Pub Date : 1984-03-01DOI: 10.1097/00006454-198403000-00033
M. Szaff, N. Høiby, E. W. Flensborg
During the period 1971-75, 51 cystic fibrosis (CF) patients who contracted chronic P. aeruginosa infection were treated at the Danish CF centre with anti-pseudomonas chemotherapy only when their clinical condition deteriorated considerably. During the period 1976-80, 58 CF patients who contracted chronic P. aeruginosa infection were treated at the Danish CF centre with anti-pseudomonas chemotherapy on a regular basis every 3 months. Each routine 24 day-course of chemotherapy consisted of tobramycin in combination with carbenicillin or other beta-lactam antibiotics with activity against P. aeruginosa. In case of allergy or resistant strains monotherapy with tobramycin was used. The 5-year survival of CF patients from the time of the onset of the chronic P. aeruginosa infection increased from 54% in the first period to 82% in the second period (p less than 0.05), and lung function (peak expiratory flow rate) also improved significantly. It is concluded that intensive "maintenance" chemotherapy against P. aeruginosa improves survival and quality of life of CF patients although permanent eradication of P. aeruginosa is not accomplished.
{"title":"Frequent antibiotic therapy improves survival of cystic fibrosis patients with chronic Pseudomonas aeruginosa infection.","authors":"M. Szaff, N. Høiby, E. W. Flensborg","doi":"10.1097/00006454-198403000-00033","DOIUrl":"https://doi.org/10.1097/00006454-198403000-00033","url":null,"abstract":"During the period 1971-75, 51 cystic fibrosis (CF) patients who contracted chronic P. aeruginosa infection were treated at the Danish CF centre with anti-pseudomonas chemotherapy only when their clinical condition deteriorated considerably. During the period 1976-80, 58 CF patients who contracted chronic P. aeruginosa infection were treated at the Danish CF centre with anti-pseudomonas chemotherapy on a regular basis every 3 months. Each routine 24 day-course of chemotherapy consisted of tobramycin in combination with carbenicillin or other beta-lactam antibiotics with activity against P. aeruginosa. In case of allergy or resistant strains monotherapy with tobramycin was used. The 5-year survival of CF patients from the time of the onset of the chronic P. aeruginosa infection increased from 54% in the first period to 82% in the second period (p less than 0.05), and lung function (peak expiratory flow rate) also improved significantly. It is concluded that intensive \"maintenance\" chemotherapy against P. aeruginosa improves survival and quality of life of CF patients although permanent eradication of P. aeruginosa is not accomplished.","PeriodicalId":75407,"journal":{"name":"Acta paediatrica Scandinavica","volume":"72 5 1","pages":"651-7"},"PeriodicalIF":0.0,"publicationDate":"1984-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1097/00006454-198403000-00033","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"61798641","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 1984-03-01DOI: 10.1097/00006454-198403000-00032
C. Speer, A. Bruns, M. Gahr
In 312 preterm and term newborn infants serum concentrations of C-reactive protein (CRP), haptoglobin and alpha 1-antitrypsin were measured during several days by radial immunodiffusion. In addition white blood cell count and the ratio of band to total neutrophils (B/N-ratio) were determined. In 12 infants with proven sepsis CRP was found elevated above the upper limit of the normal range (20 mg/l). Successful therapy was followed by a decrease of CRP concentration. In infants with suspected infection high CRP values were found in most cases. In contrast, haptoglobin and alpha 1-antitrypsin concentrations differed not significantly between the group of infants without infection, with proven and with suspected infection. White blood cell count and B/N-ratio also were not appropriate for the early identification of bacterial infection in the newborn period.
