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The needs of family members of intensive care unit patients : a grounded theory study 重症监护室病人家属的需求:一个接地气的理论研究
J. Beer, P. Brysiewicz
Background . The unexpected admission of a loved one to an intensive care unit (ICU) may have a negative effect on the everyday lives of family members, as they have had little time to adjust. Hence, it is imperative for healthcare professionals to promote optimal outcomes for both the patient and family members during admission for critical illness. Objective . To explore and describe the needs of families during critical illness and to develop methods to provide family care during a critical illness of a loved one. Methods . The Strauss and Corbin grounded theory approach was used. In-depth interviews with 16 intensive care nurses, 6 doctors and 9 family members in private and public settings were completed. Results . Five codes emerged using the characteristic coding in grounded theory. These were identified as information sharing; reassurance; striving for consolation; garnering of resources; and cultural and religious co-operation. Conclusion . This study elicited the needs of family members of ICU patients. Methods tailored around these needs were presented to support family members during a critical illness.
背景。亲人意外入住重症监护病房(ICU)可能会对家庭成员的日常生活产生负面影响,因为他们几乎没有时间去适应。因此,医疗保健专业人员在危重疾病入院期间促进患者和家属的最佳结果是势在必行的。目标。探索和描述家庭在严重疾病期间的需求,并制定方法,在亲人的严重疾病期间提供家庭护理。方法。采用了Strauss和Corbin扎根理论方法。对私立和公立机构的16名重症监护护士、6名医生和9名家庭成员进行了深入访谈。结果。利用扎根理论中的特征编码,产生了五种编码。这些被认为是信息共享;保证;寻求安慰;获取资源;文化和宗教合作。结论。本研究引出了ICU患者家属的需求。方法量身定制的这些需求提出了支持家庭成员在危重疾病。
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引用次数: 21
Care or burn in the ICU 重症监护室的护理或烧伤
L. Michell
Burnout syndrome (BOS) is a common problem, affecting 25 60% of healthcare professionals (HCPs) working in the intensive care unit (ICU).[1] Recently an American Critical Care Societies’ collaborative statement called for action to improve the ICU working environment.[2] The core symptoms of BOS are emotional exhaustion, depersonalisations and perceived lack of personal accomplishment.[2] In a previous issue of this journal we published an editorial, ‘Crash and burn’, highlighting the problem of BOS and the closely associated condition of post-traumatic stress disorder in ICU personnel.[3] Several studies have identified stressful interactions with relatives as a factor that adds to the burden of this demanding workplace. The response of burnt-out doctors and nurses is to avoid or minimise contact with the relatives, particularly if they are perceived to be demanding or ‘difficult’. Understanding the needs of families can help us support families and, in doing so, help ourselves. Even when we are managing the most hopeless ICU patient, job satisfaction can be achieved by knowing that we have done the best we could to help a family cope with a stressful situation. In this issue we publish a study which used a grounded theory approach to establish the needs of the families of ICU patients.[4] Common themes that emerged were the need for information sharing, reassurance, consolidation, resources, and cultural and religious awareness. Helping families that have been thrust into an unfamiliar and frightening situation to survive emotionally requires an understanding of the coping mechanisms relatives adopt. Establishing trust between HCPs and relatives is the first essential step. This is not achieved if discordant information is being supplied. De Beer and Brysiewicz’s study[4] highlights the problem of contradictory information being supplied by different members of the ICU team. An earlier study[5] conducted in French ICUs also showed that consistent information was the most important factor associated with family satisfaction. Communication is a two-way street and involves not only informing the relatives of the patient’s condition in an appropriate and compassionate way but also listening to family members and allowing them time to voice their fears and concerns. Family conferences where relatives talk more than the doctor are rated as more satisfactory by the family.