Pub Date : 2022-12-02DOI: 10.1176/appi.ajp-rj.2022.180207
Dennis E. Curry, B. L. Richards
{"title":"A Brief Review of Quetiapine","authors":"Dennis E. Curry, B. L. Richards","doi":"10.1176/appi.ajp-rj.2022.180207","DOIUrl":"https://doi.org/10.1176/appi.ajp-rj.2022.180207","url":null,"abstract":"","PeriodicalId":74938,"journal":{"name":"The American journal of psychiatry residents' journal","volume":"12 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-12-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87535113","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-12-02DOI: 10.1176/appi.ajp-rj.2022.180205
S. Poos, Kaitlin McGowan
{"title":"Diabulimia in a 23-Year-Old Woman With Multiple Comorbid Conditions","authors":"S. Poos, Kaitlin McGowan","doi":"10.1176/appi.ajp-rj.2022.180205","DOIUrl":"https://doi.org/10.1176/appi.ajp-rj.2022.180205","url":null,"abstract":"","PeriodicalId":74938,"journal":{"name":"The American journal of psychiatry residents' journal","volume":"6 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-12-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72829421","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-12-01DOI: 10.1176/appi.ajp.22179010
{"title":"Reviewers for The American Journal of Psychiatry.","authors":"","doi":"10.1176/appi.ajp.22179010","DOIUrl":"https://doi.org/10.1176/appi.ajp.22179010","url":null,"abstract":"","PeriodicalId":74938,"journal":{"name":"The American journal of psychiatry residents' journal","volume":"244 1","pages":"970-973"},"PeriodicalIF":0.0,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75845634","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-12-01DOI: 10.1176/appi.ajp.973correction
{"title":"Correction.","authors":"","doi":"10.1176/appi.ajp.973correction","DOIUrl":"https://doi.org/10.1176/appi.ajp.973correction","url":null,"abstract":"","PeriodicalId":74938,"journal":{"name":"The American journal of psychiatry residents' journal","volume":"11 1","pages":"973"},"PeriodicalIF":0.0,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87883536","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-10-01Epub Date: 2022-06-15DOI: 10.1176/appi.ajp.21090964
Didier Jutras-Aswad, Bernard Le Foll, Keith Ahamad, Ron Lim, Julie Bruneau, Benedikt Fischer, Jürgen Rehm, T Cameron Wild, Evan Wood, Suzanne Brissette, Lea Gagnon, Jill Fikowski, Omar Ledjiar, Benoit Masse, M Eugenia Socias
Objective: Extensive exposure to prescription-type opioids has resulted in major harm worldwide, calling for better-adapted approaches to opioid agonist therapy. The authors aimed to determine whether flexible take-home buprenorphine/naloxone is as effective as supervised methadone in reducing opioid use in prescription-type opioid consumers with opioid use disorder.
Methods: This seven-site, pan-Canadian, 24-week, pragmatic, open-label, noninferiority, two-arm parallel randomized controlled trial involved treatment-seeking adults with prescription-type opioid use disorder. Participants were randomized in a 1:1 ratio to treatment with sublingual buprenorphine/naloxone (target dosage, 8 mg/2 mg to 24 mg/6 mg per day; flexible take-home dosing) or oral methadone (≈60-120 mg/day; closely supervised). The primary outcome was the proportion of opioid-free urine drug screens over 24 weeks (noninferiority margin, 15%). All randomized participants were analyzed, excluding one who died shortly after randomization, for the primary analysis (modified intention-to-treat analysis).
Results: Of 272 participants recruited (mean age, 39 years [SD=11]; 34.2% female), 138 were randomized to buprenorphine/naloxone and 134 to methadone. The mean proportion of opioid-free urine drug screens was 24.0% (SD=34.4) in the buprenorphine/naloxone group and 18.5% (SD=30.5) in the methadone group, with a 5.6% adjusted mean difference (95% CI=-0.3, +∞). Participants in the buprenorphine/naloxone group had 0.47 times the odds (95% CI=0.24, 0.90) of being retained in the assigned treatment compared with those in the methadone group. Overall, 24 drug-related adverse events were reported (12 in the buprenorphine/naloxone group [N=8/138; 5.7%] and 12 in the methadone group [N=12/134; 9.0%]) and mostly included withdrawal, hypogonadism, and overdose.
Conclusions: The buprenorphine/naloxone flexible model of care was safe and noninferior to methadone in reducing opioid use among people with prescription-type opioid use disorder. This flexibility could help expand access to opioid agonist therapy and reduce harms in the context of the opioid overdose crisis.
