Alternative therapies in health and medicine最新文献

Background: Although epidemiological and preclinical research suggests that the polyamine spermidine improves the efficiency of autophagy, human clinical research demonstrating a specific dose of any source of spermidine capable of increasing biomarkers of autophagy is lacking.

Primary study objective: The study aimed to examine the effects of spermidine from Miricell™ rice germ extract (Nutraland USA) on biomarkers/indices of autophagy, neuroprotection, and cardiometabolic health, as well as safety and adverse events.

Methods/design: This 56-day study was conducted as a single-blinded, interventional, parallel-group, pilot trial. Vitals, diet records, and protocol compliance were recorded at weeks 0 and 8. Blood draws for cardiometabolic markers and adverse event monitoring took place at screening and weeks 0 and 8.

Setting: Conducted at a clinical research laboratory in Ohio.

Participants: Twelve (N=12) healthy men and women (age: 54.5 ± 7.9 years).

Intervention: Random assignment to 1.5 mg or 3.3 mg of spermidine daily from Miricell™ rice germ extract (Nutraland USA).

Primary outcome measures: Biomarkers of autophagy [Beclin-1 and Unc-51-like kinase 1(ULK1)], and biomarkers/indices of neuroprotection, including brain-derived neurotrophic factor (BDNF), homocysteine, and cardiometabolic health (high sensitivity C-reactive protein (hs-CRP), lipid panel).

Results: Compared to baseline, only the 3.3 mg dose of spermidine from Miricell® increased Beclin-1 by 7.3%, ULK-1 by 13.4%, and BDNF by 12.1%. Compared to baseline, the same dose resulted in a 20.8% decrease in hs-CRP, a 20.1% decrease in VLDL, and a 26.9% decrease in triglycerides. Secondary outcomes, including clinical chemistry panel, CBC, vital signs, and adverse events, reflect a good safety profile for the use of 3.3 mg/day of spermidine from Miricell®.

Conclusion: This pilot study found that 3.3 mg/day of spermidine from Miricell® rice germ extract tends to improve biomarkers of autophagy, neuroprotection, and cardiometabolic health. Appropriate follow-up studies are warranted to confirm these findings.

Keywords: spermidine, autophagy, beclin-1, ULK1, rice germ extract, neuroprotection, BDNF, homocysteine, cardiometabolic, CRP, C-reactive protein, VLDL, triglycerides, aging.

No Abstract Available.

Context: Pediatric purulent tonsillitis is a common infectious disease in children and can be difficult to cure and can recur with irritation of the throat. To improve treatment outcomes, alleviate symptoms, and promote recovery, an effective clinical-nursing intervention is often necessary.

Objective: The study aimed to explore the specific measures of the comprehensive nursing model for pediatric patients with purulent tonsillitis and to analyze its practical value in improving patients' treatment outcomes and quality of life (QoL) in clinical application, to provide feasible references and guidance for medical practice.

Design: The research team conducted a randomized controlled trial.

Setting: The study took place at Mengcheng County First People's Hospital.

Participants: Participants were 80 pediatric patients who had received a diagnosis of purulent tonsillitis at the hospital between December 2020 and March 2022.

Interventions: The research team randomly divided participants into two groups, with 40 participants in each group: (1) the intervention group, who received comprehensive nursing care in addition to routine nursing care, and (2) the control group, who received routine nursing care only.

Outcome measures: The research team: (1) evaluated times to relief of throat pain and to improvement of hoarseness, (2) assessed times to recovery of body temperature, white blood cells, and tonsillar signs, (3) measured treatment compliance, and (4) conducted a health knowledge survey with the children' family members at baseline and postintervention using a visual analogue scale (VAS).

Results: Compared to control group, the intervention group's (1) times to relief of throat pain and improvement time of hoarseness were significantly shorter (both P < .05); (2) times to recovery of temperature (P = .002), white blood cells (P = .006), and tonsillar signs (P = .024) were significantly shorter; (3) treatment compliance was significantly higher (P = .021); and (4) level of health knowledge of family members was significantly higher (P < .001).

