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Effectiveness of drug-induced sleep endoscopy in improving patients selection and outcomes of mandibular advancement device therapy for obstructive sleep apnea: A multicenter case-control study 药物诱导睡眠内窥镜在改善下颌推进装置治疗阻塞性睡眠呼吸暂停患者选择和疗效方面的有效性:一项多中心病例对照研究
IF 1.7 4区 医学 Q2 OTORHINOLARYNGOLOGY Pub Date : 2025-11-11 DOI: 10.1016/j.amjoto.2025.104740
Giannicola Iannella , Sergio Terranova , Marco Brunori , Claudio Vicini , Alberto Caranti , Ruggero Campisi , Vincenzo De Ceglie , Manuele Casale , Antonio Moffa , Fabrizio Salamanca , Federico Leone , Andrea De Vito , Giovanni Cammaroto , Salvatore Cocuzza , Antonino Maniaci , Armando De Virgilio , Jerome R. Lechien , Carlos-Miguel Chiesa-Estomba , Luigi A. Vaira , Paolo Boscolo-Rizzo , Annalisa Pace

Purpose

To evaluate, in Obstructive sleep apnea (OSA) patients, the use of pre-treatment drug-induced sleep endoscopy (DISE) as a patient selection tool, that could improve the outcomes of mandibular advancement device (MAD) therapy. A multicenter retrospective case-control study has been performed.

Methods

A multicenter case-control study with two parallel arms was conducted to compare functional outcomes in patients undergoing MAD therapy. Group A (n = 118) received MAD therapy based solely on static clinical assessments, including dentoskeletal features, oropharyngeal anatomy, and upper airway endoscopy. Group B (n = 87) underwent pre-treatment DISE to dynamically evaluate the site, type, and pattern of upper airway collapse, thereby guiding patient selection for MAD therapy.

Results

In Group A, the mean pre-treatment apnea-hypopnea index (AHI) was 28.1, decreasing significantly to 12.4 post-treatment (p = 0.0001). In Group B, the mean AHI decreased from 31.3 to 9.5 (p = 0.0001). The Delta apnea-hypopnea index (ΔAHI) was significantly greater in Group B (−21.7) than in Group A (−16.6; p = 0.04). Similarly, the Delta Oxigen desaturation index (ΔODI) was −18.6 in Group B versus −14.1 in Group A (p = 0.04). The therapeutic success rate was significantly higher in Group B (82.7 %) compared to Group A (60.1 %) (p = 0.001).

Conclusion

In OSA patients, a pre-treatment DISE evaluation, improves the selection of appropriate candidates for MAD therapy by enabling dynamic assessment of upper airway collapsibility during a pharmacologically induced sleep. This targeted selection results in significantly better therapeutic outcomes for MAD therapy for the OSA treatment.
目的探讨在阻塞性睡眠呼吸暂停(OSA)患者中,治疗前药物诱导睡眠内镜(DISE)作为患者选择工具,对下颌推进装置(MAD)治疗效果的影响。进行了一项多中心回顾性病例对照研究。方法采用双平行臂多中心病例对照研究,比较MAD治疗患者的功能结局。A组(n = 118)仅根据静态临床评估(包括牙骨骼特征、口咽解剖和上呼吸道内窥镜检查)接受MAD治疗。B组(n = 87)在治疗前进行DISE,动态评估上呼吸道塌陷的部位、类型和模式,指导患者选择MAD治疗方案。结果A组患者治疗前平均呼吸暂停低通气指数(AHI)为28.1,治疗后为12.4,差异有统计学意义(p = 0.0001)。B组平均AHI从31.3降至9.5 (p = 0.0001)。B组δ呼吸暂停低通气指数(ΔAHI)(- 21.7)显著高于A组(- 16.6,p = 0.04)。同样,B组的δ氧去饱和指数(ΔODI)为−18.6,而A组为−14.1 (p = 0.04)。B组治疗成功率(82.7%)明显高于A组(60.1%)(p = 0.001)。结论在OSA患者中,治疗前的DISE评估可以通过动态评估药理学诱导睡眠期间的上呼吸道塌陷性来改善对合适的MAD治疗候选者的选择。这种有针对性的选择使MAD治疗OSA的治疗效果明显更好。
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引用次数: 0
Machine learning model for predicting hearing preservation after vestibular schwannoma surgery: A meta-analysis 预测前庭神经鞘瘤手术后听力保存的机器学习模型:荟萃分析。
IF 1.7 4区 医学 Q2 OTORHINOLARYNGOLOGY Pub Date : 2025-11-01 DOI: 10.1016/j.amjoto.2025.104727
Paweł Łajczak , Emma Ann Finnegan , Enzo von Quednow , Fabio Victor Vieira Rocha , Yasmin Picanço Silva , Oguz Kagan Sahin , Walter Fagundes

Introduction

Vestibular schwannomas (VS) are benign tumors that can cause hearing loss, tinnitus and balance disorders. Radiosurgery and open surgery remain the primary treatments, but predicting hearing preservation post-surgery remains challenging due to a variety of factors. Machine learning (ML) has emerged as a promising tool for predicting hearing outcomes in VS patients. This meta-analysis aims to systematically evaluate the diagnostic accuracy of ML models in predicting hearing preservation in VS patients undergoing surgery.