{"title":"Sequential determination of CRP, alpha 1-antitrypsin and haptoglobin in neonatal septicaemia.","authors":"C. Speer, A. Bruns, M. Gahr","doi":"10.1097/00006454-198403000-00032","DOIUrl":"https://doi.org/10.1097/00006454-198403000-00032","url":null,"abstract":"In 312 preterm and term newborn infants serum concentrations of C-reactive protein (CRP), haptoglobin and alpha 1-antitrypsin were measured during several days by radial immunodiffusion. In addition white blood cell count and the ratio of band to total neutrophils (B/N-ratio) were determined. In 12 infants with proven sepsis CRP was found elevated above the upper limit of the normal range (20 mg/l). Successful therapy was followed by a decrease of CRP concentration. In infants with suspected infection high CRP values were found in most cases. In contrast, haptoglobin and alpha 1-antitrypsin concentrations differed not significantly between the group of infants without infection, with proven and with suspected infection. White blood cell count and B/N-ratio also were not appropriate for the early identification of bacterial infection in the newborn period.","PeriodicalId":75407,"journal":{"name":"Acta paediatrica Scandinavica","volume":"72 5 1","pages":"679-83"},"PeriodicalIF":0.0,"publicationDate":"1984-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1097/00006454-198403000-00032","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"61798632","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 1984-01-01DOI: 10.1097/00006454-198501000-00036
S. Seeberg, B. Brinkhoff, E. John, I. Kjellmer
The extent of staphylococcal colonisation and neonatal pyoderma was studied in 5 220 infants in two large Swedish hospitals in 1979-1982. A method for routine cord care with 4% chlorhexidine detergent solution was evaluated in one hospital. Nursery colonisation with Staph. aureus and streptococci decreased significantly. The method proved to be clinically efficient for prevention of pyoderma in the nursery as well as for controlling staphylococcal infection after discharge from hospital. The combined use of a quantitative sampling method and phage-typing showed that most post-discharge lesions were nursery-derived. In one of the hospitals, daily cord care with 70% ethanol failed to prevent streptococcal and staphylococcal omphalitis in the nursery whereas daily cord care with chlorhexidine reduced the incidence of omphalitis from 21 to 1%.
{"title":"Prevention and control of neonatal pyoderma with chlorhexidine.","authors":"S. Seeberg, B. Brinkhoff, E. John, I. Kjellmer","doi":"10.1097/00006454-198501000-00036","DOIUrl":"https://doi.org/10.1097/00006454-198501000-00036","url":null,"abstract":"The extent of staphylococcal colonisation and neonatal pyoderma was studied in 5 220 infants in two large Swedish hospitals in 1979-1982. A method for routine cord care with 4% chlorhexidine detergent solution was evaluated in one hospital. Nursery colonisation with Staph. aureus and streptococci decreased significantly. The method proved to be clinically efficient for prevention of pyoderma in the nursery as well as for controlling staphylococcal infection after discharge from hospital. The combined use of a quantitative sampling method and phage-typing showed that most post-discharge lesions were nursery-derived. In one of the hospitals, daily cord care with 70% ethanol failed to prevent streptococcal and staphylococcal omphalitis in the nursery whereas daily cord care with chlorhexidine reduced the incidence of omphalitis from 21 to 1%.","PeriodicalId":75407,"journal":{"name":"Acta paediatrica Scandinavica","volume":"73 4 1","pages":"498-504"},"PeriodicalIF":0.0,"publicationDate":"1984-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1097/00006454-198501000-00036","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"61799348","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 1983-09-01DOI: 10.1111/j.1651-2227.1983.tb09803.x
B Strömberg, P A Oberg, G Sedin
In order to investigate whether sweating and cutaneous vasodilatation. induced by a warm environment, is inhibited by central cold-stimulation, the evaporation rate and skin blood flow were studied by non-invasive techniques before and after the feeding of cold glucose to 17 fullterm appropriate for gestational age infants, born by elective Caesarean section, on their first day after birth. In newborn infants who were visibly sweating and had an increased skin blood flow at a body temperature above 37.1 degrees C, such central cold-stimulation quickly inhibited sweating and decreased skin blood flow. In infants with almost the same body temperature but with no sweating, this stimulation caused no change in evaporation rate or skin blood flow. The regulation of body temperature in fullterm newborn infants can thus be disturbed by central cold-stimulation, resulting in a decreased heat loss to the environment even though the body temperature is elevated.
