With the rapid development of autonomous driving technology, issues regarding safe decision-making and multi-vehicle collaboration in complex urban environments have become increasingly prominent. To address the limitations of existing deep reinforcement learning methods in computational efficiency, decision transparency, and system safety, this paper proposes a novel framework, SVD-BDRL, which integrates a sparse voxel decoder and blockchain-enhanced deep reinforcement learning. The framework brings three key innovations: a sparse voxelization method to reduce computational complexity at the perception layer; a blockchain-based distributed experience management system to ensure data authenticity at the decision layer; and a real-time anomaly detection system combining graph neural networks and consortium blockchain for verification. Experimental results demonstrate that on the NuScenes and CARLA datasets, SVD-BDRL outperforms current methods, achieving an 11% reduction in collision rate and a 3.4% decrease in trajectory error, while maintaining real-time performance at 23.5 FPS. This study presents a promising new approach for creating safe, trustworthy autonomous driving systems, which is crucial for the commercialization of autonomous vehicles.
{"title":"SVD-BDRL: A trustworthy autonomous driving decision framework based on sparse voxels and blockchain enhancement","authors":"Zhongsheng Tang , Yetao Feng , Jian Zhang , Zihao Wang","doi":"10.1016/j.aej.2025.11.040","DOIUrl":"10.1016/j.aej.2025.11.040","url":null,"abstract":"<div><div>With the rapid development of autonomous driving technology, issues regarding safe decision-making and multi-vehicle collaboration in complex urban environments have become increasingly prominent. To address the limitations of existing deep reinforcement learning methods in computational efficiency, decision transparency, and system safety, this paper proposes a novel framework, SVD-BDRL, which integrates a sparse voxel decoder and blockchain-enhanced deep reinforcement learning. The framework brings three key innovations: a sparse voxelization method to reduce computational complexity at the perception layer; a blockchain-based distributed experience management system to ensure data authenticity at the decision layer; and a real-time anomaly detection system combining graph neural networks and consortium blockchain for verification. Experimental results demonstrate that on the NuScenes and CARLA datasets, SVD-BDRL outperforms current methods, achieving an 11% reduction in collision rate and a 3.4% decrease in trajectory error, while maintaining real-time performance at 23.5 FPS. This study presents a promising new approach for creating safe, trustworthy autonomous driving systems, which is crucial for the commercialization of autonomous vehicles.</div></div>","PeriodicalId":7484,"journal":{"name":"alexandria engineering journal","volume":"134 ","pages":"Pages 433-446"},"PeriodicalIF":6.8,"publicationDate":"2025-12-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145788024","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-12-19DOI: 10.1016/j.aej.2025.11.036
Mohan Wang , Zhong Wen
Multimodal sentiment recognition enables precise analysis and classification of human emotions. However, existing methods face three major challenges: low feature fusion efficiency due to modality heterogeneity, insufficient long-range dependency modeling capability, and high model complexity. To address these issues, this paper proposes the EmoMamFusion model for multimodal sentiment recognition, based on a differentiated dual-branch fusion architecture. Specifically, the model achieves differentiated fusion through the TranFusion and MamFusion branches: TranFusion, centered around cross-attention, performs preliminary cross-modal semantic alignment and shallow feature fusion; MamFusion models long-range dependencies through the Mamba network and enforces cross-modal collaboration with InfoNCE loss, enabling deep feature fusion and semantic enhancement. Finally, the features from both branches are globally integrated by a Transformer encoder to complete sentiment category prediction. Experiments on the CMU-MOSI and CMU-MOSEI datasets show that EmoMamFusion outperforms 22 state-of-the-art methods in core metrics such as binary classification accuracy (Acc-2), F1 score, seven-class accuracy (Acc-7), and Pearson correlation coefficient (Corr). Specifically, on the CMU-MOSI dataset, Acc-7 and Corr reached 50.96% and 0.895, respectively, while on the CMU-MOSEI dataset, Acc-7 and Corr reached 54.98% and 0.821. At the same time, the model has only 1.38M parameters, achieving a collaborative optimization of high performance and lightweight design.
