Objective: To analyze the effectiveness of preventive nursing interventions in patients on hemodialysis with arteriovenous fistulas (AVF) and the value in preventing complications of the AVF.
Method: It was a randomized controlled trial that enrolled 60 patients on hemodialysis treated in our hospital from April 2019 to May 2021. All enrollments were divided into control group (n = 30) and study group (n = 30) by random table methods. The control group received conventional nursing methods, while the study group received preventive nursing methods. The incidence of AVF complications, blood flow in the AVF, levels of anxiety and depression, quality of life and nursing satisfaction were assessed and compared.
Results: The incidence of AVF complications in the study group after intervention was significantly lower than that in the control group. Blood flow in the AVF was much higher in the study group than in the control group. The anxiety and depression levels of patients in the study group after intervention were both lower than those of patients in the control group. Patients in the study group had a much better quality of life after intervention than those in the control group. The nursing satisfaction of patients in the study group after intervention was also higher than that of patients in the control group. In other words, patients in the study group were more satisfied with the way they had been cared for compared to those in the control group.
Conclusion: Preventive nursing interventions are effective in patients on hemodialysis. Not only do they reduce the incidence of AVF complications, they also improve blood flow in the AVF. In addition, they reduce such negative emotions as anxiety and depression, improves the patient's quality of life, as well as his or her satisfaction with care provision.
{"title":"The Effectiveness of Preventive Nursing Interventions in Patients on Hemodialysis with Arteriovenous Fistulas and Their Value in Preventing Complications.","authors":"Liang Yu, Xinghong Xu","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Objective: </strong>To analyze the effectiveness of preventive nursing interventions in patients on hemodialysis with arteriovenous fistulas (AVF) and the value in preventing complications of the AVF.</p><p><strong>Method: </strong>It was a randomized controlled trial that enrolled 60 patients on hemodialysis treated in our hospital from April 2019 to May 2021. All enrollments were divided into control group (n = 30) and study group (n = 30) by random table methods. The control group received conventional nursing methods, while the study group received preventive nursing methods. The incidence of AVF complications, blood flow in the AVF, levels of anxiety and depression, quality of life and nursing satisfaction were assessed and compared.</p><p><strong>Results: </strong>The incidence of AVF complications in the study group after intervention was significantly lower than that in the control group. Blood flow in the AVF was much higher in the study group than in the control group. The anxiety and depression levels of patients in the study group after intervention were both lower than those of patients in the control group. Patients in the study group had a much better quality of life after intervention than those in the control group. The nursing satisfaction of patients in the study group after intervention was also higher than that of patients in the control group. In other words, patients in the study group were more satisfied with the way they had been cared for compared to those in the control group.</p><p><strong>Conclusion: </strong>Preventive nursing interventions are effective in patients on hemodialysis. Not only do they reduce the incidence of AVF complications, they also improve blood flow in the AVF. In addition, they reduce such negative emotions as anxiety and depression, improves the patient's quality of life, as well as his or her satisfaction with care provision.</p>","PeriodicalId":7571,"journal":{"name":"Alternative therapies in health and medicine","volume":null,"pages":null},"PeriodicalIF":1.9,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138796151","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Jiao Wang, Qingqing Zhang, Bo Miao, Jiangman Cui, Xuehong Du, Xin Li
<p><strong>Objective: </strong>Exploring the clinical efficacy of neomycin and sakubactria valsartan in the treatment of patients with chronic heart failure (CHF) and atrial fibrillation. This study investigates the potential benefits of combining neomycin with sakubactria valsartan, a medication with a background of demonstrated efficacy in cardiovascular conditions, to address the complex challenges presented by chronic heart failure and atrial fibrillation.</p><p><strong>Methods: </strong>Using a single-center clinical randomized trial, 111 patients with CHF complicated with atrial fibrillation who were treated in the cardiovascular department of Xingtai Third Hospital from June 2019 to March 2021 were randomly divided into two groups. In the control group, 56 patients received treatment with Western Medicine Foundation + Shakubatra valsartan. In the experimental group, consisting of 55 patients, the treatment was identical to the control group, with the additional administration of neomycin.. After 12 weeks of continuous treatment, the echocardiograms, electrocardiogram parameters, and Differences in changes in serum soluble growth stimulating gene 2 protein (sST2) and galactose agglutinin 3 (Gal-3), clinical efficacy, and incidence of adverse reactions.</p><p><strong>Results: </strong>Before treatment, no significant differences existed in LVEF, LVEDV, FS, and SV between the experimental and control groups (P > .05). Post-treatment, both groups exhibited significant improvements in these parameters, with the experimental group showing statistically higher values (P < .05).Similarly, pre-treatment comparisons of Pd, sST2, Gal-3, and NT-proBNP revealed no significant differences between the groups (P > .05). After treatment, both groups showed significant reductions, with the experimental group demonstrating lower values (P < .05).Clinical efficacy assessment post-treatment showed significant differences. The experimental group had a basic cure rate of 45.45%, a significant effective rate of 43.64%, and an effective rate of 10.91%, while the control group had rates of 28.57%, 48.21%, and 23.21%, respectively (P < .05).Adverse reactions occurred in 9 and 4 patients in the experimental and control groups, respectively. The severity was not significant, and treatment was uninterrupted (P > 0.05).The treatment improved heart function and reduced atrial fibrillation occurrences, holding clinical significance by potentially enhancing patients' quality of life and decreasing cardiovascular events. These results highlight the clinical significance of this treatment, which may help improve patients' quality of life and reduce the occurrence of cardiovascular events.</p><p><strong>Conclusion: </strong>The treatment of patients with CHF combined with atrial fibrillation using neomycin and sakubactria valsartan can more effectively improve their cardiac function and alleviate the condition of atrial fibrillation, which is worthy of clinical promotion and
