Pub Date : 2025-03-01Epub Date: 2024-10-18DOI: 10.1016/j.ajog.2024.10.018
Neil Gupta, Lindsey Hiebert, John W Ward
{"title":"Key actions to improve linkage to care for pregnant and postpartum women with hepatitis C.","authors":"Neil Gupta, Lindsey Hiebert, John W Ward","doi":"10.1016/j.ajog.2024.10.018","DOIUrl":"10.1016/j.ajog.2024.10.018","url":null,"abstract":"","PeriodicalId":7574,"journal":{"name":"American journal of obstetrics and gynecology","volume":" ","pages":"e120"},"PeriodicalIF":8.7,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142455866","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-03-01Epub Date: 2024-10-19DOI: 10.1016/j.ajog.2024.10.012
Carry Verberkt, Sanne I Stegwee, Judith A F Huirne
{"title":"Should we focus on endometrial-free closure technique?","authors":"Carry Verberkt, Sanne I Stegwee, Judith A F Huirne","doi":"10.1016/j.ajog.2024.10.012","DOIUrl":"10.1016/j.ajog.2024.10.012","url":null,"abstract":"","PeriodicalId":7574,"journal":{"name":"American journal of obstetrics and gynecology","volume":" ","pages":"e109-e110"},"PeriodicalIF":8.7,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142455868","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-03-01Epub Date: 2024-10-18DOI: 10.1016/j.ajog.2024.10.015
Supreet K Raina, Keisha Callins
{"title":"Commentary on distinct obstetrical characteristics and maternal mortality in patients with HELLP syndrome vs severe preeclampsia.","authors":"Supreet K Raina, Keisha Callins","doi":"10.1016/j.ajog.2024.10.015","DOIUrl":"10.1016/j.ajog.2024.10.015","url":null,"abstract":"","PeriodicalId":7574,"journal":{"name":"American journal of obstetrics and gynecology","volume":" ","pages":"e117"},"PeriodicalIF":8.7,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142455862","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-02-25DOI: 10.1016/j.ajog.2025.02.036
Daniel J Kiely
{"title":"Optimizing patient selection and technique for occiput posterior vacuum extraction.","authors":"Daniel J Kiely","doi":"10.1016/j.ajog.2025.02.036","DOIUrl":"https://doi.org/10.1016/j.ajog.2025.02.036","url":null,"abstract":"","PeriodicalId":7574,"journal":{"name":"American journal of obstetrics and gynecology","volume":" ","pages":""},"PeriodicalIF":8.7,"publicationDate":"2025-02-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143522400","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-02-20DOI: 10.1016/S0002-9378(25)00035-3
{"title":"Information for readers","authors":"","doi":"10.1016/S0002-9378(25)00035-3","DOIUrl":"10.1016/S0002-9378(25)00035-3","url":null,"abstract":"","PeriodicalId":7574,"journal":{"name":"American journal of obstetrics and gynecology","volume":"232 3","pages":"Page A7"},"PeriodicalIF":8.7,"publicationDate":"2025-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143454895","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-02-20DOI: 10.1016/S0002-9378(25)00037-7
{"title":"AJOG GR Table of Contents","authors":"","doi":"10.1016/S0002-9378(25)00037-7","DOIUrl":"10.1016/S0002-9378(25)00037-7","url":null,"abstract":"","PeriodicalId":7574,"journal":{"name":"American journal of obstetrics and gynecology","volume":"232 3","pages":"Page A10"},"PeriodicalIF":8.7,"publicationDate":"2025-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143454897","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-02-20DOI: 10.1016/j.ajog.2025.02.033
Hanxi Zheng, Meng Liu, Qiaolian Su, Hong Li, Fuxin Wang
<p><strong>Background: </strong>Adenomyosis is a uterine disorder closely linked to infertility and adverse pregnancy outcomes. Despite its clinical significance, the mechanisms by which adenomyosis impairs embryo implantation and perinatal outcomes remain incompletely defined. Previous studies have indicated that alterations in the uterine microenvironment may contribute to these reproductive challenges.</p><p><strong>Aim: </strong>To investigate the effects of adenomyosis on fertility and perinatal outcomes using a novel murine model and to identify molecular pathways involved in implantation failure and pregnancy loss.</p><p><strong>Study design: </strong>A mechanically induced adenomyosis model was established in female BALB/c mice through endometrial-myometrial interface disruption (EMID) to closely simulate the clinical condition observed in humans. Mice were randomly assigned to either the adenomyosis group or a sham-operated control group. Reproductive outcomes were systematically assessed at multiple gestational time points, focusing on embryo implantation site distribution, implantation rates, pregnancy loss, fetal growth parameters, and postnatal uterine recovery. In parallel, uterine tissues collected from implantation sites and inter-implantation regions at 4.5 days post coitus were subjected to RNA sequencing. Differential gene expression analyses were performed, and enriched pathways were identified using Gene Ontology and KEGG enrichment tools.