{"title":"EmoMamFusion: A sentiment classification algorithm framework based on a differentiated dual-branch fusion architecture","authors":"Mohan Wang , Zhong Wen","doi":"10.1016/j.aej.2025.11.036","DOIUrl":"10.1016/j.aej.2025.11.036","url":null,"abstract":"<div><div>Multimodal sentiment recognition enables precise analysis and classification of human emotions. However, existing methods face three major challenges: low feature fusion efficiency due to modality heterogeneity, insufficient long-range dependency modeling capability, and high model complexity. To address these issues, this paper proposes the EmoMamFusion model for multimodal sentiment recognition, based on a differentiated dual-branch fusion architecture. Specifically, the model achieves differentiated fusion through the TranFusion and MamFusion branches: TranFusion, centered around cross-attention, performs preliminary cross-modal semantic alignment and shallow feature fusion; MamFusion models long-range dependencies through the Mamba network and enforces cross-modal collaboration with InfoNCE loss, enabling deep feature fusion and semantic enhancement. Finally, the features from both branches are globally integrated by a Transformer encoder to complete sentiment category prediction. Experiments on the CMU-MOSI and CMU-MOSEI datasets show that EmoMamFusion outperforms 22 state-of-the-art methods in core metrics such as binary classification accuracy (Acc-2), F1 score, seven-class accuracy (Acc-7), and Pearson correlation coefficient (Corr). Specifically, on the CMU-MOSI dataset, Acc-7 and Corr reached 50.96% and 0.895, respectively, while on the CMU-MOSEI dataset, Acc-7 and Corr reached 54.98% and 0.821. At the same time, the model has only 1.38M parameters, achieving a collaborative optimization of high performance and lightweight design.</div></div>","PeriodicalId":7484,"journal":{"name":"alexandria engineering journal","volume":"134 ","pages":"Pages 447-459"},"PeriodicalIF":6.8,"publicationDate":"2025-12-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145788023","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-12-18DOI: 10.1016/j.aej.2025.12.023
Hanan M. Alghamdi
Lung cancer is a major global health problem and early detection is crucial to prevent serious health problems. Analyzing affected areas manually is difficult and requires skilled physicians. To help with this, AI tools have been developed for automated lung cancer detection. This paper proposes a novel method for detecting lung cancer using deep learning techniques. It uses two specific deep learning models, EfficientNet-b0 and InceptionResNet-V2, to compute important features from lung images. The EfficientNet-b0 model is adjusted by replacing certain layers to improve its performance in lung cancer data. After extracting the characteristics, a specially designed genetic algorithm helps select the most useful characteristics, reducing unnecessary features, and making the system more efficient. The improved GA reduces more than 50% of features without interfering with the recognition results. The proposed approach is validated on two publicly available datasets, the CT Scan Images for Lung Cancer Dataset and the IQ-OTH/NCCD Dataset, achieving a classification precision of 99.50% and 99.20%, respectively. Our approach achieved 0.5 to 2.5% higher accuracy in comparison to state-of-the-art methods while reducing the dimensionality of the features by more than 50%, without affecting the classification performance. The improved genetic algorithm smartly chooses key features, thus accelerating processing and lowering costs. It proves valuable in real-time medical applications and automated lung cancer detection, supporting early diagnosis and treatment planning.
