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Abstracts of scientific presentations at the 2016 Annual National Conference of the Critical Care Society of Southern Africa 2016年南非重症监护学会年度全国会议科学报告摘要
L. Michell
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引用次数: 0
Physiotherapy in the intensive care unit 加护病房的物理治疗
S. Hanekom
While physiotherapy has been recommended by scientific societies as integral to the management of critically ill patients, great variation has been reported in the role of the physiotherapist in the intensive care unit (ICU), the service provided and the techniques used.[1] Clearly, this may impact on patient outcome. In a bid to address these variations, ICU physiotherapists have taken the initiative to drive a research agenda and to standardise clinical pathways to facilitate optimal patient outcome.
虽然物理治疗已被科学协会推荐为管理危重患者不可或缺的一部分,但据报道,在重症监护病房(ICU)物理治疗师的角色、提供的服务和使用的技术方面存在很大差异。[1]显然,这可能会影响患者的预后。为了解决这些差异,ICU物理治疗师已经主动推动研究议程,并标准化临床途径,以促进最佳的患者结果。
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引用次数: 18
Comparison of the efficacy of colistin monotherapy and colistin combination therapies in the treatment of nosocomial pneumonia and ventilator-associated pneumonia caused by Acinetobacter baumannii 粘菌素单药与联合治疗鲍曼不动杆菌引起的院内性肺炎和呼吸机相关性肺炎的疗效比较
I. Kara, F. Yıldırım, B. Bilaloğlu, Dilek Karamanlıoğlu, Esra Kayacan, M. Dizbay, M. Turkoglu, G. Aygencel
Objective. To investigate whether there was a difference in mortality, clinical response and bacterial eradication between colistin monotherapy and colistin combination therapies for the treatment of nosocomial pneumonia/ventilator-associated pneumonia (VAP) caused by Acinetobacter baumannii in a medical intensive care unit (ICU).  Methods. This retrospective, observational and single-centre study included all patients who were in the medical ICU of Gazi University Medical Faculty Hospital and diagnosed with nosocomial pneumonia/VAP caused by A. baumannii between January 2009 and September 2014.  Results. The median age of the 134 patients was 68 years and 53.3% were male. The most common causes of admission were respiratory insufficiency (66.7%) and sepsis/septic shock (54.8%). In patients with nosocomial pneumonia/VAP caused by A. baumannii , on median day 5 of admission, colistin monotherapy was used in 23 (21.6%) patients, a carbapenem combination was used in 80 (59.7%) patients, sulbactam-ampicillin combination was used in 42 (31.4%) patients, tigecycline combination was used in 26 (19.4%) patients, and sulbactam-cefoperazone combination was used in 17 (12.7%) patients. Median ICU stay of the patients was 15.5 days, and 112 (83.6%) patients died. Colistin monotherapy and combination therapies had no superiority over each other in clinical response for the treatment of A. baumannii -associated nosocomial pneumonia/VAP. Mortality was found to be higher in patients receiving the colistin-carbapenem combination (64.3% v. 36.4%, p =0.016). Discharge/day-of-death Sequential Organ Failure Assessment score (odds ratio (OR) 2.017, 95% confidence interval (CI) 1.330 - 3.061) and vasopressor use (OR 9.014, 95% CI 1.360 - 59.464) were independent risk factors for ICU mortality. Conclusion. Colistin monotherapy and combination therapies have no superiority over each other for clinical response in the treatment of nosocomial pneumonia/VAP caused by multidrug-resistant A. baumannii . Colistin-SAM was associated with improved microbiological eradication and colistin-carbapenem combination was associated with increased mortality.