{"title":"Transepidermal water loss in newborn infants. X. Effects of central cold-stimulation on evaporation rate and skin blood flow.","authors":"B Strömberg, P A Oberg, G Sedin","doi":"10.1111/j.1651-2227.1983.tb09803.x","DOIUrl":"https://doi.org/10.1111/j.1651-2227.1983.tb09803.x","url":null,"abstract":"<p><p>In order to investigate whether sweating and cutaneous vasodilatation. induced by a warm environment, is inhibited by central cold-stimulation, the evaporation rate and skin blood flow were studied by non-invasive techniques before and after the feeding of cold glucose to 17 fullterm appropriate for gestational age infants, born by elective Caesarean section, on their first day after birth. In newborn infants who were visibly sweating and had an increased skin blood flow at a body temperature above 37.1 degrees C, such central cold-stimulation quickly inhibited sweating and decreased skin blood flow. In infants with almost the same body temperature but with no sweating, this stimulation caused no change in evaporation rate or skin blood flow. The regulation of body temperature in fullterm newborn infants can thus be disturbed by central cold-stimulation, resulting in a decreased heat loss to the environment even though the body temperature is elevated.</p>","PeriodicalId":75407,"journal":{"name":"Acta paediatrica Scandinavica","volume":"72 5","pages":"735-9"},"PeriodicalIF":0.0,"publicationDate":"1983-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1111/j.1651-2227.1983.tb09803.x","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17691873","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 1983-09-01DOI: 10.1111/j.1651-2227.1983.tb09815.x
P S Pedersen, E Christensen, N J Brandt
The clinical and biochemical findings in a four-year-old girl with prolidase deficiency, treated with L-proline, manganese and ascorbic acid, are presented.
临床和生化结果在一个四岁的女孩与脯氨酸，锰和抗坏血酸治疗的脯氨酸酶缺乏症，提出。
{"title":"Prolidase deficiency.","authors":"P S Pedersen, E Christensen, N J Brandt","doi":"10.1111/j.1651-2227.1983.tb09815.x","DOIUrl":"https://doi.org/10.1111/j.1651-2227.1983.tb09815.x","url":null,"abstract":"<p><p>The clinical and biochemical findings in a four-year-old girl with prolidase deficiency, treated with L-proline, manganese and ascorbic acid, are presented.</p>","PeriodicalId":75407,"journal":{"name":"Acta paediatrica Scandinavica","volume":"72 5","pages":"785-8"},"PeriodicalIF":0.0,"publicationDate":"1983-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1111/j.1651-2227.1983.tb09815.x","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17693554","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 1983-09-01DOI: 10.1111/j.1651-2227.1983.tb09817.x
G Wennergren, J Bjure, I Kjellmer
A SIDS sibling is described who showed a normal respiratory regulation at 1.5 months but who was equipped with an apnea monitor at home on psychological indications. At 3 months he had a near-miss SIDS episode. He was then found to have developed a reaction to hypoxia with appearance of periodic breathing. With theophylline this response pattern was normalized but despite theophylline medication episodes of prolonged apnea occurred.
{"title":"A case of near-miss SIDS developing an abnormal respiratory reaction to hypoxia.","authors":"G Wennergren, J Bjure, I Kjellmer","doi":"10.1111/j.1651-2227.1983.tb09817.x","DOIUrl":"https://doi.org/10.1111/j.1651-2227.1983.tb09817.x","url":null,"abstract":"<p><p>A SIDS sibling is described who showed a normal respiratory regulation at 1.5 months but who was equipped with an apnea monitor at home on psychological indications. At 3 months he had a near-miss SIDS episode. He was then found to have developed a reaction to hypoxia with appearance of periodic breathing. With theophylline this response pattern was normalized but despite theophylline medication episodes of prolonged apnea occurred.</p>","PeriodicalId":75407,"journal":{"name":"Acta paediatrica Scandinavica","volume":"72 5","pages":"793-5"},"PeriodicalIF":0.0,"publicationDate":"1983-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1111/j.1651-2227.1983.tb09817.x","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17693556","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 1983-09-01DOI: 10.1111/j.1651-2227.1983.tb09813.x
O Eeg-Olofsson, U Lindskog
Multiple subcutaneous tumors were found at birth in a pair of identical twins, and the histological diagnosis was neurofibroma. The tumors disappeared within seven months. This disorder must be differentiated from congenital generalized fibromatosis, which usually shows a malignant course.