{"title":"Enhanced genetic algorithm-optimized deep learning features for lung cancer classification","authors":"Hanan M. Alghamdi","doi":"10.1016/j.aej.2025.12.023","DOIUrl":"10.1016/j.aej.2025.12.023","url":null,"abstract":"<div><div>Lung cancer is a major global health problem and early detection is crucial to prevent serious health problems. Analyzing affected areas manually is difficult and requires skilled physicians. To help with this, AI tools have been developed for automated lung cancer detection. This paper proposes a novel method for detecting lung cancer using deep learning techniques. It uses two specific deep learning models, EfficientNet-b0 and InceptionResNet-V2, to compute important features from lung images. The EfficientNet-b0 model is adjusted by replacing certain layers to improve its performance in lung cancer data. After extracting the characteristics, a specially designed genetic algorithm helps select the most useful characteristics, reducing unnecessary features, and making the system more efficient. The improved GA reduces more than 50% of features without interfering with the recognition results. The proposed approach is validated on two publicly available datasets, the CT Scan Images for Lung Cancer Dataset and the IQ-OTH/NCCD Dataset, achieving a classification precision of 99.50% and 99.20%, respectively. Our approach achieved 0.5 to 2.5% higher accuracy in comparison to state-of-the-art methods while reducing the dimensionality of the features by more than 50%, without affecting the classification performance. The improved genetic algorithm smartly chooses key features, thus accelerating processing and lowering costs. It proves valuable in real-time medical applications and automated lung cancer detection, supporting early diagnosis and treatment planning.</div></div>","PeriodicalId":7484,"journal":{"name":"alexandria engineering journal","volume":"134 ","pages":"Pages 341-357"},"PeriodicalIF":6.8,"publicationDate":"2025-12-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145787963","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-12-18DOI: 10.1016/j.aej.2025.12.021
Zainab M.H. El-Qahtani , Fadhel Almalki , Tahani Al-Mutairi , Ali Algarni , Tahani M. Albogami , E.A.-B. Abdel-Salam
This paper investigates the nonlinear dynamics of IASW and periodic waves in warm-ion, isothermal-electron plasmas using the stfKdV equation. Exact analytical solutions are obtained through the F-expansion and Hirota’s bilinear approaches, yielding solitary, cnoidal, and multi-soliton waveforms. The effects of the fractional order α and the ion-to-electron temperature ratio σ are systematically analyzed: α regulates the effective dispersive spreading and phase evolution of the waves, while σ controls amplitude and spatial width through its influence on the nonlinear and dispersive coefficients. Phase-portrait and bifurcation analyses reveal the existence of solitary, periodic, and shock-type structures, and demonstrate how fractional-order dispersion alters the topology of the associated dynamical system. The novelties of this work lie in providing a unified analytical and dynamical framework for the stfKdV model and clarifying how α and σ jointly shape soliton morphology and interaction properties. The research enhances the theoretical framework of fractional nonlinear wave models and offers insights applicable to laboratory and space plasmas, as well as other dispersive environments where fractional-order descriptions remain effective.
{"title":"Nonlinear space–time fractional KdV model for ion-acoustic shock waves in isothermal-electron, warm-ion plasmas","authors":"Zainab M.H. El-Qahtani , Fadhel Almalki , Tahani Al-Mutairi , Ali Algarni , Tahani M. Albogami , E.A.-B. Abdel-Salam","doi":"10.1016/j.aej.2025.12.021","DOIUrl":"10.1016/j.aej.2025.12.021","url":null,"abstract":"<div><div>This paper investigates the nonlinear dynamics of IASW and periodic waves in warm-ion, isothermal-electron plasmas using the stfKdV equation. Exact analytical solutions are obtained through the F-expansion and Hirota’s bilinear approaches, yielding solitary, cnoidal, and multi-soliton waveforms. The effects of the fractional order α and the ion-to-electron temperature ratio σ are systematically analyzed: α regulates the effective dispersive spreading and phase evolution of the waves, while σ controls amplitude and spatial width through its influence on the nonlinear and dispersive coefficients. Phase-portrait and bifurcation analyses reveal the existence of solitary, periodic, and shock-type structures, and demonstrate how fractional-order dispersion alters the topology of the associated dynamical system. The novelties of this work lie in providing a unified analytical and dynamical framework for the stfKdV model and clarifying how α and σ jointly shape soliton morphology and interaction properties. The research enhances the theoretical framework of fractional nonlinear wave models and offers insights applicable to laboratory and space plasmas, as well as other dispersive environments where fractional-order descriptions remain effective.</div></div>","PeriodicalId":7484,"journal":{"name":"alexandria engineering journal","volume":"134 ","pages":"Pages 358-374"},"PeriodicalIF":6.8,"publicationDate":"2025-12-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145787964","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-12-17DOI: 10.1016/j.aej.2025.12.020