{"title":"The Efficacy and Mechanism of Xinhuosun + Shakubatra valsartan in the Treatment of CHF Patients with Atrial Fibrillation.","authors":"Jiao Wang, Qingqing Zhang, Bo Miao, Jiangman Cui, Xuehong Du, Xin Li","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Objective: </strong>Exploring the clinical efficacy of neomycin and sakubactria valsartan in the treatment of patients with chronic heart failure (CHF) and atrial fibrillation. This study investigates the potential benefits of combining neomycin with sakubactria valsartan, a medication with a background of demonstrated efficacy in cardiovascular conditions, to address the complex challenges presented by chronic heart failure and atrial fibrillation.</p><p><strong>Methods: </strong>Using a single-center clinical randomized trial, 111 patients with CHF complicated with atrial fibrillation who were treated in the cardiovascular department of Xingtai Third Hospital from June 2019 to March 2021 were randomly divided into two groups. In the control group, 56 patients received treatment with Western Medicine Foundation + Shakubatra valsartan. In the experimental group, consisting of 55 patients, the treatment was identical to the control group, with the additional administration of neomycin.. After 12 weeks of continuous treatment, the echocardiograms, electrocardiogram parameters, and Differences in changes in serum soluble growth stimulating gene 2 protein (sST2) and galactose agglutinin 3 (Gal-3), clinical efficacy, and incidence of adverse reactions.</p><p><strong>Results: </strong>Before treatment, no significant differences existed in LVEF, LVEDV, FS, and SV between the experimental and control groups (P > .05). Post-treatment, both groups exhibited significant improvements in these parameters, with the experimental group showing statistically higher values (P < .05).Similarly, pre-treatment comparisons of Pd, sST2, Gal-3, and NT-proBNP revealed no significant differences between the groups (P > .05). After treatment, both groups showed significant reductions, with the experimental group demonstrating lower values (P < .05).Clinical efficacy assessment post-treatment showed significant differences. The experimental group had a basic cure rate of 45.45%, a significant effective rate of 43.64%, and an effective rate of 10.91%, while the control group had rates of 28.57%, 48.21%, and 23.21%, respectively (P < .05).Adverse reactions occurred in 9 and 4 patients in the experimental and control groups, respectively. The severity was not significant, and treatment was uninterrupted (P > 0.05).The treatment improved heart function and reduced atrial fibrillation occurrences, holding clinical significance by potentially enhancing patients' quality of life and decreasing cardiovascular events. These results highlight the clinical significance of this treatment, which may help improve patients' quality of life and reduce the occurrence of cardiovascular events.</p><p><strong>Conclusion: </strong>The treatment of patients with CHF combined with atrial fibrillation using neomycin and sakubactria valsartan can more effectively improve their cardiac function and alleviate the condition of atrial fibrillation, which is worthy of clinical promotion and ","PeriodicalId":7571,"journal":{"name":"Alternative therapies in health and medicine","volume":null,"pages":null},"PeriodicalIF":1.9,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139641474","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Objective: This study aimed to evaluate the impact of exercise and respiratory training for chronic obstructive pulmonary disease (COPD) patients on specific COPD-related outcomes, such as lung function, exercise capacity, and patient prognosis.
Methods: This work had a retrospective design. The subjects of this study were 90 patients with COPD who were treated in our hospital from May 2020 to May 2021. The patients were divided into two groups according to whether they performed exercise combined with respiratory training based on conventional treatment. After two weeks of intervention, the difference in rehabilitation outcomes between the two groups was detected at the first and third months after discharge.
Results: The rehabilitation compliance of the observation group was significantly higher than that of the control group (95.56% vs. 77.78%, P < .05). The forced expiratory volume in one second (FEV1) (2.66±0.71 vs. 2.28±0.48, P = .004), forced vital capacity (FVC) (3.30±0.70 vs. 3.00±0.63, P = .035), FEV1/FVC (80.61±8.01% vs. 76.77±7.34%, P = .020), maximal ventilation volume per minute (MVV) (96.14±3.50 vs. 91.20±4.97, P < .001), partial pressure of blood oxygen (PaO2) (89.52±6.87 vs. 82.65±6.54, P < .001), and oxygen saturation of blood (SaO2) (98.05±1.27 vs. 95.90±1.42, P < .001) in the observation group were significantly higher than those in the control group. In contrast, arterial partial pressure of carbon dioxide (PaCO2) (39.52±1.66 vs. 43.21±2.01, P < .001) was significantly lower than that in the control group. The observation group's 6-minute walking distance (6MWD) (401.05±65.66 vs. 360.25±54.94, P = .002) after treatment was significantly longer than those of the control group. The acute exacerbation rate (6.67% vs. 20.00%, P = .036), rehospitalization rate (4.44% vs. 17.78%, P = .044), and mortality rate (0.00% vs. 8.89%, P = .041) of the observation group were lower than those of the control group.
Conclusion: The application of exercise training combined with respiratory training in the rehabilitation treatment of COPD patients can more effectively promote the improvement of lung function, blood gas indexes, exercise endurance, and respiratory function and can improve the symptoms of dyspnea, with a good prognosis. This study confirmed the additional health benefits of exercise/respiratory training for COPD patients and provides evidence for the application of exercise/respiratory training in clinical practice. Therefore, it is recommended that in clinical practice, the necessity of exercise/respiratory training in COPD patients needs to be considered. However, the duration of intervention and follow-up period in this study were short, and longer intervention and follow-up are still needed to further confirm the results of this study.