[6] The need for reassurance was another key theme that emergend from the study. This is not such a simple need to meet in the critically ill. It is our human instinct to reassure, and families are keen to grasp at any straw offered. Unfortunately, we have all seen apparently improving patients suddenly deteriorate, and the ensuing blame games that may follow. The opposite extreme, of being overly pessimistic, is also not appropriate as we should not deny the ‘right to hope’ as long as there is some justification for this. Perhaps the best approach is one of cautious optimism, while
职业倦怠综合征(BOS)是一种常见的问题,影响了在重症监护病房(ICU)工作的医疗保健专业人员(HCPs)的25.60%最近,一份美国重症监护协会的合作声明呼吁采取行动改善ICU的工作环境BOS的核心症状是情绪耗竭、人格解体和感觉上缺乏个人成就感在本刊的前一期中,我们发表了一篇社论,“崩溃和烧伤”,强调了重症监护室人员的创伤后应激障碍问题和与之密切相关的创伤后应激障碍状况几项研究已经确定,与亲戚的紧张互动是增加这种高要求工作场所负担的一个因素。疲惫不堪的医生和护士的反应是避免或尽量减少与亲属的接触,特别是如果他们被认为要求很高或“难以相处”。了解家庭的需要可以帮助我们支持家庭,同时也帮助我们自己。即使当我们在管理最绝望的ICU病人时,知道我们已经尽了最大的努力来帮助一个家庭应对压力,我们也能获得工作满意度。在这一期,我们发表了一项研究,该研究采用扎根理论的方法来确定ICU患者家属的需求出现的共同主题是对信息共享、保证、巩固、资源以及文化和宗教意识的需求。帮助那些被推入陌生和可怕环境的家庭在情感上生存下来,需要了解亲属采用的应对机制。在医护人员和家属之间建立信任是必不可少的第一步。如果提供的信息不一致,这是无法实现的。De Beer和Brysiewicz的研究b[4]强调了ICU团队不同成员提供的相互矛盾的信息的问题。在法国icu进行的一项早期研究也表明,一致的信息是与家庭满意度相关的最重要因素。沟通是双向的,不仅要以适当和富有同情心的方式告知亲属患者的病情,还要倾听家属的意见,让他们有时间表达他们的恐惧和担忧。在家庭会议上,亲戚比医生说得多,家人认为更令人满意对安慰的需求是研究中出现的另一个关键主题。这不是危重病人需要满足的简单需求。让人放心是我们人类的本能,而家庭热衷于抓住任何一根救命稻草。不幸的是,我们都见过明显好转的病人突然恶化,随之而来的是指责游戏。相反的极端,过度悲观,也是不合适的,因为我们不应该否认“希望的权利”,只要有一些理由。也许最好的办法是保持谨慎的乐观,同时向家属保证,一切可能的事情都在为他们所爱的人做。为那些长时间呆在ICU的家庭提供合适的设施往往被忽视,特别是在我们资金紧张的州立医院。最低要求是舒适的床边座位,一个设备齐全的等候区和一个单独的私人房间用于家庭会议。一本关于ICU和过夜设施的说明性小册子是当前研究的另一个建议我们为病人尽了最大的努力,但在忙碌的临床生活中,我们常常忽略了家庭的需求。照顾他们的家人是病人想要的,在这样做的同时,我们也在照顾自己。
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引用次数: 0
Barriers to implementing evidence-based practice in a private intensive care unit in the Eastern Cape 东开普省私营重症监护病房实施循证实践的障碍
P. Jordan, C. Bowers, D. Morton
Background . Evidence-based practices (EBPs) have been promoted to enhance the delivery of patient care, reduce cost, increase patient and family satisfaction and contribute to professional development. Individual and organisational barriers can hamper the implementation of EBP, which can be detrimental to healthcare delivery. Objective . To determine the individual and organisational implementation barriers of EBP among nurses in a private intensive care unit (ICU). Methods . A quantitative research design was used to collect data from nurses in a private ICU in the Eastern Cape Province, South Africa. The structured questionnaire (Cronbach’s alpha: 0.72) was administered to 70 respondents, with a response rate of 93%. Results . Barriers at individual level were identified, and include lack of familiarity with EBP, individual perceptions that underpin clinical decision-making, lack of access to information required for EBP, inadequate sources to access evidence, inability to synthesise the literature available, and resistance to change. Barriers related to organisational support, change and operations were identified. Conclusion . Although the findings were similar to other studies, this study showed that nurses younger than 40 years of age were more familiar with the concepts of EBP. Physicians were perceived as not being very supportive of EBP implementation. In order to enhance healthcare delivery in the ICUs, nurse managers need to take cognisance of the individual and organisational barriers that might hamper the implementation of EBP.