Miao Xu , Lizeng Zhang , Peiyu Hou
As vehicles become increasingly interconnected with networks, not only does communication between onboard systems grow more frequent, but real-time interactions between these systems and external infrastructure also significantly increase. Although these complex interactions promote the development of intelligent transportation, they also greatly increase the attack surface. In the face of such a background, identifying abnormal vehicle behavior in time becomes crucial to driving safety. The current anomaly detection methods cannot fully reflect the semantic information in the vehicle data. Without the knowledge of the logical relation of messages, models are very likely to produce a large amount of false positives, and it is difficult to explain the decision-making basis. To alleviate the above issues, we propose a learnable graph-based differential equation anomaly detection framework (LGOVAD) for CAN-FD vehicle networks. LGOVAD consists of three fundamental modules, which work cooperatively to interpretable and model the semantic dynamics of vehicle communication data. The Semantic Extractor decodes interpretable physical signals based on the raw CAN messages. Then the Semantic Relationship Perception module discovers the hidden dependencies between vehicle parameters dynamically by employing a dual-branch graph learning strategy. Finally, we use a graph ODE network to capture the evolution process of these semantic patterns over time in a continuous manner. Experiments on real CAN-FD datasets demonstrate LGOVAD’s ability to accurately identify semantic and temporal anomalies triggered by attack messages. Additionally, we validate the model’s cross-domain generalization capabilities on SWaT and WADI datasets. Specifically, on CAN-FD data, LGOVAD achieves F1 scores 1.27-11.51% higher than specialized in-vehicle detectors (CANet, CANShield, PSEAD) and 3.48-16.42% higher than general multivariate temporal methods (GTA, FuGLAD). while maintaining robust advantages in normalized F1 scores on industrial benchmarks (SWaT, WADI).
{"title":"Learnable graph ODE networks for anomaly detection in CAN-FD vehicle networks","authors":"Miao Xu , Lizeng Zhang , Peiyu Hou","doi":"10.1016/j.aej.2025.12.020","DOIUrl":"10.1016/j.aej.2025.12.020","url":null,"abstract":"<div><div>As vehicles become increasingly interconnected with networks, not only does communication between onboard systems grow more frequent, but real-time interactions between these systems and external infrastructure also significantly increase. Although these complex interactions promote the development of intelligent transportation, they also greatly increase the attack surface. In the face of such a background, identifying abnormal vehicle behavior in time becomes crucial to driving safety. The current anomaly detection methods cannot fully reflect the semantic information in the vehicle data. Without the knowledge of the logical relation of messages, models are very likely to produce a large amount of false positives, and it is difficult to explain the decision-making basis. To alleviate the above issues, we propose a learnable graph-based differential equation anomaly detection framework (LGOVAD) for CAN-FD vehicle networks. LGOVAD consists of three fundamental modules, which work cooperatively to interpretable and model the semantic dynamics of vehicle communication data. The Semantic Extractor decodes interpretable physical signals based on the raw CAN messages. Then the Semantic Relationship Perception module discovers the hidden dependencies between vehicle parameters dynamically by employing a dual-branch graph learning strategy. Finally, we use a graph ODE network to capture the evolution process of these semantic patterns over time in a continuous manner. Experiments on real CAN-FD datasets demonstrate LGOVAD’s ability to accurately identify semantic and temporal anomalies triggered by attack messages. Additionally, we validate the model’s cross-domain generalization capabilities on SWaT and WADI datasets. Specifically, on CAN-FD data, LGOVAD achieves F1 scores 1.27-11.51% higher than specialized in-vehicle detectors (CANet, CANShield, PSEAD) and 3.48-16.42% higher than general multivariate temporal methods (GTA, FuGLAD). while maintaining robust advantages in normalized F1 scores on industrial benchmarks (SWaT, WADI).</div></div>","PeriodicalId":7484,"journal":{"name":"alexandria engineering journal","volume":"134 ","pages":"Pages 308-320"},"PeriodicalIF":6.8,"publicationDate":"2025-12-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145788019","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-12-17DOI: 10.1016/j.aej.2025.12.024
