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Characteristics and prognosis of intractable otomastoiditis caused by nontuberculous mycobacteria 非结核分枝杆菌所致顽固性耳乳突炎的特点及预后
IF 1.7 4区 医学 Q2 OTORHINOLARYNGOLOGY Pub Date : 2025-10-03 DOI: 10.1016/j.amjoto.2025.104728
Bang-Yan Zhang , Chen-Chi Wu , Tien-Chen Liu , Ting-Hua Yang

Objective(s)

To clarify the clinical characteristics, management, and prognosis of nontuberculous mycobacteria (NTM) otomastoiditis, a rare and intractable disease with high relapse risk. This study presents the largest case series to date, analyzing 30 patients with NTM otomastoiditis.

Methods

This retrospective case series was conducted at a single tertiary referral center. Clinical data including causative pathogens, imaging findings, antibiotic regimens, surgical interventions, complications, and audiometric outcomes were reviewed and analyzed.

Results

Among the 30 patients (14 males; mean age 55 ± 20 years), Mycobacterium abscessus was identified in 26 (87 %) cases. Skull base osteomyelitis or intracranial involvement was present in 7 (23 %) patients. All patients received anti-NTM antibiotics, with macrolides being the most frequently prescribed. The median antibiotic duration was 13 months. Twenty-three (77 %) patients underwent surgery, and 12 (40 %) had additional operations. Among 23 patients with complete audiometric data, mean air-conduction hearing thresholds improved from 64.1 to 55.6 dB HL (p = 0.04); however, irreversible total deafness developed in 3 patients.

Conclusion

Nontuberculous mycobacterial otomastoiditis requires early recognition and comprehensive management. Combined surgical debridement and prolonged antibiotic therapy are often necessary, and all patients can achieve disease control. Hearing outcomes vary, but functional preservation is possible in appropriately managed cases.
目的探讨非结核分枝杆菌(NTM)耳乳突炎这一罕见难治性疾病的临床特点、治疗及预后。这项研究提出了迄今为止最大的病例系列,分析了30例NTM耳乳突炎患者。方法本回顾性病例系列在单一三级转诊中心进行。临床资料包括致病病原体、影像学发现、抗生素治疗方案、手术干预、并发症和听力学结果进行了回顾和分析。结果30例患者中,男性14例,平均年龄55±20岁,检出脓肿分枝杆菌26例(87%)。颅底骨髓炎或颅内受累7例(23%)。所有患者均接受抗ntm抗生素治疗,大环内酯类药物是最常用的处方。抗生素的中位持续时间为13个月。23例(77%)患者接受了手术,12例(40%)患者接受了额外的手术。在23例听力数据完整的患者中,平均空气传导听力阈值从64.1提高到55.6 dB HL (p = 0.04);3例发生不可逆全聋。结论非结核性分枝杆菌性耳乳突炎需要早期识别和综合治疗。手术清创和长期抗生素治疗往往是必要的,所有患者都能达到疾病控制。听力结果各不相同,但在适当管理的情况下,功能保留是可能的。
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引用次数: 0
Editor letter 编辑的信。
IF 1.7 4区 医学 Q2 OTORHINOLARYNGOLOGY Pub Date : 2025-09-29 DOI: 10.1016/j.amjoto.2025.104724
Halime Sümeyra Sevmez
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引用次数: 0
Comment on “Assessment of TISA ‘Transcutaneous Implant Skin Anomalies’ scale for cutaneous complications related to bone conduction hearing implants” by Hernández et al. American Journal of Otolaryngology-Head and Neck Medicine and Surgery 46 (2025) 104554 Hernández等人对“骨传导听力植入物相关皮肤并发症的TISA‘经皮植入物皮肤异常’评分评估”的评论。美国耳鼻咽喉头颈医学和外科学杂志46 (2025)104554
IF 1.7 4区 医学 Q2 OTORHINOLARYNGOLOGY Pub Date : 2025-09-17 DOI: 10.1016/j.amjoto.2025.104723
C. Hajema , I.J. Kruyt , M.K.S. Hol
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引用次数: 0
Critical appraisal of “diagnosis and treatment of CSF rhinorrhea with intracranial hypertension” 《脑脊液鼻漏伴颅内高压的诊断与治疗》的批判性评价。
IF 1.7 4区 医学 Q2 OTORHINOLARYNGOLOGY Pub Date : 2025-09-13 DOI: 10.1016/j.amjoto.2025.104722
Tejaswi Gupta , Jyoti Kumar Verma , Sanjeev Yadav
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引用次数: 0
The impact of socioeconomic status on management of pediatric subglottic stenosis and outcomes. 社会经济状况对小儿声门下狭窄治疗及结果的影响。
IF 1.7 4区 医学 Q2 OTORHINOLARYNGOLOGY Pub Date : 2025-09-01 Epub Date: 2025-08-05 DOI: 10.1016/j.amjoto.2025.104718
Courtney B Shires, Roger Bui, Brooke Bocklud, Karuna Dewan

Objective: There is currently a paucity of literature detailing the socioeconomic implications on management and outcomes of pediatric subglottic stenosis. Through this study, we sought to ascertain whether disparities of social determinants of health did have a discernible impact on management of subglottic stenosis through endoscopic versus open procedures and whether there would be a difference in outcomes.