背景。循证实践(ebp)已被推广,以加强提供病人护理,降低成本,提高病人和家属的满意度,并有助于专业发展。个人和组织的障碍可能阻碍EBP的实施,这可能不利于医疗保健服务的提供。目标。目的:确定私立重症监护病房(ICU)护士个人和组织实施EBP的障碍。方法。定量研究设计用于收集来自南非东开普省一家私立ICU护士的数据。采用结构化问卷(Cronbach’s alpha: 0.72)对70名被调查者进行问卷调查,回复率为93%。结果。确定了个体层面的障碍,包括对EBP缺乏熟悉,支持临床决策的个人认知,缺乏获取EBP所需信息的途径,获取证据的来源不足,无法综合现有文献,以及对变革的抵制。确定了与组织支持、变革和运营相关的障碍。结论。虽然研究结果与其他研究相似,但本研究显示年龄小于40岁的护士对EBP的概念更为熟悉。医生被认为不太支持EBP的实施。为了加强icu的医疗服务,护士管理者需要认识到可能阻碍EBP实施的个人和组织障碍。
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引用次数: 33
The capabilities and scope-of-practice requirements of advanced life support practitioners undertaking critical care transfers: A Delphi study 进行重症监护转移的高级生命支持从业人员的能力和实践范围要求:德尔菲研究
M. Venter, W. Stassen
Background . Critical care transfers (CCT) refer to the high level of care given during transport (via ambulance, helicopter or fixed-wing aircraft) of patients who are of high acuity. In South Africa (SA), advanced life support (ALS) paramedics undertake CCTs. The scope of ALS in SA has no extended protocol regarding procedures or medications in terms of dealing with these CCTs. Aim . The aim of this study was to obtain the opinions of several experts in fields pertaining to critical care and transport and to gain consensus on the skills and scope-of-practice requirements of paramedics undertaking CCTs in the SA setting. Methods . A modified Delphi study consisting of three rounds was undertaken using an online survey platform. A heterogeneous sample ( n =7), consisting of specialists in the fields of anaesthesiology, emergency medicine, internal medicine, critical care, critical care transport and paediatrics, was asked to indicate whether, in their opinion, selected procedures and medications were needed within the scope of practice of paramedics undertaking CCTs. Results . After three rounds, consensus was obtained in 70% (57/81) of procedures and medications. Many of these items are not currently within the scope of paramedics’ training. The panel felt that paramedics undertaking these transfers should have additional postgraduate training that is specific to critical care. Conclusion . Major discrepancies exist between the current scope of paramedic practice and the suggested required scope of practice for CCTs. An extended scope of practice and additional training should be considered for these practitioners.
背景。重症监护转移(CCT)是指在运送(通过救护车、直升机或固定翼飞机)高敏度患者期间给予的高水平护理。在南非(SA),高级生命支持(ALS)护理人员进行有条件现金转移治疗。ALS在SA的范围内没有关于处理这些cct的程序或药物的扩展协议。的目标。本研究的目的是获得与重症监护和运输相关领域的几位专家的意见,并就在SA环境中进行有条件现金转移治疗的护理人员的技能和执业范围要求达成共识。方法。采用在线调查平台进行了三轮改进的德尔菲研究。由麻醉学、急诊医学、内科、重症监护、重症监护运输和儿科等领域的专家组成的异质性样本(n =7)被要求表明,在他们看来,在进行有条件现金转移治疗的护理人员的实践范围内,是否需要选定的程序和药物。结果。三轮后,70%(57/81)的手术和药物获得了共识。其中许多项目目前不在护理人员培训的范围内。专家小组认为,承担这些转诊工作的护理人员应接受额外的针对重症监护的研究生培训。结论。目前护理人员的执业范围与建议的cct执业范围之间存在重大差异。应考虑扩大这些从业人员的实践范围和额外的培训。
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引用次数: 6
Reducing paediatric ventilator-associated pneumonia – a South African challenge! 减少儿童呼吸机相关肺炎——南非面临的挑战!
