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[Morphological and functional analysis of dento-orofacial complex in monozygotic twins with Duchenne type muscular dystrophy]. [杜氏型肌营养不良同卵双胞胎牙颌面复合体的形态学和功能分析]。
M Watanabe, K Shimizu, S Nakata, K Watanabe, T Morishita, S Miyoshino

The form of dento-orofacial complex and masticatory muscle function of monozygotic twins with Duchenne type muscular dystrophy were investigated. They had no environmental difference. Morphological analysis were performed on the dental casts and cephalograms. EMG recordings were derived from the bipolar surface electrodes on the masseter muscle and the anterior belly of digastric muscle on the left side. Each consisted of the data for three years. Results obtained are as follows: 1) Based on the average data, these patients showed an elongated dental arch in the maxilla and mandible, which might be caused by enlarged tongues. There were little difference in the tooth and dental arch sizes between them. 2) Cephalometric findings indicated that the elder brother showed a clockwise rotation of the mandible with larger gonial angle than the younger brother. Both of them showed a larger gonial angle based on the mean values. 3) Analysis of EMG recordings revealed an elongated silent period induced by teeth tapping and chin tapping, and a variable masticatory rhythm compared with that of normal sample. Moreover an annually increased imbalance between masseter muscle and digastric muscle was evident, which were parallel to the change of the blood creatine kinase value. Differences in the form and function of orofacial complex between them might be caused by their polygene heredity and the large size of DMD gene (XP 21).

对杜氏型肌营养不良同卵双胞胎的牙颌面复合体形态和咀嚼肌功能进行了研究。他们没有环境差异。对牙模及头颅造影进行形态学分析。肌电图记录来自于咬肌和左侧二腹肌前腹的双极表面电极。每一个都包含了三年的数据。结果如下:1)从平均数据来看,这些患者上颌和下颌骨的牙弓拉长,这可能是由于舌变大引起的。他们的牙齿和牙弓大小几乎没有差别。2)头颅测量结果显示,哥哥的下颌骨呈顺时针方向旋转,下颌骨角大于弟弟。两者在平均值基础上都显示出较大的角。3)肌电图分析显示,与正常对照组相比,轻叩牙齿和轻叩下巴引起的沉默期延长,咀嚼节奏变化。此外,咬肌和二腹肌之间的不平衡明显逐年增加,这与血肌酸激酶值的变化平行。它们之间口面复合体的形态和功能的差异可能是由它们的多基因遗传和DMD基因的大尺寸(XP 21)引起的。
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引用次数: 0
[Effects of the localized thermal enhancement on new bone formation following mechanical expansion of the rat sagittal suture]. [局部热增强对大鼠矢状缝机械扩张后新骨形成的影响]。
H Ogawa

The purpose of this study was to investigate the effects of localized thermal enhancement on new bone formation in rats. Sixty four male Wistar rats of 52-day old were used as the experimental animal. The sagittal suture of the rat was expanded with the force of 75 g by means of an expansion appliance. After the force application for 2 days, the expansion appliance was fixed with a composite resin. The infrared ray was applied to the expanded sagittal suture for 20 minutes a day and the temperature, just above the sagittal suture, was measured with a biothermometer. The local heat was given for 5-days. The experimental animals were divided into 4 groups based on the increase of temperature: Control, 1 degree C, 2.5 degrees C and 4 degrees C groups. The sagittal suture of each rat was examined by both light and fluorescent microscopies. And histochemistry for acid phosphatase and tartrate-resistant acid phosphatase (TRAP) were performed. The results obtained were as follows: 1) In control and 1 degree C groups, little reaction of acid phosphatase and TRAP were observed in the sutural tissue except for the marrow and the neighboring area of the capillary vessels. 2) In 2.5 degrees C and 4 degrees C groups, an increased absorptive area of the bone and an active reaction of acid phosphatase were found in the sutural area. 3) In only 1 degree C group, an increased new bone formation was evident in the sutural area. Results obtained suggested that the degree of new bone formation depended on the temperature of tissues concerned.