研究目的本研究旨在评估慢性阻塞性肺病（COPD）患者的运动和呼吸训练对肺功能、运动能力和患者预后等特定 COPD 相关结果的影响：本研究采用回顾性设计。研究对象为2020年5月至2021年5月在我院接受治疗的90名慢性阻塞性肺疾病患者。根据患者是否在常规治疗的基础上进行运动结合呼吸训练，将其分为两组。干预两周后，检测两组患者出院后第1个月和第3个月的康复效果差异：结果：观察组的康复依从性明显高于对照组（95.56% 对 77.78%，P < .05）。观察组的血氧分压（PaO2）（89.52±6.87 vs. 82.65±6.54，P＜0.001）和血氧饱和度（SaO2）（98.05±1.27 vs. 95.90±1.42，P＜0.001）明显高于对照组。相比之下，观察组的动脉二氧化碳分压（PaCO2）（39.52±1.66 vs. 43.21±2.01，P < .001）明显低于对照组。观察组治疗后的 6 分钟步行距离（6MWD）（401.05±65.66 vs. 360.25±54.94，P = .002）明显长于对照组。观察组的急性加重率（6.67% vs. 20.00%，P = .036）、再住院率（4.44% vs. 17.78%，P = .044）和死亡率（0.00% vs. 8.89%，P = .041）均低于对照组：结论：在慢性阻塞性肺疾病患者的康复治疗中应用运动训练联合呼吸训练，能更有效地促进肺功能、血气指标、运动耐力和呼吸功能的改善，并能改善呼吸困难症状，预后良好。本研究证实了运动/呼吸训练对慢性阻塞性肺疾病患者的额外健康益处，为运动/呼吸训练在临床实践中的应用提供了证据。因此，建议在临床实践中需要考虑对慢性阻塞性肺病患者进行运动/呼吸训练的必要性。然而，本研究的干预时间和随访时间较短，仍需更长时间的干预和随访来进一步证实本研究的结果。
{"title":"Clinical Effects of Exercise Combined with Respiratory Training in the Rehabilitation Treatment of Patients with Chronic Obstructive Pulmonary Disease.","authors":"Ling Wang, Xinyu Wu","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Objective: </strong>This study aimed to evaluate the impact of exercise and respiratory training for chronic obstructive pulmonary disease (COPD) patients on specific COPD-related outcomes, such as lung function, exercise capacity, and patient prognosis.</p><p><strong>Methods: </strong>This work had a retrospective design. The subjects of this study were 90 patients with COPD who were treated in our hospital from May 2020 to May 2021. The patients were divided into two groups according to whether they performed exercise combined with respiratory training based on conventional treatment. After two weeks of intervention, the difference in rehabilitation outcomes between the two groups was detected at the first and third months after discharge.</p><p><strong>Results: </strong>The rehabilitation compliance of the observation group was significantly higher than that of the control group (95.56% vs. 77.78%, P < .05). The forced expiratory volume in one second (FEV1) (2.66±0.71 vs. 2.28±0.48, P = .004), forced vital capacity (FVC) (3.30±0.70 vs. 3.00±0.63, P = .035), FEV1/FVC (80.61±8.01% vs. 76.77±7.34%, P = .020), maximal ventilation volume per minute (MVV) (96.14±3.50 vs. 91.20±4.97, P < .001), partial pressure of blood oxygen (PaO2) (89.52±6.87 vs. 82.65±6.54, P < .001), and oxygen saturation of blood (SaO2) (98.05±1.27 vs. 95.90±1.42, P < .001) in the observation group were significantly higher than those in the control group. In contrast, arterial partial pressure of carbon dioxide (PaCO2) (39.52±1.66 vs. 43.21±2.01, P < .001) was significantly lower than that in the control group. The observation group's 6-minute walking distance (6MWD) (401.05±65.66 vs. 360.25±54.94, P = .002) after treatment was significantly longer than those of the control group. The acute exacerbation rate (6.67% vs. 20.00%, P = .036), rehospitalization rate (4.44% vs. 17.78%, P = .044), and mortality rate (0.00% vs. 8.89%, P = .041) of the observation group were lower than those of the control group.</p><p><strong>Conclusion: </strong>The application of exercise training combined with respiratory training in the rehabilitation treatment of COPD patients can more effectively promote the improvement of lung function, blood gas indexes, exercise endurance, and respiratory function and can improve the symptoms of dyspnea, with a good prognosis. This study confirmed the additional health benefits of exercise/respiratory training for COPD patients and provides evidence for the application of exercise/respiratory training in clinical practice. Therefore, it is recommended that in clinical practice, the necessity of exercise/respiratory training in COPD patients needs to be considered. However, the duration of intervention and follow-up period in this study were short, and longer intervention and follow-up are still needed to further confirm the results of this study.</p>","PeriodicalId":7571,"journal":{"name":"Alternative therapies in health and medicine","volume":null,"pages":null},"PeriodicalIF":1.9,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138795968","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Background: Emergency transfusion is a frequently performed invasive medical procedure. Patients often experience negative emotions and exhibit poor compliance during transfusion. Therefore, it is imperative to proactively implement effective nursing interventions.
Objective: This study aims to investigate the impact of a humanized nursing model on the nursing outcomes of emergency transfusion patients.