H. Kunzmann, K. Dimitriades, B. Morrow, A. Argent
There has been a decline in ventilator-associated pneumonia (VAP) in the paediatric intensive care units of developed countries. Previous studies at the Red Cross War Memorial Children’s Hospital give an incidence of VAP of >40/1 000 ventilator days, identifying VAP as a priority area for practice improvement. We outline the process and outcome of a practice improvement initiative that implemented an evidence-based bundle of care to reduce VAP. In 2011, this initiative was taken to improve healthcare-associated infections, with the support of the ‘Best Care Always’ project. A task team identified an evidence-based bundle of care aimed at reducing VAP. The bundle consisted of five elements that were adjusted practically to suit the unit. Standardised metrics to measure compliance with the bundle and outcomes of the intervention were instituted and collected prospectively throughout the study period. Following implementation in October 2011, VAP rates decreased from 55/1 000 to 19.1/1 000 ventilator days over the first 5-month period. During this period, compliance remained poor and metrics were poorly collected. With the introduction of a full-time VAP coordinator, compliance improved from 57% to a peak of 83%, with a decrease in VAP to an average of 4/1 000 ventilator days (January 2013 - July 2013). This practice improvement initiative resulted in a significant reduction in VAP. The success of this initiative is attributed equally to the introduction of the bundle of care and driving power of the VAP coordinator.
在发达国家的儿科重症监护病房中,呼吸机相关肺炎(VAP)的发病率有所下降。红十字战争纪念儿童医院先前的研究表明,VAP的发生率>40/ 1000呼吸机日,确定VAP是实践改进的优先领域。我们概述了实践改进倡议的过程和结果,该倡议实施了以证据为基础的一揽子护理,以减少VAP。2011年,在"始终提供最佳护理"项目的支持下,采取了这一举措,以改善与医疗保健有关的感染。一个任务小组确定了一个以证据为基础的一揽子护理,旨在降低VAP。该束由五个元素组成,实际调整以适应单位。在整个研究期间,制定并前瞻性地收集了衡量一揽子干预措施依从性和干预结果的标准化指标。自2011年10月实施以来,在前5个月期间,VAP率从55/ 1000降至19.1/ 1000呼吸机日。在此期间,遵从性仍然很差,度量标准收集得很差。随着全职VAP协调员的引入,依从性从57%提高到83%的峰值,VAP降低到平均4/ 1000呼吸机日(2013年1月至2013年7月)。这一实践改进举措显著降低了VAP。这一举措的成功同样归因于引入了综合护理和VAP协调员的推动力量。
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引用次数: 5
Physiotherapy practice in South African intensive care units 南非重症监护病房的物理治疗实践
H. van Aswegen, M. Lottering
Background. Physiotherapists are integral members of the interprofessional team that provides care and rehabilitation for patients in intensive care units (ICUs). Objectives. To describe the current practice of physiotherapists in ICUs, determine if physiotherapists’ practice has changed since a previous report and determine if practice is evidence based. Methodology. A questionnaire was content validated and made available electronically and in hard copy. Physiotherapists who work in ICUs in public or private sector hospitals or who are members of the South African Society of Physiotherapy were identified and invited to participate. Results. Survey response rate was 33.9%. Patient assessment techniques performed ‘very often’ included ICU chart assessment ( n =90, 83.3%), chest auscultation ( n =94, 81.8%) and cough effort ( n =81, 75%). Treatment techniques performed ‘very often’ included manual chest clearance ( n =101, 93.5%), in-bed mobilisation and positioning ( n =91, 84.3%; n =91, 84.3%, respectively), airway suctioning ( n =89, 82.4%), out-of-bed mobilisation ( n =84, 77.8%), deep breathing exercises (n=83, 76.9%) and peripheral muscle-strengthening exercises ( n =72, 73.1%). More respondents used intermittent positive pressure breathing (57 v. 28%, p =0.00), used adjustment of mechanical ventilation (MV) settings (30 v. 15%, p =0.01), were involved with weaning patients from MV (42 v. 19%, p =0.00) and used incentive spirometry (76 v. 46%, p =0.00) than reported previously. More respondents performed suctioning (99 v. 70%, p =0.00), extubation (60 v. 25%, p =0.00) and adjustment of MV settings (30 v. 12%, p =0.02) than reported internationally. Conclusion. Physiotherapy practice in ICUs is evidence based. Care focuses largely on mobilisation, exercise therapy and multimodality respiratory therapy.