Haiyang Yu , Hong Yu , Wei Wang , Kai Fang , Xiaotong Zhang , Han Liu
Knowledge Graphs (KGs) are vital for structured knowledge but suffer from intrinsic incompleteness. Knowledge Graph Completion (KGC) faces a critical trade-off between the performance of ”black-box” models and the interpretability of explainable approaches that rely on purely symbolic structures. To resolve this, we propose the Explainable Path Reasoning (EPR) framework, which synergizes statistical topology analysis with deep semantic modeling. EPR first mines a corpus of statistically-grounded reasoning paths using a hop-normalized conditional likelihood to mitigate length bias. This corpus is then used to train a powerful BERT encoder via a path-level contrastive objective, teaching it to comprehend compositional semantics. For inference, a single, unified BERT architecture powers a dynamic beam search, performing the dual role of scoring candidates for prediction and constructing faithful, multi-hop explanations. Experimental results demonstrate that EPR establishes a new competitive performance among explainable methods and significantly narrows the performance gap to leading black-box models, providing a powerful and transparent solution for KGC, which is essential for trustworthy decision-making in intelligent communication systems.
{"title":"An explainable path reasoning framework for knowledge graph completion","authors":"Haiyang Yu , Hong Yu , Wei Wang , Kai Fang , Xiaotong Zhang , Han Liu","doi":"10.1016/j.aej.2025.12.024","DOIUrl":"10.1016/j.aej.2025.12.024","url":null,"abstract":"<div><div>Knowledge Graphs (KGs) are vital for structured knowledge but suffer from intrinsic incompleteness. Knowledge Graph Completion (KGC) faces a critical trade-off between the performance of ”black-box” models and the interpretability of explainable approaches that rely on purely symbolic structures. To resolve this, we propose the Explainable Path Reasoning (EPR) framework, which synergizes statistical topology analysis with deep semantic modeling. EPR first mines a corpus of statistically-grounded reasoning paths using a hop-normalized conditional likelihood to mitigate length bias. This corpus is then used to train a powerful BERT encoder via a path-level contrastive objective, teaching it to comprehend compositional semantics. For inference, a single, unified BERT architecture powers a dynamic beam search, performing the dual role of scoring candidates for prediction and constructing faithful, multi-hop explanations. Experimental results demonstrate that EPR establishes a new competitive performance among explainable methods and significantly narrows the performance gap to leading black-box models, providing a powerful and transparent solution for KGC, which is essential for trustworthy decision-making in intelligent communication systems.</div></div>","PeriodicalId":7484,"journal":{"name":"alexandria engineering journal","volume":"134 ","pages":"Pages 321-328"},"PeriodicalIF":6.8,"publicationDate":"2025-12-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145788020","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-12-17DOI: 10.1016/j.aej.2025.12.009
Abdulilah Mohammad Mayet
The ability to accurately calculate volumetric fractions for three-phase flow: gas, water and oil, is critical for industrial applications in the oil and gas and chemical engineering industry. This paper develops a methodology that incorporates the acquisition of signals using X-rays, spectral features and machine learning. Spectral features representing mean energy, variance, full width at half maximum (FWHM), entropy, kurtosis, and cepstral coefficients, were obtained from 108 Monte Carlo N-Particle (MCNP) energy simulation sets through annular, homogeneous and stratified flow regimes and 36 combinations of volume fractions ranging from 10 % to 80 %. The Beetle Antennae Search (BAS) algorithm optimizes the spectral features using measures that reduce the number of features to six features to improve overall prediction efficiency, these six features are the final input for a lightweight convolutional neural network (CNN). The chosen samples from the MCNP simulations (86 samples for training input and 22 for testing input, referred to as "the dataset") were used for training and testing the model in order to predict the three volume fractions. The predictions resulted in low root mean square error (RMSE) values, documented as 0.15 for gas, 0.13 for water and 0.14 for oil with R² values all exceeding 0.94; residuals were assessed to determine the model's stability and showed that the residuals were clustered around 0 for both training and testing sets. This approach offers a real-time and computationally-efficient technique for use in industry, but the reliance on simulated data and number of existing samples means there is still room for improvement in the future. The study demonstrates a scalable method for multiphase flow analysis, which could be verified with real experimental data in future studies to improve on the overall detection method reliability.