本研究旨在探讨局部热增强对大鼠新生骨形成的影响。以52日龄雄性Wistar大鼠64只为实验动物。用扩张器对大鼠矢状缝合线施加75g的力进行扩张。施力2天后,用复合树脂固定膨胀器。红外线照射扩大的矢状缝合线,每天20分钟,用体温计测量矢状缝合线上方的温度。局部加热5 d。实验动物按温度升高程度分为4组:对照组、1℃组、2.5℃组和4℃组。用光镜和荧光显微镜观察各大鼠矢状面缝合线。对酸性磷酸酶和抗酒石酸酸性磷酸酶(TRAP)进行组织化学检测。结果表明:1)在对照组和1℃组,除骨髓和毛细血管邻近区域外,其他缝合组织中均未见酸性磷酸酶和TRAP的反应。2)在2.5℃和4℃组,骨的吸收面积增大,缝合处酸性磷酸酶反应活跃。3)仅在1℃组,缝合区新骨形成明显增加。结果表明,新骨的形成程度与相关组织的温度有关。
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引用次数: 0
[A long-term study on dentofacial changes after sagittal splitting osteotomies in skeletal Class III malocclusions]. [骨性III类错颌矢状劈开截骨术后牙面变化的长期研究]。
H Mizuno, S Morita, H Sasakura, K Hanada

The purpose of this study is to clarify the long-term dentofacial changes after sagittal splitting ramus osteotomy in skeletal Class III patients, and to study the factors involved to find its countermeasures. For this purpose we used the radiographic cephalograms in 16 patients (13 females and 3 males) observed for more than five years after surgery. We measured the postoperative changes in the position of Pogonion and the inclination of maxillary and mandibular incisors. The results were as follows: 1. Pogonion was retruded 9.3 mm on the average by surgery. In the period from the removal of intermaxillary fixation to one year postoperatively Pogonion slipped forwardly and upwardly (average; anteriorly 1.0 mm, superiorly 0.8 mm). In the period from one year postoperatively to the time of the final observation Pogonion slipped to a downward direction. 2. No correlation was found between the amounts of vertical displacement by surgery and postoperative vertical changes of Pogonion. On the other hand, a high correlation was found between the amounts of mandibular setback and the forward displacement of Pogonion. 3. Mandibular incisors were tipped labially by preoperative orthodontic treatments, then maxillary and mandibular incisors moved lingually during intermaxillary fixation. After release of intermaxillary fixation, maxillary incisors moved labially in a small distance. After one year maxillary incisors were inclined slightly in the lingual direction. It is obvious that the position of the mandible and the incisor inclination tend to change even after one year. Because the postoperative changes were small in quantity, we supposed they were mostly caused by occlusal changes. Clinically, occlusal relationship in the incisor area, i.e., overjet and overbite, was maintained to be normal. It was considered that the changes of incisal inclination after release of intermaxillary fixation were of a compensatory or adaptational response to a positional change of the mandible.

本研究的目的是明确骨ⅲ类患者矢状分叉支截骨术后长期牙面变化,并研究其影响因素,寻求对策。为此,我们使用了16例患者(13名女性,3名男性)术后5年以上的头颅x线摄影。我们测量了术后Pogonion位置和上颌、下颌切牙倾斜度的变化。实验结果如下:1.实验结果表明:术后脓肿平均后移9.3 mm。从拔除上颌间固定到术后一年,Pogonion向前和向上滑动(平均;正面1.0 mm,正面0.8 mm)。术后1年至最后一次观察,Pogonion呈下降趋势。2. 术中垂直位移量与术后Pogonion垂直变化无相关性。另一方面,下颌骨后退量与下颌骨前移有高度相关。术前进行正畸治疗时,下颌切牙唇端倾斜,上、下颌切牙在上颌间固定时舌端移动。上颌间固定解除后,上颌切牙向唇侧移动一小段距离。1年后,上颌门牙向舌方向轻微倾斜。很明显,下颌骨的位置和门牙的倾斜度即使在一年后也有变化的趋势。由于术后变化量小,我们认为主要是咬合变化引起的。临床维持切牙区牙合关系正常,即上牙合与上牙合。我们认为上颌间固定解除后的切侧倾斜度变化是对下颌骨位置变化的代偿性或适应性反应。
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引用次数: 0
[The present states and considerations of orthognathic surgery in Japan. Questionnaire in department of orthodontics of university dental hospital, and department of oral surgery of university medical hospital]. 日本正颌外科的现状与思考。大学口腔医院正畸科、大学附属医院口腔外科问卷调查[j]。
T Nihei, K Itoh, M Kobayashi, T Hoshi, Y Shinbo, K Hanada