目标。探讨在重症监护病房(ICU)治疗由鲍曼不动杆菌引起的院内性肺炎/呼吸机相关性肺炎(VAP)时,粘菌素单药治疗与联合治疗在死亡率、临床反应和细菌根除方面是否存在差异。方法。这项回顾性、观察性、单中心研究纳入了2009年1月至2014年9月期间在加齐大学医学院附属医院内科ICU诊断为鲍曼不动杆菌引起的院内性肺炎/VAP的所有患者。结果。134例患者中位年龄为68岁,男性53.3%。最常见的入院原因是呼吸功能不全(66.7%)和脓毒症/感染性休克(54.8%)。鲍曼不动杆菌引起的院内肺炎/VAP患者中位入院第5天,23例(21.6%)患者使用粘菌素单药治疗,80例(59.7%)患者使用碳青霉烯类药物联合治疗,42例(31.4%)患者使用舒巴坦-氨苄西林联合治疗,26例(19.4%)患者使用替加环素联合治疗,17例(12.7%)患者使用舒巴坦-头孢哌酮联合治疗。患者住院时间中位数为15.5 d,死亡112例(83.6%)。粘菌素单药治疗和联合治疗在鲍曼不动杆菌相关医院性肺炎/VAP的临床疗效上没有优势。接受粘菌素-碳青霉烯联合治疗的患者死亡率更高(64.3% vs 36.4%, p =0.016)。出院/死亡当日顺序器官衰竭评估评分(优势比(OR) 2.017, 95%可信区间(CI) 1.330 ~ 3.061)和血管加压药使用(OR 9.014, 95% CI 1.360 ~ 59.464)是ICU死亡率的独立危险因素。结论。粘菌素单药治疗和联合治疗在治疗多药鲍曼不动杆菌引起的院内性肺炎/VAP的临床反应上没有优势。粘菌素- sam与改善微生物根除有关,粘菌素-碳青霉烯联合使用与死亡率增加有关。
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引用次数: 7
Cardiopulmonary Physiotherapy in Trauma: An Evidence-based Approach 创伤中的心肺物理治疗:循证方法
A. Lupton-Smith
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引用次数: 3
Moral distress experienced by intensive care nurses 重症监护护士经历的道德困境
G. Langley, Leah C Kisorio, S. Schmollgruber
Background. Moral distress is experienced when nurses experience conflict while making an ethical decision. This is magnified when the decisions are about withholding or withdrawing life-sustaining treatment. Objective. To explore and describe nurses’ experiences of situations that involve end-of-life care and evoke moral distress in the intensive care units (ICUs) of two public tertiary-level hospitals in South Africa (SA), the personal consequences of these situations and the means employed to manage their distress.  Methods. An exploratory, descriptive design was used. A short survey/interview guide was administered to registered and enrolled nurses ( N =100) employed in the ICUs from two academic-affiliated, specialist public hospitals.  Results. A total of 65 completed surveys were collected. Of these, 32 responses were judged not to be describing moral distress while 33 clearly described moral distress and were included and analysed by means of initial content analysis. The findings were presented in five major categories: ( i ) collegial incompetence or inexperience; ( ii ) resource constraints; ( iii ) end-of-life issues; ( iv ) lack of consultation, communication and negotiation; and ( v ) support.  Conclusion. The study found that nurses experienced considerable moral distress. This is compounded in an environment where gender, professional and social status inhibit the nurses’ assertiveness, ‘voice’ and influence in the healthcare system. Parallels can be drawn between the microcosm of the ICU and the macrocosm of the SA social and ethical character.