Methods

We conducted a systematic review and meta-analysis following PRISMA-DTA guidelines, including studies that applied ML to predict hearing preservation in VS patients undergoing surgery. Studies were selected based on predefined inclusion criteria, and diagnostic accuracy metrics, such as sensitivity, specificity and accuracy were extracted.

Results

A total of 15 models from 3 studies were included. The overall pooled sensitivity was 0.856 (95% CI 0.758–0.919), specificity was 0.853 (95% CI 0.713–0.931), and accuracy was 0.839 (95% CI 0.748–0.902). The area under the summary ROC curve was 0.883 (95% CI 0.770–0.910), indicating high diagnostic effectiveness. Significant heterogeneity was observed.

Conclusions

ML models achieve high accuracy in predicting hearing preservation in VS patients undergoing surgery. However, significant heterogeneity exists across studies, indicating the need for further research to optimize model performance and enhance their generalizability across diverse patient populations. ML has the potential to assist clinicians in providing personalized treatment strategies and improving patient outcomes in the management of vestibular schwannomas.
前庭神经鞘瘤(VS)是一种良性肿瘤,可引起听力损失、耳鸣和平衡障碍。放疗和开放手术仍然是主要的治疗方法,但由于各种因素,预测术后听力保留仍然具有挑战性。机器学习(ML)已成为预测VS患者听力结果的一种有前途的工具。本荟萃分析旨在系统评估ML模型在预测接受手术的VS患者听力保留方面的诊断准确性。方法:我们根据PRISMA-DTA指南进行了系统回顾和荟萃分析,包括应用ML预测接受手术的VS患者听力保留的研究。根据预定义的纳入标准选择研究,提取诊断准确性指标,如敏感性、特异性和准确性。结果:共纳入3项研究的15个模型。总体合并敏感性为0.856 (95% CI 0.758-0.919),特异性为0.853 (95% CI 0.713-0.931),准确性为0.839 (95% CI 0.748-0.902)。综合ROC曲线下面积为0.883 (95% CI 0.77 ~ 0.910),诊断效能高。观察到显著的异质性。结论:ML模型在预测VS手术患者的听力保留方面具有较高的准确性。然而,各研究之间存在显著的异质性,表明需要进一步研究以优化模型性能并增强其在不同患者群体中的普遍性。ML有可能帮助临床医生提供个性化的治疗策略,并改善前庭神经鞘瘤的治疗结果。
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引用次数: 0
National trends in the utilization of office-based transnasal esophagoscopy 全国办公室经鼻食管镜检查应用趋势
IF 1.7 4区 医学 Q2 OTORHINOLARYNGOLOGY Pub Date : 2025-11-01 DOI: 10.1016/j.amjoto.2025.104746
Lauren Kwa , Ashley Bodnar , Maxwell Scher , Jacob Pieter Noordzij , Lauren Tracy

Objective

To analyze national trends in the prevalence of office-based transnasal esophagoscopy (TNE) procedures and compare with traditional operating room-based procedures utilizing transoral flexible and rigid esophagoscopy.

Methods

From 2013 to 2022, the US Medicare Part B claims database was searched for Current Procedural Terminology (CPT) codes 43,197/43198: diagnostic transnasal flexible esophagoscopy/with biopsy, 43200/43202: diagnostic transoral flexible esophagoscopy/with biopsy, 43191/43193: diagnostic rigid esophagoscopy/with biopsy. For each CPT code, the total number of charges billed to the Medicare database in each calendar year were recorded and analyzed using trendlines and linear regression.

Results

From 2013 to 2022, there was a significant decrease in the prevalence of transoral flexible esophagoscopy, both diagnostic (trendline slope = −1078, R2 = 0.83) and with biopsy (trendline slope = −192, R2 = 0.80). The prevalence of rigid esophagoscopy, both diagnostic and with biopsy, remained stable (trendline slope = −51, R2 = 0.14; trendline slope = −9.6, R2 = 0.26, respectively). Diagnostic TNE represented a small percentage of total diagnostic esophagoscopies performed (range: 9.37–14.94 %), and this percentage remained relatively constant over time (trendline slope = 0.0017, R2 = 0.08). TNE with biopsy was a small percentage of total esophageal biopsy procedures (range: 6.54–10.66 %), with a slight increase over time as a percentage of all esophageal biopsies performed (trendline slope = 0.0037, R2 = 0.48).

