bilirubin for dyslipidemia by employing multiple PCR targeted capture techniques to sequence two pathways: bilirubin metabolism-related genes and lipid metabolism-related genes. Our results indicated that there existed a negative correlation between the changes in bilirubin levels and triglyceride (TG) levels in patients with schizophrenia. Among three types of bilirubin, direct bilirubin in the baseline (DBIL-bl) proved to be the most effective in predicting dyslipidemia in the ROC analysis (AUC = 0.627, p < 0.001). Furthermore, the odds ratio from multinomial logistic regression analysis showed that UGT1A1*6 was a protective factor for dyslipidemia (ß = -12.868, p < 0.001). The combination of baseline DBIL and UGT1A1*6 significantly improved the performance in predicting dyslipidemia (AUC = 0.939, p < 0.001). Schizophrenia patients with UGT1A1*6 mutation and a certain level of baseline bilirubin may be more resistant to dyslipidemia and have more selections for AAPD than other patients.</p>","PeriodicalId":74758,"journal":{"name":"Schizophrenia (Heidelberg, Germany)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-05-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11101411/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140961109","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
期刊
Schizophrenia (Heidelberg, Germany)
全部 Acc. Chem. Res. ACS Applied Bio Materials ACS Appl. Electron. Mater. ACS Appl. Energy Mater. ACS Appl. Mater. Interfaces ACS Appl. Nano Mater. ACS Appl. Polym. Mater. ACS BIOMATER-SCI ENG ACS Catal. ACS Cent. Sci. ACS Chem. Biol. ACS Chemical Health & Safety ACS Chem. Neurosci. ACS Comb. Sci. ACS Earth Space Chem. ACS Energy Lett. ACS Infect. Dis. ACS Macro Lett. ACS Mater. Lett. ACS Med. Chem. Lett. ACS Nano ACS Omega ACS Photonics ACS Sens. ACS Sustainable Chem. Eng. ACS Synth. Biol. Anal. Chem. BIOCHEMISTRY-US Bioconjugate Chem. BIOMACROMOLECULES Chem. Res. Toxicol. Chem. Rev. Chem. Mater. CRYST GROWTH DES ENERG FUEL Environ. Sci. Technol. Environ. Sci. Technol. Lett. Eur. J. Inorg. Chem. IND ENG CHEM RES Inorg. Chem. J. Agric. Food. Chem. J. Chem. Eng. Data J. Chem. Educ. J. Chem. Inf. Model. J. Chem. Theory Comput. J. Med. Chem. J. Nat. Prod. J PROTEOME RES J. Am. Chem. Soc. LANGMUIR MACROMOLECULES Mol. Pharmaceutics Nano Lett. Org. Lett. ORG PROCESS RES DEV ORGANOMETALLICS J. Org. Chem. J. Phys. Chem. J. Phys. Chem. A J. Phys. Chem. B J. Phys. Chem. C J. Phys. Chem. Lett. Analyst Anal. Methods Biomater. Sci. Catal. Sci. Technol. Chem. Commun. Chem. Soc. Rev. CHEM EDUC RES PRACT CRYSTENGCOMM Dalton Trans. Energy Environ. Sci. ENVIRON SCI-NANO ENVIRON SCI-PROC IMP ENVIRON SCI-WAT RES Faraday Discuss. Food Funct. Green Chem. Inorg. Chem. Front. Integr. Biol. J. Anal. At. Spectrom. J. Mater. Chem. A J. Mater. Chem. B J. Mater. Chem. C Lab Chip Mater. Chem. Front. Mater. Horiz. MEDCHEMCOMM Metallomics Mol. Biosyst. Mol. Syst. Des. Eng. Nanoscale Nanoscale Horiz. Nat. Prod. Rep. New J. Chem. Org. Biomol. Chem. Org. Chem. Front. PHOTOCH PHOTOBIO SCI PCCP Polym. Chem.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1