To investigate the present state of orthognathic surgery, questionnaires were sent to 30 departments of orthodontics of university dental hospital and 60 departments of oral surgery of university medical hospital. 1. Orthognathic surgery was carried out in 100% of the departments of orthodontics and 91.8% of the departments of oral surgery examined. 2. There was a difference in the number of patients between individual hospitals. 3. Analyses of cephalogram were used in 96% of the departments of orthodontics and 93% of the departments of oral surgery. 4. Pre- and post-surgical orthodontic treatments were carried out in all of the departments of orthodontics. 5. Orthodontic appliances (83.9%) were used in the departments of orthodontics for intermaxillary fixation, while orthodontic appliances (47.8%) and wire splints (49.2%) were used in the departments of oral surgery. 6. It is pointed out that the criterion of orthognathic surgery, treatment objectives on soft and hard tissue, selection of surgical method, adaptability of soft tissue after surgery, relapse, treatment planning of two jaw surgery, and postoperative stability remain to be solved in future.

采用问卷调查的方法,对大学口腔医院正畸科30个,大学附属医院口腔外科60个科室进行调查。1. 正畸科和口腔外科的正畸手术检出率分别为100%和91.8%。2. 各个医院的病人数量有所不同。3.96%的正畸科和93%的口腔外科采用了脑电图分析。4. 术前和术后的正畸治疗在所有正畸科进行。5. 正畸科使用正畸矫治器(83.9%)固定上颌间,口腔外科使用正畸矫治器(47.8%)和金属丝夹板(49.2%)固定。6. 指出正颌手术的标准、软硬组织的治疗目标、手术方式的选择、术后软组织的适应性、复发、双颌手术的治疗方案、术后稳定性等仍是今后有待解决的问题。
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引用次数: 0
[Correlation between morphologies of mandibular vertical sections and linear measurements of the skull]. [下颌垂直剖面形态学与颅骨线性测量的相关性]。
K Kasai, Y Nakajima, M Mashita, K Yasuda, Y Enomoto, K Go, T Iwasawa, E Kanazawa

The purpose of this study is to evaluate the relationships between the sectional forms of the mandible and the craniofacial morphology. Vertical sections were made at the symphysis (SY) and at the second molar region (M2R). Materials were dried human skulls which were measured in three dimensional co-ordinate system. The correlation matrix of 24 measurements was examined in the male and the female. The difference of these measurements between the low angle group and the high angle group of gonial angle was also examined. Results obtained were as follows: 1. Gonial angle was negatively correlated with the height, width, breadth of ramus and the breadth of second molars. SY form was related to the facial height and size of the mandible. On the other hand, M2R form was related to the height, width and breadth of ramus. 2. The differences of measurements between the low angle group and the high angle group of gonial angle were as follows: 1) The ramal height, ramal width, bicondylar width and breadth of second molars in the low angle group were significantly larger than those in the high angle group. 2) The measurements of SY in the high angle group and the low angle group showed no significant difference. 3) The height and area of M2R in the low angle group were significantly larger than those in the high angle group. This study demonstrated that SY form might relate to vertical factors of the face (facial height), the size of mandible and the types of occlusions. On the other hand, M2R form being nearer to the attachment of masseter and medial pterygoid muscles than SY was related to the form of ramus and the gonial angle.

本研究的目的是评估下颌骨的断层形态与颅面形态之间的关系。在联合处(SY)和第二磨牙区(M2R)做垂直切片。材料为干燥的人头骨,在三维坐标系下测量。对男性和女性进行了24项测量的相关矩阵检测。并对低角组和高角组的测量结果进行了比较。实验结果如下:1。角与支高、支宽、支宽、第二磨牙宽度呈负相关。SY形态与面部高度和下颌骨大小有关。另一方面,M2R形态与分支的高度、宽度和宽度有关。2. 低角组与高角组的牙槽角测量差异如下:1)低角组第二磨牙牙槽高度、牙槽宽度、双髁宽度、第二磨牙牙槽宽度均显著大于高角组。2)高角度组和低角度组的SY测量值无显著差异。3)低角度组M2R高度和面积均显著大于高角度组。本研究表明,SY形态可能与面部垂直因素(面部高度)、下颌骨大小和咬合类型有关。另一方面,M2R形态较SY更接近咬肌和翼状内侧肌的附着,与支的形态和角有关。
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引用次数: 0
[Tooth formation and eruption in skeletal Class II and Class III malocclusions]. [骨骼ⅱ类和ⅲ类错咬合的牙齿形成和出牙]。
M Sasaki, K Sato, H Mitani

