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Current topics in molecular endocrinology最新文献

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Adrenal steroids, membranes and neoplasia. 肾上腺类固醇，膜和肿瘤。
Current topics in molecular endocrinology
Pub Date : 1976-01-01 DOI: 10.1007/978-1-4684-2601-4_11
T D Gelehrter
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引用次数: 6
The cellular actions of glucocorticoids in relation to human neoplasms. 糖皮质激素在人类肿瘤中的细胞作用。
Current topics in molecular endocrinology
Pub Date : 1976-01-01 DOI: 10.1007/978-1-4684-2601-4_10
E B Thompson
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引用次数: 9
Selecting endocrine therapy in breast cancer. 乳腺癌内分泌治疗的选择。
Current topics in molecular endocrinology
Pub Date : 1976-01-01 DOI: 10.1007/978-1-4684-2601-4_3
W L McGuire, K B Horwitz, M De La Garza
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引用次数: 63
Clinical implications of growth hormone release inhibiting hormone (GH-RIH). 生长激素释放抑制激素(GH-RIH)的临床意义。
Current topics in molecular endocrinology
Pub Date : 1976-01-01 DOI: 10.1007/978-1-4684-2598-7_8
G M Besser
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引用次数: 5
Immunohistochemical localization of hypothalamic hormones at the electron microscope level. 电镜下下丘脑激素的免疫组织化学定位。
Current topics in molecular endocrinology
Pub Date : 1976-01-01 DOI: 10.1007/978-1-4684-2598-7_24
G Pelletier
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引用次数: 6
Somatostatin and the endocrine pancreas. 生长抑素和胰腺内分泌。
Current topics in molecular endocrinology
Pub Date : 1976-01-01 DOI: 10.1007/978-1-4684-2598-7_9
J E Gerich

Thus far, somatostatin has been used primarily as a research tool to investigate pancreatic alpha- and beta- cell function. On the basis of its ability to inhibit insulin and glucagon secretion, several therapeutic applications have been suggested: e.g., as an adjunct in the treatment of diabetes mellitus, or as a palliative agent in inoperable islet tumors. Current experiments are underway to develop more specific analogs with longer durations of action to permit clinical evaluation of these potential applications. The presence of somatostatin within the pancreatic D cells raises the possibility that it may function as a local regulator of insulin and glucagon release. Clearly, further work is needed to delineate the factors governing the secretion of somatostatin and its mode of action. Such studies may uncover a new class of syndromes resulting from D-cell dysfunction.

到目前为止，生长抑素主要被用作研究胰腺α和β细胞功能的研究工具。基于其抑制胰岛素和胰高血糖素分泌的能力，已经提出了几种治疗应用:例如，作为糖尿病治疗的辅助药物，或作为不能手术的胰岛肿瘤的姑息剂。目前的实验正在进行中，以开发具有更长的作用持续时间的更具体的类似物，以便对这些潜在的应用进行临床评估。胰腺D细胞中生长抑素的存在增加了它可能作为胰岛素和胰高血糖素释放的局部调节剂的可能性。显然，需要进一步的工作来描述控制生长抑素分泌的因素及其作用方式。这些研究可能会揭示一类新的由d细胞功能障碍引起的综合征。
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引用次数: 6
Neurotransmitters and control of pituitary function. 神经递质与脑垂体功能的控制。
Current topics in molecular endocrinology
Pub Date : 1976-01-01 DOI: 10.1007/978-1-4684-2598-7_4
C Kordon, M Hery, A Enjalbert
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引用次数: 13
The etiology of breast cancer. 乳腺癌的病因。
Current topics in molecular endocrinology
Pub Date : 1976-01-01 DOI: 10.1007/978-1-4684-2601-4_2
M A Rich, P Furmanski, C M McGrath, J McCormick, J Russo, H Soule
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引用次数: 24
Analogs of somatostatin. Part A. Chemistry and in vitro results. 生长抑素的类似物。第一部分:化学和体外结果。
Current topics in molecular endocrinology
Pub Date : 1976-01-01 DOI: 10.1007/978-1-4684-2598-7_20
H Immer, N A Abraham, V Nelson, K Sestanj, M Götz, P Brazeau, J B Martin
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引用次数: 0
Suppression of gonadotropin release and ovulation in animals by inhibitory analogs of luteinizing hormone-releasing hormone. 促性腺激素释放激素抑制类似物对动物促性腺激素释放和排卵的抑制作用。
Current topics in molecular endocrinology
Pub Date : 1976-01-01 DOI: 10.1007/978-1-4684-2598-7_18
D H Coy, E J Coy, J A Vilchez-Martinez, A de la Cruz, A Arimura, A V Schally
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引用次数: 9
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