{"title":"Optimized spectral feature selection with lightweight CNN for precise volume fraction estimation in three-phase flows","authors":"Abdulilah Mohammad Mayet","doi":"10.1016/j.aej.2025.12.009","DOIUrl":"10.1016/j.aej.2025.12.009","url":null,"abstract":"<div><div>The ability to accurately calculate volumetric fractions for three-phase flow: gas, water and oil, is critical for industrial applications in the oil and gas and chemical engineering industry. This paper develops a methodology that incorporates the acquisition of signals using X-rays, spectral features and machine learning. Spectral features representing mean energy, variance, full width at half maximum (FWHM), entropy, kurtosis, and cepstral coefficients, were obtained from 108 Monte Carlo N-Particle (MCNP) energy simulation sets through annular, homogeneous and stratified flow regimes and 36 combinations of volume fractions ranging from 10 % to 80 %. The Beetle Antennae Search (BAS) algorithm optimizes the spectral features using measures that reduce the number of features to six features to improve overall prediction efficiency, these six features are the final input for a lightweight convolutional neural network (CNN). The chosen samples from the MCNP simulations (86 samples for training input and 22 for testing input, referred to as \"the dataset\") were used for training and testing the model in order to predict the three volume fractions. The predictions resulted in low root mean square error (RMSE) values, documented as 0.15 for gas, 0.13 for water and 0.14 for oil with R² values all exceeding 0.94; residuals were assessed to determine the model's stability and showed that the residuals were clustered around 0 for both training and testing sets. This approach offers a real-time and computationally-efficient technique for use in industry, but the reliance on simulated data and number of existing samples means there is still room for improvement in the future. The study demonstrates a scalable method for multiphase flow analysis, which could be verified with real experimental data in future studies to improve on the overall detection method reliability.</div></div>","PeriodicalId":7484,"journal":{"name":"alexandria engineering journal","volume":"134 ","pages":"Pages 329-340"},"PeriodicalIF":6.8,"publicationDate":"2025-12-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145788027","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-12-15DOI: 10.1016/j.aej.2025.12.002
Dong Li , Xiaoqing Wang , Jinglan Zhao , Meina Shi , Baoyi Chen , Guifang Su
Lung cancer remains a leading cause of cancer mortality, with drug resistance contributing to over 90 % of therapeutic failures in advanced cases. This review systematically examines how engineered nanoparticles can address the multifaceted mechanisms of resistance—including genetic mutations, efflux transporter overexpression, tumor microenvironment alterations, and stemness-associated phenotypes. Nanocarriers such as liposomes, polymeric nanoparticles, solid lipid nanoparticles, dendrimers, and inorganic particles have demonstrated enhanced tumor accumulation, prolonged circulation, and triggered intracellular release. In multidrug-resistant models, these formulations reduced doxorubicin IC50 values by up to 90 % and restored sensitivity to paclitaxel and cisplatin. Key strategies include co-delivering chemotherapeutics with agents like siRNA or modulators, achieving significant tumor shrinkage and re-sensitization, and employing stimuli-responsive designs for precise payload release at tumor sites, thereby reducing systemic toxicity. Organelle-targeted delivery (mitochondria, nuclei) further enhances efficacy against resistant subpopulations. In preclinical settings, these strategies have not only achieved tumor regression but also reduced metastases and improved overall survival. The integration of active targeting ligands and immunomodulatory agents positions nanoparticle platforms as multifunctional systems with substantial translational potential. This review highlights the engineering innovations that enable precise delivery, effective drug release, and circumvention of resistance in lung cancer models.
