American Journal of Otolaryngology最新文献

{"title":"Impact of intravenous drug use on neck abscess outcomes: 30-day readmission & 5-year survival rates","authors":"Elliott M. Sina ,&nbsp;Bryce Hambach ,&nbsp;Eric Mastrolonardo ,&nbsp;Sruti Tekumalla ,&nbsp;Meghan Crippen ,&nbsp;Richard Goldman","doi":"10.1016/j.amjoto.2025.104754","DOIUrl":"10.1016/j.amjoto.2025.104754","url":null,"abstract":"<div><h3>Objectives</h3><div>Injection drug use (IDU) is a known risk factor for neck abscesses, often requiring urgent surgical intervention by acute-care Otolaryngologists. However, data on the prevalence and long-term outcomes of IDU-related neck abscesses are limited. This study investigates differences in 30-day readmission rates and 5-year all-cause mortality between patients with and without a history of IDU hospitalized for neck abscesses.</div></div><div><h3>Methods</h3><div>This is a retrospective cohort study utilizing the TriNetX national clinical database. Patients hospitalized for neck abscesses (ICD-10: L02.11) were categorized into two cohorts: IDU (current/previous) and non-IDU. Demographics, 30-day readmission rates, and 5-year survival were analyzed. 1:1 Propensity score matching (PSM) was used to adjust for 15 covariates known to be associated with IDU-related neck abscesses, and a two-sample <em>t</em>-test was applied. Kaplan-Meier analysis was performed to assess 5-year survival.</div></div><div><h3>Results</h3><div>In a cohort of 32,655 patients (mean age: 54.7, 58.4 % female), PSM resulted in 2410 patients per cohort. IDU patients had higher 30-day readmission rates than controls (10.2 % vs 7.81 %; OR: 1.32; 95 % CI: 1.10–1.62; <em>p</em> = 0.0061) and lower 5-year survival (77.2 % vs 81.8 %; HR: 1.21).</div></div><div><h3>Conclusion</h3><div>Patients admitted for IDU-related neck abscesses have significantly higher 30-day readmission rates and decreased 5-year survival compared to non-IDU patients. These findings underscore the critical need for early detection and intervention by Otolaryngologists in this vulnerable population.</div></div>","PeriodicalId":7591,"journal":{"name":"American Journal of Otolaryngology","volume":"47 1","pages":"Article 104754"},"PeriodicalIF":1.7,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145740225","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Surgical strategy in submandibular sialolithiasis: Impact of stone location and size on approach selection and outcomes","authors":"Joo Hyun Kim","doi":"10.1016/j.amjoto.2025.104768","DOIUrl":"10.1016/j.amjoto.2025.104768","url":null,"abstract":"<div><h3>Purpose</h3><div>To evaluate how stone location and size influence surgical approach selection in submandibular sialolithiasis, and to identify computed tomography (CT)-based imaging predictors to aid preoperative planning.</div></div><div><h3>Methods</h3><div>We retrospectively reviewed 428 consecutive surgeries (March 2020–December 2024). Preoperative non-contrast CT classified stones as distal duct, mid-duct, hilum, or intraglandular. Surgical approaches were transoral ductal incision, sialendoscopy-assisted removal, and external submandibular gland excision. Group comparisons used standard parametric/non-parametric tests. Receiver operating characteristic (ROC) analysis assessed size thresholds associated with selection of an invasive approach.</div></div><div><h3>Results</h3><div>Distal duct stones were most often treated by transoral incision (83.7 %), mid-duct stones by sialendoscopy-assisted removal (58.1 %), and intraglandular stones by external excision (71.0 %). Stones in the hilum/intraglandular regions were significantly larger than those in distal or mid-duct locations (<em>p</em> &lt; 0.001). ROC analysis identified 5.5 mm as the optimal cutoff for predicting selection of an invasive approach (AUC = 0.83; sensitivity 74.2 %; specificity 78.9 %). Overall surgical success was 97.8 %. Complication rates varied by approach, lowest after sialendoscopy-assisted removal (4.4 %) and highest after external excision (15.2 %).