{"title":"Congenital neurofibromatosis. Multiple subcutaneous tumors with spontaneous regression in twins.","authors":"O Eeg-Olofsson, U Lindskog","doi":"10.1111/j.1651-2227.1983.tb09813.x","DOIUrl":"https://doi.org/10.1111/j.1651-2227.1983.tb09813.x","url":null,"abstract":"<p><p>Multiple subcutaneous tumors were found at birth in a pair of identical twins, and the histological diagnosis was neurofibroma. The tumors disappeared within seven months. This disorder must be differentiated from congenital generalized fibromatosis, which usually shows a malignant course.</p>","PeriodicalId":75407,"journal":{"name":"Acta paediatrica Scandinavica","volume":"72 5","pages":"779-80"},"PeriodicalIF":0.0,"publicationDate":"1983-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1111/j.1651-2227.1983.tb09813.x","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17474958","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 1983-09-01DOI: 10.1111/j.1651-2227.1983.tb09818.x
T Sakano, A Hosokawa, N Horino, S Hyodo, T Kishi, T Suzawa, E Kittaka, N Sakura, T Usui
We report a patient with low serum IgA levels and persistent pulmonary infection. In spite of the normal contents of serum IgG and IgM, the patient had a deficiency for plasma cell differentiation of all major classes of immunoglobulins (IgG, IgA and IgM). Cross culture systems between normal T or B cells and the patient's T or B cells showed a defect of both T and B cell function.
{"title":"A case of immunodeficiency with decreased serum IgA levels and impaired polyclonal B cell differentiation in vitro.","authors":"T Sakano, A Hosokawa, N Horino, S Hyodo, T Kishi, T Suzawa, E Kittaka, N Sakura, T Usui","doi":"10.1111/j.1651-2227.1983.tb09818.x","DOIUrl":"https://doi.org/10.1111/j.1651-2227.1983.tb09818.x","url":null,"abstract":"<p><p>We report a patient with low serum IgA levels and persistent pulmonary infection. In spite of the normal contents of serum IgG and IgM, the patient had a deficiency for plasma cell differentiation of all major classes of immunoglobulins (IgG, IgA and IgM). Cross culture systems between normal T or B cells and the patient's T or B cells showed a defect of both T and B cell function.</p>","PeriodicalId":75407,"journal":{"name":"Acta paediatrica Scandinavica","volume":"72 5","pages":"797-9"},"PeriodicalIF":0.0,"publicationDate":"1983-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1111/j.1651-2227.1983.tb09818.x","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17661547","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 1983-09-01DOI: 10.1111/j.1651-2227.1983.tb09806.x
G Mau, G Brinkmann, H Anger
Assmussen recently reported in several publications (1-5) on morphological alterations in the vessels of the umbilical cords and the placentae of neonates whose mothers had smoked cigarettes during pregnancy. They interpreted their findings as a prodromal form of arteriosclerotic changes in the vascular endothelium. The hyperlipoproteinemias are wellknown risk factors for arteriosclerotic cardiovascular diseases in adults as well as in childhood. It is established that there is a negative correlation between high density lipoprotein cholesterol concentration in the serum (HDL cholesterol) and arteriosclerosis. The low density lipoprotein and the very low density lipoprotein cholesterol (LDL and VLDL cholesterol) show a positive relationship with the vascular diseases. Studies on the influence of cigarette smoking on cholesterol metabolism show that the concentration of HDL cholesterol in the serum is lower than in nonsmokers (6, 7 ) . The lowering of HDL cholesterol can last up to one year after final abstinence ( 6 , 7 ) . Since the unborn child of a smoker is exposed to cigarette smoke for nine months, it appears possible that a shift of the LDL-HDL quotient might occur in the neonate. In the present study the umbilical cord blood from 78 neonates was investigated. Women under 18 and over 35 years of age, women with a severe varicosis, cardiovascular diseases, hypertension, metabolic diseases including disorders of lipid metabolism, with medication, drug, coffee and alcohol abuse as well as pregnant women with a cervical insufficiency or therapeutic cerclage and toxemia of pregnancy were excluded from the study. Further exclusion criteria were a pre-, intraor postnatal asphyxia of the child, pathological labor, abnormal presentation of the newborn, pathological Apgar score and shortened duration of pregnancy. The age, weight, height, number of earlier miscarriages, stillbirths and live births, duration of pregnancy and social status were comparable between controls and the smoker group. The interview with regard to smoking habits was carried out with a standardized questionnaire. A total of four groups were formed: Group 1 (n=23). Nonsmokers; control group with women who had smoked neither before (at least two years) nor during pregnan-