{"title":"The application development of nanoparticle-based drug delivery systems in combating drug resistance of lung cancer","authors":"Dong Li , Xiaoqing Wang , Jinglan Zhao , Meina Shi , Baoyi Chen , Guifang Su","doi":"10.1016/j.aej.2025.12.002","DOIUrl":"10.1016/j.aej.2025.12.002","url":null,"abstract":"<div><div>Lung cancer remains a leading cause of cancer mortality, with drug resistance contributing to over 90 % of therapeutic failures in advanced cases. This review systematically examines how engineered nanoparticles can address the multifaceted mechanisms of resistance—including genetic mutations, efflux transporter overexpression, tumor microenvironment alterations, and stemness-associated phenotypes. Nanocarriers such as liposomes, polymeric nanoparticles, solid lipid nanoparticles, dendrimers, and inorganic particles have demonstrated enhanced tumor accumulation, prolonged circulation, and triggered intracellular release. In multidrug-resistant models, these formulations reduced doxorubicin IC50 values by up to 90 % and restored sensitivity to paclitaxel and cisplatin. Key strategies include co-delivering chemotherapeutics with agents like siRNA or modulators, achieving significant tumor shrinkage and re-sensitization, and employing stimuli-responsive designs for precise payload release at tumor sites, thereby reducing systemic toxicity. Organelle-targeted delivery (mitochondria, nuclei) further enhances efficacy against resistant subpopulations. In preclinical settings, these strategies have not only achieved tumor regression but also reduced metastases and improved overall survival. The integration of active targeting ligands and immunomodulatory agents positions nanoparticle platforms as multifunctional systems with substantial translational potential. This review highlights the engineering innovations that enable precise delivery, effective drug release, and circumvention of resistance in lung cancer models.</div></div>","PeriodicalId":7484,"journal":{"name":"alexandria engineering journal","volume":"134 ","pages":"Pages 275-307"},"PeriodicalIF":6.8,"publicationDate":"2025-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145788021","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-12-15DOI: 10.1016/j.aej.2025.12.018
Ahmed H. Shahein, Mohammed Ghazy, Atef A. Ata
In the last decades the Meta-heuristics and evolution algorithms were used in designing the optimal trajectory planning. These algorithms mimic the intelligence of the nature to optimize the trajectory planning under certain constraints. In this paper the Meta-Heuristics algorithms like Adaptive Particles Swarm Optimization APSO and Genetic Algorithms are used under certain constraints to make the robot interacts efficiently and effectively. Also obstacle avoidance will be investigated by driving the robot to acquire artificial intuition using potential field theory. In this study we managed to design a free collision optimum trajectory planning with minimum tracking error using APSO compared with GA. For the same degree of accuracy, the Adaptive Particle Swarm Optimization (APSO) provides faster convergence rate and reduces the computational time compared to GA. The integration of Artificial potential field theory enables us to know how to generate a free collision path to the end effector. The proposed APSO algorithm ensures that none of robot links intercepts with the obstacles during the course of motion, also offering excellent convergence and minimum error compared with other techniques.