背景。物理治疗师是为重症监护病房(icu)患者提供护理和康复的跨专业团队的重要成员。目标。为了描述icu中物理治疗师的当前实践,确定物理治疗师的实践自之前的报告以来是否发生了变化,并确定实践是否基于证据。方法。对调查表进行了内容验证,并以电子和硬拷贝形式提供。确定并邀请在公立或私营医院重症监护室工作的物理治疗师或南非物理治疗学会成员参加。结果。调查回应率为33.9%。“非常经常”进行的患者评估技术包括ICU图表评估(n =90, 83.3%)、胸部听诊(n =94, 81.8%)和咳嗽力度(n =81, 75%)。“非常常见”的治疗技术包括手动清胸(n =101, 93.5%),床上活动和定位(n =91, 84.3%;N =91, 84.3%)、气道吸引(N =89, 82.4%)、床下活动(N =84, 77.8%)、深呼吸练习(N =83, 76.9%)和外周肌肉强化练习(N =72, 73.1%)。与之前的报道相比,更多的受访者使用间歇性正压呼吸(57 vs 28%, p =0.00),使用机械通气(MV)设置调整(30 vs 15%, p =0.01),参与脱离MV的患者(42 vs 19%, p =0.00)和使用激励肺量计(76 vs 46%, p =0.00)。与国际报道相比,更多的受访者进行了吸痰(99 vs 70%, p =0.00),拔管(60 vs 25%, p =0.00)和MV设置调整(30 vs 12%, p =0.02)。结论。icu的物理治疗实践是基于证据的。护理主要侧重于活动,运动治疗和多模式呼吸治疗。
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引用次数: 11
Post-tracheostomy tracheo-oesophageal fistula - an unusual presentation 气管切开术后气管-食管瘘-一种不寻常的表现
C. Deepa, S. Kamat, V. Ravindran
Tracheostomy, one of the oldest known surgical procedures in the history of medicine, is regularly performed in modern intensive care units. Acquired ulcerative tracheo-oesophageal fistula (TOF) is an uncommon but potentially fatal complication of tracheostomy. We report a case of ulcerative TOF with an unusual yet characteristic presentation, in a ventilator-dependent tracheostomised patient with Guillain-Barre syndrome. It presented as sudden progressive severe abdominal distension that was rhythmic with each ventilator breath. The predisposing factors, clinical features and preventive measures of post-tracheostomy TOF are discussed in this case report. Regular monitoring of tracheal tube cuff pressures and volumes, along with avoidance and treatment of various predisposing factors, are advisable for the prevention of this serious consequence.
气管切开术是医学史上最古老的外科手术之一,在现代重症监护病房经常进行。摘要获得性溃疡性气管食管瘘是气管切开术中一种罕见但可能致命的并发症。我们报告一例溃疡性TOF与一个不寻常但特征性的表现,在呼吸机依赖气管造口患者与格林-巴利综合征。表现为突发性进行性严重腹胀,每次呼吸都有节律性。本文就气管切开术后TOF的易感因素、临床特点及预防措施进行讨论。定期监测气管套管的压力和体积,同时避免和治疗各种诱发因素,可以预防这种严重后果。
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引用次数: 1
Physiotherapy contributions to weaning and extubation of patients from mechanical ventilation 物理治疗有助于患者从机械通气中脱机和拔管
D. Morar, H. V. Aswegen
Background. Liberation of patients from mechanical ventilation (MV) is an important goal of patient care, to avoid the complications and risks associated with prolonged MV. Objective. To determine the extent of South African physiotherapists’ involvement in weaning and extubation of patients from MV and whether current practice is evidence based. Method. A survey questionnaire was developed, and content validated and made available electronically and in hard copy. Physiotherapists working in adult intensive care units in public and private sector hospitals in South Africa (SA) were identified and invited to participate. Results. Response rate was 43% (n=184). The majority of respondents (n=135, 73%) ‘never’ or ‘seldom’ got involved in decision-making to wean patients from MV; a minority (n=8, 4%) were ‘routinely’ involved in decision-making. Some respondents (n=54, 29%) performed extubation ‘often’ or ‘routinely’. The majority used exercises (n=149, 81%), early mobilisation out of bed (n=142, 77%) and deep breathing exercises (DBEs) (n=142, 77%) ‘routinely’ to aid in respiratory muscle training. The majority of respondents ‘never’ adjusted ventilator settings other than fraction of inspired oxygen. No association was found between type of physiotherapy degree respondents held and their involvement in weaning (p=0.24). Conclusion. SA physiotherapists’ contributions towards weaning of patients from MV through prescription of exercise therapy, early outof- bed mobilisation and DBEs is evidence based. Involvement in adjustment of MV settings, decision-making regarding patient weaning, development of weaning protocols for their units and extubation is limited.