</div></div><div><h3>Conclusions</h3><div>A simple CT-based framework incorporating stone location and size was associated with approach selection and outcomes in submandibular sialolithiasis. Using a 5.5 mm size threshold alongside anatomic zoning may help guide minimally invasive, gland-preserving strategies and reduce morbidity. Prospective validation is warranted.</div></div>","PeriodicalId":7591,"journal":{"name":"American Journal of Otolaryngology","volume":"47 1","pages":"Article 104768"},"PeriodicalIF":1.7,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145713001","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Preliminary study on classification and treatment of type I variant preauricular fistula","authors":"Haigang Zhang","doi":"10.1016/j.amjoto.2025.104782","DOIUrl":"10.1016/j.amjoto.2025.104782","url":null,"abstract":"","PeriodicalId":7591,"journal":{"name":"American Journal of Otolaryngology","volume":"47 1","pages":"Article 104782"},"PeriodicalIF":1.7,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145766879","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluating safety of observation after resection of low- and intermediate-grade major salivary cancers with isolated perineural invasion with or without facial nerve sacrifice","authors":"Alexandra T. Bourdillon ,&nbsp;Peter Callas ,&nbsp;Mirabelle Sajisevi ,&nbsp;Karolina A. Plonowska-Hirschfeld ,&nbsp;Andrew Holcomb ,&nbsp;William R. Ryan","doi":"10.1016/j.amjoto.2025.104773","DOIUrl":"10.1016/j.amjoto.2025.104773","url":null,"abstract":"<div><h3>Purpose</h3><div>The oncologic benefit of adjuvant radiotherapy (aRT) and the impact of facial nerve sacrifice have not been examined for early-stage low- and intermediate-grade salivary gland carcinomas (LIG-SGCs) with isolated perineural invasion (PNI) and no other adverse features.</div></div><div><h3>Methods</h3><div>Using a multi-institutional, international cohort established by the American Head and Neck Society (AHNS) Salivary Gland Section, we examined T1-2N0 LIG-SGCs, excluding tumor spillage, positive margins, positive lymphovascular invasion, and unreported PNI. We compared local recurrence rates between the isolated PNI and control arms. Multivariate hazard regression was used to evaluate the risk of local recurrence across PNI, adjuvant radiation therapy (aRT), and facial nerve sacrifice.</div></div><div><h3>Results</h3><div>Among 336 patients across 35 centers, 24 (7 %) patients had isolated PNI as the only high-risk feature. aRT was significantly more common among patients with isolated PNI (<em>n</em> = 10/24 or 42 %, RR: 2.32, 95 % CI: 1.37–3.94) than controls (<em>n</em> = 56/312 or 18 %). aRT was not significantly associated with local control, even after controlling for PNI and facial nerve sacrifice (HR: 0.34, 95 % CI: 0.04–3.06). Within the isolated PNI cohort, one recurrence occurred in the aRT group (<em>n</em> = 1/10, 10 %) and one in the group without aRT (n = 1/14 or 7 %). Thirty (91 %) patients who underwent facial nerve sacrifice had no PNI on final histopathology, with all 30 having full preoperative facial nerve function.</div></div><div><h3>Conclusions</h3><div>aRT may not necessarily reduce local recurrence for early-stage LIG-SGCs with isolated PNI. In patients with preoperative normal facial nerve function, facial nerve sacrifice may not be necessary.