背景。当护士在做出道德决定时遇到冲突时,就会经历道德困境。当决定停止或撤销维持生命的治疗时,这种情况会被放大。目标。探索和描述护士在南非(SA)两家公立三级医院重症监护病房(icu)中涉及临终关怀和唤起道德痛苦的情况的经历,这些情况的个人后果以及用于管理其痛苦的手段。方法。采用探索性描述性设计。对两所附属专科公立医院icu的注册和登记护士(N =100)进行了简短的调查/访谈指南。结果。共收集了65份已完成的调查问卷。其中,32个回答被认为没有描述道德困境,而33个回答明确描述了道德困境,并通过初步内容分析被纳入和分析。调查结果分为五个主要类别:(i)大学教员不称职或缺乏经验;(ii)资源限制;(iii)生命终结问题;(四)缺乏协商、沟通和谈判;(v)支持。结论。研究发现,护士经历了相当大的道德困扰。在性别、专业和社会地位抑制护士在医疗保健系统中的自信、“声音”和影响力的环境中,这种情况更加复杂。在ICU的微观世界和SA的社会和伦理品格的宏观世界之间可以得出相似之处。
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引用次数: 18
Ethical considerations for critical care research 危重病研究的伦理考虑
B. Morrow
Ethical lapses are almost never a case of bad people, doing bad things, for no good reason. More often they are good people, doing bad things, for good reasons. (Marcia Angell, previous Editor-in-Chief (1988 - 2000), New England Journal of Medicine.) Critical illness carries high morbidity and mortality worldwide, with a disproportionate burden of critical illness in low- and middle-income countries, where access to intensive care is particularly limited. Without research in the intensive care unit (ICU) population, we are unlikely to improve our understanding of how to safely and effectively manage a wide range of diseases and injuries, minimise discomfort, reduce organ dysfunction, improve survival, improve quality of life in survivors of critical illness, and ensure rational and equitable use of scarce resources. Clinical research in the critical care environment is therefore essential to inform best practice ('evidence-based care').
道德沦丧几乎从来不是坏人无缘无故做坏事的情况。更多时候,他们是好人,出于正当理由做坏事。(马西娅·安吉尔,《新英格兰医学杂志》前主编(1988 - 2000)。)在世界范围内,危重疾病的发病率和死亡率都很高,低收入和中等收入国家的危重疾病负担过重,在这些国家获得重症监护的机会特别有限。如果没有对重症监护室(ICU)人群的研究,我们就不太可能提高我们对如何安全有效地管理各种疾病和损伤、最大限度地减少不适、减少器官功能障碍、提高生存率、改善危重疾病幸存者的生活质量以及确保合理和公平地使用稀缺资源的理解。因此,重症监护环境中的临床研究对于告知最佳实践(“循证护理”)至关重要。
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引用次数: 5
The accuracy of Johannesburg-based ambulance personnel in identifying stroke 约翰内斯堡救护人员识别中风的准确性
Devon Nel, W. Stassen
Background. Stroke is a potentially life-threatening, time-dependent event that requires urgent management to reduce morbidity and mortality. It has been suggested that earlier recognition by ambulance personnel and transport to stroke centres may significantly reduce treatment delays. For this reason it is vitally important that ambulance personnel are able to accurately diagnose stroke. Methods. A series of vignettes were created that included images, video and audio displaying either signs or symptoms of stroke or those of another condition. Ambulance personnel were asked to review each vignette and state whether the patient described was suffering from a stroke or not. Further investigation was sought by requesting each individual to motivate their answer, mentioning upon what their diagnosis was based.  Results. A total of 40 basic life support (BLS) and intermediate life support (ILS) personnel from different sites diagnosed 280 vignettes. BLS personnel were able to diagnose stroke with a sensitivity of 85.3% and a specificity of 89.9% (positive predictive value (PPV) 86.7%, negative predictive value (NPV) 88.8%), while ILS achieved a sensitivity of 98.2% and specificity of 94.0% (PPV 91.7%, NPV 98.8%). The combined sensitivity and specificity were 91.5% and 92.0%, respectively (PPV 89.2%, NPV 93.8%). In order to aid their diagnosis, only 5% of BLS and 18.34% of ILS utilised validated stroke screening tools. Conclusion. Despite not using validated screening tools, the ambulance personnel sampled in this study were able to identify stroke with high accuracy. Further studies should be considered to identify how these diagnoses were reached in order to identify training needs.