The purpose of this study was to investigate the timing of the formation and eruption of the permanent teeth between Skeletal Class II and Class III malocclusions right before pubertal growth period. Samples consisted of twenty five Japanese girls of Class II and Class III malocclusions, respectively, with Class I girls as a control. Materials used in this study were panoramic X-rays, dental X-rays and intraoral photographs of each sample, all taken at age of 8 years. Lateral cephalometric X-rays, wrist bone X-rays and records of standing height were used to study the craniofacial characteristics and the stage of bone maturation. Results were as follows: 1. Lower teeth formation of Class III group tended to be advanced when compared with Class II group, especially at molars. 2. There was no significant difference between the two groups with regard to the timing of eruption except lower lateral incisors, but eruption of the upper second molar of Class III group tended to be delayed. Results suggested that the skeletal disharmony may be associated with different timing of formation and eruption of the permanent teeth.

本研究的目的是探讨在青春期生长之前,骨骼II类和III类错合之间的恒牙形成和出牙的时间。样本由25名ⅱ类和ⅲ类错颌女孩组成,ⅰ类女孩作为对照。本研究使用的材料是每个样本的全景x光片、牙科x光片和口内照片,均拍摄于8岁时。采用侧位头颅x线、腕骨x线和站立高度记录研究颅面特征和骨成熟阶段。结果如下:1。与第二类人相比,第三类人的下牙形成有提前的趋势,尤其是磨牙。2. 除下侧切牙外,两组间无显著性差异,但ⅲ类组上第二磨牙的出牙时间有延迟的趋势。结果表明,恒牙的形成和出牙的时间不同可能与骨骼不和谐有关。
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引用次数: 0
[Recognition of orthodontic patients and their parents about the orthodontic treatment and results--a questionnaire method]. 【正畸患者及其家长对正畸治疗及结果的认知——问卷调查法】。
M Kouguchi, K Itoh, K Yamabe, N Morimoto, H Yabuno, Y Iwami, N Kimura, K Miyamoto, K Yamauchi

This study was undertaken to investigate the desire and consciousness of orthodontic patients and their parents on the content and effect of orthodontic treatment. The subjects were 362 post-treatment patients and 353 of their parents, who answered the questionnaires. The following conclusions were obtained: 1. 49% of the patients and 16% of the parents of the patients thought of giving up the treatment while the patients were under the orthodontic treatment. The main reasons were the discomfort of orthodontic appliances, long treatment period, and the absence from school. 2. 55% of the patients felt uneasy about a change of the occlusion for the worse after removal of the orthodontic appliances, and 60-70% of the patients and parents had forgotten the necessity of the retainer after active orthodontic treatment. 3. Both patients and parents hoped to finish the orthodontic treatment by the end of junior high school. 4. About 50% of the parents preferred the university hospital and about 45% preferred a private dental office which was convenient for attending as an outpatient. 5. About 70% of the patients and parents were satisfied with occlusion after orthodontic treatment, and 33% of the patients and 61% of the parents were satisfied with the orofacial appearance after treatment. 6. About 9% of the patients hoped to keep secret their history of orthodontic treatment. 7. About 35% of the patients and 60% of the parents would recommend people with malocclusions to receive orthodontic treatment. About 80% of the patients would make their own children receive the orthodontic treatment if needed. 8. About 90-95% of the patients and parents were pleased with orthodontic treatment.