Study design: The study is a multi- institutional, academic center, retrospective case series.

Methods: The study examines pediatric patients under the age of 18 evaluated by Ochsner-affiliated hospitals through May 2012 to May 2022 with the diagnosis of subglottic stenosis, acquired or congenital, through Epic SlicerDicer search engine. Patients were stratified into low and high socioeconomic status (SES), which served as independent variables, using principal component analysis of several social determinants. We recorded sex, age, ethnicity, and completion of college education. Interventions reviewed included endoscopic treatment, open airway surgery, and presence of tracheostomy. Outcome measurements included decannulation, time to decannulation, and death. Chi squared analysis was performed on dichotomous variables and student t-test was performed for continuous variables.

Results: The groups were similar in demographics: sex, age, ethnicity, and proportion with college degree. Cotton Meyer grade was significantly higher in low SES compared to high SES (p = 0.04). Patients of low SES were significantly more likely to die (p < 0.001). Low SES patients were more likely to have an acquired rather than a congenital subglottic stenosis as compared to their high SES counterparts (p = 0.02). Low SES patients were also more likely to undergo endoscopic intervention (p = 0.03). There was no statistically significant difference in tracheostomy status or decannulation success between the two groups.

Conclusion: There were statistically significant findings between low and high SES groups. Overall, patients of low SES appeared to have greater severity of subglottic stenosis, with greater number of endoscopic interventions, and greater mortality. This study which collected data from an area with marginalized patients with poor health literacy, demonstrates that sociodemographic factors contribute to disparate intervention and outcomes in pediatric patients with subglottic stenosis.

目的:目前缺乏详细描述小儿声门下狭窄的处理和结果的社会经济影响的文献。通过这项研究,我们试图确定健康的社会决定因素的差异是否确实对通过内窥镜和开放手术治疗声门下狭窄有明显的影响,以及结果是否会有差异。研究设计:本研究为多机构、学术中心、回顾性病例系列研究。方法:本研究通过Epic SlicerDicer搜索引擎,对2012年5月至2022年5月期间在ochsner附属医院评估的18岁以下、诊断为获得性或先天性声门下狭窄的儿童患者进行调查。采用几个社会决定因素的主成分分析,将患者分为低社会经济地位(SES)和高社会经济地位(SES)作为自变量。我们记录了性别、年龄、种族和大学教育的完成程度。干预措施包括内镜治疗,开放气道手术和气管切开术。结果测量包括去管、去管时间和死亡。对二分变量进行卡方分析,对连续变量进行学生t检验。结果:这些群体在人口统计学上相似:性别、年龄、种族和大学学历比例。低社会经济地位的棉花Meyer等级显著高于高社会经济地位(p = 0.04)。结论:低SES组与高SES组之间的差异有统计学意义。总的来说,低SES患者似乎有更严重的声门下狭窄,内窥镜干预的次数更多,死亡率更高。本研究收集了来自健康素养差的边缘患者地区的数据,表明社会人口因素对声门下狭窄儿童患者的不同干预和结果有影响。
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引用次数: 0
Readability of custom chatbot vs. GPT-4 responses to otolaryngology-related patient questions. 自定义聊天机器人的可读性与GPT-4对耳鼻喉科相关患者问题的反应。
IF 1.7 4区 医学 Q2 OTORHINOLARYNGOLOGY Pub Date : 2025-09-01 Epub Date: 2025-08-06 DOI: 10.1016/j.amjoto.2025.104717
Yossef Alsabawi, Pompeyo R Quesada, David T Rouse

Background: Low health literacy among patients hinders comprehension of care instructions and worsens outcomes, yet most otolaryngology patient materials and chatbot responses to medical inquiries exceed the recommended reading level of sixth- to eighth-grade. Whether chatbots can be pre-programmed to provide accurate, plain-language responses has yet to be studied. This study aims to compare response readability of a GPT model customized for plain language with GPT-4 when answering common otolaryngology patient questions.