Conclusions: The comprehensive nursing model for pediatric purulent tonsillitis can effectively improve pediatric patients' treatment outcomes, shorten their recovery times, enhance the health knowledge of family members, and provide a better focus on the overall health of pediatric patients. The model has a positive significance for pediatric patients' rehabilitation and is worth promoting.

Keywords: pediatric purulent tonsillitis, clinical, comprehensive nursing model, measures, application value.

Aim: This study explores the mechanisms underlying the impact of a combined intervention using maternal voice stimulation (MSS) and non-nutritive sucking (NSS) on feeding intolerance and growth and development in premature infants.

Method: One hundred cases of low birth weight premature infants admitted between August 2021 and December 2022 were randomly assigned into two groups: the combined group and the control group, each consisting of 50 infants. The control group received a non-nutritive sucking intervention, while the combined group received maternal voice stimulation in addition to the sucking intervention. Differences in feeding intolerance, feeding progression, growth and development, feeding performance, and heart rate indices were compared between the groups.

Results: Compared to the control group, the combined group showed significantly reduced incidence of feeding intolerance, feeding transition time, length of hospital stay, and time to regain birth weight, along with lowered heart rate. Additionally, there were significant increases in body mass growth rate, head circumference growth rate, body length growth rate, milk intake ratio, and feeding efficiency in the combined group (P < .05).

Conclusion: The application of maternal voice stimulation combined with non-nutritive sucking in premature infants could reduce the risk of feeding intolerance and heart rate levels. Simultaneously, it improved feeding performance and promoted growth and development in premature infants, indicating the clinical value and potential applicability of this combined intervention.

Keywords: maternal voice stimulation, non-nutritive sucking, premature infants, feeding intolerance, growth and development, heart rate.

Background: De Quervain's tenosynovitis (DQT) is an inflammatory condition affecting the abductor pollicis longus and extensor pollicis brevis tendon sheaths at the radial styloid. It can impair hand function, reduce quality of life, and hinder occupational performance. Although multiple treatments exist, there is limited consensus on the most effective therapeutic strategy.

Primary study objective: To compare the effects of ultrasound therapy versus low-level laser therapy in DQT patients.

Methods/design: A single-blinded randomized clinical trial was conducted.

Setting: The study was conducted in the physiotherapy department of a hospital for a total duration of 4 weeks.

Participants: Seventy-two patients diagnosed with DQT, randomly assigned to Group A (n = 36) and Group B (n = 36).

Intervention: Group A received low-level laser therapy twice weekly for 4 weeks, while Group B received ultrasound therapy twice weekly for 4 weeks.

Primary outcome measures: We used the visual analogue scale and patient-rated wrist evaluation as outcome measures to assess pain and wrist disability, respectively. We collected the data at baseline, at the end of the 2nd week, and after the completion of the 4th week.

Results: Both groups showed significant within-group reductions in VAS scores over the 4-week treatment period (P = .00). However, at the 4th week, the low-level laser therapy group demonstrated significantly greater pain reduction compared to the ultrasound group (P = .00).

Conclusion: The study concluded that low-level laser therapy is significantly more effective at reducing wrist disability but not pain as compared to ultrasound therapy in the DQT.

Keywords: Comparative study, de Quervain's stenosing tenosynovitis, Low-level laser therapy, Physical medicine, Therapeutic ultrasound.

Background: This manuscript describes a newly developed Meditation protocol that has emerged through personal experience of the author over an extended period. Rooted in traditional mindfulness practices but adapted through lived experience, this protocol offers a unique approach to Meditation, aiming to foster cognition, deeper self-awareness, and emotional balance. Unlike other protocols grounded in formal research, this practice is shaped by intuitive insights and personal exploration.