本研究旨在了解正畸患者及其家长对正畸治疗内容及效果的意愿和意识。研究对象为362名治疗后患者及其353名父母,他们回答了问卷。得到以下结论:1。患者在正畸治疗期间有49%的患者和16%的患者家长有放弃治疗的想法。主要原因是矫治器不适、治疗时间长、缺课。2. 55%的患者在拔除矫治器后对咬合的变化感到不安,60-70%的患者和家长在积极矫治后忘记了固位器的必要性。3.患者和家长都希望在初中结束前完成正畸治疗。4. 约50%的家长更喜欢大学医院,约45%的家长更喜欢私人牙科诊所,因为作为门诊病人就诊方便。5. 约70%的患者及家长对正畸治疗后的咬合满意,33%的患者及61%的家长对治疗后的口面外观满意。6. 约9%的患者希望对其正畸治疗史保密。7. 约35%的患者和60%的家长会推荐错颌患者接受正畸治疗。如果有需要,约80%的患者会让自己的孩子接受正畸治疗。8. 约90-95%的患者及家长对正畸治疗满意。
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引用次数: 0
[An immunohistochemical study on the response of nerve fibers in the periodontium of rat molars during experimental tooth movement]. 大鼠实验性牙齿移动过程中磨牙牙周膜神经纤维反应的免疫组织化学研究
I Saitoh, K Ishii, M Kobayashi, K Hanada, T Maeda, O Sato

It is well known that orthodontic forces induce pain during tooth movement. However there have been few neurohistological studies on sensational periodontal tissue response to orthodontic tooth movement. So we have many unknown problems about reactions of periodontal nerve fibers during tooth movement. The present study deals with the response of nerve fibers in periodontal ligament of rat molar during experimental tooth movement by means of immunohistochemical method for calcitonin gene-related peptide (CGRP). The results obtained in this study were as follows: 1. In control sections, CGRP-immunopositive nerve fibers were observed both around the root apex and in the intermediate region of the periodontal ligament. Although most of those fibers was distributed around the blood vessels, a few nerves were recognized to terminate in the periodontal fibers. 2. At three days after tooth movement, the CGRP-positive nerves gradually increased in number around the blood vessels. After that, the number of CGRP-positive nerves decreased and no difference of distribution of CGRP-positive nerves was observed between the control sections and the experimental sections at seven days. 3. Especially, at three days when active remodeling of alveolar bone was taking place, a few nerve fibers showing CGRP-immunoreactivity were observed to concentrate around osteoclasts or to migrate Howship's lacunae. These findings showed the dynamic changes of CGRP-immunoreactive nerves in the periodontal ligament during tooth movement, and suggested that this reaction of the periodontal nerves might induce pain in patients. In addition to neurotransmitter function, it was supposed that CGRP directly or indirectly effected the cellular elements and surrounding tissues on peripheral organs such as vascular system and osteoclasts.

众所周知,在牙齿移动时,正畸力会引起疼痛。然而,关于正畸牙齿移动引起的牙周组织反应的神经组织学研究很少。因此,关于牙周神经纤维在牙齿运动过程中的反应仍有许多未知的问题。本研究采用降钙素基因相关肽(CGRP)免疫组化方法研究大鼠磨牙牙周韧带神经纤维在实验性牙齿移动过程中的反应。本研究得到的结果如下:1。在对照切片中,根尖周围和牙周韧带中间区域均可见cgrp免疫阳性神经纤维。虽然这些纤维大多分布在血管周围,但也有少数神经在牙周纤维中终止。2. 在牙齿移动后3 d,血管周围的cgrp阳性神经逐渐增多。之后,cgrp阳性神经数量减少,7 d时,对照组与实验组间cgrp阳性神经分布无差异。3.特别是在肺泡骨发生活性重构的第3天,观察到少量具有cgrp免疫反应性的神经纤维集中在破骨细胞周围或向Howship氏腔隙迁移。这些结果显示牙周韧带中cgrp免疫反应神经在牙齿运动过程中的动态变化,提示牙周神经的这种反应可能引起患者疼痛。CGRP除具有神经递质功能外,还可能直接或间接影响血管系统、破骨细胞等外周器官的细胞元件和周围组织。
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引用次数: 0
Effects of complete separation of condyle on the facial growth of growing rats. 髁突完全分离对生长大鼠面部生长的影响。
K Miyajima, K Yoshida, Y Morikawa, Y Ikemori, K Shirakawa, T Iizuka

Normal mastication needs condylar support. Mandibular condyle is thought to be one of the factors which control facial growth. To determine which parts of the face are affected by unilateral complete condylotomy including surrounding connected soft tissues, thirty-nine male Wistar rats, 5 weeks of age, were divided into control, sham treated and experimental groups. The control animals received no treatment, where as the left mandibular condyles of the experimental animals were condylotomized. Soft X-rays of the animals of both groups were taken every two weeks, and all were killed six weeks after treatment. Roentgenografically, it was observed in the experimental animals that a functional condyle-like process generated to fill the condylar space of glenoid fossa. This process was smaller than normal condyle of the control anomals. Furthermore, ANOVA revealed significant differences (P less than 0.01) in some facial structures including facial height as well as mandibular length, which were still affected at six weeks after the surgery. The result of the present investigation suggests that unilateral condylotomy induced the production of a functional condyle-like process and caused some facial deformities.