Methods: A custom GPT was created and provided thirty-three questions from Polat et al. (Int J Pediatr Otorhinolaryngol., 2024), and their GPT-4 answers were reused with permission. Questions were grouped by theme. Readability was calculated with Flesch-Kincaid Grade Level (FKGL) and Flesch Reading Ease (FRE) via online calculator. A board-certified, practicing otolaryngologist assessed content similarity and accuracy. The primary outcome was readability, measured by FKGL (0-18; equivalent to United States grade level) and FRE (0-100; higher scores indicate greater readability).

Results: The custom GPT reduced FKGL by an average of 4.2 grade levels (95 % confidence interval [CI]: 3.2, 5.1; p < 0.001) and increased FRE by an average of 17.3 points (95 % CI: 12.5, 21.7; p < 0.001). Improvements remained significant in three of four theme subgroups (p < 0.05). Readability was consistent across question types, and variances were equal between models. Expert review confirmed overall accuracy and content similarity.

Conclusion: Preprogramming a custom GPT to generate plain-language instructions yields outputs that meet Centers for Medicare & Medicaid Services readability targets without significantly compromising content quality. Tailored chatbots could enhance patient communication in otolaryngology clinics and other medical settings.

背景:患者的低健康素养阻碍了对护理说明的理解,并恶化了结果,然而大多数耳鼻喉科患者资料和聊天机器人对医疗咨询的回应超过了六至八年级推荐的阅读水平。聊天机器人是否可以预先编程,以提供准确、简单的语言回应,目前还有待研究。本研究旨在比较针对普通语言定制的GPT模型与GPT-4在回答常见耳鼻喉科患者问题时的反应可读性。方法:创建自定义GPT,并提供Polat等人的33个问题。(2024),他们的GPT-4答案在得到许可的情况下被重复使用。问题按主题分组。可读性采用Flesch- kincaid Grade Level (FKGL)和Flesch Reading Ease (FRE)通过在线计算器计算。一位经过认证的执业耳鼻喉科医生评估了内容的相似性和准确性。主要指标为可读性,由FKGL (0-18;相当于美国年级水平)和FRE (0-100;分数越高说明可读性越好)。结果:自定义GPT平均降低了4.2个等级水平的FKGL(95%置信区间[CI]: 3.2, 5.1;p结论:预编程自定义GPT以生成简单的语言指令,产生满足医疗保险和医疗补助服务中心可读性目标的输出,而不会显著影响内容质量。量身定制的聊天机器人可以加强耳鼻喉科诊所和其他医疗机构的患者交流。
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引用次数: 0
Commentary 评论
IF 1.7 4区 医学 Q2 OTORHINOLARYNGOLOGY Pub Date : 2025-08-07 DOI: 10.1016/j.amjoto.2025.104720
Cheng Zhong
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引用次数: 0
The data presented in Zhi et al. do not support the conclusion that HBOT leads to worse hearing improvement in sudden hearing loss Zhi等人提供的数据不支持HBOT导致突发性听力损失患者听力改善更差的结论
IF 1.7 4区 医学 Q2 OTORHINOLARYNGOLOGY Pub Date : 2025-08-05 DOI: 10.1016/j.amjoto.2025.104719
Kiran Ganga , Christopher Niemczak , Jay Buckey
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引用次数: 0
A comparison of quality and readability of Artificial Intelligence chatbots in triage for head and neck cancer 人工智能聊天机器人在头颈癌分诊中的质量和可读性比较
IF 1.7 4区 医学 Q2 OTORHINOLARYNGOLOGY Pub Date : 2025-07-29 DOI: 10.1016/j.amjoto.2025.104710
Taylor Kring , Soumil Prasad , Supriya Dadi , Eric Sokhn , Elizabeth Franzmann

Objective

Head and neck cancers (HNCs) are a significant global health concern, contributing to substantial morbidity and mortality. AI-powered chatbots such as ChatGPT, Google Gemini, Microsoft Copilot, and Open Evidence are increasingly used by patients seeking health information. While these tools provide immediate access to medical content, concerns remain regarding their reliability, readability, and potential impact on patient outcomes.

Methods

Responses to 25 patient-like HNC symptom queries were assessed using four leading AI platforms: ChatGPT, Google Gemini, Microsoft Copilot, and Open Evidence. Responses were evaluated using modified DISCERN criteria for quality and SMOG scoring for readability, with ANOVA and post hoc analysis conducted afterward.

Results

Microsoft Copilot achieved the highest mean DISCERN score of 41.40 (95 % CI: 40.31 to 42.49) and the lowest mean SMOG reading levels of 12.56 (95 % CI: 11.82 to 13.31), outperforming ChatGPT, Google Gemini, and Open Evidence in overall quality and accessibility (p < .001). Open Evidence scored lowest in both quality averaging 30.52 (95 % CI: 27.52 to 33.52) and readability of 17.49 (95 % CI: 16.66 to 18.31), reflecting a graduate reading level.