{"title":"Optimal trajectory planning of 6 DOF manipulator using meta- heuristics integrated with artificial potential field theory","authors":"Ahmed H. Shahein, Mohammed Ghazy, Atef A. Ata","doi":"10.1016/j.aej.2025.12.018","DOIUrl":"10.1016/j.aej.2025.12.018","url":null,"abstract":"<div><div>In the last decades the Meta-heuristics and evolution algorithms were used in designing the optimal trajectory planning. These algorithms mimic the intelligence of the nature to optimize the trajectory planning under certain constraints. In this paper the Meta-Heuristics algorithms like Adaptive Particles Swarm Optimization APSO and Genetic Algorithms are used under certain constraints to make the robot interacts efficiently and effectively. Also obstacle avoidance will be investigated by driving the robot to acquire artificial intuition using potential field theory. In this study we managed to design a free collision optimum trajectory planning with minimum tracking error using APSO compared with GA. For the same degree of accuracy, the Adaptive Particle Swarm Optimization (APSO) provides faster convergence rate and reduces the computational time compared to GA. The integration of Artificial potential field theory enables us to know how to generate a free collision path to the end effector. The proposed APSO algorithm ensures that none of robot links intercepts with the obstacles during the course of motion, also offering excellent convergence and minimum error compared with other techniques.</div></div>","PeriodicalId":7484,"journal":{"name":"alexandria engineering journal","volume":"134 ","pages":"Pages 263-274"},"PeriodicalIF":6.8,"publicationDate":"2025-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145788018","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Due to the challenges faced by current deep learning models in training, such as incomplete data coverage and difficulty in fully reflecting all actual scenarios, this study explores innovative approaches to data collection and annotation strategies. The aim is to fundamentally solve the problem of performance degradation of models in unknown scenarios by improving data diversity and quality. A refined data collection framework has been designed, combined with feature extraction and representation methods in dynamic scenes, effectively enhancing the adaptability and robustness of the model. In order to further verify the effectiveness of the strategy, this study introduces the Visual Auxiliary Graph Neural Network (VA-GNN) and constructs an innovative model for collaborative control of intelligent transportation systems. The experimental results show that with the increase of training iterations, the VA-GNN model and collaborative control strategy have achieved significant results in reducing the average waiting time of vehicles and the number of vehicles in the same lane queue, which is a qualitative leap compared to traditional methods.
{"title":"Vision-assisted graph neural network for collaborative control in intelligent transportation systems","authors":"Shanqian Lin , Xincheng Wu , Jing Zhao , Xiaohong Zhuang","doi":"10.1016/j.aej.2025.12.006","DOIUrl":"10.1016/j.aej.2025.12.006","url":null,"abstract":"<div><div>Due to the challenges faced by current deep learning models in training, such as incomplete data coverage and difficulty in fully reflecting all actual scenarios, this study explores innovative approaches to data collection and annotation strategies. The aim is to fundamentally solve the problem of performance degradation of models in unknown scenarios by improving data diversity and quality. A refined data collection framework has been designed, combined with feature extraction and representation methods in dynamic scenes, effectively enhancing the adaptability and robustness of the model. In order to further verify the effectiveness of the strategy, this study introduces the Visual Auxiliary Graph Neural Network (VA-GNN) and constructs an innovative model for collaborative control of intelligent transportation systems. The experimental results show that with the increase of training iterations, the VA-GNN model and collaborative control strategy have achieved significant results in reducing the average waiting time of vehicles and the number of vehicles in the same lane queue, which is a qualitative leap compared to traditional methods.</div></div>","PeriodicalId":7484,"journal":{"name":"alexandria engineering journal","volume":"134 ","pages":"Pages 253-262"},"PeriodicalIF":6.8,"publicationDate":"2025-12-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145735272","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}