Objective: The primary objective of the novel Pranchakra Meditation is to enhance the practitioner engagement (such as maintaining focus) and foster regular practice along with providing health benefits (such as managing stress).

Methodology: Pranchakra Meditation is a combination practice including pranayama, dhyana, and bandha of Indian traditional yogic origin. The author utilizes personal academic and professional expertise, focus group discussion, and thematic analysis to design the protocol including five practicing academicians in the field of Yoga and Naturopathy and three independent Yoga practitioners.

Results: Preliminary anecdotal feedback suggests that practitioners experience enhanced clarity and relaxation. The protocol showed strong validation overall, with most criteria receiving ≥75% agreement. Feedback highlighted the protocol effectiveness in maintaining engagement.

Conclusion: Pranchakra Meditation represents a promising tool in Meditation practice, although further research is necessary to validate its broader applicability. This protocol has the potential to contribute significantly to the evolving landscape of meditative practices and invites future studies for formal validation.

Keywords: Meditation, Pranayama, Yoga, Bandha, Pranchakra, Protocol design.

Objective: The study aimed to investigate the factors influencing the efficacy of Shenqi Yanshen Granule in ameliorating proteinuria among nephrotic syndrome patients in renal function stages 1-3.

Methods: 100 patients with nephrotic syndrome and renal function stages 1-3, treated at our hospital from May 2021 to March 2023 were enrolled. All patients received Shenqi Yanshen granule treatment. The patients were divided into the control group (n = 68, with proteinuria reduction of ≥50%) and the observation group (n = 32, with proteinuria reduction of <50% or increased proteinuria) at 24 hours after treatment. Clinical data, proteinuria levels at 24 hours after treatment, renal function indices, and mean blood pressure were statistically compared. The efficacy of Shenqi Yanshen Granule in treating proteinuria and factors influencing the efficacy was assessed using multiple logistic regression.

Results: The observation group had a higher average age and duration of disease compared to the control group (P < .05). Upon treatment, proteinuria decreased in both groups (P < .05), with higher levels in the observation group than in the control group. Post-treatment, serum creatinine levels decreased and GFR increased in the control group (P < .05), while the serum creatinine level increased and GFR decreased in the observation group (P < .05). Mean blood pressure decreased in both groups post-treatment (P < .05). The observation group exhibited lower rates of remarkable and effective outcomes and higher rates of general effective and ineffective outcomes (P < .05). Logistic regression analysis highlighted age, severity of nephropathy, underlying conditions, lifestyle, and pre-treatment proteinuria as significant factors influencing the impact of Shenqi Yanshen Granule on proteinuria in patients with nephrotic syndrome (P < .05).

Conclusion: Shenqi Yanshen Granule proves to be a potent intervention for reducing proteinuria in patients with nephrotic syndrome. Notably, age and disease severity emerge as pivotal determinants of drug efficacy.

Keywords: Shenqi Yanshen Granule, Nephrotic syndrome, Proteinuria, Influencing factors of curative effect.

Background: The Unani system of medicine is rooted in the Theory of Humors, where health is maintained through the balance of four bodily fluids (blood, phlegm, bile, and black bile). Its treatment approach is holistic, encompassing Ilaj bil Tadbeer (Regimental therapy), Ilaj bil Ghida (Dietotherapy), Ilaj bil Dawa (Pharmacotherapy), and Ilaj bil Yad (Surgery). Huqna (enema) is a key non-pharmacological regimen therapy in Unani medicine, used to cleanse the bowels and restore humoral balance. Its roots trace back to ancient Greek physicians like Hippocrates and Galen.

Objectives: This integrative review aims to provide a comprehensive understanding of Huqna therapy, exploring its historical, philosophical, and practical aspects while bridging traditional Unani practices with modern medical paradigms.

Materials and methods: A review of classical Unani literature and modern scientific sources was conducted. Historical texts were analyzed alongside contemporary studies on enema therapy in modern medicine. Relevant English-language literature up to 2024 was evaluated.