{"title":"Flexible Buprenorphine/Naloxone Model of Care for Reducing Opioid Use in Individuals With Prescription-Type Opioid Use Disorder: An Open-Label, Pragmatic, Noninferiority Randomized Controlled Trial.","authors":"Didier Jutras-Aswad, Bernard Le Foll, Keith Ahamad, Ron Lim, Julie Bruneau, Benedikt Fischer, Jürgen Rehm, T Cameron Wild, Evan Wood, Suzanne Brissette, Lea Gagnon, Jill Fikowski, Omar Ledjiar, Benoit Masse, M Eugenia Socias","doi":"10.1176/appi.ajp.21090964","DOIUrl":"10.1176/appi.ajp.21090964","url":null,"abstract":"<p><strong>Objective: </strong>Extensive exposure to prescription-type opioids has resulted in major harm worldwide, calling for better-adapted approaches to opioid agonist therapy. The authors aimed to determine whether flexible take-home buprenorphine/naloxone is as effective as supervised methadone in reducing opioid use in prescription-type opioid consumers with opioid use disorder.</p><p><strong>Methods: </strong>This seven-site, pan-Canadian, 24-week, pragmatic, open-label, noninferiority, two-arm parallel randomized controlled trial involved treatment-seeking adults with prescription-type opioid use disorder. Participants were randomized in a 1:1 ratio to treatment with sublingual buprenorphine/naloxone (target dosage, 8 mg/2 mg to 24 mg/6 mg per day; flexible take-home dosing) or oral methadone (≈60-120 mg/day; closely supervised). The primary outcome was the proportion of opioid-free urine drug screens over 24 weeks (noninferiority margin, 15%). All randomized participants were analyzed, excluding one who died shortly after randomization, for the primary analysis (modified intention-to-treat analysis).</p><p><strong>Results: </strong>Of 272 participants recruited (mean age, 39 years [SD=11]; 34.2% female), 138 were randomized to buprenorphine/naloxone and 134 to methadone. The mean proportion of opioid-free urine drug screens was 24.0% (SD=34.4) in the buprenorphine/naloxone group and 18.5% (SD=30.5) in the methadone group, with a 5.6% adjusted mean difference (95% CI=-0.3, +∞). Participants in the buprenorphine/naloxone group had 0.47 times the odds (95% CI=0.24, 0.90) of being retained in the assigned treatment compared with those in the methadone group. Overall, 24 drug-related adverse events were reported (12 in the buprenorphine/naloxone group [N=8/138; 5.7%] and 12 in the methadone group [N=12/134; 9.0%]) and mostly included withdrawal, hypogonadism, and overdose.</p><p><strong>Conclusions: </strong>The buprenorphine/naloxone flexible model of care was safe and noninferior to methadone in reducing opioid use among people with prescription-type opioid use disorder. This flexibility could help expand access to opioid agonist therapy and reduce harms in the context of the opioid overdose crisis.</p>","PeriodicalId":74938,"journal":{"name":"The American journal of psychiatry residents' journal","volume":"1 1","pages":"726-739"},"PeriodicalIF":0.0,"publicationDate":"2022-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80178668","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-10-01DOI: 10.1176/appi.ajp.22179003
{"title":"Reports to the Membership.","authors":"","doi":"10.1176/appi.ajp.22179003","DOIUrl":"https://doi.org/10.1176/appi.ajp.22179003","url":null,"abstract":"","PeriodicalId":74938,"journal":{"name":"The American journal of psychiatry residents' journal","volume":"35 1","pages":"768-780"},"PeriodicalIF":0.0,"publicationDate":"2022-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82324516","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-09-08DOI: 10.1176/appi.ajp-rj.2022.180109
Johnathan Wu
{"title":"Seeing Through the Eyes of Another: A Brief Review of the 2020 Film “The Father”","authors":"Johnathan Wu","doi":"10.1176/appi.ajp-rj.2022.180109","DOIUrl":"https://doi.org/10.1176/appi.ajp-rj.2022.180109","url":null,"abstract":"","PeriodicalId":74938,"journal":{"name":"The American journal of psychiatry residents' journal","volume":"18 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-09-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78008265","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-09-08DOI: 10.1176/appi.ajp-rj.2022.180107
L. Simeon-Thompson, Maia L. Ou
{"title":"Antiracism in Mixed Spaces","authors":"L. Simeon-Thompson, Maia L. Ou","doi":"10.1176/appi.ajp-rj.2022.180107","DOIUrl":"https://doi.org/10.1176/appi.ajp-rj.2022.180107","url":null,"abstract":"","PeriodicalId":74938,"journal":{"name":"The American journal of psychiatry residents' journal","volume":"2010 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-09-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86304814","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-09-08DOI: 10.1176/appi.ajp-rj.2022.180104
Emma Banasiak
{"title":"The Role of Gender Dysphoria in the Development of an Eating Disorder","authors":"Emma Banasiak","doi":"10.1176/appi.ajp-rj.2022.180104","DOIUrl":"https://doi.org/10.1176/appi.ajp-rj.2022.180104","url":null,"abstract":"","PeriodicalId":74938,"journal":{"name":"The American journal of psychiatry residents' journal","volume":"50 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-09-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90802770","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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