Conclusion

Significant variability exists in the readability and quality of AI-generated responses to HNC-related queries, highlighting the need for platform-specific validation and oversight to ensure accurate, patient-centered communication.

Level of evidence

Our study is a cross-sectional analysis that evaluates chatbot responses using established grading tools. This aligns best with level 4 evidence.
目的头颈癌(HNCs)是一个重要的全球健康问题,导致大量发病率和死亡率。ChatGPT、谷歌Gemini、Microsoft Copilot和Open Evidence等人工智能聊天机器人越来越多地被患者用于寻求健康信息。虽然这些工具提供了对医疗内容的即时访问,但人们仍然担心它们的可靠性、可读性和对患者结果的潜在影响。方法采用ChatGPT、b谷歌Gemini、Microsoft Copilot和Open Evidence四种领先的人工智能平台,对25个类似患者的HNC症状查询进行评估。使用修改后的DISCERN质量标准和烟雾可读性评分对反馈进行评估,随后进行方差分析和事后分析。结果microsoft Copilot的平均识别率最高为41.40分(95% CI: 40.31 ~ 42.49),平均识别率最低为12.56分(95% CI: 11.82 ~ 13.31),在整体质量和可及性方面优于ChatGPT、谷歌Gemini和Open Evidence (p <;措施)。Open Evidence在质量(平均30.52 (95% CI: 27.52至33.52)和可读性(17.49 (95% CI: 16.66至18.31))方面得分最低,反映了研究生的阅读水平。结论:人工智能生成的hnc相关查询的回复的可读性和质量存在显著差异,强调需要针对特定平台进行验证和监督,以确保准确、以患者为中心的沟通。证据水平我们的研究是一个横断面分析,使用既定的评分工具来评估聊天机器人的反应。这与4级证据最吻合。
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引用次数: 0
Management of acute invasive fungal rhinosinusitis in immunocompromised children: a narrative review 免疫功能低下儿童急性侵袭性真菌性鼻窦炎的治疗:一篇叙述性综述
IF 1.7 4区 医学 Q2 OTORHINOLARYNGOLOGY Pub Date : 2025-07-28 DOI: 10.1016/j.amjoto.2025.104698
Francesca Galluzzi , Werner Garavello

Objective

The aim is to review the current evidence for the management of acute invasive fungal rhinosinusitis (AIFR) in immunocompromised children.

Material and methods

A systematic search of PubMed, Embase, and Cochrane Library was performed. Data regarding the epidemiology, clinical presentation, diagnostic instruments, and treatments of pediatric AIFR were narratively summarized and critically analyzed.

Results

The management of AIFR in immunocompromised children can be very challenging because of the paucity of symptoms and rapidly progressive disease. The following key concepts are crucial to optimize the management: 1) early diagnosis through clinical features (sinonasal, oral, ocular, neurological symptoms and fever) and instrumental exams (nasal endoscopy with biopsy, microbiological tests, CT and MRI); 2) vigorous medical antifungal therapy associated with surgical treatment (endoscopic/open); 3) treat the underlying immunosuppression by improving immunocompetence; 4) close follow-up and prompt intervention in case of recurrence.

Conclusion

AIFR in immunocompromised children is a rare but serious condition that requires the use of fast and precise methods that can support clinicians in its management. In this perspective, a multidisciplinary diagnostic and therapeutic approach is essential. However, mortality is still high and further research is needed to improve knowledge in this field.
目的回顾免疫功能低下儿童急性侵袭性真菌性鼻窦炎(AIFR)治疗的现有证据。材料与方法系统检索PubMed、Embase和Cochrane Library。对儿童AIFR的流行病学、临床表现、诊断工具和治疗方法进行了叙述总结和批判性分析。结果免疫功能低下儿童的AIFR治疗非常具有挑战性,因为症状少且疾病进展迅速。以下关键概念对优化管理至关重要:1)通过临床特征(鼻窦、口腔、眼部、神经系统症状和发烧)和仪器检查(鼻内镜活检、微生物检查、CT和MRI)进行早期诊断;2)与手术治疗(内窥镜/开放)相关的有力药物抗真菌治疗;3)通过提高免疫能力来治疗潜在的免疫抑制;4)密切随访,发现复发及时干预。结论免疫功能低下儿童的aifr是一种罕见但严重的疾病,需要使用快速精确的方法来支持临床医生对其进行管理。从这个角度来看,多学科的诊断和治疗方法是必不可少的。然而,死亡率仍然很高,需要进一步研究以提高这一领域的知识。
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引用次数: 0
期刊
American Journal of Otolaryngology
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