Conclusion

Benefits of office-based TNE procedures include the avoidance of general anesthesia, shorter procedure times, and cost savings. However, TNE remains a small percentage of all esophagoscopies performed, without significant trends toward increased utilization. Further investigation is needed to evaluate the lack of utilization of these office-based procedures.
目的分析全国办公室经鼻食管镜(TNE)手术的流行趋势,并与传统的手术室经口柔性和刚性食管镜手术进行比较。方法从2013年至2022年,检索美国医疗保险B部分索赔数据库,检索当前程序术语(CPT)代码43197 /43198:诊断性经鼻柔性食管镜/活检,43200/43202:诊断性经口柔性食管镜/活检,43191/43193:诊断性刚性食管镜/活检。对于每个CPT代码,每个日历年向医疗保险数据库收取的费用总数被记录下来,并使用趋势线和线性回归进行分析。结果从2013年到2022年,经口柔性食管镜诊断(趋势线斜率= - 1078,R2 = 0.83)和活检(趋势线斜率= - 192,R2 = 0.80)的患病率均显著下降。诊断性和活检性硬食管镜检查的患病率保持稳定(趋势线斜率= - 51,R2 = 0.14;趋势线斜率= - 9.6,R2 = 0.26)。诊断性TNE占全部诊断性食管镜检查的一小部分(范围:9.37 - 14.94%),这一比例随着时间的推移保持相对恒定(趋势线斜率= 0.0017,R2 = 0.08)。活检的TNE占食管活检总手术的百分比很小(范围:6.54 - 10.66%),随着时间的推移,TNE在所有食管活检中所占的百分比略有增加(趋势线斜率= 0.0037,R2 = 0.48)。结论办公室TNE手术的优点是避免了全身麻醉,缩短了手术时间,节省了费用。然而,TNE仍然占所有食管镜检查的一小部分,没有明显的增加使用的趋势。需要进一步调查以评价缺乏利用这些办公室程序的情况。
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引用次数: 0
Audiovisual speech perception in Mandarin cochlear implant users across age and listening conditions 中文人工耳蜗使用者不同年龄及听力状况之视听言语知觉。
IF 1.7 4区 医学 Q2 OTORHINOLARYNGOLOGY Pub Date : 2025-11-01 DOI: 10.1016/j.amjoto.2025.104741
Wen-Ching Chuang , Chia-Chen Lin , Yu-Chien Wang , Shih-Lung Chen , Che-Ming Wu

Objective

To investigate how visual cues influence speech recognition in Mandarin-speaking cochlear implant (CI) users and examine age-related differences in audiovisual (AV) integration across varying sound intensities and noise conditions.

Design

A cross-sectional observational study comparing performance in visual-only (VO), audio-only (AO), and AV conditions using standardized Mandarin monosyllabic word and sentence tests. Study Sample: Seventy-two participants were recruited, including 40 CI users (22 children, 18 adults) and 32 normal-hearing (NH) controls (16 children, 16 adults). All CI users were unilateral recipients of Cochlear™ Nucleus® devices.

Results

AV input significantly enhanced word recognition in CI users, particularly under degraded conditions (low intensity or high noise), consistent with the principle of inverse effectiveness. CI children outperformed adults in AV word tasks, whereas adults had better sentence comprehension. VO performance was comparable between CI and NH groups, suggesting effective visual compensation among CI users. The most pronounced AV benefit was observed at 0 dB signal-to-noise ratio, where AV sentence scores approached AO performance at +5 dB.

Conclusion

AV cues play a critical role in speech perception for Mandarin-speaking CI users, especially under acoustically challenging conditions. Age-specific patterns in AV integration suggest differential reliance on visual input and linguistic strategies. These findings support the inclusion of AV and VO tasks in clinical assessments and underscore the importance of multimodal rehabilitation approaches, particularly for pediatric CI users.
目的:研究视觉线索如何影响普通话人工耳蜗使用者的语音识别,并研究不同声强和噪声条件下视听整合的年龄相关差异。设计:一项横断面观察性研究,通过标准化的普通话单音节单词和句子测试,比较纯视觉(VO)、纯听觉(AO)和纯视听条件下的表现。研究样本:招募了72名参与者,包括40名CI使用者(22名儿童,18名成人)和32名正常听力(NH)对照组(16名儿童,16名成人)。所有CI使用者均为Cochlear™Nucleus®装置的单侧受者。结果:AV输入显著增强了CI用户的单词识别,特别是在退化条件下(低强度或高噪声),符合反向有效性原则。CI儿童在AV单词任务中表现优于成年人,而成年人在句子理解方面表现更好。CI组和NH组之间的VO表现相当,表明CI用户之间存在有效的视觉补偿。在0 dB信噪比时观察到最明显的AV益处,其中AV句子分数接近+5 dB时的AO表现。结论:AV线索在普通话CI使用者的语音感知中起着关键作用,特别是在具有声学挑战性的条件下。视音频整合的年龄特异性模式表明对视觉输入和语言策略的不同依赖。这些发现支持将AV和VO任务纳入临床评估,并强调了多模式康复方法的重要性,特别是对于儿科CI使用者。
{"title":"Audiovisual speech perception in Mandarin cochlear implant users across age and listening conditions","authors":"Wen-Ching Chuang ,&nbsp;Chia-Chen Lin ,&nbsp;Yu-Chien Wang ,&nbsp;Shih-Lung Chen ,&nbsp;Che-Ming Wu","doi":"10.1016/j.amjoto.2025.104741","DOIUrl":"10.1016/j.amjoto.2025.104741","url":null,"abstract":"<div><h3>Objective</h3><div>To investigate how visual cues influence speech recognition in Mandarin-speaking cochlear implant (CI) users and examine age-related differences in audiovisual (AV) integration across varying sound intensities and noise conditions.</div></div><div><h3>Design</h3><div>A cross-sectional observational study comparing performance in visual-only (VO), audio-only (AO), and AV conditions using standardized Mandarin monosyllabic word and sentence tests. Study Sample: Seventy-two participants were recruited, including 40 CI users (22 children, 18 adults) and 32 normal-hearing (NH) controls (16 children, 16 adults). All CI users were unilateral recipients of Cochlear™ Nucleus® devices.</div></div><div><h3>Results</h3><div>AV input significantly enhanced word recognition in CI users, particularly under degraded conditions (low intensity or high noise), consistent with the principle of inverse effectiveness. CI children outperformed adults in AV word tasks, whereas adults had better sentence comprehension. VO performance was comparable between CI and NH groups, suggesting effective visual compensation among CI users. The most pronounced AV benefit was observed at 0 dB signal-to-noise ratio, where AV sentence scores approached AO performance at +5 dB.</div></div><div><h3>Conclusion</h3><div>AV cues play a critical role in speech perception for Mandarin-speaking CI users, especially under acoustically challenging conditions. Age-specific patterns in AV integration suggest differential reliance on visual input and linguistic strategies. These findings support the inclusion of AV and VO tasks in clinical assessments and underscore the importance of multimodal rehabilitation approaches, particularly for pediatric CI users.</div></div>","PeriodicalId":7591,"journal":{"name":"American Journal of Otolaryngology","volume":"46 6","pages":"Article 104741"},"PeriodicalIF":1.7,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145407910","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Oncocytic lipoadenoma of the submandibular gland case report 颌下腺嗜瘤性脂肪腺瘤1例报告。
IF 1.7 4区 医学 Q2 OTORHINOLARYNGOLOGY Pub Date : 2025-11-01 DOI: 10.1016/j.amjoto.2025.104749
Mina A. Beshy , Fayssal Alqudrah , Isago Jerrett , Andrew M. Parrott , Taha A. Mur