</div></div>","PeriodicalId":7591,"journal":{"name":"American Journal of Otolaryngology","volume":"47 1","pages":"Article 104773"},"PeriodicalIF":1.7,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145676144","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Risk factors for tonsillar hypertrophy and post-transplant lymphoproliferative disorder","authors":"Ross Rosen ,&nbsp;Jamil Hayden ,&nbsp;Jenna Rock ,&nbsp;Alexandra Welschmeyer ,&nbsp;Chelsea Cleveland ,&nbsp;Todd Otteson","doi":"10.1016/j.amjoto.2025.104756","DOIUrl":"10.1016/j.amjoto.2025.104756","url":null,"abstract":"<div><h3>Introduction</h3><div>Post-transplant lymphoproliferative disorder (PTLD) is a rare complication of immunosuppression in solid organ transplant patients. Tonsillar hypertrophy commonly results from PTLD, and tonsillectomy is usually performed when PTLD is the suspected cause. Risk factors for PTLD-mediated tonsillar hypertrophy remain poorly defined. This study aimed to identify clinical and therapeutic factors associated with tonsillar hypertrophy following PTLD diagnosis.</div></div><div><h3>Methods</h3><div>We conducted a retrospective cohort study using the TriNetX Database. Pediatric solid organ transplant recipients were queried for tonsil disease, tonsillectomy, PTLD diagnosis, transplant history, and immunosuppressants using the associated Current Procedural Terminology, International Classification of Diseases, and RxNorm codes.</div></div><div><h3>Results</h3><div>We identified 21,582 children with a history of solid organ transplant. Tonsil disease was found in 1833 (8.49 %), and of these patients, 193 (10.53 %) were diagnosed with PTLD within six months. Immunosuppressants associated with higher rates of tonsil disease were tacrolimus (OR 2.74, 95 % CI 2.29–3.28), mycophenolate mofetil (OR 2.72, 95 % CI 2.29–3.24), and cyclosporine (OR 1.50, 95 % CI 1.08–2.10). Sirolimus was associated with lower rates (OR 0.66, 95 % CI 0.52–0.83). EBV diagnosis was associated with both higher rates of tonsil disease (OR 1.45, 95 % CI 1.21–1.72) and PTLD diagnosis (OR 3.52, 95 % CI 2.14–5.77).</div></div><div><h3>Discussion</h3><div>This is the largest study on tonsillar hypertrophy in PTLD and the first to identify tacrolimus, mycophenolate mofetil, and cyclosporine as significant risk factors for tonsil disease amongst pediatric transplant patients. Understanding risk factors that may predispose a patient to PTLD-mediated tonsil disease can guide decision making to help avoid this complication of immunosuppression.</div></div>","PeriodicalId":7591,"journal":{"name":"American Journal of Otolaryngology","volume":"47 1","pages":"Article 104756"},"PeriodicalIF":1.7,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145676153","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Continuous positive airway pressure vs palatal surgery: Outcomes in obstructive sleep apnea treatment","authors":"Alec Kadrie ,&nbsp;Jonathan Laredo ,&nbsp;Evan Thomson ,&nbsp;M. Boyd Gillespie","doi":"10.1016/j.amjoto.2025.104776","DOIUrl":"10.1016/j.amjoto.2025.104776","url":null,"abstract":"<div><h3>Objective</h3><div>To compare short- and long-term clinical outcomes of continuous positive airway pressure versus palatal surgical interventions such as uvulopalatopharyngoplasty, including their impacts on sleep apnea-related cardiac, respiratory, and metabolic comorbidities.</div></div><div><h3>Study design</h3><div>Retrospective cohort study.</div></div><div><h3>Setting</h3><div>Database study using the TriNetX Network of Tennessee (2014–2024).</div></div><div><h3>Methods</h3><div>Adult patients diagnosed with obstructive sleep apnea and treated with either continuous positive airway pressure or palatal surgery were identified. Propensity score matching was performed to balance demographics and preexisting comorbidities between groups. Primary outcomes were cardiopulmonary events, and secondary outcomes were new-onset type 2 diabetes and weight change. Odds ratio with 95 % confidence intervals were computed across outcome measures.