{"title":"Lipoprotein pattern in umbilical cord blood of neonates of smoking and non smoking mothers.","authors":"G Mau, G Brinkmann, H Anger","doi":"10.1111/j.1651-2227.1983.tb09806.x","DOIUrl":"https://doi.org/10.1111/j.1651-2227.1983.tb09806.x","url":null,"abstract":"Assmussen recently reported in several publications (1-5) on morphological alterations in the vessels of the umbilical cords and the placentae of neonates whose mothers had smoked cigarettes during pregnancy. They interpreted their findings as a prodromal form of arteriosclerotic changes in the vascular endothelium. The hyperlipoproteinemias are wellknown risk factors for arteriosclerotic cardiovascular diseases in adults as well as in childhood. It is established that there is a negative correlation between high density lipoprotein cholesterol concentration in the serum (HDL cholesterol) and arteriosclerosis. The low density lipoprotein and the very low density lipoprotein cholesterol (LDL and VLDL cholesterol) show a positive relationship with the vascular diseases. Studies on the influence of cigarette smoking on cholesterol metabolism show that the concentration of HDL cholesterol in the serum is lower than in nonsmokers (6, 7 ) . The lowering of HDL cholesterol can last up to one year after final abstinence ( 6 , 7 ) . Since the unborn child of a smoker is exposed to cigarette smoke for nine months, it appears possible that a shift of the LDL-HDL quotient might occur in the neonate. In the present study the umbilical cord blood from 78 neonates was investigated. Women under 18 and over 35 years of age, women with a severe varicosis, cardiovascular diseases, hypertension, metabolic diseases including disorders of lipid metabolism, with medication, drug, coffee and alcohol abuse as well as pregnant women with a cervical insufficiency or therapeutic cerclage and toxemia of pregnancy were excluded from the study. Further exclusion criteria were a pre-, intraor postnatal asphyxia of the child, pathological labor, abnormal presentation of the newborn, pathological Apgar score and shortened duration of pregnancy. The age, weight, height, number of earlier miscarriages, stillbirths and live births, duration of pregnancy and social status were comparable between controls and the smoker group. The interview with regard to smoking habits was carried out with a standardized questionnaire. A total of four groups were formed: Group 1 (n=23). Nonsmokers; control group with women who had smoked neither before (at least two years) nor during pregnan-","PeriodicalId":75407,"journal":{"name":"Acta paediatrica Scandinavica","volume":"72 5","pages":"755-6"},"PeriodicalIF":0.0,"publicationDate":"1983-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1111/j.1651-2227.1983.tb09806.x","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17636905","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 1983-09-01DOI: 10.1111/j.1651-2227.1983.tb09807.x
P S Pedersen, K W Kastrup
A The growth promoting effect of growth hormone is known to be mediated via somatomedins, a group of peptides produced mainly by the liver. A change in hepatic function or systemic forces which especially modify the formation of somatomedin by the liver, lower the somatomedin levels. The latter results in increased secretion of growth hormone presumably via feedback mechanisms ( I ) . The following studies were performed to evaluate somatomedin activity in patients suffering from cystic fibrosis (CF), knowing that in this disease growth failure, malnutrition and hepatic involvement are common features. Nineteen CF-patients with typical pulmonary and pancreatic symptoms were compared with 41 healthy children with normal development, height and weight. At the time studied the CF-patients were all clinically stable without signs of diabetes or hepatic involvement. The age distribution was equal for C F and normals (N: 155f26 months-CF: 156f29 months ( X f 2 SD)). All samples were obtained between 9 and 10 a.m. and promptly centrifuged and stored at -8OC until assayed. A modified analysis of sulphate incorporation in the pelvic cartilage of 