背景。将患者从机械通气(MV)中解放出来是患者护理的一个重要目标,以避免长期机械通气相关的并发症和风险。目标。确定南非物理治疗师参与MV患者脱机和拔管的程度,以及目前的实践是否基于证据。方法。编制了一份调查问卷,对内容进行了验证,并以电子和硬拷贝的形式提供。在南非公立和私营医院的成人重症监护病房工作的物理治疗师被确定并邀请参加。结果。有效率为43% (n=184)。大多数受访者(n=135, 73%)“从未”或“很少”参与患者戒断MV的决策;少数人(n= 8.4%)“常规地”参与决策。一些应答者(n= 54,29 %)“经常”或“常规”拔管。大多数患者“常规”使用锻炼(n=149, 81%)、早期下床活动(n=142, 77%)和深呼吸练习(n=142, 77%)来辅助呼吸肌训练。大多数受访者“从未”调整呼吸机设置,而不是吸入氧气的一部分。被调查者所接受的物理治疗程度类型与他们是否参与断奶没有关联(p=0.24)。结论。SA物理治疗师通过处方运动疗法,早期下床活动和DBEs对患者从MV中断奶的贡献是基于证据的。参与MV设置的调整,关于患者脱机的决策,制定脱机方案的单位和拔管是有限的。
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引用次数: 4
An observational study on the relationship between plasma vitamin C, blood glucose, oxidative stress, endothelial dysfunction and outcome in patients with septic shock 感染性休克患者血浆维生素C、血糖、氧化应激、内皮功能障碍与预后关系的观察研究
Kondwani G H Katundu, L. Hill, Lester M. Davids, Ivan A Joubert, Malcolm G A Miller, J. L. Piercy, William L Michelle
Background. Septic shock is associated with endothelial dysfunction and oxidative stress, against which vitamin C plays a protective role, possibly influencing clinical outcome. Hyperglycaemia may lower vitamin C. Objective. To study plasma vitamin C, oxidative stress, hyperglycaemia, endothelial dysfunction and outcome in septic shock. Methods. In a prospective, observational study of 25 adult septic shock patients, serial blood samples were analysed for vitamin C, thiobarbituric acid-reactive substances (TBARS) (a biomarker of oxidative stress), and soluble vascular cell adhesion molecule-1 (sVCAM-1) and E-selectin (markers of endothelial dysfunction). Blood glucose, Sequential Organ Failure Assessment (SOFA) scores and fluid requirements were monitored. Results. Plasma vitamin C was low, while plasma TBARS were high throughout the 7-day study period. Endothelial dysfunction markers (sVCAM-1 and E-selectin) were high at the baseline. VCAM-1 decreased significantly on day 1 and normalised on day 7. E-selectin was unchanged on day 1 compared with baseline, but increased significantly on day 7. Oxidative stress and endothelial dysfunction were associated with increased SOFA score. Increased oxidative stress was associated with increased requirements for intravenous fluids and prolonged duration of vasoconstrictor support. Nine patients died in hospital. At baseline, levels of TBARS were significantly higher in non-survivors than in the survivors of septic shock. Conclusion. In septic shock, clinically relevant oxidative stress was associated with endothelial dysfunction, low vitamin C and high glucoseto- vitamin-C ratios. Markers of oxidative stress and endothelial damage were increased and correlated with resuscitation fluid requirements, vasoconstrictor use, organ failure and mortality.