</div></div><div><h3>Results</h3><div>A total of 5030 continuous positive airway pressure and 220 palatal surgery patients met inclusion criteria. Following matching, 220 patients remained in each group. Patients treated with continuous positive airway pressure had significantly higher odds of post-treatment electronic medical record coding of acute respiratory failure (OR 4.67, [2.27, 9.60]), pulmonary hypertension (OR 20.0, [2.71, 147.7]), and new-onset atrial fibrillation/flutter (OR 3.32, [1.60, 6.96]) compared to the surgical cohort. No significant differences were observed in myocardial infarction, stroke, or new-onset type 2 diabetes.</div></div><div><h3>Conclusion</h3><div>Patients treated with continuous positive airway pressure had higher odds of post-treatment electronic medical recording coding of cardiorespiratory complications than those undergoing palatal surgery. These findings highlight potentially important differences between treatment modalities in long-term obstructive sleep apnea related comorbidities.</div></div>","PeriodicalId":7591,"journal":{"name":"American Journal of Otolaryngology","volume":"47 1","pages":"Article 104776"},"PeriodicalIF":1.7,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145691265","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Treatment preferences and values in chronic tinnitus patients: A cross-sectional survey study","authors":"Jeon Mi Lee ,&nbsp;Hyun Jung Kim ,&nbsp;Yong-Hwi An ,&nbsp;Ah. Rang Cho ,&nbsp;Jae Ho Chung ,&nbsp;Jae Sang Han ,&nbsp;Woojae Han ,&nbsp;Da Jung Jung ,&nbsp;Jung-Yup Lee ,&nbsp;Euyhyun Park ,&nbsp;Kyu-Yup Lee ,&nbsp;Ho Yun Lee","doi":"10.1016/j.amjoto.2026.104790","DOIUrl":"10.1016/j.amjoto.2026.104790","url":null,"abstract":"<div><h3>Purpose</h3><div>Tinnitus is a common condition that can severely impact patients' quality of life. However, little is known about how individuals with chronic tinnitus evaluate and prioritize available treatment options. This study aimed to explore the preferences, values and expectations of patients with chronic tinnitus to inform more patient-centered strategies in clinical care.</div></div><div><h3>Material and methods</h3><div>A cross-sectional survey was conducted from May 8 to June 19, 2025, involving 45 patients with chronic tinnitus. A structured 36-item questionnaire assessed demographic information, tinnitus severity using the Tinnitus Handicap Inventory (THI) and the Visual Analog Scale (VAS), treatment preferences across 16 key questions, perceived information needs, and impact on daily functioning.</div></div><div><h3>Results</h3><div>Participants (mean age 50.7 ± 14.8 years, 62.2% male, median tinnitus duration 12 months) showed strong preferences for non-invasive treatments: sound therapy (73.4%), tinnitus retraining therapy (TRT; 55.6%), and cognitive behavioral therapy (CBT; 44.4%). Pharmaceutical interventions had lower acceptance, with hearing aids showing highest rejection (33.3%). Key concerns included drug dependency (48.9%) and psychiatric medication stigma (28.9%). 51.1% of respondents expected complete symptom resolution despite limited evidence. Information needs were high across all modalities (40–50%). Sleep disorders (THI difference: 12.9 points) and anxiety (6.5 points) significantly associated with increased tinnitus severity.</div></div><div><h3>Conclusions</h3><div>Tinnitus patients strongly prefer non-invasive treatments while harboring unrealistic expectations for cure. These findings underscore the importance of structured education and shared decision-making to align clinical care with patient values and promote more effective tinnitus management.