Design: This research was conducted as a randomized controlled experiment.
Setting: The study was conducted in the emergency department of Suzhou Hospital of Integrated Chinese and Western Medicine.
Participants: A total of 120 patients who underwent emergency transfusion treatment in our hospital from February 2021 to October 2022 were selected. They were divided into two groups, the control group, and the observation group, using a random number table method, with 60 patients in each group.
Interventions: The control group received standard nursing care, while the observation group received humanized nursing.
Primary outcome measures: The primary outcome measures included (1) assessment of psychological states, (2) evaluation of physical and mental comfort, (3) assessment of transfusion compliance, (4) incidence of adverse transfusion events, and (5) assessment of nursing satisfaction.
Results: Prior to nursing interventions, anxiety and depression scores were not significantly different between the two groups (P > .05). After nursing interventions, both groups exhibited a decrease in scores, with the observation group showing a more significant reduction compared to the control group (P < .05). In all aspects of physical and mental comfort, the observation group scored significantly higher than the control group (P < .05). Transfusion compliance and nursing satisfaction were significantly higher in the observation group compared to the control group (P < .01). The incidence of adverse transfusion events in the observation group was significantly lower than in the control group (P < .01).
Conclusions: Humanized nursing significantly improves anxiety and depression in emergency transfusion patients, enhances their physical and mental comfort, and increases transfusion compliance while reducing adverse transfusion events. It leads to high patient satisfaction with nursing services.
{"title":"The Impact of a Humanized Nursing Model on the Nursing Outcomes of Emergency Transfusion Patients.","authors":"Jinxia Chen, Dongsheng Ding","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Background: </strong>Emergency transfusion is a frequently performed invasive medical procedure. Patients often experience negative emotions and exhibit poor compliance during transfusion. Therefore, it is imperative to proactively implement effective nursing interventions.</p><p><strong>Objective: </strong>This study aims to investigate the impact of a humanized nursing model on the nursing outcomes of emergency transfusion patients.</p><p><strong>Design: </strong>This research was conducted as a randomized controlled experiment.</p><p><strong>Setting: </strong>The study was conducted in the emergency department of Suzhou Hospital of Integrated Chinese and Western Medicine.</p><p><strong>Participants: </strong>A total of 120 patients who underwent emergency transfusion treatment in our hospital from February 2021 to October 2022 were selected. They were divided into two groups, the control group, and the observation group, using a random number table method, with 60 patients in each group.</p><p><strong>Interventions: </strong>The control group received standard nursing care, while the observation group received humanized nursing.</p><p><strong>Primary outcome measures: </strong>The primary outcome measures included (1) assessment of psychological states, (2) evaluation of physical and mental comfort, (3) assessment of transfusion compliance, (4) incidence of adverse transfusion events, and (5) assessment of nursing satisfaction.</p><p><strong>Results: </strong>Prior to nursing interventions, anxiety and depression scores were not significantly different between the two groups (P > .05). After nursing interventions, both groups exhibited a decrease in scores, with the observation group showing a more significant reduction compared to the control group (P < .05). In all aspects of physical and mental comfort, the observation group scored significantly higher than the control group (P < .05). Transfusion compliance and nursing satisfaction were significantly higher in the observation group compared to the control group (P < .01). The incidence of adverse transfusion events in the observation group was significantly lower than in the control group (P < .01).</p><p><strong>Conclusions: </strong>Humanized nursing significantly improves anxiety and depression in emergency transfusion patients, enhances their physical and mental comfort, and increases transfusion compliance while reducing adverse transfusion events. It leads to high patient satisfaction with nursing services.</p>","PeriodicalId":7571,"journal":{"name":"Alternative therapies in health and medicine","volume":null,"pages":null},"PeriodicalIF":1.9,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136395819","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
<p><strong>Context: </strong>Intensive care units (ICUs) have the highest incidence of hospital-acquired infections. An in-depth understanding of the factors associated with PVIN infections may be the best way to prevent and control PVIN infections.</p><p><strong>Objective: </strong>The study aimed to investigate the factors associated with peripheral venous indwelling needle (PVIN) infections in older patients in the intensive care unit (ICU) and to use the findings to develop targeted preventive-care measures.</p><p><strong>Design: </strong>The research team conducted a prospective observational study of factors influencing PVIN infections and a prospective randomized controlled study of targeted nursing care.</p><p><strong>Setting: </strong>The studies took place at the First Affiliated Hospital, Nanjing Medical University, Nanjing, Jiangsu, China.</p><p><strong>Participants: </strong>For the first study, participants were 121 patients admitted to the hospital's ICU between April 2018 and June 2020, and for a second analysis, participants were 92 ICU patients admitted between December 2020 and March 2022. The first group took part in an analysis of the factors influencing PFIN infections and the second in a comparison of a targeted nursing intervention and routine care.</p><p><strong>Groups: </strong>For the first analysis, the research team divided the 121 participants into two groups: (1) a control group with 69 participants who didn't develop a PVIN infection and (2) an observation group with 52 participants who developed a PVIN infection. For the second analysis, the team randomly assigned the 92 participants to one of two groups: (1) 46 participants to a targeted nursing group who received care focused on preventing PVIN infections, and (2) 46 participants to a conventional group receiving routine care.</p><p><strong>Outcome measures: </strong>For the first analysis, the research team carried out logistic regression analysis to assess the factors related to PVIN infections, including the incidence of PVIN infections, durations of PVIN retention, ICU stays, and lengths of hospital stay (LOS). For the second analysis, the research team: (1) measured changes in blood glucose and inflammatory factor levels at baseline and postintervention and (2) conducted a nursing satisfaction survey upon patients' discharges.</p><p><strong>Results: </strong>For the first study, logistic multiple regression analysis revealed that the durations of catheter retention of ≥7d, a number of punctures ≥2 times, a duration of antibiotic administration of ≥14d, and Acute Physiology and Chronic Health Evaluation (APACHE II) scores were independent risk factors for PVIN infections in older patients in an ICU (all P < .001). After implementing targeted nursing strategies for the second study, the targeted care group had a significantly lower incidence of PVIN infections (P < .001), shorter duration of PVIN retention (P < .001), shorter ICU stay (P < .001), and shorter
