{"title":"Advantages of neutron scattering for biological structure analysis.","authors":"B P Schoenborn","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":75624,"journal":{"name":"Brookhaven symposia in biology","volume":" 27","pages":"110-117"},"PeriodicalIF":0.0,"publicationDate":"1976-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12146094","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Neutron diffraction studies of vertebrate striated muscle.","authors":"D L Worcester, J M Gillis, E J O'Brien, K Ibel","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":75624,"journal":{"name":"Brookhaven symposia in biology","volume":" 27","pages":"III101-III114"},"PeriodicalIF":0.0,"publicationDate":"1976-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12146240","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Small-angle scattering of proteins in solution.","authors":"H B Stuhrmann","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":75624,"journal":{"name":"Brookhaven symposia in biology","volume":" 27","pages":"IV3-IV19"},"PeriodicalIF":0.0,"publicationDate":"1976-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12146246","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
In this paper the methods and techniques of neutron diffraction studies of biological membranes and membrane components have been described and demonstrated. Foremost among these are the methods of deuterium exchange and deuterium labeling, since they can directly provide locations of membrane components. In addition, the methods of contrast variation with H2O-D2O mixtures, swelling, direct scaling of data from deuterium-labeled structures, and magnetic orientation have provided useful information in neutron diffraction analyses of membrane structures. Although this field is only in its infancy, it clearly has very encouraging prospects.
{"title":"Neutron diffraction studies of biological membranes and membrane components.","authors":"D L Worcester","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>In this paper the methods and techniques of neutron diffraction studies of biological membranes and membrane components have been described and demonstrated. Foremost among these are the methods of deuterium exchange and deuterium labeling, since they can directly provide locations of membrane components. In addition, the methods of contrast variation with H2O-D2O mixtures, swelling, direct scaling of data from deuterium-labeled structures, and magnetic orientation have provided useful information in neutron diffraction analyses of membrane structures. Although this field is only in its infancy, it clearly has very encouraging prospects.</p>","PeriodicalId":75624,"journal":{"name":"Brookhaven symposia in biology","volume":" 27","pages":"III37-III57"},"PeriodicalIF":0.0,"publicationDate":"1976-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12009113","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Development of large-area, position-sensitive neutron detectors.","authors":"J L Alberi","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":75624,"journal":{"name":"Brookhaven symposia in biology","volume":" 27","pages":"VIII24-VIII42"},"PeriodicalIF":0.0,"publicationDate":"1976-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12146082","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
An area detector for thermal neutrons based on image intensification techniques has been described. Some capabilities and limitations of the detection system have been discussed. Among the former are high spatial resolution, high instantaneous counting rate, electronic zoom, time-gating, and integration. The detector is limited in that the maximum counting rate for a resolution element is 60 regularly spaced counts per second. Also, the nonuniformity of response over the detector puts a limit on the useful size and necessitates point-by-point calibration. In addition, a higher efficiency for neutron detection would be desirable. Some typical applications of the system are crystal inspection, neutron magnetic diffraction topography, and searches for temperature-induced changes in diffraction patterns. The future application of solid-state television sensors and microchannel-plate intensifiers to improve the system were briefly mentioned.
{"title":"Fly's eye: a counting camera for thermal neutrons-some applications, problems, and prospects.","authors":"J P Davidson","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>An area detector for thermal neutrons based on image intensification techniques has been described. Some capabilities and limitations of the detection system have been discussed. Among the former are high spatial resolution, high instantaneous counting rate, electronic zoom, time-gating, and integration. The detector is limited in that the maximum counting rate for a resolution element is 60 regularly spaced counts per second. Also, the nonuniformity of response over the detector puts a limit on the useful size and necessitates point-by-point calibration. In addition, a higher efficiency for neutron detection would be desirable. Some typical applications of the system are crystal inspection, neutron magnetic diffraction topography, and searches for temperature-induced changes in diffraction patterns. The future application of solid-state television sensors and microchannel-plate intensifiers to improve the system were briefly mentioned.</p>","PeriodicalId":75624,"journal":{"name":"Brookhaven symposia in biology","volume":" 27","pages":"VIII3-VIII15"},"PeriodicalIF":0.0,"publicationDate":"1976-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12146083","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The field of neutron inelastic scattering has probably been developed to the stage where it can begin to help the biologist. Because essentially no experimental data have been obtained, it is difficult either to draw conclusions or to make forecasts except on the basis of general hypotheses. It seems likely, however, that the next stage is up to biologists. After reviewing those biological problems in which molecular dynamics might play an important role, they should suggest specimens of interest which can give inelastic peaks with existing spectrometers operating with 5 to 10-A neutrons at angles greater than 5degrees and with resolutions of approximately 50 mueV. These specimens may involve molecules slightly smaller and more mobile than some biologists would like, but a successful outcome might lead to the development of spectrometers capable of working in a more satisfactory range. In this event the return may well prove rewarding to the biologists.
{"title":"Inelastic scattering of neutrons and possible biological applications.","authors":"P A Egelstaff","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The field of neutron inelastic scattering has probably been developed to the stage where it can begin to help the biologist. Because essentially no experimental data have been obtained, it is difficult either to draw conclusions or to make forecasts except on the basis of general hypotheses. It seems likely, however, that the next stage is up to biologists. After reviewing those biological problems in which molecular dynamics might play an important role, they should suggest specimens of interest which can give inelastic peaks with existing spectrometers operating with 5 to 10-A neutrons at angles greater than 5degrees and with resolutions of approximately 50 mueV. These specimens may involve molecules slightly smaller and more mobile than some biologists would like, but a successful outcome might lead to the development of spectrometers capable of working in a more satisfactory range. In this event the return may well prove rewarding to the biologists.</p>","PeriodicalId":75624,"journal":{"name":"Brookhaven symposia in biology","volume":" 27","pages":"126-137"},"PeriodicalIF":0.0,"publicationDate":"1976-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12146097","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
A Miller, B B Doyle, D J Hulmes, G T Jenkins, J W White, J Haas, K Ibel, P Timmins
{"title":"Neutron scattering by Collagen.","authors":"A Miller, B B Doyle, D J Hulmes, G T Jenkins, J W White, J Haas, K Ibel, P Timmins","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":75624,"journal":{"name":"Brookhaven symposia in biology","volume":" 27","pages":"III86-III100"},"PeriodicalIF":0.0,"publicationDate":"1976-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12168493","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"The specificity of RNase III cleavage of bacteriophage T7 early messenger RNAs.","authors":"M Rosenberg, R A Kramer, J A Steitz","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":75624,"journal":{"name":"Brookhaven symposia in biology","volume":" 26","pages":"277-85"},"PeriodicalIF":0.0,"publicationDate":"1975-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12283476","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Mapping of viral-specific RNA in the cytoplasm and nucleus of adenovirus 2-infected human cells.","authors":"S J Flint, P A Sharp","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":75624,"journal":{"name":"Brookhaven symposia in biology","volume":" 26","pages":"333-58"},"PeriodicalIF":0.0,"publicationDate":"1975-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12283478","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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