背景。中风是一种可能危及生命的时间依赖性事件,需要紧急管理以降低发病率和死亡率。有人建议,救护车人员的早期识别和运送到中风中心可能会显著减少治疗延误。因此,救护人员能够准确诊断中风是至关重要的。方法。他们制作了一系列的小插曲,包括图像、视频和音频,显示中风或其他疾病的迹象或症状。救护车人员被要求回顾每一个小插曲,并说明病人是否患有中风或没有。进一步的调查是通过要求每个人提出他们的答案,提到他们的诊断是基于什么。结果。来自不同地点的40名基本生命支持(BLS)和中级生命支持(ILS)人员共诊断了280个小病例。BLS人员诊断脑卒中的敏感性为85.3%,特异性为89.9%(阳性预测值(PPV) 86.7%,阴性预测值(NPV) 88.8%),而ILS的敏感性为98.2%,特异性为94.0% (PPV 91.7%, NPV 98.8%)。综合敏感性和特异性分别为91.5%和92.0% (PPV 89.2%, NPV 93.8%)。为了帮助诊断,只有5%的BLS和18.34%的ILS使用了有效的脑卒中筛查工具。结论。尽管没有使用经过验证的筛查工具,但在本研究中抽样的救护人员能够高精度地识别中风。应考虑进一步的研究,以确定这些诊断是如何达成的,以便确定培训需求。
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引用次数: 3
Atrial myxoma-related embolism resulting in acute limb ischaemia in a critical care patient 危重病患者心房黏液瘤相关栓塞导致急性肢体缺血
M. Knight, R. Wise
This report presents an unusual case of limb ischaemia in the critical care setting, the cause of which was elucidated on echocardiography. Evaluation of the case highlights the importance of appropriate and timely investigation, in particular the role of bedside echocardiography. Although atrial myxomas are uncommon, a thorough investigation of patients presenting with acute peripheral ischaemic events should be undertaken to facilitate the diagnosis of this treatable condition.
本报告提出一个不寻常的情况下肢体缺血在重症监护设置,其原因是阐明超声心动图。对病例的评估强调了适当和及时调查的重要性,特别是床边超声心动图的作用。虽然心房黏液瘤并不常见,但对出现急性外周缺血事件的患者应进行彻底的调查,以促进这种可治疗疾病的诊断。
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引用次数: 1
Nutrition support practices in South African ICUs: Results from a nationwide pilot survey 南非icu的营养支持实践:来自全国试点调查的结果
L. Hill
Background. Nutrition support of the critically ill can positively affect clinical outcomes. International audit data of nutrition practices in intensive care units (ICUs) suggest that inconsistent application of recommended nutrition support practices (NSPs) occurs. There are no data on NSPs in South African (SA) ICUs.  Objective. To perform a national pilot survey of NSPs in private SA adult ICUs.  Methods. A descriptive, observational, cross-sectional survey was performed among prescribers of nutrition support in private ICU facilities. Participants were targeted through non-randomised convenience sampling and invited to complete a 51-item electronic questionnaire covering ICU demographics, profile of nutrition prescribers, and nutrition assessment support, delivery and monitoring practices.  Results. Responses were received from 125 practitioners in 60% of representative private hospitals with ICU facilities, mainly general/mixed ICUs. Forty-six percent of respondents reported structured nutrition support teams and 61% reported that practices were governed by formal nutrition support protocols. Enteral nutrition was reported to be based upon published guidelines by 72% of dietitians, while parenteral nutrition decisions were reportedly based mainly on clinical judgement (43%). For both enteral and parenteral feeding practices, compliance with guidelines was inconsistent. There was a disjuncture between various NSPs as reported by dietitians and by nurses. Nurses generally appeared unaware of published nutrition guidelines.  Conclusion. Various disparities in reported nutrition practices were revealed, suggesting that the organisation and operations of teams and the implementation of protocols informed by published nutrition guidelines may not be well established in private SA ICUs.