{"title":"Factors Associated With Infections From Peripheral Venous Catheters in Older Patients in the ICU and Exploration of Preventive Measures.","authors":"Jun Yuan, Wenxia Bian, Qinna Hu, Changfang Chen","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Context: </strong>Intensive care units (ICUs) have the highest incidence of hospital-acquired infections. An in-depth understanding of the factors associated with PVIN infections may be the best way to prevent and control PVIN infections.</p><p><strong>Objective: </strong>The study aimed to investigate the factors associated with peripheral venous indwelling needle (PVIN) infections in older patients in the intensive care unit (ICU) and to use the findings to develop targeted preventive-care measures.</p><p><strong>Design: </strong>The research team conducted a prospective observational study of factors influencing PVIN infections and a prospective randomized controlled study of targeted nursing care.</p><p><strong>Setting: </strong>The studies took place at the First Affiliated Hospital, Nanjing Medical University, Nanjing, Jiangsu, China.</p><p><strong>Participants: </strong>For the first study, participants were 121 patients admitted to the hospital's ICU between April 2018 and June 2020, and for a second analysis, participants were 92 ICU patients admitted between December 2020 and March 2022. The first group took part in an analysis of the factors influencing PFIN infections and the second in a comparison of a targeted nursing intervention and routine care.</p><p><strong>Groups: </strong>For the first analysis, the research team divided the 121 participants into two groups: (1) a control group with 69 participants who didn't develop a PVIN infection and (2) an observation group with 52 participants who developed a PVIN infection. For the second analysis, the team randomly assigned the 92 participants to one of two groups: (1) 46 participants to a targeted nursing group who received care focused on preventing PVIN infections, and (2) 46 participants to a conventional group receiving routine care.</p><p><strong>Outcome measures: </strong>For the first analysis, the research team carried out logistic regression analysis to assess the factors related to PVIN infections, including the incidence of PVIN infections, durations of PVIN retention, ICU stays, and lengths of hospital stay (LOS). For the second analysis, the research team: (1) measured changes in blood glucose and inflammatory factor levels at baseline and postintervention and (2) conducted a nursing satisfaction survey upon patients' discharges.</p><p><strong>Results: </strong>For the first study, logistic multiple regression analysis revealed that the durations of catheter retention of ≥7d, a number of punctures ≥2 times, a duration of antibiotic administration of ≥14d, and Acute Physiology and Chronic Health Evaluation (APACHE II) scores were independent risk factors for PVIN infections in older patients in an ICU (all P < .001). After implementing targeted nursing strategies for the second study, the targeted care group had a significantly lower incidence of PVIN infections (P < .001), shorter duration of PVIN retention (P < .001), shorter ICU stay (P < .001), and shorter ","PeriodicalId":7571,"journal":{"name":"Alternative therapies in health and medicine","volume":null,"pages":null},"PeriodicalIF":1.9,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136395752","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Cerebral infarction, also known as ischemic stroke, is caused by various regional blood supply disorders in the brain tissue, leading to ischemic hypoxic lesions and necrosis of the brain tissue and then the corresponding clinical manifestations of neurological loss, which has high mortality and disability. This study comprehensively reviews the potential molecular mechanisms of TRPC6 in neuroprotection in cerebral infarction and provides a summary of TRPC6 as a targeted drug or prognostic biomarker for cerebral infarction patients. We will screen and synthesize evidence about the molecular mechanisms of TRPC6 in cerebral infarction from the current literature to obtain comprehensive knowledge on this topic. In the pathogenesis, neuroinflammation and intracellular calcium accumulation play an important role in the onset and development of cerebral infarction. Transient receptor potential cation channel subfamily C6 (TRPC6) is the main component of calcium store-operated calcium channels. It plays a central role in ischemic cerebrovascular disease by mediating the calcium ion signaling pathway. In this review, evidence on the neuroprotective effects of TRPC6 has been shown, including inhibiting neuroinflammation and inhibiting nerve cell apoptosis, thereby alleviating nerve injury. However, at the same time, TRPC6 promotes inflammation in other organs. Generally, although an increasing number of researches support the protective role of TRPC6 in cerebral infarction, there is still evidence showing that overexpression of TRPC6 increases inflammatory tissue damage in other organs. Therefore, clarifying the molecular mechanism of TRPC6 will help develop targeted drugs or prognostic biomarkers for cerebral infarction to promote and predict neurological function recovery. More evidence to elucidate the molecular mechanism of TRPC6 in cerebral infarction is needed. Enriching TRPC6 in neuroinflammation areas and modifying its cell specificity might be the orientation of drug development that increases the effect of stroke treatment and reduces the impact on other organs. In conclusion, in cerebral infarction, TRPC6 has been proven to alleviate neuroinflammation and inhibit nerve cell apoptosis. However, at the same time, TRPC6 may promote inflammation in other organs. Therefore, the targeting potential of TRPC6 in cerebral infarction needs to be further explored.