</p><p><strong>Results: </strong>Mice in the adenomyosis group demonstrated significant disruptions in the uterine microenvironment compared to controls. Notably, the adenomyosis group exhibited irregular distribution of implantation sites with reduced inter-embryo distances, leading to compromised spatial organization of the developing conceptuses. Although the total number of embryos at early gestation did not differ significantly between groups, a marked increase in pregnancy loss was observed during mid-gestation, accompanied by a reduction in the size of surviving embryos. Histological evaluation revealed extensive architectural disruptions in the uterine muscle layers and increased local inflammatory responses in adenomyotic uteri. RNA sequencing further revealed that adenomyosis was associated with the dysregulation of multiple genes involved in immune modulation, apoptotic regulation, and metabolic processes. In particular, significant enrichment of the PI3K-Akt, MAPK, and TNF signaling pathways was observed, suggesting that variation in these cascades may underlie the impaired uterine receptivity and embryo development seen in adenomyosis.</p><p><strong>Conclusion: </strong>Our findings indicate that adenomyosis exerts a adverse effect on fertility and perinatal outcomes by disrupting the uterine environment and interfering with critical molecular pathways essential for proper embryo implantation and development. The results of this study not only enhance our understanding of adenom
{"title":"Impaired Fertility and Perinatal Outcomes in Adenomyosis: Insights from a Novel Murine Model and Uterine Gene Profile Alterations During Implantations.","authors":"Hanxi Zheng, Meng Liu, Qiaolian Su, Hong Li, Fuxin Wang","doi":"10.1016/j.ajog.2025.02.033","DOIUrl":"https://doi.org/10.1016/j.ajog.2025.02.033","url":null,"abstract":"<p><strong>Background: </strong>Adenomyosis is a uterine disorder closely linked to infertility and adverse pregnancy outcomes. Despite its clinical significance, the mechanisms by which adenomyosis impairs embryo implantation and perinatal outcomes remain incompletely defined. Previous studies have indicated that alterations in the uterine microenvironment may contribute to these reproductive challenges.</p><p><strong>Aim: </strong>To investigate the effects of adenomyosis on fertility and perinatal outcomes using a novel murine model and to identify molecular pathways involved in implantation failure and pregnancy loss.</p><p><strong>Study design: </strong>A mechanically induced adenomyosis model was established in female BALB/c mice through endometrial-myometrial interface disruption (EMID) to closely simulate the clinical condition observed in humans. Mice were randomly assigned to either the adenomyosis group or a sham-operated control group. Reproductive outcomes were systematically assessed at multiple gestational time points, focusing on embryo implantation site distribution, implantation rates, pregnancy loss, fetal growth parameters, and postnatal uterine recovery. In parallel, uterine tissues collected from implantation sites and inter-implantation regions at 4.5 days post coitus were subjected to RNA sequencing. Differential gene expression analyses were performed, and enriched pathways were identified using Gene Ontology and KEGG enrichment tools.</p><p><strong>Results: </strong>Mice in the adenomyosis group demonstrated significant disruptions in the uterine microenvironment compared to controls. Notably, the adenomyosis group exhibited irregular distribution of implantation sites with reduced inter-embryo distances, leading to compromised spatial organization of the developing conceptuses. Although the total number of embryos at early gestation did not differ significantly between groups, a marked increase in pregnancy loss was observed during mid-gestation, accompanied by a reduction in the size of surviving embryos. Histological evaluation revealed extensive architectural disruptions in the uterine muscle layers and increased local inflammatory responses in adenomyotic uteri. RNA sequencing further revealed that adenomyosis was associated with the dysregulation of multiple genes involved in immune modulation, apoptotic regulation, and metabolic processes. In particular, significant enrichment of the PI3K-Akt, MAPK, and TNF signaling pathways was observed, suggesting that variation in these cascades may underlie the impaired uterine receptivity and embryo development seen in adenomyosis.</p><p><strong>Conclusion: </strong>Our findings indicate that adenomyosis exerts a adverse effect on fertility and perinatal outcomes by disrupting the uterine environment and interfering with critical molecular pathways essential for proper embryo implantation and development. The results of this study not only enhance our understanding of adenom","PeriodicalId":7574,"journal":{"name":"American journal of obstetrics and gynecology","volume":" ","pages":""},"PeriodicalIF":8.7,"publicationDate":"2025-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143476102","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-02-20DOI: 10.1016/S0002-9378(25)00036-5
{"title":"AJOG MFM Table of Contents","authors":"","doi":"10.1016/S0002-9378(25)00036-5","DOIUrl":"10.1016/S0002-9378(25)00036-5","url":null,"abstract":"","PeriodicalId":7574,"journal":{"name":"American journal of obstetrics and gynecology","volume":"232 3","pages":"Page A9"},"PeriodicalIF":8.7,"publicationDate":"2025-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143454896","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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