Introduction

Oncocytic lipoadenomas represent a rare, benign variant of salivary gland tumors (SGT). The parotid gland is the most common location for these tumors, accounting for 85 % of cases, followed by the submandibular gland. There have only been 7 reported cases of submandibular gland oncocytic lipoadenomas documented to date.

Main concerns

Herein, we present a case of an asymptomatic 47-year-old female with no significant past medical history who was incidentally diagnosed with a mass of the submandibular gland. We proceeded with complete surgical excision of the left submandibular gland, along with a neck dissection to ensure the removal of any potentially neoplastic tissue.

Primary diagnosis and outcomes

Histopathologic analysis of the excised mass revealed lobulated adipocytic tissue intermixed with small, scattered foci of salivary gland tissue, and several areas of oncocytic glandular tissue surrounded by patchy chronic inflammation, consistent with previously reported findings of oncocytic lipoadenomas.

Conclusions

This case underscores the rarity of this benign entity and highlights its inclusion in the differential diagnosis of salivary gland masses. Furthermore, it emphasizes the importance of diagnostic imaging and histopathologic analysis following core needle biopsy, as biopsy alone may not provide sufficient diagnostic clarity.
嗜细胞性脂腺瘤是一种罕见的、良性的唾液腺肿瘤(SGT)。腮腺是这些肿瘤最常见的部位,占85%的病例,其次是下颌腺。迄今为止,只有7例报告的颌下腺嗜瘤性脂肪腺瘤。主要关注:在此,我们提出一例无症状的47岁女性,没有明显的既往病史,偶然被诊断为颌下腺肿块。我们进行了左侧颌下腺的完整手术切除,同时进行了颈部清扫,以确保切除任何潜在的肿瘤组织。初步诊断和结果:切除肿块的组织病理学分析显示分叶状脂肪细胞组织与小而分散的唾液腺组织混杂在一起,几个嗜瘤细胞腺组织区域被斑片状慢性炎症包围,与先前报道的嗜瘤细胞脂肪腺瘤的结果一致。结论:本病例强调了这种良性实体的罕见性,并强调了其在涎腺肿块鉴别诊断中的重要性。此外,它强调了核心针活检后诊断成像和组织病理学分析的重要性,因为单独活检可能无法提供足够的诊断清晰度。
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引用次数: 0
HSNet: An adaptive fusion network based on laryngoscope–speech multimodal data for laryngeal disease classification 基于喉镜-语音多模态数据的喉疾病分类自适应融合网络。
IF 1.7 4区 医学 Q2 OTORHINOLARYNGOLOGY Pub Date : 2025-11-01 DOI: 10.1016/j.amjoto.2025.104731
Mei Wei , Xiu Zhang , Lei Geng , Wei Wang , Zhitao Xiao , Yanbei Liu

Objective

To design and implement a deep learning-based multimodal data fusion classification model that integrates laryngoscope images and voice signals to improve the diagnostic accuracy of laryngeal diseases, enabling rapid and precise identification for clinical support.

Results

The model demonstrated high classification accuracy and robustness, achieving an overall accuracy of 87.92 % on the independent test set. Precision, recall, specificity, and F1-score were 0.879, 0.887, 0.966, and 0.883, respectively. The model outperformed single-modal approaches and existing multimodal frameworks.