{"title":"Molecular Mechanism by Which TRPC6 Regulates Calcium Signaling and Neuroinflammation in the Onset and Development of Ischemic Stroke: A Review.","authors":"Wenbin Li, Yidan Zhang, Fan Yang, Lei Zhang","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Cerebral infarction, also known as ischemic stroke, is caused by various regional blood supply disorders in the brain tissue, leading to ischemic hypoxic lesions and necrosis of the brain tissue and then the corresponding clinical manifestations of neurological loss, which has high mortality and disability. This study comprehensively reviews the potential molecular mechanisms of TRPC6 in neuroprotection in cerebral infarction and provides a summary of TRPC6 as a targeted drug or prognostic biomarker for cerebral infarction patients. We will screen and synthesize evidence about the molecular mechanisms of TRPC6 in cerebral infarction from the current literature to obtain comprehensive knowledge on this topic. In the pathogenesis, neuroinflammation and intracellular calcium accumulation play an important role in the onset and development of cerebral infarction. Transient receptor potential cation channel subfamily C6 (TRPC6) is the main component of calcium store-operated calcium channels. It plays a central role in ischemic cerebrovascular disease by mediating the calcium ion signaling pathway. In this review, evidence on the neuroprotective effects of TRPC6 has been shown, including inhibiting neuroinflammation and inhibiting nerve cell apoptosis, thereby alleviating nerve injury. However, at the same time, TRPC6 promotes inflammation in other organs. Generally, although an increasing number of researches support the protective role of TRPC6 in cerebral infarction, there is still evidence showing that overexpression of TRPC6 increases inflammatory tissue damage in other organs. Therefore, clarifying the molecular mechanism of TRPC6 will help develop targeted drugs or prognostic biomarkers for cerebral infarction to promote and predict neurological function recovery. More evidence to elucidate the molecular mechanism of TRPC6 in cerebral infarction is needed. Enriching TRPC6 in neuroinflammation areas and modifying its cell specificity might be the orientation of drug development that increases the effect of stroke treatment and reduces the impact on other organs. In conclusion, in cerebral infarction, TRPC6 has been proven to alleviate neuroinflammation and inhibit nerve cell apoptosis. However, at the same time, TRPC6 may promote inflammation in other organs. Therefore, the targeting potential of TRPC6 in cerebral infarction needs to be further explored.</p>","PeriodicalId":7571,"journal":{"name":"Alternative therapies in health and medicine","volume":null,"pages":null},"PeriodicalIF":1.9,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136395810","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Objective: The objective of this study is to evaluate the effectiveness of targeted nursing measures in relieving swollen limb pain after extremity fractures. The term "targeted nursing measures" refers to specific nursing interventions and care strategies that are designed to address the issue of swollen limb pain in patients with extremity fractures.
Methods: Patients with extremity fractures treated in our hospital between January 2020 and December 2021 were recruited for eligibility assessment, and 100 patients were eventually included and assigned alternately at the time of admission to receive routine care, namely standard nursing interventions commonly provided to individuals with extremity fractures (These interventions included preoperative assessment, vital sign monitoring, postoperative status monitoring, local ice application, elevation of the affected limb, functional exercise, pain relief measures, postoperative nutrition, medication administration, and general health instruction) (routine group) or targeted care, namely care measures tailored to address swollen limb pain. (These targeted care measures included health education regarding the causes of limb fractures, precautions, causes of swollen limb pain after fractures, and treatment methods, decongestion care, ice compresses to promote vasoconstriction and reduce pain and swelling, psychological counseling to relieve negative emotions, and targeted rehabilitation training supervision) (targeted group), with 50 patients in each group. Outcome measures included swelling, pain, emotional state, and nursing satisfaction.
Results: Targeted care resulted in better mitigation of swelling versus routine care (P < .05). Patients with targeted care had significantly lower visual analog scale (VAS) scores, self-rating anxiety scale (SAS) scores, and Hamilton depression scale (HAMD) scores, and higher Connor-Davidson resilience scale (CD-RISC) scores versus those with routine care (P < .05). Targeted care was associated with significantly higher nursing satisfaction versus routine care (P < .05).
Conclusion: Targeted care rapidly relieves the degree of swelling and pain of patients with extremity fractures and ameliorates their emotional state, thereby promoting health recovery and effectively improving patient satisfaction.
