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Vaginal microbiota in late pregnancy associates with the outcomes of planned induced labor: a multicenter prospective cohort study 妊娠后期阴道微生物群与计划引产结局相关:一项多中心前瞻性队列研究
IF 9.8 1区 医学 Q1 OBSTETRICS & GYNECOLOGY Pub Date : 2026-01-28 DOI: 10.1016/j.ajog.2026.01.026
Shiman Hu, Xiuchao Wang, Hongbin Xu, Jiali Xiong, Ying Gu, Xiaohui Cao, Liping Zhou, Yuru Fan, Shanshan Wang, Xueqi Bai, Haoyan Shi, Qingyi Zhu, Lianmin Chen, Zhonghua Shi
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引用次数: 0
Maternal body mass index and neonatal morbidity with shoulder dystocia (Letter-to-the-Editor) 产妇体重指数与新生儿肩难产发病率(致编辑信)
IF 9.8 1区 医学 Q1 OBSTETRICS & GYNECOLOGY Pub Date : 2026-01-27 DOI: 10.1016/j.ajog.2026.01.024
Chelsey Green, Lauren Milam, Jennifer R. Bail
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引用次数: 0
Prepregnancy maternal body mass index and shoulder dystocia (Reply to Letter-to-the-Editor) 孕前孕妇体重指数与肩难产(回复编辑信)
IF 9.8 1区 医学 Q1 OBSTETRICS & GYNECOLOGY Pub Date : 2026-01-27 DOI: 10.1016/j.ajog.2026.01.023
Aneesha Cheedalla, Jennifer L. Grasch, Heather A. Frey
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引用次数: 0
Evidence of brain injury in fetuses of mothers with preterm labor with intact membranes and preterm premature rupture of membranes (Letter-to-the-Editor) 胎膜完整和胎膜早破的早产母亲胎儿脑损伤的证据(致编辑的信)
IF 9.8 1区 医学 Q1 OBSTETRICS & GYNECOLOGY Pub Date : 2026-01-24 DOI: 10.1016/j.ajog.2026.01.025
Federica Fernicola, Sara Ornaghi, Anna Locatelli
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引用次数: 0
FAMILY PLANNING AND MATERNAL MORTALITY 计划生育和产妇死亡率
IF 9.8 1区 医学 Q1 OBSTETRICS & GYNECOLOGY Pub Date : 2026-01-23 DOI: 10.1016/j.ajog.2026.01.019
Lucia LI, Jeffrey F. PEIPERT
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引用次数: 0
Endometriosis and early pregnancy outcomes: a registry-based cohort study in Finland. 子宫内膜异位症和早期妊娠结局:芬兰一项基于登记的队列研究。
IF 9.8 1区 医学 Q1 OBSTETRICS & GYNECOLOGY Pub Date : 2026-01-23 DOI: 10.1016/j.ajog.2026.01.027
J Megan Gurney,Anni Tuominen,Juuso Saavalainen,Mika Gissler,Maarit Niinimäki,Oskari Heikinheimo,Liisu Saavalainen
BACKGROUNDUnderstanding of the impact of endometriosis on adverse early pregnancy outcomes has evolved in recent decades and has been partly attributed to endocrine dysfunction and chronic inflammation. However, data from population-based cohort studies which include all pregnancy outcomes, with long-term follow-up, are lacking.OBJECTIVEThis longitudinal cohort study aimed to investigate the association between endometriosis and early pregnancy outcomes including miscarriage, ectopic pregnancy, induced abortion, and molar pregnancy.STUDY DESIGNWe conducted a retrospective registry study including all 10,105 people in Finland born after 1972 with a first surgical diagnosis of endometriosis between 1998 and 2012 in the Finnish Care Register for Health Care. We also included 19,526 age- and residence-matched individuals. We collected all registered pregnancies of the study cohorts-both prior to and following surgical diagnosis of endometriosis-from Finnish registries from age 15 until the occurrence of sterilization, bilateral oophorectomy, sequential unilateral oophorectomies, hysterectomy, death, emigration, or the end of the study period, whichever occurred first. We calculated the cumulative incidence and incidence rate of pregnancy. For the specific pregnancy outcomes, we calculated their proportions, risk per 100 pregnancies, and risk ratios (RR) adjusting for age, gravidity, and education level. In the endometriosis cohort, there was 256,906 person-years of follow-up and in the reference cohort, 503,286 person-years.RESULTSWe identified 19,141 pregnancies in 7731 (76.5%) ever-pregnant participants with endometriosis and 43,478 pregnancies in 15,421 (79.0%) ever-pregnant reference participants during a median follow-up time of 26.4 years (interquartile range, 22.5-29.6). The mean number of registry-identified pregnancies per person in the endometriosis cohort was 1.89 (standard deviation, 1.64), compared to 2.23 (1.92) in the reference cohort (p < .001). Of the pregnancies with known outcomes-that is, excluding pregnancies which were ongoing at the end of the study period-72.0% vs 75.7% were births (p <.001), 15.6% vs 10.4% were miscarriages (p <.001), 3.5% vs 1.5% were ectopic pregnancies (p <.001), 8.8% vs 12.3% were induced abortions (p < .001), and 0.1% vs 0.1% were molar pregnancies (p = .99) in the endometriosis and in the reference cohorts, respectively. Individuals with endometriosis had lower pregnancy rates compared to the reference cohort, with an IRR of 0.87 (95% confidence interval, 0.86-0.89) when adjusted for education level and birth year. Conversely, they experienced significantly higher age-adjusted risks of miscarriage (aRR 1.51; 1.43-1.60) and ectopic pregnancy (2.45; 2.21-2.71). The risk of induced abortion was lower in those with endometriosis (aRR 0.69; 0.65-0.74), and there was no significant difference in the risk of molar pregnancy.CONCLUSIONSIndividuals with surgically verified endometriosis had a lower lifetime inci
近几十年来,人们对子宫内膜异位症对妊娠早期不良结局的影响的理解不断发展,部分原因是内分泌功能障碍和慢性炎症。然而,缺乏包括所有妊娠结局和长期随访的基于人群的队列研究的数据。目的:本纵向队列研究旨在探讨子宫内膜异位症与早期妊娠结局(包括流产、异位妊娠、人工流产和磨牙妊娠)的关系。研究设计:我们进行了一项回顾性登记研究,包括芬兰所有10,105名1972年以后出生、1998年至2012年间首次手术诊断为子宫内膜异位症的芬兰人。我们还包括19,526名年龄和居住地匹配的个体。我们从芬兰的登记处收集了研究队列中所有登记的妊娠,包括手术诊断子宫内膜异位症之前和之后的妊娠,从15岁到绝育、双侧卵巢切除术、连续单侧卵巢切除术、子宫切除术、死亡、移民或研究期结束,以先发生者为准。我们计算了累积发病率和妊娠发生率。对于特定的妊娠结局,我们计算了它们的比例,每100次妊娠的风险,以及调整年龄、妊娠和教育水平的风险比(RR)。在子宫内膜异位症队列中,随访人数为256,906人/年,而在参考队列中,随访人数为503,286人/年。结果在中位26.4年的随访期间(四分位数范围22.5-29.6),我们在7731名(76.5%)子宫内膜异位症患者中发现了19141例妊娠,在15421名(79.0%)曾经怀孕的参考参与者中发现了43478例妊娠。子宫内膜异位症队列中登记确认的人均怀孕数平均为1.89(标准差,1.64),而参考队列中为2.23 (1.92)(p < 0.001)。在已知结局的妊娠中,即排除研究结束时正在进行的妊娠,子宫内膜异位症和参考队列中分别有72.0%对75.7%为出生(p < 0.001), 15.6%对10.4%为流产(p < 0.001), 3.5%对1.5%为异位妊娠(p < 0.001), 8.8%对12.3%为人工流产(p < 0.001), 0.1%对0.1%为磨牙妊娠(p = 0.99)。与参考队列相比,子宫内膜异位症患者的妊娠率较低,经教育水平和出生年份调整后的IRR为0.87(95%可信区间,0.86-0.89)。相反,他们经历了明显更高的年龄调整风险流产(aRR 1.51; 1.43-1.60)和异位妊娠(aRR 2.45; 2.21-2.71)。子宫内膜异位症的人工流产风险较低(aRR 0.69; 0.65-0.74),磨牙妊娠的风险无显著差异。结论手术证实子宫内膜异位症患者的终生妊娠发生率低于无子宫内膜异位症患者。在子宫内膜异位症患者的怀孕中,分娩和人工流产较少,但由于流产和异位妊娠的比例增加,早期妊娠丢失的风险较高。
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引用次数: 0
Adult-Onset Cutaneous Mastocytosis Presenting as Vulvar Papules 成人发病的皮肤肥大细胞增多症表现为外阴丘疹
IF 9.8 1区 医学 Q1 OBSTETRICS & GYNECOLOGY Pub Date : 2026-01-23 DOI: 10.1016/j.ajog.2026.01.020
Natalie Braun, Alvaro C. Laga Canales, Susan Burgin
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引用次数: 0
Florid Cystic Endosalpingiosis: Recognizing a Rare, Benign Entity in Uterine Pathology 绚丽囊性输卵管内肿大:认识子宫病理中一种罕见的良性实体
IF 9.8 1区 医学 Q1 OBSTETRICS & GYNECOLOGY Pub Date : 2026-01-23 DOI: 10.1016/j.ajog.2026.01.021
Fleur Mak, Nerlyne Desravines, M.Yvette Williams-Brown, Nida Safdar
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引用次数: 0
Requiring general oral examinations for subspecialists (Letter-to-the-Editor) 要求分专科医生进行一般口试(致编者信)
IF 9.8 1区 医学 Q1 OBSTETRICS & GYNECOLOGY Pub Date : 2026-01-22 DOI: 10.1016/j.ajog.2026.01.018
Jose “Tony” Carugno
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引用次数: 0
3-Dimensional ultrasound imaging to delineate focal lesions of placenta accreta spectrum 三维超声成像描绘增生性胎盘局灶性病变频谱
IF 9.8 1区 医学 Q1 OBSTETRICS & GYNECOLOGY Pub Date : 2026-01-20 DOI: 10.1016/j.ajog.2026.01.016
Savitree Pranpanus, Christoph C. Lees
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引用次数: 0
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American journal of obstetrics and gynecology
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