Results: The study highlights the definition, principles, and therapeutic applications of Huqna in traditional Unani medicine and compares them with the diagnostic and therapeutic uses of enemas in modern healthcare. Key convergences include their shared utility in managing bowel disorders and inflammatory conditions, while divergences emerge in procedural advancements and safety considerations.

Conclusion: Huqna therapy demonstrates significant potential as a complementary approach in modern healthcare. However, further research is needed to validate its efficacy and address limitations. This analysis fosters a deeper understanding of Huqna therapy, encouraging its integration into contemporary medical practice.

Keywords: Huqna, Enema, Unani Medicine, Integrative Medicine, Traditional Therapy.

Objective: To explore the effect of feedforward control and control system on reducing postpartum hemorrhage (PPH) rate in primary hospitals.

Methods: Multi-period PPH special training classes were held in five primary hospitals, such as the Ruyuan Yao Autonomous County People's Hospital, Wengyuan County People's Hospital, located in Shaoguan, Guangdong, China, from 2017 to 2018. In this study, theoretical teaching combined with practical operations were performed. Clinical case-control analysis of PPH risk before and after PPH training was carried out.

Results: After training, the overall incidence of PPH decreased by 0.44% in the five hospitals (χ2 = 7.16, P = .007), the incidence of PPH in natural delivery decreased by 0.47% (χ2 = 5.41, P = .02), and decreased by 0.37% in cesarean section (χ2 = 1.86, P = .173). Uterine atony was the most common cause of PPH, but placental factors caused greater amount of delivery hemorrhage and bleeding 24 hours after delivery in the cases of PPH than uterine atony.

Conclusion: Adopting feedforward control management and constructing a control system in Shaoguan primary hospitals could effectively reduce the incidence of PPH. It is imperative to strengthen the training of pregnancy management and hemostasis surgery for pregnant women with placental factors.

Keywords: PPH, primary hospitals, feedforward control, control system.

Background: Autism spectrum disorder (ASD), marked by social communication deficits and repetitive behaviors, significantly impacts the quality of life for kids and caregivers. Herbal medicines help manage symptoms, yet no comprehensive review has collectively summarized recent evidence (2018-mid-2025).

Methods: This narrative review utilized searches across PubMed, Scopus, Web of Science, and Google Scholar to identify studies published on herbal medicines for ASD. Inclusion criteria prioritized clinical trials and preclinical studies detailing plant bioactive compounds, dosing, and mechanisms.

Key findings: Prominent herbs include Bacopa monnieri, which can enhance cognitive flexibility via bacosides; Curcuma longa (curcumin), which can reduce oxidative stress and repetitive behaviors; and Green Tea Extract (luteolin), which can modulate neuroinflammation. Cannabinoids show modest improvements in sleep and social engagement, while Ginkgo biloba improves cerebral blood flow. Passionflower and Valerian Root alleviate anxiety and hyperactivity through GABAergic pathways, and probiotic-fermented herbal combinations target gut-brain axis dysfunction. Ashwagandha demonstrates neuroprotective effects in preclinical trials.

Clinical implications: Herbal therapies may address core ASD symptoms (anxiety and hyperactivity) and comorbidities (sleep disturbances and gastrointestinal issues). However, standardization of herbal formulations and rigorous dosing protocols are needed. Integrative approaches combining herbs with behavioral therapies show accepted synergistic potential but require further validation. While herbal medicine may offer supportive benefits, it should never be intended to replace other evidence-based therapies (e.g., applied behavior analysis and speech therapy).

Future directions: Large-scale randomized clinical trials are crucial to confirming efficacy, safety, and optimal dosing. Research must address herb-drug interactions, long-term effects, and biomarkers for personalized treatment.

Keywords: autism spectrum disorder, herbal medicines, narrative review, doses recommendation, therapeutic effects, side effects.