</div></div>","PeriodicalId":7591,"journal":{"name":"American Journal of Otolaryngology","volume":"47 1","pages":"Article 104790"},"PeriodicalIF":1.7,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145973015","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A clinical shift toward personalized cochlear implantation: Using preoperative planning to optimize insertion depth","authors":"Benjamin Bircher ,&nbsp;Philipp Aebischer ,&nbsp;Wilhelm Wimmer ,&nbsp;Georgios Mantokoudis ,&nbsp;Stephan Schraivogel ,&nbsp;Marco Caversaccio ,&nbsp;Stefan Weder","doi":"10.1016/j.amjoto.2025.104777","DOIUrl":"10.1016/j.amjoto.2025.104777","url":null,"abstract":"<div><h3>Objective:</h3><div>To evaluate the clinical implementation of preoperative, anatomy-tailored planning for electrode selection in cochlear implantation, quantify planning accuracy under routine conditions, and identify factors associated with deviations from the planned angular insertion depth (AID).</div></div><div><h3>Methods:</h3><div>We retrospectively analyzed 71 consecutive implantations; 17 cases were excluded due to unsuccessful segmentation/fusion, yielding 54 implanted ears. Before 2023 (Group A, <span><math><mrow><mi>n</mi><mo>=</mo><mn>32</mn></mrow></math></span>), electrode choice followed surgeon preference independent of cochlear duct length (CDL). From 2023 (Group B, <span><math><mrow><mi>n</mi><mo>=</mo><mn>22</mn></mrow></math></span>), automated OTOPLAN-based planning targeted an AID of 600° (cap 650°). Pre- and postoperative computed tomography scans provided cochlear metrics and postoperative AID. Planning accuracy was defined as the difference between planned and achieved AID. Linear models assessed demographic/clinical, anatomical, and surgical predictors. Speech outcomes at 6 months used Freiburger monosyllables at 65 dB HL.</div></div><div><h3>Results:</h3><div>Group B showed deeper and more consistent insertions (median AID 568° [IQR 62°]) than Group A (527° [IQR 99°]; <span><math><mrow><mi>p</mi><mo>&lt;</mo><mn>0</mn><mo>.</mo><mn>01</mn></mrow></math></span>). Median planning deviation was <span><math><mrow><mo>−</mo><msup><mrow><mn>9</mn></mrow><mrow><mo>∘</mo></mrow></msup></mrow></math></span> (IQR 78°) with no relationship to planned depth ( <span><math><mrow><msup><mrow><mi>R</mi></mrow><mrow><mn>2</mn></mrow></msup><mo>=</mo><mn>0</mn><mo>.</mo><mn>008</mn></mrow></math></span>, <span><math><mrow><mi>p</mi><mo>=</mo><mn>0</mn><mo>.</mo><mn>514</mn></mrow></math></span>). Greater inaccuracies were found in patients with shorter CDL (<span><math><mrow><mi>p</mi><mo>=</mo><mn>0</mn><mo>.</mo><mn>001</mn></mrow></math></span>) and in cases with observed intraoperative resistance (<span><math><mrow><mi>p</mi><mo>&lt;</mo><mn>0</mn><mo>.</mo><mn>001</mn></mrow></math></span>).</div></div><div><h3>Conclusion:</h3><div>cochlear anatomy exhibited substantial inter-individual variability. Implementing preoperative, anatomy-tailored planning was associated with the selection of longer arrays, deeper and more consistent AID, and overall high planning accuracy. Deviations from the planned position were primarily linked to shorter CDL and intraoperative resistance, whereas deeper targets themselves did not reduce accuracy. Audiological performance at 6 months did not differ significantly between groups, although a modest trend favored the planned cohort. These findings support the feasibility of routine, examiner-independent planning and suggest that patient-specific anatomical markers should inform the selection of an appropriate electrode array.</div></div>","PeriodicalId":7591,"journal":{"name":"American Journal of Otolaryngology","volume":"47 1","pages":"Article 104777"},"PeriodicalIF":1.7,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145910005","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Headache resolution following the middle fossa repair of superior semicircular canal dehiscence","authors":"Layla Ali ,&nbsp;Adam Ali ,&nbsp;Samuel Salib ,&nbsp;Niloufar S. Tehrani ,&nbsp;Hong-Ho Yang ,&nbsp;Khashayar Mozaffari ,&nbsp;Quinton Gopen","doi":"10.1016/j.amjoto.2025.104752","DOIUrl":"10.1016/j.amjoto.2025.104752","url":null,"abstract":"<div><h3>Objective</h3><div>To investigate predictors of headache resolution following surgical intervention for superior semicircular canal dehiscence (SSCD) syndrome.