背景。危重患者的营养支持对临床结果有积极影响。重症监护病房(icu)营养实践的国际审计数据表明,推荐营养支持实践(NSPs)的应用不一致。没有关于南非(SA) icu中nsp的数据。目标。对私立SA成人icu的nsp进行全国性试点调查。方法。一项描述性、观察性、横断面调查在私人ICU设施的营养支持处方者中进行。通过非随机方便抽样,参与者被邀请完成一份51项电子问卷,涵盖ICU人口统计、营养处方者概况、营养评估支持、交付和监测实践。结果。我们收到了来自60%设有ICU设施(主要是普通/混合ICU)的代表性私立医院的125名执业医生的回复。46%的答复者报告了有组织的营养支持小组,61%的答复者报告了由正式的营养支持协议管理的做法。据报道,72%的营养师根据已发表的指南进行肠内营养,而据报道,肠外营养的决定主要基于临床判断(43%)。对于肠内和肠外喂养的做法,遵守指南是不一致的。营养师和护士报告的各种nsp之间存在脱节。护士们似乎普遍不知道已公布的营养指南。结论。在报告的营养实践中发现了各种差异,表明小组的组织和运作以及根据已公布的营养指南通知的协议的实施可能没有很好地建立在私人SA icu中。
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引用次数: 3
Incidence and outcome of ventilator-associated pneumonia in Inkosi Albert Luthuli and King Edward VIII Hospital surgical intensive care units 英科西·阿尔伯特·卢图利和爱德华八世国王医院外科重症监护室呼吸机相关肺炎的发病率和结局
A. Behari, Nicky Kalafatis
Background. Ventilator-associated pneumonia (VAP) is one of the most common causes of hospital morbidity and mortality, but has been poorly studied in the South African context. Objective. To evaluate the incidence and outcome of VAP in the intensive care units (ICUs) of two major centres in the Durban metropolitan area. Methods. The study was conducted over a period of 6 months with all intubated and mechanically ventilated patients who were screened on admission to ICU. A questionnaire was prepared to note patients’ age, gender, date and time of intubation or reintubation. Patients were monitored from date of admission to the date of discharge from ICU or death. A diagnosis of VAP was made on a clinical pulmonary infection score (CPIS) of ≥6. Results. Of 32 patients evaluated, eight patients (25%) were diagnosed with VAP. Median duration of ventilation in the VAP group was 249 hours v. 65.5 hours in the non-VAP group ( p =0.0002). We found no statistically significant association between age or gender with the development of VAP ( p =0.28 and p =0.59, respectively). The most common organism isolated was Acinetobacter baumannii , followed by Pseudomonas aeruginosa . Three of the eight (37.5%) patients diagnosed with VAP died in the ICU. Conclusion. VAP is common in critically ill patients, possibly associated with poor outcome. These results highlight the need for strict adherence to evidence-based preventive measures.
背景。呼吸机相关性肺炎(VAP)是医院发病和死亡的最常见原因之一,但在南非的研究很少。目标。评估德班市区两个主要中心重症监护病房(icu) VAP的发生率和结果。方法。该研究在6个月的时间里对所有插管和机械通气的患者进行了筛选,这些患者在进入ICU时进行了筛选。准备一份问卷,记录患者的年龄、性别、插管或再插管的日期和时间。监测患者自入院至出院或死亡之日。临床肺部感染评分(CPIS)≥6时诊断为VAP。结果。在评估的32名患者中,8名患者(25%)被诊断为VAP。VAP组通气时间中位数为249小时,非VAP组为65.5小时(p =0.0002)。我们发现年龄或性别与VAP的发生无统计学意义的关联(分别为p =0.28和p =0.59)。最常见的细菌是鲍曼不动杆菌,其次是铜绿假单胞菌。诊断为VAP的8例患者中有3例(37.5%)死于ICU。结论。VAP常见于危重患者,可能与预后不良有关。这些结果突出了严格遵守以证据为基础的预防措施的必要性。
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引用次数: 5
期刊
The Southern African journal of critical care : the official journal of the Critical Care Society
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