{"title":"Effectiveness of Targeted Nursing Measures to Relieve Swollen Limb Pain after Extremity Fracture.","authors":"Xueping Wang, Hui Xu, Xuyi Wu","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Objective: </strong>The objective of this study is to evaluate the effectiveness of targeted nursing measures in relieving swollen limb pain after extremity fractures. The term \"targeted nursing measures\" refers to specific nursing interventions and care strategies that are designed to address the issue of swollen limb pain in patients with extremity fractures.</p><p><strong>Methods: </strong>Patients with extremity fractures treated in our hospital between January 2020 and December 2021 were recruited for eligibility assessment, and 100 patients were eventually included and assigned alternately at the time of admission to receive routine care, namely standard nursing interventions commonly provided to individuals with extremity fractures (These interventions included preoperative assessment, vital sign monitoring, postoperative status monitoring, local ice application, elevation of the affected limb, functional exercise, pain relief measures, postoperative nutrition, medication administration, and general health instruction) (routine group) or targeted care, namely care measures tailored to address swollen limb pain. (These targeted care measures included health education regarding the causes of limb fractures, precautions, causes of swollen limb pain after fractures, and treatment methods, decongestion care, ice compresses to promote vasoconstriction and reduce pain and swelling, psychological counseling to relieve negative emotions, and targeted rehabilitation training supervision) (targeted group), with 50 patients in each group. Outcome measures included swelling, pain, emotional state, and nursing satisfaction.</p><p><strong>Results: </strong>Targeted care resulted in better mitigation of swelling versus routine care (P < .05). Patients with targeted care had significantly lower visual analog scale (VAS) scores, self-rating anxiety scale (SAS) scores, and Hamilton depression scale (HAMD) scores, and higher Connor-Davidson resilience scale (CD-RISC) scores versus those with routine care (P < .05). Targeted care was associated with significantly higher nursing satisfaction versus routine care (P < .05).</p><p><strong>Conclusion: </strong>Targeted care rapidly relieves the degree of swelling and pain of patients with extremity fractures and ameliorates their emotional state, thereby promoting health recovery and effectively improving patient satisfaction.</p>","PeriodicalId":7571,"journal":{"name":"Alternative therapies in health and medicine","volume":null,"pages":null},"PeriodicalIF":1.9,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141246944","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Objective: This study investigated the role of titanium clip marking during endoscopy in managing patients with upper gastrointestinal bleeding (UGIB) for whom endoscopic hemostasis has proven ineffective.
Methods: A total of 63 UGIB patients admitted to the Affiliated Hospital of Zunyi Medical University between January 2018 and November 2020 were selected as the study cohort. Patients were randomly assigned to one of two groups: the control group (n=23) and the combined group (n=40). The control group underwent transcatheter arterial embolization (TAE), while the combined group received endoscopic metallic titanium clip-assisted TAE. This study compared the rates of successful embolization, clinical success, recurrence, operation time, radiation exposure time, radiation dosage, levels of hs-CRP, Cor, NE, TNF-α, IL-6, and ADH before and after treatment, as well as postoperative complications between the two groups.
Results: The combined group of patients exhibited significantly higher rates of successful embolization and clinical success compared to the control group (P < .05). Additionally, the recurrence rate and levels of hs-CRP, Cor, NE, TNF-α, IL-6, and ADH were significantly lower in the combined group compared to the control group (P < .05). Furthermore, patients in the combined group had shorter operation times, reduced radiation exposure times, and lower radiation dosages compared to the control group (P < .05). There was no statistically significant difference in the occurrence of postoperative complications between the two groups (P > .05).
Conclusions: Using titanium clip marking during endoscopy provides valuable guidance in managing patients with upper gastrointestinal bleeding who have not responded to endoscopic hemostasis. This finding is especially relevant in digital subtraction angiography (DSA) and transcatheter arterial embolization (TAE) treatments. It enhances the clinical efficacy and safety of the procedure.
{"title":"Evaluating the Significance of Titanium Clip Marking Under Endoscopy in Upper Gastrointestinal Bleeding Patients with Failed Endoscopic Hemostasis.","authors":"Jin Zhu, Rongshu Shi, Bangguo Li, Kongwu Yang","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Objective: </strong>This study investigated the role of titanium clip marking during endoscopy in managing patients with upper gastrointestinal bleeding (UGIB) for whom endoscopic hemostasis has proven ineffective.</p><p><strong>Methods: </strong>A total of 63 UGIB patients admitted to the Affiliated Hospital of Zunyi Medical University between January 2018 and November 2020 were selected as the study cohort. Patients were randomly assigned to one of two groups: the control group (n=23) and the combined group (n=40). The control group underwent transcatheter arterial embolization (TAE), while the combined group received endoscopic metallic titanium clip-assisted TAE. This study compared the rates of successful embolization, clinical success, recurrence, operation time, radiation exposure time, radiation dosage, levels of hs-CRP, Cor, NE, TNF-α, IL-6, and ADH before and after treatment, as well as postoperative complications between the two groups.</p><p><strong>Results: </strong>The combined group of patients exhibited significantly higher rates of successful embolization and clinical success compared to the control group (P < .05). Additionally, the recurrence rate and levels of hs-CRP, Cor, NE, TNF-α, IL-6, and ADH were significantly lower in the combined group compared to the control group (P < .05). Furthermore, patients in the combined group had shorter operation times, reduced radiation exposure times, and lower radiation dosages compared to the control group (P < .05). There was no statistically significant difference in the occurrence of postoperative complications between the two groups (P > .05).</p><p><strong>Conclusions: </strong>Using titanium clip marking during endoscopy provides valuable guidance in managing patients with upper gastrointestinal bleeding who have not responded to endoscopic hemostasis. This finding is especially relevant in digital subtraction angiography (DSA) and transcatheter arterial embolization (TAE) treatments. It enhances the clinical efficacy and safety of the procedure.</p>","PeriodicalId":7571,"journal":{"name":"Alternative therapies in health and medicine","volume":null,"pages":null},"PeriodicalIF":1.9,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72013098","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Objective: This study aimed to analyze the impact of nutritional intervention during radiotherapy for head and neck tumors and its effects on energy intake, consumption, and nutritional status.
Methods: A comparative or observational study was conducted, and a total of 103 head and neck tumor patients undergoing radiotherapy were selected for this study and divided into two groups. The control group (n = 51) received routine nursing intervention, while the observation group (n = 52) received additional nutritional intervention. We compared the nutritional status, energy intake and consumption, and emotional well-being between the two groups.