</div></div><div><h3>Method</h3><div>We conducted a retrospective chart review on 344 surgical repairs of SSCD via the middle cranial fossa (MCF) approach conducted at an institution. The primary outcome measure was the resolution of headaches after SSCD repair. Analyses explored the predictive potential of several comorbidities and lifestyle factors pre-operatively.</div></div><div><h3>Results</h3><div>Among a total of 344 repairs, 193 (56 %) reported headaches preoperatively. Among which, 114 (59 %) experienced headache resolution following surgery. Compared to patients without a history of general anxiety disorder (GAD), patients with GAD reported a 65 % lower odds of headache resolution following surgery (aOR 0.35, 95 % CI [0.14, 0.91]). Compared to patients without hypertension (HTN), patients with HTN were significantly more likely to experience headache resolution following surgery (aOR 4.65, [1.19, 18.22]).</div></div><div><h3>Conclusion</h3><div>A substantial portion of patients with headaches experienced resolution following SSCD repair (∼60 %). Patients with GAD were less likely to experience headache resolution following SSCD repair, whereas patients with HTN were more likely to experience headache resolution.</div><div>Level of Evidence: Level IV</div></div>","PeriodicalId":7591,"journal":{"name":"American Journal of Otolaryngology","volume":"47 1","pages":"Article 104752"},"PeriodicalIF":1.7,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145754740","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Stapokibart (CM310): A review in seasonal allergic rhinitis","authors":"Ping Xue ,&nbsp;Jing Yan ,&nbsp;Jianwei Li","doi":"10.1016/j.amjoto.2025.104765","DOIUrl":"10.1016/j.amjoto.2025.104765","url":null,"abstract":"<div><h3>Background</h3><div>Stapokibart (CM310), a humanized anti-IL-4Rα monoclonal antibody, blocks IL-4/IL-13 signaling for type 2 inflammatory diseases like seasonal allergic rhinitis (SAR), where standard of care often fails.</div></div><div><h3>Objective</h3><div>Assess stapokibart's efficacy on the primary endpoint (reflective Total Nasal Symptom Score, rTNSS) and safety as add-on therapy in SoC-inadequate moderate-to-severe SAR.</div></div><div><h3>Methods</h3><div>Data from a Phase II trial (MERAK, <em>n</em> = 92) and the pivotal Phase III PHECDA trial (<em>n</em> = 108; enriched for blood eosinophils ≥300 cells/μL) were reviewed. Patients received subcutaneous stapokibart (600 mg loading, then 300 mg Q2W) or placebo + SoC for 4 weeks.</div></div><div><h3>Results</h3><div>In MERAK, stapokibart Q2W showed a trend for rTNSS improvement (LSMD -1.0 vs placebo, <em>p</em> = 0.065). In PHECDA, stapokibart significantly improved rTNSS at Week 4 (LSMD -1.7, 95 % CI: −2.5, −0.8; <em>p</em> = 0.0002). Treatment-emergent adverse event rates were comparable to placebo in both trials (e.g., PHECDA: 52.0 % vs 46.6 %), mostly mild/moderate.</div></div><div><h3>Conclusion</h3><div>Add-on stapokibart is a valuable therapeutic option for adults with SoC-inadequate moderate-to-severe SAR and elevated eosinophils, providing statistically significant improvements in nasal symptoms and quality of life, with an acceptable safety profile.</div></div>","PeriodicalId":7591,"journal":{"name":"American Journal of Otolaryngology","volume":"47 1","pages":"Article 104765"},"PeriodicalIF":1.7,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145676074","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}