Conclusion

The proposed HSNet effectively integrates hierarchical features from laryngoscope images and voice modalities, enabling accurate classification of six laryngeal diseases. This method holds significant potential for clinical applications.
目的:设计并实现一种融合喉镜图像和语音信号的基于深度学习的多模态数据融合分类模型,以提高喉部疾病的诊断准确率,实现快速、准确的识别,为临床提供支持。结果:该模型具有较高的分类精度和鲁棒性,在独立测试集上的总体准确率达到87.92%。精密度、召回率、特异性和f1评分分别为0.879、0.887、0.966和0.883。该模型优于单模态方法和现有的多模态框架。结论:提出的HSNet有效地整合了喉镜图像和语音模式的分层特征,能够对六种喉部疾病进行准确分类。该方法具有重要的临床应用潜力。
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引用次数: 0
Utility of apparent diffusion coefficient values in preoperative MRI for sinonasal tumors: Categorization of benign tumors excluding Papillomas, Papillomas, and malignant tumors 鼻窦肿瘤术前MRI中表观扩散系数值的应用:良性肿瘤的分类,不包括乳头状瘤、乳头状瘤和恶性肿瘤
IF 1.7 4区 医学 Q2 OTORHINOLARYNGOLOGY Pub Date : 2025-11-01 DOI: 10.1016/j.amjoto.2025.104738
Mami Matsunaga , Masahiro Kikuchi , Yuji Kitada , Takayuki Nakagawa , Sho Koyasu , Yuji Nakamoto , Koichi Omori

Objective

The apparent diffusion coefficient (ADC), obtained from diffusion-weighted imaging (DWI) on MRI, quantifies water diffusion within tissues and is commonly used to distinguish benign from malignant tumors. In the sinonasal region, preoperative diagnosis is often challenging due to diverse histologies and limited biopsy samples. This study aimed to assess the utility of ADCmean values in categorizing sinonasal tumors into benign tumors (excluding papillomas), papillomas, and malignant tumors, and to evaluate their potential as a supplementary diagnostic tool.

Methods

We retrospectively analyzed 74 patients with sinonasal tumors who underwent surgery between January 2011 and April 2022 and had preoperative DWI-MRI for ADC measurement. Tumors were classified into three groups based on final pathology: benign tumors excluding papillomas (12 cases), papillomas (28 cases), and malignant tumors (34 cases). Receiver operating characteristic (ROC) analysis was used to determine ADCmean cutoff values for each category. Diagnostic accuracy of ADC-based classification was compared with that of preoperative biopsy. Additionally, 8 cases without biopsy due to technical or safety concerns were assessed using ADCmean values alone.

Results

Mean ADC values significantly differed across groups: 1.89 ± 0.37 × 10−3 mm2/s for benign tumors excluding papillomas, 1.38 ± 0.33 × 10−3 mm2/s for papillomas, and 1.06 ± 0.27 × 10−3 mm2/s for malignant tumors. ROC analysis yielded optimal cutoff values: >1.57 for benign tumors excluding papillomas, 1.23–1.57 for papillomas, and < 1.23 for malignant tumors. Based on these thresholds, tumors were categorized into high (>1.57), intermediate (1.23–1.57), and low (<1.23) ADC groups. ADC-based classification achieved 68.9 % accuracy (51/74), lower than biopsy (95.4 %, 63/66), but correctly predicted tumor categories in all three cases where biopsy results were discordant with final pathology. In 8 cases without biopsy, ADC-based categorization achieved 87.5 % accuracy (7/8).

Conclusion

ADCmean values from DWI-MRI can effectively differentiate between benign tumors excluding papillomas, papillomas, and malignant tumors. Although not as accurate as biopsy, ADC-based categorization adds diagnostic value, especially in cases where biopsy is inconclusive or infeasible. Combining ADC analysis with biopsy findings may improve preoperative diagnostic accuracy and assist clinical decision-making in managing sinonasal tumors.
目的磁共振成像(MRI)弥散加权成像(DWI)获得的表观弥散系数(ADC)可量化组织内水分的弥散,是区分肿瘤良恶性的常用指标。在鼻窦区,由于不同的组织学和有限的活检样本,术前诊断往往具有挑战性。本研究旨在评估ADCmean在将鼻窦肿瘤分为良性肿瘤(不包括乳头状瘤)、乳头状瘤和恶性肿瘤中的应用,并评估其作为辅助诊断工具的潜力。方法回顾性分析2011年1月至2022年4月间接受手术的74例鼻窦肿瘤患者,术前行DWI-MRI测量ADC。肿瘤根据最终病理分为良性肿瘤(不包括乳头状瘤)12例、乳头状瘤(28例)、恶性肿瘤(34例)3组。采用受试者工作特征(ROC)分析确定每个类别的ADCmean截止值。比较adc分级与术前活检的诊断准确性。此外,由于技术或安全考虑,8例未活检的病例单独使用ADCmean值进行评估。结果各组平均ADC值差异显著:良性肿瘤(不包括乳头状瘤)为1.89±0.37 × 10−3 mm2/s,乳头状瘤为1.38±0.33 × 10−3 mm2/s,恶性肿瘤为1.06±0.27 × 10−3 mm2/s。ROC分析得出最佳截断值:良性肿瘤(不包括乳头状瘤)为>;1.57,乳头状瘤为1.23 - 1.57,恶性肿瘤为<; 1.23。基于这些阈值,将肿瘤分为高ADC组(>1.57)、中ADC组(< 1.57)和低ADC组(<1.23)。基于adc的分类准确率为68.9%(51/74),低于活检(95.4%,63/66),但在活检结果与最终病理不一致的三例病例中,均能正确预测肿瘤类别。在8例未活检的病例中,基于adc的分类准确率达到87.5%(7/8)。结论DWI-MRI的adc均值能有效鉴别除乳头状瘤外的良性肿瘤、乳头状瘤和恶性肿瘤。虽然不像活检那样准确,但基于adc的分类增加了诊断价值,特别是在活检不确定或不可行的情况下。将ADC分析与活检结果相结合可以提高术前诊断的准确性,帮助临床决策治疗鼻窦肿瘤。
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引用次数: 0
The clinical effect of second needle aspiration and repeated cytological investigation for same thyroid nodule 同一甲状腺结节二次穿刺及反复细胞学检查的临床效果。
IF 1.7 4区 医学 Q2 OTORHINOLARYNGOLOGY Pub Date : 2025-11-01 DOI: 10.1016/j.amjoto.2025.104737
Tzahi Neuman , Nir Zontag , Karin Atlan , Haggi Mazeh , Nir Hirshoren