背景。感染性休克与内皮功能障碍和氧化应激有关,维生素C对其起保护作用,可能影响临床结果。高血糖会降低维生素c。探讨感染性休克患者血浆维生素C、氧化应激、高血糖、内皮功能障碍与预后的关系。方法。在一项前瞻性观察性研究中,研究人员对25名成人感染性休克患者的血液样本进行了维生素C、硫代巴比妥酸反应物质(TBARS)(氧化应激的生物标志物)、可溶性血管细胞粘附分子-1 (sVCAM-1)和e-选择素(内皮功能障碍的标志物)的分析。监测血糖、顺序器官衰竭评估(SOFA)评分和液体需要量。结果。在整个7天的研究期间,血浆维生素C较低,而血浆TBARS较高。内皮功能障碍标志物(sVCAM-1和e -选择素)在基线时较高。VCAM-1在第1天显著下降,第7天恢复正常。与基线相比,e -选择素在第1天没有变化,但在第7天显著增加。氧化应激和内皮功能障碍与SOFA评分升高有关。氧化应激增加与静脉输液需求增加和血管收缩剂支持持续时间延长有关。9名病人在医院死亡。在基线时,非幸存者的TBARS水平明显高于脓毒性休克幸存者。结论。在感染性休克中,临床相关的氧化应激与内皮功能障碍、低维生素C和高葡萄糖-维生素C比值有关。氧化应激和内皮损伤标志物增加,并与复苏液体需要量、血管收缩剂使用、器官衰竭和死亡率相关。
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引用次数: 5
Incidence and risk factors for thrombocytopenia in the intensive care units of a tertiary hospital in northern India 印度北部一家三级医院重症监护病房中血小板减少症的发病率和危险因素
Chitra Mehta, Joby V. George, Y. Mehta, M. T. Ali, M. Singh
Background. In Western countries, incidence of thrombocytopenia in intensive care units (ICUs) has been found to be 13 - 44%. We chose to study the incidence, risk factors and transfusion requirements of thrombocytopenia in tertiary care ICUs in northern India. Objective. To study the incidence and risk factors of thrombocytopenia in a mixed ICU. Methods. This prospective observational 6-month cohort study was conducted in two 22-bedded medical-surgical ICUs. Patients aged 18 years or older with an ICU stay of at least 2 days were included. Results. Thrombocytopenia (<150 000/dL) occurred in 190 (38%) of the 500 patients studied. Thrombocytopenia was present on admission in 41 (8%) patients. Of the remaining patients, 149 (32%) developed new-onset thrombocytopenia (NOT) – thrombocytopenia developing in patients with platelet count more than 150 000/U on admission – during ICU stay. Incidence and prevalence were 30% and 38%, respectively. ICU mortality was 13%. Thrombocytopenia was commonly associated with sepsis, disseminated intravascular coagulation, heparin and certain antibiotics. Cause could not be established in 10 patients. Underlying coronary artery disease and sepsis correlated with thrombocytopenia. Mortality was higher in patients with NOT (15.4 v. 8.7%, p=0.003). Compared with non-thrombocytopenic patients, patients with NOT required more blood product transfusions (57.7 v. 38.4%, p=0.000) and mechanical ventilation (23.5 v. 13.5%, p=0.008). No difference was observed in length of hospital stay and bleeding risk between the two groups. Conclusion. We found incidence and prevalence of thrombocytopenia in the ICU comparable with internationally reported figures. NOT was associated with higher mortality and morbidity and may be considered as a marker of disease severity.
背景。在西方国家,重症监护病房(icu)的血小板减少症发病率为13 - 44%。我们选择研究印度北部三级icu中血小板减少症的发生率、危险因素和输血需求。目标。目的:探讨混合ICU患者血小板减少的发生率及危险因素。方法。这项为期6个月的前瞻性观察队列研究是在两个22个床位的内科-外科icu中进行的。患者年龄≥18岁,ICU住院时间≥2天。结果。500例患者中有190例(38%)发生血小板减少症(< 150000 /dL)。41例(8%)患者入院时出现血小板减少。在其余患者中,149例(32%)出现新发血小板减少症(NOT)——入院时血小板计数超过15万/U的患者在ICU住院期间出现血小板减少症。发病率和患病率分别为30%和38%。ICU死亡率为13%。血小板减少症通常与败血症、弥散性血管内凝血、肝素和某些抗生素有关。10例患者病因不明。潜在的冠状动脉疾病和败血症与血小板减少症相关。NOT患者的死亡率更高(15.4% vs 8.7%, p=0.003)。与非血小板减少患者相比,非血小板减少患者需要更多的血液制品输注(57.7 vs 38.4%, p=0.000)和机械通气(23.5 vs 13.5%, p=0.008)。两组患者住院时间和出血风险无差异。结论。我们发现ICU中血小板减少症的发生率和患病率与国际上报道的数据相当。NOT与较高的死亡率和发病率相关,可视为疾病严重程度的标志。
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引用次数: 4
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The Southern African journal of critical care : the official journal of the Critical Care Society
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