12-day-old chick embryos was utilized (2). In spite of improved management of pulmonary and pancreatic complications in CF, retardation of skeletal growth is still a common manifestation of the disease (3), reported not to be confined to those with severe malabsorbtion or lung complications (4). The growth hormone levels have been reported normal or elevated (549, and other hormones influencing the growth and growth spurt have been reported normal including, thyroid hormones and gonadal and adrenal steroids (9-13). Recently two separate somatomedin studies have been reported (7, 14). By using bioassay in six patients with C F Lee et al. (14) demonstrated reduction of somatomedin activity to about 50% of values in normal children. The opposite result was obtained by Rosenfeld et al. (7), using placental membrane radioreceptor assay in measuring total somatomedin peptide content in plasma of 15 C F patients. The conflicting results have been discussed by the latter group. The presence of a circulating somatomedin inhibitor, whose existence might be secondary to either malnutrition or to an underlying metabolic defect in CF, is mentioned. Our results, showing normal somatomedin activity in C F patients (Fig. I ) , using a welldocumented bioassay (2), are however similar to the results presented by Rosenfeld et al. (7), suggesting normal generation of normally
{"title":"Somatomedin in cystic fibrosis.","authors":"P S Pedersen, K W Kastrup","doi":"10.1111/j.1651-2227.1983.tb09807.x","DOIUrl":"https://doi.org/10.1111/j.1651-2227.1983.tb09807.x","url":null,"abstract":"A The growth promoting effect of growth hormone is known to be mediated via somatomedins, a group of peptides produced mainly by the liver. A change in hepatic function or systemic forces which especially modify the formation of somatomedin by the liver, lower the somatomedin levels. The latter results in increased secretion of growth hormone presumably via feedback mechanisms ( I ) . The following studies were performed to evaluate somatomedin activity in patients suffering from cystic fibrosis (CF), knowing that in this disease growth failure, malnutrition and hepatic involvement are common features. Nineteen CF-patients with typical pulmonary and pancreatic symptoms were compared with 41 healthy children with normal development, height and weight. At the time studied the CF-patients were all clinically stable without signs of diabetes or hepatic involvement. The age distribution was equal for C F and normals (N: 155f26 months-CF: 156f29 months ( X f 2 SD)). All samples were obtained between 9 and 10 a.m. and promptly centrifuged and stored at -8OC until assayed. A modified analysis of sulphate incorporation in the pelvic cartilage of 12-day-old chick embryos was utilized (2). In spite of improved management of pulmonary and pancreatic complications in CF, retardation of skeletal growth is still a common manifestation of the disease (3), reported not to be confined to those with severe malabsorbtion or lung complications (4). The growth hormone levels have been reported normal or elevated (549, and other hormones influencing the growth and growth spurt have been reported normal including, thyroid hormones and gonadal and adrenal steroids (9-13). Recently two separate somatomedin studies have been reported (7, 14). By using bioassay in six patients with C F Lee et al. (14) demonstrated reduction of somatomedin activity to about 50% of values in normal children. The opposite result was obtained by Rosenfeld et al. (7), using placental membrane radioreceptor assay in measuring total somatomedin peptide content in plasma of 15 C F patients. The conflicting results have been discussed by the latter group. The presence of a circulating somatomedin inhibitor, whose existence might be secondary to either malnutrition or to an underlying metabolic defect in CF, is mentioned. Our results, showing normal somatomedin activity in C F patients (Fig. I ) , using a welldocumented bioassay (2), are however similar to the results presented by Rosenfeld et al. (7), suggesting normal generation of normally","PeriodicalId":75407,"journal":{"name":"Acta paediatrica Scandinavica","volume":"72 5","pages":"757-8"},"PeriodicalIF":0.0,"publicationDate":"1983-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1111/j.1651-2227.1983.tb09807.x","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17693552","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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