Introduction

Thyroid nodules initially classified as Bethesda categories II, III, or IV are occasionally re-aspirated due to evolving clinical or ultrasonographic features, or as part of structured protocols. This real-world study aimed to (1) determine the frequency of changes in Bethesda classification following repeat fine-needle aspiration (FNA), (2) assess the relationship between Bethesda category shifts and the clinical indication for re-aspiration, and (3) evaluate malignancy rates in nodules that demonstrated cytologic reclassification.

Methods

A retrospective analysis of thyroid nodules that underwent more than one FNA between 2018 and 2024. Only nodules initially categorized as Bethesda II, III, or IV were included. Cytological outcomes were compared between the initial and repeat aspirations.

Results

A total of 429 nodules underwent repeat FNA, with 111 nodules meeting inclusion criteria. Among nodules initially classified as Bethesda II (benign), 40.4 % were upgraded to a higher Bethesda category on repeat aspiration. For nodules initially categorized as Bethesda III or IV, 13.6 and 21.6 % were upgraded, while 40.6 and 48.6 % were downgraded to a lower-risk category, respectively.
Malignancy rates correlated with upgraded cytology classifications: 55.6–80 % of nodules reclassified as Bethesda III / IV were malignant, while 66.7–100 % of nodules upgraded to Bethesda V / VI were confirmed as malignant on final pathology.