Results: After the intervention, the observation group exhibited significantly higher levels of BMI, serum prealbumin, hemoglobin, and albumin compared to the control group (P < .05). Energy intake during radiotherapy was significantly higher in the observation group than in the control group. Furthermore, the energy consumption in the observation group was significantly lower than in the control group (P < .05). After the intervention, the observation group reported lower scores on the Self-rating Anxiety Scale and Self-rating Depression Scale compared to the control group (P < .05). In a three-month follow-up after radiotherapy, the observation group's EORTC Cancer Quality of Life Scale score was also significantly higher than that of the control group (P < .05).
Conclusions: Nutritional intervention proved effective in increasing energy intake and reducing energy consumption in patients undergoing radiotherapy for head and neck tumors. This improvement positively impacted the nutritional status and quality of life of the patients, emphasizing its significant research value.
{"title":"Effect of Nutritional Intervention on Energy Intake in Head and Neck Cancer Patients After Radiotherapy.","authors":"Yuanyuan Li, Yingtao Meng, Zengfen Pang, Jing Huai, Suisui Yi, Ronghua Kong","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Objective: </strong>This study aimed to analyze the impact of nutritional intervention during radiotherapy for head and neck tumors and its effects on energy intake, consumption, and nutritional status.</p><p><strong>Methods: </strong>A comparative or observational study was conducted, and a total of 103 head and neck tumor patients undergoing radiotherapy were selected for this study and divided into two groups. The control group (n = 51) received routine nursing intervention, while the observation group (n = 52) received additional nutritional intervention. We compared the nutritional status, energy intake and consumption, and emotional well-being between the two groups.</p><p><strong>Results: </strong>After the intervention, the observation group exhibited significantly higher levels of BMI, serum prealbumin, hemoglobin, and albumin compared to the control group (P < .05). Energy intake during radiotherapy was significantly higher in the observation group than in the control group. Furthermore, the energy consumption in the observation group was significantly lower than in the control group (P < .05). After the intervention, the observation group reported lower scores on the Self-rating Anxiety Scale and Self-rating Depression Scale compared to the control group (P < .05). In a three-month follow-up after radiotherapy, the observation group's EORTC Cancer Quality of Life Scale score was also significantly higher than that of the control group (P < .05).</p><p><strong>Conclusions: </strong>Nutritional intervention proved effective in increasing energy intake and reducing energy consumption in patients undergoing radiotherapy for head and neck tumors. This improvement positively impacted the nutritional status and quality of life of the patients, emphasizing its significant research value.</p>","PeriodicalId":7571,"journal":{"name":"Alternative therapies in health and medicine","volume":null,"pages":null},"PeriodicalIF":1.9,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138796007","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Objective: A new aldehyde-free fixative has been developed and its effect has been compared to traditional formaldehyde fixative in terms of the fixation effect and HE staining of the heart, liver, lung, and kidney. The air in the experimental area was examined to evaluate its impact on the environment and human health.
Methods: The organs from mice of groups 1-6 were taken respectively (thickness of liver and lung was 3 mm). After the heart and kidney capsule were removed, the organs were longitudinally cut along their maximum surface, and half was taken. Thereafter, the tissue fixation effect was observed by Hematein and Eosin (H＆E) staining and the total protein content of tissue was examined by the ultramicro spectrophotometer. Additionally, the volatility ratio of the new fixative and the traditional formaldehyde is compared.
Result: The results showed that there was no significant difference between the fixation effect of the new aldehyde-free fixation and the traditional formaldehyde fixative on mouse organs and the air quality in the experimental area was found to be significantly better when the new aldehyde-free fixative is used than when the traditional formaldehyde fixative is used.
Conclusion: Traditional formaldehyde fixative in HE staining can be replaced by the new environment-friendly formaldehyde-free fixative, however further special staining of fixed tissue and immunohistochemical studies are needed.
{"title":"Evaluation of a Novel Formaldehyde-Free Fixation Solution for the Fixation of Mouse Organs.","authors":"Huiqiu Zhang, Rongquan Huang, Huyu Zhang, Zhiyan Gao","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Objective: </strong>A new aldehyde-free fixative has been developed and its effect has been compared to traditional formaldehyde fixative in terms of the fixation effect and HE staining of the heart, liver, lung, and kidney. The air in the experimental area was examined to evaluate its impact on the environment and human health.</p><p><strong>Methods: </strong>The organs from mice of groups 1-6 were taken respectively (thickness of liver and lung was 3 mm). After the heart and kidney capsule were removed, the organs were longitudinally cut along their maximum surface, and half was taken. Thereafter, the tissue fixation effect was observed by Hematein and Eosin (H＆E) staining and the total protein content of tissue was examined by the ultramicro spectrophotometer. Additionally, the volatility ratio of the new fixative and the traditional formaldehyde is compared.</p><p><strong>Result: </strong>The results showed that there was no significant difference between the fixation effect of the new aldehyde-free fixation and the traditional formaldehyde fixative on mouse organs and the air quality in the experimental area was found to be significantly better when the new aldehyde-free fixative is used than when the traditional formaldehyde fixative is used.</p><p><strong>Conclusion: </strong>Traditional formaldehyde fixative in HE staining can be replaced by the new environment-friendly formaldehyde-free fixative, however further special staining of fixed tissue and immunohistochemical studies are needed.</p>","PeriodicalId":7571,"journal":{"name":"Alternative therapies in health and medicine","volume":null,"pages":null},"PeriodicalIF":1.9,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138796068","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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