正常咀嚼需要髁突支撑。下颌髁被认为是控制面部生长的因素之一。为了确定单侧完全性髁突切断术对面部包括周围连接软组织的影响,将5周龄雄性Wistar大鼠39只分为对照组、假手术组和实验组。对照组动物不接受任何治疗,而实验动物的左下颌髁被切除。每两周对两组动物进行软x光检查,治疗六周后全部死亡。x线摄影在实验动物中观察到一个功能性的髁状突起,填充了盂窝的髁间隙。这一过程小于正常髁的控制异常。此外,方差分析显示,面部高度和下颌长度等部分面部结构在术后6周仍受影响,差异有统计学意义(P < 0.01)。本研究结果表明,单侧髁状突切开术诱导了功能髁状突的产生,并引起了一些面部畸形。
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引用次数: 0
[Psychological study of questionnaire relating to dentition and orthodontic treatment]. [牙列与正畸治疗相关问卷的心理研究]。
M Syono, W Tada, Y Rokusya, Y Zuiki, S Tensin, T Tabuchi, K Yamaguchi, T Suzuki, T Kawata

Concern of patients for dentition and receptivity of orthodontic treatment was studied by a general population questionnaire. Subjects (general population) consisted of elder elementary school boys and girls (157), junior high school (274) and high school students (90) and adults (45) in Tokushima, Kagawa and Kouchi prefectures. Twenty-three questions, previously selected from forty-seven using the Quantification III for orthodontic patients. Furthermore, ten questions were selected from these twenty-three using the same method and categorized into two groups. Each category was given a meaning. Five answers in each category were given marks: a positive answer was 'point one' and a negative one was 'point zero'. Mean points in each category were compared with eight groups according to age and sex. AIC (Akaike Information Criterion) was used for statistical analysis. The following results were obtained. 1. Two categories were independently identified. One had meaning in relation to concern for dentition and other had meaning in relation to receptivity of orthodontic treatment. 2. Orthodontic patients showed significantly higher points than general population for concern and receptivity. 3. Females in each group showed higher points for concern of dentition in general population, but males showed higher points for receptivity of orthodontic treatment. 4. Junior high school and high school students showed significantly lower points in two categories, in addition, males in this group showed lower points in these categories. 5. There were no significant differences between subjects in three prefectures. It is possible for general population to evaluate instructions or education methods for promoting interest in dentition by this study. Orthodontic patients will also be encouraged by the present study to receive orthodontic treatment.

通过普通人群问卷调查,研究了患者对牙列的关注程度和对正畸治疗的接受程度。研究对象(一般人群)包括德岛县、香川县和Kouchi县的小学高年级男生和女生(157人)、初中生(274人)和高中生(90人)以及成年人(45人)。23个问题,先前从47个正畸患者使用量化III选择。此外,用同样的方法从这23个问题中选出10个问题,并分为两组。每个类别都有一个含义。每个类别的五个答案都有分数:肯定的答案是“1分”,否定的答案是“0分”。根据年龄和性别,将每个类别的平均值与八组进行比较。采用赤池信息标准AIC (Akaike Information Criterion)进行统计分析。得到了以下结果:1. 两个类别被独立确定。一个是关于对牙齿的关注另一个是关于对正畸治疗的接受度。2. 正畸患者的关注度和接受度均明显高于普通人群。3.各组女性对一般人群牙列的关注程度较高,而男性对正畸治疗的接受程度较高。4. 初中生和高中生在这两项得分均显著较低,且本组男性在这两项得分均较低。5. 三县受试者间无显著差异。通过本研究,普通人群有可能对促进牙科学兴趣的指导或教育方法进行评估。本研究也将鼓励正畸患者接受正畸治疗。
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引用次数: 0
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Nihon Kyosei Shika Gakkai zasshi = The journal of Japan Orthodontic Society
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