Conclusions

Repeat FNA of thyroid nodules - particularly when prompted by clinical assessment, sonographic changes, and institutional guidelines for indeterminate cytology - can significantly refine risk stratification. These findings support the high diagnostic utility of repeated aspiration in appropriate clinical scenarios.
简介:最初被归类为Bethesda II、III或IV类的甲状腺结节,由于临床或超声特征的变化,或作为结构化方案的一部分,偶尔会再次抽吸。这项现实世界的研究旨在(1)确定重复细针抽吸(FNA)后Bethesda分类变化的频率,(2)评估Bethesda分类变化与再次抽吸的临床指征之间的关系,以及(3)评估显示细胞学再分类的结节的恶性率。方法:回顾性分析2018年至2024年间接受1次以上FNA的甲状腺结节。仅包括最初归类为Bethesda II、III或IV的结节。比较首次和重复穿刺的细胞学结果。结果:共有429例结节接受了重复FNA治疗,其中111例符合纳入标准。在最初被分类为Bethesda II(良性)的结节中,40.4%在重复抽吸后升级到更高的Bethesda类别。对于最初被归类为Bethesda III或IV的结节,分别有13.6%和21.6%的结节升级,而40.6%和48.6%的结节被降级为低风险类别。恶性率与升级的细胞学分类相关:55.6- 80%的结节重新分类为Bethesda III / IV为恶性,而66.7- 100%的结节升级为Bethesda V / VI最终病理证实为恶性。结论:甲状腺结节的重复FNA -特别是当临床评估、超声检查改变和不确定细胞学的机构指南提示时-可以显着改善风险分层。这些发现支持在适当的临床情况下反复穿刺的高诊断效用。
{"title":"The clinical effect of second needle aspiration and repeated cytological investigation for same thyroid nodule","authors":"Tzahi Neuman ,&nbsp;Nir Zontag ,&nbsp;Karin Atlan ,&nbsp;Haggi Mazeh ,&nbsp;Nir Hirshoren","doi":"10.1016/j.amjoto.2025.104737","DOIUrl":"10.1016/j.amjoto.2025.104737","url":null,"abstract":"<div><h3>Introduction</h3><div>Thyroid nodules initially classified as Bethesda categories II, III, or IV are occasionally re-aspirated due to evolving clinical or ultrasonographic features, or as part of structured protocols. This real-world study aimed to (1) determine the frequency of changes in Bethesda classification following repeat fine-needle aspiration (FNA), (2) assess the relationship between Bethesda category shifts and the clinical indication for re-aspiration, and (3) evaluate malignancy rates in nodules that demonstrated cytologic reclassification.</div></div><div><h3>Methods</h3><div>A retrospective analysis of thyroid nodules that underwent more than one FNA between 2018 and 2024. Only nodules initially categorized as Bethesda II, III, or IV were included. Cytological outcomes were compared between the initial and repeat aspirations.</div></div><div><h3>Results</h3><div>A total of 429 nodules underwent repeat FNA, with 111 nodules meeting inclusion criteria. Among nodules initially classified as Bethesda II (benign), 40.4 % were upgraded to a higher Bethesda category on repeat aspiration. For nodules initially categorized as Bethesda III or IV, 13.6 and 21.6 % were upgraded, while 40.6 and 48.6 % were downgraded to a lower-risk category, respectively.</div><div>Malignancy rates correlated with upgraded cytology classifications: 55.6–80 % of nodules reclassified as Bethesda III / IV were malignant, while 66.7–100 % of nodules upgraded to Bethesda V / VI were confirmed as malignant on final pathology.</div></div><div><h3>Conclusions</h3><div>Repeat FNA of thyroid nodules - particularly when prompted by clinical assessment, sonographic changes, and institutional guidelines for indeterminate cytology - can significantly refine risk stratification. These findings support the high diagnostic utility of repeated aspiration in appropriate clinical scenarios.</div></div>","PeriodicalId":7591,"journal":{"name":"American Journal of Otolaryngology","volume":"46 6","pages":"Article 104737"},"PeriodicalIF":1.7,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145407754","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Advances in absorbable hemostatic materials for nasal bleeding and post-sinus surgery 鼻出血及鼻窦术后可吸收止血材料的研究进展
IF 1.7 4区 医学 Q2 OTORHINOLARYNGOLOGY Pub Date : 2025-11-01 DOI: 10.1016/j.amjoto.2025.104732
Weiguo Li , Shengqi Gan , Gong Liang , Linrong Wu , Junjun Zhang , Jiangyu Yan , Dong Ye
Nasal bleeding, especially following nasal or sinus surgery, significantly impacts patient recovery. Traditional hemostatic methods no longer meet the clinical needs of patients. With the advancement of treatment options for nasal bleeding, absorbable hemostatic materials, known for their excellent biocompatibility and degradability, have garnered widespread attention in the field of nasal hemostasis. This article aims to review the recent progress in research on hemostatic materials for nasal bleeding and post-operative nasal surgery. It analyzes the mechanisms of action of various types of hemostatic materials, including collagen-based, cellulose-based, alginate-based, and platelet-rich plasma (PRP) materials, discussing their clinical applications, advantages, and limitations. Finally, the article explores the future direction of nasal hemostatic materials, particularly the innovative development of bioactive absorbable materials and their potential applications in nasal bleeding. Overall, with the continuous emergence of novel materials, nasal hemostatic materials are expected to play an increasingly vital role in improving therapeutic outcomes, reducing recurrence, and enhancing the quality of life for patients.
鼻出血,特别是鼻或鼻窦手术后,严重影响患者的康复。传统的止血方法已不能满足患者的临床需要。随着鼻出血治疗方法的不断进步,可吸收性止血材料因其良好的生物相容性和可降解性而受到鼻止血领域的广泛关注。本文就鼻出血及鼻术后止血材料的研究进展作一综述。它分析了各种止血材料的作用机制,包括胶原蛋白基、纤维素基、海藻酸盐基和富血小板血浆(PRP)材料,讨论了它们的临床应用、优点和局限性。最后,探讨了鼻腔止血材料的未来发展方向,特别是生物活性可吸收材料的创新发展及其在鼻腔出血中的潜在应用。总之,随着新材料的不断涌现,鼻腔止血材料有望在改善治疗效果、减少复发、提高患者生活质量等方面发挥越来越重要的作用。
{"title":"Advances in absorbable hemostatic materials for nasal bleeding and post-sinus surgery","authors":"Weiguo Li ,&nbsp;Shengqi Gan ,&nbsp;Gong Liang ,&nbsp;Linrong Wu ,&nbsp;Junjun Zhang ,&nbsp;Jiangyu Yan ,&nbsp;Dong Ye","doi":"10.1016/j.amjoto.2025.104732","DOIUrl":"10.1016/j.amjoto.2025.104732","url":null,"abstract":"<div><div>Nasal bleeding, especially following nasal or sinus surgery, significantly impacts patient recovery. Traditional hemostatic methods no longer meet the clinical needs of patients. With the advancement of treatment options for nasal bleeding, absorbable hemostatic materials, known for their excellent biocompatibility and degradability, have garnered widespread attention in the field of nasal hemostasis. This article aims to review the recent progress in research on hemostatic materials for nasal bleeding and post-operative nasal surgery. It analyzes the mechanisms of action of various types of hemostatic materials, including collagen-based, cellulose-based, alginate-based, and platelet-rich plasma (PRP) materials, discussing their clinical applications, advantages, and limitations. Finally, the article explores the future direction of nasal hemostatic materials, particularly the innovative development of bioactive absorbable materials and their potential applications in nasal bleeding. Overall, with the continuous emergence of novel materials, nasal hemostatic materials are expected to play an increasingly vital role in improving therapeutic outcomes, reducing recurrence, and enhancing the quality of life for patients.</div></div>","PeriodicalId":7591,"journal":{"name":"American Journal of Otolaryngology","volume":"46 6","pages":"Article 104732"},"PeriodicalIF":1.7,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145412977","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Toasted: Is burnout affecting otolaryngology trainee career decisions? Toasted:职业倦怠会影响耳鼻喉科实习生的职业选择吗?
IF 1.7 4区 医学 Q2 OTORHINOLARYNGOLOGY Pub Date : 2025-11-01 DOI: 10.1016/j.amjoto.2025.104735
Brandon D. Abell , Victoria Fischman , Laylaa Ramos Arriaza , Cristina Cabrera-Muffly , Anne Getz , Andrew P. Johnson

Objective

Burnout is prevalent in the medical field, including within Otolaryngology – Head and Neck Surgery. To date, no study has focused on the impact burnout plays on the future career choices of otolaryngology residents and fellows. Additionally, this study aimed to assess how perceptions of burnout among subspecialty teaching faculty impacted trainees' future career choices.

Methods

An anonymous, cross-sectional survey was distributed nationally to program directors and coordinators of all ACGME-accredited Otolaryngology—Head and Neck Surgery residency programs in the United States during the 2022 academic year, with a request to forward the survey to current residents and fellows.

Results

A total of 82 trainees (72 resident physicians and 10 fellows) responded to the survey, with an estimated resident physician response rate of 4 %. 35 of the 72 residents (49 %) were planning to or were in the process of applying for a fellowship position. Burnout was cited as a factor in whether or not to pursue fellowship training for 41.3 % of respondents, and as a factor in whether or not to pursue academic medicine in 46.9 % of respondents. Witnessed or perceived burnout among faculty members also played a role in future career decisions for 61 % of respondents. Qualitative analysis revealed themes including negotiating current and future comfort/ burnout, seeking balance, and the influence of perceived burnout.

Conclusions

Personal burnout and observed burnout among faculty impacts career decision-making in a significant percentage of otolaryngology residents and fellows. Efforts to mitigate burnout are crucial to avoid determent of career choices within otolaryngology.
目的:职业倦怠在医学领域非常普遍,包括耳鼻喉头颈外科。到目前为止,还没有研究关注倦怠对耳鼻喉科住院医生和研究员未来职业选择的影响。此外,本研究旨在评估亚专业教师的职业倦怠感对学员未来职业选择的影响。方法:在2022学年期间,向美国所有acgme认证的耳鼻喉头颈外科住院医师项目的项目主任和协调员分发一项匿名横断面调查,并要求将调查转发给现有住院医师和研究员。结果:共有82名实习生(72名住院医师和10名研究员)回应了调查,估计住院医师的回复率为4%。72名住院医生中有35人(49%)正在计划或正在申请奖学金职位。41.3%的受访者将职业倦怠作为是否追求奖学金培训的一个因素,46.9%的受访者将其作为是否追求学术医学的一个因素。61%的受访者表示,教师的职业倦怠对他们未来的职业决策也有影响。定性分析揭示的主题包括协商当前和未来的舒适/倦怠,寻求平衡,以及感知倦怠的影响。结论:在耳鼻喉科住院医师和研究员中,教师的个人倦怠和观察倦怠对职业决策有显著影响。减轻倦怠的努力对于避免阻碍耳鼻喉科的职业选择至关重要。
{"title":"Toasted: Is burnout affecting otolaryngology trainee career decisions?","authors":"Brandon D. Abell ,&nbsp;Victoria Fischman ,&nbsp;Laylaa Ramos Arriaza ,&nbsp;Cristina Cabrera-Muffly ,&nbsp;Anne Getz ,&nbsp;Andrew P. Johnson","doi":"10.1016/j.amjoto.2025.104735","DOIUrl":"10.1016/j.amjoto.2025.104735","url":null,"abstract":"<div><h3>Objective</h3><div>Burnout is prevalent in the medical field, including within Otolaryngology – Head and Neck Surgery. To date, no study has focused on the impact burnout plays on the future career choices of otolaryngology residents and fellows. Additionally, this study aimed to assess how perceptions of burnout among subspecialty teaching faculty impacted trainees' future career choices.</div></div><div><h3>Methods</h3><div>An anonymous, cross-sectional survey was distributed nationally to program directors and coordinators of all ACGME-accredited Otolaryngology—Head and Neck Surgery residency programs in the United States during the 2022 academic year, with a request to forward the survey to current residents and fellows.</div></div><div><h3>Results</h3><div>A total of 82 trainees (72 resident physicians and 10 fellows) responded to the survey, with an estimated resident physician response rate of 4 %. 35 of the 72 residents (49 %) were planning to or were in the process of applying for a fellowship position. Burnout was cited as a factor in whether or not to pursue fellowship training for 41.3 % of respondents, and as a factor in whether or not to pursue academic medicine in 46.9 % of respondents. Witnessed or perceived burnout among faculty members also played a role in future career decisions for 61 % of respondents. Qualitative analysis revealed themes including negotiating current and future comfort/ burnout, seeking balance, and the influence of perceived burnout.</div></div><div><h3>Conclusions</h3><div>Personal burnout and observed burnout among faculty impacts career decision-making in a significant percentage of otolaryngology residents and fellows. Efforts to mitigate burnout are crucial to avoid determent of career choices within otolaryngology.</div></div>","PeriodicalId":7591,"journal":{"name":"American Journal of Otolaryngology","volume":"46 6","pages":"Article 104735"},"PeriodicalIF":1.7,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145407735","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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American Journal of Otolaryngology
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